3NXVA

Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 57
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2010-07-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3nxvA00
2W3WA 3NXXA 4QJCA 4I1NA 4KEBA 4XT4A 1DRHA 3FRDX 3QYOA 3E0BA 2L28A 4PSSA 4X5HA 3DL5A 4QLEA 1DHJA 4H96A 4ELHA 1HFPA 3K45A 1RX2A 4G3MA 2BLCA 4DPHA 3F0VX 3JW5A 3DGAA 3DG8A 3F8ZA 3FYWX 3QFXA 3QLXA 3SH2A 3JWMA 3NXOA 3KJRA 5HSRA 3CLBA 1CD2A 3NZ6X 3D84X 2ITHA 1RX5A 2GD9A 3M08A 1VDRA 3FRAX 1DR6A 1RX3A 3GHWA 5DFRA 3JWFA 1QZFA 4FGGA 4KLXA 3EEKA 1DHFA 4EILA 4QJZD 2XW7A 1DDRA 4QHVA 1PD9A 5HVEA 1IA3A 1RX8A 3NZ9X 1RX4A 3JWKA 4X5GA 1RB3A 1HFRA 1RE7A 1RX9A 3SRUX 4DPDA 4KBNA 1LY4A 5DXVA 4EIZA 3QLYA 4LAGX 1BOZA 3OCHA 4M7VA 2ANOA 2C2TA 2W3MA 5CCCA 1DR3A 3EELA 2AZNA 3F0QX 2ANQA 1J3IA 4FHBA 4DP3A 3DATA 3FS6A 3Q1HA 5HF2X 4XT6A 3KFYA 1E26A 1JOMA 1JUVA 1MVSA 3FQOA 3QG2A 1RB2A 5HUIA 4KJLA 3FREX 1JOLA 2W9SA 1OHKA 1RA8A 4M6KA 5HPBA 3DAUA 1SEJA 4KY4A 4DFRA 1DIUA 3DRCA 1J3KA 4HOGA 2HQPA 3SAIA 1DG5A 3M09A 4KY8A 5HQYA 4M6LA 3QL0A 2INQA 1RX7A 3NRRA 2W9TA 3S3VA 4PSYA 3FYVX 4ECKA 4XT5A 4Q0EA 2O7PA 3R33A 3SRSX 3GHVA 4KJJA 2W3AA 4ELBA 3NZDA 1DR7A 3NZBX 5CC9A 4XRBA 3NXVA 3DFRA 3SRWX 3SA2A 5ECCA 5JA3A 3UM6A 2OBCA 3SGYA 2C2SA 4PTHA 3RO9A 2W3VA 3IX9A 3OAFA 1D1GA 3JVXA 3QLSA 1RX1A 2W9GA 4X5JA 3FRFX 3FQZA 4P68A 1DR5A 1KMVA 4EJ1A 3UM8A 3HBBA 1KLKA 3EIGA 1YHOA 3VCOA 3IRMA 3LG4A 4OR7A 3NU0A 3GI2A 4KFJA 5U26A 4LAEX 2FZJA 3EEJA 1ZDRA 3NXRA 2G6VA 1DLSA 2BLAA 4OSGA 4EIGA 1RX6A 4H98A 4KL9A 2D0KA 3F0SX 3QGTA 5ECXA 3UM5A 4KJKA 1S3WA 3K2HA 4QLFA 4KYAA 4RGCA 4XE6X 5HT4A 5FDAA 2HXVA 3FY9X 1DR2A 3N0HA 3S9UA 3IA4A 2QK8A 1DRAA 4PDJA 5JG0X 5HI6A 3CL9A 4IXED 3HJ3A 5HF0X 2BL9A 4P3RA 3TQAA 3QLZA 2H2QA 2W3BA 2FZHA 4M2XA 4Q67A 3IRNA 3DL6A 3NZAX 1RD7A 1DYHA 2KGKA 3K74A 3KGYA 4CD2A 3FQVA 4P3QA 4NX7A 4IXFX 3EEMA 3GHCA 4FGHA 3QLRA 1AI9A 4TU5X 1DR4A 4H95A 1M79A 1DR1A 1DG8A 3QYLA 3JSUA 1TDRA 4LEKX 3CD2A 4PTJA 3I3RA 1IA2A 4HOFA 1DDSA 3SA1A 8DFRA 4XECX 4HA9A 2CD2A 4G95A 1IA4A 1M7AA 4H97A 1HFQA 3I8AX 1PD8A 6DFRA 3F0UX 1DYJA 5HSUA 4HOEA 2LF1A 5U27A 3NZCX 5E8QA 3NTZA 4P66A 4KM0A 1DLRA 1RC4A 4DDRA 3SQYX 3EX8A 5HQZA 1OHJA 4QI9A 1DREA 5EAJA 4ELFA 1RF7A 1U72A 4G8ZX 3F8YA 1DISA 3FQFA 4ELGA 4KM2A 1BZFA 2HM9A 3SRQX 2DRCA 3KY8A 2P4GA 2D5NA 2DHFA 1PDBA 4NX6A 2ZZAA 1LY3A 3FRBX 1RH3A 4LAHX 1DYRA 1DG7A 1U70A 1J3JA 1DYIA 3K47A 2B3ZA 5HVBA 3D80A 3F0XX 4PSTA 3FQ0A 3TD8A 3NXYA 3IROA 4KD7A 4XT7A 1MVTA 3RG9A 3ZPCA 3FQCA 4GH8A 4IXGX 1U71A 3F0BX 4M7UA 1AOEA 1S3VA 3TQ9A 3SRRX 2BLBA 3JW3A 4QLGA 3TQBA 1DHIA 3ZPGA 3ROAA 1DRBA 4KAKA 1RA1A 1CZ3A 3F91A 3TQ8A 3SR5X 2OIPA 4M6JA 1AO8A 1DRFA 1RG7A 3FL9A 3S7AA 1RA9A 3CSEA 1M78A 3FL8A 3FY8X 1LUDA 4X5FA 3JTWA 4Q0DA 1KMSA 3QL3A 3IA5A 2W9HA 1IA1A 3NXTA 3QLWA 2CIGA 3INVA 1DAJA 4HA7A 1RA3A 4Q6AA 5HT5A 7DFRA 1S3YA 1VJ3A 1RA2A 1DF7A 3GYFA 3L3RA 4I13A 4ELEA 2FZIA 1S3UA 4KNEA 3JWCA 4X5IA 2JYBA 3KJSA 4XT8A
chains in the Genus database with same CATH superfamily
2W3WA 3NXXA 4QJCA 4I1NA 4KEBA 4XT4A 1DRHA 3FRDX 3QYOA 3E0BA 2L28A 4PSSA 4X5HA 3DL5A 4QLEA 1DHJA 4H96A 4ELHA 1HFPA 3K45A 1RX2A 4G3MA 2BLCA 4DPHA 3F0VX 3JW5A 3DGAA 3DG8A 3F8ZA 3FYWX 3QFXA 3QLXA 3SH2A 3JWMA 3NXOA 3KJRA 5HSRA 3CLBA 1CD2A 3NZ6X 3D84X 2ITHA 1RX5A 2GD9A 3M08A 1VDRA 3FRAX 1DR6A 1RX3A 3GHWA 5DFRA 3JWFA 1QZFA 4FGGA 4KLXA 3EEKA 1DHFA 4EILA 4QJZD 2XW7A 1DDRA 4QHVA 1PD9A 5HVEA 1IA3A 1RX8A 3NZ9X 1RX4A 3JWKA 4X5GA 1RB3A 1HFRA 1RE7A 1RX9A 3SRUX 4DPDA 4KBNA 1LY4A 5DXVA 4EIZA 3QLYA 4LAGX 1BOZA 3OCHA 4M7VA 2ANOA 2C2TA 2W3MA 5CCCA 1DR3A 3EELA 2AZNA 3F0QX 2ANQA 1J3IA 4FHBA 4DP3A 3DATA 3FS6A 3Q1HA 5HF2X 4XT6A 3KFYA 1E26A 1JOMA 1JUVA 1MVSA 3FQOA 3QG2A 1RB2A 5HUIA 4KJLA 3FREX 1JOLA 2W9SA 1OHKA 1RA8A 4M6KA 5HPBA 3DAUA 1SEJA 4KY4A 4DFRA 1DIUA 3DRCA 1J3KA 4HOGA 2HQPA 3SAIA 1DG5A 3M09A 4KY8A 5HQYA 4M6LA 3QL0A 2INQA 1RX7A 3NRRA 2W9TA 3S3VA 4PSYA 3FYVX 4ECKA 4XT5A 4Q0EA 2O7PA 3R33A 3SRSX 3GHVA 4KJJA 2W3AA 4ELBA 3NZDA 1DR7A 3NZBX 5CC9A 4XRBA 3NXVA 3DFRA 3SRWX 3SA2A 5ECCA 5JA3A 3UM6A 2OBCA 3SGYA 2C2SA 4PTHA 3RO9A 2W3VA 3IX9A 3OAFA 1D1GA 3JVXA 3QLSA 1RX1A 2W9GA 4X5JA 3FRFX 3FQZA 4P68A 1DR5A 1KMVA 4EJ1A 3UM8A 3HBBA 1KLKA 3EIGA 1YHOA 3VCOA 3IRMA 3LG4A 4OR7A 3NU0A 3GI2A 4KFJA 5U26A 4LAEX 2FZJA 3EEJA 1ZDRA 3NXRA 2G6VA 1DLSA 2BLAA 4OSGA 4EIGA 1RX6A 4H98A 4KL9A 2D0KA 3F0SX 3QGTA 5ECXA 3UM5A 4KJKA 1S3WA 3K2HA 4QLFA 4KYAA 4RGCA 4XE6X 5HT4A 5FDAA 2HXVA 3FY9X 1DR2A 3N0HA 3S9UA 3IA4A 2QK8A 1DRAA 4PDJA 5JG0X 5HI6A 3CL9A 4IXED 3HJ3A 5HF0X 2BL9A 4P3RA 3TQAA 3QLZA 2H2QA 2W3BA 2FZHA 4M2XA 4Q67A 3IRNA 3DL6A 3NZAX 1RD7A 1DYHA 2KGKA 3K74A 3KGYA 4CD2A 3FQVA 4P3QA 4NX7A 4IXFX 3EEMA 3GHCA 4FGHA 3QLRA 1AI9A 4TU5X 1DR4A 4H95A 1M79A 1DR1A 1DG8A 3QYLA 3JSUA 1TDRA 4LEKX 3CD2A 4PTJA 3I3RA 1IA2A 4HOFA 1DDSA 3SA1A 8DFRA 4XECX 4HA9A 2CD2A 4G95A 1IA4A 1M7AA 4H97A 1HFQA 3I8AX 1PD8A 6DFRA 3F0UX 1DYJA 5HSUA 4HOEA 2LF1A 5U27A 3NZCX 5E8QA 3NTZA 4P66A 4KM0A 1DLRA 1RC4A 4DDRA 3SQYX 3EX8A 5HQZA 1OHJA 4QI9A 1DREA 5EAJA 4ELFA 1RF7A 1U72A 4G8ZX 3F8YA 1DISA 3FQFA 4ELGA 4KM2A 1BZFA 2HM9A 3SRQX 2DRCA 3KY8A 2P4GA 2D5NA 2DHFA 1PDBA 4NX6A 2ZZAA 1LY3A 3FRBX 1RH3A 4LAHX 1DYRA 1DG7A 1U70A 1J3JA 1DYIA 3K47A 2B3ZA 5HVBA 3D80A 3F0XX 4PSTA 3FQ0A 3TD8A 3NXYA 3IROA 4KD7A 4XT7A 1MVTA 3RG9A 3ZPCA 3FQCA 4GH8A 4IXGX 1U71A 3F0BX 4M7UA 1AOEA 1S3VA 3TQ9A 3SRRX 2BLBA 3JW3A 4QLGA 3TQBA 1DHIA 3ZPGA 3ROAA 1DRBA 4KAKA 1RA1A 1CZ3A 3F91A 3TQ8A 3SR5X 2OIPA 4M6JA 1AO8A 1DRFA 1RG7A 3FL9A 3S7AA 1RA9A 3CSEA 1M78A 3FL8A 3FY8X 1LUDA 4X5FA 3JTWA 4Q0DA 1KMSA 3QL3A 3IA5A 2W9HA 1IA1A 3NXTA 3QLWA 2CIGA 3INVA 1DAJA 4HA7A 1RA3A 4Q6AA 5HT5A 7DFRA 1S3YA 1VJ3A 1RA2A 1DF7A 3GYFA 3L3RA 4I13A 4ELEA 2FZIA 1S3UA 4KNEA 3JWCA 4X5IA 2JYBA 3KJSA 4XT8A
chains in the Genus database with same CATH topology
2W3WA 3NXXA 4QJCA 4I1NA 4KEBA 4XT4A 1DRHA 3FRDX 3QYOA 3E0BA 2L28A 4PSSA 4X5HA 3DL5A 4QLEA 1DHJA 4H96A 4ELHA 1HFPA 3K45A 1RX2A 4G3MA 2BLCA 4DPHA 3F0VX 3JW5A 3DGAA 3DG8A 3F8ZA 3FYWX 3QFXA 3QLXA 3SH2A 3JWMA 3NXOA 3KJRA 5HSRA 3CLBA 1CD2A 3NZ6X 3D84X 2ITHA 1RX5A 2GD9A 3M08A 1VDRA 3FRAX 1DR6A 1RX3A 3GHWA 5DFRA 3JWFA 1QZFA 4FGGA 4KLXA 3EEKA 1DHFA 4EILA 4QJZD 2XW7A 1DDRA 4QHVA 1PD9A 5HVEA 1IA3A 1RX8A 3NZ9X 1RX4A 3JWKA 4X5GA 1RB3A 1HFRA 1RE7A 1RX9A 3SRUX 4DPDA 4KBNA 1LY4A 5DXVA 4EIZA 3QLYA 4LAGX 1BOZA 3OCHA 4M7VA 2ANOA 2C2TA 2W3MA 5CCCA 1DR3A 3EELA 2AZNA 3F0QX 2ANQA 1J3IA 4FHBA 4DP3A 3DATA 3FS6A 3Q1HA 5HF2X 4XT6A 3KFYA 1E26A 1JOMA 1JUVA 1MVSA 3FQOA 3QG2A 1RB2A 5HUIA 4KJLA 3FREX 1JOLA 2W9SA 1OHKA 1RA8A 4M6KA 5HPBA 3DAUA 1SEJA 4KY4A 4DFRA 1DIUA 3DRCA 1J3KA 4HOGA 2HQPA 3SAIA 1DG5A 3M09A 4KY8A 5HQYA 4M6LA 3QL0A 2INQA 1RX7A 3NRRA 2W9TA 3S3VA 4PSYA 3FYVX 4ECKA 4XT5A 4Q0EA 2O7PA 3R33A 3SRSX 3GHVA 4KJJA 2W3AA 4ELBA 3NZDA 1DR7A 3NZBX 5CC9A 4XRBA 3NXVA 3DFRA 3SRWX 3SA2A 5ECCA 5JA3A 3UM6A 2OBCA 3SGYA 2C2SA 4PTHA 3RO9A 2W3VA 3IX9A 3OAFA 1D1GA 3JVXA 3QLSA 1RX1A 2W9GA 4X5JA 3FRFX 3FQZA 4P68A 1DR5A 1KMVA 4EJ1A 3UM8A 3HBBA 1KLKA 3EIGA 1YHOA 3VCOA 3IRMA 3LG4A 4OR7A 3NU0A 3GI2A 4KFJA 5U26A 4LAEX 2FZJA 3EEJA 1ZDRA 3NXRA 2G6VA 1DLSA 2BLAA 4OSGA 4EIGA 1RX6A 4H98A 4KL9A 2D0KA 3F0SX 3QGTA 5ECXA 3UM5A 4KJKA 1S3WA 3K2HA 4QLFA 4KYAA 4RGCA 4XE6X 5HT4A 5FDAA 2HXVA 3FY9X 1DR2A 3N0HA 3S9UA 3IA4A 2QK8A 1DRAA 4PDJA 5JG0X 5HI6A 3CL9A 4IXED 3HJ3A 5HF0X 2BL9A 4P3RA 3TQAA 3QLZA 2H2QA 2W3BA 2FZHA 4M2XA 4Q67A 3IRNA 3DL6A 3NZAX 1RD7A 1DYHA 2KGKA 3K74A 3KGYA 4CD2A 3FQVA 4P3QA 4NX7A 4IXFX 3EEMA 3GHCA 4FGHA 3QLRA 1AI9A 4TU5X 1DR4A 4H95A 1M79A 1DR1A 1DG8A 3QYLA 3JSUA 1TDRA 4LEKX 3CD2A 4PTJA 3I3RA 1IA2A 4HOFA 1DDSA 3SA1A 8DFRA 4XECX 4HA9A 2CD2A 4G95A 1IA4A 1M7AA 4H97A 1HFQA 3I8AX 1PD8A 6DFRA 3F0UX 1DYJA 5HSUA 4HOEA 2LF1A 5U27A 3NZCX 5E8QA 3NTZA 4P66A 4KM0A 1DLRA 1RC4A 4DDRA 3SQYX 3EX8A 5HQZA 1OHJA 4QI9A 1DREA 5EAJA 4ELFA 1RF7A 1U72A 4G8ZX 3F8YA 1DISA 3FQFA 4ELGA 4KM2A 1BZFA 2HM9A 3SRQX 2DRCA 3KY8A 2P4GA 2D5NA 2DHFA 1PDBA 4NX6A 2ZZAA 1LY3A 3FRBX 1RH3A 4LAHX 1DYRA 1DG7A 1U70A 1J3JA 1DYIA 3K47A 2B3ZA 5HVBA 3D80A 3F0XX 4PSTA 3FQ0A 3TD8A 3NXYA 3IROA 4KD7A 4XT7A 1MVTA 3RG9A 3ZPCA 3FQCA 4GH8A 4IXGX 1U71A 3F0BX 4M7UA 1AOEA 1S3VA 3TQ9A 3SRRX 2BLBA 3JW3A 4QLGA 3TQBA 1DHIA 3ZPGA 3ROAA 1DRBA 4KAKA 1RA1A 1CZ3A 3F91A 3TQ8A 3SR5X 2OIPA 4M6JA 1AO8A 1DRFA 1RG7A 3FL9A 3S7AA 1RA9A 3CSEA 1M78A 3FL8A 3FY8X 1LUDA 4X5FA 3JTWA 4Q0DA 1KMSA 3QL3A 3IA5A 2W9HA 1IA1A 3NXTA 3QLWA 2CIGA 3INVA 1DAJA 4HA7A 1RA3A 4Q6AA 5HT5A 7DFRA 1S3YA 1VJ3A 1RA2A 1DF7A 3GYFA 3L3RA 4I13A 4ELEA 2FZIA 1S3UA 4KNEA 3JWCA 4X5IA 2JYBA 3KJSA 4XT8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W3W A;  3NXX A;  4QJC A;  4I1N A;  4KEB A;  4XT4 A;  1DRH A;  3FRD X;  3QYO A;  3E0B A;  2L28 A;  4PSS A;  4X5H A;  3DL5 A;  4QLE A;  1DHJ A;  4H96 A;  4ELH A;  1HFP A;  3K45 A;  1RX2 A;  4G3M A;  2BLC A;  4DPH A;  3F0V X;  3JW5 A;  3DGA A;  3DG8 A;  3F8Z A;  3FYW X;  3QFX A;  3QLX A;  3SH2 A;  3JWM A;  3NXO A;  3KJR A;  5HSR A;  3CLB A;  1CD2 A;  3NZ6 X;  3D84 X;  2ITH A;  1RX5 A;  2GD9 A;  3M08 A;  1VDR A;  3FRA X;  1DR6 A;  1RX3 A;  3GHW A;  5DFR A;  3JWF A;  1QZF A;  4FGG A;  4KLX A;  3EEK A;  1DHF A;  4EIL A;  4QJZ D;  2XW7 A;  1DDR A;  4QHV A;  1PD9 A;  5HVE A;  1IA3 A;  1RX8 A;  3NZ9 X;  1RX4 A;  3JWK A;  4X5G A;  1RB3 A;  1HFR A;  1RE7 A;  1RX9 A;  3SRU X;  4DPD A;  4KBN A;  1LY4 A;  5DXV A;  4EIZ A;  3QLY A;  4LAG X;  1BOZ A;  3OCH A;  4M7V A;  2ANO A;  2C2T A;  2W3M A;  5CCC A;  1DR3 A;  3EEL A;  2AZN A;  3F0Q X;  2ANQ A;  1J3I A;  4FHB A;  4DP3 A;  3DAT A;  3FS6 A;  3Q1H A;  5HF2 X;  4XT6 A;  3KFY A;  1E26 A;  1JOM A;  1JUV A;  1MVS A;  3FQO A;  3QG2 A;  1RB2 A;  5HUI A;  4KJL A;  3FRE X;  1JOL A;  2W9S A;  1OHK A;  1RA8 A;  4M6K A;  5HPB A;  3DAU A;  1SEJ A;  4KY4 A;  4DFR A;  1DIU A;  3DRC A;  1J3K A;  4HOG A;  2HQP A;  3SAI A;  1DG5 A;  3M09 A;  4KY8 A;  5HQY A;  4M6L A;  3QL0 A;  2INQ A;  1RX7 A;  3NRR A;  2W9T A;  3S3V A;  4PSY A;  3FYV X;  4ECK A;  4XT5 A;  4Q0E A;  2O7P A;  3R33 A;  3SRS X;  3GHV A;  4KJJ A;  2W3A A;  4ELB A;  3NZD A;  1DR7 A;  3NZB X;  5CC9 A;  4XRB A;  3NXV A;  3DFR A;  3SRW X;  3SA2 A;  5ECC A;  5JA3 A;  3UM6 A;  2OBC A;  3SGY A;  2C2S A;  4PTH A;  3RO9 A;  2W3V A;  3IX9 A;  3OAF A;  1D1G A;  3JVX A;  3QLS A;  1RX1 A;  2W9G A;  4X5J A;  3FRF X;  3FQZ A;  4P68 A;  1DR5 A;  1KMV A;  4EJ1 A;  3UM8 A;  3HBB A;  1KLK A;  3EIG A;  1YHO A;  3VCO A;  3IRM A;  3LG4 A;  4OR7 A;  3NU0 A;  3GI2 A;  4KFJ A;  5U26 A;  4LAE X;  2FZJ A;  3EEJ A;  1ZDR A;  3NXR A;  2G6V A;  1DLS A;  2BLA A;  4OSG A;  4EIG A;  1RX6 A;  4H98 A;  4KL9 A;  2D0K A;  3F0S X;  3QGT A;  5ECX A;  3UM5 A;  4KJK A;  1S3W A;  3K2H A;  4QLF A;  4KYA A;  4RGC A;  4XE6 X;  5HT4 A;  5FDA A;  2HXV A;  3FY9 X;  1DR2 A;  3N0H A;  3S9U A;  3IA4 A;  2QK8 A;  1DRA A;  4PDJ A;  5JG0 X;  5HI6 A;  3CL9 A;  4IXE D;  3HJ3 A;  5HF0 X;  2BL9 A;  4P3R A;  3TQA A;  3QLZ A;  2H2Q A;  2W3B A;  2FZH A;  4M2X A;  4Q67 A;  3IRN A;  3DL6 A;  3NZA X;  1RD7 A;  1DYH A;  2KGK A;  3K74 A;  3KGY A;  4CD2 A;  3FQV A;  4P3Q A;  4NX7 A;  4IXF X;  3EEM A;  3GHC A;  4FGH A;  3QLR A;  1AI9 A;  4TU5 X;  1DR4 A;  4H95 A;  1M79 A;  1DR1 A;  1DG8 A;  3QYL A;  3JSU A;  1TDR A;  4LEK X;  3CD2 A;  4PTJ A;  3I3R A;  1IA2 A;  4HOF A;  1DDS A;  3SA1 A;  8DFR A;  4XEC X;  4HA9 A;  2CD2 A;  4G95 A;  1IA4 A;  1M7A A;  4H97 A;  1HFQ A;  3I8A X;  1PD8 A;  6DFR A;  3F0U X;  1DYJ A;  5HSU A;  4HOE A;  2LF1 A;  5U27 A;  3NZC X;  5E8Q A;  3NTZ A;  4P66 A;  4KM0 A;  1DLR A;  1RC4 A;  4DDR A;  3SQY X;  3EX8 A;  5HQZ A;  1OHJ A;  4QI9 A;  1DRE A;  5EAJ A;  4ELF A;  1RF7 A;  1U72 A;  4G8Z X;  3F8Y A;  1DIS A;  3FQF A;  4ELG A;  4KM2 A;  1BZF A;  2HM9 A;  3SRQ X;  2DRC A;  3KY8 A;  2P4G A;  2D5N A;  2DHF A;  1PDB A;  4NX6 A;  2ZZA A;  1LY3 A;  3FRB X;  1RH3 A;  4LAH X;  1DYR A;  1DG7 A;  1U70 A;  1J3J A;  1DYI A;  3K47 A;  2B3Z A;  5HVB A;  3D80 A;  3F0X X;  4PST A;  3FQ0 A;  3TD8 A;  3NXY A;  3IRO A;  4KD7 A;  4XT7 A;  1MVT A;  3RG9 A;  3ZPC A;  3FQC A;  4GH8 A;  4IXG X;  1U71 A;  3F0B X;  4M7U A;  1AOE A;  1S3V A;  3TQ9 A;  3SRR X;  2BLB A;  3JW3 A;  4QLG A;  3TQB A;  1DHI A;  3ZPG A;  3ROA A;  1DRB A;  4KAK A;  1RA1 A;  1CZ3 A;  3F91 A;  3TQ8 A;  3SR5 X;  2OIP A;  4M6J A;  1AO8 A;  1DRF A;  1RG7 A;  3FL9 A;  3S7A A;  1RA9 A;  3CSE A;  1M78 A;  3FL8 A;  3FY8 X;  1LUD A;  4X5F A;  3JTW A;  4Q0D A;  1KMS A;  3QL3 A;  3IA5 A;  2W9H A;  1IA1 A;  3NXT A;  3QLW A;  2CIG A;  3INV A;  1DAJ A;  4HA7 A;  1RA3 A;  4Q6A A;  5HT5 A;  7DFR A;  1S3Y A;  1VJ3 A;  1RA2 A;  1DF7 A;  3GYF A;  3L3R A;  4I13 A;  4ELE A;  2FZI A;  1S3U A;  4KNE A;  3JWC A;  4X5I A;  2JYB A;  3KJS A;  4XT8 A; 
#chains in the Genus database with same CATH topology
 2W3W A;  3NXX A;  4QJC A;  4I1N A;  4KEB A;  4XT4 A;  1DRH A;  3FRD X;  3QYO A;  3E0B A;  2L28 A;  4PSS A;  4X5H A;  3DL5 A;  4QLE A;  1DHJ A;  4H96 A;  4ELH A;  1HFP A;  3K45 A;  1RX2 A;  4G3M A;  2BLC A;  4DPH A;  3F0V X;  3JW5 A;  3DGA A;  3DG8 A;  3F8Z A;  3FYW X;  3QFX A;  3QLX A;  3SH2 A;  3JWM A;  3NXO A;  3KJR A;  5HSR A;  3CLB A;  1CD2 A;  3NZ6 X;  3D84 X;  2ITH A;  1RX5 A;  2GD9 A;  3M08 A;  1VDR A;  3FRA X;  1DR6 A;  1RX3 A;  3GHW A;  5DFR A;  3JWF A;  1QZF A;  4FGG A;  4KLX A;  3EEK A;  1DHF A;  4EIL A;  4QJZ D;  2XW7 A;  1DDR A;  4QHV A;  1PD9 A;  5HVE A;  1IA3 A;  1RX8 A;  3NZ9 X;  1RX4 A;  3JWK A;  4X5G A;  1RB3 A;  1HFR A;  1RE7 A;  1RX9 A;  3SRU X;  4DPD A;  4KBN A;  1LY4 A;  5DXV A;  4EIZ A;  3QLY A;  4LAG X;  1BOZ A;  3OCH A;  4M7V A;  2ANO A;  2C2T A;  2W3M A;  5CCC A;  1DR3 A;  3EEL A;  2AZN A;  3F0Q X;  2ANQ A;  1J3I A;  4FHB A;  4DP3 A;  3DAT A;  3FS6 A;  3Q1H A;  5HF2 X;  4XT6 A;  3KFY A;  1E26 A;  1JOM A;  1JUV A;  1MVS A;  3FQO A;  3QG2 A;  1RB2 A;  5HUI A;  4KJL A;  3FRE X;  1JOL A;  2W9S A;  1OHK A;  1RA8 A;  4M6K A;  5HPB A;  3DAU A;  1SEJ A;  4KY4 A;  4DFR A;  1DIU A;  3DRC A;  1J3K A;  4HOG A;  2HQP A;  3SAI A;  1DG5 A;  3M09 A;  4KY8 A;  5HQY A;  4M6L A;  3QL0 A;  2INQ A;  1RX7 A;  3NRR A;  2W9T A;  3S3V A;  4PSY A;  3FYV X;  4ECK A;  4XT5 A;  4Q0E A;  2O7P A;  3R33 A;  3SRS X;  3GHV A;  4KJJ A;  2W3A A;  4ELB A;  3NZD A;  1DR7 A;  3NZB X;  5CC9 A;  4XRB A;  3NXV A;  3DFR A;  3SRW X;  3SA2 A;  5ECC A;  5JA3 A;  3UM6 A;  2OBC A;  3SGY A;  2C2S A;  4PTH A;  3RO9 A;  2W3V A;  3IX9 A;  3OAF A;  1D1G A;  3JVX A;  3QLS A;  1RX1 A;  2W9G A;  4X5J A;  3FRF X;  3FQZ A;  4P68 A;  1DR5 A;  1KMV A;  4EJ1 A;  3UM8 A;  3HBB A;  1KLK A;  3EIG A;  1YHO A;  3VCO A;  3IRM A;  3LG4 A;  4OR7 A;  3NU0 A;  3GI2 A;  4KFJ A;  5U26 A;  4LAE X;  2FZJ A;  3EEJ A;  1ZDR A;  3NXR A;  2G6V A;  1DLS A;  2BLA A;  4OSG A;  4EIG A;  1RX6 A;  4H98 A;  4KL9 A;  2D0K A;  3F0S X;  3QGT A;  5ECX A;  3UM5 A;  4KJK A;  1S3W A;  3K2H A;  4QLF A;  4KYA A;  4RGC A;  4XE6 X;  5HT4 A;  5FDA A;  2HXV A;  3FY9 X;  1DR2 A;  3N0H A;  3S9U A;  3IA4 A;  2QK8 A;  1DRA A;  4PDJ A;  5JG0 X;  5HI6 A;  3CL9 A;  4IXE D;  3HJ3 A;  5HF0 X;  2BL9 A;  4P3R A;  3TQA A;  3QLZ A;  2H2Q A;  2W3B A;  2FZH A;  4M2X A;  4Q67 A;  3IRN A;  3DL6 A;  3NZA X;  1RD7 A;  1DYH A;  2KGK A;  3K74 A;  3KGY A;  4CD2 A;  3FQV A;  4P3Q A;  4NX7 A;  4IXF X;  3EEM A;  3GHC A;  4FGH A;  3QLR A;  1AI9 A;  4TU5 X;  1DR4 A;  4H95 A;  1M79 A;  1DR1 A;  1DG8 A;  3QYL A;  3JSU A;  1TDR A;  4LEK X;  3CD2 A;  4PTJ A;  3I3R A;  1IA2 A;  4HOF A;  1DDS A;  3SA1 A;  8DFR A;  4XEC X;  4HA9 A;  2CD2 A;  4G95 A;  1IA4 A;  1M7A A;  4H97 A;  1HFQ A;  3I8A X;  1PD8 A;  6DFR A;  3F0U X;  1DYJ A;  5HSU A;  4HOE A;  2LF1 A;  5U27 A;  3NZC X;  5E8Q A;  3NTZ A;  4P66 A;  4KM0 A;  1DLR A;  1RC4 A;  4DDR A;  3SQY X;  3EX8 A;  5HQZ A;  1OHJ A;  4QI9 A;  1DRE A;  5EAJ A;  4ELF A;  1RF7 A;  1U72 A;  4G8Z X;  3F8Y A;  1DIS A;  3FQF A;  4ELG A;  4KM2 A;  1BZF A;  2HM9 A;  3SRQ X;  2DRC A;  3KY8 A;  2P4G A;  2D5N A;  2DHF A;  1PDB A;  4NX6 A;  2ZZA A;  1LY3 A;  3FRB X;  1RH3 A;  4LAH X;  1DYR A;  1DG7 A;  1U70 A;  1J3J A;  1DYI A;  3K47 A;  2B3Z A;  5HVB A;  3D80 A;  3F0X X;  4PST A;  3FQ0 A;  3TD8 A;  3NXY A;  3IRO A;  4KD7 A;  4XT7 A;  1MVT A;  3RG9 A;  3ZPC A;  3FQC A;  4GH8 A;  4IXG X;  1U71 A;  3F0B X;  4M7U A;  1AOE A;  1S3V A;  3TQ9 A;  3SRR X;  2BLB A;  3JW3 A;  4QLG A;  3TQB A;  1DHI A;  3ZPG A;  3ROA A;  1DRB A;  4KAK A;  1RA1 A;  1CZ3 A;  3F91 A;  3TQ8 A;  3SR5 X;  2OIP A;  4M6J A;  1AO8 A;  1DRF A;  1RG7 A;  3FL9 A;  3S7A A;  1RA9 A;  3CSE A;  1M78 A;  3FL8 A;  3FY8 X;  1LUD A;  4X5F A;  3JTW A;  4Q0D A;  1KMS A;  3QL3 A;  3IA5 A;  2W9H A;  1IA1 A;  3NXT A;  3QLW A;  2CIG A;  3INV A;  1DAJ A;  4HA7 A;  1RA3 A;  4Q6A A;  5HT5 A;  7DFR A;  1S3Y A;  1VJ3 A;  1RA2 A;  1DF7 A;  3GYF A;  3L3R A;  4I13 A;  4ELE A;  2FZI A;  1S3U A;  4KNE A;  3JWC A;  4X5I A;  2JYB A;  3KJS A;  4XT8 A; 
#chains in the Genus database with same CATH homology
 2W3W A;  3NXX A;  4QJC A;  4I1N A;  4KEB A;  4XT4 A;  1DRH A;  3FRD X;  3QYO A;  3E0B A;  2L28 A;  4PSS A;  4X5H A;  3DL5 A;  4QLE A;  1DHJ A;  4H96 A;  4ELH A;  1HFP A;  3K45 A;  1RX2 A;  4G3M A;  2BLC A;  4DPH A;  3F0V X;  3JW5 A;  3DGA A;  3DG8 A;  3F8Z A;  3FYW X;  3QFX A;  3QLX A;  3SH2 A;  3JWM A;  3NXO A;  3KJR A;  5HSR A;  3CLB A;  1CD2 A;  3NZ6 X;  3D84 X;  2ITH A;  1RX5 A;  2GD9 A;  3M08 A;  1VDR A;  3FRA X;  1DR6 A;  1RX3 A;  3GHW A;  5DFR A;  3JWF A;  1QZF A;  4FGG A;  4KLX A;  3EEK A;  1DHF A;  4EIL A;  4QJZ D;  2XW7 A;  1DDR A;  4QHV A;  1PD9 A;  5HVE A;  1IA3 A;  1RX8 A;  3NZ9 X;  1RX4 A;  3JWK A;  4X5G A;  1RB3 A;  1HFR A;  1RE7 A;  1RX9 A;  3SRU X;  4DPD A;  4KBN A;  1LY4 A;  5DXV A;  4EIZ A;  3QLY A;  4LAG X;  1BOZ A;  3OCH A;  4M7V A;  2ANO A;  2C2T A;  2W3M A;  5CCC A;  1DR3 A;  3EEL A;  2AZN A;  3F0Q X;  2ANQ A;  1J3I A;  4FHB A;  4DP3 A;  3DAT A;  3FS6 A;  3Q1H A;  5HF2 X;  4XT6 A;  3KFY A;  1E26 A;  1JOM A;  1JUV A;  1MVS A;  3FQO A;  3QG2 A;  1RB2 A;  5HUI A;  4KJL A;  3FRE X;  1JOL A;  2W9S A;  1OHK A;  1RA8 A;  4M6K A;  5HPB A;  3DAU A;  1SEJ A;  4KY4 A;  4DFR A;  1DIU A;  3DRC A;  1J3K A;  4HOG A;  2HQP A;  3SAI A;  1DG5 A;  3M09 A;  4KY8 A;  5HQY A;  4M6L A;  3QL0 A;  2INQ A;  1RX7 A;  3NRR A;  2W9T A;  3S3V A;  4PSY A;  3FYV X;  4ECK A;  4XT5 A;  4Q0E A;  2O7P A;  3R33 A;  3SRS X;  3GHV A;  4KJJ A;  2W3A A;  4ELB A;  3NZD A;  1DR7 A;  3NZB X;  5CC9 A;  4XRB A;  3NXV A;  3DFR A;  3SRW X;  3SA2 A;  5ECC A;  5JA3 A;  3UM6 A;  2OBC A;  3SGY A;  2C2S A;  4PTH A;  3RO9 A;  2W3V A;  3IX9 A;  3OAF A;  1D1G A;  3JVX A;  3QLS A;  1RX1 A;  2W9G A;  4X5J A;  3FRF X;  3FQZ A;  4P68 A;  1DR5 A;  1KMV A;  4EJ1 A;  3UM8 A;  3HBB A;  1KLK A;  3EIG A;  1YHO A;  3VCO A;  3IRM A;  3LG4 A;  4OR7 A;  3NU0 A;  3GI2 A;  4KFJ A;  5U26 A;  4LAE X;  2FZJ A;  3EEJ A;  1ZDR A;  3NXR A;  2G6V A;  1DLS A;  2BLA A;  4OSG A;  4EIG A;  1RX6 A;  4H98 A;  4KL9 A;  2D0K A;  3F0S X;  3QGT A;  5ECX A;  3UM5 A;  4KJK A;  1S3W A;  3K2H A;  4QLF A;  4KYA A;  4RGC A;  4XE6 X;  5HT4 A;  5FDA A;  2HXV A;  3FY9 X;  1DR2 A;  3N0H A;  3S9U A;  3IA4 A;  2QK8 A;  1DRA A;  4PDJ A;  5JG0 X;  5HI6 A;  3CL9 A;  4IXE D;  3HJ3 A;  5HF0 X;  2BL9 A;  4P3R A;  3TQA A;  3QLZ A;  2H2Q A;  2W3B A;  2FZH A;  4M2X A;  4Q67 A;  3IRN A;  3DL6 A;  3NZA X;  1RD7 A;  1DYH A;  2KGK A;  3K74 A;  3KGY A;  4CD2 A;  3FQV A;  4P3Q A;  4NX7 A;  4IXF X;  3EEM A;  3GHC A;  4FGH A;  3QLR A;  1AI9 A;  4TU5 X;  1DR4 A;  4H95 A;  1M79 A;  1DR1 A;  1DG8 A;  3QYL A;  3JSU A;  1TDR A;  4LEK X;  3CD2 A;  4PTJ A;  3I3R A;  1IA2 A;  4HOF A;  1DDS A;  3SA1 A;  8DFR A;  4XEC X;  4HA9 A;  2CD2 A;  4G95 A;  1IA4 A;  1M7A A;  4H97 A;  1HFQ A;  3I8A X;  1PD8 A;  6DFR A;  3F0U X;  1DYJ A;  5HSU A;  4HOE A;  2LF1 A;  5U27 A;  3NZC X;  5E8Q A;  3NTZ A;  4P66 A;  4KM0 A;  1DLR A;  1RC4 A;  4DDR A;  3SQY X;  3EX8 A;  5HQZ A;  1OHJ A;  4QI9 A;  1DRE A;  5EAJ A;  4ELF A;  1RF7 A;  1U72 A;  4G8Z X;  3F8Y A;  1DIS A;  3FQF A;  4ELG A;  4KM2 A;  1BZF A;  2HM9 A;  3SRQ X;  2DRC A;  3KY8 A;  2P4G A;  2D5N A;  2DHF A;  1PDB A;  4NX6 A;  2ZZA A;  1LY3 A;  3FRB X;  1RH3 A;  4LAH X;  1DYR A;  1DG7 A;  1U70 A;  1J3J A;  1DYI A;  3K47 A;  2B3Z A;  5HVB A;  3D80 A;  3F0X X;  4PST A;  3FQ0 A;  3TD8 A;  3NXY A;  3IRO A;  4KD7 A;  4XT7 A;  1MVT A;  3RG9 A;  3ZPC A;  3FQC A;  4GH8 A;  4IXG X;  1U71 A;  3F0B X;  4M7U A;  1AOE A;  1S3V A;  3TQ9 A;  3SRR X;  2BLB A;  3JW3 A;  4QLG A;  3TQB A;  1DHI A;  3ZPG A;  3ROA A;  1DRB A;  4KAK A;  1RA1 A;  1CZ3 A;  3F91 A;  3TQ8 A;  3SR5 X;  2OIP A;  4M6J A;  1AO8 A;  1DRF A;  1RG7 A;  3FL9 A;  3S7A A;  1RA9 A;  3CSE A;  1M78 A;  3FL8 A;  3FY8 X;  1LUD A;  4X5F A;  3JTW A;  4Q0D A;  1KMS A;  3QL3 A;  3IA5 A;  2W9H A;  1IA1 A;  3NXT A;  3QLW A;  2CIG A;  3INV A;  1DAJ A;  4HA7 A;  1RA3 A;  4Q6A A;  5HT5 A;  7DFR A;  1S3Y A;  1VJ3 A;  1RA2 A;  1DF7 A;  3GYF A;  3L3R A;  4I13 A;  4ELE A;  2FZI A;  1S3U A;  4KNE A;  3JWC A;  4X5I A;  2JYB A;  3KJS A;  4XT8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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