3L3RA

Structural, computational and kinetic data for antifolate interactions against pneumocystis jirovecii, pneumocystis carinii and human dihydrofolate reductase and their active site mutants
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFKRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 57
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2009-12-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3l3rA00
3CL9A 1CZ3A 3JWKA 3F0BX 3TQ9A 3DL5A 5EAJA 1RX6A 1S3UA 4H95A 4KD7A 5HUIA 3NZCX 2HQPA 5HQYA 3F8YA 2W9TA 1PD8A 3JTWA 5HT4A 4KEBA 1PD9A 5JA3A 2C2SA 4PTHA 2L28A 4XRBA 4RGCA 4KBNA 3NU0A 3JSUA 4P66A 2G6VA 1RA3A 4KJKA 3NXVA 3CLBA 3FRFX 1RX4A 2ITHA 1DR1A 4KM0A 3F0VX 2B3ZA 4OR7A 3FY8X 1DLSA 4X5FA 3K47A 3DATA 3RO9A 3EEKA 3NZBX 3SRWX 1RX8A 3NZ9X 1PDBA 2CD2A 1CD2A 1DG8A 3UM5A 5HF2X 4G95A 3SRSX 1QZFA 4HOEA 3JW5A 2O7PA 1DDSA 1S3YA 1M7AA 2LF1A 4TU5X 4ELHA 4X5IA 4CD2A 5DFRA 4ELBA 3D84X 5HF0X 2D0KA 3ROAA 1VDRA 2DHFA 3TQAA 1RX2A 1DYRA 1J3JA 4KAKA 3VCOA 4M6KA 4QLEA 4KLXA 4KNEA 1DYIA 3FQCA 3FY9X 1IA4A 4X5GA 3EEMA 3DG8A 3S9UA 4M2XA 3NTZA 2AZNA 3QYOA 1KMSA 2W9GA 4LAHX 1DG5A 1U72A 3NZAX 3SAIA 4KJLA 3HJ3A 3FQ0A 4DPHA 2BLCA 2XW7A 5HVEA 1AI9A 1BOZA 1DRFA 1DIUA 3F0UX 4IXFX 1LY4A 3KJSA 3F8ZA 3FRBX 3FL9A 4EIGA 4NX6A 1DHIA 2GD9A 1J3IA 2CIGA 3F0QX 3TD8A 4FGGA 1SEJA 4QLGA 1RB2A 4QLFA 2BL9A 1MVSA 3GHVA 3GYFA 3JVXA 1DRHA 3QGTA 3R33A 3D80A 5HPBA 3DRCA 3OCHA 3KFYA 5U26A 2JYBA 1RX9A 1KLKA 4KFJA 3KJRA 4X5HA 4FGHA 1M78A 4Q67A 3SH2A 2W3MA 2HM9A 2D5NA 4KJJA 1RX1A 2FZHA 3IA5A 3S3VA 4XT5A 4HOGA 2HXVA 1RA8A 3QLZA 1U70A 2BLAA 5HVBA 3EX8A 1LY3A 3F0XX 1U71A 1IA2A 4IXED 1OHKA 2QK8A 4KL9A 2P4GA 3CSEA 3TQ8A 5CCCA 3F91A 2W3BA 3NZDA 4LAEX 4G8ZX 1YHOA 4I1NA 1RH3A 4EIZA 5HI6A 1DRBA 3CD2A 4HA9A 4NX7A 4DFRA 3FYWX 1IA1A 4KM2A 3EIGA 1KMVA 4PSYA 4M7UA 3FRDX 3QLWA 3QFXA 3NRRA 3UM8A 4EILA 2ANQA 1DAJA 4P3QA 5DXVA 3FQVA 1MVTA 4IXGX 3JW3A 1RA2A 4KYAA 4XT8A 4Q6AA 3IRMA 3FQOA 3KGYA 3Q1HA 3SA2A 2DRCA 3SRRX 2ANOA 1AO8A 4DDRA 4PSSA 1RE7A 3IX9A 3I8AX 1AOEA 4P3RA 2W3AA 2W3VA 3UM6A 3EEJA 4XE6X 2H2QA 1LUDA 1TDRA 1HFRA 3QYLA 2FZIA 2OBCA 3ZPCA 4QJZD 4QJCA 3DGAA 4M6JA 3LG4A 3JWFA 3K74A 3FS6A 3S7AA 3IROA 3M08A 3DAUA 4PDJA 3FL8A 5FDAA 4M6LA 3QLXA 4H97A 3SGYA 4FHBA 4EJ1A 4OSGA 3F0SX 1DR2A 4KY4A 1J3KA 1RC4A 1OHJA 3DFRA 3RG9A 3SRUX 3K2HA 2FZJA 4XT6A 4LAGX 3QLSA 4DP3A 1IA3A 3HBBA 4PTJA 4QHVA 4I13A 3FREX 5HSUA 1DR5A 1RX3A 1VJ3A 3IA4A 1DR3A 3I3RA 2C2TA 1S3WA 1DR6A 2W3WA 3EELA 4P68A 1RG7A 1DISA 1DLRA 4ELEA 1RD7A 1RX5A 4HA7A 5HSRA 3FYVX 2W9HA 3NXTA 4XT7A 1DG7A 3L3RA 2ZZAA 4LEKX 1DHJA 3INVA 1DF7A 3SA1A 4GH8A 4KY8A 1DREA 4Q0DA 3QLYA 2W9SA 3FQFA 4ECKA 7DFRA 3QL3A 3FQZA 3K45A 1D1GA 3NXXA 1JUVA 4XECX 5ECXA 4DPDA 1E26A 3GHCA 1HFQA 3TQBA 4H96A 1HFPA 2KGKA 4H98A 1DR4A 1DDRA 4M7VA 5E8QA 3KY8A 1RX7A 4XT4A 1DHFA 1JOLA 3JWCA 3GI2A 4Q0EA 3GHWA 2INQA 4ELFA 1DYJA 3N0HA 5JG0X 3QG2A 1RF7A 4QI9A 3E0BA 3IRNA 2OIPA 1DYHA 5HQZA 1JOMA 4G3MA 4HOFA 4PSTA 3SQYX 1RB3A 3SRQX 1S3VA 1RA1A 1M79A 3DL6A 3NXYA 3SR5X 1BZFA 3QLRA 1RA9A 3M09A 5HT5A 5CC9A 3JWMA 1DR7A 1ZDRA 3ZPGA 8DFRA 3NXOA 4ELGA 3NXRA 4X5JA 1DRAA 6DFRA 3FRAX 2BLBA 5ECCA 3QL0A 5U27A 3NZ6X 3OAFA
chains in the Genus database with same CATH superfamily
3CL9A 1CZ3A 3JWKA 3F0BX 3TQ9A 3DL5A 5EAJA 1RX6A 1S3UA 4H95A 4KD7A 5HUIA 3NZCX 2HQPA 5HQYA 3F8YA 2W9TA 1PD8A 3JTWA 5HT4A 4KEBA 1PD9A 5JA3A 2C2SA 4PTHA 2L28A 4XRBA 4RGCA 4KBNA 3NU0A 3JSUA 4P66A 2G6VA 1RA3A 4KJKA 3NXVA 3CLBA 3FRFX 1RX4A 2ITHA 1DR1A 4KM0A 3F0VX 2B3ZA 4OR7A 3FY8X 1DLSA 4X5FA 3K47A 3DATA 3RO9A 3EEKA 3NZBX 3SRWX 1RX8A 3NZ9X 1PDBA 2CD2A 1CD2A 1DG8A 3UM5A 5HF2X 4G95A 3SRSX 1QZFA 4HOEA 3JW5A 2O7PA 1DDSA 1S3YA 1M7AA 2LF1A 4TU5X 4ELHA 4X5IA 4CD2A 5DFRA 4ELBA 3D84X 5HF0X 2D0KA 3ROAA 1VDRA 2DHFA 3TQAA 1RX2A 1DYRA 1J3JA 4KAKA 3VCOA 4M6KA 4QLEA 4KLXA 4KNEA 1DYIA 3FQCA 3FY9X 1IA4A 4X5GA 3EEMA 3DG8A 3S9UA 4M2XA 3NTZA 2AZNA 3QYOA 1KMSA 2W9GA 4LAHX 1DG5A 1U72A 3NZAX 3SAIA 4KJLA 3HJ3A 3FQ0A 4DPHA 2BLCA 2XW7A 5HVEA 1AI9A 1BOZA 1DRFA 1DIUA 3F0UX 4IXFX 1LY4A 3KJSA 3F8ZA 3FRBX 3FL9A 4EIGA 4NX6A 1DHIA 2GD9A 1J3IA 2CIGA 3F0QX 3TD8A 4FGGA 1SEJA 4QLGA 1RB2A 4QLFA 2BL9A 1MVSA 3GHVA 3GYFA 3JVXA 1DRHA 3QGTA 3R33A 3D80A 5HPBA 3DRCA 3OCHA 3KFYA 5U26A 2JYBA 1RX9A 1KLKA 4KFJA 3KJRA 4X5HA 4FGHA 1M78A 4Q67A 3SH2A 2W3MA 2HM9A 2D5NA 4KJJA 1RX1A 2FZHA 3IA5A 3S3VA 4XT5A 4HOGA 2HXVA 1RA8A 3QLZA 1U70A 2BLAA 5HVBA 3EX8A 1LY3A 3F0XX 1U71A 1IA2A 4IXED 1OHKA 2QK8A 4KL9A 2P4GA 3CSEA 3TQ8A 5CCCA 3F91A 2W3BA 3NZDA 4LAEX 4G8ZX 1YHOA 4I1NA 1RH3A 4EIZA 5HI6A 1DRBA 3CD2A 4HA9A 4NX7A 4DFRA 3FYWX 1IA1A 4KM2A 3EIGA 1KMVA 4PSYA 4M7UA 3FRDX 3QLWA 3QFXA 3NRRA 3UM8A 4EILA 2ANQA 1DAJA 4P3QA 5DXVA 3FQVA 1MVTA 4IXGX 3JW3A 1RA2A 4KYAA 4XT8A 4Q6AA 3IRMA 3FQOA 3KGYA 3Q1HA 3SA2A 2DRCA 3SRRX 2ANOA 1AO8A 4DDRA 4PSSA 1RE7A 3IX9A 3I8AX 1AOEA 4P3RA 2W3AA 2W3VA 3UM6A 3EEJA 4XE6X 2H2QA 1LUDA 1TDRA 1HFRA 3QYLA 2FZIA 2OBCA 3ZPCA 4QJZD 4QJCA 3DGAA 4M6JA 3LG4A 3JWFA 3K74A 3FS6A 3S7AA 3IROA 3M08A 3DAUA 4PDJA 3FL8A 5FDAA 4M6LA 3QLXA 4H97A 3SGYA 4FHBA 4EJ1A 4OSGA 3F0SX 1DR2A 4KY4A 1J3KA 1RC4A 1OHJA 3DFRA 3RG9A 3SRUX 3K2HA 2FZJA 4XT6A 4LAGX 3QLSA 4DP3A 1IA3A 3HBBA 4PTJA 4QHVA 4I13A 3FREX 5HSUA 1DR5A 1RX3A 1VJ3A 3IA4A 1DR3A 3I3RA 2C2TA 1S3WA 1DR6A 2W3WA 3EELA 4P68A 1RG7A 1DISA 1DLRA 4ELEA 1RD7A 1RX5A 4HA7A 5HSRA 3FYVX 2W9HA 3NXTA 4XT7A 1DG7A 3L3RA 2ZZAA 4LEKX 1DHJA 3INVA 1DF7A 3SA1A 4GH8A 4KY8A 1DREA 4Q0DA 3QLYA 2W9SA 3FQFA 4ECKA 7DFRA 3QL3A 3FQZA 3K45A 1D1GA 3NXXA 1JUVA 4XECX 5ECXA 4DPDA 1E26A 3GHCA 1HFQA 3TQBA 4H96A 1HFPA 2KGKA 4H98A 1DR4A 1DDRA 4M7VA 5E8QA 3KY8A 1RX7A 4XT4A 1DHFA 1JOLA 3JWCA 3GI2A 4Q0EA 3GHWA 2INQA 4ELFA 1DYJA 3N0HA 5JG0X 3QG2A 1RF7A 4QI9A 3E0BA 3IRNA 2OIPA 1DYHA 5HQZA 1JOMA 4G3MA 4HOFA 4PSTA 3SQYX 1RB3A 3SRQX 1S3VA 1RA1A 1M79A 3DL6A 3NXYA 3SR5X 1BZFA 3QLRA 1RA9A 3M09A 5HT5A 5CC9A 3JWMA 1DR7A 1ZDRA 3ZPGA 8DFRA 3NXOA 4ELGA 3NXRA 4X5JA 1DRAA 6DFRA 3FRAX 2BLBA 5ECCA 3QL0A 5U27A 3NZ6X 3OAFA
chains in the Genus database with same CATH topology
3CL9A 1CZ3A 3JWKA 3F0BX 3TQ9A 3DL5A 5EAJA 1RX6A 1S3UA 4H95A 4KD7A 5HUIA 3NZCX 2HQPA 5HQYA 3F8YA 2W9TA 1PD8A 3JTWA 5HT4A 4KEBA 1PD9A 5JA3A 2C2SA 4PTHA 2L28A 4XRBA 4RGCA 4KBNA 3NU0A 3JSUA 4P66A 2G6VA 1RA3A 4KJKA 3NXVA 3CLBA 3FRFX 1RX4A 2ITHA 1DR1A 4KM0A 3F0VX 2B3ZA 4OR7A 3FY8X 1DLSA 4X5FA 3K47A 3DATA 3RO9A 3EEKA 3NZBX 3SRWX 1RX8A 3NZ9X 1PDBA 2CD2A 1CD2A 1DG8A 3UM5A 5HF2X 4G95A 3SRSX 1QZFA 4HOEA 3JW5A 2O7PA 1DDSA 1S3YA 1M7AA 2LF1A 4TU5X 4ELHA 4X5IA 4CD2A 5DFRA 4ELBA 3D84X 5HF0X 2D0KA 3ROAA 1VDRA 2DHFA 3TQAA 1RX2A 1DYRA 1J3JA 4KAKA 3VCOA 4M6KA 4QLEA 4KLXA 4KNEA 1DYIA 3FQCA 3FY9X 1IA4A 4X5GA 3EEMA 3DG8A 3S9UA 4M2XA 3NTZA 2AZNA 3QYOA 1KMSA 2W9GA 4LAHX 1DG5A 1U72A 3NZAX 3SAIA 4KJLA 3HJ3A 3FQ0A 4DPHA 2BLCA 2XW7A 5HVEA 1AI9A 1BOZA 1DRFA 1DIUA 3F0UX 4IXFX 1LY4A 3KJSA 3F8ZA 3FRBX 3FL9A 4EIGA 4NX6A 1DHIA 2GD9A 1J3IA 2CIGA 3F0QX 3TD8A 4FGGA 1SEJA 4QLGA 1RB2A 4QLFA 2BL9A 1MVSA 3GHVA 3GYFA 3JVXA 1DRHA 3QGTA 3R33A 3D80A 5HPBA 3DRCA 3OCHA 3KFYA 5U26A 2JYBA 1RX9A 1KLKA 4KFJA 3KJRA 4X5HA 4FGHA 1M78A 4Q67A 3SH2A 2W3MA 2HM9A 2D5NA 4KJJA 1RX1A 2FZHA 3IA5A 3S3VA 4XT5A 4HOGA 2HXVA 1RA8A 3QLZA 1U70A 2BLAA 5HVBA 3EX8A 1LY3A 3F0XX 1U71A 1IA2A 4IXED 1OHKA 2QK8A 4KL9A 2P4GA 3CSEA 3TQ8A 5CCCA 3F91A 2W3BA 3NZDA 4LAEX 4G8ZX 1YHOA 4I1NA 1RH3A 4EIZA 5HI6A 1DRBA 3CD2A 4HA9A 4NX7A 4DFRA 3FYWX 1IA1A 4KM2A 3EIGA 1KMVA 4PSYA 4M7UA 3FRDX 3QLWA 3QFXA 3NRRA 3UM8A 4EILA 2ANQA 1DAJA 4P3QA 5DXVA 3FQVA 1MVTA 4IXGX 3JW3A 1RA2A 4KYAA 4XT8A 4Q6AA 3IRMA 3FQOA 3KGYA 3Q1HA 3SA2A 2DRCA 3SRRX 2ANOA 1AO8A 4DDRA 4PSSA 1RE7A 3IX9A 3I8AX 1AOEA 4P3RA 2W3AA 2W3VA 3UM6A 3EEJA 4XE6X 2H2QA 1LUDA 1TDRA 1HFRA 3QYLA 2FZIA 2OBCA 3ZPCA 4QJZD 4QJCA 3DGAA 4M6JA 3LG4A 3JWFA 3K74A 3FS6A 3S7AA 3IROA 3M08A 3DAUA 4PDJA 3FL8A 5FDAA 4M6LA 3QLXA 4H97A 3SGYA 4FHBA 4EJ1A 4OSGA 3F0SX 1DR2A 4KY4A 1J3KA 1RC4A 1OHJA 3DFRA 3RG9A 3SRUX 3K2HA 2FZJA 4XT6A 4LAGX 3QLSA 4DP3A 1IA3A 3HBBA 4PTJA 4QHVA 4I13A 3FREX 5HSUA 1DR5A 1RX3A 1VJ3A 3IA4A 1DR3A 3I3RA 2C2TA 1S3WA 1DR6A 2W3WA 3EELA 4P68A 1RG7A 1DISA 1DLRA 4ELEA 1RD7A 1RX5A 4HA7A 5HSRA 3FYVX 2W9HA 3NXTA 4XT7A 1DG7A 3L3RA 2ZZAA 4LEKX 1DHJA 3INVA 1DF7A 3SA1A 4GH8A 4KY8A 1DREA 4Q0DA 3QLYA 2W9SA 3FQFA 4ECKA 7DFRA 3QL3A 3FQZA 3K45A 1D1GA 3NXXA 1JUVA 4XECX 5ECXA 4DPDA 1E26A 3GHCA 1HFQA 3TQBA 4H96A 1HFPA 2KGKA 4H98A 1DR4A 1DDRA 4M7VA 5E8QA 3KY8A 1RX7A 4XT4A 1DHFA 1JOLA 3JWCA 3GI2A 4Q0EA 3GHWA 2INQA 4ELFA 1DYJA 3N0HA 5JG0X 3QG2A 1RF7A 4QI9A 3E0BA 3IRNA 2OIPA 1DYHA 5HQZA 1JOMA 4G3MA 4HOFA 4PSTA 3SQYX 1RB3A 3SRQX 1S3VA 1RA1A 1M79A 3DL6A 3NXYA 3SR5X 1BZFA 3QLRA 1RA9A 3M09A 5HT5A 5CC9A 3JWMA 1DR7A 1ZDRA 3ZPGA 8DFRA 3NXOA 4ELGA 3NXRA 4X5JA 1DRAA 6DFRA 3FRAX 2BLBA 5ECCA 3QL0A 5U27A 3NZ6X 3OAFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CL9 A;  1CZ3 A;  3JWK A;  3F0B X;  3TQ9 A;  3DL5 A;  5EAJ A;  1RX6 A;  1S3U A;  4H95 A;  4KD7 A;  5HUI A;  3NZC X;  2HQP A;  5HQY A;  3F8Y A;  2W9T A;  1PD8 A;  3JTW A;  5HT4 A;  4KEB A;  1PD9 A;  5JA3 A;  2C2S A;  4PTH A;  2L28 A;  4XRB A;  4RGC A;  4KBN A;  3NU0 A;  3JSU A;  4P66 A;  2G6V A;  1RA3 A;  4KJK A;  3NXV A;  3CLB A;  3FRF X;  1RX4 A;  2ITH A;  1DR1 A;  4KM0 A;  3F0V X;  2B3Z A;  4OR7 A;  3FY8 X;  1DLS A;  4X5F A;  3K47 A;  3DAT A;  3RO9 A;  3EEK A;  3NZB X;  3SRW X;  1RX8 A;  3NZ9 X;  1PDB A;  2CD2 A;  1CD2 A;  1DG8 A;  3UM5 A;  5HF2 X;  4G95 A;  3SRS X;  1QZF A;  4HOE A;  3JW5 A;  2O7P A;  1DDS A;  1S3Y A;  1M7A A;  2LF1 A;  4TU5 X;  4ELH A;  4X5I A;  4CD2 A;  5DFR A;  4ELB A;  3D84 X;  5HF0 X;  2D0K A;  3ROA A;  1VDR A;  2DHF A;  3TQA A;  1RX2 A;  1DYR A;  1J3J A;  4KAK A;  3VCO A;  4M6K A;  4QLE A;  4KLX A;  4KNE A;  1DYI A;  3FQC A;  3FY9 X;  1IA4 A;  4X5G A;  3EEM A;  3DG8 A;  3S9U A;  4M2X A;  3NTZ A;  2AZN A;  3QYO A;  1KMS A;  2W9G A;  4LAH X;  1DG5 A;  1U72 A;  3NZA X;  3SAI A;  4KJL A;  3HJ3 A;  3FQ0 A;  4DPH A;  2BLC A;  2XW7 A;  5HVE A;  1AI9 A;  1BOZ A;  1DRF A;  1DIU A;  3F0U X;  4IXF X;  1LY4 A;  3KJS A;  3F8Z A;  3FRB X;  3FL9 A;  4EIG A;  4NX6 A;  1DHI A;  2GD9 A;  1J3I A;  2CIG A;  3F0Q X;  3TD8 A;  4FGG A;  1SEJ A;  4QLG A;  1RB2 A;  4QLF A;  2BL9 A;  1MVS A;  3GHV A;  3GYF A;  3JVX A;  1DRH A;  3QGT A;  3R33 A;  3D80 A;  5HPB A;  3DRC A;  3OCH A;  3KFY A;  5U26 A;  2JYB A;  1RX9 A;  1KLK A;  4KFJ A;  3KJR A;  4X5H A;  4FGH A;  1M78 A;  4Q67 A;  3SH2 A;  2W3M A;  2HM9 A;  2D5N A;  4KJJ A;  1RX1 A;  2FZH A;  3IA5 A;  3S3V A;  4XT5 A;  4HOG A;  2HXV A;  1RA8 A;  3QLZ A;  1U70 A;  2BLA A;  5HVB A;  3EX8 A;  1LY3 A;  3F0X X;  1U71 A;  1IA2 A;  4IXE D;  1OHK A;  2QK8 A;  4KL9 A;  2P4G A;  3CSE A;  3TQ8 A;  5CCC A;  3F91 A;  2W3B A;  3NZD A;  4LAE X;  4G8Z X;  1YHO A;  4I1N A;  1RH3 A;  4EIZ A;  5HI6 A;  1DRB A;  3CD2 A;  4HA9 A;  4NX7 A;  4DFR A;  3FYW X;  1IA1 A;  4KM2 A;  3EIG A;  1KMV A;  4PSY A;  4M7U A;  3FRD X;  3QLW A;  3QFX A;  3NRR A;  3UM8 A;  4EIL A;  2ANQ A;  1DAJ A;  4P3Q A;  5DXV A;  3FQV A;  1MVT A;  4IXG X;  3JW3 A;  1RA2 A;  4KYA A;  4XT8 A;  4Q6A A;  3IRM A;  3FQO A;  3KGY A;  3Q1H A;  3SA2 A;  2DRC A;  3SRR X;  2ANO A;  1AO8 A;  4DDR A;  4PSS A;  1RE7 A;  3IX9 A;  3I8A X;  1AOE A;  4P3R A;  2W3A A;  2W3V A;  3UM6 A;  3EEJ A;  4XE6 X;  2H2Q A;  1LUD A;  1TDR A;  1HFR A;  3QYL A;  2FZI A;  2OBC A;  3ZPC A;  4QJZ D;  4QJC A;  3DGA A;  4M6J A;  3LG4 A;  3JWF A;  3K74 A;  3FS6 A;  3S7A A;  3IRO A;  3M08 A;  3DAU A;  4PDJ A;  3FL8 A;  5FDA A;  4M6L A;  3QLX A;  4H97 A;  3SGY A;  4FHB A;  4EJ1 A;  4OSG A;  3F0S X;  1DR2 A;  4KY4 A;  1J3K A;  1RC4 A;  1OHJ A;  3DFR A;  3RG9 A;  3SRU X;  3K2H A;  2FZJ A;  4XT6 A;  4LAG X;  3QLS A;  4DP3 A;  1IA3 A;  3HBB A;  4PTJ A;  4QHV A;  4I13 A;  3FRE X;  5HSU A;  1DR5 A;  1RX3 A;  1VJ3 A;  3IA4 A;  1DR3 A;  3I3R A;  2C2T A;  1S3W A;  1DR6 A;  2W3W A;  3EEL A;  4P68 A;  1RG7 A;  1DIS A;  1DLR A;  4ELE A;  1RD7 A;  1RX5 A;  4HA7 A;  5HSR A;  3FYV X;  2W9H A;  3NXT A;  4XT7 A;  1DG7 A;  3L3R A;  2ZZA A;  4LEK X;  1DHJ A;  3INV A;  1DF7 A;  3SA1 A;  4GH8 A;  4KY8 A;  1DRE A;  4Q0D A;  3QLY A;  2W9S A;  3FQF A;  4ECK A;  7DFR A;  3QL3 A;  3FQZ A;  3K45 A;  1D1G A;  3NXX A;  1JUV A;  4XEC X;  5ECX A;  4DPD A;  1E26 A;  3GHC A;  1HFQ A;  3TQB A;  4H96 A;  1HFP A;  2KGK A;  4H98 A;  1DR4 A;  1DDR A;  4M7V A;  5E8Q A;  3KY8 A;  1RX7 A;  4XT4 A;  1DHF A;  1JOL A;  3JWC A;  3GI2 A;  4Q0E A;  3GHW A;  2INQ A;  4ELF A;  1DYJ A;  3N0H A;  5JG0 X;  3QG2 A;  1RF7 A;  4QI9 A;  3E0B A;  3IRN A;  2OIP A;  1DYH A;  5HQZ A;  1JOM A;  4G3M A;  4HOF A;  4PST A;  3SQY X;  1RB3 A;  3SRQ X;  1S3V A;  1RA1 A;  1M79 A;  3DL6 A;  3NXY A;  3SR5 X;  1BZF A;  3QLR A;  1RA9 A;  3M09 A;  5HT5 A;  5CC9 A;  3JWM A;  1DR7 A;  1ZDR A;  3ZPG A;  8DFR A;  3NXO A;  4ELG A;  3NXR A;  4X5J A;  1DRA A;  6DFR A;  3FRA X;  2BLB A;  5ECC A;  3QL0 A;  5U27 A;  3NZ6 X;  3OAF A; 
#chains in the Genus database with same CATH topology
 3CL9 A;  1CZ3 A;  3JWK A;  3F0B X;  3TQ9 A;  3DL5 A;  5EAJ A;  1RX6 A;  1S3U A;  4H95 A;  4KD7 A;  5HUI A;  3NZC X;  2HQP A;  5HQY A;  3F8Y A;  2W9T A;  1PD8 A;  3JTW A;  5HT4 A;  4KEB A;  1PD9 A;  5JA3 A;  2C2S A;  4PTH A;  2L28 A;  4XRB A;  4RGC A;  4KBN A;  3NU0 A;  3JSU A;  4P66 A;  2G6V A;  1RA3 A;  4KJK A;  3NXV A;  3CLB A;  3FRF X;  1RX4 A;  2ITH A;  1DR1 A;  4KM0 A;  3F0V X;  2B3Z A;  4OR7 A;  3FY8 X;  1DLS A;  4X5F A;  3K47 A;  3DAT A;  3RO9 A;  3EEK A;  3NZB X;  3SRW X;  1RX8 A;  3NZ9 X;  1PDB A;  2CD2 A;  1CD2 A;  1DG8 A;  3UM5 A;  5HF2 X;  4G95 A;  3SRS X;  1QZF A;  4HOE A;  3JW5 A;  2O7P A;  1DDS A;  1S3Y A;  1M7A A;  2LF1 A;  4TU5 X;  4ELH A;  4X5I A;  4CD2 A;  5DFR A;  4ELB A;  3D84 X;  5HF0 X;  2D0K A;  3ROA A;  1VDR A;  2DHF A;  3TQA A;  1RX2 A;  1DYR A;  1J3J A;  4KAK A;  3VCO A;  4M6K A;  4QLE A;  4KLX A;  4KNE A;  1DYI A;  3FQC A;  3FY9 X;  1IA4 A;  4X5G A;  3EEM A;  3DG8 A;  3S9U A;  4M2X A;  3NTZ A;  2AZN A;  3QYO A;  1KMS A;  2W9G A;  4LAH X;  1DG5 A;  1U72 A;  3NZA X;  3SAI A;  4KJL A;  3HJ3 A;  3FQ0 A;  4DPH A;  2BLC A;  2XW7 A;  5HVE A;  1AI9 A;  1BOZ A;  1DRF A;  1DIU A;  3F0U X;  4IXF X;  1LY4 A;  3KJS A;  3F8Z A;  3FRB X;  3FL9 A;  4EIG A;  4NX6 A;  1DHI A;  2GD9 A;  1J3I A;  2CIG A;  3F0Q X;  3TD8 A;  4FGG A;  1SEJ A;  4QLG A;  1RB2 A;  4QLF A;  2BL9 A;  1MVS A;  3GHV A;  3GYF A;  3JVX A;  1DRH A;  3QGT A;  3R33 A;  3D80 A;  5HPB A;  3DRC A;  3OCH A;  3KFY A;  5U26 A;  2JYB A;  1RX9 A;  1KLK A;  4KFJ A;  3KJR A;  4X5H A;  4FGH A;  1M78 A;  4Q67 A;  3SH2 A;  2W3M A;  2HM9 A;  2D5N A;  4KJJ A;  1RX1 A;  2FZH A;  3IA5 A;  3S3V A;  4XT5 A;  4HOG A;  2HXV A;  1RA8 A;  3QLZ A;  1U70 A;  2BLA A;  5HVB A;  3EX8 A;  1LY3 A;  3F0X X;  1U71 A;  1IA2 A;  4IXE D;  1OHK A;  2QK8 A;  4KL9 A;  2P4G A;  3CSE A;  3TQ8 A;  5CCC A;  3F91 A;  2W3B A;  3NZD A;  4LAE X;  4G8Z X;  1YHO A;  4I1N A;  1RH3 A;  4EIZ A;  5HI6 A;  1DRB A;  3CD2 A;  4HA9 A;  4NX7 A;  4DFR A;  3FYW X;  1IA1 A;  4KM2 A;  3EIG A;  1KMV A;  4PSY A;  4M7U A;  3FRD X;  3QLW A;  3QFX A;  3NRR A;  3UM8 A;  4EIL A;  2ANQ A;  1DAJ A;  4P3Q A;  5DXV A;  3FQV A;  1MVT A;  4IXG X;  3JW3 A;  1RA2 A;  4KYA A;  4XT8 A;  4Q6A A;  3IRM A;  3FQO A;  3KGY A;  3Q1H A;  3SA2 A;  2DRC A;  3SRR X;  2ANO A;  1AO8 A;  4DDR A;  4PSS A;  1RE7 A;  3IX9 A;  3I8A X;  1AOE A;  4P3R A;  2W3A A;  2W3V A;  3UM6 A;  3EEJ A;  4XE6 X;  2H2Q A;  1LUD A;  1TDR A;  1HFR A;  3QYL A;  2FZI A;  2OBC A;  3ZPC A;  4QJZ D;  4QJC A;  3DGA A;  4M6J A;  3LG4 A;  3JWF A;  3K74 A;  3FS6 A;  3S7A A;  3IRO A;  3M08 A;  3DAU A;  4PDJ A;  3FL8 A;  5FDA A;  4M6L A;  3QLX A;  4H97 A;  3SGY A;  4FHB A;  4EJ1 A;  4OSG A;  3F0S X;  1DR2 A;  4KY4 A;  1J3K A;  1RC4 A;  1OHJ A;  3DFR A;  3RG9 A;  3SRU X;  3K2H A;  2FZJ A;  4XT6 A;  4LAG X;  3QLS A;  4DP3 A;  1IA3 A;  3HBB A;  4PTJ A;  4QHV A;  4I13 A;  3FRE X;  5HSU A;  1DR5 A;  1RX3 A;  1VJ3 A;  3IA4 A;  1DR3 A;  3I3R A;  2C2T A;  1S3W A;  1DR6 A;  2W3W A;  3EEL A;  4P68 A;  1RG7 A;  1DIS A;  1DLR A;  4ELE A;  1RD7 A;  1RX5 A;  4HA7 A;  5HSR A;  3FYV X;  2W9H A;  3NXT A;  4XT7 A;  1DG7 A;  3L3R A;  2ZZA A;  4LEK X;  1DHJ A;  3INV A;  1DF7 A;  3SA1 A;  4GH8 A;  4KY8 A;  1DRE A;  4Q0D A;  3QLY A;  2W9S A;  3FQF A;  4ECK A;  7DFR A;  3QL3 A;  3FQZ A;  3K45 A;  1D1G A;  3NXX A;  1JUV A;  4XEC X;  5ECX A;  4DPD A;  1E26 A;  3GHC A;  1HFQ A;  3TQB A;  4H96 A;  1HFP A;  2KGK A;  4H98 A;  1DR4 A;  1DDR A;  4M7V A;  5E8Q A;  3KY8 A;  1RX7 A;  4XT4 A;  1DHF A;  1JOL A;  3JWC A;  3GI2 A;  4Q0E A;  3GHW A;  2INQ A;  4ELF A;  1DYJ A;  3N0H A;  5JG0 X;  3QG2 A;  1RF7 A;  4QI9 A;  3E0B A;  3IRN A;  2OIP A;  1DYH A;  5HQZ A;  1JOM A;  4G3M A;  4HOF A;  4PST A;  3SQY X;  1RB3 A;  3SRQ X;  1S3V A;  1RA1 A;  1M79 A;  3DL6 A;  3NXY A;  3SR5 X;  1BZF A;  3QLR A;  1RA9 A;  3M09 A;  5HT5 A;  5CC9 A;  3JWM A;  1DR7 A;  1ZDR A;  3ZPG A;  8DFR A;  3NXO A;  4ELG A;  3NXR A;  4X5J A;  1DRA A;  6DFR A;  3FRA X;  2BLB A;  5ECC A;  3QL0 A;  5U27 A;  3NZ6 X;  3OAF A; 
#chains in the Genus database with same CATH homology
 3CL9 A;  1CZ3 A;  3JWK A;  3F0B X;  3TQ9 A;  3DL5 A;  5EAJ A;  1RX6 A;  1S3U A;  4H95 A;  4KD7 A;  5HUI A;  3NZC X;  2HQP A;  5HQY A;  3F8Y A;  2W9T A;  1PD8 A;  3JTW A;  5HT4 A;  4KEB A;  1PD9 A;  5JA3 A;  2C2S A;  4PTH A;  2L28 A;  4XRB A;  4RGC A;  4KBN A;  3NU0 A;  3JSU A;  4P66 A;  2G6V A;  1RA3 A;  4KJK A;  3NXV A;  3CLB A;  3FRF X;  1RX4 A;  2ITH A;  1DR1 A;  4KM0 A;  3F0V X;  2B3Z A;  4OR7 A;  3FY8 X;  1DLS A;  4X5F A;  3K47 A;  3DAT A;  3RO9 A;  3EEK A;  3NZB X;  3SRW X;  1RX8 A;  3NZ9 X;  1PDB A;  2CD2 A;  1CD2 A;  1DG8 A;  3UM5 A;  5HF2 X;  4G95 A;  3SRS X;  1QZF A;  4HOE A;  3JW5 A;  2O7P A;  1DDS A;  1S3Y A;  1M7A A;  2LF1 A;  4TU5 X;  4ELH A;  4X5I A;  4CD2 A;  5DFR A;  4ELB A;  3D84 X;  5HF0 X;  2D0K A;  3ROA A;  1VDR A;  2DHF A;  3TQA A;  1RX2 A;  1DYR A;  1J3J A;  4KAK A;  3VCO A;  4M6K A;  4QLE A;  4KLX A;  4KNE A;  1DYI A;  3FQC A;  3FY9 X;  1IA4 A;  4X5G A;  3EEM A;  3DG8 A;  3S9U A;  4M2X A;  3NTZ A;  2AZN A;  3QYO A;  1KMS A;  2W9G A;  4LAH X;  1DG5 A;  1U72 A;  3NZA X;  3SAI A;  4KJL A;  3HJ3 A;  3FQ0 A;  4DPH A;  2BLC A;  2XW7 A;  5HVE A;  1AI9 A;  1BOZ A;  1DRF A;  1DIU A;  3F0U X;  4IXF X;  1LY4 A;  3KJS A;  3F8Z A;  3FRB X;  3FL9 A;  4EIG A;  4NX6 A;  1DHI A;  2GD9 A;  1J3I A;  2CIG A;  3F0Q X;  3TD8 A;  4FGG A;  1SEJ A;  4QLG A;  1RB2 A;  4QLF A;  2BL9 A;  1MVS A;  3GHV A;  3GYF A;  3JVX A;  1DRH A;  3QGT A;  3R33 A;  3D80 A;  5HPB A;  3DRC A;  3OCH A;  3KFY A;  5U26 A;  2JYB A;  1RX9 A;  1KLK A;  4KFJ A;  3KJR A;  4X5H A;  4FGH A;  1M78 A;  4Q67 A;  3SH2 A;  2W3M A;  2HM9 A;  2D5N A;  4KJJ A;  1RX1 A;  2FZH A;  3IA5 A;  3S3V A;  4XT5 A;  4HOG A;  2HXV A;  1RA8 A;  3QLZ A;  1U70 A;  2BLA A;  5HVB A;  3EX8 A;  1LY3 A;  3F0X X;  1U71 A;  1IA2 A;  4IXE D;  1OHK A;  2QK8 A;  4KL9 A;  2P4G A;  3CSE A;  3TQ8 A;  5CCC A;  3F91 A;  2W3B A;  3NZD A;  4LAE X;  4G8Z X;  1YHO A;  4I1N A;  1RH3 A;  4EIZ A;  5HI6 A;  1DRB A;  3CD2 A;  4HA9 A;  4NX7 A;  4DFR A;  3FYW X;  1IA1 A;  4KM2 A;  3EIG A;  1KMV A;  4PSY A;  4M7U A;  3FRD X;  3QLW A;  3QFX A;  3NRR A;  3UM8 A;  4EIL A;  2ANQ A;  1DAJ A;  4P3Q A;  5DXV A;  3FQV A;  1MVT A;  4IXG X;  3JW3 A;  1RA2 A;  4KYA A;  4XT8 A;  4Q6A A;  3IRM A;  3FQO A;  3KGY A;  3Q1H A;  3SA2 A;  2DRC A;  3SRR X;  2ANO A;  1AO8 A;  4DDR A;  4PSS A;  1RE7 A;  3IX9 A;  3I8A X;  1AOE A;  4P3R A;  2W3A A;  2W3V A;  3UM6 A;  3EEJ A;  4XE6 X;  2H2Q A;  1LUD A;  1TDR A;  1HFR A;  3QYL A;  2FZI A;  2OBC A;  3ZPC A;  4QJZ D;  4QJC A;  3DGA A;  4M6J A;  3LG4 A;  3JWF A;  3K74 A;  3FS6 A;  3S7A A;  3IRO A;  3M08 A;  3DAU A;  4PDJ A;  3FL8 A;  5FDA A;  4M6L A;  3QLX A;  4H97 A;  3SGY A;  4FHB A;  4EJ1 A;  4OSG A;  3F0S X;  1DR2 A;  4KY4 A;  1J3K A;  1RC4 A;  1OHJ A;  3DFR A;  3RG9 A;  3SRU X;  3K2H A;  2FZJ A;  4XT6 A;  4LAG X;  3QLS A;  4DP3 A;  1IA3 A;  3HBB A;  4PTJ A;  4QHV A;  4I13 A;  3FRE X;  5HSU A;  1DR5 A;  1RX3 A;  1VJ3 A;  3IA4 A;  1DR3 A;  3I3R A;  2C2T A;  1S3W A;  1DR6 A;  2W3W A;  3EEL A;  4P68 A;  1RG7 A;  1DIS A;  1DLR A;  4ELE A;  1RD7 A;  1RX5 A;  4HA7 A;  5HSR A;  3FYV X;  2W9H A;  3NXT A;  4XT7 A;  1DG7 A;  3L3R A;  2ZZA A;  4LEK X;  1DHJ A;  3INV A;  1DF7 A;  3SA1 A;  4GH8 A;  4KY8 A;  1DRE A;  4Q0D A;  3QLY A;  2W9S A;  3FQF A;  4ECK A;  7DFR A;  3QL3 A;  3FQZ A;  3K45 A;  1D1G A;  3NXX A;  1JUV A;  4XEC X;  5ECX A;  4DPD A;  1E26 A;  3GHC A;  1HFQ A;  3TQB A;  4H96 A;  1HFP A;  2KGK A;  4H98 A;  1DR4 A;  1DDR A;  4M7V A;  5E8Q A;  3KY8 A;  1RX7 A;  4XT4 A;  1DHF A;  1JOL A;  3JWC A;  3GI2 A;  4Q0E A;  3GHW A;  2INQ A;  4ELF A;  1DYJ A;  3N0H A;  5JG0 X;  3QG2 A;  1RF7 A;  4QI9 A;  3E0B A;  3IRN A;  2OIP A;  1DYH A;  5HQZ A;  1JOM A;  4G3M A;  4HOF A;  4PST A;  3SQY X;  1RB3 A;  3SRQ X;  1S3V A;  1RA1 A;  1M79 A;  3DL6 A;  3NXY A;  3SR5 X;  1BZF A;  3QLR A;  1RA9 A;  3M09 A;  5HT5 A;  5CC9 A;  3JWM A;  1DR7 A;  1ZDR A;  3ZPG A;  8DFR A;  3NXO A;  4ELG A;  3NXR A;  4X5J A;  1DRA A;  6DFR A;  3FRA X;  2BLB A;  5ECC A;  3QL0 A;  5U27 A;  3NZ6 X;  3OAF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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