3SRWX

S. aureus dihydrofolate reductase complexed with novel 7-aryl-2,4-diaminoquinazolines
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
157
structure length
157
Chain Sequence
TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Staphylococcus aureus
molecule keywords Dihydrofolate reductase
total genus 41
structure length 157
sequence length 157
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2011-07-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3srwX00
4H95A 5HVEA 1PDBA 3SA2A 1RB3A 3QLSA 3EELA 1RB2A 2DRCA 1DRFA 2BLBA 1KMVA 4DPDA 3SRQX 3QGTA 3ROAA 3JW5A 3OAFA 4KYAA 3F91A 3M08A 3CD2A 3SAIA 4LAEX 3TQBA 1DR4A 3FYWX 3DRCA 5U26A 1DDSA 4Q0DA 3FRDX 2FZHA 3FS6A 2C2SA 3ZPCA 1DAJA 4KJKA 2FZIA 4XECX 2OIPA 3FL9A 4EIGA 1OHKA 3QFXA 1YHOA 3SA1A 1CZ3A 3K74A 4XT4A 3F0UX 4P66A 1RX2A 3NZBX 4ELBA 4PDJA 4ELHA 4KY8A 3D84X 4PSTA 3QG2A 1BOZA 1RA9A 3FRAX 4H97A 3ZPGA 2XW7A 5ECXA 4LAHX 5DFRA 1RX6A 3IROA 4EILA 2DHFA 3INVA 4G3MA 1RD7A 4M6LA 1RC4A 8DFRA 4KEBA 1DYJA 4OSGA 4QJZD 2CIGA 1RX1A 3CSEA 4RGCA 2D5NA 2ITHA 3GHCA 3KJRA 1JOMA 1DHFA 1J3JA 3UM8A 2AZNA 1RA3A 3NU0A 1PD8A 1DHIA 3TQAA 2ZZAA 3GYFA 4GH8A 4X5HA 4DFRA 3F0QX 3F0BX 2W3BA 1JUVA 5HF2X 3DG8A 3TD8A 3JVXA 3NZDA 4P3QA 3LG4A 3IA4A 3QLRA 4Q6AA 2QK8A 1BZFA 1DYRA 3KGYA 4IXFX 5CCCA 5HSUA 1VDRA 4ELEA 3NTZA 2LF1A 1RX9A 4PSYA 3K47A 3QLXA 1IA1A 2INQA 1DR3A 3OCHA 3Q1HA 2BLCA 7DFRA 5EAJA 4M6JA 2HM9A 1HFPA 4XRBA 3SRSX 2FZJA 3F0SX 4IXED 3JWFA 3UM5A 3S9UA 1DR7A 3CL9A 2ANOA 4M2XA 4IXGX 2W3AA 1QZFA 1M7AA 3FQOA 1S3VA 3I8AX 5JA3A 2KGKA 1IA2A 5HQYA 1OHJA 3QL0A 4PTHA 1M79A 1U71A 3RG9A 5JG0X 4FGGA 3NZAX 1DLRA 1KLKA 1DG5A 3QLYA 3QYLA 1DHJA 1MVTA 2ANQA 3IX9A 3RO9A 3EX8A 4CD2A 1LY3A 3NXXA 5FDAA 1U72A 3EIGA 4KAKA 1DIUA 1RE7A 3S3VA 5HUIA 1VJ3A 5HPBA 3KJSA 4KJJA 3EEMA 5ECCA 1J3IA 4X5JA 1RH3A 5HQZA 3FRBX 4XE6X 3NZ9X 4OR7A 3FQVA 3EEJA 4Q0EA 3QYOA 1DDRA 4HOFA 1RG7A 2W3VA 3QL3A 4P68A 3SH2A 3N0HA 3SGYA 3IA5A 4H96A 4P3RA 3NXVA 3S7AA 3SR5X 4KM2A 1DG8A 1M78A 3JSUA 4PSSA 3QLWA 6DFRA 4XT8A 4M6KA 1S3UA 2BL9A 5HI6A 3NZCX 3NZ6X 4G8ZX 3E0BA 1DR6A 1DRBA 2W9TA 3JWMA 1DYIA 4HOEA 4KBNA 4KM0A 1AO8A 3FL8A 4QLFA 1JOLA 1LUDA 3D80A 5DXVA 1S3WA 1DLSA 3UM6A 1CD2A 4XT7A 1IA4A 3M09A 4H98A 3DL6A 1DRAA 4QLGA 3TQ9A 3NXTA 5HF0X 3EEKA 4DDRA 2W3WA 4X5GA 4KNEA 4DPHA 3SRWX 4KLXA 2BLAA 4I1NA 3FQCA 1AI9A 4HA7A 4PTJA 3FYVX 3VCOA 1DREA 1S3YA 1HFQA 3NXYA 4TU5X 3QLZA 3F0XX 4KL9A 1RX3A 2W3MA 3KY8A 4KD7A 4FHBA 1DISA 1LY4A 2W9SA 3I3RA 5HT4A 4Q67A 4M7UA 2O7PA 1J3KA 4EIZA 1RA8A 3L3RA 2W9HA 4ECKA 3CLBA 1DR2A 4LEKX 1DRHA 1RA1A 5HT5A 3FQFA 3DGAA 1TDRA 4ELFA 3DL5A 4M7VA 1RX7A 3JWCA 3R33A 4QLEA 4LAGX 1DR1A 1RX8A 1U70A 3NRRA 4X5IA 4KFJA 3DFRA 1RF7A 2OBCA 4XT6A 3JW3A 1PD9A 2C2TA 1AOEA 3KFYA 1DF7A 3GHWA 1IA3A 2D0KA 5E8QA 3F8YA 2P4GA 3SQYX 4ELGA 2GD9A 4EJ1A 4HA9A 2HXVA 3K2HA 1RA2A 4DP3A 3FRFX 3FY8X 3FQZA 4QHVA 3SRRX 4XT5A 3IRNA 4G95A 3GHVA 2HQPA 3DAUA 2JYBA 1RX4A 3K45A 1RX5A 4KY4A 3SRUX 1DR5A 3F8ZA 3TQ8A 1KMSA 2G6VA 2B3ZA 2H2QA 3FREX 1E26A 3NXOA 1DG7A 5HVBA 4X5FA 3F0VX 3NXRA 1DYHA 4NX6A 5CC9A 3JTWA 1SEJA 4KJLA 4FGHA 1HFRA 1D1GA 3JWKA 4QI9A 5HSRA 3FY9X 4QJCA 3HJ3A 5U27A 2CD2A 3DATA 1ZDRA 3GI2A 4HOGA 2L28A 2W9GA 4I13A 3HBBA 4NX7A 1MVSA 3FQ0A 3IRMA
chains in the Genus database with same CATH superfamily
4H95A 5HVEA 1PDBA 3SA2A 1RB3A 3QLSA 3EELA 1RB2A 2DRCA 1DRFA 2BLBA 1KMVA 4DPDA 3SRQX 3QGTA 3ROAA 3JW5A 3OAFA 4KYAA 3F91A 3M08A 3CD2A 3SAIA 4LAEX 3TQBA 1DR4A 3FYWX 3DRCA 5U26A 1DDSA 4Q0DA 3FRDX 2FZHA 3FS6A 2C2SA 3ZPCA 1DAJA 4KJKA 2FZIA 4XECX 2OIPA 3FL9A 4EIGA 1OHKA 3QFXA 1YHOA 3SA1A 1CZ3A 3K74A 4XT4A 3F0UX 4P66A 1RX2A 3NZBX 4ELBA 4PDJA 4ELHA 4KY8A 3D84X 4PSTA 3QG2A 1BOZA 1RA9A 3FRAX 4H97A 3ZPGA 2XW7A 5ECXA 4LAHX 5DFRA 1RX6A 3IROA 4EILA 2DHFA 3INVA 4G3MA 1RD7A 4M6LA 1RC4A 8DFRA 4KEBA 1DYJA 4OSGA 4QJZD 2CIGA 1RX1A 3CSEA 4RGCA 2D5NA 2ITHA 3GHCA 3KJRA 1JOMA 1DHFA 1J3JA 3UM8A 2AZNA 1RA3A 3NU0A 1PD8A 1DHIA 3TQAA 2ZZAA 3GYFA 4GH8A 4X5HA 4DFRA 3F0QX 3F0BX 2W3BA 1JUVA 5HF2X 3DG8A 3TD8A 3JVXA 3NZDA 4P3QA 3LG4A 3IA4A 3QLRA 4Q6AA 2QK8A 1BZFA 1DYRA 3KGYA 4IXFX 5CCCA 5HSUA 1VDRA 4ELEA 3NTZA 2LF1A 1RX9A 4PSYA 3K47A 3QLXA 1IA1A 2INQA 1DR3A 3OCHA 3Q1HA 2BLCA 7DFRA 5EAJA 4M6JA 2HM9A 1HFPA 4XRBA 3SRSX 2FZJA 3F0SX 4IXED 3JWFA 3UM5A 3S9UA 1DR7A 3CL9A 2ANOA 4M2XA 4IXGX 2W3AA 1QZFA 1M7AA 3FQOA 1S3VA 3I8AX 5JA3A 2KGKA 1IA2A 5HQYA 1OHJA 3QL0A 4PTHA 1M79A 1U71A 3RG9A 5JG0X 4FGGA 3NZAX 1DLRA 1KLKA 1DG5A 3QLYA 3QYLA 1DHJA 1MVTA 2ANQA 3IX9A 3RO9A 3EX8A 4CD2A 1LY3A 3NXXA 5FDAA 1U72A 3EIGA 4KAKA 1DIUA 1RE7A 3S3VA 5HUIA 1VJ3A 5HPBA 3KJSA 4KJJA 3EEMA 5ECCA 1J3IA 4X5JA 1RH3A 5HQZA 3FRBX 4XE6X 3NZ9X 4OR7A 3FQVA 3EEJA 4Q0EA 3QYOA 1DDRA 4HOFA 1RG7A 2W3VA 3QL3A 4P68A 3SH2A 3N0HA 3SGYA 3IA5A 4H96A 4P3RA 3NXVA 3S7AA 3SR5X 4KM2A 1DG8A 1M78A 3JSUA 4PSSA 3QLWA 6DFRA 4XT8A 4M6KA 1S3UA 2BL9A 5HI6A 3NZCX 3NZ6X 4G8ZX 3E0BA 1DR6A 1DRBA 2W9TA 3JWMA 1DYIA 4HOEA 4KBNA 4KM0A 1AO8A 3FL8A 4QLFA 1JOLA 1LUDA 3D80A 5DXVA 1S3WA 1DLSA 3UM6A 1CD2A 4XT7A 1IA4A 3M09A 4H98A 3DL6A 1DRAA 4QLGA 3TQ9A 3NXTA 5HF0X 3EEKA 4DDRA 2W3WA 4X5GA 4KNEA 4DPHA 3SRWX 4KLXA 2BLAA 4I1NA 3FQCA 1AI9A 4HA7A 4PTJA 3FYVX 3VCOA 1DREA 1S3YA 1HFQA 3NXYA 4TU5X 3QLZA 3F0XX 4KL9A 1RX3A 2W3MA 3KY8A 4KD7A 4FHBA 1DISA 1LY4A 2W9SA 3I3RA 5HT4A 4Q67A 4M7UA 2O7PA 1J3KA 4EIZA 1RA8A 3L3RA 2W9HA 4ECKA 3CLBA 1DR2A 4LEKX 1DRHA 1RA1A 5HT5A 3FQFA 3DGAA 1TDRA 4ELFA 3DL5A 4M7VA 1RX7A 3JWCA 3R33A 4QLEA 4LAGX 1DR1A 1RX8A 1U70A 3NRRA 4X5IA 4KFJA 3DFRA 1RF7A 2OBCA 4XT6A 3JW3A 1PD9A 2C2TA 1AOEA 3KFYA 1DF7A 3GHWA 1IA3A 2D0KA 5E8QA 3F8YA 2P4GA 3SQYX 4ELGA 2GD9A 4EJ1A 4HA9A 2HXVA 3K2HA 1RA2A 4DP3A 3FRFX 3FY8X 3FQZA 4QHVA 3SRRX 4XT5A 3IRNA 4G95A 3GHVA 2HQPA 3DAUA 2JYBA 1RX4A 3K45A 1RX5A 4KY4A 3SRUX 1DR5A 3F8ZA 3TQ8A 1KMSA 2G6VA 2B3ZA 2H2QA 3FREX 1E26A 3NXOA 1DG7A 5HVBA 4X5FA 3F0VX 3NXRA 1DYHA 4NX6A 5CC9A 3JTWA 1SEJA 4KJLA 4FGHA 1HFRA 1D1GA 3JWKA 4QI9A 5HSRA 3FY9X 4QJCA 3HJ3A 5U27A 2CD2A 3DATA 1ZDRA 3GI2A 4HOGA 2L28A 2W9GA 4I13A 3HBBA 4NX7A 1MVSA 3FQ0A 3IRMA
chains in the Genus database with same CATH topology
4H95A 5HVEA 1PDBA 3SA2A 1RB3A 3QLSA 3EELA 1RB2A 2DRCA 1DRFA 2BLBA 1KMVA 4DPDA 3SRQX 3QGTA 3ROAA 3JW5A 3OAFA 4KYAA 3F91A 3M08A 3CD2A 3SAIA 4LAEX 3TQBA 1DR4A 3FYWX 3DRCA 5U26A 1DDSA 4Q0DA 3FRDX 2FZHA 3FS6A 2C2SA 3ZPCA 1DAJA 4KJKA 2FZIA 4XECX 2OIPA 3FL9A 4EIGA 1OHKA 3QFXA 1YHOA 3SA1A 1CZ3A 3K74A 4XT4A 3F0UX 4P66A 1RX2A 3NZBX 4ELBA 4PDJA 4ELHA 4KY8A 3D84X 4PSTA 3QG2A 1BOZA 1RA9A 3FRAX 4H97A 3ZPGA 2XW7A 5ECXA 4LAHX 5DFRA 1RX6A 3IROA 4EILA 2DHFA 3INVA 4G3MA 1RD7A 4M6LA 1RC4A 8DFRA 4KEBA 1DYJA 4OSGA 4QJZD 2CIGA 1RX1A 3CSEA 4RGCA 2D5NA 2ITHA 3GHCA 3KJRA 1JOMA 1DHFA 1J3JA 3UM8A 2AZNA 1RA3A 3NU0A 1PD8A 1DHIA 3TQAA 2ZZAA 3GYFA 4GH8A 4X5HA 4DFRA 3F0QX 3F0BX 2W3BA 1JUVA 5HF2X 3DG8A 3TD8A 3JVXA 3NZDA 4P3QA 3LG4A 3IA4A 3QLRA 4Q6AA 2QK8A 1BZFA 1DYRA 3KGYA 4IXFX 5CCCA 5HSUA 1VDRA 4ELEA 3NTZA 2LF1A 1RX9A 4PSYA 3K47A 3QLXA 1IA1A 2INQA 1DR3A 3OCHA 3Q1HA 2BLCA 7DFRA 5EAJA 4M6JA 2HM9A 1HFPA 4XRBA 3SRSX 2FZJA 3F0SX 4IXED 3JWFA 3UM5A 3S9UA 1DR7A 3CL9A 2ANOA 4M2XA 4IXGX 2W3AA 1QZFA 1M7AA 3FQOA 1S3VA 3I8AX 5JA3A 2KGKA 1IA2A 5HQYA 1OHJA 3QL0A 4PTHA 1M79A 1U71A 3RG9A 5JG0X 4FGGA 3NZAX 1DLRA 1KLKA 1DG5A 3QLYA 3QYLA 1DHJA 1MVTA 2ANQA 3IX9A 3RO9A 3EX8A 4CD2A 1LY3A 3NXXA 5FDAA 1U72A 3EIGA 4KAKA 1DIUA 1RE7A 3S3VA 5HUIA 1VJ3A 5HPBA 3KJSA 4KJJA 3EEMA 5ECCA 1J3IA 4X5JA 1RH3A 5HQZA 3FRBX 4XE6X 3NZ9X 4OR7A 3FQVA 3EEJA 4Q0EA 3QYOA 1DDRA 4HOFA 1RG7A 2W3VA 3QL3A 4P68A 3SH2A 3N0HA 3SGYA 3IA5A 4H96A 4P3RA 3NXVA 3S7AA 3SR5X 4KM2A 1DG8A 1M78A 3JSUA 4PSSA 3QLWA 6DFRA 4XT8A 4M6KA 1S3UA 2BL9A 5HI6A 3NZCX 3NZ6X 4G8ZX 3E0BA 1DR6A 1DRBA 2W9TA 3JWMA 1DYIA 4HOEA 4KBNA 4KM0A 1AO8A 3FL8A 4QLFA 1JOLA 1LUDA 3D80A 5DXVA 1S3WA 1DLSA 3UM6A 1CD2A 4XT7A 1IA4A 3M09A 4H98A 3DL6A 1DRAA 4QLGA 3TQ9A 3NXTA 5HF0X 3EEKA 4DDRA 2W3WA 4X5GA 4KNEA 4DPHA 3SRWX 4KLXA 2BLAA 4I1NA 3FQCA 1AI9A 4HA7A 4PTJA 3FYVX 3VCOA 1DREA 1S3YA 1HFQA 3NXYA 4TU5X 3QLZA 3F0XX 4KL9A 1RX3A 2W3MA 3KY8A 4KD7A 4FHBA 1DISA 1LY4A 2W9SA 3I3RA 5HT4A 4Q67A 4M7UA 2O7PA 1J3KA 4EIZA 1RA8A 3L3RA 2W9HA 4ECKA 3CLBA 1DR2A 4LEKX 1DRHA 1RA1A 5HT5A 3FQFA 3DGAA 1TDRA 4ELFA 3DL5A 4M7VA 1RX7A 3JWCA 3R33A 4QLEA 4LAGX 1DR1A 1RX8A 1U70A 3NRRA 4X5IA 4KFJA 3DFRA 1RF7A 2OBCA 4XT6A 3JW3A 1PD9A 2C2TA 1AOEA 3KFYA 1DF7A 3GHWA 1IA3A 2D0KA 5E8QA 3F8YA 2P4GA 3SQYX 4ELGA 2GD9A 4EJ1A 4HA9A 2HXVA 3K2HA 1RA2A 4DP3A 3FRFX 3FY8X 3FQZA 4QHVA 3SRRX 4XT5A 3IRNA 4G95A 3GHVA 2HQPA 3DAUA 2JYBA 1RX4A 3K45A 1RX5A 4KY4A 3SRUX 1DR5A 3F8ZA 3TQ8A 1KMSA 2G6VA 2B3ZA 2H2QA 3FREX 1E26A 3NXOA 1DG7A 5HVBA 4X5FA 3F0VX 3NXRA 1DYHA 4NX6A 5CC9A 3JTWA 1SEJA 4KJLA 4FGHA 1HFRA 1D1GA 3JWKA 4QI9A 5HSRA 3FY9X 4QJCA 3HJ3A 5U27A 2CD2A 3DATA 1ZDRA 3GI2A 4HOGA 2L28A 2W9GA 4I13A 3HBBA 4NX7A 1MVSA 3FQ0A 3IRMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4H95 A;  5HVE A;  1PDB A;  3SA2 A;  1RB3 A;  3QLS A;  3EEL A;  1RB2 A;  2DRC A;  1DRF A;  2BLB A;  1KMV A;  4DPD A;  3SRQ X;  3QGT A;  3ROA A;  3JW5 A;  3OAF A;  4KYA A;  3F91 A;  3M08 A;  3CD2 A;  3SAI A;  4LAE X;  3TQB A;  1DR4 A;  3FYW X;  3DRC A;  5U26 A;  1DDS A;  4Q0D A;  3FRD X;  2FZH A;  3FS6 A;  2C2S A;  3ZPC A;  1DAJ A;  4KJK A;  2FZI A;  4XEC X;  2OIP A;  3FL9 A;  4EIG A;  1OHK A;  3QFX A;  1YHO A;  3SA1 A;  1CZ3 A;  3K74 A;  4XT4 A;  3F0U X;  4P66 A;  1RX2 A;  3NZB X;  4ELB A;  4PDJ A;  4ELH A;  4KY8 A;  3D84 X;  4PST A;  3QG2 A;  1BOZ A;  1RA9 A;  3FRA X;  4H97 A;  3ZPG A;  2XW7 A;  5ECX A;  4LAH X;  5DFR A;  1RX6 A;  3IRO A;  4EIL A;  2DHF A;  3INV A;  4G3M A;  1RD7 A;  4M6L A;  1RC4 A;  8DFR A;  4KEB A;  1DYJ A;  4OSG A;  4QJZ D;  2CIG A;  1RX1 A;  3CSE A;  4RGC A;  2D5N A;  2ITH A;  3GHC A;  3KJR A;  1JOM A;  1DHF A;  1J3J A;  3UM8 A;  2AZN A;  1RA3 A;  3NU0 A;  1PD8 A;  1DHI A;  3TQA A;  2ZZA A;  3GYF A;  4GH8 A;  4X5H A;  4DFR A;  3F0Q X;  3F0B X;  2W3B A;  1JUV A;  5HF2 X;  3DG8 A;  3TD8 A;  3JVX A;  3NZD A;  4P3Q A;  3LG4 A;  3IA4 A;  3QLR A;  4Q6A A;  2QK8 A;  1BZF A;  1DYR A;  3KGY A;  4IXF X;  5CCC A;  5HSU A;  1VDR A;  4ELE A;  3NTZ A;  2LF1 A;  1RX9 A;  4PSY A;  3K47 A;  3QLX A;  1IA1 A;  2INQ A;  1DR3 A;  3OCH A;  3Q1H A;  2BLC A;  7DFR A;  5EAJ A;  4M6J A;  2HM9 A;  1HFP A;  4XRB A;  3SRS X;  2FZJ A;  3F0S X;  4IXE D;  3JWF A;  3UM5 A;  3S9U A;  1DR7 A;  3CL9 A;  2ANO A;  4M2X A;  4IXG X;  2W3A A;  1QZF A;  1M7A A;  3FQO A;  1S3V A;  3I8A X;  5JA3 A;  2KGK A;  1IA2 A;  5HQY A;  1OHJ A;  3QL0 A;  4PTH A;  1M79 A;  1U71 A;  3RG9 A;  5JG0 X;  4FGG A;  3NZA X;  1DLR A;  1KLK A;  1DG5 A;  3QLY A;  3QYL A;  1DHJ A;  1MVT A;  2ANQ A;  3IX9 A;  3RO9 A;  3EX8 A;  4CD2 A;  1LY3 A;  3NXX A;  5FDA A;  1U72 A;  3EIG A;  4KAK A;  1DIU A;  1RE7 A;  3S3V A;  5HUI A;  1VJ3 A;  5HPB A;  3KJS A;  4KJJ A;  3EEM A;  5ECC A;  1J3I A;  4X5J A;  1RH3 A;  5HQZ A;  3FRB X;  4XE6 X;  3NZ9 X;  4OR7 A;  3FQV A;  3EEJ A;  4Q0E A;  3QYO A;  1DDR A;  4HOF A;  1RG7 A;  2W3V A;  3QL3 A;  4P68 A;  3SH2 A;  3N0H A;  3SGY A;  3IA5 A;  4H96 A;  4P3R A;  3NXV A;  3S7A A;  3SR5 X;  4KM2 A;  1DG8 A;  1M78 A;  3JSU A;  4PSS A;  3QLW A;  6DFR A;  4XT8 A;  4M6K A;  1S3U A;  2BL9 A;  5HI6 A;  3NZC X;  3NZ6 X;  4G8Z X;  3E0B A;  1DR6 A;  1DRB A;  2W9T A;  3JWM A;  1DYI A;  4HOE A;  4KBN A;  4KM0 A;  1AO8 A;  3FL8 A;  4QLF A;  1JOL A;  1LUD A;  3D80 A;  5DXV A;  1S3W A;  1DLS A;  3UM6 A;  1CD2 A;  4XT7 A;  1IA4 A;  3M09 A;  4H98 A;  3DL6 A;  1DRA A;  4QLG A;  3TQ9 A;  3NXT A;  5HF0 X;  3EEK A;  4DDR A;  2W3W A;  4X5G A;  4KNE A;  4DPH A;  3SRW X;  4KLX A;  2BLA A;  4I1N A;  3FQC A;  1AI9 A;  4HA7 A;  4PTJ A;  3FYV X;  3VCO A;  1DRE A;  1S3Y A;  1HFQ A;  3NXY A;  4TU5 X;  3QLZ A;  3F0X X;  4KL9 A;  1RX3 A;  2W3M A;  3KY8 A;  4KD7 A;  4FHB A;  1DIS A;  1LY4 A;  2W9S A;  3I3R A;  5HT4 A;  4Q67 A;  4M7U A;  2O7P A;  1J3K A;  4EIZ A;  1RA8 A;  3L3R A;  2W9H A;  4ECK A;  3CLB A;  1DR2 A;  4LEK X;  1DRH A;  1RA1 A;  5HT5 A;  3FQF A;  3DGA A;  1TDR A;  4ELF A;  3DL5 A;  4M7V A;  1RX7 A;  3JWC A;  3R33 A;  4QLE A;  4LAG X;  1DR1 A;  1RX8 A;  1U70 A;  3NRR A;  4X5I A;  4KFJ A;  3DFR A;  1RF7 A;  2OBC A;  4XT6 A;  3JW3 A;  1PD9 A;  2C2T A;  1AOE A;  3KFY A;  1DF7 A;  3GHW A;  1IA3 A;  2D0K A;  5E8Q A;  3F8Y A;  2P4G A;  3SQY X;  4ELG A;  2GD9 A;  4EJ1 A;  4HA9 A;  2HXV A;  3K2H A;  1RA2 A;  4DP3 A;  3FRF X;  3FY8 X;  3FQZ A;  4QHV A;  3SRR X;  4XT5 A;  3IRN A;  4G95 A;  3GHV A;  2HQP A;  3DAU A;  2JYB A;  1RX4 A;  3K45 A;  1RX5 A;  4KY4 A;  3SRU X;  1DR5 A;  3F8Z A;  3TQ8 A;  1KMS A;  2G6V A;  2B3Z A;  2H2Q A;  3FRE X;  1E26 A;  3NXO A;  1DG7 A;  5HVB A;  4X5F A;  3F0V X;  3NXR A;  1DYH A;  4NX6 A;  5CC9 A;  3JTW A;  1SEJ A;  4KJL A;  4FGH A;  1HFR A;  1D1G A;  3JWK A;  4QI9 A;  5HSR A;  3FY9 X;  4QJC A;  3HJ3 A;  5U27 A;  2CD2 A;  3DAT A;  1ZDR A;  3GI2 A;  4HOG A;  2L28 A;  2W9G A;  4I13 A;  3HBB A;  4NX7 A;  1MVS A;  3FQ0 A;  3IRM A; 
#chains in the Genus database with same CATH topology
 4H95 A;  5HVE A;  1PDB A;  3SA2 A;  1RB3 A;  3QLS A;  3EEL A;  1RB2 A;  2DRC A;  1DRF A;  2BLB A;  1KMV A;  4DPD A;  3SRQ X;  3QGT A;  3ROA A;  3JW5 A;  3OAF A;  4KYA A;  3F91 A;  3M08 A;  3CD2 A;  3SAI A;  4LAE X;  3TQB A;  1DR4 A;  3FYW X;  3DRC A;  5U26 A;  1DDS A;  4Q0D A;  3FRD X;  2FZH A;  3FS6 A;  2C2S A;  3ZPC A;  1DAJ A;  4KJK A;  2FZI A;  4XEC X;  2OIP A;  3FL9 A;  4EIG A;  1OHK A;  3QFX A;  1YHO A;  3SA1 A;  1CZ3 A;  3K74 A;  4XT4 A;  3F0U X;  4P66 A;  1RX2 A;  3NZB X;  4ELB A;  4PDJ A;  4ELH A;  4KY8 A;  3D84 X;  4PST A;  3QG2 A;  1BOZ A;  1RA9 A;  3FRA X;  4H97 A;  3ZPG A;  2XW7 A;  5ECX A;  4LAH X;  5DFR A;  1RX6 A;  3IRO A;  4EIL A;  2DHF A;  3INV A;  4G3M A;  1RD7 A;  4M6L A;  1RC4 A;  8DFR A;  4KEB A;  1DYJ A;  4OSG A;  4QJZ D;  2CIG A;  1RX1 A;  3CSE A;  4RGC A;  2D5N A;  2ITH A;  3GHC A;  3KJR A;  1JOM A;  1DHF A;  1J3J A;  3UM8 A;  2AZN A;  1RA3 A;  3NU0 A;  1PD8 A;  1DHI A;  3TQA A;  2ZZA A;  3GYF A;  4GH8 A;  4X5H A;  4DFR A;  3F0Q X;  3F0B X;  2W3B A;  1JUV A;  5HF2 X;  3DG8 A;  3TD8 A;  3JVX A;  3NZD A;  4P3Q A;  3LG4 A;  3IA4 A;  3QLR A;  4Q6A A;  2QK8 A;  1BZF A;  1DYR A;  3KGY A;  4IXF X;  5CCC A;  5HSU A;  1VDR A;  4ELE A;  3NTZ A;  2LF1 A;  1RX9 A;  4PSY A;  3K47 A;  3QLX A;  1IA1 A;  2INQ A;  1DR3 A;  3OCH A;  3Q1H A;  2BLC A;  7DFR A;  5EAJ A;  4M6J A;  2HM9 A;  1HFP A;  4XRB A;  3SRS X;  2FZJ A;  3F0S X;  4IXE D;  3JWF A;  3UM5 A;  3S9U A;  1DR7 A;  3CL9 A;  2ANO A;  4M2X A;  4IXG X;  2W3A A;  1QZF A;  1M7A A;  3FQO A;  1S3V A;  3I8A X;  5JA3 A;  2KGK A;  1IA2 A;  5HQY A;  1OHJ A;  3QL0 A;  4PTH A;  1M79 A;  1U71 A;  3RG9 A;  5JG0 X;  4FGG A;  3NZA X;  1DLR A;  1KLK A;  1DG5 A;  3QLY A;  3QYL A;  1DHJ A;  1MVT A;  2ANQ A;  3IX9 A;  3RO9 A;  3EX8 A;  4CD2 A;  1LY3 A;  3NXX A;  5FDA A;  1U72 A;  3EIG A;  4KAK A;  1DIU A;  1RE7 A;  3S3V A;  5HUI A;  1VJ3 A;  5HPB A;  3KJS A;  4KJJ A;  3EEM A;  5ECC A;  1J3I A;  4X5J A;  1RH3 A;  5HQZ A;  3FRB X;  4XE6 X;  3NZ9 X;  4OR7 A;  3FQV A;  3EEJ A;  4Q0E A;  3QYO A;  1DDR A;  4HOF A;  1RG7 A;  2W3V A;  3QL3 A;  4P68 A;  3SH2 A;  3N0H A;  3SGY A;  3IA5 A;  4H96 A;  4P3R A;  3NXV A;  3S7A A;  3SR5 X;  4KM2 A;  1DG8 A;  1M78 A;  3JSU A;  4PSS A;  3QLW A;  6DFR A;  4XT8 A;  4M6K A;  1S3U A;  2BL9 A;  5HI6 A;  3NZC X;  3NZ6 X;  4G8Z X;  3E0B A;  1DR6 A;  1DRB A;  2W9T A;  3JWM A;  1DYI A;  4HOE A;  4KBN A;  4KM0 A;  1AO8 A;  3FL8 A;  4QLF A;  1JOL A;  1LUD A;  3D80 A;  5DXV A;  1S3W A;  1DLS A;  3UM6 A;  1CD2 A;  4XT7 A;  1IA4 A;  3M09 A;  4H98 A;  3DL6 A;  1DRA A;  4QLG A;  3TQ9 A;  3NXT A;  5HF0 X;  3EEK A;  4DDR A;  2W3W A;  4X5G A;  4KNE A;  4DPH A;  3SRW X;  4KLX A;  2BLA A;  4I1N A;  3FQC A;  1AI9 A;  4HA7 A;  4PTJ A;  3FYV X;  3VCO A;  1DRE A;  1S3Y A;  1HFQ A;  3NXY A;  4TU5 X;  3QLZ A;  3F0X X;  4KL9 A;  1RX3 A;  2W3M A;  3KY8 A;  4KD7 A;  4FHB A;  1DIS A;  1LY4 A;  2W9S A;  3I3R A;  5HT4 A;  4Q67 A;  4M7U A;  2O7P A;  1J3K A;  4EIZ A;  1RA8 A;  3L3R A;  2W9H A;  4ECK A;  3CLB A;  1DR2 A;  4LEK X;  1DRH A;  1RA1 A;  5HT5 A;  3FQF A;  3DGA A;  1TDR A;  4ELF A;  3DL5 A;  4M7V A;  1RX7 A;  3JWC A;  3R33 A;  4QLE A;  4LAG X;  1DR1 A;  1RX8 A;  1U70 A;  3NRR A;  4X5I A;  4KFJ A;  3DFR A;  1RF7 A;  2OBC A;  4XT6 A;  3JW3 A;  1PD9 A;  2C2T A;  1AOE A;  3KFY A;  1DF7 A;  3GHW A;  1IA3 A;  2D0K A;  5E8Q A;  3F8Y A;  2P4G A;  3SQY X;  4ELG A;  2GD9 A;  4EJ1 A;  4HA9 A;  2HXV A;  3K2H A;  1RA2 A;  4DP3 A;  3FRF X;  3FY8 X;  3FQZ A;  4QHV A;  3SRR X;  4XT5 A;  3IRN A;  4G95 A;  3GHV A;  2HQP A;  3DAU A;  2JYB A;  1RX4 A;  3K45 A;  1RX5 A;  4KY4 A;  3SRU X;  1DR5 A;  3F8Z A;  3TQ8 A;  1KMS A;  2G6V A;  2B3Z A;  2H2Q A;  3FRE X;  1E26 A;  3NXO A;  1DG7 A;  5HVB A;  4X5F A;  3F0V X;  3NXR A;  1DYH A;  4NX6 A;  5CC9 A;  3JTW A;  1SEJ A;  4KJL A;  4FGH A;  1HFR A;  1D1G A;  3JWK A;  4QI9 A;  5HSR A;  3FY9 X;  4QJC A;  3HJ3 A;  5U27 A;  2CD2 A;  3DAT A;  1ZDR A;  3GI2 A;  4HOG A;  2L28 A;  2W9G A;  4I13 A;  3HBB A;  4NX7 A;  1MVS A;  3FQ0 A;  3IRM A; 
#chains in the Genus database with same CATH homology
 4H95 A;  5HVE A;  1PDB A;  3SA2 A;  1RB3 A;  3QLS A;  3EEL A;  1RB2 A;  2DRC A;  1DRF A;  2BLB A;  1KMV A;  4DPD A;  3SRQ X;  3QGT A;  3ROA A;  3JW5 A;  3OAF A;  4KYA A;  3F91 A;  3M08 A;  3CD2 A;  3SAI A;  4LAE X;  3TQB A;  1DR4 A;  3FYW X;  3DRC A;  5U26 A;  1DDS A;  4Q0D A;  3FRD X;  2FZH A;  3FS6 A;  2C2S A;  3ZPC A;  1DAJ A;  4KJK A;  2FZI A;  4XEC X;  2OIP A;  3FL9 A;  4EIG A;  1OHK A;  3QFX A;  1YHO A;  3SA1 A;  1CZ3 A;  3K74 A;  4XT4 A;  3F0U X;  4P66 A;  1RX2 A;  3NZB X;  4ELB A;  4PDJ A;  4ELH A;  4KY8 A;  3D84 X;  4PST A;  3QG2 A;  1BOZ A;  1RA9 A;  3FRA X;  4H97 A;  3ZPG A;  2XW7 A;  5ECX A;  4LAH X;  5DFR A;  1RX6 A;  3IRO A;  4EIL A;  2DHF A;  3INV A;  4G3M A;  1RD7 A;  4M6L A;  1RC4 A;  8DFR A;  4KEB A;  1DYJ A;  4OSG A;  4QJZ D;  2CIG A;  1RX1 A;  3CSE A;  4RGC A;  2D5N A;  2ITH A;  3GHC A;  3KJR A;  1JOM A;  1DHF A;  1J3J A;  3UM8 A;  2AZN A;  1RA3 A;  3NU0 A;  1PD8 A;  1DHI A;  3TQA A;  2ZZA A;  3GYF A;  4GH8 A;  4X5H A;  4DFR A;  3F0Q X;  3F0B X;  2W3B A;  1JUV A;  5HF2 X;  3DG8 A;  3TD8 A;  3JVX A;  3NZD A;  4P3Q A;  3LG4 A;  3IA4 A;  3QLR A;  4Q6A A;  2QK8 A;  1BZF A;  1DYR A;  3KGY A;  4IXF X;  5CCC A;  5HSU A;  1VDR A;  4ELE A;  3NTZ A;  2LF1 A;  1RX9 A;  4PSY A;  3K47 A;  3QLX A;  1IA1 A;  2INQ A;  1DR3 A;  3OCH A;  3Q1H A;  2BLC A;  7DFR A;  5EAJ A;  4M6J A;  2HM9 A;  1HFP A;  4XRB A;  3SRS X;  2FZJ A;  3F0S X;  4IXE D;  3JWF A;  3UM5 A;  3S9U A;  1DR7 A;  3CL9 A;  2ANO A;  4M2X A;  4IXG X;  2W3A A;  1QZF A;  1M7A A;  3FQO A;  1S3V A;  3I8A X;  5JA3 A;  2KGK A;  1IA2 A;  5HQY A;  1OHJ A;  3QL0 A;  4PTH A;  1M79 A;  1U71 A;  3RG9 A;  5JG0 X;  4FGG A;  3NZA X;  1DLR A;  1KLK A;  1DG5 A;  3QLY A;  3QYL A;  1DHJ A;  1MVT A;  2ANQ A;  3IX9 A;  3RO9 A;  3EX8 A;  4CD2 A;  1LY3 A;  3NXX A;  5FDA A;  1U72 A;  3EIG A;  4KAK A;  1DIU A;  1RE7 A;  3S3V A;  5HUI A;  1VJ3 A;  5HPB A;  3KJS A;  4KJJ A;  3EEM A;  5ECC A;  1J3I A;  4X5J A;  1RH3 A;  5HQZ A;  3FRB X;  4XE6 X;  3NZ9 X;  4OR7 A;  3FQV A;  3EEJ A;  4Q0E A;  3QYO A;  1DDR A;  4HOF A;  1RG7 A;  2W3V A;  3QL3 A;  4P68 A;  3SH2 A;  3N0H A;  3SGY A;  3IA5 A;  4H96 A;  4P3R A;  3NXV A;  3S7A A;  3SR5 X;  4KM2 A;  1DG8 A;  1M78 A;  3JSU A;  4PSS A;  3QLW A;  6DFR A;  4XT8 A;  4M6K A;  1S3U A;  2BL9 A;  5HI6 A;  3NZC X;  3NZ6 X;  4G8Z X;  3E0B A;  1DR6 A;  1DRB A;  2W9T A;  3JWM A;  1DYI A;  4HOE A;  4KBN A;  4KM0 A;  1AO8 A;  3FL8 A;  4QLF A;  1JOL A;  1LUD A;  3D80 A;  5DXV A;  1S3W A;  1DLS A;  3UM6 A;  1CD2 A;  4XT7 A;  1IA4 A;  3M09 A;  4H98 A;  3DL6 A;  1DRA A;  4QLG A;  3TQ9 A;  3NXT A;  5HF0 X;  3EEK A;  4DDR A;  2W3W A;  4X5G A;  4KNE A;  4DPH A;  3SRW X;  4KLX A;  2BLA A;  4I1N A;  3FQC A;  1AI9 A;  4HA7 A;  4PTJ A;  3FYV X;  3VCO A;  1DRE A;  1S3Y A;  1HFQ A;  3NXY A;  4TU5 X;  3QLZ A;  3F0X X;  4KL9 A;  1RX3 A;  2W3M A;  3KY8 A;  4KD7 A;  4FHB A;  1DIS A;  1LY4 A;  2W9S A;  3I3R A;  5HT4 A;  4Q67 A;  4M7U A;  2O7P A;  1J3K A;  4EIZ A;  1RA8 A;  3L3R A;  2W9H A;  4ECK A;  3CLB A;  1DR2 A;  4LEK X;  1DRH A;  1RA1 A;  5HT5 A;  3FQF A;  3DGA A;  1TDR A;  4ELF A;  3DL5 A;  4M7V A;  1RX7 A;  3JWC A;  3R33 A;  4QLE A;  4LAG X;  1DR1 A;  1RX8 A;  1U70 A;  3NRR A;  4X5I A;  4KFJ A;  3DFR A;  1RF7 A;  2OBC A;  4XT6 A;  3JW3 A;  1PD9 A;  2C2T A;  1AOE A;  3KFY A;  1DF7 A;  3GHW A;  1IA3 A;  2D0K A;  5E8Q A;  3F8Y A;  2P4G A;  3SQY X;  4ELG A;  2GD9 A;  4EJ1 A;  4HA9 A;  2HXV A;  3K2H A;  1RA2 A;  4DP3 A;  3FRF X;  3FY8 X;  3FQZ A;  4QHV A;  3SRR X;  4XT5 A;  3IRN A;  4G95 A;  3GHV A;  2HQP A;  3DAU A;  2JYB A;  1RX4 A;  3K45 A;  1RX5 A;  4KY4 A;  3SRU X;  1DR5 A;  3F8Z A;  3TQ8 A;  1KMS A;  2G6V A;  2B3Z A;  2H2Q A;  3FRE X;  1E26 A;  3NXO A;  1DG7 A;  5HVB A;  4X5F A;  3F0V X;  3NXR A;  1DYH A;  4NX6 A;  5CC9 A;  3JTW A;  1SEJ A;  4KJL A;  4FGH A;  1HFR A;  1D1G A;  3JWK A;  4QI9 A;  5HSR A;  3FY9 X;  4QJC A;  3HJ3 A;  5U27 A;  2CD2 A;  3DAT A;  1ZDR A;  3GI2 A;  4HOG A;  2L28 A;  2W9G A;  4I13 A;  3HBB A;  4NX7 A;  1MVS A;  3FQ0 A;  3IRM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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