3K45A

Alternate binding modes observed for the e- and z-isomers of 2,4-diaminofuro[2,3d]pyrimidines as ternary complexes with nadph and mouse dihydrofolate reductase
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
186
structure length
186
Chain Sequence
VRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPDLASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Mus musculus
molecule keywords Dihydrofolate reductase
total genus 55
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2009-10-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3k45A00
3FYWX 4KAKA 4DPHA 1DR4A 4OR7A 3JWMA 3FL9A 1PD9A 4X5GA 2W9TA 4HOFA 3S7AA 1RX9A 1DIUA 1DREA 1PDBA 3SQYX 3DRCA 1DISA 2ANOA 3QYLA 1JUVA 1CD2A 4HOEA 4G3MA 1DG7A 2O7PA 3GI2A 2W9GA 2HXVA 3FL8A 3FREX 1OHKA 2OIPA 4PSTA 1AO8A 5DXVA 1DYRA 3VCOA 1RG7A 1RX4A 4LAEX 1JOLA 4PDJA 3FY8X 4M7UA 3SRUX 2G6VA 1RX3A 3NXVA 4DP3A 4KY8A 3EEMA 2AZNA 3S9UA 3JW3A 3K45A 1HFPA 3EIGA 3N0HA 3M09A 1DRHA 3JW5A 5HF2X 4M2XA 3NXRA 4KEBA 5HF0X 3F8YA 1BOZA 2QK8A 2DHFA 2INQA 5HQYA 1VJ3A 3I3RA 4KLXA 4CD2A 4ELEA 3FQOA 3FQVA 5HVEA 3K47A 3QLYA 1S3UA 4FHBA 4H96A 1TDRA 4M6KA 1DYJA 3K2HA 3SA2A 2HM9A 3IX9A 3F0UX 5HT4A 3ZPGA 2XW7A 5ECCA 1DR5A 3QFXA 1D1GA 4M6JA 4KM2A 1HFQA 4P66A 7DFRA 1LY4A 1RH3A 3F8ZA 1SEJA 3SRSX 3NXOA 2W3VA 3NZAX 3QG2A 3SGYA 1DR2A 3NZBX 2KGKA 4G95A 5CCCA 2HQPA 1DRAA 3S3VA 1DRBA 4NX6A 3F0VX 4PTJA 2W9HA 1BZFA 4RGCA 1DHJA 1LY3A 1CZ3A 4OSGA 1E26A 4ECKA 3FRBX 3IROA 1RC4A 3GHCA 3JSUA 3SR5X 3RO9A 3IRMA 4H97A 4IXFX 4KM0A 5HI6A 4Q0DA 1RA1A 2D0KA 3UM6A 8DFRA 2L28A 3TQ8A 3NZ9X 4KD7A 1DR3A 4M7VA 3FYVX 3JWFA 3FRDX 3IA4A 3TQ9A 1KMVA 2DRCA 2GD9A 1RX2A 4KJKA 1YHOA 2ZZAA 1RX1A 5JA3A 3EEKA 4ELHA 1DR7A 3NZ6X 4QHVA 3SRWX 1MVTA 5E8QA 4NX7A 4XRBA 1IA4A 1JOMA 3QLZA 4QI9A 2CD2A 4FGGA 4I1NA 3QLXA 2LF1A 5HPBA 2D5NA 1S3WA 3DG8A 2P4GA 5ECXA 3RG9A 3SH2A 1OHJA 4PSYA 1RE7A 3OAFA 4QLFA 3K74A 4XT6A 4QLEA 3NZCX 4HA7A 1DAJA 1DYIA 4M6LA 1M78A 1KMSA 3HBBA 3TD8A 4ELBA 3KJSA 1RA2A 4Q0EA 3FQCA 4XE6X 4KL9A 3TQAA 3FS6A 1RD7A 4QLGA 1DHIA 3GHWA 3DATA 4XT7A 3QLRA 4KYAA 4ELGA 3DGAA 1DYHA 3D84X 5HQZA 1U72A 3UM8A 4G8ZX 3GYFA 4GH8A 6DFRA 3QLWA 3ZPCA 3I8AX 1IA3A 4XT4A 4DPDA 1HFRA 3F91A 3FRFX 3QLSA 3KY8A 1J3IA 5CC9A 2OBCA 2ITHA 1DG5A 3NU0A 1MVSA 1RA9A 2FZIA 4H95A 4KBNA 1RX5A 3UM5A 2BLBA 1IA1A 1RA8A 3JTWA 1RB3A 4ELFA 3QGTA 4XT8A 4PSSA 3DL6A 1RX8A 3Q1HA 5U26A 4XECX 4X5IA 3SRRX 4P3QA 2FZHA 3NXTA 1RA3A 4EILA 3SAIA 4QJCA 1DR1A 2C2SA 4TU5X 3DFRA 3EX8A 4LAHX 3NTZA 3KJRA 2W3MA 3INVA 4DFRA 3KFYA 2BL9A 3M08A 2ANQA 5HUIA 1LUDA 1DF7A 1DLRA 4KFJA 4X5FA 4IXED 1S3VA 4Q67A 3HJ3A 3TQBA 3NZDA 2W3BA 1DHFA 2B3ZA 2W3AA 2H2QA 3FQFA 5HVBA 1J3JA 1DDSA 3EEJA 4FGHA 3CLBA 4Q6AA 1DRFA 3NXXA 3FQ0A 3QL3A 4LAGX 4DDRA 3F0SX 3QYOA 4X5HA 3R33A 5FDAA 1DR6A 3FRAX 2JYBA 3FY9X 1AI9A 5HT5A 4X5JA 1RX6A 3LG4A 1M79A 4KJLA 5HSUA 3E0BA 4EIGA 3F0QX 5HSRA 3JWKA 4PTHA 4I13A 4QJZD 1J3KA 1RX7A 5U27A 3JVXA 3DL5A 1S3YA 4KY4A 4P3RA 3GHVA 4EJ1A 4HA9A 3KGYA 3CSEA 2BLAA 3EELA 1U70A 5JG0X 1RB2A 2CIGA 1DLSA 3JWCA 4H98A 4KNEA 4LEKX 3QL0A 3F0BX 1ZDRA 5DFRA 3FQZA 4EIZA 3D80A 1IA2A 3F0XX 1KLKA 1VDRA 3SA1A 3CD2A 1PD8A 3NXYA 4KJJA 3SRQX 3L3RA 4IXGX 2BLCA 4XT5A 1DDRA 3ROAA 1DG8A 3DAUA 4HOGA 1U71A 1M7AA 1AOEA 2FZJA 2W3WA 3CL9A 2W9SA 5EAJA 1RF7A 4P68A 2C2TA 1QZFA 3IA5A 3NRRA 3OCHA 3IRNA
chains in the Genus database with same CATH superfamily
3FYWX 4KAKA 4DPHA 1DR4A 4OR7A 3JWMA 3FL9A 1PD9A 4X5GA 2W9TA 4HOFA 3S7AA 1RX9A 1DIUA 1DREA 1PDBA 3SQYX 3DRCA 1DISA 2ANOA 3QYLA 1JUVA 1CD2A 4HOEA 4G3MA 1DG7A 2O7PA 3GI2A 2W9GA 2HXVA 3FL8A 3FREX 1OHKA 2OIPA 4PSTA 1AO8A 5DXVA 1DYRA 3VCOA 1RG7A 1RX4A 4LAEX 1JOLA 4PDJA 3FY8X 4M7UA 3SRUX 2G6VA 1RX3A 3NXVA 4DP3A 4KY8A 3EEMA 2AZNA 3S9UA 3JW3A 3K45A 1HFPA 3EIGA 3N0HA 3M09A 1DRHA 3JW5A 5HF2X 4M2XA 3NXRA 4KEBA 5HF0X 3F8YA 1BOZA 2QK8A 2DHFA 2INQA 5HQYA 1VJ3A 3I3RA 4KLXA 4CD2A 4ELEA 3FQOA 3FQVA 5HVEA 3K47A 3QLYA 1S3UA 4FHBA 4H96A 1TDRA 4M6KA 1DYJA 3K2HA 3SA2A 2HM9A 3IX9A 3F0UX 5HT4A 3ZPGA 2XW7A 5ECCA 1DR5A 3QFXA 1D1GA 4M6JA 4KM2A 1HFQA 4P66A 7DFRA 1LY4A 1RH3A 3F8ZA 1SEJA 3SRSX 3NXOA 2W3VA 3NZAX 3QG2A 3SGYA 1DR2A 3NZBX 2KGKA 4G95A 5CCCA 2HQPA 1DRAA 3S3VA 1DRBA 4NX6A 3F0VX 4PTJA 2W9HA 1BZFA 4RGCA 1DHJA 1LY3A 1CZ3A 4OSGA 1E26A 4ECKA 3FRBX 3IROA 1RC4A 3GHCA 3JSUA 3SR5X 3RO9A 3IRMA 4H97A 4IXFX 4KM0A 5HI6A 4Q0DA 1RA1A 2D0KA 3UM6A 8DFRA 2L28A 3TQ8A 3NZ9X 4KD7A 1DR3A 4M7VA 3FYVX 3JWFA 3FRDX 3IA4A 3TQ9A 1KMVA 2DRCA 2GD9A 1RX2A 4KJKA 1YHOA 2ZZAA 1RX1A 5JA3A 3EEKA 4ELHA 1DR7A 3NZ6X 4QHVA 3SRWX 1MVTA 5E8QA 4NX7A 4XRBA 1IA4A 1JOMA 3QLZA 4QI9A 2CD2A 4FGGA 4I1NA 3QLXA 2LF1A 5HPBA 2D5NA 1S3WA 3DG8A 2P4GA 5ECXA 3RG9A 3SH2A 1OHJA 4PSYA 1RE7A 3OAFA 4QLFA 3K74A 4XT6A 4QLEA 3NZCX 4HA7A 1DAJA 1DYIA 4M6LA 1M78A 1KMSA 3HBBA 3TD8A 4ELBA 3KJSA 1RA2A 4Q0EA 3FQCA 4XE6X 4KL9A 3TQAA 3FS6A 1RD7A 4QLGA 1DHIA 3GHWA 3DATA 4XT7A 3QLRA 4KYAA 4ELGA 3DGAA 1DYHA 3D84X 5HQZA 1U72A 3UM8A 4G8ZX 3GYFA 4GH8A 6DFRA 3QLWA 3ZPCA 3I8AX 1IA3A 4XT4A 4DPDA 1HFRA 3F91A 3FRFX 3QLSA 3KY8A 1J3IA 5CC9A 2OBCA 2ITHA 1DG5A 3NU0A 1MVSA 1RA9A 2FZIA 4H95A 4KBNA 1RX5A 3UM5A 2BLBA 1IA1A 1RA8A 3JTWA 1RB3A 4ELFA 3QGTA 4XT8A 4PSSA 3DL6A 1RX8A 3Q1HA 5U26A 4XECX 4X5IA 3SRRX 4P3QA 2FZHA 3NXTA 1RA3A 4EILA 3SAIA 4QJCA 1DR1A 2C2SA 4TU5X 3DFRA 3EX8A 4LAHX 3NTZA 3KJRA 2W3MA 3INVA 4DFRA 3KFYA 2BL9A 3M08A 2ANQA 5HUIA 1LUDA 1DF7A 1DLRA 4KFJA 4X5FA 4IXED 1S3VA 4Q67A 3HJ3A 3TQBA 3NZDA 2W3BA 1DHFA 2B3ZA 2W3AA 2H2QA 3FQFA 5HVBA 1J3JA 1DDSA 3EEJA 4FGHA 3CLBA 4Q6AA 1DRFA 3NXXA 3FQ0A 3QL3A 4LAGX 4DDRA 3F0SX 3QYOA 4X5HA 3R33A 5FDAA 1DR6A 3FRAX 2JYBA 3FY9X 1AI9A 5HT5A 4X5JA 1RX6A 3LG4A 1M79A 4KJLA 5HSUA 3E0BA 4EIGA 3F0QX 5HSRA 3JWKA 4PTHA 4I13A 4QJZD 1J3KA 1RX7A 5U27A 3JVXA 3DL5A 1S3YA 4KY4A 4P3RA 3GHVA 4EJ1A 4HA9A 3KGYA 3CSEA 2BLAA 3EELA 1U70A 5JG0X 1RB2A 2CIGA 1DLSA 3JWCA 4H98A 4KNEA 4LEKX 3QL0A 3F0BX 1ZDRA 5DFRA 3FQZA 4EIZA 3D80A 1IA2A 3F0XX 1KLKA 1VDRA 3SA1A 3CD2A 1PD8A 3NXYA 4KJJA 3SRQX 3L3RA 4IXGX 2BLCA 4XT5A 1DDRA 3ROAA 1DG8A 3DAUA 4HOGA 1U71A 1M7AA 1AOEA 2FZJA 2W3WA 3CL9A 2W9SA 5EAJA 1RF7A 4P68A 2C2TA 1QZFA 3IA5A 3NRRA 3OCHA 3IRNA
chains in the Genus database with same CATH topology
3FYWX 4KAKA 4DPHA 1DR4A 4OR7A 3JWMA 3FL9A 1PD9A 4X5GA 2W9TA 4HOFA 3S7AA 1RX9A 1DIUA 1DREA 1PDBA 3SQYX 3DRCA 1DISA 2ANOA 3QYLA 1JUVA 1CD2A 4HOEA 4G3MA 1DG7A 2O7PA 3GI2A 2W9GA 2HXVA 3FL8A 3FREX 1OHKA 2OIPA 4PSTA 1AO8A 5DXVA 1DYRA 3VCOA 1RG7A 1RX4A 4LAEX 1JOLA 4PDJA 3FY8X 4M7UA 3SRUX 2G6VA 1RX3A 3NXVA 4DP3A 4KY8A 3EEMA 2AZNA 3S9UA 3JW3A 3K45A 1HFPA 3EIGA 3N0HA 3M09A 1DRHA 3JW5A 5HF2X 4M2XA 3NXRA 4KEBA 5HF0X 3F8YA 1BOZA 2QK8A 2DHFA 2INQA 5HQYA 1VJ3A 3I3RA 4KLXA 4CD2A 4ELEA 3FQOA 3FQVA 5HVEA 3K47A 3QLYA 1S3UA 4FHBA 4H96A 1TDRA 4M6KA 1DYJA 3K2HA 3SA2A 2HM9A 3IX9A 3F0UX 5HT4A 3ZPGA 2XW7A 5ECCA 1DR5A 3QFXA 1D1GA 4M6JA 4KM2A 1HFQA 4P66A 7DFRA 1LY4A 1RH3A 3F8ZA 1SEJA 3SRSX 3NXOA 2W3VA 3NZAX 3QG2A 3SGYA 1DR2A 3NZBX 2KGKA 4G95A 5CCCA 2HQPA 1DRAA 3S3VA 1DRBA 4NX6A 3F0VX 4PTJA 2W9HA 1BZFA 4RGCA 1DHJA 1LY3A 1CZ3A 4OSGA 1E26A 4ECKA 3FRBX 3IROA 1RC4A 3GHCA 3JSUA 3SR5X 3RO9A 3IRMA 4H97A 4IXFX 4KM0A 5HI6A 4Q0DA 1RA1A 2D0KA 3UM6A 8DFRA 2L28A 3TQ8A 3NZ9X 4KD7A 1DR3A 4M7VA 3FYVX 3JWFA 3FRDX 3IA4A 3TQ9A 1KMVA 2DRCA 2GD9A 1RX2A 4KJKA 1YHOA 2ZZAA 1RX1A 5JA3A 3EEKA 4ELHA 1DR7A 3NZ6X 4QHVA 3SRWX 1MVTA 5E8QA 4NX7A 4XRBA 1IA4A 1JOMA 3QLZA 4QI9A 2CD2A 4FGGA 4I1NA 3QLXA 2LF1A 5HPBA 2D5NA 1S3WA 3DG8A 2P4GA 5ECXA 3RG9A 3SH2A 1OHJA 4PSYA 1RE7A 3OAFA 4QLFA 3K74A 4XT6A 4QLEA 3NZCX 4HA7A 1DAJA 1DYIA 4M6LA 1M78A 1KMSA 3HBBA 3TD8A 4ELBA 3KJSA 1RA2A 4Q0EA 3FQCA 4XE6X 4KL9A 3TQAA 3FS6A 1RD7A 4QLGA 1DHIA 3GHWA 3DATA 4XT7A 3QLRA 4KYAA 4ELGA 3DGAA 1DYHA 3D84X 5HQZA 1U72A 3UM8A 4G8ZX 3GYFA 4GH8A 6DFRA 3QLWA 3ZPCA 3I8AX 1IA3A 4XT4A 4DPDA 1HFRA 3F91A 3FRFX 3QLSA 3KY8A 1J3IA 5CC9A 2OBCA 2ITHA 1DG5A 3NU0A 1MVSA 1RA9A 2FZIA 4H95A 4KBNA 1RX5A 3UM5A 2BLBA 1IA1A 1RA8A 3JTWA 1RB3A 4ELFA 3QGTA 4XT8A 4PSSA 3DL6A 1RX8A 3Q1HA 5U26A 4XECX 4X5IA 3SRRX 4P3QA 2FZHA 3NXTA 1RA3A 4EILA 3SAIA 4QJCA 1DR1A 2C2SA 4TU5X 3DFRA 3EX8A 4LAHX 3NTZA 3KJRA 2W3MA 3INVA 4DFRA 3KFYA 2BL9A 3M08A 2ANQA 5HUIA 1LUDA 1DF7A 1DLRA 4KFJA 4X5FA 4IXED 1S3VA 4Q67A 3HJ3A 3TQBA 3NZDA 2W3BA 1DHFA 2B3ZA 2W3AA 2H2QA 3FQFA 5HVBA 1J3JA 1DDSA 3EEJA 4FGHA 3CLBA 4Q6AA 1DRFA 3NXXA 3FQ0A 3QL3A 4LAGX 4DDRA 3F0SX 3QYOA 4X5HA 3R33A 5FDAA 1DR6A 3FRAX 2JYBA 3FY9X 1AI9A 5HT5A 4X5JA 1RX6A 3LG4A 1M79A 4KJLA 5HSUA 3E0BA 4EIGA 3F0QX 5HSRA 3JWKA 4PTHA 4I13A 4QJZD 1J3KA 1RX7A 5U27A 3JVXA 3DL5A 1S3YA 4KY4A 4P3RA 3GHVA 4EJ1A 4HA9A 3KGYA 3CSEA 2BLAA 3EELA 1U70A 5JG0X 1RB2A 2CIGA 1DLSA 3JWCA 4H98A 4KNEA 4LEKX 3QL0A 3F0BX 1ZDRA 5DFRA 3FQZA 4EIZA 3D80A 1IA2A 3F0XX 1KLKA 1VDRA 3SA1A 3CD2A 1PD8A 3NXYA 4KJJA 3SRQX 3L3RA 4IXGX 2BLCA 4XT5A 1DDRA 3ROAA 1DG8A 3DAUA 4HOGA 1U71A 1M7AA 1AOEA 2FZJA 2W3WA 3CL9A 2W9SA 5EAJA 1RF7A 4P68A 2C2TA 1QZFA 3IA5A 3NRRA 3OCHA 3IRNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FYW X;  4KAK A;  4DPH A;  1DR4 A;  4OR7 A;  3JWM A;  3FL9 A;  1PD9 A;  4X5G A;  2W9T A;  4HOF A;  3S7A A;  1RX9 A;  1DIU A;  1DRE A;  1PDB A;  3SQY X;  3DRC A;  1DIS A;  2ANO A;  3QYL A;  1JUV A;  1CD2 A;  4HOE A;  4G3M A;  1DG7 A;  2O7P A;  3GI2 A;  2W9G A;  2HXV A;  3FL8 A;  3FRE X;  1OHK A;  2OIP A;  4PST A;  1AO8 A;  5DXV A;  1DYR A;  3VCO A;  1RG7 A;  1RX4 A;  4LAE X;  1JOL A;  4PDJ A;  3FY8 X;  4M7U A;  3SRU X;  2G6V A;  1RX3 A;  3NXV A;  4DP3 A;  4KY8 A;  3EEM A;  2AZN A;  3S9U A;  3JW3 A;  3K45 A;  1HFP A;  3EIG A;  3N0H A;  3M09 A;  1DRH A;  3JW5 A;  5HF2 X;  4M2X A;  3NXR A;  4KEB A;  5HF0 X;  3F8Y A;  1BOZ A;  2QK8 A;  2DHF A;  2INQ A;  5HQY A;  1VJ3 A;  3I3R A;  4KLX A;  4CD2 A;  4ELE A;  3FQO A;  3FQV A;  5HVE A;  3K47 A;  3QLY A;  1S3U A;  4FHB A;  4H96 A;  1TDR A;  4M6K A;  1DYJ A;  3K2H A;  3SA2 A;  2HM9 A;  3IX9 A;  3F0U X;  5HT4 A;  3ZPG A;  2XW7 A;  5ECC A;  1DR5 A;  3QFX A;  1D1G A;  4M6J A;  4KM2 A;  1HFQ A;  4P66 A;  7DFR A;  1LY4 A;  1RH3 A;  3F8Z A;  1SEJ A;  3SRS X;  3NXO A;  2W3V A;  3NZA X;  3QG2 A;  3SGY A;  1DR2 A;  3NZB X;  2KGK A;  4G95 A;  5CCC A;  2HQP A;  1DRA A;  3S3V A;  1DRB A;  4NX6 A;  3F0V X;  4PTJ A;  2W9H A;  1BZF A;  4RGC A;  1DHJ A;  1LY3 A;  1CZ3 A;  4OSG A;  1E26 A;  4ECK A;  3FRB X;  3IRO A;  1RC4 A;  3GHC A;  3JSU A;  3SR5 X;  3RO9 A;  3IRM A;  4H97 A;  4IXF X;  4KM0 A;  5HI6 A;  4Q0D A;  1RA1 A;  2D0K A;  3UM6 A;  8DFR A;  2L28 A;  3TQ8 A;  3NZ9 X;  4KD7 A;  1DR3 A;  4M7V A;  3FYV X;  3JWF A;  3FRD X;  3IA4 A;  3TQ9 A;  1KMV A;  2DRC A;  2GD9 A;  1RX2 A;  4KJK A;  1YHO A;  2ZZA A;  1RX1 A;  5JA3 A;  3EEK A;  4ELH A;  1DR7 A;  3NZ6 X;  4QHV A;  3SRW X;  1MVT A;  5E8Q A;  4NX7 A;  4XRB A;  1IA4 A;  1JOM A;  3QLZ A;  4QI9 A;  2CD2 A;  4FGG A;  4I1N A;  3QLX A;  2LF1 A;  5HPB A;  2D5N A;  1S3W A;  3DG8 A;  2P4G A;  5ECX A;  3RG9 A;  3SH2 A;  1OHJ A;  4PSY A;  1RE7 A;  3OAF A;  4QLF A;  3K74 A;  4XT6 A;  4QLE A;  3NZC X;  4HA7 A;  1DAJ A;  1DYI A;  4M6L A;  1M78 A;  1KMS A;  3HBB A;  3TD8 A;  4ELB A;  3KJS A;  1RA2 A;  4Q0E A;  3FQC A;  4XE6 X;  4KL9 A;  3TQA A;  3FS6 A;  1RD7 A;  4QLG A;  1DHI A;  3GHW A;  3DAT A;  4XT7 A;  3QLR A;  4KYA A;  4ELG A;  3DGA A;  1DYH A;  3D84 X;  5HQZ A;  1U72 A;  3UM8 A;  4G8Z X;  3GYF A;  4GH8 A;  6DFR A;  3QLW A;  3ZPC A;  3I8A X;  1IA3 A;  4XT4 A;  4DPD A;  1HFR A;  3F91 A;  3FRF X;  3QLS A;  3KY8 A;  1J3I A;  5CC9 A;  2OBC A;  2ITH A;  1DG5 A;  3NU0 A;  1MVS A;  1RA9 A;  2FZI A;  4H95 A;  4KBN A;  1RX5 A;  3UM5 A;  2BLB A;  1IA1 A;  1RA8 A;  3JTW A;  1RB3 A;  4ELF A;  3QGT A;  4XT8 A;  4PSS A;  3DL6 A;  1RX8 A;  3Q1H A;  5U26 A;  4XEC X;  4X5I A;  3SRR X;  4P3Q A;  2FZH A;  3NXT A;  1RA3 A;  4EIL A;  3SAI A;  4QJC A;  1DR1 A;  2C2S A;  4TU5 X;  3DFR A;  3EX8 A;  4LAH X;  3NTZ A;  3KJR A;  2W3M A;  3INV A;  4DFR A;  3KFY A;  2BL9 A;  3M08 A;  2ANQ A;  5HUI A;  1LUD A;  1DF7 A;  1DLR A;  4KFJ A;  4X5F A;  4IXE D;  1S3V A;  4Q67 A;  3HJ3 A;  3TQB A;  3NZD A;  2W3B A;  1DHF A;  2B3Z A;  2W3A A;  2H2Q A;  3FQF A;  5HVB A;  1J3J A;  1DDS A;  3EEJ A;  4FGH A;  3CLB A;  4Q6A A;  1DRF A;  3NXX A;  3FQ0 A;  3QL3 A;  4LAG X;  4DDR A;  3F0S X;  3QYO A;  4X5H A;  3R33 A;  5FDA A;  1DR6 A;  3FRA X;  2JYB A;  3FY9 X;  1AI9 A;  5HT5 A;  4X5J A;  1RX6 A;  3LG4 A;  1M79 A;  4KJL A;  5HSU A;  3E0B A;  4EIG A;  3F0Q X;  5HSR A;  3JWK A;  4PTH A;  4I13 A;  4QJZ D;  1J3K A;  1RX7 A;  5U27 A;  3JVX A;  3DL5 A;  1S3Y A;  4KY4 A;  4P3R A;  3GHV A;  4EJ1 A;  4HA9 A;  3KGY A;  3CSE A;  2BLA A;  3EEL A;  1U70 A;  5JG0 X;  1RB2 A;  2CIG A;  1DLS A;  3JWC A;  4H98 A;  4KNE A;  4LEK X;  3QL0 A;  3F0B X;  1ZDR A;  5DFR A;  3FQZ A;  4EIZ A;  3D80 A;  1IA2 A;  3F0X X;  1KLK A;  1VDR A;  3SA1 A;  3CD2 A;  1PD8 A;  3NXY A;  4KJJ A;  3SRQ X;  3L3R A;  4IXG X;  2BLC A;  4XT5 A;  1DDR A;  3ROA A;  1DG8 A;  3DAU A;  4HOG A;  1U71 A;  1M7A A;  1AOE A;  2FZJ A;  2W3W A;  3CL9 A;  2W9S A;  5EAJ A;  1RF7 A;  4P68 A;  2C2T A;  1QZF A;  3IA5 A;  3NRR A;  3OCH A;  3IRN A; 
#chains in the Genus database with same CATH topology
 3FYW X;  4KAK A;  4DPH A;  1DR4 A;  4OR7 A;  3JWM A;  3FL9 A;  1PD9 A;  4X5G A;  2W9T A;  4HOF A;  3S7A A;  1RX9 A;  1DIU A;  1DRE A;  1PDB A;  3SQY X;  3DRC A;  1DIS A;  2ANO A;  3QYL A;  1JUV A;  1CD2 A;  4HOE A;  4G3M A;  1DG7 A;  2O7P A;  3GI2 A;  2W9G A;  2HXV A;  3FL8 A;  3FRE X;  1OHK A;  2OIP A;  4PST A;  1AO8 A;  5DXV A;  1DYR A;  3VCO A;  1RG7 A;  1RX4 A;  4LAE X;  1JOL A;  4PDJ A;  3FY8 X;  4M7U A;  3SRU X;  2G6V A;  1RX3 A;  3NXV A;  4DP3 A;  4KY8 A;  3EEM A;  2AZN A;  3S9U A;  3JW3 A;  3K45 A;  1HFP A;  3EIG A;  3N0H A;  3M09 A;  1DRH A;  3JW5 A;  5HF2 X;  4M2X A;  3NXR A;  4KEB A;  5HF0 X;  3F8Y A;  1BOZ A;  2QK8 A;  2DHF A;  2INQ A;  5HQY A;  1VJ3 A;  3I3R A;  4KLX A;  4CD2 A;  4ELE A;  3FQO A;  3FQV A;  5HVE A;  3K47 A;  3QLY A;  1S3U A;  4FHB A;  4H96 A;  1TDR A;  4M6K A;  1DYJ A;  3K2H A;  3SA2 A;  2HM9 A;  3IX9 A;  3F0U X;  5HT4 A;  3ZPG A;  2XW7 A;  5ECC A;  1DR5 A;  3QFX A;  1D1G A;  4M6J A;  4KM2 A;  1HFQ A;  4P66 A;  7DFR A;  1LY4 A;  1RH3 A;  3F8Z A;  1SEJ A;  3SRS X;  3NXO A;  2W3V A;  3NZA X;  3QG2 A;  3SGY A;  1DR2 A;  3NZB X;  2KGK A;  4G95 A;  5CCC A;  2HQP A;  1DRA A;  3S3V A;  1DRB A;  4NX6 A;  3F0V X;  4PTJ A;  2W9H A;  1BZF A;  4RGC A;  1DHJ A;  1LY3 A;  1CZ3 A;  4OSG A;  1E26 A;  4ECK A;  3FRB X;  3IRO A;  1RC4 A;  3GHC A;  3JSU A;  3SR5 X;  3RO9 A;  3IRM A;  4H97 A;  4IXF X;  4KM0 A;  5HI6 A;  4Q0D A;  1RA1 A;  2D0K A;  3UM6 A;  8DFR A;  2L28 A;  3TQ8 A;  3NZ9 X;  4KD7 A;  1DR3 A;  4M7V A;  3FYV X;  3JWF A;  3FRD X;  3IA4 A;  3TQ9 A;  1KMV A;  2DRC A;  2GD9 A;  1RX2 A;  4KJK A;  1YHO A;  2ZZA A;  1RX1 A;  5JA3 A;  3EEK A;  4ELH A;  1DR7 A;  3NZ6 X;  4QHV A;  3SRW X;  1MVT A;  5E8Q A;  4NX7 A;  4XRB A;  1IA4 A;  1JOM A;  3QLZ A;  4QI9 A;  2CD2 A;  4FGG A;  4I1N A;  3QLX A;  2LF1 A;  5HPB A;  2D5N A;  1S3W A;  3DG8 A;  2P4G A;  5ECX A;  3RG9 A;  3SH2 A;  1OHJ A;  4PSY A;  1RE7 A;  3OAF A;  4QLF A;  3K74 A;  4XT6 A;  4QLE A;  3NZC X;  4HA7 A;  1DAJ A;  1DYI A;  4M6L A;  1M78 A;  1KMS A;  3HBB A;  3TD8 A;  4ELB A;  3KJS A;  1RA2 A;  4Q0E A;  3FQC A;  4XE6 X;  4KL9 A;  3TQA A;  3FS6 A;  1RD7 A;  4QLG A;  1DHI A;  3GHW A;  3DAT A;  4XT7 A;  3QLR A;  4KYA A;  4ELG A;  3DGA A;  1DYH A;  3D84 X;  5HQZ A;  1U72 A;  3UM8 A;  4G8Z X;  3GYF A;  4GH8 A;  6DFR A;  3QLW A;  3ZPC A;  3I8A X;  1IA3 A;  4XT4 A;  4DPD A;  1HFR A;  3F91 A;  3FRF X;  3QLS A;  3KY8 A;  1J3I A;  5CC9 A;  2OBC A;  2ITH A;  1DG5 A;  3NU0 A;  1MVS A;  1RA9 A;  2FZI A;  4H95 A;  4KBN A;  1RX5 A;  3UM5 A;  2BLB A;  1IA1 A;  1RA8 A;  3JTW A;  1RB3 A;  4ELF A;  3QGT A;  4XT8 A;  4PSS A;  3DL6 A;  1RX8 A;  3Q1H A;  5U26 A;  4XEC X;  4X5I A;  3SRR X;  4P3Q A;  2FZH A;  3NXT A;  1RA3 A;  4EIL A;  3SAI A;  4QJC A;  1DR1 A;  2C2S A;  4TU5 X;  3DFR A;  3EX8 A;  4LAH X;  3NTZ A;  3KJR A;  2W3M A;  3INV A;  4DFR A;  3KFY A;  2BL9 A;  3M08 A;  2ANQ A;  5HUI A;  1LUD A;  1DF7 A;  1DLR A;  4KFJ A;  4X5F A;  4IXE D;  1S3V A;  4Q67 A;  3HJ3 A;  3TQB A;  3NZD A;  2W3B A;  1DHF A;  2B3Z A;  2W3A A;  2H2Q A;  3FQF A;  5HVB A;  1J3J A;  1DDS A;  3EEJ A;  4FGH A;  3CLB A;  4Q6A A;  1DRF A;  3NXX A;  3FQ0 A;  3QL3 A;  4LAG X;  4DDR A;  3F0S X;  3QYO A;  4X5H A;  3R33 A;  5FDA A;  1DR6 A;  3FRA X;  2JYB A;  3FY9 X;  1AI9 A;  5HT5 A;  4X5J A;  1RX6 A;  3LG4 A;  1M79 A;  4KJL A;  5HSU A;  3E0B A;  4EIG A;  3F0Q X;  5HSR A;  3JWK A;  4PTH A;  4I13 A;  4QJZ D;  1J3K A;  1RX7 A;  5U27 A;  3JVX A;  3DL5 A;  1S3Y A;  4KY4 A;  4P3R A;  3GHV A;  4EJ1 A;  4HA9 A;  3KGY A;  3CSE A;  2BLA A;  3EEL A;  1U70 A;  5JG0 X;  1RB2 A;  2CIG A;  1DLS A;  3JWC A;  4H98 A;  4KNE A;  4LEK X;  3QL0 A;  3F0B X;  1ZDR A;  5DFR A;  3FQZ A;  4EIZ A;  3D80 A;  1IA2 A;  3F0X X;  1KLK A;  1VDR A;  3SA1 A;  3CD2 A;  1PD8 A;  3NXY A;  4KJJ A;  3SRQ X;  3L3R A;  4IXG X;  2BLC A;  4XT5 A;  1DDR A;  3ROA A;  1DG8 A;  3DAU A;  4HOG A;  1U71 A;  1M7A A;  1AOE A;  2FZJ A;  2W3W A;  3CL9 A;  2W9S A;  5EAJ A;  1RF7 A;  4P68 A;  2C2T A;  1QZF A;  3IA5 A;  3NRR A;  3OCH A;  3IRN A; 
#chains in the Genus database with same CATH homology
 3FYW X;  4KAK A;  4DPH A;  1DR4 A;  4OR7 A;  3JWM A;  3FL9 A;  1PD9 A;  4X5G A;  2W9T A;  4HOF A;  3S7A A;  1RX9 A;  1DIU A;  1DRE A;  1PDB A;  3SQY X;  3DRC A;  1DIS A;  2ANO A;  3QYL A;  1JUV A;  1CD2 A;  4HOE A;  4G3M A;  1DG7 A;  2O7P A;  3GI2 A;  2W9G A;  2HXV A;  3FL8 A;  3FRE X;  1OHK A;  2OIP A;  4PST A;  1AO8 A;  5DXV A;  1DYR A;  3VCO A;  1RG7 A;  1RX4 A;  4LAE X;  1JOL A;  4PDJ A;  3FY8 X;  4M7U A;  3SRU X;  2G6V A;  1RX3 A;  3NXV A;  4DP3 A;  4KY8 A;  3EEM A;  2AZN A;  3S9U A;  3JW3 A;  3K45 A;  1HFP A;  3EIG A;  3N0H A;  3M09 A;  1DRH A;  3JW5 A;  5HF2 X;  4M2X A;  3NXR A;  4KEB A;  5HF0 X;  3F8Y A;  1BOZ A;  2QK8 A;  2DHF A;  2INQ A;  5HQY A;  1VJ3 A;  3I3R A;  4KLX A;  4CD2 A;  4ELE A;  3FQO A;  3FQV A;  5HVE A;  3K47 A;  3QLY A;  1S3U A;  4FHB A;  4H96 A;  1TDR A;  4M6K A;  1DYJ A;  3K2H A;  3SA2 A;  2HM9 A;  3IX9 A;  3F0U X;  5HT4 A;  3ZPG A;  2XW7 A;  5ECC A;  1DR5 A;  3QFX A;  1D1G A;  4M6J A;  4KM2 A;  1HFQ A;  4P66 A;  7DFR A;  1LY4 A;  1RH3 A;  3F8Z A;  1SEJ A;  3SRS X;  3NXO A;  2W3V A;  3NZA X;  3QG2 A;  3SGY A;  1DR2 A;  3NZB X;  2KGK A;  4G95 A;  5CCC A;  2HQP A;  1DRA A;  3S3V A;  1DRB A;  4NX6 A;  3F0V X;  4PTJ A;  2W9H A;  1BZF A;  4RGC A;  1DHJ A;  1LY3 A;  1CZ3 A;  4OSG A;  1E26 A;  4ECK A;  3FRB X;  3IRO A;  1RC4 A;  3GHC A;  3JSU A;  3SR5 X;  3RO9 A;  3IRM A;  4H97 A;  4IXF X;  4KM0 A;  5HI6 A;  4Q0D A;  1RA1 A;  2D0K A;  3UM6 A;  8DFR A;  2L28 A;  3TQ8 A;  3NZ9 X;  4KD7 A;  1DR3 A;  4M7V A;  3FYV X;  3JWF A;  3FRD X;  3IA4 A;  3TQ9 A;  1KMV A;  2DRC A;  2GD9 A;  1RX2 A;  4KJK A;  1YHO A;  2ZZA A;  1RX1 A;  5JA3 A;  3EEK A;  4ELH A;  1DR7 A;  3NZ6 X;  4QHV A;  3SRW X;  1MVT A;  5E8Q A;  4NX7 A;  4XRB A;  1IA4 A;  1JOM A;  3QLZ A;  4QI9 A;  2CD2 A;  4FGG A;  4I1N A;  3QLX A;  2LF1 A;  5HPB A;  2D5N A;  1S3W A;  3DG8 A;  2P4G A;  5ECX A;  3RG9 A;  3SH2 A;  1OHJ A;  4PSY A;  1RE7 A;  3OAF A;  4QLF A;  3K74 A;  4XT6 A;  4QLE A;  3NZC X;  4HA7 A;  1DAJ A;  1DYI A;  4M6L A;  1M78 A;  1KMS A;  3HBB A;  3TD8 A;  4ELB A;  3KJS A;  1RA2 A;  4Q0E A;  3FQC A;  4XE6 X;  4KL9 A;  3TQA A;  3FS6 A;  1RD7 A;  4QLG A;  1DHI A;  3GHW A;  3DAT A;  4XT7 A;  3QLR A;  4KYA A;  4ELG A;  3DGA A;  1DYH A;  3D84 X;  5HQZ A;  1U72 A;  3UM8 A;  4G8Z X;  3GYF A;  4GH8 A;  6DFR A;  3QLW A;  3ZPC A;  3I8A X;  1IA3 A;  4XT4 A;  4DPD A;  1HFR A;  3F91 A;  3FRF X;  3QLS A;  3KY8 A;  1J3I A;  5CC9 A;  2OBC A;  2ITH A;  1DG5 A;  3NU0 A;  1MVS A;  1RA9 A;  2FZI A;  4H95 A;  4KBN A;  1RX5 A;  3UM5 A;  2BLB A;  1IA1 A;  1RA8 A;  3JTW A;  1RB3 A;  4ELF A;  3QGT A;  4XT8 A;  4PSS A;  3DL6 A;  1RX8 A;  3Q1H A;  5U26 A;  4XEC X;  4X5I A;  3SRR X;  4P3Q A;  2FZH A;  3NXT A;  1RA3 A;  4EIL A;  3SAI A;  4QJC A;  1DR1 A;  2C2S A;  4TU5 X;  3DFR A;  3EX8 A;  4LAH X;  3NTZ A;  3KJR A;  2W3M A;  3INV A;  4DFR A;  3KFY A;  2BL9 A;  3M08 A;  2ANQ A;  5HUI A;  1LUD A;  1DF7 A;  1DLR A;  4KFJ A;  4X5F A;  4IXE D;  1S3V A;  4Q67 A;  3HJ3 A;  3TQB A;  3NZD A;  2W3B A;  1DHF A;  2B3Z A;  2W3A A;  2H2Q A;  3FQF A;  5HVB A;  1J3J A;  1DDS A;  3EEJ A;  4FGH A;  3CLB A;  4Q6A A;  1DRF A;  3NXX A;  3FQ0 A;  3QL3 A;  4LAG X;  4DDR A;  3F0S X;  3QYO A;  4X5H A;  3R33 A;  5FDA A;  1DR6 A;  3FRA X;  2JYB A;  3FY9 X;  1AI9 A;  5HT5 A;  4X5J A;  1RX6 A;  3LG4 A;  1M79 A;  4KJL A;  5HSU A;  3E0B A;  4EIG A;  3F0Q X;  5HSR A;  3JWK A;  4PTH A;  4I13 A;  4QJZ D;  1J3K A;  1RX7 A;  5U27 A;  3JVX A;  3DL5 A;  1S3Y A;  4KY4 A;  4P3R A;  3GHV A;  4EJ1 A;  4HA9 A;  3KGY A;  3CSE A;  2BLA A;  3EEL A;  1U70 A;  5JG0 X;  1RB2 A;  2CIG A;  1DLS A;  3JWC A;  4H98 A;  4KNE A;  4LEK X;  3QL0 A;  3F0B X;  1ZDR A;  5DFR A;  3FQZ A;  4EIZ A;  3D80 A;  1IA2 A;  3F0X X;  1KLK A;  1VDR A;  3SA1 A;  3CD2 A;  1PD8 A;  3NXY A;  4KJJ A;  3SRQ X;  3L3R A;  4IXG X;  2BLC A;  4XT5 A;  1DDR A;  3ROA A;  1DG8 A;  3DAU A;  4HOG A;  1U71 A;  1M7A A;  1AOE A;  2FZJ A;  2W3W A;  3CL9 A;  2W9S A;  5EAJ A;  1RF7 A;  4P68 A;  2C2T A;  1QZF A;  3IA5 A;  3NRR A;  3OCH A;  3IRN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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