3N0HA

Hdhfr double mutant q35s/n64f trimethoprim binary complex
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFSRMTTTSSVEGKQNLVIMGKKTWFSIPEKFRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 52
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2010-05-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3n0hA00
1DG5A 3FRFX 3NZ6X 1RA9A 3KJRA 3F0VX 3FQVA 3KGYA 3S3VA 4P68A 3NXYA 4QLEA 4IXED 4NX6A 1KLKA 3F0QX 4XT6A 4KFJA 1RE7A 3QFXA 3NZCX 3EEMA 2ZZAA 3RO9A 1RX7A 4HOGA 2CIGA 1OHJA 3FQZA 3EIGA 1HFQA 4XE6X 3DAUA 2L28A 2C2TA 3L3RA 4M6LA 4ELHA 3EEKA 3UM6A 4DFRA 4PSYA 1LUDA 4DPHA 4KJLA 5HT4A 2HQPA 2FZIA 4P3RA 1DREA 4TU5X 1DG7A 4QJZD 1M79A 3IRMA 3UM8A 3JWMA 3GHCA 3FYWX 1ZDRA 4HOEA 3JW5A 4Q0EA 3SRSX 3I8AX 1RG7A 1RX6A 5HI6A 5JG0X 5JA3A 1U71A 3NZAX 3KFYA 3K2HA 3NXXA 1JOMA 4Q6AA 1JOLA 1CD2A 3NXRA 3F0SX 4EJ1A 4KEBA 3NTZA 1RX8A 4KBNA 3JTWA 1BZFA 3EEJA 4KY8A 2P4GA 3JSUA 4OR7A 1J3IA 3OCHA 2OIPA 3K74A 3SRUX 1RX5A 4HA7A 3CL9A 3ZPGA 4LAEX 3GYFA 2XW7A 4PTHA 3GI2A 1S3WA 4DP3A 1U72A 3N0HA 1DHJA 1J3JA 3F0UX 4M7UA 3D80A 2OBCA 1RA2A 3TQ9A 3K47A 4CD2A 3IA4A 5EAJA 4QI9A 1DRHA 3JW3A 3DRCA 1DRBA 2BL9A 3GHWA 3QL3A 1DR6A 4PSTA 3INVA 4DPDA 1S3VA 4G3MA 3FQFA 3FL8A 4X5HA 2FZJA 3DG8A 1S3UA 1OHKA 3SA1A 3QLZA 2AZNA 4X5JA 4XT4A 3DGAA 1DG8A 4RGCA 3KY8A 1IA3A 2W3MA 4FHBA 4EIGA 4M7VA 3VCOA 2B3ZA 3TQAA 4EILA 2W9HA 4KJKA 4HA9A 4ELEA 4X5FA 2FZHA 2ITHA 3QL0A 4PTJA 5FDAA 2BLBA 2W3VA 3DFRA 2BLCA 4M6KA 4XT7A 1RB2A 4KJJA 1PDBA 3SAIA 3DL6A 3NXOA 3HBBA 4FGHA 3HJ3A 2W9SA 5HF0X 1E26A 1LY4A 1KMVA 1DRFA 3QG2A 4LAHX 1DHIA 3IX9A 3TQ8A 4I13A 1AO8A 4XT8A 1BOZA 1M78A 4M2XA 3F8ZA 2INQA 3FL9A 5CCCA 4XT5A 1DF7A 1HFPA 4P66A 3QYOA 1RX9A 3F0BX 3FRBX 3M09A 1DYJA 2HM9A 3M08A 4G95A 3UM5A 1RA3A 1DDRA 3JWKA 4LEKX 3R33A 3TQBA 1M7AA 1VDRA 1RA1A 4KYAA 3NU0A 3QLYA 1D1GA 4PDJA 4Q67A 4DDRA 4XECX 1DHFA 4QLFA 3LG4A 1U70A 3FQOA 3QLSA 4OSGA 2D5NA 3SH2A 1DDSA 3DATA 2BLAA 3Q1HA 4IXFX 3JWFA 1RX4A 2DHFA 5ECXA 4IXGX 3SRQX 2HXVA 5HF2X 2W9GA 1DLRA 4QHVA 3NZDA 1PD9A 1QZFA 3ROAA 4X5IA 4KLXA 4ECKA 5HSUA 4H98A 1RH3A 4ELBA 1KMSA 1DR7A 1RA8A 2KGKA 2JYBA 5HT5A 4X5GA 3NRRA 4KAKA 4NX7A 1DR1A 1MVSA 2ANQA 2H2QA 3DL5A 3F0XX 2C2SA 5HSRA 3ZPCA 3FRAX 1RD7A 3QLWA 3FREX 3JVXA 5U27A 3F91A 7DFRA 3NZ9X 5CC9A 3TD8A 4KNEA 5E8QA 3OAFA 5ECCA 3SR5X 1J3KA 3GHVA 1DRAA 2W9TA 4GH8A 5HQYA 2D0KA 4KL9A 1DISA 1AI9A 4M6JA 3K45A 2QK8A 2GD9A 4XRBA 3FYVX 2W3AA 1DYHA 1IA4A 4EIZA 2G6VA 3NZBX 5DFRA 4I1NA 1TDRA 1DR4A 3EX8A 4G8ZX 3QGTA 4H97A 4H95A 3CD2A 5HVEA 1DR5A 4PSSA 4P3QA 3FY9X 1DIUA 3CSEA 4Q0DA 3SRRX 2W3WA 3NXTA 4H96A 1YHOA 4LAGX 4KY4A 1RX3A 8DFRA 3IROA 3FQCA 3D84X 4ELFA 3RG9A 3QYLA 1IA2A 1S3YA 3CLBA 1RB3A 3FY8X 5DXVA 4ELGA 3S9UA 1JUVA 1RX2A 3SGYA 1RC4A 3S7AA 3SA2A 1DYRA 3I3RA 1RX1A 1DR3A 3FRDX 4KM2A 1IA1A 5HPBA 2LF1A 3F8YA 3QLXA 3NXVA 4QLGA 1AOEA 2ANOA 4KD7A 5HVBA 1DAJA 3JWCA 2DRCA 4HOFA 3E0BA 3KJSA 3SRWX 2O7PA 1SEJA 1DR2A 4FGGA 5HQZA 3EELA 5U26A 1CZ3A 1RF7A 1VJ3A 1PD8A 1DYIA 4QJCA 1HFRA 6DFRA 2W3BA 1MVTA 3FS6A 5HUIA 2CD2A 3SQYX 3QLRA 1LY3A 1DLSA 3FQ0A 3IRNA 4KM0A 3IA5A
chains in the Genus database with same CATH superfamily
1DG5A 3FRFX 3NZ6X 1RA9A 3KJRA 3F0VX 3FQVA 3KGYA 3S3VA 4P68A 3NXYA 4QLEA 4IXED 4NX6A 1KLKA 3F0QX 4XT6A 4KFJA 1RE7A 3QFXA 3NZCX 3EEMA 2ZZAA 3RO9A 1RX7A 4HOGA 2CIGA 1OHJA 3FQZA 3EIGA 1HFQA 4XE6X 3DAUA 2L28A 2C2TA 3L3RA 4M6LA 4ELHA 3EEKA 3UM6A 4DFRA 4PSYA 1LUDA 4DPHA 4KJLA 5HT4A 2HQPA 2FZIA 4P3RA 1DREA 4TU5X 1DG7A 4QJZD 1M79A 3IRMA 3UM8A 3JWMA 3GHCA 3FYWX 1ZDRA 4HOEA 3JW5A 4Q0EA 3SRSX 3I8AX 1RG7A 1RX6A 5HI6A 5JG0X 5JA3A 1U71A 3NZAX 3KFYA 3K2HA 3NXXA 1JOMA 4Q6AA 1JOLA 1CD2A 3NXRA 3F0SX 4EJ1A 4KEBA 3NTZA 1RX8A 4KBNA 3JTWA 1BZFA 3EEJA 4KY8A 2P4GA 3JSUA 4OR7A 1J3IA 3OCHA 2OIPA 3K74A 3SRUX 1RX5A 4HA7A 3CL9A 3ZPGA 4LAEX 3GYFA 2XW7A 4PTHA 3GI2A 1S3WA 4DP3A 1U72A 3N0HA 1DHJA 1J3JA 3F0UX 4M7UA 3D80A 2OBCA 1RA2A 3TQ9A 3K47A 4CD2A 3IA4A 5EAJA 4QI9A 1DRHA 3JW3A 3DRCA 1DRBA 2BL9A 3GHWA 3QL3A 1DR6A 4PSTA 3INVA 4DPDA 1S3VA 4G3MA 3FQFA 3FL8A 4X5HA 2FZJA 3DG8A 1S3UA 1OHKA 3SA1A 3QLZA 2AZNA 4X5JA 4XT4A 3DGAA 1DG8A 4RGCA 3KY8A 1IA3A 2W3MA 4FHBA 4EIGA 4M7VA 3VCOA 2B3ZA 3TQAA 4EILA 2W9HA 4KJKA 4HA9A 4ELEA 4X5FA 2FZHA 2ITHA 3QL0A 4PTJA 5FDAA 2BLBA 2W3VA 3DFRA 2BLCA 4M6KA 4XT7A 1RB2A 4KJJA 1PDBA 3SAIA 3DL6A 3NXOA 3HBBA 4FGHA 3HJ3A 2W9SA 5HF0X 1E26A 1LY4A 1KMVA 1DRFA 3QG2A 4LAHX 1DHIA 3IX9A 3TQ8A 4I13A 1AO8A 4XT8A 1BOZA 1M78A 4M2XA 3F8ZA 2INQA 3FL9A 5CCCA 4XT5A 1DF7A 1HFPA 4P66A 3QYOA 1RX9A 3F0BX 3FRBX 3M09A 1DYJA 2HM9A 3M08A 4G95A 3UM5A 1RA3A 1DDRA 3JWKA 4LEKX 3R33A 3TQBA 1M7AA 1VDRA 1RA1A 4KYAA 3NU0A 3QLYA 1D1GA 4PDJA 4Q67A 4DDRA 4XECX 1DHFA 4QLFA 3LG4A 1U70A 3FQOA 3QLSA 4OSGA 2D5NA 3SH2A 1DDSA 3DATA 2BLAA 3Q1HA 4IXFX 3JWFA 1RX4A 2DHFA 5ECXA 4IXGX 3SRQX 2HXVA 5HF2X 2W9GA 1DLRA 4QHVA 3NZDA 1PD9A 1QZFA 3ROAA 4X5IA 4KLXA 4ECKA 5HSUA 4H98A 1RH3A 4ELBA 1KMSA 1DR7A 1RA8A 2KGKA 2JYBA 5HT5A 4X5GA 3NRRA 4KAKA 4NX7A 1DR1A 1MVSA 2ANQA 2H2QA 3DL5A 3F0XX 2C2SA 5HSRA 3ZPCA 3FRAX 1RD7A 3QLWA 3FREX 3JVXA 5U27A 3F91A 7DFRA 3NZ9X 5CC9A 3TD8A 4KNEA 5E8QA 3OAFA 5ECCA 3SR5X 1J3KA 3GHVA 1DRAA 2W9TA 4GH8A 5HQYA 2D0KA 4KL9A 1DISA 1AI9A 4M6JA 3K45A 2QK8A 2GD9A 4XRBA 3FYVX 2W3AA 1DYHA 1IA4A 4EIZA 2G6VA 3NZBX 5DFRA 4I1NA 1TDRA 1DR4A 3EX8A 4G8ZX 3QGTA 4H97A 4H95A 3CD2A 5HVEA 1DR5A 4PSSA 4P3QA 3FY9X 1DIUA 3CSEA 4Q0DA 3SRRX 2W3WA 3NXTA 4H96A 1YHOA 4LAGX 4KY4A 1RX3A 8DFRA 3IROA 3FQCA 3D84X 4ELFA 3RG9A 3QYLA 1IA2A 1S3YA 3CLBA 1RB3A 3FY8X 5DXVA 4ELGA 3S9UA 1JUVA 1RX2A 3SGYA 1RC4A 3S7AA 3SA2A 1DYRA 3I3RA 1RX1A 1DR3A 3FRDX 4KM2A 1IA1A 5HPBA 2LF1A 3F8YA 3QLXA 3NXVA 4QLGA 1AOEA 2ANOA 4KD7A 5HVBA 1DAJA 3JWCA 2DRCA 4HOFA 3E0BA 3KJSA 3SRWX 2O7PA 1SEJA 1DR2A 4FGGA 5HQZA 3EELA 5U26A 1CZ3A 1RF7A 1VJ3A 1PD8A 1DYIA 4QJCA 1HFRA 6DFRA 2W3BA 1MVTA 3FS6A 5HUIA 2CD2A 3SQYX 3QLRA 1LY3A 1DLSA 3FQ0A 3IRNA 4KM0A 3IA5A
chains in the Genus database with same CATH topology
1DG5A 3FRFX 3NZ6X 1RA9A 3KJRA 3F0VX 3FQVA 3KGYA 3S3VA 4P68A 3NXYA 4QLEA 4IXED 4NX6A 1KLKA 3F0QX 4XT6A 4KFJA 1RE7A 3QFXA 3NZCX 3EEMA 2ZZAA 3RO9A 1RX7A 4HOGA 2CIGA 1OHJA 3FQZA 3EIGA 1HFQA 4XE6X 3DAUA 2L28A 2C2TA 3L3RA 4M6LA 4ELHA 3EEKA 3UM6A 4DFRA 4PSYA 1LUDA 4DPHA 4KJLA 5HT4A 2HQPA 2FZIA 4P3RA 1DREA 4TU5X 1DG7A 4QJZD 1M79A 3IRMA 3UM8A 3JWMA 3GHCA 3FYWX 1ZDRA 4HOEA 3JW5A 4Q0EA 3SRSX 3I8AX 1RG7A 1RX6A 5HI6A 5JG0X 5JA3A 1U71A 3NZAX 3KFYA 3K2HA 3NXXA 1JOMA 4Q6AA 1JOLA 1CD2A 3NXRA 3F0SX 4EJ1A 4KEBA 3NTZA 1RX8A 4KBNA 3JTWA 1BZFA 3EEJA 4KY8A 2P4GA 3JSUA 4OR7A 1J3IA 3OCHA 2OIPA 3K74A 3SRUX 1RX5A 4HA7A 3CL9A 3ZPGA 4LAEX 3GYFA 2XW7A 4PTHA 3GI2A 1S3WA 4DP3A 1U72A 3N0HA 1DHJA 1J3JA 3F0UX 4M7UA 3D80A 2OBCA 1RA2A 3TQ9A 3K47A 4CD2A 3IA4A 5EAJA 4QI9A 1DRHA 3JW3A 3DRCA 1DRBA 2BL9A 3GHWA 3QL3A 1DR6A 4PSTA 3INVA 4DPDA 1S3VA 4G3MA 3FQFA 3FL8A 4X5HA 2FZJA 3DG8A 1S3UA 1OHKA 3SA1A 3QLZA 2AZNA 4X5JA 4XT4A 3DGAA 1DG8A 4RGCA 3KY8A 1IA3A 2W3MA 4FHBA 4EIGA 4M7VA 3VCOA 2B3ZA 3TQAA 4EILA 2W9HA 4KJKA 4HA9A 4ELEA 4X5FA 2FZHA 2ITHA 3QL0A 4PTJA 5FDAA 2BLBA 2W3VA 3DFRA 2BLCA 4M6KA 4XT7A 1RB2A 4KJJA 1PDBA 3SAIA 3DL6A 3NXOA 3HBBA 4FGHA 3HJ3A 2W9SA 5HF0X 1E26A 1LY4A 1KMVA 1DRFA 3QG2A 4LAHX 1DHIA 3IX9A 3TQ8A 4I13A 1AO8A 4XT8A 1BOZA 1M78A 4M2XA 3F8ZA 2INQA 3FL9A 5CCCA 4XT5A 1DF7A 1HFPA 4P66A 3QYOA 1RX9A 3F0BX 3FRBX 3M09A 1DYJA 2HM9A 3M08A 4G95A 3UM5A 1RA3A 1DDRA 3JWKA 4LEKX 3R33A 3TQBA 1M7AA 1VDRA 1RA1A 4KYAA 3NU0A 3QLYA 1D1GA 4PDJA 4Q67A 4DDRA 4XECX 1DHFA 4QLFA 3LG4A 1U70A 3FQOA 3QLSA 4OSGA 2D5NA 3SH2A 1DDSA 3DATA 2BLAA 3Q1HA 4IXFX 3JWFA 1RX4A 2DHFA 5ECXA 4IXGX 3SRQX 2HXVA 5HF2X 2W9GA 1DLRA 4QHVA 3NZDA 1PD9A 1QZFA 3ROAA 4X5IA 4KLXA 4ECKA 5HSUA 4H98A 1RH3A 4ELBA 1KMSA 1DR7A 1RA8A 2KGKA 2JYBA 5HT5A 4X5GA 3NRRA 4KAKA 4NX7A 1DR1A 1MVSA 2ANQA 2H2QA 3DL5A 3F0XX 2C2SA 5HSRA 3ZPCA 3FRAX 1RD7A 3QLWA 3FREX 3JVXA 5U27A 3F91A 7DFRA 3NZ9X 5CC9A 3TD8A 4KNEA 5E8QA 3OAFA 5ECCA 3SR5X 1J3KA 3GHVA 1DRAA 2W9TA 4GH8A 5HQYA 2D0KA 4KL9A 1DISA 1AI9A 4M6JA 3K45A 2QK8A 2GD9A 4XRBA 3FYVX 2W3AA 1DYHA 1IA4A 4EIZA 2G6VA 3NZBX 5DFRA 4I1NA 1TDRA 1DR4A 3EX8A 4G8ZX 3QGTA 4H97A 4H95A 3CD2A 5HVEA 1DR5A 4PSSA 4P3QA 3FY9X 1DIUA 3CSEA 4Q0DA 3SRRX 2W3WA 3NXTA 4H96A 1YHOA 4LAGX 4KY4A 1RX3A 8DFRA 3IROA 3FQCA 3D84X 4ELFA 3RG9A 3QYLA 1IA2A 1S3YA 3CLBA 1RB3A 3FY8X 5DXVA 4ELGA 3S9UA 1JUVA 1RX2A 3SGYA 1RC4A 3S7AA 3SA2A 1DYRA 3I3RA 1RX1A 1DR3A 3FRDX 4KM2A 1IA1A 5HPBA 2LF1A 3F8YA 3QLXA 3NXVA 4QLGA 1AOEA 2ANOA 4KD7A 5HVBA 1DAJA 3JWCA 2DRCA 4HOFA 3E0BA 3KJSA 3SRWX 2O7PA 1SEJA 1DR2A 4FGGA 5HQZA 3EELA 5U26A 1CZ3A 1RF7A 1VJ3A 1PD8A 1DYIA 4QJCA 1HFRA 6DFRA 2W3BA 1MVTA 3FS6A 5HUIA 2CD2A 3SQYX 3QLRA 1LY3A 1DLSA 3FQ0A 3IRNA 4KM0A 3IA5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DG5 A;  3FRF X;  3NZ6 X;  1RA9 A;  3KJR A;  3F0V X;  3FQV A;  3KGY A;  3S3V A;  4P68 A;  3NXY A;  4QLE A;  4IXE D;  4NX6 A;  1KLK A;  3F0Q X;  4XT6 A;  4KFJ A;  1RE7 A;  3QFX A;  3NZC X;  3EEM A;  2ZZA A;  3RO9 A;  1RX7 A;  4HOG A;  2CIG A;  1OHJ A;  3FQZ A;  3EIG A;  1HFQ A;  4XE6 X;  3DAU A;  2L28 A;  2C2T A;  3L3R A;  4M6L A;  4ELH A;  3EEK A;  3UM6 A;  4DFR A;  4PSY A;  1LUD A;  4DPH A;  4KJL A;  5HT4 A;  2HQP A;  2FZI A;  4P3R A;  1DRE A;  4TU5 X;  1DG7 A;  4QJZ D;  1M79 A;  3IRM A;  3UM8 A;  3JWM A;  3GHC A;  3FYW X;  1ZDR A;  4HOE A;  3JW5 A;  4Q0E A;  3SRS X;  3I8A X;  1RG7 A;  1RX6 A;  5HI6 A;  5JG0 X;  5JA3 A;  1U71 A;  3NZA X;  3KFY A;  3K2H A;  3NXX A;  1JOM A;  4Q6A A;  1JOL A;  1CD2 A;  3NXR A;  3F0S X;  4EJ1 A;  4KEB A;  3NTZ A;  1RX8 A;  4KBN A;  3JTW A;  1BZF A;  3EEJ A;  4KY8 A;  2P4G A;  3JSU A;  4OR7 A;  1J3I A;  3OCH A;  2OIP A;  3K74 A;  3SRU X;  1RX5 A;  4HA7 A;  3CL9 A;  3ZPG A;  4LAE X;  3GYF A;  2XW7 A;  4PTH A;  3GI2 A;  1S3W A;  4DP3 A;  1U72 A;  3N0H A;  1DHJ A;  1J3J A;  3F0U X;  4M7U A;  3D80 A;  2OBC A;  1RA2 A;  3TQ9 A;  3K47 A;  4CD2 A;  3IA4 A;  5EAJ A;  4QI9 A;  1DRH A;  3JW3 A;  3DRC A;  1DRB A;  2BL9 A;  3GHW A;  3QL3 A;  1DR6 A;  4PST A;  3INV A;  4DPD A;  1S3V A;  4G3M A;  3FQF A;  3FL8 A;  4X5H A;  2FZJ A;  3DG8 A;  1S3U A;  1OHK A;  3SA1 A;  3QLZ A;  2AZN A;  4X5J A;  4XT4 A;  3DGA A;  1DG8 A;  4RGC A;  3KY8 A;  1IA3 A;  2W3M A;  4FHB A;  4EIG A;  4M7V A;  3VCO A;  2B3Z A;  3TQA A;  4EIL A;  2W9H A;  4KJK A;  4HA9 A;  4ELE A;  4X5F A;  2FZH A;  2ITH A;  3QL0 A;  4PTJ A;  5FDA A;  2BLB A;  2W3V A;  3DFR A;  2BLC A;  4M6K A;  4XT7 A;  1RB2 A;  4KJJ A;  1PDB A;  3SAI A;  3DL6 A;  3NXO A;  3HBB A;  4FGH A;  3HJ3 A;  2W9S A;  5HF0 X;  1E26 A;  1LY4 A;  1KMV A;  1DRF A;  3QG2 A;  4LAH X;  1DHI A;  3IX9 A;  3TQ8 A;  4I13 A;  1AO8 A;  4XT8 A;  1BOZ A;  1M78 A;  4M2X A;  3F8Z A;  2INQ A;  3FL9 A;  5CCC A;  4XT5 A;  1DF7 A;  1HFP A;  4P66 A;  3QYO A;  1RX9 A;  3F0B X;  3FRB X;  3M09 A;  1DYJ A;  2HM9 A;  3M08 A;  4G95 A;  3UM5 A;  1RA3 A;  1DDR A;  3JWK A;  4LEK X;  3R33 A;  3TQB A;  1M7A A;  1VDR A;  1RA1 A;  4KYA A;  3NU0 A;  3QLY A;  1D1G A;  4PDJ A;  4Q67 A;  4DDR A;  4XEC X;  1DHF A;  4QLF A;  3LG4 A;  1U70 A;  3FQO A;  3QLS A;  4OSG A;  2D5N A;  3SH2 A;  1DDS A;  3DAT A;  2BLA A;  3Q1H A;  4IXF X;  3JWF A;  1RX4 A;  2DHF A;  5ECX A;  4IXG X;  3SRQ X;  2HXV A;  5HF2 X;  2W9G A;  1DLR A;  4QHV A;  3NZD A;  1PD9 A;  1QZF A;  3ROA A;  4X5I A;  4KLX A;  4ECK A;  5HSU A;  4H98 A;  1RH3 A;  4ELB A;  1KMS A;  1DR7 A;  1RA8 A;  2KGK A;  2JYB A;  5HT5 A;  4X5G A;  3NRR A;  4KAK A;  4NX7 A;  1DR1 A;  1MVS A;  2ANQ A;  2H2Q A;  3DL5 A;  3F0X X;  2C2S A;  5HSR A;  3ZPC A;  3FRA X;  1RD7 A;  3QLW A;  3FRE X;  3JVX A;  5U27 A;  3F91 A;  7DFR A;  3NZ9 X;  5CC9 A;  3TD8 A;  4KNE A;  5E8Q A;  3OAF A;  5ECC A;  3SR5 X;  1J3K A;  3GHV A;  1DRA A;  2W9T A;  4GH8 A;  5HQY A;  2D0K A;  4KL9 A;  1DIS A;  1AI9 A;  4M6J A;  3K45 A;  2QK8 A;  2GD9 A;  4XRB A;  3FYV X;  2W3A A;  1DYH A;  1IA4 A;  4EIZ A;  2G6V A;  3NZB X;  5DFR A;  4I1N A;  1TDR A;  1DR4 A;  3EX8 A;  4G8Z X;  3QGT A;  4H97 A;  4H95 A;  3CD2 A;  5HVE A;  1DR5 A;  4PSS A;  4P3Q A;  3FY9 X;  1DIU A;  3CSE A;  4Q0D A;  3SRR X;  2W3W A;  3NXT A;  4H96 A;  1YHO A;  4LAG X;  4KY4 A;  1RX3 A;  8DFR A;  3IRO A;  3FQC A;  3D84 X;  4ELF A;  3RG9 A;  3QYL A;  1IA2 A;  1S3Y A;  3CLB A;  1RB3 A;  3FY8 X;  5DXV A;  4ELG A;  3S9U A;  1JUV A;  1RX2 A;  3SGY A;  1RC4 A;  3S7A A;  3SA2 A;  1DYR A;  3I3R A;  1RX1 A;  1DR3 A;  3FRD X;  4KM2 A;  1IA1 A;  5HPB A;  2LF1 A;  3F8Y A;  3QLX A;  3NXV A;  4QLG A;  1AOE A;  2ANO A;  4KD7 A;  5HVB A;  1DAJ A;  3JWC A;  2DRC A;  4HOF A;  3E0B A;  3KJS A;  3SRW X;  2O7P A;  1SEJ A;  1DR2 A;  4FGG A;  5HQZ A;  3EEL A;  5U26 A;  1CZ3 A;  1RF7 A;  1VJ3 A;  1PD8 A;  1DYI A;  4QJC A;  1HFR A;  6DFR A;  2W3B A;  1MVT A;  3FS6 A;  5HUI A;  2CD2 A;  3SQY X;  3QLR A;  1LY3 A;  1DLS A;  3FQ0 A;  3IRN A;  4KM0 A;  3IA5 A; 
#chains in the Genus database with same CATH topology
 1DG5 A;  3FRF X;  3NZ6 X;  1RA9 A;  3KJR A;  3F0V X;  3FQV A;  3KGY A;  3S3V A;  4P68 A;  3NXY A;  4QLE A;  4IXE D;  4NX6 A;  1KLK A;  3F0Q X;  4XT6 A;  4KFJ A;  1RE7 A;  3QFX A;  3NZC X;  3EEM A;  2ZZA A;  3RO9 A;  1RX7 A;  4HOG A;  2CIG A;  1OHJ A;  3FQZ A;  3EIG A;  1HFQ A;  4XE6 X;  3DAU A;  2L28 A;  2C2T A;  3L3R A;  4M6L A;  4ELH A;  3EEK A;  3UM6 A;  4DFR A;  4PSY A;  1LUD A;  4DPH A;  4KJL A;  5HT4 A;  2HQP A;  2FZI A;  4P3R A;  1DRE A;  4TU5 X;  1DG7 A;  4QJZ D;  1M79 A;  3IRM A;  3UM8 A;  3JWM A;  3GHC A;  3FYW X;  1ZDR A;  4HOE A;  3JW5 A;  4Q0E A;  3SRS X;  3I8A X;  1RG7 A;  1RX6 A;  5HI6 A;  5JG0 X;  5JA3 A;  1U71 A;  3NZA X;  3KFY A;  3K2H A;  3NXX A;  1JOM A;  4Q6A A;  1JOL A;  1CD2 A;  3NXR A;  3F0S X;  4EJ1 A;  4KEB A;  3NTZ A;  1RX8 A;  4KBN A;  3JTW A;  1BZF A;  3EEJ A;  4KY8 A;  2P4G A;  3JSU A;  4OR7 A;  1J3I A;  3OCH A;  2OIP A;  3K74 A;  3SRU X;  1RX5 A;  4HA7 A;  3CL9 A;  3ZPG A;  4LAE X;  3GYF A;  2XW7 A;  4PTH A;  3GI2 A;  1S3W A;  4DP3 A;  1U72 A;  3N0H A;  1DHJ A;  1J3J A;  3F0U X;  4M7U A;  3D80 A;  2OBC A;  1RA2 A;  3TQ9 A;  3K47 A;  4CD2 A;  3IA4 A;  5EAJ A;  4QI9 A;  1DRH A;  3JW3 A;  3DRC A;  1DRB A;  2BL9 A;  3GHW A;  3QL3 A;  1DR6 A;  4PST A;  3INV A;  4DPD A;  1S3V A;  4G3M A;  3FQF A;  3FL8 A;  4X5H A;  2FZJ A;  3DG8 A;  1S3U A;  1OHK A;  3SA1 A;  3QLZ A;  2AZN A;  4X5J A;  4XT4 A;  3DGA A;  1DG8 A;  4RGC A;  3KY8 A;  1IA3 A;  2W3M A;  4FHB A;  4EIG A;  4M7V A;  3VCO A;  2B3Z A;  3TQA A;  4EIL A;  2W9H A;  4KJK A;  4HA9 A;  4ELE A;  4X5F A;  2FZH A;  2ITH A;  3QL0 A;  4PTJ A;  5FDA A;  2BLB A;  2W3V A;  3DFR A;  2BLC A;  4M6K A;  4XT7 A;  1RB2 A;  4KJJ A;  1PDB A;  3SAI A;  3DL6 A;  3NXO A;  3HBB A;  4FGH A;  3HJ3 A;  2W9S A;  5HF0 X;  1E26 A;  1LY4 A;  1KMV A;  1DRF A;  3QG2 A;  4LAH X;  1DHI A;  3IX9 A;  3TQ8 A;  4I13 A;  1AO8 A;  4XT8 A;  1BOZ A;  1M78 A;  4M2X A;  3F8Z A;  2INQ A;  3FL9 A;  5CCC A;  4XT5 A;  1DF7 A;  1HFP A;  4P66 A;  3QYO A;  1RX9 A;  3F0B X;  3FRB X;  3M09 A;  1DYJ A;  2HM9 A;  3M08 A;  4G95 A;  3UM5 A;  1RA3 A;  1DDR A;  3JWK A;  4LEK X;  3R33 A;  3TQB A;  1M7A A;  1VDR A;  1RA1 A;  4KYA A;  3NU0 A;  3QLY A;  1D1G A;  4PDJ A;  4Q67 A;  4DDR A;  4XEC X;  1DHF A;  4QLF A;  3LG4 A;  1U70 A;  3FQO A;  3QLS A;  4OSG A;  2D5N A;  3SH2 A;  1DDS A;  3DAT A;  2BLA A;  3Q1H A;  4IXF X;  3JWF A;  1RX4 A;  2DHF A;  5ECX A;  4IXG X;  3SRQ X;  2HXV A;  5HF2 X;  2W9G A;  1DLR A;  4QHV A;  3NZD A;  1PD9 A;  1QZF A;  3ROA A;  4X5I A;  4KLX A;  4ECK A;  5HSU A;  4H98 A;  1RH3 A;  4ELB A;  1KMS A;  1DR7 A;  1RA8 A;  2KGK A;  2JYB A;  5HT5 A;  4X5G A;  3NRR A;  4KAK A;  4NX7 A;  1DR1 A;  1MVS A;  2ANQ A;  2H2Q A;  3DL5 A;  3F0X X;  2C2S A;  5HSR A;  3ZPC A;  3FRA X;  1RD7 A;  3QLW A;  3FRE X;  3JVX A;  5U27 A;  3F91 A;  7DFR A;  3NZ9 X;  5CC9 A;  3TD8 A;  4KNE A;  5E8Q A;  3OAF A;  5ECC A;  3SR5 X;  1J3K A;  3GHV A;  1DRA A;  2W9T A;  4GH8 A;  5HQY A;  2D0K A;  4KL9 A;  1DIS A;  1AI9 A;  4M6J A;  3K45 A;  2QK8 A;  2GD9 A;  4XRB A;  3FYV X;  2W3A A;  1DYH A;  1IA4 A;  4EIZ A;  2G6V A;  3NZB X;  5DFR A;  4I1N A;  1TDR A;  1DR4 A;  3EX8 A;  4G8Z X;  3QGT A;  4H97 A;  4H95 A;  3CD2 A;  5HVE A;  1DR5 A;  4PSS A;  4P3Q A;  3FY9 X;  1DIU A;  3CSE A;  4Q0D A;  3SRR X;  2W3W A;  3NXT A;  4H96 A;  1YHO A;  4LAG X;  4KY4 A;  1RX3 A;  8DFR A;  3IRO A;  3FQC A;  3D84 X;  4ELF A;  3RG9 A;  3QYL A;  1IA2 A;  1S3Y A;  3CLB A;  1RB3 A;  3FY8 X;  5DXV A;  4ELG A;  3S9U A;  1JUV A;  1RX2 A;  3SGY A;  1RC4 A;  3S7A A;  3SA2 A;  1DYR A;  3I3R A;  1RX1 A;  1DR3 A;  3FRD X;  4KM2 A;  1IA1 A;  5HPB A;  2LF1 A;  3F8Y A;  3QLX A;  3NXV A;  4QLG A;  1AOE A;  2ANO A;  4KD7 A;  5HVB A;  1DAJ A;  3JWC A;  2DRC A;  4HOF A;  3E0B A;  3KJS A;  3SRW X;  2O7P A;  1SEJ A;  1DR2 A;  4FGG A;  5HQZ A;  3EEL A;  5U26 A;  1CZ3 A;  1RF7 A;  1VJ3 A;  1PD8 A;  1DYI A;  4QJC A;  1HFR A;  6DFR A;  2W3B A;  1MVT A;  3FS6 A;  5HUI A;  2CD2 A;  3SQY X;  3QLR A;  1LY3 A;  1DLS A;  3FQ0 A;  3IRN A;  4KM0 A;  3IA5 A; 
#chains in the Genus database with same CATH homology
 1DG5 A;  3FRF X;  3NZ6 X;  1RA9 A;  3KJR A;  3F0V X;  3FQV A;  3KGY A;  3S3V A;  4P68 A;  3NXY A;  4QLE A;  4IXE D;  4NX6 A;  1KLK A;  3F0Q X;  4XT6 A;  4KFJ A;  1RE7 A;  3QFX A;  3NZC X;  3EEM A;  2ZZA A;  3RO9 A;  1RX7 A;  4HOG A;  2CIG A;  1OHJ A;  3FQZ A;  3EIG A;  1HFQ A;  4XE6 X;  3DAU A;  2L28 A;  2C2T A;  3L3R A;  4M6L A;  4ELH A;  3EEK A;  3UM6 A;  4DFR A;  4PSY A;  1LUD A;  4DPH A;  4KJL A;  5HT4 A;  2HQP A;  2FZI A;  4P3R A;  1DRE A;  4TU5 X;  1DG7 A;  4QJZ D;  1M79 A;  3IRM A;  3UM8 A;  3JWM A;  3GHC A;  3FYW X;  1ZDR A;  4HOE A;  3JW5 A;  4Q0E A;  3SRS X;  3I8A X;  1RG7 A;  1RX6 A;  5HI6 A;  5JG0 X;  5JA3 A;  1U71 A;  3NZA X;  3KFY A;  3K2H A;  3NXX A;  1JOM A;  4Q6A A;  1JOL A;  1CD2 A;  3NXR A;  3F0S X;  4EJ1 A;  4KEB A;  3NTZ A;  1RX8 A;  4KBN A;  3JTW A;  1BZF A;  3EEJ A;  4KY8 A;  2P4G A;  3JSU A;  4OR7 A;  1J3I A;  3OCH A;  2OIP A;  3K74 A;  3SRU X;  1RX5 A;  4HA7 A;  3CL9 A;  3ZPG A;  4LAE X;  3GYF A;  2XW7 A;  4PTH A;  3GI2 A;  1S3W A;  4DP3 A;  1U72 A;  3N0H A;  1DHJ A;  1J3J A;  3F0U X;  4M7U A;  3D80 A;  2OBC A;  1RA2 A;  3TQ9 A;  3K47 A;  4CD2 A;  3IA4 A;  5EAJ A;  4QI9 A;  1DRH A;  3JW3 A;  3DRC A;  1DRB A;  2BL9 A;  3GHW A;  3QL3 A;  1DR6 A;  4PST A;  3INV A;  4DPD A;  1S3V A;  4G3M A;  3FQF A;  3FL8 A;  4X5H A;  2FZJ A;  3DG8 A;  1S3U A;  1OHK A;  3SA1 A;  3QLZ A;  2AZN A;  4X5J A;  4XT4 A;  3DGA A;  1DG8 A;  4RGC A;  3KY8 A;  1IA3 A;  2W3M A;  4FHB A;  4EIG A;  4M7V A;  3VCO A;  2B3Z A;  3TQA A;  4EIL A;  2W9H A;  4KJK A;  4HA9 A;  4ELE A;  4X5F A;  2FZH A;  2ITH A;  3QL0 A;  4PTJ A;  5FDA A;  2BLB A;  2W3V A;  3DFR A;  2BLC A;  4M6K A;  4XT7 A;  1RB2 A;  4KJJ A;  1PDB A;  3SAI A;  3DL6 A;  3NXO A;  3HBB A;  4FGH A;  3HJ3 A;  2W9S A;  5HF0 X;  1E26 A;  1LY4 A;  1KMV A;  1DRF A;  3QG2 A;  4LAH X;  1DHI A;  3IX9 A;  3TQ8 A;  4I13 A;  1AO8 A;  4XT8 A;  1BOZ A;  1M78 A;  4M2X A;  3F8Z A;  2INQ A;  3FL9 A;  5CCC A;  4XT5 A;  1DF7 A;  1HFP A;  4P66 A;  3QYO A;  1RX9 A;  3F0B X;  3FRB X;  3M09 A;  1DYJ A;  2HM9 A;  3M08 A;  4G95 A;  3UM5 A;  1RA3 A;  1DDR A;  3JWK A;  4LEK X;  3R33 A;  3TQB A;  1M7A A;  1VDR A;  1RA1 A;  4KYA A;  3NU0 A;  3QLY A;  1D1G A;  4PDJ A;  4Q67 A;  4DDR A;  4XEC X;  1DHF A;  4QLF A;  3LG4 A;  1U70 A;  3FQO A;  3QLS A;  4OSG A;  2D5N A;  3SH2 A;  1DDS A;  3DAT A;  2BLA A;  3Q1H A;  4IXF X;  3JWF A;  1RX4 A;  2DHF A;  5ECX A;  4IXG X;  3SRQ X;  2HXV A;  5HF2 X;  2W9G A;  1DLR A;  4QHV A;  3NZD A;  1PD9 A;  1QZF A;  3ROA A;  4X5I A;  4KLX A;  4ECK A;  5HSU A;  4H98 A;  1RH3 A;  4ELB A;  1KMS A;  1DR7 A;  1RA8 A;  2KGK A;  2JYB A;  5HT5 A;  4X5G A;  3NRR A;  4KAK A;  4NX7 A;  1DR1 A;  1MVS A;  2ANQ A;  2H2Q A;  3DL5 A;  3F0X X;  2C2S A;  5HSR A;  3ZPC A;  3FRA X;  1RD7 A;  3QLW A;  3FRE X;  3JVX A;  5U27 A;  3F91 A;  7DFR A;  3NZ9 X;  5CC9 A;  3TD8 A;  4KNE A;  5E8Q A;  3OAF A;  5ECC A;  3SR5 X;  1J3K A;  3GHV A;  1DRA A;  2W9T A;  4GH8 A;  5HQY A;  2D0K A;  4KL9 A;  1DIS A;  1AI9 A;  4M6J A;  3K45 A;  2QK8 A;  2GD9 A;  4XRB A;  3FYV X;  2W3A A;  1DYH A;  1IA4 A;  4EIZ A;  2G6V A;  3NZB X;  5DFR A;  4I1N A;  1TDR A;  1DR4 A;  3EX8 A;  4G8Z X;  3QGT A;  4H97 A;  4H95 A;  3CD2 A;  5HVE A;  1DR5 A;  4PSS A;  4P3Q A;  3FY9 X;  1DIU A;  3CSE A;  4Q0D A;  3SRR X;  2W3W A;  3NXT A;  4H96 A;  1YHO A;  4LAG X;  4KY4 A;  1RX3 A;  8DFR A;  3IRO A;  3FQC A;  3D84 X;  4ELF A;  3RG9 A;  3QYL A;  1IA2 A;  1S3Y A;  3CLB A;  1RB3 A;  3FY8 X;  5DXV A;  4ELG A;  3S9U A;  1JUV A;  1RX2 A;  3SGY A;  1RC4 A;  3S7A A;  3SA2 A;  1DYR A;  3I3R A;  1RX1 A;  1DR3 A;  3FRD X;  4KM2 A;  1IA1 A;  5HPB A;  2LF1 A;  3F8Y A;  3QLX A;  3NXV A;  4QLG A;  1AOE A;  2ANO A;  4KD7 A;  5HVB A;  1DAJ A;  3JWC A;  2DRC A;  4HOF A;  3E0B A;  3KJS A;  3SRW X;  2O7P A;  1SEJ A;  1DR2 A;  4FGG A;  5HQZ A;  3EEL A;  5U26 A;  1CZ3 A;  1RF7 A;  1VJ3 A;  1PD8 A;  1DYI A;  4QJC A;  1HFR A;  6DFR A;  2W3B A;  1MVT A;  3FS6 A;  5HUI A;  2CD2 A;  3SQY X;  3QLR A;  1LY3 A;  1DLS A;  3FQ0 A;  3IRN A;  4KM0 A;  3IA5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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