3NXXA

Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro-2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 58
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2010-07-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3nxxA00
5HI6A 5HVEA 4KAKA 1RA9A 3QFXA 5U26A 2AZNA 3KFYA 4DPHA 2HXVA 2W3WA 3NXTA 3JSUA 3UM6A 1IA4A 3JTWA 3NXYA 1LY4A 3INVA 1HFPA 5U27A 1HFRA 3CL9A 4Q67A 4X5JA 3UM5A 3CD2A 4ELBA 2OIPA 1AOEA 4X5GA 3NXXA 4G8ZX 1AO8A 3K45A 4QI9A 4QJZD 1RG7A 3NZDA 4Q0DA 4KJJA 1RA1A 3TQAA 3EX8A 4HA9A 3ZPGA 3NZBX 4X5FA 3SRSX 4KD7A 2BLCA 3F8YA 1E26A 3FL8A 2XW7A 3D80A 1IA1A 2CD2A 4QLFA 3DATA 3EEJA 3KGYA 1RA3A 1DR5A 4G3MA 1IA3A 3N0HA 5DXVA 3SA2A 4FGHA 3EELA 3TQBA 2FZHA 1DR1A 1DRFA 3F0BX 3GHVA 4KEBA 3DL6A 1DRHA 4PDJA 3IX9A 3QYLA 4LAHX 1DG8A 3JWMA 2HQPA 2G6VA 1M7AA 4HOFA 3FY9X 4X5IA 2L28A 1RX9A 4QLGA 1RX7A 5E8QA 4XECX 2HM9A 1DR6A 2H2QA 3QG2A 3GHCA 4ELFA 2W9GA 3TD8A 3FQVA 3NZ6X 3DGAA 1DYIA 1KLKA 3E0BA 1KMVA 1DLRA 3SRQX 1DG5A 3QLYA 4XT4A 2W3MA 1D1GA 3QL0A 1YHOA 3QLZA 4DP3A 3F8ZA 5EAJA 1RX4A 4PSYA 3I8AX 3SQYX 4M6LA 1DYHA 2QK8A 2P4GA 3NZ9X 2GD9A 3GI2A 3Q1HA 1OHJA 3JVXA 3QLSA 3JWKA 4X5HA 1RX2A 2BLAA 3F91A 3KJRA 1BOZA 1DR3A 3EIGA 3I3RA 1RB3A 1DDSA 4G95A 1MVSA 3IA5A 3NXVA 3KY8A 3EEMA 4KLXA 4PTHA 4KL9A 1DISA 1RF7A 3QLRA 1QZFA 4DDRA 4H96A 2DRCA 4ELGA 4H95A 3FQOA 2C2TA 1PDBA 5DFRA 4ELEA 4KM2A 3DL5A 3FY8X 4XT8A 3SRWX 3FRBX 1LY3A 3K74A 3L3RA 3QLXA 1DRBA 3HJ3A 4P3RA 1DHFA 1DHIA 3RO9A 3EEKA 5HF0X 5HSUA 3OCHA 4FGGA 4M6JA 3F0XX 4FHBA 1JOLA 3SH2A 3SR5X 1DHJA 4HOGA 1RX5A 4KM0A 1DAJA 1S3VA 3FYWX 6DFRA 1DR4A 3R33A 5ECCA 1S3UA 4H97A 3TQ9A 3OAFA 1DYJA 4KY8A 1RC4A 3FRDX 4XT7A 4IXGX 1VJ3A 2W9HA 1J3IA 1AI9A 4KY4A 3JW5A 4KBNA 1CD2A 4HA7A 3QLWA 3HBBA 4Q6AA 3QL3A 3FS6A 3SGYA 1DF7A 1RH3A 3F0SX 3F0VX 4HOEA 3GHWA 4PTJA 5HSRA 1SEJA 1RE7A 1S3WA 3JWFA 1HFQA 5ECXA 2ZZAA 1M78A 1RX3A 3QYOA 4IXFX 4KFJA 1U70A 1DREA 5FDAA 4KNEA 2FZIA 3NTZA 3FQFA 1CZ3A 4XT5A 1RX1A 3K47A 4LAEX 3KJSA 5HF2X 4M6KA 4I13A 2W9TA 2W9SA 4LEKX 5CCCA 3S7AA 1J3JA 3DFRA 4PSTA 3CSEA 1DIUA 1PD8A 5HUIA 1RA8A 2ITHA 3FYVX 4EILA 4M7UA 2C2SA 4IXED 4KJKA 4H98A 3D84X 1J3KA 4CD2A 4NX7A 2ANOA 3NZAX 2D0KA 5JG0X 4DFRA 3ROAA 2W3AA 3FREX 5HT5A 3M09A 1U71A 1LUDA 4KYAA 3F0QX 1DG7A 2FZJA 3RG9A 1JUVA 2O7PA 3IRMA 1VDRA 4GH8A 4NX6A 3FRAX 4P66A 3NU0A 3SAIA 5HQZA 3IROA 4OR7A 4EIZA 4DPDA 3S3VA 4TU5X 1U72A 2W3BA 4EIGA 3VCOA 1S3YA 3M08A 3DG8A 4XRBA 1ZDRA 3K2HA 4OSGA 4KJLA 1M79A 3UM8A 4ELHA 1BZFA 3DRCA 4I1NA 1OHKA 2JYBA 3NXOA 3FQZA 4M7VA 7DFRA 1JOMA 2KGKA 3S9UA 1RX6A 4P68A 1MVTA 2INQA 8DFRA 3NXRA 1RB2A 4LAGX 2LF1A 3CLBA 4XE6X 3TQ8A 4EJ1A 4Q0EA 5HPBA 1DLSA 5JA3A 3F0UX 4P3QA 4PSSA 4QHVA 3ZPCA 2OBCA 2B3ZA 3JWCA 3SA1A 4RGCA 3FRFX 3QGTA 3DAUA 4M2XA 1KMSA 2BL9A 3GYFA 5HVBA 2CIGA 1RX8A 3FQCA 3NZCX 5CC9A 1RA2A 1RD7A 2D5NA 1DYRA 3FL9A 3SRRX 4QLEA 5HQYA 4ECKA 2DHFA 3JW3A 2ANQA 1DRAA 3LG4A 3IA4A 4QJCA 3FQ0A 4XT6A 3IRNA 1PD9A 1TDRA 1DDRA 2W3VA 1IA2A 3SRUX 5HT4A 2BLBA 1DR2A 1DR7A 3NRRA
chains in the Genus database with same CATH superfamily
5HI6A 5HVEA 4KAKA 1RA9A 3QFXA 5U26A 2AZNA 3KFYA 4DPHA 2HXVA 2W3WA 3NXTA 3JSUA 3UM6A 1IA4A 3JTWA 3NXYA 1LY4A 3INVA 1HFPA 5U27A 1HFRA 3CL9A 4Q67A 4X5JA 3UM5A 3CD2A 4ELBA 2OIPA 1AOEA 4X5GA 3NXXA 4G8ZX 1AO8A 3K45A 4QI9A 4QJZD 1RG7A 3NZDA 4Q0DA 4KJJA 1RA1A 3TQAA 3EX8A 4HA9A 3ZPGA 3NZBX 4X5FA 3SRSX 4KD7A 2BLCA 3F8YA 1E26A 3FL8A 2XW7A 3D80A 1IA1A 2CD2A 4QLFA 3DATA 3EEJA 3KGYA 1RA3A 1DR5A 4G3MA 1IA3A 3N0HA 5DXVA 3SA2A 4FGHA 3EELA 3TQBA 2FZHA 1DR1A 1DRFA 3F0BX 3GHVA 4KEBA 3DL6A 1DRHA 4PDJA 3IX9A 3QYLA 4LAHX 1DG8A 3JWMA 2HQPA 2G6VA 1M7AA 4HOFA 3FY9X 4X5IA 2L28A 1RX9A 4QLGA 1RX7A 5E8QA 4XECX 2HM9A 1DR6A 2H2QA 3QG2A 3GHCA 4ELFA 2W9GA 3TD8A 3FQVA 3NZ6X 3DGAA 1DYIA 1KLKA 3E0BA 1KMVA 1DLRA 3SRQX 1DG5A 3QLYA 4XT4A 2W3MA 1D1GA 3QL0A 1YHOA 3QLZA 4DP3A 3F8ZA 5EAJA 1RX4A 4PSYA 3I8AX 3SQYX 4M6LA 1DYHA 2QK8A 2P4GA 3NZ9X 2GD9A 3GI2A 3Q1HA 1OHJA 3JVXA 3QLSA 3JWKA 4X5HA 1RX2A 2BLAA 3F91A 3KJRA 1BOZA 1DR3A 3EIGA 3I3RA 1RB3A 1DDSA 4G95A 1MVSA 3IA5A 3NXVA 3KY8A 3EEMA 4KLXA 4PTHA 4KL9A 1DISA 1RF7A 3QLRA 1QZFA 4DDRA 4H96A 2DRCA 4ELGA 4H95A 3FQOA 2C2TA 1PDBA 5DFRA 4ELEA 4KM2A 3DL5A 3FY8X 4XT8A 3SRWX 3FRBX 1LY3A 3K74A 3L3RA 3QLXA 1DRBA 3HJ3A 4P3RA 1DHFA 1DHIA 3RO9A 3EEKA 5HF0X 5HSUA 3OCHA 4FGGA 4M6JA 3F0XX 4FHBA 1JOLA 3SH2A 3SR5X 1DHJA 4HOGA 1RX5A 4KM0A 1DAJA 1S3VA 3FYWX 6DFRA 1DR4A 3R33A 5ECCA 1S3UA 4H97A 3TQ9A 3OAFA 1DYJA 4KY8A 1RC4A 3FRDX 4XT7A 4IXGX 1VJ3A 2W9HA 1J3IA 1AI9A 4KY4A 3JW5A 4KBNA 1CD2A 4HA7A 3QLWA 3HBBA 4Q6AA 3QL3A 3FS6A 3SGYA 1DF7A 1RH3A 3F0SX 3F0VX 4HOEA 3GHWA 4PTJA 5HSRA 1SEJA 1RE7A 1S3WA 3JWFA 1HFQA 5ECXA 2ZZAA 1M78A 1RX3A 3QYOA 4IXFX 4KFJA 1U70A 1DREA 5FDAA 4KNEA 2FZIA 3NTZA 3FQFA 1CZ3A 4XT5A 1RX1A 3K47A 4LAEX 3KJSA 5HF2X 4M6KA 4I13A 2W9TA 2W9SA 4LEKX 5CCCA 3S7AA 1J3JA 3DFRA 4PSTA 3CSEA 1DIUA 1PD8A 5HUIA 1RA8A 2ITHA 3FYVX 4EILA 4M7UA 2C2SA 4IXED 4KJKA 4H98A 3D84X 1J3KA 4CD2A 4NX7A 2ANOA 3NZAX 2D0KA 5JG0X 4DFRA 3ROAA 2W3AA 3FREX 5HT5A 3M09A 1U71A 1LUDA 4KYAA 3F0QX 1DG7A 2FZJA 3RG9A 1JUVA 2O7PA 3IRMA 1VDRA 4GH8A 4NX6A 3FRAX 4P66A 3NU0A 3SAIA 5HQZA 3IROA 4OR7A 4EIZA 4DPDA 3S3VA 4TU5X 1U72A 2W3BA 4EIGA 3VCOA 1S3YA 3M08A 3DG8A 4XRBA 1ZDRA 3K2HA 4OSGA 4KJLA 1M79A 3UM8A 4ELHA 1BZFA 3DRCA 4I1NA 1OHKA 2JYBA 3NXOA 3FQZA 4M7VA 7DFRA 1JOMA 2KGKA 3S9UA 1RX6A 4P68A 1MVTA 2INQA 8DFRA 3NXRA 1RB2A 4LAGX 2LF1A 3CLBA 4XE6X 3TQ8A 4EJ1A 4Q0EA 5HPBA 1DLSA 5JA3A 3F0UX 4P3QA 4PSSA 4QHVA 3ZPCA 2OBCA 2B3ZA 3JWCA 3SA1A 4RGCA 3FRFX 3QGTA 3DAUA 4M2XA 1KMSA 2BL9A 3GYFA 5HVBA 2CIGA 1RX8A 3FQCA 3NZCX 5CC9A 1RA2A 1RD7A 2D5NA 1DYRA 3FL9A 3SRRX 4QLEA 5HQYA 4ECKA 2DHFA 3JW3A 2ANQA 1DRAA 3LG4A 3IA4A 4QJCA 3FQ0A 4XT6A 3IRNA 1PD9A 1TDRA 1DDRA 2W3VA 1IA2A 3SRUX 5HT4A 2BLBA 1DR2A 1DR7A 3NRRA
chains in the Genus database with same CATH topology
5HI6A 5HVEA 4KAKA 1RA9A 3QFXA 5U26A 2AZNA 3KFYA 4DPHA 2HXVA 2W3WA 3NXTA 3JSUA 3UM6A 1IA4A 3JTWA 3NXYA 1LY4A 3INVA 1HFPA 5U27A 1HFRA 3CL9A 4Q67A 4X5JA 3UM5A 3CD2A 4ELBA 2OIPA 1AOEA 4X5GA 3NXXA 4G8ZX 1AO8A 3K45A 4QI9A 4QJZD 1RG7A 3NZDA 4Q0DA 4KJJA 1RA1A 3TQAA 3EX8A 4HA9A 3ZPGA 3NZBX 4X5FA 3SRSX 4KD7A 2BLCA 3F8YA 1E26A 3FL8A 2XW7A 3D80A 1IA1A 2CD2A 4QLFA 3DATA 3EEJA 3KGYA 1RA3A 1DR5A 4G3MA 1IA3A 3N0HA 5DXVA 3SA2A 4FGHA 3EELA 3TQBA 2FZHA 1DR1A 1DRFA 3F0BX 3GHVA 4KEBA 3DL6A 1DRHA 4PDJA 3IX9A 3QYLA 4LAHX 1DG8A 3JWMA 2HQPA 2G6VA 1M7AA 4HOFA 3FY9X 4X5IA 2L28A 1RX9A 4QLGA 1RX7A 5E8QA 4XECX 2HM9A 1DR6A 2H2QA 3QG2A 3GHCA 4ELFA 2W9GA 3TD8A 3FQVA 3NZ6X 3DGAA 1DYIA 1KLKA 3E0BA 1KMVA 1DLRA 3SRQX 1DG5A 3QLYA 4XT4A 2W3MA 1D1GA 3QL0A 1YHOA 3QLZA 4DP3A 3F8ZA 5EAJA 1RX4A 4PSYA 3I8AX 3SQYX 4M6LA 1DYHA 2QK8A 2P4GA 3NZ9X 2GD9A 3GI2A 3Q1HA 1OHJA 3JVXA 3QLSA 3JWKA 4X5HA 1RX2A 2BLAA 3F91A 3KJRA 1BOZA 1DR3A 3EIGA 3I3RA 1RB3A 1DDSA 4G95A 1MVSA 3IA5A 3NXVA 3KY8A 3EEMA 4KLXA 4PTHA 4KL9A 1DISA 1RF7A 3QLRA 1QZFA 4DDRA 4H96A 2DRCA 4ELGA 4H95A 3FQOA 2C2TA 1PDBA 5DFRA 4ELEA 4KM2A 3DL5A 3FY8X 4XT8A 3SRWX 3FRBX 1LY3A 3K74A 3L3RA 3QLXA 1DRBA 3HJ3A 4P3RA 1DHFA 1DHIA 3RO9A 3EEKA 5HF0X 5HSUA 3OCHA 4FGGA 4M6JA 3F0XX 4FHBA 1JOLA 3SH2A 3SR5X 1DHJA 4HOGA 1RX5A 4KM0A 1DAJA 1S3VA 3FYWX 6DFRA 1DR4A 3R33A 5ECCA 1S3UA 4H97A 3TQ9A 3OAFA 1DYJA 4KY8A 1RC4A 3FRDX 4XT7A 4IXGX 1VJ3A 2W9HA 1J3IA 1AI9A 4KY4A 3JW5A 4KBNA 1CD2A 4HA7A 3QLWA 3HBBA 4Q6AA 3QL3A 3FS6A 3SGYA 1DF7A 1RH3A 3F0SX 3F0VX 4HOEA 3GHWA 4PTJA 5HSRA 1SEJA 1RE7A 1S3WA 3JWFA 1HFQA 5ECXA 2ZZAA 1M78A 1RX3A 3QYOA 4IXFX 4KFJA 1U70A 1DREA 5FDAA 4KNEA 2FZIA 3NTZA 3FQFA 1CZ3A 4XT5A 1RX1A 3K47A 4LAEX 3KJSA 5HF2X 4M6KA 4I13A 2W9TA 2W9SA 4LEKX 5CCCA 3S7AA 1J3JA 3DFRA 4PSTA 3CSEA 1DIUA 1PD8A 5HUIA 1RA8A 2ITHA 3FYVX 4EILA 4M7UA 2C2SA 4IXED 4KJKA 4H98A 3D84X 1J3KA 4CD2A 4NX7A 2ANOA 3NZAX 2D0KA 5JG0X 4DFRA 3ROAA 2W3AA 3FREX 5HT5A 3M09A 1U71A 1LUDA 4KYAA 3F0QX 1DG7A 2FZJA 3RG9A 1JUVA 2O7PA 3IRMA 1VDRA 4GH8A 4NX6A 3FRAX 4P66A 3NU0A 3SAIA 5HQZA 3IROA 4OR7A 4EIZA 4DPDA 3S3VA 4TU5X 1U72A 2W3BA 4EIGA 3VCOA 1S3YA 3M08A 3DG8A 4XRBA 1ZDRA 3K2HA 4OSGA 4KJLA 1M79A 3UM8A 4ELHA 1BZFA 3DRCA 4I1NA 1OHKA 2JYBA 3NXOA 3FQZA 4M7VA 7DFRA 1JOMA 2KGKA 3S9UA 1RX6A 4P68A 1MVTA 2INQA 8DFRA 3NXRA 1RB2A 4LAGX 2LF1A 3CLBA 4XE6X 3TQ8A 4EJ1A 4Q0EA 5HPBA 1DLSA 5JA3A 3F0UX 4P3QA 4PSSA 4QHVA 3ZPCA 2OBCA 2B3ZA 3JWCA 3SA1A 4RGCA 3FRFX 3QGTA 3DAUA 4M2XA 1KMSA 2BL9A 3GYFA 5HVBA 2CIGA 1RX8A 3FQCA 3NZCX 5CC9A 1RA2A 1RD7A 2D5NA 1DYRA 3FL9A 3SRRX 4QLEA 5HQYA 4ECKA 2DHFA 3JW3A 2ANQA 1DRAA 3LG4A 3IA4A 4QJCA 3FQ0A 4XT6A 3IRNA 1PD9A 1TDRA 1DDRA 2W3VA 1IA2A 3SRUX 5HT4A 2BLBA 1DR2A 1DR7A 3NRRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HI6 A;  5HVE A;  4KAK A;  1RA9 A;  3QFX A;  5U26 A;  2AZN A;  3KFY A;  4DPH A;  2HXV A;  2W3W A;  3NXT A;  3JSU A;  3UM6 A;  1IA4 A;  3JTW A;  3NXY A;  1LY4 A;  3INV A;  1HFP A;  5U27 A;  1HFR A;  3CL9 A;  4Q67 A;  4X5J A;  3UM5 A;  3CD2 A;  4ELB A;  2OIP A;  1AOE A;  4X5G A;  3NXX A;  4G8Z X;  1AO8 A;  3K45 A;  4QI9 A;  4QJZ D;  1RG7 A;  3NZD A;  4Q0D A;  4KJJ A;  1RA1 A;  3TQA A;  3EX8 A;  4HA9 A;  3ZPG A;  3NZB X;  4X5F A;  3SRS X;  4KD7 A;  2BLC A;  3F8Y A;  1E26 A;  3FL8 A;  2XW7 A;  3D80 A;  1IA1 A;  2CD2 A;  4QLF A;  3DAT A;  3EEJ A;  3KGY A;  1RA3 A;  1DR5 A;  4G3M A;  1IA3 A;  3N0H A;  5DXV A;  3SA2 A;  4FGH A;  3EEL A;  3TQB A;  2FZH A;  1DR1 A;  1DRF A;  3F0B X;  3GHV A;  4KEB A;  3DL6 A;  1DRH A;  4PDJ A;  3IX9 A;  3QYL A;  4LAH X;  1DG8 A;  3JWM A;  2HQP A;  2G6V A;  1M7A A;  4HOF A;  3FY9 X;  4X5I A;  2L28 A;  1RX9 A;  4QLG A;  1RX7 A;  5E8Q A;  4XEC X;  2HM9 A;  1DR6 A;  2H2Q A;  3QG2 A;  3GHC A;  4ELF A;  2W9G A;  3TD8 A;  3FQV A;  3NZ6 X;  3DGA A;  1DYI A;  1KLK A;  3E0B A;  1KMV A;  1DLR A;  3SRQ X;  1DG5 A;  3QLY A;  4XT4 A;  2W3M A;  1D1G A;  3QL0 A;  1YHO A;  3QLZ A;  4DP3 A;  3F8Z A;  5EAJ A;  1RX4 A;  4PSY A;  3I8A X;  3SQY X;  4M6L A;  1DYH A;  2QK8 A;  2P4G A;  3NZ9 X;  2GD9 A;  3GI2 A;  3Q1H A;  1OHJ A;  3JVX A;  3QLS A;  3JWK A;  4X5H A;  1RX2 A;  2BLA A;  3F91 A;  3KJR A;  1BOZ A;  1DR3 A;  3EIG A;  3I3R A;  1RB3 A;  1DDS A;  4G95 A;  1MVS A;  3IA5 A;  3NXV A;  3KY8 A;  3EEM A;  4KLX A;  4PTH A;  4KL9 A;  1DIS A;  1RF7 A;  3QLR A;  1QZF A;  4DDR A;  4H96 A;  2DRC A;  4ELG A;  4H95 A;  3FQO A;  2C2T A;  1PDB A;  5DFR A;  4ELE A;  4KM2 A;  3DL5 A;  3FY8 X;  4XT8 A;  3SRW X;  3FRB X;  1LY3 A;  3K74 A;  3L3R A;  3QLX A;  1DRB A;  3HJ3 A;  4P3R A;  1DHF A;  1DHI A;  3RO9 A;  3EEK A;  5HF0 X;  5HSU A;  3OCH A;  4FGG A;  4M6J A;  3F0X X;  4FHB A;  1JOL A;  3SH2 A;  3SR5 X;  1DHJ A;  4HOG A;  1RX5 A;  4KM0 A;  1DAJ A;  1S3V A;  3FYW X;  6DFR A;  1DR4 A;  3R33 A;  5ECC A;  1S3U A;  4H97 A;  3TQ9 A;  3OAF A;  1DYJ A;  4KY8 A;  1RC4 A;  3FRD X;  4XT7 A;  4IXG X;  1VJ3 A;  2W9H A;  1J3I A;  1AI9 A;  4KY4 A;  3JW5 A;  4KBN A;  1CD2 A;  4HA7 A;  3QLW A;  3HBB A;  4Q6A A;  3QL3 A;  3FS6 A;  3SGY A;  1DF7 A;  1RH3 A;  3F0S X;  3F0V X;  4HOE A;  3GHW A;  4PTJ A;  5HSR A;  1SEJ A;  1RE7 A;  1S3W A;  3JWF A;  1HFQ A;  5ECX A;  2ZZA A;  1M78 A;  1RX3 A;  3QYO A;  4IXF X;  4KFJ A;  1U70 A;  1DRE A;  5FDA A;  4KNE A;  2FZI A;  3NTZ A;  3FQF A;  1CZ3 A;  4XT5 A;  1RX1 A;  3K47 A;  4LAE X;  3KJS A;  5HF2 X;  4M6K A;  4I13 A;  2W9T A;  2W9S A;  4LEK X;  5CCC A;  3S7A A;  1J3J A;  3DFR A;  4PST A;  3CSE A;  1DIU A;  1PD8 A;  5HUI A;  1RA8 A;  2ITH A;  3FYV X;  4EIL A;  4M7U A;  2C2S A;  4IXE D;  4KJK A;  4H98 A;  3D84 X;  1J3K A;  4CD2 A;  4NX7 A;  2ANO A;  3NZA X;  2D0K A;  5JG0 X;  4DFR A;  3ROA A;  2W3A A;  3FRE X;  5HT5 A;  3M09 A;  1U71 A;  1LUD A;  4KYA A;  3F0Q X;  1DG7 A;  2FZJ A;  3RG9 A;  1JUV A;  2O7P A;  3IRM A;  1VDR A;  4GH8 A;  4NX6 A;  3FRA X;  4P66 A;  3NU0 A;  3SAI A;  5HQZ A;  3IRO A;  4OR7 A;  4EIZ A;  4DPD A;  3S3V A;  4TU5 X;  1U72 A;  2W3B A;  4EIG A;  3VCO A;  1S3Y A;  3M08 A;  3DG8 A;  4XRB A;  1ZDR A;  3K2H A;  4OSG A;  4KJL A;  1M79 A;  3UM8 A;  4ELH A;  1BZF A;  3DRC A;  4I1N A;  1OHK A;  2JYB A;  3NXO A;  3FQZ A;  4M7V A;  7DFR A;  1JOM A;  2KGK A;  3S9U A;  1RX6 A;  4P68 A;  1MVT A;  2INQ A;  8DFR A;  3NXR A;  1RB2 A;  4LAG X;  2LF1 A;  3CLB A;  4XE6 X;  3TQ8 A;  4EJ1 A;  4Q0E A;  5HPB A;  1DLS A;  5JA3 A;  3F0U X;  4P3Q A;  4PSS A;  4QHV A;  3ZPC A;  2OBC A;  2B3Z A;  3JWC A;  3SA1 A;  4RGC A;  3FRF X;  3QGT A;  3DAU A;  4M2X A;  1KMS A;  2BL9 A;  3GYF A;  5HVB A;  2CIG A;  1RX8 A;  3FQC A;  3NZC X;  5CC9 A;  1RA2 A;  1RD7 A;  2D5N A;  1DYR A;  3FL9 A;  3SRR X;  4QLE A;  5HQY A;  4ECK A;  2DHF A;  3JW3 A;  2ANQ A;  1DRA A;  3LG4 A;  3IA4 A;  4QJC A;  3FQ0 A;  4XT6 A;  3IRN A;  1PD9 A;  1TDR A;  1DDR A;  2W3V A;  1IA2 A;  3SRU X;  5HT4 A;  2BLB A;  1DR2 A;  1DR7 A;  3NRR A; 
#chains in the Genus database with same CATH topology
 5HI6 A;  5HVE A;  4KAK A;  1RA9 A;  3QFX A;  5U26 A;  2AZN A;  3KFY A;  4DPH A;  2HXV A;  2W3W A;  3NXT A;  3JSU A;  3UM6 A;  1IA4 A;  3JTW A;  3NXY A;  1LY4 A;  3INV A;  1HFP A;  5U27 A;  1HFR A;  3CL9 A;  4Q67 A;  4X5J A;  3UM5 A;  3CD2 A;  4ELB A;  2OIP A;  1AOE A;  4X5G A;  3NXX A;  4G8Z X;  1AO8 A;  3K45 A;  4QI9 A;  4QJZ D;  1RG7 A;  3NZD A;  4Q0D A;  4KJJ A;  1RA1 A;  3TQA A;  3EX8 A;  4HA9 A;  3ZPG A;  3NZB X;  4X5F A;  3SRS X;  4KD7 A;  2BLC A;  3F8Y A;  1E26 A;  3FL8 A;  2XW7 A;  3D80 A;  1IA1 A;  2CD2 A;  4QLF A;  3DAT A;  3EEJ A;  3KGY A;  1RA3 A;  1DR5 A;  4G3M A;  1IA3 A;  3N0H A;  5DXV A;  3SA2 A;  4FGH A;  3EEL A;  3TQB A;  2FZH A;  1DR1 A;  1DRF A;  3F0B X;  3GHV A;  4KEB A;  3DL6 A;  1DRH A;  4PDJ A;  3IX9 A;  3QYL A;  4LAH X;  1DG8 A;  3JWM A;  2HQP A;  2G6V A;  1M7A A;  4HOF A;  3FY9 X;  4X5I A;  2L28 A;  1RX9 A;  4QLG A;  1RX7 A;  5E8Q A;  4XEC X;  2HM9 A;  1DR6 A;  2H2Q A;  3QG2 A;  3GHC A;  4ELF A;  2W9G A;  3TD8 A;  3FQV A;  3NZ6 X;  3DGA A;  1DYI A;  1KLK A;  3E0B A;  1KMV A;  1DLR A;  3SRQ X;  1DG5 A;  3QLY A;  4XT4 A;  2W3M A;  1D1G A;  3QL0 A;  1YHO A;  3QLZ A;  4DP3 A;  3F8Z A;  5EAJ A;  1RX4 A;  4PSY A;  3I8A X;  3SQY X;  4M6L A;  1DYH A;  2QK8 A;  2P4G A;  3NZ9 X;  2GD9 A;  3GI2 A;  3Q1H A;  1OHJ A;  3JVX A;  3QLS A;  3JWK A;  4X5H A;  1RX2 A;  2BLA A;  3F91 A;  3KJR A;  1BOZ A;  1DR3 A;  3EIG A;  3I3R A;  1RB3 A;  1DDS A;  4G95 A;  1MVS A;  3IA5 A;  3NXV A;  3KY8 A;  3EEM A;  4KLX A;  4PTH A;  4KL9 A;  1DIS A;  1RF7 A;  3QLR A;  1QZF A;  4DDR A;  4H96 A;  2DRC A;  4ELG A;  4H95 A;  3FQO A;  2C2T A;  1PDB A;  5DFR A;  4ELE A;  4KM2 A;  3DL5 A;  3FY8 X;  4XT8 A;  3SRW X;  3FRB X;  1LY3 A;  3K74 A;  3L3R A;  3QLX A;  1DRB A;  3HJ3 A;  4P3R A;  1DHF A;  1DHI A;  3RO9 A;  3EEK A;  5HF0 X;  5HSU A;  3OCH A;  4FGG A;  4M6J A;  3F0X X;  4FHB A;  1JOL A;  3SH2 A;  3SR5 X;  1DHJ A;  4HOG A;  1RX5 A;  4KM0 A;  1DAJ A;  1S3V A;  3FYW X;  6DFR A;  1DR4 A;  3R33 A;  5ECC A;  1S3U A;  4H97 A;  3TQ9 A;  3OAF A;  1DYJ A;  4KY8 A;  1RC4 A;  3FRD X;  4XT7 A;  4IXG X;  1VJ3 A;  2W9H A;  1J3I A;  1AI9 A;  4KY4 A;  3JW5 A;  4KBN A;  1CD2 A;  4HA7 A;  3QLW A;  3HBB A;  4Q6A A;  3QL3 A;  3FS6 A;  3SGY A;  1DF7 A;  1RH3 A;  3F0S X;  3F0V X;  4HOE A;  3GHW A;  4PTJ A;  5HSR A;  1SEJ A;  1RE7 A;  1S3W A;  3JWF A;  1HFQ A;  5ECX A;  2ZZA A;  1M78 A;  1RX3 A;  3QYO A;  4IXF X;  4KFJ A;  1U70 A;  1DRE A;  5FDA A;  4KNE A;  2FZI A;  3NTZ A;  3FQF A;  1CZ3 A;  4XT5 A;  1RX1 A;  3K47 A;  4LAE X;  3KJS A;  5HF2 X;  4M6K A;  4I13 A;  2W9T A;  2W9S A;  4LEK X;  5CCC A;  3S7A A;  1J3J A;  3DFR A;  4PST A;  3CSE A;  1DIU A;  1PD8 A;  5HUI A;  1RA8 A;  2ITH A;  3FYV X;  4EIL A;  4M7U A;  2C2S A;  4IXE D;  4KJK A;  4H98 A;  3D84 X;  1J3K A;  4CD2 A;  4NX7 A;  2ANO A;  3NZA X;  2D0K A;  5JG0 X;  4DFR A;  3ROA A;  2W3A A;  3FRE X;  5HT5 A;  3M09 A;  1U71 A;  1LUD A;  4KYA A;  3F0Q X;  1DG7 A;  2FZJ A;  3RG9 A;  1JUV A;  2O7P A;  3IRM A;  1VDR A;  4GH8 A;  4NX6 A;  3FRA X;  4P66 A;  3NU0 A;  3SAI A;  5HQZ A;  3IRO A;  4OR7 A;  4EIZ A;  4DPD A;  3S3V A;  4TU5 X;  1U72 A;  2W3B A;  4EIG A;  3VCO A;  1S3Y A;  3M08 A;  3DG8 A;  4XRB A;  1ZDR A;  3K2H A;  4OSG A;  4KJL A;  1M79 A;  3UM8 A;  4ELH A;  1BZF A;  3DRC A;  4I1N A;  1OHK A;  2JYB A;  3NXO A;  3FQZ A;  4M7V A;  7DFR A;  1JOM A;  2KGK A;  3S9U A;  1RX6 A;  4P68 A;  1MVT A;  2INQ A;  8DFR A;  3NXR A;  1RB2 A;  4LAG X;  2LF1 A;  3CLB A;  4XE6 X;  3TQ8 A;  4EJ1 A;  4Q0E A;  5HPB A;  1DLS A;  5JA3 A;  3F0U X;  4P3Q A;  4PSS A;  4QHV A;  3ZPC A;  2OBC A;  2B3Z A;  3JWC A;  3SA1 A;  4RGC A;  3FRF X;  3QGT A;  3DAU A;  4M2X A;  1KMS A;  2BL9 A;  3GYF A;  5HVB A;  2CIG A;  1RX8 A;  3FQC A;  3NZC X;  5CC9 A;  1RA2 A;  1RD7 A;  2D5N A;  1DYR A;  3FL9 A;  3SRR X;  4QLE A;  5HQY A;  4ECK A;  2DHF A;  3JW3 A;  2ANQ A;  1DRA A;  3LG4 A;  3IA4 A;  4QJC A;  3FQ0 A;  4XT6 A;  3IRN A;  1PD9 A;  1TDR A;  1DDR A;  2W3V A;  1IA2 A;  3SRU X;  5HT4 A;  2BLB A;  1DR2 A;  1DR7 A;  3NRR A; 
#chains in the Genus database with same CATH homology
 5HI6 A;  5HVE A;  4KAK A;  1RA9 A;  3QFX A;  5U26 A;  2AZN A;  3KFY A;  4DPH A;  2HXV A;  2W3W A;  3NXT A;  3JSU A;  3UM6 A;  1IA4 A;  3JTW A;  3NXY A;  1LY4 A;  3INV A;  1HFP A;  5U27 A;  1HFR A;  3CL9 A;  4Q67 A;  4X5J A;  3UM5 A;  3CD2 A;  4ELB A;  2OIP A;  1AOE A;  4X5G A;  3NXX A;  4G8Z X;  1AO8 A;  3K45 A;  4QI9 A;  4QJZ D;  1RG7 A;  3NZD A;  4Q0D A;  4KJJ A;  1RA1 A;  3TQA A;  3EX8 A;  4HA9 A;  3ZPG A;  3NZB X;  4X5F A;  3SRS X;  4KD7 A;  2BLC A;  3F8Y A;  1E26 A;  3FL8 A;  2XW7 A;  3D80 A;  1IA1 A;  2CD2 A;  4QLF A;  3DAT A;  3EEJ A;  3KGY A;  1RA3 A;  1DR5 A;  4G3M A;  1IA3 A;  3N0H A;  5DXV A;  3SA2 A;  4FGH A;  3EEL A;  3TQB A;  2FZH A;  1DR1 A;  1DRF A;  3F0B X;  3GHV A;  4KEB A;  3DL6 A;  1DRH A;  4PDJ A;  3IX9 A;  3QYL A;  4LAH X;  1DG8 A;  3JWM A;  2HQP A;  2G6V A;  1M7A A;  4HOF A;  3FY9 X;  4X5I A;  2L28 A;  1RX9 A;  4QLG A;  1RX7 A;  5E8Q A;  4XEC X;  2HM9 A;  1DR6 A;  2H2Q A;  3QG2 A;  3GHC A;  4ELF A;  2W9G A;  3TD8 A;  3FQV A;  3NZ6 X;  3DGA A;  1DYI A;  1KLK A;  3E0B A;  1KMV A;  1DLR A;  3SRQ X;  1DG5 A;  3QLY A;  4XT4 A;  2W3M A;  1D1G A;  3QL0 A;  1YHO A;  3QLZ A;  4DP3 A;  3F8Z A;  5EAJ A;  1RX4 A;  4PSY A;  3I8A X;  3SQY X;  4M6L A;  1DYH A;  2QK8 A;  2P4G A;  3NZ9 X;  2GD9 A;  3GI2 A;  3Q1H A;  1OHJ A;  3JVX A;  3QLS A;  3JWK A;  4X5H A;  1RX2 A;  2BLA A;  3F91 A;  3KJR A;  1BOZ A;  1DR3 A;  3EIG A;  3I3R A;  1RB3 A;  1DDS A;  4G95 A;  1MVS A;  3IA5 A;  3NXV A;  3KY8 A;  3EEM A;  4KLX A;  4PTH A;  4KL9 A;  1DIS A;  1RF7 A;  3QLR A;  1QZF A;  4DDR A;  4H96 A;  2DRC A;  4ELG A;  4H95 A;  3FQO A;  2C2T A;  1PDB A;  5DFR A;  4ELE A;  4KM2 A;  3DL5 A;  3FY8 X;  4XT8 A;  3SRW X;  3FRB X;  1LY3 A;  3K74 A;  3L3R A;  3QLX A;  1DRB A;  3HJ3 A;  4P3R A;  1DHF A;  1DHI A;  3RO9 A;  3EEK A;  5HF0 X;  5HSU A;  3OCH A;  4FGG A;  4M6J A;  3F0X X;  4FHB A;  1JOL A;  3SH2 A;  3SR5 X;  1DHJ A;  4HOG A;  1RX5 A;  4KM0 A;  1DAJ A;  1S3V A;  3FYW X;  6DFR A;  1DR4 A;  3R33 A;  5ECC A;  1S3U A;  4H97 A;  3TQ9 A;  3OAF A;  1DYJ A;  4KY8 A;  1RC4 A;  3FRD X;  4XT7 A;  4IXG X;  1VJ3 A;  2W9H A;  1J3I A;  1AI9 A;  4KY4 A;  3JW5 A;  4KBN A;  1CD2 A;  4HA7 A;  3QLW A;  3HBB A;  4Q6A A;  3QL3 A;  3FS6 A;  3SGY A;  1DF7 A;  1RH3 A;  3F0S X;  3F0V X;  4HOE A;  3GHW A;  4PTJ A;  5HSR A;  1SEJ A;  1RE7 A;  1S3W A;  3JWF A;  1HFQ A;  5ECX A;  2ZZA A;  1M78 A;  1RX3 A;  3QYO A;  4IXF X;  4KFJ A;  1U70 A;  1DRE A;  5FDA A;  4KNE A;  2FZI A;  3NTZ A;  3FQF A;  1CZ3 A;  4XT5 A;  1RX1 A;  3K47 A;  4LAE X;  3KJS A;  5HF2 X;  4M6K A;  4I13 A;  2W9T A;  2W9S A;  4LEK X;  5CCC A;  3S7A A;  1J3J A;  3DFR A;  4PST A;  3CSE A;  1DIU A;  1PD8 A;  5HUI A;  1RA8 A;  2ITH A;  3FYV X;  4EIL A;  4M7U A;  2C2S A;  4IXE D;  4KJK A;  4H98 A;  3D84 X;  1J3K A;  4CD2 A;  4NX7 A;  2ANO A;  3NZA X;  2D0K A;  5JG0 X;  4DFR A;  3ROA A;  2W3A A;  3FRE X;  5HT5 A;  3M09 A;  1U71 A;  1LUD A;  4KYA A;  3F0Q X;  1DG7 A;  2FZJ A;  3RG9 A;  1JUV A;  2O7P A;  3IRM A;  1VDR A;  4GH8 A;  4NX6 A;  3FRA X;  4P66 A;  3NU0 A;  3SAI A;  5HQZ A;  3IRO A;  4OR7 A;  4EIZ A;  4DPD A;  3S3V A;  4TU5 X;  1U72 A;  2W3B A;  4EIG A;  3VCO A;  1S3Y A;  3M08 A;  3DG8 A;  4XRB A;  1ZDR A;  3K2H A;  4OSG A;  4KJL A;  1M79 A;  3UM8 A;  4ELH A;  1BZF A;  3DRC A;  4I1N A;  1OHK A;  2JYB A;  3NXO A;  3FQZ A;  4M7V A;  7DFR A;  1JOM A;  2KGK A;  3S9U A;  1RX6 A;  4P68 A;  1MVT A;  2INQ A;  8DFR A;  3NXR A;  1RB2 A;  4LAG X;  2LF1 A;  3CLB A;  4XE6 X;  3TQ8 A;  4EJ1 A;  4Q0E A;  5HPB A;  1DLS A;  5JA3 A;  3F0U X;  4P3Q A;  4PSS A;  4QHV A;  3ZPC A;  2OBC A;  2B3Z A;  3JWC A;  3SA1 A;  4RGC A;  3FRF X;  3QGT A;  3DAU A;  4M2X A;  1KMS A;  2BL9 A;  3GYF A;  5HVB A;  2CIG A;  1RX8 A;  3FQC A;  3NZC X;  5CC9 A;  1RA2 A;  1RD7 A;  2D5N A;  1DYR A;  3FL9 A;  3SRR X;  4QLE A;  5HQY A;  4ECK A;  2DHF A;  3JW3 A;  2ANQ A;  1DRA A;  3LG4 A;  3IA4 A;  4QJC A;  3FQ0 A;  4XT6 A;  3IRN A;  1PD9 A;  1TDR A;  1DDR A;  2W3V A;  1IA2 A;  3SRU X;  5HT4 A;  2BLB A;  1DR2 A;  1DR7 A;  3NRR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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