3QFXA

Trypanosoma brucei dihydrofolate reductase pyrimethamine complex
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
219
structure length
219
Chain Sequence
RPPLRPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKTWDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLVSKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFFDIPAAGTKTPEGLELVRESITDERVSTGAGGKKYQFEKLVPRNS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Trypanosomal dihydrofolate reductase reveals natural antifolate resistance
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Trypanosoma brucei rhodesiense
molecule keywords Bifunctional dihydrofolate reductase-thymidylate synthase
total genus 58
structure length 219
sequence length 219
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2011-01-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3qfxA00
1S3WA 2ZZAA 4ELBA 1DRBA 3KY8A 3FL8A 3F0XX 4EIGA 5ECXA 1PD8A 2INQA 3E0BA 2D0KA 3QLXA 1DR1A 5HQZA 1RX6A 4I1NA 4HOEA 1AO8A 4LAEX 1CD2A 3DATA 4PTHA 3SAIA 2W3AA 3DL5A 1MVTA 2C2SA 1DLSA 1IA3A 3JWCA 4G95A 4KM2A 3NZDA 3DRCA 1CZ3A 1D1GA 3NXXA 1QZFA 1DIUA 1RA3A 5HSRA 4P66A 1PD9A 1RX2A 4GH8A 4TU5X 3FYWX 4EIZA 1VJ3A 2HXVA 4X5HA 3DGAA 3DAUA 1DYHA 4Q67A 3K45A 3R33A 2G6VA 3EELA 3FL9A 2HM9A 4DPDA 3QYLA 1DR2A 4KEBA 3EIGA 2W3BA 4ELGA 3KJRA 5DFRA 4M6KA 3JWFA 3K47A 3KGYA 4DP3A 3S7AA 1RX9A 3FREX 4KL9A 3K74A 3NTZA 4PSTA 4HOGA 1E26A 1U72A 3FYVX 4DPHA 1PDBA 3NZ6X 4PDJA 3N0HA 3QYOA 3ROAA 4G8ZX 4EJ1A 4XT7A 4H96A 3NZCX 5JG0X 3FQCA 1TDRA 1JOMA 4NX7A 3M09A 2HQPA 4DFRA 1RB2A 4ECKA 4HA7A 4FGGA 4QLEA 2BLAA 3SRSX 3TD8A 4Q0EA 3NZ9X 1J3KA 1M78A 5HT5A 4QLFA 3D80A 3SA2A 3TQAA 2FZHA 1J3JA 1KLKA 5HVBA 3GHVA 2DHFA 3NXVA 3FY8X 1LY4A 1J3IA 1DREA 2O7PA 3TQBA 4KM0A 4KAKA 2DRCA 2H2QA 5HT4A 3JWKA 3QGTA 5HI6A 1DR5A 3CSEA 4X5GA 1M7AA 1DR3A 5JA3A 1JUVA 3UM8A 1S3VA 1BZFA 2XW7A 1RX7A 3S9UA 3FRDX 3JWMA 1HFRA 1RA1A 1AOEA 1RB3A 1DYJA 5HSUA 3I8AX 4HOFA 3ZPCA 1RX4A 3K2HA 2AZNA 3NZAX 2LF1A 4XE6X 2L28A 4XECX 4XT4A 2CD2A 2BLCA 4NX6A 1KMSA 3TQ9A 3QG2A 1DDRA 4LAHX 4M6JA 3F8YA 3I3RA 4PTJA 1DG5A 3QLZA 4QJCA 3ZPGA 4KYAA 1S3UA 1DAJA 2JYBA 2ANQA 1IA2A 2P4GA 3NXOA 4Q6AA 4XT5A 3NU0A 4LAGX 4QHVA 5HUIA 3SH2A 1RX8A 3SRUX 1U70A 3NXTA 5DXVA 5EAJA 1DHJA 3EX8A 3NRRA 2C2TA 3FQZA 3D84X 2W9GA 1LY3A 3SRQX 1JOLA 3SQYX 3KJSA 3FQVA 3RO9A 1KMVA 1IA1A 5U27A 4ELFA 3IA4A 1RX3A 4FHBA 4KJLA 6DFRA 4KNEA 5FDAA 3FQ0A 1S3YA 3GHCA 3SGYA 1RA9A 1RF7A 3CD2A 1SEJA 2OBCA 4ELEA 3RG9A 4P3QA 3JTWA 1HFQA 4KFJA 3HBBA 3FRFX 3DFRA 3F0SX 4IXFX 1DG7A 3EEJA 3FRBX 3OCHA 4M7VA 4X5IA 1DR4A 1RA2A 3NZBX 4Q0DA 1ZDRA 1BOZA 4PSYA 3Q1HA 1U71A 4CD2A 2BL9A 1DHIA 4OSGA 3IRMA 3CLBA 5HF0X 4XT6A 5ECCA 3QL0A 1RX5A 3VCOA 4EILA 5U26A 3INVA 3GHWA 3M08A 3JVXA 2W9TA 4LEKX 4KJKA 3UM6A 3FQFA 3F91A 1DRAA 2FZIA 1LUDA 4KLXA 1OHJA 4OR7A 3FS6A 1DYRA 5HQYA 4XRBA 1AI9A 3NXYA 3GI2A 3JSUA 3EEKA 2B3ZA 1DHFA 1DF7A 3NXRA 1DRHA 1DYIA 1M79A 1DISA 3FY9X 5CC9A 4I13A 3OAFA 8DFRA 3SRRX 4QI9A 3UM5A 5HPBA 1RD7A 2BLBA 2FZJA 2OIPA 3SA1A 4X5JA 1MVSA 1DDSA 4DDRA 4H98A 4KD7A 3F0VX 1RG7A 4PSSA 3S3VA 4FGHA 3QLRA 2ITHA 4X5FA 5HVEA 2W9SA 5E8QA 4M2XA 1DLRA 3QLSA 2CIGA 4G3MA 3F0QX 1RC4A 3F0BX 3DL6A 4M6LA 2QK8A 2D5NA 4QJZD 1RX1A 2W3MA 4IXGX 2W3WA 4HA9A 5HF2X 3FRAX 3HJ3A 4QLGA 1DR6A 3IX9A 3SRWX 4KJJA 4H95A 3TQ8A 3JW3A 1RH3A 1HFPA 2KGKA 2ANOA 1DRFA 4ELHA 4KY8A 3L3RA 3QFXA 3DG8A 4IXED 1RA8A 1YHOA 3IRNA 1DR7A 4P68A 7DFRA 1IA4A 3JW5A 3GYFA 4KY4A 4XT8A 4P3RA 3LG4A 3QLYA 1RE7A 5CCCA 4RGCA 3FQOA 3CL9A 4H97A 1DG8A 4M7UA 2W3VA 3IA5A 1VDRA 3SR5X 3EEMA 3KFYA 4KBNA 3IROA 2GD9A 3QL3A 3F0UX 3F8ZA 1OHKA 3QLWA 2W9HA
chains in the Genus database with same CATH superfamily
1S3WA 2ZZAA 4ELBA 1DRBA 3KY8A 3FL8A 3F0XX 4EIGA 5ECXA 1PD8A 2INQA 3E0BA 2D0KA 3QLXA 1DR1A 5HQZA 1RX6A 4I1NA 4HOEA 1AO8A 4LAEX 1CD2A 3DATA 4PTHA 3SAIA 2W3AA 3DL5A 1MVTA 2C2SA 1DLSA 1IA3A 3JWCA 4G95A 4KM2A 3NZDA 3DRCA 1CZ3A 1D1GA 3NXXA 1QZFA 1DIUA 1RA3A 5HSRA 4P66A 1PD9A 1RX2A 4GH8A 4TU5X 3FYWX 4EIZA 1VJ3A 2HXVA 4X5HA 3DGAA 3DAUA 1DYHA 4Q67A 3K45A 3R33A 2G6VA 3EELA 3FL9A 2HM9A 4DPDA 3QYLA 1DR2A 4KEBA 3EIGA 2W3BA 4ELGA 3KJRA 5DFRA 4M6KA 3JWFA 3K47A 3KGYA 4DP3A 3S7AA 1RX9A 3FREX 4KL9A 3K74A 3NTZA 4PSTA 4HOGA 1E26A 1U72A 3FYVX 4DPHA 1PDBA 3NZ6X 4PDJA 3N0HA 3QYOA 3ROAA 4G8ZX 4EJ1A 4XT7A 4H96A 3NZCX 5JG0X 3FQCA 1TDRA 1JOMA 4NX7A 3M09A 2HQPA 4DFRA 1RB2A 4ECKA 4HA7A 4FGGA 4QLEA 2BLAA 3SRSX 3TD8A 4Q0EA 3NZ9X 1J3KA 1M78A 5HT5A 4QLFA 3D80A 3SA2A 3TQAA 2FZHA 1J3JA 1KLKA 5HVBA 3GHVA 2DHFA 3NXVA 3FY8X 1LY4A 1J3IA 1DREA 2O7PA 3TQBA 4KM0A 4KAKA 2DRCA 2H2QA 5HT4A 3JWKA 3QGTA 5HI6A 1DR5A 3CSEA 4X5GA 1M7AA 1DR3A 5JA3A 1JUVA 3UM8A 1S3VA 1BZFA 2XW7A 1RX7A 3S9UA 3FRDX 3JWMA 1HFRA 1RA1A 1AOEA 1RB3A 1DYJA 5HSUA 3I8AX 4HOFA 3ZPCA 1RX4A 3K2HA 2AZNA 3NZAX 2LF1A 4XE6X 2L28A 4XECX 4XT4A 2CD2A 2BLCA 4NX6A 1KMSA 3TQ9A 3QG2A 1DDRA 4LAHX 4M6JA 3F8YA 3I3RA 4PTJA 1DG5A 3QLZA 4QJCA 3ZPGA 4KYAA 1S3UA 1DAJA 2JYBA 2ANQA 1IA2A 2P4GA 3NXOA 4Q6AA 4XT5A 3NU0A 4LAGX 4QHVA 5HUIA 3SH2A 1RX8A 3SRUX 1U70A 3NXTA 5DXVA 5EAJA 1DHJA 3EX8A 3NRRA 2C2TA 3FQZA 3D84X 2W9GA 1LY3A 3SRQX 1JOLA 3SQYX 3KJSA 3FQVA 3RO9A 1KMVA 1IA1A 5U27A 4ELFA 3IA4A 1RX3A 4FHBA 4KJLA 6DFRA 4KNEA 5FDAA 3FQ0A 1S3YA 3GHCA 3SGYA 1RA9A 1RF7A 3CD2A 1SEJA 2OBCA 4ELEA 3RG9A 4P3QA 3JTWA 1HFQA 4KFJA 3HBBA 3FRFX 3DFRA 3F0SX 4IXFX 1DG7A 3EEJA 3FRBX 3OCHA 4M7VA 4X5IA 1DR4A 1RA2A 3NZBX 4Q0DA 1ZDRA 1BOZA 4PSYA 3Q1HA 1U71A 4CD2A 2BL9A 1DHIA 4OSGA 3IRMA 3CLBA 5HF0X 4XT6A 5ECCA 3QL0A 1RX5A 3VCOA 4EILA 5U26A 3INVA 3GHWA 3M08A 3JVXA 2W9TA 4LEKX 4KJKA 3UM6A 3FQFA 3F91A 1DRAA 2FZIA 1LUDA 4KLXA 1OHJA 4OR7A 3FS6A 1DYRA 5HQYA 4XRBA 1AI9A 3NXYA 3GI2A 3JSUA 3EEKA 2B3ZA 1DHFA 1DF7A 3NXRA 1DRHA 1DYIA 1M79A 1DISA 3FY9X 5CC9A 4I13A 3OAFA 8DFRA 3SRRX 4QI9A 3UM5A 5HPBA 1RD7A 2BLBA 2FZJA 2OIPA 3SA1A 4X5JA 1MVSA 1DDSA 4DDRA 4H98A 4KD7A 3F0VX 1RG7A 4PSSA 3S3VA 4FGHA 3QLRA 2ITHA 4X5FA 5HVEA 2W9SA 5E8QA 4M2XA 1DLRA 3QLSA 2CIGA 4G3MA 3F0QX 1RC4A 3F0BX 3DL6A 4M6LA 2QK8A 2D5NA 4QJZD 1RX1A 2W3MA 4IXGX 2W3WA 4HA9A 5HF2X 3FRAX 3HJ3A 4QLGA 1DR6A 3IX9A 3SRWX 4KJJA 4H95A 3TQ8A 3JW3A 1RH3A 1HFPA 2KGKA 2ANOA 1DRFA 4ELHA 4KY8A 3L3RA 3QFXA 3DG8A 4IXED 1RA8A 1YHOA 3IRNA 1DR7A 4P68A 7DFRA 1IA4A 3JW5A 3GYFA 4KY4A 4XT8A 4P3RA 3LG4A 3QLYA 1RE7A 5CCCA 4RGCA 3FQOA 3CL9A 4H97A 1DG8A 4M7UA 2W3VA 3IA5A 1VDRA 3SR5X 3EEMA 3KFYA 4KBNA 3IROA 2GD9A 3QL3A 3F0UX 3F8ZA 1OHKA 3QLWA 2W9HA
chains in the Genus database with same CATH topology
1S3WA 2ZZAA 4ELBA 1DRBA 3KY8A 3FL8A 3F0XX 4EIGA 5ECXA 1PD8A 2INQA 3E0BA 2D0KA 3QLXA 1DR1A 5HQZA 1RX6A 4I1NA 4HOEA 1AO8A 4LAEX 1CD2A 3DATA 4PTHA 3SAIA 2W3AA 3DL5A 1MVTA 2C2SA 1DLSA 1IA3A 3JWCA 4G95A 4KM2A 3NZDA 3DRCA 1CZ3A 1D1GA 3NXXA 1QZFA 1DIUA 1RA3A 5HSRA 4P66A 1PD9A 1RX2A 4GH8A 4TU5X 3FYWX 4EIZA 1VJ3A 2HXVA 4X5HA 3DGAA 3DAUA 1DYHA 4Q67A 3K45A 3R33A 2G6VA 3EELA 3FL9A 2HM9A 4DPDA 3QYLA 1DR2A 4KEBA 3EIGA 2W3BA 4ELGA 3KJRA 5DFRA 4M6KA 3JWFA 3K47A 3KGYA 4DP3A 3S7AA 1RX9A 3FREX 4KL9A 3K74A 3NTZA 4PSTA 4HOGA 1E26A 1U72A 3FYVX 4DPHA 1PDBA 3NZ6X 4PDJA 3N0HA 3QYOA 3ROAA 4G8ZX 4EJ1A 4XT7A 4H96A 3NZCX 5JG0X 3FQCA 1TDRA 1JOMA 4NX7A 3M09A 2HQPA 4DFRA 1RB2A 4ECKA 4HA7A 4FGGA 4QLEA 2BLAA 3SRSX 3TD8A 4Q0EA 3NZ9X 1J3KA 1M78A 5HT5A 4QLFA 3D80A 3SA2A 3TQAA 2FZHA 1J3JA 1KLKA 5HVBA 3GHVA 2DHFA 3NXVA 3FY8X 1LY4A 1J3IA 1DREA 2O7PA 3TQBA 4KM0A 4KAKA 2DRCA 2H2QA 5HT4A 3JWKA 3QGTA 5HI6A 1DR5A 3CSEA 4X5GA 1M7AA 1DR3A 5JA3A 1JUVA 3UM8A 1S3VA 1BZFA 2XW7A 1RX7A 3S9UA 3FRDX 3JWMA 1HFRA 1RA1A 1AOEA 1RB3A 1DYJA 5HSUA 3I8AX 4HOFA 3ZPCA 1RX4A 3K2HA 2AZNA 3NZAX 2LF1A 4XE6X 2L28A 4XECX 4XT4A 2CD2A 2BLCA 4NX6A 1KMSA 3TQ9A 3QG2A 1DDRA 4LAHX 4M6JA 3F8YA 3I3RA 4PTJA 1DG5A 3QLZA 4QJCA 3ZPGA 4KYAA 1S3UA 1DAJA 2JYBA 2ANQA 1IA2A 2P4GA 3NXOA 4Q6AA 4XT5A 3NU0A 4LAGX 4QHVA 5HUIA 3SH2A 1RX8A 3SRUX 1U70A 3NXTA 5DXVA 5EAJA 1DHJA 3EX8A 3NRRA 2C2TA 3FQZA 3D84X 2W9GA 1LY3A 3SRQX 1JOLA 3SQYX 3KJSA 3FQVA 3RO9A 1KMVA 1IA1A 5U27A 4ELFA 3IA4A 1RX3A 4FHBA 4KJLA 6DFRA 4KNEA 5FDAA 3FQ0A 1S3YA 3GHCA 3SGYA 1RA9A 1RF7A 3CD2A 1SEJA 2OBCA 4ELEA 3RG9A 4P3QA 3JTWA 1HFQA 4KFJA 3HBBA 3FRFX 3DFRA 3F0SX 4IXFX 1DG7A 3EEJA 3FRBX 3OCHA 4M7VA 4X5IA 1DR4A 1RA2A 3NZBX 4Q0DA 1ZDRA 1BOZA 4PSYA 3Q1HA 1U71A 4CD2A 2BL9A 1DHIA 4OSGA 3IRMA 3CLBA 5HF0X 4XT6A 5ECCA 3QL0A 1RX5A 3VCOA 4EILA 5U26A 3INVA 3GHWA 3M08A 3JVXA 2W9TA 4LEKX 4KJKA 3UM6A 3FQFA 3F91A 1DRAA 2FZIA 1LUDA 4KLXA 1OHJA 4OR7A 3FS6A 1DYRA 5HQYA 4XRBA 1AI9A 3NXYA 3GI2A 3JSUA 3EEKA 2B3ZA 1DHFA 1DF7A 3NXRA 1DRHA 1DYIA 1M79A 1DISA 3FY9X 5CC9A 4I13A 3OAFA 8DFRA 3SRRX 4QI9A 3UM5A 5HPBA 1RD7A 2BLBA 2FZJA 2OIPA 3SA1A 4X5JA 1MVSA 1DDSA 4DDRA 4H98A 4KD7A 3F0VX 1RG7A 4PSSA 3S3VA 4FGHA 3QLRA 2ITHA 4X5FA 5HVEA 2W9SA 5E8QA 4M2XA 1DLRA 3QLSA 2CIGA 4G3MA 3F0QX 1RC4A 3F0BX 3DL6A 4M6LA 2QK8A 2D5NA 4QJZD 1RX1A 2W3MA 4IXGX 2W3WA 4HA9A 5HF2X 3FRAX 3HJ3A 4QLGA 1DR6A 3IX9A 3SRWX 4KJJA 4H95A 3TQ8A 3JW3A 1RH3A 1HFPA 2KGKA 2ANOA 1DRFA 4ELHA 4KY8A 3L3RA 3QFXA 3DG8A 4IXED 1RA8A 1YHOA 3IRNA 1DR7A 4P68A 7DFRA 1IA4A 3JW5A 3GYFA 4KY4A 4XT8A 4P3RA 3LG4A 3QLYA 1RE7A 5CCCA 4RGCA 3FQOA 3CL9A 4H97A 1DG8A 4M7UA 2W3VA 3IA5A 1VDRA 3SR5X 3EEMA 3KFYA 4KBNA 3IROA 2GD9A 3QL3A 3F0UX 3F8ZA 1OHKA 3QLWA 2W9HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S3W A;  2ZZA A;  4ELB A;  1DRB A;  3KY8 A;  3FL8 A;  3F0X X;  4EIG A;  5ECX A;  1PD8 A;  2INQ A;  3E0B A;  2D0K A;  3QLX A;  1DR1 A;  5HQZ A;  1RX6 A;  4I1N A;  4HOE A;  1AO8 A;  4LAE X;  1CD2 A;  3DAT A;  4PTH A;  3SAI A;  2W3A A;  3DL5 A;  1MVT A;  2C2S A;  1DLS A;  1IA3 A;  3JWC A;  4G95 A;  4KM2 A;  3NZD A;  3DRC A;  1CZ3 A;  1D1G A;  3NXX A;  1QZF A;  1DIU A;  1RA3 A;  5HSR A;  4P66 A;  1PD9 A;  1RX2 A;  4GH8 A;  4TU5 X;  3FYW X;  4EIZ A;  1VJ3 A;  2HXV A;  4X5H A;  3DGA A;  3DAU A;  1DYH A;  4Q67 A;  3K45 A;  3R33 A;  2G6V A;  3EEL A;  3FL9 A;  2HM9 A;  4DPD A;  3QYL A;  1DR2 A;  4KEB A;  3EIG A;  2W3B A;  4ELG A;  3KJR A;  5DFR A;  4M6K A;  3JWF A;  3K47 A;  3KGY A;  4DP3 A;  3S7A A;  1RX9 A;  3FRE X;  4KL9 A;  3K74 A;  3NTZ A;  4PST A;  4HOG A;  1E26 A;  1U72 A;  3FYV X;  4DPH A;  1PDB A;  3NZ6 X;  4PDJ A;  3N0H A;  3QYO A;  3ROA A;  4G8Z X;  4EJ1 A;  4XT7 A;  4H96 A;  3NZC X;  5JG0 X;  3FQC A;  1TDR A;  1JOM A;  4NX7 A;  3M09 A;  2HQP A;  4DFR A;  1RB2 A;  4ECK A;  4HA7 A;  4FGG A;  4QLE A;  2BLA A;  3SRS X;  3TD8 A;  4Q0E A;  3NZ9 X;  1J3K A;  1M78 A;  5HT5 A;  4QLF A;  3D80 A;  3SA2 A;  3TQA A;  2FZH A;  1J3J A;  1KLK A;  5HVB A;  3GHV A;  2DHF A;  3NXV A;  3FY8 X;  1LY4 A;  1J3I A;  1DRE A;  2O7P A;  3TQB A;  4KM0 A;  4KAK A;  2DRC A;  2H2Q A;  5HT4 A;  3JWK A;  3QGT A;  5HI6 A;  1DR5 A;  3CSE A;  4X5G A;  1M7A A;  1DR3 A;  5JA3 A;  1JUV A;  3UM8 A;  1S3V A;  1BZF A;  2XW7 A;  1RX7 A;  3S9U A;  3FRD X;  3JWM A;  1HFR A;  1RA1 A;  1AOE A;  1RB3 A;  1DYJ A;  5HSU A;  3I8A X;  4HOF A;  3ZPC A;  1RX4 A;  3K2H A;  2AZN A;  3NZA X;  2LF1 A;  4XE6 X;  2L28 A;  4XEC X;  4XT4 A;  2CD2 A;  2BLC A;  4NX6 A;  1KMS A;  3TQ9 A;  3QG2 A;  1DDR A;  4LAH X;  4M6J A;  3F8Y A;  3I3R A;  4PTJ A;  1DG5 A;  3QLZ A;  4QJC A;  3ZPG A;  4KYA A;  1S3U A;  1DAJ A;  2JYB A;  2ANQ A;  1IA2 A;  2P4G A;  3NXO A;  4Q6A A;  4XT5 A;  3NU0 A;  4LAG X;  4QHV A;  5HUI A;  3SH2 A;  1RX8 A;  3SRU X;  1U70 A;  3NXT A;  5DXV A;  5EAJ A;  1DHJ A;  3EX8 A;  3NRR A;  2C2T A;  3FQZ A;  3D84 X;  2W9G A;  1LY3 A;  3SRQ X;  1JOL A;  3SQY X;  3KJS A;  3FQV A;  3RO9 A;  1KMV A;  1IA1 A;  5U27 A;  4ELF A;  3IA4 A;  1RX3 A;  4FHB A;  4KJL A;  6DFR A;  4KNE A;  5FDA A;  3FQ0 A;  1S3Y A;  3GHC A;  3SGY A;  1RA9 A;  1RF7 A;  3CD2 A;  1SEJ A;  2OBC A;  4ELE A;  3RG9 A;  4P3Q A;  3JTW A;  1HFQ A;  4KFJ A;  3HBB A;  3FRF X;  3DFR A;  3F0S X;  4IXF X;  1DG7 A;  3EEJ A;  3FRB X;  3OCH A;  4M7V A;  4X5I A;  1DR4 A;  1RA2 A;  3NZB X;  4Q0D A;  1ZDR A;  1BOZ A;  4PSY A;  3Q1H A;  1U71 A;  4CD2 A;  2BL9 A;  1DHI A;  4OSG A;  3IRM A;  3CLB A;  5HF0 X;  4XT6 A;  5ECC A;  3QL0 A;  1RX5 A;  3VCO A;  4EIL A;  5U26 A;  3INV A;  3GHW A;  3M08 A;  3JVX A;  2W9T A;  4LEK X;  4KJK A;  3UM6 A;  3FQF A;  3F91 A;  1DRA A;  2FZI A;  1LUD A;  4KLX A;  1OHJ A;  4OR7 A;  3FS6 A;  1DYR A;  5HQY A;  4XRB A;  1AI9 A;  3NXY A;  3GI2 A;  3JSU A;  3EEK A;  2B3Z A;  1DHF A;  1DF7 A;  3NXR A;  1DRH A;  1DYI A;  1M79 A;  1DIS A;  3FY9 X;  5CC9 A;  4I13 A;  3OAF A;  8DFR A;  3SRR X;  4QI9 A;  3UM5 A;  5HPB A;  1RD7 A;  2BLB A;  2FZJ A;  2OIP A;  3SA1 A;  4X5J A;  1MVS A;  1DDS A;  4DDR A;  4H98 A;  4KD7 A;  3F0V X;  1RG7 A;  4PSS A;  3S3V A;  4FGH A;  3QLR A;  2ITH A;  4X5F A;  5HVE A;  2W9S A;  5E8Q A;  4M2X A;  1DLR A;  3QLS A;  2CIG A;  4G3M A;  3F0Q X;  1RC4 A;  3F0B X;  3DL6 A;  4M6L A;  2QK8 A;  2D5N A;  4QJZ D;  1RX1 A;  2W3M A;  4IXG X;  2W3W A;  4HA9 A;  5HF2 X;  3FRA X;  3HJ3 A;  4QLG A;  1DR6 A;  3IX9 A;  3SRW X;  4KJJ A;  4H95 A;  3TQ8 A;  3JW3 A;  1RH3 A;  1HFP A;  2KGK A;  2ANO A;  1DRF A;  4ELH A;  4KY8 A;  3L3R A;  3QFX A;  3DG8 A;  4IXE D;  1RA8 A;  1YHO A;  3IRN A;  1DR7 A;  4P68 A;  7DFR A;  1IA4 A;  3JW5 A;  3GYF A;  4KY4 A;  4XT8 A;  4P3R A;  3LG4 A;  3QLY A;  1RE7 A;  5CCC A;  4RGC A;  3FQO A;  3CL9 A;  4H97 A;  1DG8 A;  4M7U A;  2W3V A;  3IA5 A;  1VDR A;  3SR5 X;  3EEM A;  3KFY A;  4KBN A;  3IRO A;  2GD9 A;  3QL3 A;  3F0U X;  3F8Z A;  1OHK A;  3QLW A;  2W9H A; 
#chains in the Genus database with same CATH topology
 1S3W A;  2ZZA A;  4ELB A;  1DRB A;  3KY8 A;  3FL8 A;  3F0X X;  4EIG A;  5ECX A;  1PD8 A;  2INQ A;  3E0B A;  2D0K A;  3QLX A;  1DR1 A;  5HQZ A;  1RX6 A;  4I1N A;  4HOE A;  1AO8 A;  4LAE X;  1CD2 A;  3DAT A;  4PTH A;  3SAI A;  2W3A A;  3DL5 A;  1MVT A;  2C2S A;  1DLS A;  1IA3 A;  3JWC A;  4G95 A;  4KM2 A;  3NZD A;  3DRC A;  1CZ3 A;  1D1G A;  3NXX A;  1QZF A;  1DIU A;  1RA3 A;  5HSR A;  4P66 A;  1PD9 A;  1RX2 A;  4GH8 A;  4TU5 X;  3FYW X;  4EIZ A;  1VJ3 A;  2HXV A;  4X5H A;  3DGA A;  3DAU A;  1DYH A;  4Q67 A;  3K45 A;  3R33 A;  2G6V A;  3EEL A;  3FL9 A;  2HM9 A;  4DPD A;  3QYL A;  1DR2 A;  4KEB A;  3EIG A;  2W3B A;  4ELG A;  3KJR A;  5DFR A;  4M6K A;  3JWF A;  3K47 A;  3KGY A;  4DP3 A;  3S7A A;  1RX9 A;  3FRE X;  4KL9 A;  3K74 A;  3NTZ A;  4PST A;  4HOG A;  1E26 A;  1U72 A;  3FYV X;  4DPH A;  1PDB A;  3NZ6 X;  4PDJ A;  3N0H A;  3QYO A;  3ROA A;  4G8Z X;  4EJ1 A;  4XT7 A;  4H96 A;  3NZC X;  5JG0 X;  3FQC A;  1TDR A;  1JOM A;  4NX7 A;  3M09 A;  2HQP A;  4DFR A;  1RB2 A;  4ECK A;  4HA7 A;  4FGG A;  4QLE A;  2BLA A;  3SRS X;  3TD8 A;  4Q0E A;  3NZ9 X;  1J3K A;  1M78 A;  5HT5 A;  4QLF A;  3D80 A;  3SA2 A;  3TQA A;  2FZH A;  1J3J A;  1KLK A;  5HVB A;  3GHV A;  2DHF A;  3NXV A;  3FY8 X;  1LY4 A;  1J3I A;  1DRE A;  2O7P A;  3TQB A;  4KM0 A;  4KAK A;  2DRC A;  2H2Q A;  5HT4 A;  3JWK A;  3QGT A;  5HI6 A;  1DR5 A;  3CSE A;  4X5G A;  1M7A A;  1DR3 A;  5JA3 A;  1JUV A;  3UM8 A;  1S3V A;  1BZF A;  2XW7 A;  1RX7 A;  3S9U A;  3FRD X;  3JWM A;  1HFR A;  1RA1 A;  1AOE A;  1RB3 A;  1DYJ A;  5HSU A;  3I8A X;  4HOF A;  3ZPC A;  1RX4 A;  3K2H A;  2AZN A;  3NZA X;  2LF1 A;  4XE6 X;  2L28 A;  4XEC X;  4XT4 A;  2CD2 A;  2BLC A;  4NX6 A;  1KMS A;  3TQ9 A;  3QG2 A;  1DDR A;  4LAH X;  4M6J A;  3F8Y A;  3I3R A;  4PTJ A;  1DG5 A;  3QLZ A;  4QJC A;  3ZPG A;  4KYA A;  1S3U A;  1DAJ A;  2JYB A;  2ANQ A;  1IA2 A;  2P4G A;  3NXO A;  4Q6A A;  4XT5 A;  3NU0 A;  4LAG X;  4QHV A;  5HUI A;  3SH2 A;  1RX8 A;  3SRU X;  1U70 A;  3NXT A;  5DXV A;  5EAJ A;  1DHJ A;  3EX8 A;  3NRR A;  2C2T A;  3FQZ A;  3D84 X;  2W9G A;  1LY3 A;  3SRQ X;  1JOL A;  3SQY X;  3KJS A;  3FQV A;  3RO9 A;  1KMV A;  1IA1 A;  5U27 A;  4ELF A;  3IA4 A;  1RX3 A;  4FHB A;  4KJL A;  6DFR A;  4KNE A;  5FDA A;  3FQ0 A;  1S3Y A;  3GHC A;  3SGY A;  1RA9 A;  1RF7 A;  3CD2 A;  1SEJ A;  2OBC A;  4ELE A;  3RG9 A;  4P3Q A;  3JTW A;  1HFQ A;  4KFJ A;  3HBB A;  3FRF X;  3DFR A;  3F0S X;  4IXF X;  1DG7 A;  3EEJ A;  3FRB X;  3OCH A;  4M7V A;  4X5I A;  1DR4 A;  1RA2 A;  3NZB X;  4Q0D A;  1ZDR A;  1BOZ A;  4PSY A;  3Q1H A;  1U71 A;  4CD2 A;  2BL9 A;  1DHI A;  4OSG A;  3IRM A;  3CLB A;  5HF0 X;  4XT6 A;  5ECC A;  3QL0 A;  1RX5 A;  3VCO A;  4EIL A;  5U26 A;  3INV A;  3GHW A;  3M08 A;  3JVX A;  2W9T A;  4LEK X;  4KJK A;  3UM6 A;  3FQF A;  3F91 A;  1DRA A;  2FZI A;  1LUD A;  4KLX A;  1OHJ A;  4OR7 A;  3FS6 A;  1DYR A;  5HQY A;  4XRB A;  1AI9 A;  3NXY A;  3GI2 A;  3JSU A;  3EEK A;  2B3Z A;  1DHF A;  1DF7 A;  3NXR A;  1DRH A;  1DYI A;  1M79 A;  1DIS A;  3FY9 X;  5CC9 A;  4I13 A;  3OAF A;  8DFR A;  3SRR X;  4QI9 A;  3UM5 A;  5HPB A;  1RD7 A;  2BLB A;  2FZJ A;  2OIP A;  3SA1 A;  4X5J A;  1MVS A;  1DDS A;  4DDR A;  4H98 A;  4KD7 A;  3F0V X;  1RG7 A;  4PSS A;  3S3V A;  4FGH A;  3QLR A;  2ITH A;  4X5F A;  5HVE A;  2W9S A;  5E8Q A;  4M2X A;  1DLR A;  3QLS A;  2CIG A;  4G3M A;  3F0Q X;  1RC4 A;  3F0B X;  3DL6 A;  4M6L A;  2QK8 A;  2D5N A;  4QJZ D;  1RX1 A;  2W3M A;  4IXG X;  2W3W A;  4HA9 A;  5HF2 X;  3FRA X;  3HJ3 A;  4QLG A;  1DR6 A;  3IX9 A;  3SRW X;  4KJJ A;  4H95 A;  3TQ8 A;  3JW3 A;  1RH3 A;  1HFP A;  2KGK A;  2ANO A;  1DRF A;  4ELH A;  4KY8 A;  3L3R A;  3QFX A;  3DG8 A;  4IXE D;  1RA8 A;  1YHO A;  3IRN A;  1DR7 A;  4P68 A;  7DFR A;  1IA4 A;  3JW5 A;  3GYF A;  4KY4 A;  4XT8 A;  4P3R A;  3LG4 A;  3QLY A;  1RE7 A;  5CCC A;  4RGC A;  3FQO A;  3CL9 A;  4H97 A;  1DG8 A;  4M7U A;  2W3V A;  3IA5 A;  1VDR A;  3SR5 X;  3EEM A;  3KFY A;  4KBN A;  3IRO A;  2GD9 A;  3QL3 A;  3F0U X;  3F8Z A;  1OHK A;  3QLW A;  2W9H A; 
#chains in the Genus database with same CATH homology
 1S3W A;  2ZZA A;  4ELB A;  1DRB A;  3KY8 A;  3FL8 A;  3F0X X;  4EIG A;  5ECX A;  1PD8 A;  2INQ A;  3E0B A;  2D0K A;  3QLX A;  1DR1 A;  5HQZ A;  1RX6 A;  4I1N A;  4HOE A;  1AO8 A;  4LAE X;  1CD2 A;  3DAT A;  4PTH A;  3SAI A;  2W3A A;  3DL5 A;  1MVT A;  2C2S A;  1DLS A;  1IA3 A;  3JWC A;  4G95 A;  4KM2 A;  3NZD A;  3DRC A;  1CZ3 A;  1D1G A;  3NXX A;  1QZF A;  1DIU A;  1RA3 A;  5HSR A;  4P66 A;  1PD9 A;  1RX2 A;  4GH8 A;  4TU5 X;  3FYW X;  4EIZ A;  1VJ3 A;  2HXV A;  4X5H A;  3DGA A;  3DAU A;  1DYH A;  4Q67 A;  3K45 A;  3R33 A;  2G6V A;  3EEL A;  3FL9 A;  2HM9 A;  4DPD A;  3QYL A;  1DR2 A;  4KEB A;  3EIG A;  2W3B A;  4ELG A;  3KJR A;  5DFR A;  4M6K A;  3JWF A;  3K47 A;  3KGY A;  4DP3 A;  3S7A A;  1RX9 A;  3FRE X;  4KL9 A;  3K74 A;  3NTZ A;  4PST A;  4HOG A;  1E26 A;  1U72 A;  3FYV X;  4DPH A;  1PDB A;  3NZ6 X;  4PDJ A;  3N0H A;  3QYO A;  3ROA A;  4G8Z X;  4EJ1 A;  4XT7 A;  4H96 A;  3NZC X;  5JG0 X;  3FQC A;  1TDR A;  1JOM A;  4NX7 A;  3M09 A;  2HQP A;  4DFR A;  1RB2 A;  4ECK A;  4HA7 A;  4FGG A;  4QLE A;  2BLA A;  3SRS X;  3TD8 A;  4Q0E A;  3NZ9 X;  1J3K A;  1M78 A;  5HT5 A;  4QLF A;  3D80 A;  3SA2 A;  3TQA A;  2FZH A;  1J3J A;  1KLK A;  5HVB A;  3GHV A;  2DHF A;  3NXV A;  3FY8 X;  1LY4 A;  1J3I A;  1DRE A;  2O7P A;  3TQB A;  4KM0 A;  4KAK A;  2DRC A;  2H2Q A;  5HT4 A;  3JWK A;  3QGT A;  5HI6 A;  1DR5 A;  3CSE A;  4X5G A;  1M7A A;  1DR3 A;  5JA3 A;  1JUV A;  3UM8 A;  1S3V A;  1BZF A;  2XW7 A;  1RX7 A;  3S9U A;  3FRD X;  3JWM A;  1HFR A;  1RA1 A;  1AOE A;  1RB3 A;  1DYJ A;  5HSU A;  3I8A X;  4HOF A;  3ZPC A;  1RX4 A;  3K2H A;  2AZN A;  3NZA X;  2LF1 A;  4XE6 X;  2L28 A;  4XEC X;  4XT4 A;  2CD2 A;  2BLC A;  4NX6 A;  1KMS A;  3TQ9 A;  3QG2 A;  1DDR A;  4LAH X;  4M6J A;  3F8Y A;  3I3R A;  4PTJ A;  1DG5 A;  3QLZ A;  4QJC A;  3ZPG A;  4KYA A;  1S3U A;  1DAJ A;  2JYB A;  2ANQ A;  1IA2 A;  2P4G A;  3NXO A;  4Q6A A;  4XT5 A;  3NU0 A;  4LAG X;  4QHV A;  5HUI A;  3SH2 A;  1RX8 A;  3SRU X;  1U70 A;  3NXT A;  5DXV A;  5EAJ A;  1DHJ A;  3EX8 A;  3NRR A;  2C2T A;  3FQZ A;  3D84 X;  2W9G A;  1LY3 A;  3SRQ X;  1JOL A;  3SQY X;  3KJS A;  3FQV A;  3RO9 A;  1KMV A;  1IA1 A;  5U27 A;  4ELF A;  3IA4 A;  1RX3 A;  4FHB A;  4KJL A;  6DFR A;  4KNE A;  5FDA A;  3FQ0 A;  1S3Y A;  3GHC A;  3SGY A;  1RA9 A;  1RF7 A;  3CD2 A;  1SEJ A;  2OBC A;  4ELE A;  3RG9 A;  4P3Q A;  3JTW A;  1HFQ A;  4KFJ A;  3HBB A;  3FRF X;  3DFR A;  3F0S X;  4IXF X;  1DG7 A;  3EEJ A;  3FRB X;  3OCH A;  4M7V A;  4X5I A;  1DR4 A;  1RA2 A;  3NZB X;  4Q0D A;  1ZDR A;  1BOZ A;  4PSY A;  3Q1H A;  1U71 A;  4CD2 A;  2BL9 A;  1DHI A;  4OSG A;  3IRM A;  3CLB A;  5HF0 X;  4XT6 A;  5ECC A;  3QL0 A;  1RX5 A;  3VCO A;  4EIL A;  5U26 A;  3INV A;  3GHW A;  3M08 A;  3JVX A;  2W9T A;  4LEK X;  4KJK A;  3UM6 A;  3FQF A;  3F91 A;  1DRA A;  2FZI A;  1LUD A;  4KLX A;  1OHJ A;  4OR7 A;  3FS6 A;  1DYR A;  5HQY A;  4XRB A;  1AI9 A;  3NXY A;  3GI2 A;  3JSU A;  3EEK A;  2B3Z A;  1DHF A;  1DF7 A;  3NXR A;  1DRH A;  1DYI A;  1M79 A;  1DIS A;  3FY9 X;  5CC9 A;  4I13 A;  3OAF A;  8DFR A;  3SRR X;  4QI9 A;  3UM5 A;  5HPB A;  1RD7 A;  2BLB A;  2FZJ A;  2OIP A;  3SA1 A;  4X5J A;  1MVS A;  1DDS A;  4DDR A;  4H98 A;  4KD7 A;  3F0V X;  1RG7 A;  4PSS A;  3S3V A;  4FGH A;  3QLR A;  2ITH A;  4X5F A;  5HVE A;  2W9S A;  5E8Q A;  4M2X A;  1DLR A;  3QLS A;  2CIG A;  4G3M A;  3F0Q X;  1RC4 A;  3F0B X;  3DL6 A;  4M6L A;  2QK8 A;  2D5N A;  4QJZ D;  1RX1 A;  2W3M A;  4IXG X;  2W3W A;  4HA9 A;  5HF2 X;  3FRA X;  3HJ3 A;  4QLG A;  1DR6 A;  3IX9 A;  3SRW X;  4KJJ A;  4H95 A;  3TQ8 A;  3JW3 A;  1RH3 A;  1HFP A;  2KGK A;  2ANO A;  1DRF A;  4ELH A;  4KY8 A;  3L3R A;  3QFX A;  3DG8 A;  4IXE D;  1RA8 A;  1YHO A;  3IRN A;  1DR7 A;  4P68 A;  7DFR A;  1IA4 A;  3JW5 A;  3GYF A;  4KY4 A;  4XT8 A;  4P3R A;  3LG4 A;  3QLY A;  1RE7 A;  5CCC A;  4RGC A;  3FQO A;  3CL9 A;  4H97 A;  1DG8 A;  4M7U A;  2W3V A;  3IA5 A;  1VDR A;  3SR5 X;  3EEM A;  3KFY A;  4KBN A;  3IRO A;  2GD9 A;  3QL3 A;  3F0U X;  3F8Z A;  1OHK A;  3QLW A;  2W9H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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