3NXYA

Preferential selection of isomer binding from chiral mixtures: alernate binding modes observed fro the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 53
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2010-07-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3nxyA00
3NZ6X 1DF7A 4ELEA 2HM9A 3SH2A 3QYOA 1DLSA 1IA1A 1E26A 3K74A 3GHWA 4X5GA 4ELBA 1DREA 4KL9A 1AI9A 3FRBX 4KLXA 4KJLA 1M78A 4KM2A 1RA2A 3D84X 1BZFA 2H2QA 3QLRA 5EAJA 1JUVA 3IX9A 2BL9A 3K45A 2CD2A 3EEKA 2INQA 3SQYX 2OBCA 4HOGA 3UM6A 4EILA 1HFRA 4XRBA 5HSRA 1ZDRA 1DRHA 1RX3A 5HQYA 3FY8X 1PDBA 1DR2A 3JVXA 4FGGA 4HOFA 1SEJA 1DRBA 1RX7A 4LEKX 3KJSA 3S3VA 4IXED 4X5HA 3FQVA 3KJRA 4M7UA 4KJJA 3TQ8A 4DDRA 1U70A 4G8ZX 4HOEA 1DLRA 5JA3A 1PD9A 4X5JA 2W3AA 1DISA 3M08A 3FQ0A 4KEBA 1OHJA 2W9TA 3NZBX 4OR7A 4XECX 3L3RA 2KGKA 3NZDA 2DHFA 4ELHA 3F8ZA 4PSTA 4RGCA 4KJKA 4DFRA 4XT4A 3KFYA 1KLKA 2W9SA 3FL9A 1S3WA 4XE6X 4XT5A 3SGYA 2P4GA 3EIGA 3FY9X 2B3ZA 2BLBA 1RC4A 3QLWA 4QJZD 1DDRA 1DYJA 3FRFX 1RA3A 1IA3A 1DR7A 1RA9A 1DDSA 1DR3A 4X5FA 3QGTA 4M6JA 3FYWX 4H97A 3DFRA 3SRWX 2W9HA 3EX8A 3IRMA 3IA4A 4PDJA 1M7AA 3JWFA 1U71A 1DR6A 3K47A 2XW7A 2BLCA 3NZCX 3Q1HA 3ROAA 3NXVA 3SRQX 2FZIA 4ELFA 3FREX 4XT7A 4P66A 3RO9A 3QLXA 4TU5X 1DHFA 1DYHA 5HSUA 4OSGA 3DAUA 4QJCA 3F0SX 3DGAA 4KYAA 4KAKA 1RF7A 4HA9A 3JTWA 5CCCA 3EEMA 3ZPCA 2ZZAA 5JG0X 1U72A 5HT5A 2FZJA 1AOEA 1KMVA 3SA1A 1S3UA 1DG5A 3NXRA 3CD2A 2AZNA 5DFRA 4EIGA 3I3RA 3D80A 3DL6A 4XT8A 3QFXA 1DRFA 2C2TA 2D5NA 1HFPA 3QYLA 1RX9A 3SA2A 2QK8A 2GD9A 3FQOA 1JOLA 1M79A 5U26A 4PSYA 1RH3A 3FL8A 3INVA 1AO8A 4HA7A 1D1GA 1RX4A 3KGYA 1CZ3A 1YHOA 3LG4A 3S9UA 1RB3A 1LUDA 1DRAA 3F0VX 1TDRA 2W3MA 4KM0A 3IA5A 3JWMA 5FDAA 4M6LA 4LAEX 1RB2A 5HF2X 4ECKA 3CSEA 3TQAA 3NXOA 1DIUA 4GH8A 4M7VA 3FRAX 4FHBA 2ANQA 3K2HA 3TD8A 3NXXA 2D0KA 2JYBA 4H95A 1RX6A 3JSUA 4IXGX 5HQZA 3GI2A 1J3KA 5CC9A 5HT4A 3CL9A 5ECXA 3OCHA 3IRNA 3F0UX 3NXTA 3F0XX 1J3JA 1RX8A 2BLAA 2HQPA 2W9GA 4G3MA 3DL5A 4Q0DA 1S3VA 3FS6A 1HFQA 4M6KA 1IA4A 1LY3A 3NTZA 6DFRA 3M09A 3GHVA 5E8QA 4FGHA 1DG8A 4EJ1A 4ELGA 1BOZA 3HBBA 4KBNA 5HI6A 3QLYA 1DG7A 1S3YA 3NZ9X 4KNEA 4QLEA 1RX2A 3I8AX 3SR5X 5DXVA 3DATA 2HXVA 5HF0X 4EIZA 3KY8A 3FQZA 2W3WA 1RA8A 4QHVA 3F91A 4XT6A 1MVTA 1DR1A 3QL0A 2G6VA 1QZFA 2FZHA 1RG7A 2O7PA 4KY4A 3QLZA 1MVSA 3JW3A 1JOMA 4NX6A 3NU0A 3R33A 3NZAX 2OIPA 3N0HA 4DPHA 4P68A 4X5IA 3QG2A 2CIGA 2W3VA 3FQCA 2C2SA 5HVBA 5HUIA 4I1NA 3FQFA 4KY8A 1RX1A 3OAFA 1CD2A 3TQ9A 3SRSX 1LY4A 3QLSA 3SRUX 4DP3A 1DYIA 4DPDA 3ZPGA 4Q6AA 3FRDX 5HPBA 1OHKA 1IA2A 3GHCA 4KFJA 4IXFX 3F0BX 3F0QX 3JWCA 1DR5A 4NX7A 4I13A 1J3IA 1VJ3A 8DFRA 1RD7A 1DHIA 2ITHA 4QLGA 2ANOA 3EELA 4LAHX 4G95A 1DAJA 5ECCA 2W3BA 3TQBA 3SAIA 3EEJA 3DRCA 3QL3A 4Q67A 1RA1A 3SRRX 3NXYA 1VDRA 5HVEA 3GYFA 3IROA 4M2XA 4Q0EA 3UM8A 1RE7A 1DHJA 3UM5A 4KD7A 1RX5A 4P3QA 4H96A 3HJ3A 4LAGX 3VCOA 2L28A 1DR4A 3NRRA 4CD2A 3S7AA 3E0BA 3F8YA 5U27A 3JWKA 3DG8A 4H98A 3CLBA 2DRCA 2LF1A 4PSSA 1DYRA 1PD8A 3RG9A 4PTHA 1KMSA 4PTJA 4QLFA 3FYVX 4P3RA 3JW5A 4QI9A 7DFRA
chains in the Genus database with same CATH superfamily
3NZ6X 1DF7A 4ELEA 2HM9A 3SH2A 3QYOA 1DLSA 1IA1A 1E26A 3K74A 3GHWA 4X5GA 4ELBA 1DREA 4KL9A 1AI9A 3FRBX 4KLXA 4KJLA 1M78A 4KM2A 1RA2A 3D84X 1BZFA 2H2QA 3QLRA 5EAJA 1JUVA 3IX9A 2BL9A 3K45A 2CD2A 3EEKA 2INQA 3SQYX 2OBCA 4HOGA 3UM6A 4EILA 1HFRA 4XRBA 5HSRA 1ZDRA 1DRHA 1RX3A 5HQYA 3FY8X 1PDBA 1DR2A 3JVXA 4FGGA 4HOFA 1SEJA 1DRBA 1RX7A 4LEKX 3KJSA 3S3VA 4IXED 4X5HA 3FQVA 3KJRA 4M7UA 4KJJA 3TQ8A 4DDRA 1U70A 4G8ZX 4HOEA 1DLRA 5JA3A 1PD9A 4X5JA 2W3AA 1DISA 3M08A 3FQ0A 4KEBA 1OHJA 2W9TA 3NZBX 4OR7A 4XECX 3L3RA 2KGKA 3NZDA 2DHFA 4ELHA 3F8ZA 4PSTA 4RGCA 4KJKA 4DFRA 4XT4A 3KFYA 1KLKA 2W9SA 3FL9A 1S3WA 4XE6X 4XT5A 3SGYA 2P4GA 3EIGA 3FY9X 2B3ZA 2BLBA 1RC4A 3QLWA 4QJZD 1DDRA 1DYJA 3FRFX 1RA3A 1IA3A 1DR7A 1RA9A 1DDSA 1DR3A 4X5FA 3QGTA 4M6JA 3FYWX 4H97A 3DFRA 3SRWX 2W9HA 3EX8A 3IRMA 3IA4A 4PDJA 1M7AA 3JWFA 1U71A 1DR6A 3K47A 2XW7A 2BLCA 3NZCX 3Q1HA 3ROAA 3NXVA 3SRQX 2FZIA 4ELFA 3FREX 4XT7A 4P66A 3RO9A 3QLXA 4TU5X 1DHFA 1DYHA 5HSUA 4OSGA 3DAUA 4QJCA 3F0SX 3DGAA 4KYAA 4KAKA 1RF7A 4HA9A 3JTWA 5CCCA 3EEMA 3ZPCA 2ZZAA 5JG0X 1U72A 5HT5A 2FZJA 1AOEA 1KMVA 3SA1A 1S3UA 1DG5A 3NXRA 3CD2A 2AZNA 5DFRA 4EIGA 3I3RA 3D80A 3DL6A 4XT8A 3QFXA 1DRFA 2C2TA 2D5NA 1HFPA 3QYLA 1RX9A 3SA2A 2QK8A 2GD9A 3FQOA 1JOLA 1M79A 5U26A 4PSYA 1RH3A 3FL8A 3INVA 1AO8A 4HA7A 1D1GA 1RX4A 3KGYA 1CZ3A 1YHOA 3LG4A 3S9UA 1RB3A 1LUDA 1DRAA 3F0VX 1TDRA 2W3MA 4KM0A 3IA5A 3JWMA 5FDAA 4M6LA 4LAEX 1RB2A 5HF2X 4ECKA 3CSEA 3TQAA 3NXOA 1DIUA 4GH8A 4M7VA 3FRAX 4FHBA 2ANQA 3K2HA 3TD8A 3NXXA 2D0KA 2JYBA 4H95A 1RX6A 3JSUA 4IXGX 5HQZA 3GI2A 1J3KA 5CC9A 5HT4A 3CL9A 5ECXA 3OCHA 3IRNA 3F0UX 3NXTA 3F0XX 1J3JA 1RX8A 2BLAA 2HQPA 2W9GA 4G3MA 3DL5A 4Q0DA 1S3VA 3FS6A 1HFQA 4M6KA 1IA4A 1LY3A 3NTZA 6DFRA 3M09A 3GHVA 5E8QA 4FGHA 1DG8A 4EJ1A 4ELGA 1BOZA 3HBBA 4KBNA 5HI6A 3QLYA 1DG7A 1S3YA 3NZ9X 4KNEA 4QLEA 1RX2A 3I8AX 3SR5X 5DXVA 3DATA 2HXVA 5HF0X 4EIZA 3KY8A 3FQZA 2W3WA 1RA8A 4QHVA 3F91A 4XT6A 1MVTA 1DR1A 3QL0A 2G6VA 1QZFA 2FZHA 1RG7A 2O7PA 4KY4A 3QLZA 1MVSA 3JW3A 1JOMA 4NX6A 3NU0A 3R33A 3NZAX 2OIPA 3N0HA 4DPHA 4P68A 4X5IA 3QG2A 2CIGA 2W3VA 3FQCA 2C2SA 5HVBA 5HUIA 4I1NA 3FQFA 4KY8A 1RX1A 3OAFA 1CD2A 3TQ9A 3SRSX 1LY4A 3QLSA 3SRUX 4DP3A 1DYIA 4DPDA 3ZPGA 4Q6AA 3FRDX 5HPBA 1OHKA 1IA2A 3GHCA 4KFJA 4IXFX 3F0BX 3F0QX 3JWCA 1DR5A 4NX7A 4I13A 1J3IA 1VJ3A 8DFRA 1RD7A 1DHIA 2ITHA 4QLGA 2ANOA 3EELA 4LAHX 4G95A 1DAJA 5ECCA 2W3BA 3TQBA 3SAIA 3EEJA 3DRCA 3QL3A 4Q67A 1RA1A 3SRRX 3NXYA 1VDRA 5HVEA 3GYFA 3IROA 4M2XA 4Q0EA 3UM8A 1RE7A 1DHJA 3UM5A 4KD7A 1RX5A 4P3QA 4H96A 3HJ3A 4LAGX 3VCOA 2L28A 1DR4A 3NRRA 4CD2A 3S7AA 3E0BA 3F8YA 5U27A 3JWKA 3DG8A 4H98A 3CLBA 2DRCA 2LF1A 4PSSA 1DYRA 1PD8A 3RG9A 4PTHA 1KMSA 4PTJA 4QLFA 3FYVX 4P3RA 3JW5A 4QI9A 7DFRA
chains in the Genus database with same CATH topology
3NZ6X 1DF7A 4ELEA 2HM9A 3SH2A 3QYOA 1DLSA 1IA1A 1E26A 3K74A 3GHWA 4X5GA 4ELBA 1DREA 4KL9A 1AI9A 3FRBX 4KLXA 4KJLA 1M78A 4KM2A 1RA2A 3D84X 1BZFA 2H2QA 3QLRA 5EAJA 1JUVA 3IX9A 2BL9A 3K45A 2CD2A 3EEKA 2INQA 3SQYX 2OBCA 4HOGA 3UM6A 4EILA 1HFRA 4XRBA 5HSRA 1ZDRA 1DRHA 1RX3A 5HQYA 3FY8X 1PDBA 1DR2A 3JVXA 4FGGA 4HOFA 1SEJA 1DRBA 1RX7A 4LEKX 3KJSA 3S3VA 4IXED 4X5HA 3FQVA 3KJRA 4M7UA 4KJJA 3TQ8A 4DDRA 1U70A 4G8ZX 4HOEA 1DLRA 5JA3A 1PD9A 4X5JA 2W3AA 1DISA 3M08A 3FQ0A 4KEBA 1OHJA 2W9TA 3NZBX 4OR7A 4XECX 3L3RA 2KGKA 3NZDA 2DHFA 4ELHA 3F8ZA 4PSTA 4RGCA 4KJKA 4DFRA 4XT4A 3KFYA 1KLKA 2W9SA 3FL9A 1S3WA 4XE6X 4XT5A 3SGYA 2P4GA 3EIGA 3FY9X 2B3ZA 2BLBA 1RC4A 3QLWA 4QJZD 1DDRA 1DYJA 3FRFX 1RA3A 1IA3A 1DR7A 1RA9A 1DDSA 1DR3A 4X5FA 3QGTA 4M6JA 3FYWX 4H97A 3DFRA 3SRWX 2W9HA 3EX8A 3IRMA 3IA4A 4PDJA 1M7AA 3JWFA 1U71A 1DR6A 3K47A 2XW7A 2BLCA 3NZCX 3Q1HA 3ROAA 3NXVA 3SRQX 2FZIA 4ELFA 3FREX 4XT7A 4P66A 3RO9A 3QLXA 4TU5X 1DHFA 1DYHA 5HSUA 4OSGA 3DAUA 4QJCA 3F0SX 3DGAA 4KYAA 4KAKA 1RF7A 4HA9A 3JTWA 5CCCA 3EEMA 3ZPCA 2ZZAA 5JG0X 1U72A 5HT5A 2FZJA 1AOEA 1KMVA 3SA1A 1S3UA 1DG5A 3NXRA 3CD2A 2AZNA 5DFRA 4EIGA 3I3RA 3D80A 3DL6A 4XT8A 3QFXA 1DRFA 2C2TA 2D5NA 1HFPA 3QYLA 1RX9A 3SA2A 2QK8A 2GD9A 3FQOA 1JOLA 1M79A 5U26A 4PSYA 1RH3A 3FL8A 3INVA 1AO8A 4HA7A 1D1GA 1RX4A 3KGYA 1CZ3A 1YHOA 3LG4A 3S9UA 1RB3A 1LUDA 1DRAA 3F0VX 1TDRA 2W3MA 4KM0A 3IA5A 3JWMA 5FDAA 4M6LA 4LAEX 1RB2A 5HF2X 4ECKA 3CSEA 3TQAA 3NXOA 1DIUA 4GH8A 4M7VA 3FRAX 4FHBA 2ANQA 3K2HA 3TD8A 3NXXA 2D0KA 2JYBA 4H95A 1RX6A 3JSUA 4IXGX 5HQZA 3GI2A 1J3KA 5CC9A 5HT4A 3CL9A 5ECXA 3OCHA 3IRNA 3F0UX 3NXTA 3F0XX 1J3JA 1RX8A 2BLAA 2HQPA 2W9GA 4G3MA 3DL5A 4Q0DA 1S3VA 3FS6A 1HFQA 4M6KA 1IA4A 1LY3A 3NTZA 6DFRA 3M09A 3GHVA 5E8QA 4FGHA 1DG8A 4EJ1A 4ELGA 1BOZA 3HBBA 4KBNA 5HI6A 3QLYA 1DG7A 1S3YA 3NZ9X 4KNEA 4QLEA 1RX2A 3I8AX 3SR5X 5DXVA 3DATA 2HXVA 5HF0X 4EIZA 3KY8A 3FQZA 2W3WA 1RA8A 4QHVA 3F91A 4XT6A 1MVTA 1DR1A 3QL0A 2G6VA 1QZFA 2FZHA 1RG7A 2O7PA 4KY4A 3QLZA 1MVSA 3JW3A 1JOMA 4NX6A 3NU0A 3R33A 3NZAX 2OIPA 3N0HA 4DPHA 4P68A 4X5IA 3QG2A 2CIGA 2W3VA 3FQCA 2C2SA 5HVBA 5HUIA 4I1NA 3FQFA 4KY8A 1RX1A 3OAFA 1CD2A 3TQ9A 3SRSX 1LY4A 3QLSA 3SRUX 4DP3A 1DYIA 4DPDA 3ZPGA 4Q6AA 3FRDX 5HPBA 1OHKA 1IA2A 3GHCA 4KFJA 4IXFX 3F0BX 3F0QX 3JWCA 1DR5A 4NX7A 4I13A 1J3IA 1VJ3A 8DFRA 1RD7A 1DHIA 2ITHA 4QLGA 2ANOA 3EELA 4LAHX 4G95A 1DAJA 5ECCA 2W3BA 3TQBA 3SAIA 3EEJA 3DRCA 3QL3A 4Q67A 1RA1A 3SRRX 3NXYA 1VDRA 5HVEA 3GYFA 3IROA 4M2XA 4Q0EA 3UM8A 1RE7A 1DHJA 3UM5A 4KD7A 1RX5A 4P3QA 4H96A 3HJ3A 4LAGX 3VCOA 2L28A 1DR4A 3NRRA 4CD2A 3S7AA 3E0BA 3F8YA 5U27A 3JWKA 3DG8A 4H98A 3CLBA 2DRCA 2LF1A 4PSSA 1DYRA 1PD8A 3RG9A 4PTHA 1KMSA 4PTJA 4QLFA 3FYVX 4P3RA 3JW5A 4QI9A 7DFRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NZ6 X;  1DF7 A;  4ELE A;  2HM9 A;  3SH2 A;  3QYO A;  1DLS A;  1IA1 A;  1E26 A;  3K74 A;  3GHW A;  4X5G A;  4ELB A;  1DRE A;  4KL9 A;  1AI9 A;  3FRB X;  4KLX A;  4KJL A;  1M78 A;  4KM2 A;  1RA2 A;  3D84 X;  1BZF A;  2H2Q A;  3QLR A;  5EAJ A;  1JUV A;  3IX9 A;  2BL9 A;  3K45 A;  2CD2 A;  3EEK A;  2INQ A;  3SQY X;  2OBC A;  4HOG A;  3UM6 A;  4EIL A;  1HFR A;  4XRB A;  5HSR A;  1ZDR A;  1DRH A;  1RX3 A;  5HQY A;  3FY8 X;  1PDB A;  1DR2 A;  3JVX A;  4FGG A;  4HOF A;  1SEJ A;  1DRB A;  1RX7 A;  4LEK X;  3KJS A;  3S3V A;  4IXE D;  4X5H A;  3FQV A;  3KJR A;  4M7U A;  4KJJ A;  3TQ8 A;  4DDR A;  1U70 A;  4G8Z X;  4HOE A;  1DLR A;  5JA3 A;  1PD9 A;  4X5J A;  2W3A A;  1DIS A;  3M08 A;  3FQ0 A;  4KEB A;  1OHJ A;  2W9T A;  3NZB X;  4OR7 A;  4XEC X;  3L3R A;  2KGK A;  3NZD A;  2DHF A;  4ELH A;  3F8Z A;  4PST A;  4RGC A;  4KJK A;  4DFR A;  4XT4 A;  3KFY A;  1KLK A;  2W9S A;  3FL9 A;  1S3W A;  4XE6 X;  4XT5 A;  3SGY A;  2P4G A;  3EIG A;  3FY9 X;  2B3Z A;  2BLB A;  1RC4 A;  3QLW A;  4QJZ D;  1DDR A;  1DYJ A;  3FRF X;  1RA3 A;  1IA3 A;  1DR7 A;  1RA9 A;  1DDS A;  1DR3 A;  4X5F A;  3QGT A;  4M6J A;  3FYW X;  4H97 A;  3DFR A;  3SRW X;  2W9H A;  3EX8 A;  3IRM A;  3IA4 A;  4PDJ A;  1M7A A;  3JWF A;  1U71 A;  1DR6 A;  3K47 A;  2XW7 A;  2BLC A;  3NZC X;  3Q1H A;  3ROA A;  3NXV A;  3SRQ X;  2FZI A;  4ELF A;  3FRE X;  4XT7 A;  4P66 A;  3RO9 A;  3QLX A;  4TU5 X;  1DHF A;  1DYH A;  5HSU A;  4OSG A;  3DAU A;  4QJC A;  3F0S X;  3DGA A;  4KYA A;  4KAK A;  1RF7 A;  4HA9 A;  3JTW A;  5CCC A;  3EEM A;  3ZPC A;  2ZZA A;  5JG0 X;  1U72 A;  5HT5 A;  2FZJ A;  1AOE A;  1KMV A;  3SA1 A;  1S3U A;  1DG5 A;  3NXR A;  3CD2 A;  2AZN A;  5DFR A;  4EIG A;  3I3R A;  3D80 A;  3DL6 A;  4XT8 A;  3QFX A;  1DRF A;  2C2T A;  2D5N A;  1HFP A;  3QYL A;  1RX9 A;  3SA2 A;  2QK8 A;  2GD9 A;  3FQO A;  1JOL A;  1M79 A;  5U26 A;  4PSY A;  1RH3 A;  3FL8 A;  3INV A;  1AO8 A;  4HA7 A;  1D1G A;  1RX4 A;  3KGY A;  1CZ3 A;  1YHO A;  3LG4 A;  3S9U A;  1RB3 A;  1LUD A;  1DRA A;  3F0V X;  1TDR A;  2W3M A;  4KM0 A;  3IA5 A;  3JWM A;  5FDA A;  4M6L A;  4LAE X;  1RB2 A;  5HF2 X;  4ECK A;  3CSE A;  3TQA A;  3NXO A;  1DIU A;  4GH8 A;  4M7V A;  3FRA X;  4FHB A;  2ANQ A;  3K2H A;  3TD8 A;  3NXX A;  2D0K A;  2JYB A;  4H95 A;  1RX6 A;  3JSU A;  4IXG X;  5HQZ A;  3GI2 A;  1J3K A;  5CC9 A;  5HT4 A;  3CL9 A;  5ECX A;  3OCH A;  3IRN A;  3F0U X;  3NXT A;  3F0X X;  1J3J A;  1RX8 A;  2BLA A;  2HQP A;  2W9G A;  4G3M A;  3DL5 A;  4Q0D A;  1S3V A;  3FS6 A;  1HFQ A;  4M6K A;  1IA4 A;  1LY3 A;  3NTZ A;  6DFR A;  3M09 A;  3GHV A;  5E8Q A;  4FGH A;  1DG8 A;  4EJ1 A;  4ELG A;  1BOZ A;  3HBB A;  4KBN A;  5HI6 A;  3QLY A;  1DG7 A;  1S3Y A;  3NZ9 X;  4KNE A;  4QLE A;  1RX2 A;  3I8A X;  3SR5 X;  5DXV A;  3DAT A;  2HXV A;  5HF0 X;  4EIZ A;  3KY8 A;  3FQZ A;  2W3W A;  1RA8 A;  4QHV A;  3F91 A;  4XT6 A;  1MVT A;  1DR1 A;  3QL0 A;  2G6V A;  1QZF A;  2FZH A;  1RG7 A;  2O7P A;  4KY4 A;  3QLZ A;  1MVS A;  3JW3 A;  1JOM A;  4NX6 A;  3NU0 A;  3R33 A;  3NZA X;  2OIP A;  3N0H A;  4DPH A;  4P68 A;  4X5I A;  3QG2 A;  2CIG A;  2W3V A;  3FQC A;  2C2S A;  5HVB A;  5HUI A;  4I1N A;  3FQF A;  4KY8 A;  1RX1 A;  3OAF A;  1CD2 A;  3TQ9 A;  3SRS X;  1LY4 A;  3QLS A;  3SRU X;  4DP3 A;  1DYI A;  4DPD A;  3ZPG A;  4Q6A A;  3FRD X;  5HPB A;  1OHK A;  1IA2 A;  3GHC A;  4KFJ A;  4IXF X;  3F0B X;  3F0Q X;  3JWC A;  1DR5 A;  4NX7 A;  4I13 A;  1J3I A;  1VJ3 A;  8DFR A;  1RD7 A;  1DHI A;  2ITH A;  4QLG A;  2ANO A;  3EEL A;  4LAH X;  4G95 A;  1DAJ A;  5ECC A;  2W3B A;  3TQB A;  3SAI A;  3EEJ A;  3DRC A;  3QL3 A;  4Q67 A;  1RA1 A;  3SRR X;  3NXY A;  1VDR A;  5HVE A;  3GYF A;  3IRO A;  4M2X A;  4Q0E A;  3UM8 A;  1RE7 A;  1DHJ A;  3UM5 A;  4KD7 A;  1RX5 A;  4P3Q A;  4H96 A;  3HJ3 A;  4LAG X;  3VCO A;  2L28 A;  1DR4 A;  3NRR A;  4CD2 A;  3S7A A;  3E0B A;  3F8Y A;  5U27 A;  3JWK A;  3DG8 A;  4H98 A;  3CLB A;  2DRC A;  2LF1 A;  4PSS A;  1DYR A;  1PD8 A;  3RG9 A;  4PTH A;  1KMS A;  4PTJ A;  4QLF A;  3FYV X;  4P3R A;  3JW5 A;  4QI9 A;  7DFR A; 
#chains in the Genus database with same CATH topology
 3NZ6 X;  1DF7 A;  4ELE A;  2HM9 A;  3SH2 A;  3QYO A;  1DLS A;  1IA1 A;  1E26 A;  3K74 A;  3GHW A;  4X5G A;  4ELB A;  1DRE A;  4KL9 A;  1AI9 A;  3FRB X;  4KLX A;  4KJL A;  1M78 A;  4KM2 A;  1RA2 A;  3D84 X;  1BZF A;  2H2Q A;  3QLR A;  5EAJ A;  1JUV A;  3IX9 A;  2BL9 A;  3K45 A;  2CD2 A;  3EEK A;  2INQ A;  3SQY X;  2OBC A;  4HOG A;  3UM6 A;  4EIL A;  1HFR A;  4XRB A;  5HSR A;  1ZDR A;  1DRH A;  1RX3 A;  5HQY A;  3FY8 X;  1PDB A;  1DR2 A;  3JVX A;  4FGG A;  4HOF A;  1SEJ A;  1DRB A;  1RX7 A;  4LEK X;  3KJS A;  3S3V A;  4IXE D;  4X5H A;  3FQV A;  3KJR A;  4M7U A;  4KJJ A;  3TQ8 A;  4DDR A;  1U70 A;  4G8Z X;  4HOE A;  1DLR A;  5JA3 A;  1PD9 A;  4X5J A;  2W3A A;  1DIS A;  3M08 A;  3FQ0 A;  4KEB A;  1OHJ A;  2W9T A;  3NZB X;  4OR7 A;  4XEC X;  3L3R A;  2KGK A;  3NZD A;  2DHF A;  4ELH A;  3F8Z A;  4PST A;  4RGC A;  4KJK A;  4DFR A;  4XT4 A;  3KFY A;  1KLK A;  2W9S A;  3FL9 A;  1S3W A;  4XE6 X;  4XT5 A;  3SGY A;  2P4G A;  3EIG A;  3FY9 X;  2B3Z A;  2BLB A;  1RC4 A;  3QLW A;  4QJZ D;  1DDR A;  1DYJ A;  3FRF X;  1RA3 A;  1IA3 A;  1DR7 A;  1RA9 A;  1DDS A;  1DR3 A;  4X5F A;  3QGT A;  4M6J A;  3FYW X;  4H97 A;  3DFR A;  3SRW X;  2W9H A;  3EX8 A;  3IRM A;  3IA4 A;  4PDJ A;  1M7A A;  3JWF A;  1U71 A;  1DR6 A;  3K47 A;  2XW7 A;  2BLC A;  3NZC X;  3Q1H A;  3ROA A;  3NXV A;  3SRQ X;  2FZI A;  4ELF A;  3FRE X;  4XT7 A;  4P66 A;  3RO9 A;  3QLX A;  4TU5 X;  1DHF A;  1DYH A;  5HSU A;  4OSG A;  3DAU A;  4QJC A;  3F0S X;  3DGA A;  4KYA A;  4KAK A;  1RF7 A;  4HA9 A;  3JTW A;  5CCC A;  3EEM A;  3ZPC A;  2ZZA A;  5JG0 X;  1U72 A;  5HT5 A;  2FZJ A;  1AOE A;  1KMV A;  3SA1 A;  1S3U A;  1DG5 A;  3NXR A;  3CD2 A;  2AZN A;  5DFR A;  4EIG A;  3I3R A;  3D80 A;  3DL6 A;  4XT8 A;  3QFX A;  1DRF A;  2C2T A;  2D5N A;  1HFP A;  3QYL A;  1RX9 A;  3SA2 A;  2QK8 A;  2GD9 A;  3FQO A;  1JOL A;  1M79 A;  5U26 A;  4PSY A;  1RH3 A;  3FL8 A;  3INV A;  1AO8 A;  4HA7 A;  1D1G A;  1RX4 A;  3KGY A;  1CZ3 A;  1YHO A;  3LG4 A;  3S9U A;  1RB3 A;  1LUD A;  1DRA A;  3F0V X;  1TDR A;  2W3M A;  4KM0 A;  3IA5 A;  3JWM A;  5FDA A;  4M6L A;  4LAE X;  1RB2 A;  5HF2 X;  4ECK A;  3CSE A;  3TQA A;  3NXO A;  1DIU A;  4GH8 A;  4M7V A;  3FRA X;  4FHB A;  2ANQ A;  3K2H A;  3TD8 A;  3NXX A;  2D0K A;  2JYB A;  4H95 A;  1RX6 A;  3JSU A;  4IXG X;  5HQZ A;  3GI2 A;  1J3K A;  5CC9 A;  5HT4 A;  3CL9 A;  5ECX A;  3OCH A;  3IRN A;  3F0U X;  3NXT A;  3F0X X;  1J3J A;  1RX8 A;  2BLA A;  2HQP A;  2W9G A;  4G3M A;  3DL5 A;  4Q0D A;  1S3V A;  3FS6 A;  1HFQ A;  4M6K A;  1IA4 A;  1LY3 A;  3NTZ A;  6DFR A;  3M09 A;  3GHV A;  5E8Q A;  4FGH A;  1DG8 A;  4EJ1 A;  4ELG A;  1BOZ A;  3HBB A;  4KBN A;  5HI6 A;  3QLY A;  1DG7 A;  1S3Y A;  3NZ9 X;  4KNE A;  4QLE A;  1RX2 A;  3I8A X;  3SR5 X;  5DXV A;  3DAT A;  2HXV A;  5HF0 X;  4EIZ A;  3KY8 A;  3FQZ A;  2W3W A;  1RA8 A;  4QHV A;  3F91 A;  4XT6 A;  1MVT A;  1DR1 A;  3QL0 A;  2G6V A;  1QZF A;  2FZH A;  1RG7 A;  2O7P A;  4KY4 A;  3QLZ A;  1MVS A;  3JW3 A;  1JOM A;  4NX6 A;  3NU0 A;  3R33 A;  3NZA X;  2OIP A;  3N0H A;  4DPH A;  4P68 A;  4X5I A;  3QG2 A;  2CIG A;  2W3V A;  3FQC A;  2C2S A;  5HVB A;  5HUI A;  4I1N A;  3FQF A;  4KY8 A;  1RX1 A;  3OAF A;  1CD2 A;  3TQ9 A;  3SRS X;  1LY4 A;  3QLS A;  3SRU X;  4DP3 A;  1DYI A;  4DPD A;  3ZPG A;  4Q6A A;  3FRD X;  5HPB A;  1OHK A;  1IA2 A;  3GHC A;  4KFJ A;  4IXF X;  3F0B X;  3F0Q X;  3JWC A;  1DR5 A;  4NX7 A;  4I13 A;  1J3I A;  1VJ3 A;  8DFR A;  1RD7 A;  1DHI A;  2ITH A;  4QLG A;  2ANO A;  3EEL A;  4LAH X;  4G95 A;  1DAJ A;  5ECC A;  2W3B A;  3TQB A;  3SAI A;  3EEJ A;  3DRC A;  3QL3 A;  4Q67 A;  1RA1 A;  3SRR X;  3NXY A;  1VDR A;  5HVE A;  3GYF A;  3IRO A;  4M2X A;  4Q0E A;  3UM8 A;  1RE7 A;  1DHJ A;  3UM5 A;  4KD7 A;  1RX5 A;  4P3Q A;  4H96 A;  3HJ3 A;  4LAG X;  3VCO A;  2L28 A;  1DR4 A;  3NRR A;  4CD2 A;  3S7A A;  3E0B A;  3F8Y A;  5U27 A;  3JWK A;  3DG8 A;  4H98 A;  3CLB A;  2DRC A;  2LF1 A;  4PSS A;  1DYR A;  1PD8 A;  3RG9 A;  4PTH A;  1KMS A;  4PTJ A;  4QLF A;  3FYV X;  4P3R A;  3JW5 A;  4QI9 A;  7DFR A; 
#chains in the Genus database with same CATH homology
 3NZ6 X;  1DF7 A;  4ELE A;  2HM9 A;  3SH2 A;  3QYO A;  1DLS A;  1IA1 A;  1E26 A;  3K74 A;  3GHW A;  4X5G A;  4ELB A;  1DRE A;  4KL9 A;  1AI9 A;  3FRB X;  4KLX A;  4KJL A;  1M78 A;  4KM2 A;  1RA2 A;  3D84 X;  1BZF A;  2H2Q A;  3QLR A;  5EAJ A;  1JUV A;  3IX9 A;  2BL9 A;  3K45 A;  2CD2 A;  3EEK A;  2INQ A;  3SQY X;  2OBC A;  4HOG A;  3UM6 A;  4EIL A;  1HFR A;  4XRB A;  5HSR A;  1ZDR A;  1DRH A;  1RX3 A;  5HQY A;  3FY8 X;  1PDB A;  1DR2 A;  3JVX A;  4FGG A;  4HOF A;  1SEJ A;  1DRB A;  1RX7 A;  4LEK X;  3KJS A;  3S3V A;  4IXE D;  4X5H A;  3FQV A;  3KJR A;  4M7U A;  4KJJ A;  3TQ8 A;  4DDR A;  1U70 A;  4G8Z X;  4HOE A;  1DLR A;  5JA3 A;  1PD9 A;  4X5J A;  2W3A A;  1DIS A;  3M08 A;  3FQ0 A;  4KEB A;  1OHJ A;  2W9T A;  3NZB X;  4OR7 A;  4XEC X;  3L3R A;  2KGK A;  3NZD A;  2DHF A;  4ELH A;  3F8Z A;  4PST A;  4RGC A;  4KJK A;  4DFR A;  4XT4 A;  3KFY A;  1KLK A;  2W9S A;  3FL9 A;  1S3W A;  4XE6 X;  4XT5 A;  3SGY A;  2P4G A;  3EIG A;  3FY9 X;  2B3Z A;  2BLB A;  1RC4 A;  3QLW A;  4QJZ D;  1DDR A;  1DYJ A;  3FRF X;  1RA3 A;  1IA3 A;  1DR7 A;  1RA9 A;  1DDS A;  1DR3 A;  4X5F A;  3QGT A;  4M6J A;  3FYW X;  4H97 A;  3DFR A;  3SRW X;  2W9H A;  3EX8 A;  3IRM A;  3IA4 A;  4PDJ A;  1M7A A;  3JWF A;  1U71 A;  1DR6 A;  3K47 A;  2XW7 A;  2BLC A;  3NZC X;  3Q1H A;  3ROA A;  3NXV A;  3SRQ X;  2FZI A;  4ELF A;  3FRE X;  4XT7 A;  4P66 A;  3RO9 A;  3QLX A;  4TU5 X;  1DHF A;  1DYH A;  5HSU A;  4OSG A;  3DAU A;  4QJC A;  3F0S X;  3DGA A;  4KYA A;  4KAK A;  1RF7 A;  4HA9 A;  3JTW A;  5CCC A;  3EEM A;  3ZPC A;  2ZZA A;  5JG0 X;  1U72 A;  5HT5 A;  2FZJ A;  1AOE A;  1KMV A;  3SA1 A;  1S3U A;  1DG5 A;  3NXR A;  3CD2 A;  2AZN A;  5DFR A;  4EIG A;  3I3R A;  3D80 A;  3DL6 A;  4XT8 A;  3QFX A;  1DRF A;  2C2T A;  2D5N A;  1HFP A;  3QYL A;  1RX9 A;  3SA2 A;  2QK8 A;  2GD9 A;  3FQO A;  1JOL A;  1M79 A;  5U26 A;  4PSY A;  1RH3 A;  3FL8 A;  3INV A;  1AO8 A;  4HA7 A;  1D1G A;  1RX4 A;  3KGY A;  1CZ3 A;  1YHO A;  3LG4 A;  3S9U A;  1RB3 A;  1LUD A;  1DRA A;  3F0V X;  1TDR A;  2W3M A;  4KM0 A;  3IA5 A;  3JWM A;  5FDA A;  4M6L A;  4LAE X;  1RB2 A;  5HF2 X;  4ECK A;  3CSE A;  3TQA A;  3NXO A;  1DIU A;  4GH8 A;  4M7V A;  3FRA X;  4FHB A;  2ANQ A;  3K2H A;  3TD8 A;  3NXX A;  2D0K A;  2JYB A;  4H95 A;  1RX6 A;  3JSU A;  4IXG X;  5HQZ A;  3GI2 A;  1J3K A;  5CC9 A;  5HT4 A;  3CL9 A;  5ECX A;  3OCH A;  3IRN A;  3F0U X;  3NXT A;  3F0X X;  1J3J A;  1RX8 A;  2BLA A;  2HQP A;  2W9G A;  4G3M A;  3DL5 A;  4Q0D A;  1S3V A;  3FS6 A;  1HFQ A;  4M6K A;  1IA4 A;  1LY3 A;  3NTZ A;  6DFR A;  3M09 A;  3GHV A;  5E8Q A;  4FGH A;  1DG8 A;  4EJ1 A;  4ELG A;  1BOZ A;  3HBB A;  4KBN A;  5HI6 A;  3QLY A;  1DG7 A;  1S3Y A;  3NZ9 X;  4KNE A;  4QLE A;  1RX2 A;  3I8A X;  3SR5 X;  5DXV A;  3DAT A;  2HXV A;  5HF0 X;  4EIZ A;  3KY8 A;  3FQZ A;  2W3W A;  1RA8 A;  4QHV A;  3F91 A;  4XT6 A;  1MVT A;  1DR1 A;  3QL0 A;  2G6V A;  1QZF A;  2FZH A;  1RG7 A;  2O7P A;  4KY4 A;  3QLZ A;  1MVS A;  3JW3 A;  1JOM A;  4NX6 A;  3NU0 A;  3R33 A;  3NZA X;  2OIP A;  3N0H A;  4DPH A;  4P68 A;  4X5I A;  3QG2 A;  2CIG A;  2W3V A;  3FQC A;  2C2S A;  5HVB A;  5HUI A;  4I1N A;  3FQF A;  4KY8 A;  1RX1 A;  3OAF A;  1CD2 A;  3TQ9 A;  3SRS X;  1LY4 A;  3QLS A;  3SRU X;  4DP3 A;  1DYI A;  4DPD A;  3ZPG A;  4Q6A A;  3FRD X;  5HPB A;  1OHK A;  1IA2 A;  3GHC A;  4KFJ A;  4IXF X;  3F0B X;  3F0Q X;  3JWC A;  1DR5 A;  4NX7 A;  4I13 A;  1J3I A;  1VJ3 A;  8DFR A;  1RD7 A;  1DHI A;  2ITH A;  4QLG A;  2ANO A;  3EEL A;  4LAH X;  4G95 A;  1DAJ A;  5ECC A;  2W3B A;  3TQB A;  3SAI A;  3EEJ A;  3DRC A;  3QL3 A;  4Q67 A;  1RA1 A;  3SRR X;  3NXY A;  1VDR A;  5HVE A;  3GYF A;  3IRO A;  4M2X A;  4Q0E A;  3UM8 A;  1RE7 A;  1DHJ A;  3UM5 A;  4KD7 A;  1RX5 A;  4P3Q A;  4H96 A;  3HJ3 A;  4LAG X;  3VCO A;  2L28 A;  1DR4 A;  3NRR A;  4CD2 A;  3S7A A;  3E0B A;  3F8Y A;  5U27 A;  3JWK A;  3DG8 A;  4H98 A;  3CLB A;  2DRC A;  2LF1 A;  4PSS A;  1DYR A;  1PD8 A;  3RG9 A;  4PTH A;  1KMS A;  4PTJ A;  4QLF A;  3FYV X;  4P3R A;  3JW5 A;  4QI9 A;  7DFR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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