3NXRA

Perferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 57
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2010-07-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3nxrA00
3SRSX 2P4GA 4KJJA 4H97A 4P3QA 1DHJA 1PD8A 1M78A 3K47A 4G95A 2L28A 3QL0A 1RF7A 3ZPGA 4TU5X 3EEJA 4XT6A 4X5JA 4KNEA 1KMVA 2OBCA 4Q67A 1J3KA 3IA4A 3KFYA 3FS6A 3EIGA 3QLXA 3OCHA 4XT4A 1LY4A 3N0HA 5U27A 4G3MA 1RX3A 4M6LA 4DFRA 3NXTA 1TDRA 2W9HA 1HFRA 1PD9A 1DR6A 3TQ9A 4ELHA 1IA4A 1KMSA 3Q1HA 1IA2A 3GYFA 3CLBA 5ECXA 1PDBA 2G6VA 3F0UX 3DL6A 3RO9A 4KY8A 1RG7A 4P68A 5FDAA 1RA3A 4IXFX 4LEKX 3M08A 7DFRA 4EIGA 4DPHA 5HSRA 3L3RA 4OR7A 3SGYA 5CC9A 3FYWX 1RX4A 3QLYA 3FQCA 3QYLA 5HT4A 3NXOA 1RA9A 3KJRA 3SA2A 3NXRA 1QZFA 3F8YA 1DR7A 5HVBA 3S7AA 5ECCA 2W9SA 5HF0X 4P66A 1DR3A 2FZJA 4HOFA 3FQ0A 3KGYA 1LY3A 1VJ3A 1M7AA 2BL9A 1KLKA 2INQA 1S3VA 4X5HA 2KGKA 1U72A 1RA1A 2ITHA 1DRBA 3IX9A 1S3UA 2D0KA 4ELBA 4KFJA 4KLXA 6DFRA 3DAUA 2DRCA 4PSSA 1DIUA 4Q6AA 3HJ3A 1YHOA 4FGGA 3ROAA 3GHVA 3FL8A 4Q0DA 2BLCA 4XE6X 2O7PA 2CIGA 3SR5X 5JG0X 4HA7A 1RD7A 5HI6A 3SRUX 4EIZA 4QLEA 4QJZD 3FRBX 1DHIA 5EAJA 1DAJA 4IXED 1S3WA 3K45A 1DYJA 2FZIA 1MVTA 4I13A 4M7UA 2W3MA 1DYIA 3SQYX 3JWCA 1S3YA 3NXXA 4ELEA 3QFXA 3CD2A 2W9TA 1CD2A 5HPBA 4M6JA 5HQYA 3K2HA 1HFPA 4KBNA 2W3VA 3VCOA 4OSGA 3SRQX 1RA8A 4X5FA 1M79A 3JVXA 1DRFA 3I3RA 1DHFA 3R33A 8DFRA 3F91A 3SRRX 4M7VA 1AO8A 1DYHA 3FQFA 3TQAA 2W9GA 4QLFA 2C2SA 3D84X 1DLRA 5HUIA 4P3RA 2QK8A 3NZCX 1DG5A 1RX1A 4PSTA 3F0XX 1DG8A 1RX6A 4NX6A 5HVEA 1RB2A 2CD2A 3ZPCA 2W3WA 4KJKA 3TD8A 4HOEA 5HT5A 1E26A 2DHFA 5CCCA 4XT7A 1LUDA 1BOZA 3FREX 4Q0EA 3NXVA 4KJLA 3FRAX 3EEMA 3KY8A 1RB3A 2ANOA 3FY9X 3F0BX 1OHJA 1DRAA 4DDRA 5DFRA 1DG7A 2HXVA 3K74A 1DR4A 3FQOA 3FRFX 4QJCA 3QLWA 1RX5A 4ELGA 1RH3A 3NU0A 2ZZAA 1BZFA 3JSUA 3DFRA 1D1GA 3SA1A 4LAEX 3GI2A 2W3BA 3IRNA 2D5NA 3HBBA 4KD7A 4IXGX 4PDJA 4RGCA 1JUVA 4NX7A 3FL9A 5E8QA 3E0BA 4H98A 3NZBX 1DREA 4DPDA 4FHBA 4XECX 3FQZA 1AOEA 4FGHA 3GHWA 4PTHA 3QG2A 3IA5A 3JWMA 1HFQA 4DP3A 3EELA 3DRCA 3D80A 1DDRA 2C2TA 3NZ9X 3QLZA 1JOMA 1MVSA 3CL9A 2BLAA 3S3VA 4QI9A 3F0QX 4EJ1A 1J3JA 4KAKA 1RA2A 3NZDA 2AZNA 3TQ8A 3FYVX 3LG4A 3QYOA 3JWFA 3F8ZA 4KM2A 1AI9A 3SRWX 2HQPA 3FRDX 1DISA 3SAIA 3UM5A 1IA3A 3EX8A 3IRMA 3JWKA 1DYRA 3CSEA 2LF1A 1IA1A 3JW5A 2HM9A 4QHVA 5DXVA 3RG9A 4H96A 2BLBA 3S9UA 3TQBA 3DL5A 1DF7A 4KY4A 4XRBA 4PTJA 2FZHA 2B3ZA 4HA9A 1DR2A 4CD2A 3DG8A 4KL9A 3F0VX 1DR5A 1CZ3A 5HF2X 4ELFA 1U71A 4GH8A 1OHKA 2XW7A 4EILA 3I8AX 3KJSA 3QLSA 3F0SX 3UM6A 1RX2A 1RC4A 1RX8A 3NZAX 2GD9A 3DATA 3M09A 1DRHA 1SEJA 3JTWA 5U26A 1JOLA 5HSUA 2H2QA 1VDRA 4G8ZX 3SH2A 3GHCA 1DLSA 3NRRA 4LAHX 2JYBA 1ZDRA 3FQVA 2W3AA 2OIPA 1RX7A 4QLGA 1DR1A 4PSYA 1RX9A 1DDSA 4X5IA 4KYAA 3IROA 3NXYA 4M6KA 5HQZA 4I1NA 4LAGX 5JA3A 4ECKA 1U70A 3UM8A 3FY8X 2ANQA 4XT5A 4M2XA 4KEBA 3NTZA 3DGAA 4HOGA 4XT8A 4X5GA 1J3IA 3QL3A 3OAFA 1RE7A 4H95A 3QGTA 4KM0A 3INVA 3JW3A 3EEKA 3NZ6X 3QLRA
chains in the Genus database with same CATH superfamily
3SRSX 2P4GA 4KJJA 4H97A 4P3QA 1DHJA 1PD8A 1M78A 3K47A 4G95A 2L28A 3QL0A 1RF7A 3ZPGA 4TU5X 3EEJA 4XT6A 4X5JA 4KNEA 1KMVA 2OBCA 4Q67A 1J3KA 3IA4A 3KFYA 3FS6A 3EIGA 3QLXA 3OCHA 4XT4A 1LY4A 3N0HA 5U27A 4G3MA 1RX3A 4M6LA 4DFRA 3NXTA 1TDRA 2W9HA 1HFRA 1PD9A 1DR6A 3TQ9A 4ELHA 1IA4A 1KMSA 3Q1HA 1IA2A 3GYFA 3CLBA 5ECXA 1PDBA 2G6VA 3F0UX 3DL6A 3RO9A 4KY8A 1RG7A 4P68A 5FDAA 1RA3A 4IXFX 4LEKX 3M08A 7DFRA 4EIGA 4DPHA 5HSRA 3L3RA 4OR7A 3SGYA 5CC9A 3FYWX 1RX4A 3QLYA 3FQCA 3QYLA 5HT4A 3NXOA 1RA9A 3KJRA 3SA2A 3NXRA 1QZFA 3F8YA 1DR7A 5HVBA 3S7AA 5ECCA 2W9SA 5HF0X 4P66A 1DR3A 2FZJA 4HOFA 3FQ0A 3KGYA 1LY3A 1VJ3A 1M7AA 2BL9A 1KLKA 2INQA 1S3VA 4X5HA 2KGKA 1U72A 1RA1A 2ITHA 1DRBA 3IX9A 1S3UA 2D0KA 4ELBA 4KFJA 4KLXA 6DFRA 3DAUA 2DRCA 4PSSA 1DIUA 4Q6AA 3HJ3A 1YHOA 4FGGA 3ROAA 3GHVA 3FL8A 4Q0DA 2BLCA 4XE6X 2O7PA 2CIGA 3SR5X 5JG0X 4HA7A 1RD7A 5HI6A 3SRUX 4EIZA 4QLEA 4QJZD 3FRBX 1DHIA 5EAJA 1DAJA 4IXED 1S3WA 3K45A 1DYJA 2FZIA 1MVTA 4I13A 4M7UA 2W3MA 1DYIA 3SQYX 3JWCA 1S3YA 3NXXA 4ELEA 3QFXA 3CD2A 2W9TA 1CD2A 5HPBA 4M6JA 5HQYA 3K2HA 1HFPA 4KBNA 2W3VA 3VCOA 4OSGA 3SRQX 1RA8A 4X5FA 1M79A 3JVXA 1DRFA 3I3RA 1DHFA 3R33A 8DFRA 3F91A 3SRRX 4M7VA 1AO8A 1DYHA 3FQFA 3TQAA 2W9GA 4QLFA 2C2SA 3D84X 1DLRA 5HUIA 4P3RA 2QK8A 3NZCX 1DG5A 1RX1A 4PSTA 3F0XX 1DG8A 1RX6A 4NX6A 5HVEA 1RB2A 2CD2A 3ZPCA 2W3WA 4KJKA 3TD8A 4HOEA 5HT5A 1E26A 2DHFA 5CCCA 4XT7A 1LUDA 1BOZA 3FREX 4Q0EA 3NXVA 4KJLA 3FRAX 3EEMA 3KY8A 1RB3A 2ANOA 3FY9X 3F0BX 1OHJA 1DRAA 4DDRA 5DFRA 1DG7A 2HXVA 3K74A 1DR4A 3FQOA 3FRFX 4QJCA 3QLWA 1RX5A 4ELGA 1RH3A 3NU0A 2ZZAA 1BZFA 3JSUA 3DFRA 1D1GA 3SA1A 4LAEX 3GI2A 2W3BA 3IRNA 2D5NA 3HBBA 4KD7A 4IXGX 4PDJA 4RGCA 1JUVA 4NX7A 3FL9A 5E8QA 3E0BA 4H98A 3NZBX 1DREA 4DPDA 4FHBA 4XECX 3FQZA 1AOEA 4FGHA 3GHWA 4PTHA 3QG2A 3IA5A 3JWMA 1HFQA 4DP3A 3EELA 3DRCA 3D80A 1DDRA 2C2TA 3NZ9X 3QLZA 1JOMA 1MVSA 3CL9A 2BLAA 3S3VA 4QI9A 3F0QX 4EJ1A 1J3JA 4KAKA 1RA2A 3NZDA 2AZNA 3TQ8A 3FYVX 3LG4A 3QYOA 3JWFA 3F8ZA 4KM2A 1AI9A 3SRWX 2HQPA 3FRDX 1DISA 3SAIA 3UM5A 1IA3A 3EX8A 3IRMA 3JWKA 1DYRA 3CSEA 2LF1A 1IA1A 3JW5A 2HM9A 4QHVA 5DXVA 3RG9A 4H96A 2BLBA 3S9UA 3TQBA 3DL5A 1DF7A 4KY4A 4XRBA 4PTJA 2FZHA 2B3ZA 4HA9A 1DR2A 4CD2A 3DG8A 4KL9A 3F0VX 1DR5A 1CZ3A 5HF2X 4ELFA 1U71A 4GH8A 1OHKA 2XW7A 4EILA 3I8AX 3KJSA 3QLSA 3F0SX 3UM6A 1RX2A 1RC4A 1RX8A 3NZAX 2GD9A 3DATA 3M09A 1DRHA 1SEJA 3JTWA 5U26A 1JOLA 5HSUA 2H2QA 1VDRA 4G8ZX 3SH2A 3GHCA 1DLSA 3NRRA 4LAHX 2JYBA 1ZDRA 3FQVA 2W3AA 2OIPA 1RX7A 4QLGA 1DR1A 4PSYA 1RX9A 1DDSA 4X5IA 4KYAA 3IROA 3NXYA 4M6KA 5HQZA 4I1NA 4LAGX 5JA3A 4ECKA 1U70A 3UM8A 3FY8X 2ANQA 4XT5A 4M2XA 4KEBA 3NTZA 3DGAA 4HOGA 4XT8A 4X5GA 1J3IA 3QL3A 3OAFA 1RE7A 4H95A 3QGTA 4KM0A 3INVA 3JW3A 3EEKA 3NZ6X 3QLRA
chains in the Genus database with same CATH topology
3SRSX 2P4GA 4KJJA 4H97A 4P3QA 1DHJA 1PD8A 1M78A 3K47A 4G95A 2L28A 3QL0A 1RF7A 3ZPGA 4TU5X 3EEJA 4XT6A 4X5JA 4KNEA 1KMVA 2OBCA 4Q67A 1J3KA 3IA4A 3KFYA 3FS6A 3EIGA 3QLXA 3OCHA 4XT4A 1LY4A 3N0HA 5U27A 4G3MA 1RX3A 4M6LA 4DFRA 3NXTA 1TDRA 2W9HA 1HFRA 1PD9A 1DR6A 3TQ9A 4ELHA 1IA4A 1KMSA 3Q1HA 1IA2A 3GYFA 3CLBA 5ECXA 1PDBA 2G6VA 3F0UX 3DL6A 3RO9A 4KY8A 1RG7A 4P68A 5FDAA 1RA3A 4IXFX 4LEKX 3M08A 7DFRA 4EIGA 4DPHA 5HSRA 3L3RA 4OR7A 3SGYA 5CC9A 3FYWX 1RX4A 3QLYA 3FQCA 3QYLA 5HT4A 3NXOA 1RA9A 3KJRA 3SA2A 3NXRA 1QZFA 3F8YA 1DR7A 5HVBA 3S7AA 5ECCA 2W9SA 5HF0X 4P66A 1DR3A 2FZJA 4HOFA 3FQ0A 3KGYA 1LY3A 1VJ3A 1M7AA 2BL9A 1KLKA 2INQA 1S3VA 4X5HA 2KGKA 1U72A 1RA1A 2ITHA 1DRBA 3IX9A 1S3UA 2D0KA 4ELBA 4KFJA 4KLXA 6DFRA 3DAUA 2DRCA 4PSSA 1DIUA 4Q6AA 3HJ3A 1YHOA 4FGGA 3ROAA 3GHVA 3FL8A 4Q0DA 2BLCA 4XE6X 2O7PA 2CIGA 3SR5X 5JG0X 4HA7A 1RD7A 5HI6A 3SRUX 4EIZA 4QLEA 4QJZD 3FRBX 1DHIA 5EAJA 1DAJA 4IXED 1S3WA 3K45A 1DYJA 2FZIA 1MVTA 4I13A 4M7UA 2W3MA 1DYIA 3SQYX 3JWCA 1S3YA 3NXXA 4ELEA 3QFXA 3CD2A 2W9TA 1CD2A 5HPBA 4M6JA 5HQYA 3K2HA 1HFPA 4KBNA 2W3VA 3VCOA 4OSGA 3SRQX 1RA8A 4X5FA 1M79A 3JVXA 1DRFA 3I3RA 1DHFA 3R33A 8DFRA 3F91A 3SRRX 4M7VA 1AO8A 1DYHA 3FQFA 3TQAA 2W9GA 4QLFA 2C2SA 3D84X 1DLRA 5HUIA 4P3RA 2QK8A 3NZCX 1DG5A 1RX1A 4PSTA 3F0XX 1DG8A 1RX6A 4NX6A 5HVEA 1RB2A 2CD2A 3ZPCA 2W3WA 4KJKA 3TD8A 4HOEA 5HT5A 1E26A 2DHFA 5CCCA 4XT7A 1LUDA 1BOZA 3FREX 4Q0EA 3NXVA 4KJLA 3FRAX 3EEMA 3KY8A 1RB3A 2ANOA 3FY9X 3F0BX 1OHJA 1DRAA 4DDRA 5DFRA 1DG7A 2HXVA 3K74A 1DR4A 3FQOA 3FRFX 4QJCA 3QLWA 1RX5A 4ELGA 1RH3A 3NU0A 2ZZAA 1BZFA 3JSUA 3DFRA 1D1GA 3SA1A 4LAEX 3GI2A 2W3BA 3IRNA 2D5NA 3HBBA 4KD7A 4IXGX 4PDJA 4RGCA 1JUVA 4NX7A 3FL9A 5E8QA 3E0BA 4H98A 3NZBX 1DREA 4DPDA 4FHBA 4XECX 3FQZA 1AOEA 4FGHA 3GHWA 4PTHA 3QG2A 3IA5A 3JWMA 1HFQA 4DP3A 3EELA 3DRCA 3D80A 1DDRA 2C2TA 3NZ9X 3QLZA 1JOMA 1MVSA 3CL9A 2BLAA 3S3VA 4QI9A 3F0QX 4EJ1A 1J3JA 4KAKA 1RA2A 3NZDA 2AZNA 3TQ8A 3FYVX 3LG4A 3QYOA 3JWFA 3F8ZA 4KM2A 1AI9A 3SRWX 2HQPA 3FRDX 1DISA 3SAIA 3UM5A 1IA3A 3EX8A 3IRMA 3JWKA 1DYRA 3CSEA 2LF1A 1IA1A 3JW5A 2HM9A 4QHVA 5DXVA 3RG9A 4H96A 2BLBA 3S9UA 3TQBA 3DL5A 1DF7A 4KY4A 4XRBA 4PTJA 2FZHA 2B3ZA 4HA9A 1DR2A 4CD2A 3DG8A 4KL9A 3F0VX 1DR5A 1CZ3A 5HF2X 4ELFA 1U71A 4GH8A 1OHKA 2XW7A 4EILA 3I8AX 3KJSA 3QLSA 3F0SX 3UM6A 1RX2A 1RC4A 1RX8A 3NZAX 2GD9A 3DATA 3M09A 1DRHA 1SEJA 3JTWA 5U26A 1JOLA 5HSUA 2H2QA 1VDRA 4G8ZX 3SH2A 3GHCA 1DLSA 3NRRA 4LAHX 2JYBA 1ZDRA 3FQVA 2W3AA 2OIPA 1RX7A 4QLGA 1DR1A 4PSYA 1RX9A 1DDSA 4X5IA 4KYAA 3IROA 3NXYA 4M6KA 5HQZA 4I1NA 4LAGX 5JA3A 4ECKA 1U70A 3UM8A 3FY8X 2ANQA 4XT5A 4M2XA 4KEBA 3NTZA 3DGAA 4HOGA 4XT8A 4X5GA 1J3IA 3QL3A 3OAFA 1RE7A 4H95A 3QGTA 4KM0A 3INVA 3JW3A 3EEKA 3NZ6X 3QLRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SRS X;  2P4G A;  4KJJ A;  4H97 A;  4P3Q A;  1DHJ A;  1PD8 A;  1M78 A;  3K47 A;  4G95 A;  2L28 A;  3QL0 A;  1RF7 A;  3ZPG A;  4TU5 X;  3EEJ A;  4XT6 A;  4X5J A;  4KNE A;  1KMV A;  2OBC A;  4Q67 A;  1J3K A;  3IA4 A;  3KFY A;  3FS6 A;  3EIG A;  3QLX A;  3OCH A;  4XT4 A;  1LY4 A;  3N0H A;  5U27 A;  4G3M A;  1RX3 A;  4M6L A;  4DFR A;  3NXT A;  1TDR A;  2W9H A;  1HFR A;  1PD9 A;  1DR6 A;  3TQ9 A;  4ELH A;  1IA4 A;  1KMS A;  3Q1H A;  1IA2 A;  3GYF A;  3CLB A;  5ECX A;  1PDB A;  2G6V A;  3F0U X;  3DL6 A;  3RO9 A;  4KY8 A;  1RG7 A;  4P68 A;  5FDA A;  1RA3 A;  4IXF X;  4LEK X;  3M08 A;  7DFR A;  4EIG A;  4DPH A;  5HSR A;  3L3R A;  4OR7 A;  3SGY A;  5CC9 A;  3FYW X;  1RX4 A;  3QLY A;  3FQC A;  3QYL A;  5HT4 A;  3NXO A;  1RA9 A;  3KJR A;  3SA2 A;  3NXR A;  1QZF A;  3F8Y A;  1DR7 A;  5HVB A;  3S7A A;  5ECC A;  2W9S A;  5HF0 X;  4P66 A;  1DR3 A;  2FZJ A;  4HOF A;  3FQ0 A;  3KGY A;  1LY3 A;  1VJ3 A;  1M7A A;  2BL9 A;  1KLK A;  2INQ A;  1S3V A;  4X5H A;  2KGK A;  1U72 A;  1RA1 A;  2ITH A;  1DRB A;  3IX9 A;  1S3U A;  2D0K A;  4ELB A;  4KFJ A;  4KLX A;  6DFR A;  3DAU A;  2DRC A;  4PSS A;  1DIU A;  4Q6A A;  3HJ3 A;  1YHO A;  4FGG A;  3ROA A;  3GHV A;  3FL8 A;  4Q0D A;  2BLC A;  4XE6 X;  2O7P A;  2CIG A;  3SR5 X;  5JG0 X;  4HA7 A;  1RD7 A;  5HI6 A;  3SRU X;  4EIZ A;  4QLE A;  4QJZ D;  3FRB X;  1DHI A;  5EAJ A;  1DAJ A;  4IXE D;  1S3W A;  3K45 A;  1DYJ A;  2FZI A;  1MVT A;  4I13 A;  4M7U A;  2W3M A;  1DYI A;  3SQY X;  3JWC A;  1S3Y A;  3NXX A;  4ELE A;  3QFX A;  3CD2 A;  2W9T A;  1CD2 A;  5HPB A;  4M6J A;  5HQY A;  3K2H A;  1HFP A;  4KBN A;  2W3V A;  3VCO A;  4OSG A;  3SRQ X;  1RA8 A;  4X5F A;  1M79 A;  3JVX A;  1DRF A;  3I3R A;  1DHF A;  3R33 A;  8DFR A;  3F91 A;  3SRR X;  4M7V A;  1AO8 A;  1DYH A;  3FQF A;  3TQA A;  2W9G A;  4QLF A;  2C2S A;  3D84 X;  1DLR A;  5HUI A;  4P3R A;  2QK8 A;  3NZC X;  1DG5 A;  1RX1 A;  4PST A;  3F0X X;  1DG8 A;  1RX6 A;  4NX6 A;  5HVE A;  1RB2 A;  2CD2 A;  3ZPC A;  2W3W A;  4KJK A;  3TD8 A;  4HOE A;  5HT5 A;  1E26 A;  2DHF A;  5CCC A;  4XT7 A;  1LUD A;  1BOZ A;  3FRE X;  4Q0E A;  3NXV A;  4KJL A;  3FRA X;  3EEM A;  3KY8 A;  1RB3 A;  2ANO A;  3FY9 X;  3F0B X;  1OHJ A;  1DRA A;  4DDR A;  5DFR A;  1DG7 A;  2HXV A;  3K74 A;  1DR4 A;  3FQO A;  3FRF X;  4QJC A;  3QLW A;  1RX5 A;  4ELG A;  1RH3 A;  3NU0 A;  2ZZA A;  1BZF A;  3JSU A;  3DFR A;  1D1G A;  3SA1 A;  4LAE X;  3GI2 A;  2W3B A;  3IRN A;  2D5N A;  3HBB A;  4KD7 A;  4IXG X;  4PDJ A;  4RGC A;  1JUV A;  4NX7 A;  3FL9 A;  5E8Q A;  3E0B A;  4H98 A;  3NZB X;  1DRE A;  4DPD A;  4FHB A;  4XEC X;  3FQZ A;  1AOE A;  4FGH A;  3GHW A;  4PTH A;  3QG2 A;  3IA5 A;  3JWM A;  1HFQ A;  4DP3 A;  3EEL A;  3DRC A;  3D80 A;  1DDR A;  2C2T A;  3NZ9 X;  3QLZ A;  1JOM A;  1MVS A;  3CL9 A;  2BLA A;  3S3V A;  4QI9 A;  3F0Q X;  4EJ1 A;  1J3J A;  4KAK A;  1RA2 A;  3NZD A;  2AZN A;  3TQ8 A;  3FYV X;  3LG4 A;  3QYO A;  3JWF A;  3F8Z A;  4KM2 A;  1AI9 A;  3SRW X;  2HQP A;  3FRD X;  1DIS A;  3SAI A;  3UM5 A;  1IA3 A;  3EX8 A;  3IRM A;  3JWK A;  1DYR A;  3CSE A;  2LF1 A;  1IA1 A;  3JW5 A;  2HM9 A;  4QHV A;  5DXV A;  3RG9 A;  4H96 A;  2BLB A;  3S9U A;  3TQB A;  3DL5 A;  1DF7 A;  4KY4 A;  4XRB A;  4PTJ A;  2FZH A;  2B3Z A;  4HA9 A;  1DR2 A;  4CD2 A;  3DG8 A;  4KL9 A;  3F0V X;  1DR5 A;  1CZ3 A;  5HF2 X;  4ELF A;  1U71 A;  4GH8 A;  1OHK A;  2XW7 A;  4EIL A;  3I8A X;  3KJS A;  3QLS A;  3F0S X;  3UM6 A;  1RX2 A;  1RC4 A;  1RX8 A;  3NZA X;  2GD9 A;  3DAT A;  3M09 A;  1DRH A;  1SEJ A;  3JTW A;  5U26 A;  1JOL A;  5HSU A;  2H2Q A;  1VDR A;  4G8Z X;  3SH2 A;  3GHC A;  1DLS A;  3NRR A;  4LAH X;  2JYB A;  1ZDR A;  3FQV A;  2W3A A;  2OIP A;  1RX7 A;  4QLG A;  1DR1 A;  4PSY A;  1RX9 A;  1DDS A;  4X5I A;  4KYA A;  3IRO A;  3NXY A;  4M6K A;  5HQZ A;  4I1N A;  4LAG X;  5JA3 A;  4ECK A;  1U70 A;  3UM8 A;  3FY8 X;  2ANQ A;  4XT5 A;  4M2X A;  4KEB A;  3NTZ A;  3DGA A;  4HOG A;  4XT8 A;  4X5G A;  1J3I A;  3QL3 A;  3OAF A;  1RE7 A;  4H95 A;  3QGT A;  4KM0 A;  3INV A;  3JW3 A;  3EEK A;  3NZ6 X;  3QLR A; 
#chains in the Genus database with same CATH topology
 3SRS X;  2P4G A;  4KJJ A;  4H97 A;  4P3Q A;  1DHJ A;  1PD8 A;  1M78 A;  3K47 A;  4G95 A;  2L28 A;  3QL0 A;  1RF7 A;  3ZPG A;  4TU5 X;  3EEJ A;  4XT6 A;  4X5J A;  4KNE A;  1KMV A;  2OBC A;  4Q67 A;  1J3K A;  3IA4 A;  3KFY A;  3FS6 A;  3EIG A;  3QLX A;  3OCH A;  4XT4 A;  1LY4 A;  3N0H A;  5U27 A;  4G3M A;  1RX3 A;  4M6L A;  4DFR A;  3NXT A;  1TDR A;  2W9H A;  1HFR A;  1PD9 A;  1DR6 A;  3TQ9 A;  4ELH A;  1IA4 A;  1KMS A;  3Q1H A;  1IA2 A;  3GYF A;  3CLB A;  5ECX A;  1PDB A;  2G6V A;  3F0U X;  3DL6 A;  3RO9 A;  4KY8 A;  1RG7 A;  4P68 A;  5FDA A;  1RA3 A;  4IXF X;  4LEK X;  3M08 A;  7DFR A;  4EIG A;  4DPH A;  5HSR A;  3L3R A;  4OR7 A;  3SGY A;  5CC9 A;  3FYW X;  1RX4 A;  3QLY A;  3FQC A;  3QYL A;  5HT4 A;  3NXO A;  1RA9 A;  3KJR A;  3SA2 A;  3NXR A;  1QZF A;  3F8Y A;  1DR7 A;  5HVB A;  3S7A A;  5ECC A;  2W9S A;  5HF0 X;  4P66 A;  1DR3 A;  2FZJ A;  4HOF A;  3FQ0 A;  3KGY A;  1LY3 A;  1VJ3 A;  1M7A A;  2BL9 A;  1KLK A;  2INQ A;  1S3V A;  4X5H A;  2KGK A;  1U72 A;  1RA1 A;  2ITH A;  1DRB A;  3IX9 A;  1S3U A;  2D0K A;  4ELB A;  4KFJ A;  4KLX A;  6DFR A;  3DAU A;  2DRC A;  4PSS A;  1DIU A;  4Q6A A;  3HJ3 A;  1YHO A;  4FGG A;  3ROA A;  3GHV A;  3FL8 A;  4Q0D A;  2BLC A;  4XE6 X;  2O7P A;  2CIG A;  3SR5 X;  5JG0 X;  4HA7 A;  1RD7 A;  5HI6 A;  3SRU X;  4EIZ A;  4QLE A;  4QJZ D;  3FRB X;  1DHI A;  5EAJ A;  1DAJ A;  4IXE D;  1S3W A;  3K45 A;  1DYJ A;  2FZI A;  1MVT A;  4I13 A;  4M7U A;  2W3M A;  1DYI A;  3SQY X;  3JWC A;  1S3Y A;  3NXX A;  4ELE A;  3QFX A;  3CD2 A;  2W9T A;  1CD2 A;  5HPB A;  4M6J A;  5HQY A;  3K2H A;  1HFP A;  4KBN A;  2W3V A;  3VCO A;  4OSG A;  3SRQ X;  1RA8 A;  4X5F A;  1M79 A;  3JVX A;  1DRF A;  3I3R A;  1DHF A;  3R33 A;  8DFR A;  3F91 A;  3SRR X;  4M7V A;  1AO8 A;  1DYH A;  3FQF A;  3TQA A;  2W9G A;  4QLF A;  2C2S A;  3D84 X;  1DLR A;  5HUI A;  4P3R A;  2QK8 A;  3NZC X;  1DG5 A;  1RX1 A;  4PST A;  3F0X X;  1DG8 A;  1RX6 A;  4NX6 A;  5HVE A;  1RB2 A;  2CD2 A;  3ZPC A;  2W3W A;  4KJK A;  3TD8 A;  4HOE A;  5HT5 A;  1E26 A;  2DHF A;  5CCC A;  4XT7 A;  1LUD A;  1BOZ A;  3FRE X;  4Q0E A;  3NXV A;  4KJL A;  3FRA X;  3EEM A;  3KY8 A;  1RB3 A;  2ANO A;  3FY9 X;  3F0B X;  1OHJ A;  1DRA A;  4DDR A;  5DFR A;  1DG7 A;  2HXV A;  3K74 A;  1DR4 A;  3FQO A;  3FRF X;  4QJC A;  3QLW A;  1RX5 A;  4ELG A;  1RH3 A;  3NU0 A;  2ZZA A;  1BZF A;  3JSU A;  3DFR A;  1D1G A;  3SA1 A;  4LAE X;  3GI2 A;  2W3B A;  3IRN A;  2D5N A;  3HBB A;  4KD7 A;  4IXG X;  4PDJ A;  4RGC A;  1JUV A;  4NX7 A;  3FL9 A;  5E8Q A;  3E0B A;  4H98 A;  3NZB X;  1DRE A;  4DPD A;  4FHB A;  4XEC X;  3FQZ A;  1AOE A;  4FGH A;  3GHW A;  4PTH A;  3QG2 A;  3IA5 A;  3JWM A;  1HFQ A;  4DP3 A;  3EEL A;  3DRC A;  3D80 A;  1DDR A;  2C2T A;  3NZ9 X;  3QLZ A;  1JOM A;  1MVS A;  3CL9 A;  2BLA A;  3S3V A;  4QI9 A;  3F0Q X;  4EJ1 A;  1J3J A;  4KAK A;  1RA2 A;  3NZD A;  2AZN A;  3TQ8 A;  3FYV X;  3LG4 A;  3QYO A;  3JWF A;  3F8Z A;  4KM2 A;  1AI9 A;  3SRW X;  2HQP A;  3FRD X;  1DIS A;  3SAI A;  3UM5 A;  1IA3 A;  3EX8 A;  3IRM A;  3JWK A;  1DYR A;  3CSE A;  2LF1 A;  1IA1 A;  3JW5 A;  2HM9 A;  4QHV A;  5DXV A;  3RG9 A;  4H96 A;  2BLB A;  3S9U A;  3TQB A;  3DL5 A;  1DF7 A;  4KY4 A;  4XRB A;  4PTJ A;  2FZH A;  2B3Z A;  4HA9 A;  1DR2 A;  4CD2 A;  3DG8 A;  4KL9 A;  3F0V X;  1DR5 A;  1CZ3 A;  5HF2 X;  4ELF A;  1U71 A;  4GH8 A;  1OHK A;  2XW7 A;  4EIL A;  3I8A X;  3KJS A;  3QLS A;  3F0S X;  3UM6 A;  1RX2 A;  1RC4 A;  1RX8 A;  3NZA X;  2GD9 A;  3DAT A;  3M09 A;  1DRH A;  1SEJ A;  3JTW A;  5U26 A;  1JOL A;  5HSU A;  2H2Q A;  1VDR A;  4G8Z X;  3SH2 A;  3GHC A;  1DLS A;  3NRR A;  4LAH X;  2JYB A;  1ZDR A;  3FQV A;  2W3A A;  2OIP A;  1RX7 A;  4QLG A;  1DR1 A;  4PSY A;  1RX9 A;  1DDS A;  4X5I A;  4KYA A;  3IRO A;  3NXY A;  4M6K A;  5HQZ A;  4I1N A;  4LAG X;  5JA3 A;  4ECK A;  1U70 A;  3UM8 A;  3FY8 X;  2ANQ A;  4XT5 A;  4M2X A;  4KEB A;  3NTZ A;  3DGA A;  4HOG A;  4XT8 A;  4X5G A;  1J3I A;  3QL3 A;  3OAF A;  1RE7 A;  4H95 A;  3QGT A;  4KM0 A;  3INV A;  3JW3 A;  3EEK A;  3NZ6 X;  3QLR A; 
#chains in the Genus database with same CATH homology
 3SRS X;  2P4G A;  4KJJ A;  4H97 A;  4P3Q A;  1DHJ A;  1PD8 A;  1M78 A;  3K47 A;  4G95 A;  2L28 A;  3QL0 A;  1RF7 A;  3ZPG A;  4TU5 X;  3EEJ A;  4XT6 A;  4X5J A;  4KNE A;  1KMV A;  2OBC A;  4Q67 A;  1J3K A;  3IA4 A;  3KFY A;  3FS6 A;  3EIG A;  3QLX A;  3OCH A;  4XT4 A;  1LY4 A;  3N0H A;  5U27 A;  4G3M A;  1RX3 A;  4M6L A;  4DFR A;  3NXT A;  1TDR A;  2W9H A;  1HFR A;  1PD9 A;  1DR6 A;  3TQ9 A;  4ELH A;  1IA4 A;  1KMS A;  3Q1H A;  1IA2 A;  3GYF A;  3CLB A;  5ECX A;  1PDB A;  2G6V A;  3F0U X;  3DL6 A;  3RO9 A;  4KY8 A;  1RG7 A;  4P68 A;  5FDA A;  1RA3 A;  4IXF X;  4LEK X;  3M08 A;  7DFR A;  4EIG A;  4DPH A;  5HSR A;  3L3R A;  4OR7 A;  3SGY A;  5CC9 A;  3FYW X;  1RX4 A;  3QLY A;  3FQC A;  3QYL A;  5HT4 A;  3NXO A;  1RA9 A;  3KJR A;  3SA2 A;  3NXR A;  1QZF A;  3F8Y A;  1DR7 A;  5HVB A;  3S7A A;  5ECC A;  2W9S A;  5HF0 X;  4P66 A;  1DR3 A;  2FZJ A;  4HOF A;  3FQ0 A;  3KGY A;  1LY3 A;  1VJ3 A;  1M7A A;  2BL9 A;  1KLK A;  2INQ A;  1S3V A;  4X5H A;  2KGK A;  1U72 A;  1RA1 A;  2ITH A;  1DRB A;  3IX9 A;  1S3U A;  2D0K A;  4ELB A;  4KFJ A;  4KLX A;  6DFR A;  3DAU A;  2DRC A;  4PSS A;  1DIU A;  4Q6A A;  3HJ3 A;  1YHO A;  4FGG A;  3ROA A;  3GHV A;  3FL8 A;  4Q0D A;  2BLC A;  4XE6 X;  2O7P A;  2CIG A;  3SR5 X;  5JG0 X;  4HA7 A;  1RD7 A;  5HI6 A;  3SRU X;  4EIZ A;  4QLE A;  4QJZ D;  3FRB X;  1DHI A;  5EAJ A;  1DAJ A;  4IXE D;  1S3W A;  3K45 A;  1DYJ A;  2FZI A;  1MVT A;  4I13 A;  4M7U A;  2W3M A;  1DYI A;  3SQY X;  3JWC A;  1S3Y A;  3NXX A;  4ELE A;  3QFX A;  3CD2 A;  2W9T A;  1CD2 A;  5HPB A;  4M6J A;  5HQY A;  3K2H A;  1HFP A;  4KBN A;  2W3V A;  3VCO A;  4OSG A;  3SRQ X;  1RA8 A;  4X5F A;  1M79 A;  3JVX A;  1DRF A;  3I3R A;  1DHF A;  3R33 A;  8DFR A;  3F91 A;  3SRR X;  4M7V A;  1AO8 A;  1DYH A;  3FQF A;  3TQA A;  2W9G A;  4QLF A;  2C2S A;  3D84 X;  1DLR A;  5HUI A;  4P3R A;  2QK8 A;  3NZC X;  1DG5 A;  1RX1 A;  4PST A;  3F0X X;  1DG8 A;  1RX6 A;  4NX6 A;  5HVE A;  1RB2 A;  2CD2 A;  3ZPC A;  2W3W A;  4KJK A;  3TD8 A;  4HOE A;  5HT5 A;  1E26 A;  2DHF A;  5CCC A;  4XT7 A;  1LUD A;  1BOZ A;  3FRE X;  4Q0E A;  3NXV A;  4KJL A;  3FRA X;  3EEM A;  3KY8 A;  1RB3 A;  2ANO A;  3FY9 X;  3F0B X;  1OHJ A;  1DRA A;  4DDR A;  5DFR A;  1DG7 A;  2HXV A;  3K74 A;  1DR4 A;  3FQO A;  3FRF X;  4QJC A;  3QLW A;  1RX5 A;  4ELG A;  1RH3 A;  3NU0 A;  2ZZA A;  1BZF A;  3JSU A;  3DFR A;  1D1G A;  3SA1 A;  4LAE X;  3GI2 A;  2W3B A;  3IRN A;  2D5N A;  3HBB A;  4KD7 A;  4IXG X;  4PDJ A;  4RGC A;  1JUV A;  4NX7 A;  3FL9 A;  5E8Q A;  3E0B A;  4H98 A;  3NZB X;  1DRE A;  4DPD A;  4FHB A;  4XEC X;  3FQZ A;  1AOE A;  4FGH A;  3GHW A;  4PTH A;  3QG2 A;  3IA5 A;  3JWM A;  1HFQ A;  4DP3 A;  3EEL A;  3DRC A;  3D80 A;  1DDR A;  2C2T A;  3NZ9 X;  3QLZ A;  1JOM A;  1MVS A;  3CL9 A;  2BLA A;  3S3V A;  4QI9 A;  3F0Q X;  4EJ1 A;  1J3J A;  4KAK A;  1RA2 A;  3NZD A;  2AZN A;  3TQ8 A;  3FYV X;  3LG4 A;  3QYO A;  3JWF A;  3F8Z A;  4KM2 A;  1AI9 A;  3SRW X;  2HQP A;  3FRD X;  1DIS A;  3SAI A;  3UM5 A;  1IA3 A;  3EX8 A;  3IRM A;  3JWK A;  1DYR A;  3CSE A;  2LF1 A;  1IA1 A;  3JW5 A;  2HM9 A;  4QHV A;  5DXV A;  3RG9 A;  4H96 A;  2BLB A;  3S9U A;  3TQB A;  3DL5 A;  1DF7 A;  4KY4 A;  4XRB A;  4PTJ A;  2FZH A;  2B3Z A;  4HA9 A;  1DR2 A;  4CD2 A;  3DG8 A;  4KL9 A;  3F0V X;  1DR5 A;  1CZ3 A;  5HF2 X;  4ELF A;  1U71 A;  4GH8 A;  1OHK A;  2XW7 A;  4EIL A;  3I8A X;  3KJS A;  3QLS A;  3F0S X;  3UM6 A;  1RX2 A;  1RC4 A;  1RX8 A;  3NZA X;  2GD9 A;  3DAT A;  3M09 A;  1DRH A;  1SEJ A;  3JTW A;  5U26 A;  1JOL A;  5HSU A;  2H2Q A;  1VDR A;  4G8Z X;  3SH2 A;  3GHC A;  1DLS A;  3NRR A;  4LAH X;  2JYB A;  1ZDR A;  3FQV A;  2W3A A;  2OIP A;  1RX7 A;  4QLG A;  1DR1 A;  4PSY A;  1RX9 A;  1DDS A;  4X5I A;  4KYA A;  3IRO A;  3NXY A;  4M6K A;  5HQZ A;  4I1N A;  4LAG X;  5JA3 A;  4ECK A;  1U70 A;  3UM8 A;  3FY8 X;  2ANQ A;  4XT5 A;  4M2X A;  4KEB A;  3NTZ A;  3DGA A;  4HOG A;  4XT8 A;  4X5G A;  1J3I A;  3QL3 A;  3OAF A;  1RE7 A;  4H95 A;  3QGT A;  4KM0 A;  3INV A;  3JW3 A;  3EEK A;  3NZ6 X;  3QLR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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