3NZBX

Structural analysis of pneumocystis carinii and human dhfr complexes with nadph and a series of potent 5-(omega-carboxyl(alkyloxy)pyrido[2,-d]pyrimidine derivatives
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
206
structure length
206
Chain Sequence
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-([omega]-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Pneumocystis carinii
molecule keywords Dihydrofolate reductase
total genus 57
structure length 206
sequence length 206
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2010-07-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3nzbX00
2C2SA 4G3MA 3S3VA 3RG9A 3OAFA 3K74A 1DR3A 5HF0X 1DLRA 3QLYA 1IA2A 2BL9A 1S3YA 1BOZA 4OR7A 3IX9A 4KD7A 4FGHA 3NZBX 3IRMA 1DR6A 4Q0EA 3DL5A 3S7AA 3EEKA 3EX8A 2FZIA 3FL9A 1DG8A 2CD2A 4HA7A 2B3ZA 1DYRA 2LF1A 2OIPA 1DHJA 3JSUA 1DG5A 4QLFA 2W3AA 1DR1A 1DAJA 2DHFA 5CC9A 5HVEA 3FY8X 3FREX 3JWMA 3NZCX 3TQBA 4KJKA 2JYBA 1RB3A 3QGTA 2HXVA 3FQOA 3NZDA 3SGYA 1DYHA 4I13A 5CCCA 4H97A 1S3WA 3JW5A 1HFQA 1RE7A 1RG7A 3QFXA 2BLCA 1M7AA 4H98A 3DL6A 3L3RA 3FL8A 2W9SA 1J3KA 3LG4A 3JTWA 4EIZA 1HFRA 3SA2A 3I8AX 1RX3A 4HA9A 5HVBA 1DLSA 2D0KA 1RB2A 3F0XX 1CD2A 1ZDRA 4LAHX 4KNEA 4X5IA 1BZFA 3JWFA 3RO9A 2W9TA 3NRRA 4ECKA 5JA3A 1IA1A 2CIGA 1DRAA 3KGYA 1TDRA 1PD9A 3DGAA 4Q0DA 3SRWX 2FZJA 4P66A 4X5FA 3QLWA 1U72A 4FHBA 1M78A 4KEBA 4KY8A 1PDBA 4PTHA 4LAGX 3K47A 1VDRA 1LY3A 1U70A 2H2QA 4QJZD 2DRCA 4IXGX 3QLSA 3SRQX 5EAJA 4DFRA 3SQYX 1RX8A 3GHVA 4IXED 2L28A 4HOEA 3VCOA 4KY4A 1DRFA 4KJJA 3FRBX 5HPBA 4KJLA 4QI9A 4XE6X 1RX5A 3JWKA 4QLEA 3KY8A 1OHKA 5ECXA 1DDSA 4KAKA 5U27A 3NXXA 4Q6AA 1DYIA 2XW7A 3QYLA 1D1GA 4PDJA 4PSTA 1E26A 3NU0A 1RH3A 3QL0A 5ECCA 3IRNA 4NX6A 3F0UX 3F8ZA 3QLRA 2AZNA 3FQZA 4KM2A 3GHCA 3FRAX 3E0BA 3SRUX 1DDRA 3UM5A 1J3JA 1DF7A 1LUDA 3CL9A 1DR5A 3K45A 3F91A 1RD7A 1OHJA 3GI2A 3TQ8A 3FQFA 4DP3A 2W3BA 4LAEX 4EILA 5JG0X 3SAIA 3F0BX 1RA1A 2W9HA 1YHOA 1DR2A 3N0HA 1S3VA 2ZZAA 4XT4A 5HF2X 3NZ9X 3SRSX 1RX6A 1J3IA 3OCHA 3SRRX 3QG2A 5U26A 3FYVX 2ANQA 2O7PA 4P3QA 2OBCA 2BLAA 1DG7A 1RX9A 1AO8A 5DXVA 3EELA 1AOEA 3FYWX 1RA9A 3D80A 4QJCA 4CD2A 3KFYA 2GD9A 3CSEA 4DPHA 3HBBA 3F0VX 1JUVA 4RGCA 3SR5X 4P68A 3KJSA 1RC4A 3INVA 3GYFA 4HOGA 1M79A 3JW3A 1PD8A 3DFRA 2HQPA 3CLBA 2W3MA 3I3RA 3Q1HA 1AI9A 4QHVA 4H95A 3FQCA 1MVTA 3F0QX 3D84X 4ELGA 5HSUA 1RX4A 4XT6A 4XT7A 4M6LA 3DRCA 7DFRA 2FZHA 3TQAA 5HI6A 1JOLA 4M6JA 1RA3A 5HT5A 4ELHA 2INQA 4QLGA 3NZ6X 4KL9A 5HUIA 3UM8A 3EEMA 3JVXA 3ROAA 4G8ZX 5E8QA 4KLXA 4X5GA 1SEJA 2ANOA 1RA8A 1S3UA 2KGKA 1DHFA 2BLBA 5HQZA 3EIGA 4GH8A 4XT5A 1DIUA 2P4GA 3DG8A 1HFPA 2ITHA 3NXVA 4EIGA 3IA4A 4FGGA 3EEJA 3QYOA 4ELEA 4Q67A 1DHIA 1RX2A 1KMVA 1JOMA 1RX7A 2W9GA 4M6KA 3NXYA 4KM0A 4X5HA 3NXRA 1LY4A 4IXFX 5HT4A 3FS6A 3ZPGA 2W3WA 3TD8A 4NX7A 3HJ3A 5HQYA 3S9UA 3NTZA 4TU5X 1DRBA 4DPDA 3DATA 3CD2A 3DAUA 3R33A 4ELBA 3FQ0A 3NXOA 3SH2A 3F8YA 1QZFA 1KMSA 2C2TA 3TQ9A 3GHWA 3M08A 3QL3A 4P3RA 4M2XA 3NZAX 1KLKA 1MVSA 1RA2A 4HOFA 1DYJA 3UM6A 3QLXA 4M7VA 4PSYA 4XRBA 4LEKX 3ZPCA 2G6VA 1U71A 1DR4A 1RF7A 4PSSA 1IA4A 3FRDX 4ELFA 1CZ3A 4PTJA 3M09A 1DR7A 3QLZA 5DFRA 1RX1A 4OSGA 3SA1A 3JWCA 1DRHA 3F0SX 6DFRA 2QK8A 2HM9A 3IA5A 8DFRA 4XT8A 4KBNA 4I1NA 1VJ3A 2W3VA 4X5JA 3IROA 4XECX 3FQVA 4M7UA 3KJRA 1DISA 4H96A 4EJ1A 3FY9X 4G95A 3NXTA 5HSRA 3K2HA 5FDAA 4KFJA 1IA3A 4KYAA 1DREA 3FRFX 2D5NA 4DDRA
chains in the Genus database with same CATH superfamily
2C2SA 4G3MA 3S3VA 3RG9A 3OAFA 3K74A 1DR3A 5HF0X 1DLRA 3QLYA 1IA2A 2BL9A 1S3YA 1BOZA 4OR7A 3IX9A 4KD7A 4FGHA 3NZBX 3IRMA 1DR6A 4Q0EA 3DL5A 3S7AA 3EEKA 3EX8A 2FZIA 3FL9A 1DG8A 2CD2A 4HA7A 2B3ZA 1DYRA 2LF1A 2OIPA 1DHJA 3JSUA 1DG5A 4QLFA 2W3AA 1DR1A 1DAJA 2DHFA 5CC9A 5HVEA 3FY8X 3FREX 3JWMA 3NZCX 3TQBA 4KJKA 2JYBA 1RB3A 3QGTA 2HXVA 3FQOA 3NZDA 3SGYA 1DYHA 4I13A 5CCCA 4H97A 1S3WA 3JW5A 1HFQA 1RE7A 1RG7A 3QFXA 2BLCA 1M7AA 4H98A 3DL6A 3L3RA 3FL8A 2W9SA 1J3KA 3LG4A 3JTWA 4EIZA 1HFRA 3SA2A 3I8AX 1RX3A 4HA9A 5HVBA 1DLSA 2D0KA 1RB2A 3F0XX 1CD2A 1ZDRA 4LAHX 4KNEA 4X5IA 1BZFA 3JWFA 3RO9A 2W9TA 3NRRA 4ECKA 5JA3A 1IA1A 2CIGA 1DRAA 3KGYA 1TDRA 1PD9A 3DGAA 4Q0DA 3SRWX 2FZJA 4P66A 4X5FA 3QLWA 1U72A 4FHBA 1M78A 4KEBA 4KY8A 1PDBA 4PTHA 4LAGX 3K47A 1VDRA 1LY3A 1U70A 2H2QA 4QJZD 2DRCA 4IXGX 3QLSA 3SRQX 5EAJA 4DFRA 3SQYX 1RX8A 3GHVA 4IXED 2L28A 4HOEA 3VCOA 4KY4A 1DRFA 4KJJA 3FRBX 5HPBA 4KJLA 4QI9A 4XE6X 1RX5A 3JWKA 4QLEA 3KY8A 1OHKA 5ECXA 1DDSA 4KAKA 5U27A 3NXXA 4Q6AA 1DYIA 2XW7A 3QYLA 1D1GA 4PDJA 4PSTA 1E26A 3NU0A 1RH3A 3QL0A 5ECCA 3IRNA 4NX6A 3F0UX 3F8ZA 3QLRA 2AZNA 3FQZA 4KM2A 3GHCA 3FRAX 3E0BA 3SRUX 1DDRA 3UM5A 1J3JA 1DF7A 1LUDA 3CL9A 1DR5A 3K45A 3F91A 1RD7A 1OHJA 3GI2A 3TQ8A 3FQFA 4DP3A 2W3BA 4LAEX 4EILA 5JG0X 3SAIA 3F0BX 1RA1A 2W9HA 1YHOA 1DR2A 3N0HA 1S3VA 2ZZAA 4XT4A 5HF2X 3NZ9X 3SRSX 1RX6A 1J3IA 3OCHA 3SRRX 3QG2A 5U26A 3FYVX 2ANQA 2O7PA 4P3QA 2OBCA 2BLAA 1DG7A 1RX9A 1AO8A 5DXVA 3EELA 1AOEA 3FYWX 1RA9A 3D80A 4QJCA 4CD2A 3KFYA 2GD9A 3CSEA 4DPHA 3HBBA 3F0VX 1JUVA 4RGCA 3SR5X 4P68A 3KJSA 1RC4A 3INVA 3GYFA 4HOGA 1M79A 3JW3A 1PD8A 3DFRA 2HQPA 3CLBA 2W3MA 3I3RA 3Q1HA 1AI9A 4QHVA 4H95A 3FQCA 1MVTA 3F0QX 3D84X 4ELGA 5HSUA 1RX4A 4XT6A 4XT7A 4M6LA 3DRCA 7DFRA 2FZHA 3TQAA 5HI6A 1JOLA 4M6JA 1RA3A 5HT5A 4ELHA 2INQA 4QLGA 3NZ6X 4KL9A 5HUIA 3UM8A 3EEMA 3JVXA 3ROAA 4G8ZX 5E8QA 4KLXA 4X5GA 1SEJA 2ANOA 1RA8A 1S3UA 2KGKA 1DHFA 2BLBA 5HQZA 3EIGA 4GH8A 4XT5A 1DIUA 2P4GA 3DG8A 1HFPA 2ITHA 3NXVA 4EIGA 3IA4A 4FGGA 3EEJA 3QYOA 4ELEA 4Q67A 1DHIA 1RX2A 1KMVA 1JOMA 1RX7A 2W9GA 4M6KA 3NXYA 4KM0A 4X5HA 3NXRA 1LY4A 4IXFX 5HT4A 3FS6A 3ZPGA 2W3WA 3TD8A 4NX7A 3HJ3A 5HQYA 3S9UA 3NTZA 4TU5X 1DRBA 4DPDA 3DATA 3CD2A 3DAUA 3R33A 4ELBA 3FQ0A 3NXOA 3SH2A 3F8YA 1QZFA 1KMSA 2C2TA 3TQ9A 3GHWA 3M08A 3QL3A 4P3RA 4M2XA 3NZAX 1KLKA 1MVSA 1RA2A 4HOFA 1DYJA 3UM6A 3QLXA 4M7VA 4PSYA 4XRBA 4LEKX 3ZPCA 2G6VA 1U71A 1DR4A 1RF7A 4PSSA 1IA4A 3FRDX 4ELFA 1CZ3A 4PTJA 3M09A 1DR7A 3QLZA 5DFRA 1RX1A 4OSGA 3SA1A 3JWCA 1DRHA 3F0SX 6DFRA 2QK8A 2HM9A 3IA5A 8DFRA 4XT8A 4KBNA 4I1NA 1VJ3A 2W3VA 4X5JA 3IROA 4XECX 3FQVA 4M7UA 3KJRA 1DISA 4H96A 4EJ1A 3FY9X 4G95A 3NXTA 5HSRA 3K2HA 5FDAA 4KFJA 1IA3A 4KYAA 1DREA 3FRFX 2D5NA 4DDRA
chains in the Genus database with same CATH topology
2C2SA 4G3MA 3S3VA 3RG9A 3OAFA 3K74A 1DR3A 5HF0X 1DLRA 3QLYA 1IA2A 2BL9A 1S3YA 1BOZA 4OR7A 3IX9A 4KD7A 4FGHA 3NZBX 3IRMA 1DR6A 4Q0EA 3DL5A 3S7AA 3EEKA 3EX8A 2FZIA 3FL9A 1DG8A 2CD2A 4HA7A 2B3ZA 1DYRA 2LF1A 2OIPA 1DHJA 3JSUA 1DG5A 4QLFA 2W3AA 1DR1A 1DAJA 2DHFA 5CC9A 5HVEA 3FY8X 3FREX 3JWMA 3NZCX 3TQBA 4KJKA 2JYBA 1RB3A 3QGTA 2HXVA 3FQOA 3NZDA 3SGYA 1DYHA 4I13A 5CCCA 4H97A 1S3WA 3JW5A 1HFQA 1RE7A 1RG7A 3QFXA 2BLCA 1M7AA 4H98A 3DL6A 3L3RA 3FL8A 2W9SA 1J3KA 3LG4A 3JTWA 4EIZA 1HFRA 3SA2A 3I8AX 1RX3A 4HA9A 5HVBA 1DLSA 2D0KA 1RB2A 3F0XX 1CD2A 1ZDRA 4LAHX 4KNEA 4X5IA 1BZFA 3JWFA 3RO9A 2W9TA 3NRRA 4ECKA 5JA3A 1IA1A 2CIGA 1DRAA 3KGYA 1TDRA 1PD9A 3DGAA 4Q0DA 3SRWX 2FZJA 4P66A 4X5FA 3QLWA 1U72A 4FHBA 1M78A 4KEBA 4KY8A 1PDBA 4PTHA 4LAGX 3K47A 1VDRA 1LY3A 1U70A 2H2QA 4QJZD 2DRCA 4IXGX 3QLSA 3SRQX 5EAJA 4DFRA 3SQYX 1RX8A 3GHVA 4IXED 2L28A 4HOEA 3VCOA 4KY4A 1DRFA 4KJJA 3FRBX 5HPBA 4KJLA 4QI9A 4XE6X 1RX5A 3JWKA 4QLEA 3KY8A 1OHKA 5ECXA 1DDSA 4KAKA 5U27A 3NXXA 4Q6AA 1DYIA 2XW7A 3QYLA 1D1GA 4PDJA 4PSTA 1E26A 3NU0A 1RH3A 3QL0A 5ECCA 3IRNA 4NX6A 3F0UX 3F8ZA 3QLRA 2AZNA 3FQZA 4KM2A 3GHCA 3FRAX 3E0BA 3SRUX 1DDRA 3UM5A 1J3JA 1DF7A 1LUDA 3CL9A 1DR5A 3K45A 3F91A 1RD7A 1OHJA 3GI2A 3TQ8A 3FQFA 4DP3A 2W3BA 4LAEX 4EILA 5JG0X 3SAIA 3F0BX 1RA1A 2W9HA 1YHOA 1DR2A 3N0HA 1S3VA 2ZZAA 4XT4A 5HF2X 3NZ9X 3SRSX 1RX6A 1J3IA 3OCHA 3SRRX 3QG2A 5U26A 3FYVX 2ANQA 2O7PA 4P3QA 2OBCA 2BLAA 1DG7A 1RX9A 1AO8A 5DXVA 3EELA 1AOEA 3FYWX 1RA9A 3D80A 4QJCA 4CD2A 3KFYA 2GD9A 3CSEA 4DPHA 3HBBA 3F0VX 1JUVA 4RGCA 3SR5X 4P68A 3KJSA 1RC4A 3INVA 3GYFA 4HOGA 1M79A 3JW3A 1PD8A 3DFRA 2HQPA 3CLBA 2W3MA 3I3RA 3Q1HA 1AI9A 4QHVA 4H95A 3FQCA 1MVTA 3F0QX 3D84X 4ELGA 5HSUA 1RX4A 4XT6A 4XT7A 4M6LA 3DRCA 7DFRA 2FZHA 3TQAA 5HI6A 1JOLA 4M6JA 1RA3A 5HT5A 4ELHA 2INQA 4QLGA 3NZ6X 4KL9A 5HUIA 3UM8A 3EEMA 3JVXA 3ROAA 4G8ZX 5E8QA 4KLXA 4X5GA 1SEJA 2ANOA 1RA8A 1S3UA 2KGKA 1DHFA 2BLBA 5HQZA 3EIGA 4GH8A 4XT5A 1DIUA 2P4GA 3DG8A 1HFPA 2ITHA 3NXVA 4EIGA 3IA4A 4FGGA 3EEJA 3QYOA 4ELEA 4Q67A 1DHIA 1RX2A 1KMVA 1JOMA 1RX7A 2W9GA 4M6KA 3NXYA 4KM0A 4X5HA 3NXRA 1LY4A 4IXFX 5HT4A 3FS6A 3ZPGA 2W3WA 3TD8A 4NX7A 3HJ3A 5HQYA 3S9UA 3NTZA 4TU5X 1DRBA 4DPDA 3DATA 3CD2A 3DAUA 3R33A 4ELBA 3FQ0A 3NXOA 3SH2A 3F8YA 1QZFA 1KMSA 2C2TA 3TQ9A 3GHWA 3M08A 3QL3A 4P3RA 4M2XA 3NZAX 1KLKA 1MVSA 1RA2A 4HOFA 1DYJA 3UM6A 3QLXA 4M7VA 4PSYA 4XRBA 4LEKX 3ZPCA 2G6VA 1U71A 1DR4A 1RF7A 4PSSA 1IA4A 3FRDX 4ELFA 1CZ3A 4PTJA 3M09A 1DR7A 3QLZA 5DFRA 1RX1A 4OSGA 3SA1A 3JWCA 1DRHA 3F0SX 6DFRA 2QK8A 2HM9A 3IA5A 8DFRA 4XT8A 4KBNA 4I1NA 1VJ3A 2W3VA 4X5JA 3IROA 4XECX 3FQVA 4M7UA 3KJRA 1DISA 4H96A 4EJ1A 3FY9X 4G95A 3NXTA 5HSRA 3K2HA 5FDAA 4KFJA 1IA3A 4KYAA 1DREA 3FRFX 2D5NA 4DDRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2C2S A;  4G3M A;  3S3V A;  3RG9 A;  3OAF A;  3K74 A;  1DR3 A;  5HF0 X;  1DLR A;  3QLY A;  1IA2 A;  2BL9 A;  1S3Y A;  1BOZ A;  4OR7 A;  3IX9 A;  4KD7 A;  4FGH A;  3NZB X;  3IRM A;  1DR6 A;  4Q0E A;  3DL5 A;  3S7A A;  3EEK A;  3EX8 A;  2FZI A;  3FL9 A;  1DG8 A;  2CD2 A;  4HA7 A;  2B3Z A;  1DYR A;  2LF1 A;  2OIP A;  1DHJ A;  3JSU A;  1DG5 A;  4QLF A;  2W3A A;  1DR1 A;  1DAJ A;  2DHF A;  5CC9 A;  5HVE A;  3FY8 X;  3FRE X;  3JWM A;  3NZC X;  3TQB A;  4KJK A;  2JYB A;  1RB3 A;  3QGT A;  2HXV A;  3FQO A;  3NZD A;  3SGY A;  1DYH A;  4I13 A;  5CCC A;  4H97 A;  1S3W A;  3JW5 A;  1HFQ A;  1RE7 A;  1RG7 A;  3QFX A;  2BLC A;  1M7A A;  4H98 A;  3DL6 A;  3L3R A;  3FL8 A;  2W9S A;  1J3K A;  3LG4 A;  3JTW A;  4EIZ A;  1HFR A;  3SA2 A;  3I8A X;  1RX3 A;  4HA9 A;  5HVB A;  1DLS A;  2D0K A;  1RB2 A;  3F0X X;  1CD2 A;  1ZDR A;  4LAH X;  4KNE A;  4X5I A;  1BZF A;  3JWF A;  3RO9 A;  2W9T A;  3NRR A;  4ECK A;  5JA3 A;  1IA1 A;  2CIG A;  1DRA A;  3KGY A;  1TDR A;  1PD9 A;  3DGA A;  4Q0D A;  3SRW X;  2FZJ A;  4P66 A;  4X5F A;  3QLW A;  1U72 A;  4FHB A;  1M78 A;  4KEB A;  4KY8 A;  1PDB A;  4PTH A;  4LAG X;  3K47 A;  1VDR A;  1LY3 A;  1U70 A;  2H2Q A;  4QJZ D;  2DRC A;  4IXG X;  3QLS A;  3SRQ X;  5EAJ A;  4DFR A;  3SQY X;  1RX8 A;  3GHV A;  4IXE D;  2L28 A;  4HOE A;  3VCO A;  4KY4 A;  1DRF A;  4KJJ A;  3FRB X;  5HPB A;  4KJL A;  4QI9 A;  4XE6 X;  1RX5 A;  3JWK A;  4QLE A;  3KY8 A;  1OHK A;  5ECX A;  1DDS A;  4KAK A;  5U27 A;  3NXX A;  4Q6A A;  1DYI A;  2XW7 A;  3QYL A;  1D1G A;  4PDJ A;  4PST A;  1E26 A;  3NU0 A;  1RH3 A;  3QL0 A;  5ECC A;  3IRN A;  4NX6 A;  3F0U X;  3F8Z A;  3QLR A;  2AZN A;  3FQZ A;  4KM2 A;  3GHC A;  3FRA X;  3E0B A;  3SRU X;  1DDR A;  3UM5 A;  1J3J A;  1DF7 A;  1LUD A;  3CL9 A;  1DR5 A;  3K45 A;  3F91 A;  1RD7 A;  1OHJ A;  3GI2 A;  3TQ8 A;  3FQF A;  4DP3 A;  2W3B A;  4LAE X;  4EIL A;  5JG0 X;  3SAI A;  3F0B X;  1RA1 A;  2W9H A;  1YHO A;  1DR2 A;  3N0H A;  1S3V A;  2ZZA A;  4XT4 A;  5HF2 X;  3NZ9 X;  3SRS X;  1RX6 A;  1J3I A;  3OCH A;  3SRR X;  3QG2 A;  5U26 A;  3FYV X;  2ANQ A;  2O7P A;  4P3Q A;  2OBC A;  2BLA A;  1DG7 A;  1RX9 A;  1AO8 A;  5DXV A;  3EEL A;  1AOE A;  3FYW X;  1RA9 A;  3D80 A;  4QJC A;  4CD2 A;  3KFY A;  2GD9 A;  3CSE A;  4DPH A;  3HBB A;  3F0V X;  1JUV A;  4RGC A;  3SR5 X;  4P68 A;  3KJS A;  1RC4 A;  3INV A;  3GYF A;  4HOG A;  1M79 A;  3JW3 A;  1PD8 A;  3DFR A;  2HQP A;  3CLB A;  2W3M A;  3I3R A;  3Q1H A;  1AI9 A;  4QHV A;  4H95 A;  3FQC A;  1MVT A;  3F0Q X;  3D84 X;  4ELG A;  5HSU A;  1RX4 A;  4XT6 A;  4XT7 A;  4M6L A;  3DRC A;  7DFR A;  2FZH A;  3TQA A;  5HI6 A;  1JOL A;  4M6J A;  1RA3 A;  5HT5 A;  4ELH A;  2INQ A;  4QLG A;  3NZ6 X;  4KL9 A;  5HUI A;  3UM8 A;  3EEM A;  3JVX A;  3ROA A;  4G8Z X;  5E8Q A;  4KLX A;  4X5G A;  1SEJ A;  2ANO A;  1RA8 A;  1S3U A;  2KGK A;  1DHF A;  2BLB A;  5HQZ A;  3EIG A;  4GH8 A;  4XT5 A;  1DIU A;  2P4G A;  3DG8 A;  1HFP A;  2ITH A;  3NXV A;  4EIG A;  3IA4 A;  4FGG A;  3EEJ A;  3QYO A;  4ELE A;  4Q67 A;  1DHI A;  1RX2 A;  1KMV A;  1JOM A;  1RX7 A;  2W9G A;  4M6K A;  3NXY A;  4KM0 A;  4X5H A;  3NXR A;  1LY4 A;  4IXF X;  5HT4 A;  3FS6 A;  3ZPG A;  2W3W A;  3TD8 A;  4NX7 A;  3HJ3 A;  5HQY A;  3S9U A;  3NTZ A;  4TU5 X;  1DRB A;  4DPD A;  3DAT A;  3CD2 A;  3DAU A;  3R33 A;  4ELB A;  3FQ0 A;  3NXO A;  3SH2 A;  3F8Y A;  1QZF A;  1KMS A;  2C2T A;  3TQ9 A;  3GHW A;  3M08 A;  3QL3 A;  4P3R A;  4M2X A;  3NZA X;  1KLK A;  1MVS A;  1RA2 A;  4HOF A;  1DYJ A;  3UM6 A;  3QLX A;  4M7V A;  4PSY A;  4XRB A;  4LEK X;  3ZPC A;  2G6V A;  1U71 A;  1DR4 A;  1RF7 A;  4PSS A;  1IA4 A;  3FRD X;  4ELF A;  1CZ3 A;  4PTJ A;  3M09 A;  1DR7 A;  3QLZ A;  5DFR A;  1RX1 A;  4OSG A;  3SA1 A;  3JWC A;  1DRH A;  3F0S X;  6DFR A;  2QK8 A;  2HM9 A;  3IA5 A;  8DFR A;  4XT8 A;  4KBN A;  4I1N A;  1VJ3 A;  2W3V A;  4X5J A;  3IRO A;  4XEC X;  3FQV A;  4M7U A;  3KJR A;  1DIS A;  4H96 A;  4EJ1 A;  3FY9 X;  4G95 A;  3NXT A;  5HSR A;  3K2H A;  5FDA A;  4KFJ A;  1IA3 A;  4KYA A;  1DRE A;  3FRF X;  2D5N A;  4DDR A; 
#chains in the Genus database with same CATH topology
 2C2S A;  4G3M A;  3S3V A;  3RG9 A;  3OAF A;  3K74 A;  1DR3 A;  5HF0 X;  1DLR A;  3QLY A;  1IA2 A;  2BL9 A;  1S3Y A;  1BOZ A;  4OR7 A;  3IX9 A;  4KD7 A;  4FGH A;  3NZB X;  3IRM A;  1DR6 A;  4Q0E A;  3DL5 A;  3S7A A;  3EEK A;  3EX8 A;  2FZI A;  3FL9 A;  1DG8 A;  2CD2 A;  4HA7 A;  2B3Z A;  1DYR A;  2LF1 A;  2OIP A;  1DHJ A;  3JSU A;  1DG5 A;  4QLF A;  2W3A A;  1DR1 A;  1DAJ A;  2DHF A;  5CC9 A;  5HVE A;  3FY8 X;  3FRE X;  3JWM A;  3NZC X;  3TQB A;  4KJK A;  2JYB A;  1RB3 A;  3QGT A;  2HXV A;  3FQO A;  3NZD A;  3SGY A;  1DYH A;  4I13 A;  5CCC A;  4H97 A;  1S3W A;  3JW5 A;  1HFQ A;  1RE7 A;  1RG7 A;  3QFX A;  2BLC A;  1M7A A;  4H98 A;  3DL6 A;  3L3R A;  3FL8 A;  2W9S A;  1J3K A;  3LG4 A;  3JTW A;  4EIZ A;  1HFR A;  3SA2 A;  3I8A X;  1RX3 A;  4HA9 A;  5HVB A;  1DLS A;  2D0K A;  1RB2 A;  3F0X X;  1CD2 A;  1ZDR A;  4LAH X;  4KNE A;  4X5I A;  1BZF A;  3JWF A;  3RO9 A;  2W9T A;  3NRR A;  4ECK A;  5JA3 A;  1IA1 A;  2CIG A;  1DRA A;  3KGY A;  1TDR A;  1PD9 A;  3DGA A;  4Q0D A;  3SRW X;  2FZJ A;  4P66 A;  4X5F A;  3QLW A;  1U72 A;  4FHB A;  1M78 A;  4KEB A;  4KY8 A;  1PDB A;  4PTH A;  4LAG X;  3K47 A;  1VDR A;  1LY3 A;  1U70 A;  2H2Q A;  4QJZ D;  2DRC A;  4IXG X;  3QLS A;  3SRQ X;  5EAJ A;  4DFR A;  3SQY X;  1RX8 A;  3GHV A;  4IXE D;  2L28 A;  4HOE A;  3VCO A;  4KY4 A;  1DRF A;  4KJJ A;  3FRB X;  5HPB A;  4KJL A;  4QI9 A;  4XE6 X;  1RX5 A;  3JWK A;  4QLE A;  3KY8 A;  1OHK A;  5ECX A;  1DDS A;  4KAK A;  5U27 A;  3NXX A;  4Q6A A;  1DYI A;  2XW7 A;  3QYL A;  1D1G A;  4PDJ A;  4PST A;  1E26 A;  3NU0 A;  1RH3 A;  3QL0 A;  5ECC A;  3IRN A;  4NX6 A;  3F0U X;  3F8Z A;  3QLR A;  2AZN A;  3FQZ A;  4KM2 A;  3GHC A;  3FRA X;  3E0B A;  3SRU X;  1DDR A;  3UM5 A;  1J3J A;  1DF7 A;  1LUD A;  3CL9 A;  1DR5 A;  3K45 A;  3F91 A;  1RD7 A;  1OHJ A;  3GI2 A;  3TQ8 A;  3FQF A;  4DP3 A;  2W3B A;  4LAE X;  4EIL A;  5JG0 X;  3SAI A;  3F0B X;  1RA1 A;  2W9H A;  1YHO A;  1DR2 A;  3N0H A;  1S3V A;  2ZZA A;  4XT4 A;  5HF2 X;  3NZ9 X;  3SRS X;  1RX6 A;  1J3I A;  3OCH A;  3SRR X;  3QG2 A;  5U26 A;  3FYV X;  2ANQ A;  2O7P A;  4P3Q A;  2OBC A;  2BLA A;  1DG7 A;  1RX9 A;  1AO8 A;  5DXV A;  3EEL A;  1AOE A;  3FYW X;  1RA9 A;  3D80 A;  4QJC A;  4CD2 A;  3KFY A;  2GD9 A;  3CSE A;  4DPH A;  3HBB A;  3F0V X;  1JUV A;  4RGC A;  3SR5 X;  4P68 A;  3KJS A;  1RC4 A;  3INV A;  3GYF A;  4HOG A;  1M79 A;  3JW3 A;  1PD8 A;  3DFR A;  2HQP A;  3CLB A;  2W3M A;  3I3R A;  3Q1H A;  1AI9 A;  4QHV A;  4H95 A;  3FQC A;  1MVT A;  3F0Q X;  3D84 X;  4ELG A;  5HSU A;  1RX4 A;  4XT6 A;  4XT7 A;  4M6L A;  3DRC A;  7DFR A;  2FZH A;  3TQA A;  5HI6 A;  1JOL A;  4M6J A;  1RA3 A;  5HT5 A;  4ELH A;  2INQ A;  4QLG A;  3NZ6 X;  4KL9 A;  5HUI A;  3UM8 A;  3EEM A;  3JVX A;  3ROA A;  4G8Z X;  5E8Q A;  4KLX A;  4X5G A;  1SEJ A;  2ANO A;  1RA8 A;  1S3U A;  2KGK A;  1DHF A;  2BLB A;  5HQZ A;  3EIG A;  4GH8 A;  4XT5 A;  1DIU A;  2P4G A;  3DG8 A;  1HFP A;  2ITH A;  3NXV A;  4EIG A;  3IA4 A;  4FGG A;  3EEJ A;  3QYO A;  4ELE A;  4Q67 A;  1DHI A;  1RX2 A;  1KMV A;  1JOM A;  1RX7 A;  2W9G A;  4M6K A;  3NXY A;  4KM0 A;  4X5H A;  3NXR A;  1LY4 A;  4IXF X;  5HT4 A;  3FS6 A;  3ZPG A;  2W3W A;  3TD8 A;  4NX7 A;  3HJ3 A;  5HQY A;  3S9U A;  3NTZ A;  4TU5 X;  1DRB A;  4DPD A;  3DAT A;  3CD2 A;  3DAU A;  3R33 A;  4ELB A;  3FQ0 A;  3NXO A;  3SH2 A;  3F8Y A;  1QZF A;  1KMS A;  2C2T A;  3TQ9 A;  3GHW A;  3M08 A;  3QL3 A;  4P3R A;  4M2X A;  3NZA X;  1KLK A;  1MVS A;  1RA2 A;  4HOF A;  1DYJ A;  3UM6 A;  3QLX A;  4M7V A;  4PSY A;  4XRB A;  4LEK X;  3ZPC A;  2G6V A;  1U71 A;  1DR4 A;  1RF7 A;  4PSS A;  1IA4 A;  3FRD X;  4ELF A;  1CZ3 A;  4PTJ A;  3M09 A;  1DR7 A;  3QLZ A;  5DFR A;  1RX1 A;  4OSG A;  3SA1 A;  3JWC A;  1DRH A;  3F0S X;  6DFR A;  2QK8 A;  2HM9 A;  3IA5 A;  8DFR A;  4XT8 A;  4KBN A;  4I1N A;  1VJ3 A;  2W3V A;  4X5J A;  3IRO A;  4XEC X;  3FQV A;  4M7U A;  3KJR A;  1DIS A;  4H96 A;  4EJ1 A;  3FY9 X;  4G95 A;  3NXT A;  5HSR A;  3K2H A;  5FDA A;  4KFJ A;  1IA3 A;  4KYA A;  1DRE A;  3FRF X;  2D5N A;  4DDR A; 
#chains in the Genus database with same CATH homology
 2C2S A;  4G3M A;  3S3V A;  3RG9 A;  3OAF A;  3K74 A;  1DR3 A;  5HF0 X;  1DLR A;  3QLY A;  1IA2 A;  2BL9 A;  1S3Y A;  1BOZ A;  4OR7 A;  3IX9 A;  4KD7 A;  4FGH A;  3NZB X;  3IRM A;  1DR6 A;  4Q0E A;  3DL5 A;  3S7A A;  3EEK A;  3EX8 A;  2FZI A;  3FL9 A;  1DG8 A;  2CD2 A;  4HA7 A;  2B3Z A;  1DYR A;  2LF1 A;  2OIP A;  1DHJ A;  3JSU A;  1DG5 A;  4QLF A;  2W3A A;  1DR1 A;  1DAJ A;  2DHF A;  5CC9 A;  5HVE A;  3FY8 X;  3FRE X;  3JWM A;  3NZC X;  3TQB A;  4KJK A;  2JYB A;  1RB3 A;  3QGT A;  2HXV A;  3FQO A;  3NZD A;  3SGY A;  1DYH A;  4I13 A;  5CCC A;  4H97 A;  1S3W A;  3JW5 A;  1HFQ A;  1RE7 A;  1RG7 A;  3QFX A;  2BLC A;  1M7A A;  4H98 A;  3DL6 A;  3L3R A;  3FL8 A;  2W9S A;  1J3K A;  3LG4 A;  3JTW A;  4EIZ A;  1HFR A;  3SA2 A;  3I8A X;  1RX3 A;  4HA9 A;  5HVB A;  1DLS A;  2D0K A;  1RB2 A;  3F0X X;  1CD2 A;  1ZDR A;  4LAH X;  4KNE A;  4X5I A;  1BZF A;  3JWF A;  3RO9 A;  2W9T A;  3NRR A;  4ECK A;  5JA3 A;  1IA1 A;  2CIG A;  1DRA A;  3KGY A;  1TDR A;  1PD9 A;  3DGA A;  4Q0D A;  3SRW X;  2FZJ A;  4P66 A;  4X5F A;  3QLW A;  1U72 A;  4FHB A;  1M78 A;  4KEB A;  4KY8 A;  1PDB A;  4PTH A;  4LAG X;  3K47 A;  1VDR A;  1LY3 A;  1U70 A;  2H2Q A;  4QJZ D;  2DRC A;  4IXG X;  3QLS A;  3SRQ X;  5EAJ A;  4DFR A;  3SQY X;  1RX8 A;  3GHV A;  4IXE D;  2L28 A;  4HOE A;  3VCO A;  4KY4 A;  1DRF A;  4KJJ A;  3FRB X;  5HPB A;  4KJL A;  4QI9 A;  4XE6 X;  1RX5 A;  3JWK A;  4QLE A;  3KY8 A;  1OHK A;  5ECX A;  1DDS A;  4KAK A;  5U27 A;  3NXX A;  4Q6A A;  1DYI A;  2XW7 A;  3QYL A;  1D1G A;  4PDJ A;  4PST A;  1E26 A;  3NU0 A;  1RH3 A;  3QL0 A;  5ECC A;  3IRN A;  4NX6 A;  3F0U X;  3F8Z A;  3QLR A;  2AZN A;  3FQZ A;  4KM2 A;  3GHC A;  3FRA X;  3E0B A;  3SRU X;  1DDR A;  3UM5 A;  1J3J A;  1DF7 A;  1LUD A;  3CL9 A;  1DR5 A;  3K45 A;  3F91 A;  1RD7 A;  1OHJ A;  3GI2 A;  3TQ8 A;  3FQF A;  4DP3 A;  2W3B A;  4LAE X;  4EIL A;  5JG0 X;  3SAI A;  3F0B X;  1RA1 A;  2W9H A;  1YHO A;  1DR2 A;  3N0H A;  1S3V A;  2ZZA A;  4XT4 A;  5HF2 X;  3NZ9 X;  3SRS X;  1RX6 A;  1J3I A;  3OCH A;  3SRR X;  3QG2 A;  5U26 A;  3FYV X;  2ANQ A;  2O7P A;  4P3Q A;  2OBC A;  2BLA A;  1DG7 A;  1RX9 A;  1AO8 A;  5DXV A;  3EEL A;  1AOE A;  3FYW X;  1RA9 A;  3D80 A;  4QJC A;  4CD2 A;  3KFY A;  2GD9 A;  3CSE A;  4DPH A;  3HBB A;  3F0V X;  1JUV A;  4RGC A;  3SR5 X;  4P68 A;  3KJS A;  1RC4 A;  3INV A;  3GYF A;  4HOG A;  1M79 A;  3JW3 A;  1PD8 A;  3DFR A;  2HQP A;  3CLB A;  2W3M A;  3I3R A;  3Q1H A;  1AI9 A;  4QHV A;  4H95 A;  3FQC A;  1MVT A;  3F0Q X;  3D84 X;  4ELG A;  5HSU A;  1RX4 A;  4XT6 A;  4XT7 A;  4M6L A;  3DRC A;  7DFR A;  2FZH A;  3TQA A;  5HI6 A;  1JOL A;  4M6J A;  1RA3 A;  5HT5 A;  4ELH A;  2INQ A;  4QLG A;  3NZ6 X;  4KL9 A;  5HUI A;  3UM8 A;  3EEM A;  3JVX A;  3ROA A;  4G8Z X;  5E8Q A;  4KLX A;  4X5G A;  1SEJ A;  2ANO A;  1RA8 A;  1S3U A;  2KGK A;  1DHF A;  2BLB A;  5HQZ A;  3EIG A;  4GH8 A;  4XT5 A;  1DIU A;  2P4G A;  3DG8 A;  1HFP A;  2ITH A;  3NXV A;  4EIG A;  3IA4 A;  4FGG A;  3EEJ A;  3QYO A;  4ELE A;  4Q67 A;  1DHI A;  1RX2 A;  1KMV A;  1JOM A;  1RX7 A;  2W9G A;  4M6K A;  3NXY A;  4KM0 A;  4X5H A;  3NXR A;  1LY4 A;  4IXF X;  5HT4 A;  3FS6 A;  3ZPG A;  2W3W A;  3TD8 A;  4NX7 A;  3HJ3 A;  5HQY A;  3S9U A;  3NTZ A;  4TU5 X;  1DRB A;  4DPD A;  3DAT A;  3CD2 A;  3DAU A;  3R33 A;  4ELB A;  3FQ0 A;  3NXO A;  3SH2 A;  3F8Y A;  1QZF A;  1KMS A;  2C2T A;  3TQ9 A;  3GHW A;  3M08 A;  3QL3 A;  4P3R A;  4M2X A;  3NZA X;  1KLK A;  1MVS A;  1RA2 A;  4HOF A;  1DYJ A;  3UM6 A;  3QLX A;  4M7V A;  4PSY A;  4XRB A;  4LEK X;  3ZPC A;  2G6V A;  1U71 A;  1DR4 A;  1RF7 A;  4PSS A;  1IA4 A;  3FRD X;  4ELF A;  1CZ3 A;  4PTJ A;  3M09 A;  1DR7 A;  3QLZ A;  5DFR A;  1RX1 A;  4OSG A;  3SA1 A;  3JWC A;  1DRH A;  3F0S X;  6DFR A;  2QK8 A;  2HM9 A;  3IA5 A;  8DFR A;  4XT8 A;  4KBN A;  4I1N A;  1VJ3 A;  2W3V A;  4X5J A;  3IRO A;  4XEC X;  3FQV A;  4M7U A;  3KJR A;  1DIS A;  4H96 A;  4EJ1 A;  3FY9 X;  4G95 A;  3NXT A;  5HSR A;  3K2H A;  5FDA A;  4KFJ A;  1IA3 A;  4KYA A;  1DRE A;  3FRF X;  2D5N A;  4DDR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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