3K47A

Alternate binding modes observed for the e- and z-isomers of 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with nadph and mouse dihydrofolate reductase
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
186
structure length
186
Chain Sequence
VRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Mus musculus
molecule keywords Dihydrofolate reductase
total genus 57
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2009-10-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3k47A00
1ZDRA 3DL6A 3FRDX 3SA2A 3DRCA 3SRUX 7DFRA 4H97A 3GI2A 5HI6A 3K45A 4IXGX 1RX2A 3QL3A 1S3VA 5HVBA 3K74A 3VCOA 3QFXA 3NU0A 3EELA 3F0QX 2ZZAA 4KM0A 3UM5A 4PSYA 1RG7A 1VJ3A 3I8AX 4GH8A 3ZPGA 2BLBA 4KAKA 3NZ6X 3NZCX 2CD2A 3F0BX 1CD2A 2XW7A 5HF0X 4KYAA 3NXRA 1RX1A 2FZHA 3DL5A 1M78A 3GYFA 5HF2X 1RX6A 5HT5A 3CSEA 3QGTA 1CZ3A 4IXED 4XT4A 3K2HA 1DREA 1DR6A 3TQ8A 1S3WA 4M6LA 1QZFA 4X5GA 3M09A 1KLKA 3JW5A 3KGYA 4QLEA 4FGGA 3IA5A 3JW3A 2INQA 2KGKA 3CLBA 3QL0A 1DG8A 1IA4A 1HFQA 5DFRA 3NXOA 2W9SA 3NXVA 4HA9A 2W3AA 2C2TA 5HT4A 1DR4A 3F0UX 3NTZA 3SA1A 4XECX 4KJKA 1DLRA 1DYRA 2GD9A 3EEKA 4H98A 1JOMA 3SR5X 1E26A 4KJJA 3FQCA 1DR7A 2O7PA 2CIGA 3TQAA 4EIZA 4XT5A 3JWKA 4H95A 4PDJA 1RX9A 1RE7A 1RA3A 3RO9A 3SAIA 2G6VA 4TU5X 1YHOA 3EIGA 4LAEX 4EILA 1HFPA 3CL9A 1RH3A 3F0VX 1OHKA 4KM2A 1JUVA 4OSGA 5E8QA 2HXVA 1DR1A 1J3KA 1PDBA 3FYVX 4DFRA 4M2XA 3JWMA 1DYHA 4Q0EA 2C2SA 5DXVA 4M7VA 3E0BA 1KMVA 1PD8A 3QYOA 4P3QA 3FRAX 3RG9A 4KY8A 4DPHA 3F8ZA 4RGCA 4HOGA 4KL9A 4XRBA 1LUDA 3EEMA 5EAJA 3DGAA 1J3JA 5HVEA 1VDRA 2LF1A 1RA9A 3UM8A 3FQ0A 4QLFA 3DG8A 1DRAA 2DRCA 4DPDA 1DDRA 1LY3A 3K47A 4M6JA 1IA3A 3KFYA 4NX6A 1J3IA 3IA4A 1DLSA 1M79A 2W9TA 4Q6AA 3TQ9A 4IXFX 1RA2A 1DIUA 5HUIA 1RX7A 3JWCA 4KY4A 4XE6X 4ELEA 8DFRA 1DR5A 5HQZA 3DAUA 3GHWA 3OAFA 4KFJA 3FQZA 1U70A 3JSUA 2JYBA 3FQVA 3SRSX 3LG4A 5ECCA 2ITHA 1DRHA 3FS6A 4PTJA 3QLZA 3OCHA 1SEJA 3DATA 3QLXA 5U26A 3IRMA 3Q1HA 4QJZD 1RX8A 2W9HA 4HA7A 2FZIA 4FGHA 5HQYA 1HFRA 4ECKA 4PSSA 4ELGA 3CD2A 4DDRA 1RA8A 1S3YA 5HSUA 1M7AA 4G95A 4Q0DA 1DHFA 2D5NA 4X5JA 3QLWA 4X5HA 3F0SX 3FYWX 1RC4A 1BZFA 3QLYA 1AOEA 4EJ1A 1AI9A 3INVA 1RB2A 1U72A 1DYIA 4I13A 2OIPA 1OHJA 5HPBA 4LAHX 3QLSA 3N0HA 1DG7A 3UM6A 2BLAA 3S7AA 1TDRA 1RF7A 3M08A 4H96A 2L28A 2OBCA 2W3BA 3FL8A 3NXXA 3NZDA 1IA2A 3SRWX 3FL9A 4ELHA 4OR7A 1DYJA 3NXTA 4KD7A 3FRFX 4P68A 2ANOA 1S3UA 4XT6A 4X5IA 2ANQA 1DHJA 1AO8A 3F0XX 1D1GA 1RA1A 3HJ3A 4G8ZX 5HSRA 1IA1A 3KJSA 4M7UA 2QK8A 2B3ZA 4QLGA 2DHFA 4PSTA 1LY4A 1U71A 4LAGX 1DRBA 3HBBA 4CD2A 5CC9A 3DFRA 4KJLA 3JWFA 3ROAA 4I1NA 3D84X 4HOFA 1DAJA 4KBNA 3GHVA 3S9UA 1DF7A 4ELFA 5CCCA 3NRRA 3SQYX 3FQOA 2HQPA 1MVTA 3FY9X 4HOEA 4XT7A 3S3VA 3IROA 2D0KA 3QYLA 1RX4A 3IX9A 4KNEA 4QHVA 3GHCA 3IRNA 1RX5A 4M6KA 3SH2A 2P4GA 6DFRA 1KMSA 5JG0X 1RD7A 4P66A 3NZ9X 3F91A 4FHBA 3EEJA 3TQBA 3SRQX 4G3MA 3QG2A 5FDAA 4KEBA 1MVSA 3D80A 4EIGA 2BLCA 1RX3A 1DG5A 4LEKX 3KJRA 3L3RA 3NZAX 4NX7A 4QJCA 3R33A 4X5FA 4ELBA 2W3VA 1RB3A 3SRRX 2AZNA 4XT8A 4DP3A 2FZJA 4PTHA 1DISA 4KLXA 1DRFA 1DHIA 5ECXA 3NZBX 2H2QA 3FREX 2W3MA 3FQFA 2BL9A 3QLRA 2W3WA 3SGYA 3EX8A 3FRBX 1DR2A 1DR3A 4Q67A 3FY8X 1JOLA 3TD8A 5U27A 3I3RA 2W9GA 3F8YA 1BOZA 5JA3A 1PD9A 4QI9A 3ZPCA 3KY8A 4P3RA 3JTWA 3JVXA 1DDSA 2HM9A 3NXYA
chains in the Genus database with same CATH superfamily
1ZDRA 3DL6A 3FRDX 3SA2A 3DRCA 3SRUX 7DFRA 4H97A 3GI2A 5HI6A 3K45A 4IXGX 1RX2A 3QL3A 1S3VA 5HVBA 3K74A 3VCOA 3QFXA 3NU0A 3EELA 3F0QX 2ZZAA 4KM0A 3UM5A 4PSYA 1RG7A 1VJ3A 3I8AX 4GH8A 3ZPGA 2BLBA 4KAKA 3NZ6X 3NZCX 2CD2A 3F0BX 1CD2A 2XW7A 5HF0X 4KYAA 3NXRA 1RX1A 2FZHA 3DL5A 1M78A 3GYFA 5HF2X 1RX6A 5HT5A 3CSEA 3QGTA 1CZ3A 4IXED 4XT4A 3K2HA 1DREA 1DR6A 3TQ8A 1S3WA 4M6LA 1QZFA 4X5GA 3M09A 1KLKA 3JW5A 3KGYA 4QLEA 4FGGA 3IA5A 3JW3A 2INQA 2KGKA 3CLBA 3QL0A 1DG8A 1IA4A 1HFQA 5DFRA 3NXOA 2W9SA 3NXVA 4HA9A 2W3AA 2C2TA 5HT4A 1DR4A 3F0UX 3NTZA 3SA1A 4XECX 4KJKA 1DLRA 1DYRA 2GD9A 3EEKA 4H98A 1JOMA 3SR5X 1E26A 4KJJA 3FQCA 1DR7A 2O7PA 2CIGA 3TQAA 4EIZA 4XT5A 3JWKA 4H95A 4PDJA 1RX9A 1RE7A 1RA3A 3RO9A 3SAIA 2G6VA 4TU5X 1YHOA 3EIGA 4LAEX 4EILA 1HFPA 3CL9A 1RH3A 3F0VX 1OHKA 4KM2A 1JUVA 4OSGA 5E8QA 2HXVA 1DR1A 1J3KA 1PDBA 3FYVX 4DFRA 4M2XA 3JWMA 1DYHA 4Q0EA 2C2SA 5DXVA 4M7VA 3E0BA 1KMVA 1PD8A 3QYOA 4P3QA 3FRAX 3RG9A 4KY8A 4DPHA 3F8ZA 4RGCA 4HOGA 4KL9A 4XRBA 1LUDA 3EEMA 5EAJA 3DGAA 1J3JA 5HVEA 1VDRA 2LF1A 1RA9A 3UM8A 3FQ0A 4QLFA 3DG8A 1DRAA 2DRCA 4DPDA 1DDRA 1LY3A 3K47A 4M6JA 1IA3A 3KFYA 4NX6A 1J3IA 3IA4A 1DLSA 1M79A 2W9TA 4Q6AA 3TQ9A 4IXFX 1RA2A 1DIUA 5HUIA 1RX7A 3JWCA 4KY4A 4XE6X 4ELEA 8DFRA 1DR5A 5HQZA 3DAUA 3GHWA 3OAFA 4KFJA 3FQZA 1U70A 3JSUA 2JYBA 3FQVA 3SRSX 3LG4A 5ECCA 2ITHA 1DRHA 3FS6A 4PTJA 3QLZA 3OCHA 1SEJA 3DATA 3QLXA 5U26A 3IRMA 3Q1HA 4QJZD 1RX8A 2W9HA 4HA7A 2FZIA 4FGHA 5HQYA 1HFRA 4ECKA 4PSSA 4ELGA 3CD2A 4DDRA 1RA8A 1S3YA 5HSUA 1M7AA 4G95A 4Q0DA 1DHFA 2D5NA 4X5JA 3QLWA 4X5HA 3F0SX 3FYWX 1RC4A 1BZFA 3QLYA 1AOEA 4EJ1A 1AI9A 3INVA 1RB2A 1U72A 1DYIA 4I13A 2OIPA 1OHJA 5HPBA 4LAHX 3QLSA 3N0HA 1DG7A 3UM6A 2BLAA 3S7AA 1TDRA 1RF7A 3M08A 4H96A 2L28A 2OBCA 2W3BA 3FL8A 3NXXA 3NZDA 1IA2A 3SRWX 3FL9A 4ELHA 4OR7A 1DYJA 3NXTA 4KD7A 3FRFX 4P68A 2ANOA 1S3UA 4XT6A 4X5IA 2ANQA 1DHJA 1AO8A 3F0XX 1D1GA 1RA1A 3HJ3A 4G8ZX 5HSRA 1IA1A 3KJSA 4M7UA 2QK8A 2B3ZA 4QLGA 2DHFA 4PSTA 1LY4A 1U71A 4LAGX 1DRBA 3HBBA 4CD2A 5CC9A 3DFRA 4KJLA 3JWFA 3ROAA 4I1NA 3D84X 4HOFA 1DAJA 4KBNA 3GHVA 3S9UA 1DF7A 4ELFA 5CCCA 3NRRA 3SQYX 3FQOA 2HQPA 1MVTA 3FY9X 4HOEA 4XT7A 3S3VA 3IROA 2D0KA 3QYLA 1RX4A 3IX9A 4KNEA 4QHVA 3GHCA 3IRNA 1RX5A 4M6KA 3SH2A 2P4GA 6DFRA 1KMSA 5JG0X 1RD7A 4P66A 3NZ9X 3F91A 4FHBA 3EEJA 3TQBA 3SRQX 4G3MA 3QG2A 5FDAA 4KEBA 1MVSA 3D80A 4EIGA 2BLCA 1RX3A 1DG5A 4LEKX 3KJRA 3L3RA 3NZAX 4NX7A 4QJCA 3R33A 4X5FA 4ELBA 2W3VA 1RB3A 3SRRX 2AZNA 4XT8A 4DP3A 2FZJA 4PTHA 1DISA 4KLXA 1DRFA 1DHIA 5ECXA 3NZBX 2H2QA 3FREX 2W3MA 3FQFA 2BL9A 3QLRA 2W3WA 3SGYA 3EX8A 3FRBX 1DR2A 1DR3A 4Q67A 3FY8X 1JOLA 3TD8A 5U27A 3I3RA 2W9GA 3F8YA 1BOZA 5JA3A 1PD9A 4QI9A 3ZPCA 3KY8A 4P3RA 3JTWA 3JVXA 1DDSA 2HM9A 3NXYA
chains in the Genus database with same CATH topology
1ZDRA 3DL6A 3FRDX 3SA2A 3DRCA 3SRUX 7DFRA 4H97A 3GI2A 5HI6A 3K45A 4IXGX 1RX2A 3QL3A 1S3VA 5HVBA 3K74A 3VCOA 3QFXA 3NU0A 3EELA 3F0QX 2ZZAA 4KM0A 3UM5A 4PSYA 1RG7A 1VJ3A 3I8AX 4GH8A 3ZPGA 2BLBA 4KAKA 3NZ6X 3NZCX 2CD2A 3F0BX 1CD2A 2XW7A 5HF0X 4KYAA 3NXRA 1RX1A 2FZHA 3DL5A 1M78A 3GYFA 5HF2X 1RX6A 5HT5A 3CSEA 3QGTA 1CZ3A 4IXED 4XT4A 3K2HA 1DREA 1DR6A 3TQ8A 1S3WA 4M6LA 1QZFA 4X5GA 3M09A 1KLKA 3JW5A 3KGYA 4QLEA 4FGGA 3IA5A 3JW3A 2INQA 2KGKA 3CLBA 3QL0A 1DG8A 1IA4A 1HFQA 5DFRA 3NXOA 2W9SA 3NXVA 4HA9A 2W3AA 2C2TA 5HT4A 1DR4A 3F0UX 3NTZA 3SA1A 4XECX 4KJKA 1DLRA 1DYRA 2GD9A 3EEKA 4H98A 1JOMA 3SR5X 1E26A 4KJJA 3FQCA 1DR7A 2O7PA 2CIGA 3TQAA 4EIZA 4XT5A 3JWKA 4H95A 4PDJA 1RX9A 1RE7A 1RA3A 3RO9A 3SAIA 2G6VA 4TU5X 1YHOA 3EIGA 4LAEX 4EILA 1HFPA 3CL9A 1RH3A 3F0VX 1OHKA 4KM2A 1JUVA 4OSGA 5E8QA 2HXVA 1DR1A 1J3KA 1PDBA 3FYVX 4DFRA 4M2XA 3JWMA 1DYHA 4Q0EA 2C2SA 5DXVA 4M7VA 3E0BA 1KMVA 1PD8A 3QYOA 4P3QA 3FRAX 3RG9A 4KY8A 4DPHA 3F8ZA 4RGCA 4HOGA 4KL9A 4XRBA 1LUDA 3EEMA 5EAJA 3DGAA 1J3JA 5HVEA 1VDRA 2LF1A 1RA9A 3UM8A 3FQ0A 4QLFA 3DG8A 1DRAA 2DRCA 4DPDA 1DDRA 1LY3A 3K47A 4M6JA 1IA3A 3KFYA 4NX6A 1J3IA 3IA4A 1DLSA 1M79A 2W9TA 4Q6AA 3TQ9A 4IXFX 1RA2A 1DIUA 5HUIA 1RX7A 3JWCA 4KY4A 4XE6X 4ELEA 8DFRA 1DR5A 5HQZA 3DAUA 3GHWA 3OAFA 4KFJA 3FQZA 1U70A 3JSUA 2JYBA 3FQVA 3SRSX 3LG4A 5ECCA 2ITHA 1DRHA 3FS6A 4PTJA 3QLZA 3OCHA 1SEJA 3DATA 3QLXA 5U26A 3IRMA 3Q1HA 4QJZD 1RX8A 2W9HA 4HA7A 2FZIA 4FGHA 5HQYA 1HFRA 4ECKA 4PSSA 4ELGA 3CD2A 4DDRA 1RA8A 1S3YA 5HSUA 1M7AA 4G95A 4Q0DA 1DHFA 2D5NA 4X5JA 3QLWA 4X5HA 3F0SX 3FYWX 1RC4A 1BZFA 3QLYA 1AOEA 4EJ1A 1AI9A 3INVA 1RB2A 1U72A 1DYIA 4I13A 2OIPA 1OHJA 5HPBA 4LAHX 3QLSA 3N0HA 1DG7A 3UM6A 2BLAA 3S7AA 1TDRA 1RF7A 3M08A 4H96A 2L28A 2OBCA 2W3BA 3FL8A 3NXXA 3NZDA 1IA2A 3SRWX 3FL9A 4ELHA 4OR7A 1DYJA 3NXTA 4KD7A 3FRFX 4P68A 2ANOA 1S3UA 4XT6A 4X5IA 2ANQA 1DHJA 1AO8A 3F0XX 1D1GA 1RA1A 3HJ3A 4G8ZX 5HSRA 1IA1A 3KJSA 4M7UA 2QK8A 2B3ZA 4QLGA 2DHFA 4PSTA 1LY4A 1U71A 4LAGX 1DRBA 3HBBA 4CD2A 5CC9A 3DFRA 4KJLA 3JWFA 3ROAA 4I1NA 3D84X 4HOFA 1DAJA 4KBNA 3GHVA 3S9UA 1DF7A 4ELFA 5CCCA 3NRRA 3SQYX 3FQOA 2HQPA 1MVTA 3FY9X 4HOEA 4XT7A 3S3VA 3IROA 2D0KA 3QYLA 1RX4A 3IX9A 4KNEA 4QHVA 3GHCA 3IRNA 1RX5A 4M6KA 3SH2A 2P4GA 6DFRA 1KMSA 5JG0X 1RD7A 4P66A 3NZ9X 3F91A 4FHBA 3EEJA 3TQBA 3SRQX 4G3MA 3QG2A 5FDAA 4KEBA 1MVSA 3D80A 4EIGA 2BLCA 1RX3A 1DG5A 4LEKX 3KJRA 3L3RA 3NZAX 4NX7A 4QJCA 3R33A 4X5FA 4ELBA 2W3VA 1RB3A 3SRRX 2AZNA 4XT8A 4DP3A 2FZJA 4PTHA 1DISA 4KLXA 1DRFA 1DHIA 5ECXA 3NZBX 2H2QA 3FREX 2W3MA 3FQFA 2BL9A 3QLRA 2W3WA 3SGYA 3EX8A 3FRBX 1DR2A 1DR3A 4Q67A 3FY8X 1JOLA 3TD8A 5U27A 3I3RA 2W9GA 3F8YA 1BOZA 5JA3A 1PD9A 4QI9A 3ZPCA 3KY8A 4P3RA 3JTWA 3JVXA 1DDSA 2HM9A 3NXYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZDR A;  3DL6 A;  3FRD X;  3SA2 A;  3DRC A;  3SRU X;  7DFR A;  4H97 A;  3GI2 A;  5HI6 A;  3K45 A;  4IXG X;  1RX2 A;  3QL3 A;  1S3V A;  5HVB A;  3K74 A;  3VCO A;  3QFX A;  3NU0 A;  3EEL A;  3F0Q X;  2ZZA A;  4KM0 A;  3UM5 A;  4PSY A;  1RG7 A;  1VJ3 A;  3I8A X;  4GH8 A;  3ZPG A;  2BLB A;  4KAK A;  3NZ6 X;  3NZC X;  2CD2 A;  3F0B X;  1CD2 A;  2XW7 A;  5HF0 X;  4KYA A;  3NXR A;  1RX1 A;  2FZH A;  3DL5 A;  1M78 A;  3GYF A;  5HF2 X;  1RX6 A;  5HT5 A;  3CSE A;  3QGT A;  1CZ3 A;  4IXE D;  4XT4 A;  3K2H A;  1DRE A;  1DR6 A;  3TQ8 A;  1S3W A;  4M6L A;  1QZF A;  4X5G A;  3M09 A;  1KLK A;  3JW5 A;  3KGY A;  4QLE A;  4FGG A;  3IA5 A;  3JW3 A;  2INQ A;  2KGK A;  3CLB A;  3QL0 A;  1DG8 A;  1IA4 A;  1HFQ A;  5DFR A;  3NXO A;  2W9S A;  3NXV A;  4HA9 A;  2W3A A;  2C2T A;  5HT4 A;  1DR4 A;  3F0U X;  3NTZ A;  3SA1 A;  4XEC X;  4KJK A;  1DLR A;  1DYR A;  2GD9 A;  3EEK A;  4H98 A;  1JOM A;  3SR5 X;  1E26 A;  4KJJ A;  3FQC A;  1DR7 A;  2O7P A;  2CIG A;  3TQA A;  4EIZ A;  4XT5 A;  3JWK A;  4H95 A;  4PDJ A;  1RX9 A;  1RE7 A;  1RA3 A;  3RO9 A;  3SAI A;  2G6V A;  4TU5 X;  1YHO A;  3EIG A;  4LAE X;  4EIL A;  1HFP A;  3CL9 A;  1RH3 A;  3F0V X;  1OHK A;  4KM2 A;  1JUV A;  4OSG A;  5E8Q A;  2HXV A;  1DR1 A;  1J3K A;  1PDB A;  3FYV X;  4DFR A;  4M2X A;  3JWM A;  1DYH A;  4Q0E A;  2C2S A;  5DXV A;  4M7V A;  3E0B A;  1KMV A;  1PD8 A;  3QYO A;  4P3Q A;  3FRA X;  3RG9 A;  4KY8 A;  4DPH A;  3F8Z A;  4RGC A;  4HOG A;  4KL9 A;  4XRB A;  1LUD A;  3EEM A;  5EAJ A;  3DGA A;  1J3J A;  5HVE A;  1VDR A;  2LF1 A;  1RA9 A;  3UM8 A;  3FQ0 A;  4QLF A;  3DG8 A;  1DRA A;  2DRC A;  4DPD A;  1DDR A;  1LY3 A;  3K47 A;  4M6J A;  1IA3 A;  3KFY A;  4NX6 A;  1J3I A;  3IA4 A;  1DLS A;  1M79 A;  2W9T A;  4Q6A A;  3TQ9 A;  4IXF X;  1RA2 A;  1DIU A;  5HUI A;  1RX7 A;  3JWC A;  4KY4 A;  4XE6 X;  4ELE A;  8DFR A;  1DR5 A;  5HQZ A;  3DAU A;  3GHW A;  3OAF A;  4KFJ A;  3FQZ A;  1U70 A;  3JSU A;  2JYB A;  3FQV A;  3SRS X;  3LG4 A;  5ECC A;  2ITH A;  1DRH A;  3FS6 A;  4PTJ A;  3QLZ A;  3OCH A;  1SEJ A;  3DAT A;  3QLX A;  5U26 A;  3IRM A;  3Q1H A;  4QJZ D;  1RX8 A;  2W9H A;  4HA7 A;  2FZI A;  4FGH A;  5HQY A;  1HFR A;  4ECK A;  4PSS A;  4ELG A;  3CD2 A;  4DDR A;  1RA8 A;  1S3Y A;  5HSU A;  1M7A A;  4G95 A;  4Q0D A;  1DHF A;  2D5N A;  4X5J A;  3QLW A;  4X5H A;  3F0S X;  3FYW X;  1RC4 A;  1BZF A;  3QLY A;  1AOE A;  4EJ1 A;  1AI9 A;  3INV A;  1RB2 A;  1U72 A;  1DYI A;  4I13 A;  2OIP A;  1OHJ A;  5HPB A;  4LAH X;  3QLS A;  3N0H A;  1DG7 A;  3UM6 A;  2BLA A;  3S7A A;  1TDR A;  1RF7 A;  3M08 A;  4H96 A;  2L28 A;  2OBC A;  2W3B A;  3FL8 A;  3NXX A;  3NZD A;  1IA2 A;  3SRW X;  3FL9 A;  4ELH A;  4OR7 A;  1DYJ A;  3NXT A;  4KD7 A;  3FRF X;  4P68 A;  2ANO A;  1S3U A;  4XT6 A;  4X5I A;  2ANQ A;  1DHJ A;  1AO8 A;  3F0X X;  1D1G A;  1RA1 A;  3HJ3 A;  4G8Z X;  5HSR A;  1IA1 A;  3KJS A;  4M7U A;  2QK8 A;  2B3Z A;  4QLG A;  2DHF A;  4PST A;  1LY4 A;  1U71 A;  4LAG X;  1DRB A;  3HBB A;  4CD2 A;  5CC9 A;  3DFR A;  4KJL A;  3JWF A;  3ROA A;  4I1N A;  3D84 X;  4HOF A;  1DAJ A;  4KBN A;  3GHV A;  3S9U A;  1DF7 A;  4ELF A;  5CCC A;  3NRR A;  3SQY X;  3FQO A;  2HQP A;  1MVT A;  3FY9 X;  4HOE A;  4XT7 A;  3S3V A;  3IRO A;  2D0K A;  3QYL A;  1RX4 A;  3IX9 A;  4KNE A;  4QHV A;  3GHC A;  3IRN A;  1RX5 A;  4M6K A;  3SH2 A;  2P4G A;  6DFR A;  1KMS A;  5JG0 X;  1RD7 A;  4P66 A;  3NZ9 X;  3F91 A;  4FHB A;  3EEJ A;  3TQB A;  3SRQ X;  4G3M A;  3QG2 A;  5FDA A;  4KEB A;  1MVS A;  3D80 A;  4EIG A;  2BLC A;  1RX3 A;  1DG5 A;  4LEK X;  3KJR A;  3L3R A;  3NZA X;  4NX7 A;  4QJC A;  3R33 A;  4X5F A;  4ELB A;  2W3V A;  1RB3 A;  3SRR X;  2AZN A;  4XT8 A;  4DP3 A;  2FZJ A;  4PTH A;  1DIS A;  4KLX A;  1DRF A;  1DHI A;  5ECX A;  3NZB X;  2H2Q A;  3FRE X;  2W3M A;  3FQF A;  2BL9 A;  3QLR A;  2W3W A;  3SGY A;  3EX8 A;  3FRB X;  1DR2 A;  1DR3 A;  4Q67 A;  3FY8 X;  1JOL A;  3TD8 A;  5U27 A;  3I3R A;  2W9G A;  3F8Y A;  1BOZ A;  5JA3 A;  1PD9 A;  4QI9 A;  3ZPC A;  3KY8 A;  4P3R A;  3JTW A;  3JVX A;  1DDS A;  2HM9 A;  3NXY A; 
#chains in the Genus database with same CATH topology
 1ZDR A;  3DL6 A;  3FRD X;  3SA2 A;  3DRC A;  3SRU X;  7DFR A;  4H97 A;  3GI2 A;  5HI6 A;  3K45 A;  4IXG X;  1RX2 A;  3QL3 A;  1S3V A;  5HVB A;  3K74 A;  3VCO A;  3QFX A;  3NU0 A;  3EEL A;  3F0Q X;  2ZZA A;  4KM0 A;  3UM5 A;  4PSY A;  1RG7 A;  1VJ3 A;  3I8A X;  4GH8 A;  3ZPG A;  2BLB A;  4KAK A;  3NZ6 X;  3NZC X;  2CD2 A;  3F0B X;  1CD2 A;  2XW7 A;  5HF0 X;  4KYA A;  3NXR A;  1RX1 A;  2FZH A;  3DL5 A;  1M78 A;  3GYF A;  5HF2 X;  1RX6 A;  5HT5 A;  3CSE A;  3QGT A;  1CZ3 A;  4IXE D;  4XT4 A;  3K2H A;  1DRE A;  1DR6 A;  3TQ8 A;  1S3W A;  4M6L A;  1QZF A;  4X5G A;  3M09 A;  1KLK A;  3JW5 A;  3KGY A;  4QLE A;  4FGG A;  3IA5 A;  3JW3 A;  2INQ A;  2KGK A;  3CLB A;  3QL0 A;  1DG8 A;  1IA4 A;  1HFQ A;  5DFR A;  3NXO A;  2W9S A;  3NXV A;  4HA9 A;  2W3A A;  2C2T A;  5HT4 A;  1DR4 A;  3F0U X;  3NTZ A;  3SA1 A;  4XEC X;  4KJK A;  1DLR A;  1DYR A;  2GD9 A;  3EEK A;  4H98 A;  1JOM A;  3SR5 X;  1E26 A;  4KJJ A;  3FQC A;  1DR7 A;  2O7P A;  2CIG A;  3TQA A;  4EIZ A;  4XT5 A;  3JWK A;  4H95 A;  4PDJ A;  1RX9 A;  1RE7 A;  1RA3 A;  3RO9 A;  3SAI A;  2G6V A;  4TU5 X;  1YHO A;  3EIG A;  4LAE X;  4EIL A;  1HFP A;  3CL9 A;  1RH3 A;  3F0V X;  1OHK A;  4KM2 A;  1JUV A;  4OSG A;  5E8Q A;  2HXV A;  1DR1 A;  1J3K A;  1PDB A;  3FYV X;  4DFR A;  4M2X A;  3JWM A;  1DYH A;  4Q0E A;  2C2S A;  5DXV A;  4M7V A;  3E0B A;  1KMV A;  1PD8 A;  3QYO A;  4P3Q A;  3FRA X;  3RG9 A;  4KY8 A;  4DPH A;  3F8Z A;  4RGC A;  4HOG A;  4KL9 A;  4XRB A;  1LUD A;  3EEM A;  5EAJ A;  3DGA A;  1J3J A;  5HVE A;  1VDR A;  2LF1 A;  1RA9 A;  3UM8 A;  3FQ0 A;  4QLF A;  3DG8 A;  1DRA A;  2DRC A;  4DPD A;  1DDR A;  1LY3 A;  3K47 A;  4M6J A;  1IA3 A;  3KFY A;  4NX6 A;  1J3I A;  3IA4 A;  1DLS A;  1M79 A;  2W9T A;  4Q6A A;  3TQ9 A;  4IXF X;  1RA2 A;  1DIU A;  5HUI A;  1RX7 A;  3JWC A;  4KY4 A;  4XE6 X;  4ELE A;  8DFR A;  1DR5 A;  5HQZ A;  3DAU A;  3GHW A;  3OAF A;  4KFJ A;  3FQZ A;  1U70 A;  3JSU A;  2JYB A;  3FQV A;  3SRS X;  3LG4 A;  5ECC A;  2ITH A;  1DRH A;  3FS6 A;  4PTJ A;  3QLZ A;  3OCH A;  1SEJ A;  3DAT A;  3QLX A;  5U26 A;  3IRM A;  3Q1H A;  4QJZ D;  1RX8 A;  2W9H A;  4HA7 A;  2FZI A;  4FGH A;  5HQY A;  1HFR A;  4ECK A;  4PSS A;  4ELG A;  3CD2 A;  4DDR A;  1RA8 A;  1S3Y A;  5HSU A;  1M7A A;  4G95 A;  4Q0D A;  1DHF A;  2D5N A;  4X5J A;  3QLW A;  4X5H A;  3F0S X;  3FYW X;  1RC4 A;  1BZF A;  3QLY A;  1AOE A;  4EJ1 A;  1AI9 A;  3INV A;  1RB2 A;  1U72 A;  1DYI A;  4I13 A;  2OIP A;  1OHJ A;  5HPB A;  4LAH X;  3QLS A;  3N0H A;  1DG7 A;  3UM6 A;  2BLA A;  3S7A A;  1TDR A;  1RF7 A;  3M08 A;  4H96 A;  2L28 A;  2OBC A;  2W3B A;  3FL8 A;  3NXX A;  3NZD A;  1IA2 A;  3SRW X;  3FL9 A;  4ELH A;  4OR7 A;  1DYJ A;  3NXT A;  4KD7 A;  3FRF X;  4P68 A;  2ANO A;  1S3U A;  4XT6 A;  4X5I A;  2ANQ A;  1DHJ A;  1AO8 A;  3F0X X;  1D1G A;  1RA1 A;  3HJ3 A;  4G8Z X;  5HSR A;  1IA1 A;  3KJS A;  4M7U A;  2QK8 A;  2B3Z A;  4QLG A;  2DHF A;  4PST A;  1LY4 A;  1U71 A;  4LAG X;  1DRB A;  3HBB A;  4CD2 A;  5CC9 A;  3DFR A;  4KJL A;  3JWF A;  3ROA A;  4I1N A;  3D84 X;  4HOF A;  1DAJ A;  4KBN A;  3GHV A;  3S9U A;  1DF7 A;  4ELF A;  5CCC A;  3NRR A;  3SQY X;  3FQO A;  2HQP A;  1MVT A;  3FY9 X;  4HOE A;  4XT7 A;  3S3V A;  3IRO A;  2D0K A;  3QYL A;  1RX4 A;  3IX9 A;  4KNE A;  4QHV A;  3GHC A;  3IRN A;  1RX5 A;  4M6K A;  3SH2 A;  2P4G A;  6DFR A;  1KMS A;  5JG0 X;  1RD7 A;  4P66 A;  3NZ9 X;  3F91 A;  4FHB A;  3EEJ A;  3TQB A;  3SRQ X;  4G3M A;  3QG2 A;  5FDA A;  4KEB A;  1MVS A;  3D80 A;  4EIG A;  2BLC A;  1RX3 A;  1DG5 A;  4LEK X;  3KJR A;  3L3R A;  3NZA X;  4NX7 A;  4QJC A;  3R33 A;  4X5F A;  4ELB A;  2W3V A;  1RB3 A;  3SRR X;  2AZN A;  4XT8 A;  4DP3 A;  2FZJ A;  4PTH A;  1DIS A;  4KLX A;  1DRF A;  1DHI A;  5ECX A;  3NZB X;  2H2Q A;  3FRE X;  2W3M A;  3FQF A;  2BL9 A;  3QLR A;  2W3W A;  3SGY A;  3EX8 A;  3FRB X;  1DR2 A;  1DR3 A;  4Q67 A;  3FY8 X;  1JOL A;  3TD8 A;  5U27 A;  3I3R A;  2W9G A;  3F8Y A;  1BOZ A;  5JA3 A;  1PD9 A;  4QI9 A;  3ZPC A;  3KY8 A;  4P3R A;  3JTW A;  3JVX A;  1DDS A;  2HM9 A;  3NXY A; 
#chains in the Genus database with same CATH homology
 1ZDR A;  3DL6 A;  3FRD X;  3SA2 A;  3DRC A;  3SRU X;  7DFR A;  4H97 A;  3GI2 A;  5HI6 A;  3K45 A;  4IXG X;  1RX2 A;  3QL3 A;  1S3V A;  5HVB A;  3K74 A;  3VCO A;  3QFX A;  3NU0 A;  3EEL A;  3F0Q X;  2ZZA A;  4KM0 A;  3UM5 A;  4PSY A;  1RG7 A;  1VJ3 A;  3I8A X;  4GH8 A;  3ZPG A;  2BLB A;  4KAK A;  3NZ6 X;  3NZC X;  2CD2 A;  3F0B X;  1CD2 A;  2XW7 A;  5HF0 X;  4KYA A;  3NXR A;  1RX1 A;  2FZH A;  3DL5 A;  1M78 A;  3GYF A;  5HF2 X;  1RX6 A;  5HT5 A;  3CSE A;  3QGT A;  1CZ3 A;  4IXE D;  4XT4 A;  3K2H A;  1DRE A;  1DR6 A;  3TQ8 A;  1S3W A;  4M6L A;  1QZF A;  4X5G A;  3M09 A;  1KLK A;  3JW5 A;  3KGY A;  4QLE A;  4FGG A;  3IA5 A;  3JW3 A;  2INQ A;  2KGK A;  3CLB A;  3QL0 A;  1DG8 A;  1IA4 A;  1HFQ A;  5DFR A;  3NXO A;  2W9S A;  3NXV A;  4HA9 A;  2W3A A;  2C2T A;  5HT4 A;  1DR4 A;  3F0U X;  3NTZ A;  3SA1 A;  4XEC X;  4KJK A;  1DLR A;  1DYR A;  2GD9 A;  3EEK A;  4H98 A;  1JOM A;  3SR5 X;  1E26 A;  4KJJ A;  3FQC A;  1DR7 A;  2O7P A;  2CIG A;  3TQA A;  4EIZ A;  4XT5 A;  3JWK A;  4H95 A;  4PDJ A;  1RX9 A;  1RE7 A;  1RA3 A;  3RO9 A;  3SAI A;  2G6V A;  4TU5 X;  1YHO A;  3EIG A;  4LAE X;  4EIL A;  1HFP A;  3CL9 A;  1RH3 A;  3F0V X;  1OHK A;  4KM2 A;  1JUV A;  4OSG A;  5E8Q A;  2HXV A;  1DR1 A;  1J3K A;  1PDB A;  3FYV X;  4DFR A;  4M2X A;  3JWM A;  1DYH A;  4Q0E A;  2C2S A;  5DXV A;  4M7V A;  3E0B A;  1KMV A;  1PD8 A;  3QYO A;  4P3Q A;  3FRA X;  3RG9 A;  4KY8 A;  4DPH A;  3F8Z A;  4RGC A;  4HOG A;  4KL9 A;  4XRB A;  1LUD A;  3EEM A;  5EAJ A;  3DGA A;  1J3J A;  5HVE A;  1VDR A;  2LF1 A;  1RA9 A;  3UM8 A;  3FQ0 A;  4QLF A;  3DG8 A;  1DRA A;  2DRC A;  4DPD A;  1DDR A;  1LY3 A;  3K47 A;  4M6J A;  1IA3 A;  3KFY A;  4NX6 A;  1J3I A;  3IA4 A;  1DLS A;  1M79 A;  2W9T A;  4Q6A A;  3TQ9 A;  4IXF X;  1RA2 A;  1DIU A;  5HUI A;  1RX7 A;  3JWC A;  4KY4 A;  4XE6 X;  4ELE A;  8DFR A;  1DR5 A;  5HQZ A;  3DAU A;  3GHW A;  3OAF A;  4KFJ A;  3FQZ A;  1U70 A;  3JSU A;  2JYB A;  3FQV A;  3SRS X;  3LG4 A;  5ECC A;  2ITH A;  1DRH A;  3FS6 A;  4PTJ A;  3QLZ A;  3OCH A;  1SEJ A;  3DAT A;  3QLX A;  5U26 A;  3IRM A;  3Q1H A;  4QJZ D;  1RX8 A;  2W9H A;  4HA7 A;  2FZI A;  4FGH A;  5HQY A;  1HFR A;  4ECK A;  4PSS A;  4ELG A;  3CD2 A;  4DDR A;  1RA8 A;  1S3Y A;  5HSU A;  1M7A A;  4G95 A;  4Q0D A;  1DHF A;  2D5N A;  4X5J A;  3QLW A;  4X5H A;  3F0S X;  3FYW X;  1RC4 A;  1BZF A;  3QLY A;  1AOE A;  4EJ1 A;  1AI9 A;  3INV A;  1RB2 A;  1U72 A;  1DYI A;  4I13 A;  2OIP A;  1OHJ A;  5HPB A;  4LAH X;  3QLS A;  3N0H A;  1DG7 A;  3UM6 A;  2BLA A;  3S7A A;  1TDR A;  1RF7 A;  3M08 A;  4H96 A;  2L28 A;  2OBC A;  2W3B A;  3FL8 A;  3NXX A;  3NZD A;  1IA2 A;  3SRW X;  3FL9 A;  4ELH A;  4OR7 A;  1DYJ A;  3NXT A;  4KD7 A;  3FRF X;  4P68 A;  2ANO A;  1S3U A;  4XT6 A;  4X5I A;  2ANQ A;  1DHJ A;  1AO8 A;  3F0X X;  1D1G A;  1RA1 A;  3HJ3 A;  4G8Z X;  5HSR A;  1IA1 A;  3KJS A;  4M7U A;  2QK8 A;  2B3Z A;  4QLG A;  2DHF A;  4PST A;  1LY4 A;  1U71 A;  4LAG X;  1DRB A;  3HBB A;  4CD2 A;  5CC9 A;  3DFR A;  4KJL A;  3JWF A;  3ROA A;  4I1N A;  3D84 X;  4HOF A;  1DAJ A;  4KBN A;  3GHV A;  3S9U A;  1DF7 A;  4ELF A;  5CCC A;  3NRR A;  3SQY X;  3FQO A;  2HQP A;  1MVT A;  3FY9 X;  4HOE A;  4XT7 A;  3S3V A;  3IRO A;  2D0K A;  3QYL A;  1RX4 A;  3IX9 A;  4KNE A;  4QHV A;  3GHC A;  3IRN A;  1RX5 A;  4M6K A;  3SH2 A;  2P4G A;  6DFR A;  1KMS A;  5JG0 X;  1RD7 A;  4P66 A;  3NZ9 X;  3F91 A;  4FHB A;  3EEJ A;  3TQB A;  3SRQ X;  4G3M A;  3QG2 A;  5FDA A;  4KEB A;  1MVS A;  3D80 A;  4EIG A;  2BLC A;  1RX3 A;  1DG5 A;  4LEK X;  3KJR A;  3L3R A;  3NZA X;  4NX7 A;  4QJC A;  3R33 A;  4X5F A;  4ELB A;  2W3V A;  1RB3 A;  3SRR X;  2AZN A;  4XT8 A;  4DP3 A;  2FZJ A;  4PTH A;  1DIS A;  4KLX A;  1DRF A;  1DHI A;  5ECX A;  3NZB X;  2H2Q A;  3FRE X;  2W3M A;  3FQF A;  2BL9 A;  3QLR A;  2W3W A;  3SGY A;  3EX8 A;  3FRB X;  1DR2 A;  1DR3 A;  4Q67 A;  3FY8 X;  1JOL A;  3TD8 A;  5U27 A;  3I3R A;  2W9G A;  3F8Y A;  1BOZ A;  5JA3 A;  1PD9 A;  4QI9 A;  3ZPC A;  3KY8 A;  4P3R A;  3JTW A;  3JVX A;  1DDS A;  2HM9 A;  3NXY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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