4ELGA

Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
166
structure length
166
Chain Sequence
MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Bacillus anthracis
publication title Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase.
pubmed doi rcsb
molecule keywords Dihydrofolate reductase
total genus 40
structure length 166
sequence length 166
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2012-04-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4elgA00
3EEMA 3DFRA 3OCHA 4KD7A 3OAFA 3FRBX 3GI2A 1U72A 4M6KA 4KJKA 5HI6A 3SR5X 4KAKA 4ELGA 3QLRA 2AZNA 1PD8A 3TQAA 4NX6A 4OR7A 4P3RA 2BL9A 3JWKA 3NTZA 1DDRA 3FQOA 4G3MA 4LAHX 4QHVA 5HPBA 5ECCA 3NRRA 5U26A 2HM9A 1U71A 2W3WA 4X5IA 1DR7A 3K45A 2ZZAA 5HT4A 1DHIA 3QG2A 4ELBA 4M7UA 3JWMA 4H97A 4Q67A 3E0BA 4M7VA 3SRUX 3RG9A 1RB2A 2HXVA 3TQ9A 4HA7A 3HBBA 2D5NA 3NXRA 1M78A 1S3VA 1RF7A 1RX5A 4KLXA 1M7AA 4QJZD 3UM6A 1MVSA 1LY4A 4XT5A 4EIGA 3SRRX 1S3YA 4XT4A 3D80A 3TQ8A 1DLRA 5CCCA 4XT8A 4DP3A 4LEKX 4KJLA 3FL8A 4FGGA 4KL9A 3GYFA 4GH8A 1AO8A 4Q0EA 5HVEA 3IRNA 3F0QX 4X5GA 3IA4A 5HVBA 3IROA 2OBCA 3K2HA 3DGAA 3SAIA 3KFYA 1AI9A 3F8ZA 3CLBA 4KJJA 1DLSA 1JUVA 4I13A 3ROAA 3QFXA 1DHFA 3I8AX 4Q0DA 1DF7A 4KBNA 6DFRA 5HQYA 3Q1HA 3F0XX 4KM2A 3QYLA 3FYWX 1MVTA 2INQA 2DHFA 1DRHA 1DR6A 1IA1A 4M2XA 1RX8A 3ZPCA 4PTJA 3EX8A 1RX9A 2C2SA 1DR2A 1IA4A 3NXVA 2W3BA 3FL9A 3JTWA 3DL6A 3S9UA 1DDSA 4PTHA 4XE6X 4EIZA 4KY8A 4H98A 1DRAA 4CD2A 1KMVA 1S3WA 1DR1A 2QK8A 3I3RA 3QLWA 1AOEA 1DREA 1DR5A 3F0UX 3CSEA 1DG5A 3JVXA 1OHJA 1DISA 1HFPA 1KMSA 3GHWA 3NZ9X 2W9HA 3JSUA 3QL0A 1DIUA 3F8YA 3NXYA 5HSRA 1PDBA 3S7AA 3QLXA 3SGYA 5HQZA 3NXOA 2ANQA 3SA1A 4X5FA 4HOEA 4G95A 4KYAA 2C2TA 3CL9A 2P4GA 1RX7A 1LY3A 3M08A 3K74A 4LAGX 4M6LA 4IXED 3DL5A 4KY4A 1JOMA 1D1GA 8DFRA 4PSYA 4XRBA 5ECXA 5HF2X 1VJ3A 1RH3A 1DR4A 4QLEA 1CD2A 4DDRA 4X5HA 1VDRA 4ELEA 2LF1A 3FQZA 1RX4A 1HFQA 1J3KA 3JW5A 3LG4A 1HFRA 3F0SX 4X5JA 3S3VA 3DG8A 2L28A 4XECX 3FRFX 3FQ0A 1DYRA 3SRQX 1S3UA 1OHKA 1YHOA 1SEJA 3D84X 5JG0X 2FZHA 1RX2A 1IA2A 1DG8A 3KJRA 4QI9A 3NU0A 3FQFA 2G6VA 1DYJA 5FDAA 3QLSA 4IXFX 4Q6AA 3GHCA 3NZ6X 2FZJA 1RA2A 1DHJA 3INVA 4G8ZX 3QLZA 1RX6A 5DXVA 2BLBA 3N0HA 4EILA 2GD9A 2W3VA 1RA1A 4NX7A 2BLAA 3NZDA 3ZPGA 3HJ3A 4I1NA 2OIPA 3FRAX 1DR3A 1M79A 2ITHA 1BZFA 4QLGA 4RGCA 3K47A 3SA2A 3FRDX 3VCOA 1U70A 3NZBX 1KLKA 3TD8A 4KEBA 1DRBA 4DPHA 2O7PA 4FGHA 4KFJA 3FREX 3SQYX 2CD2A 3FY9X 7DFRA 4P3QA 3R33A 4QLFA 2W9SA 3FQCA 1CZ3A 2KGKA 3CD2A 1RA9A 3TQBA 3FQVA 4ELHA 2W3MA 3SRWX 3DATA 3EIGA 3QLYA 3FY8X 5EAJA 2JYBA 4HOGA 4DPDA 2FZIA 4HOFA 3SRSX 1DRFA 2W9TA 3KY8A 2H2QA 3QGTA 3L3RA 1DYIA 1RA3A 3JWFA 4HA9A 4H96A 3IRMA 3UM8A 3IX9A 2HQPA 1RG7A 1J3JA 1RX1A 4XT7A 3UM5A 1RC4A 4M6JA 3DAUA 3KJSA 1DAJA 1RX3A 4PDJA 1BOZA 5E8QA 4FHBA 1J3IA 3M09A 4ELFA 1RA8A 1RE7A 4KNEA 4PSSA 4OSGA 1E26A 1QZFA 3F91A 2D0KA 1ZDRA 4TU5X 5U27A 4KM0A 1TDRA 1PD9A 3NXXA 5JA3A 3F0VX 3F0BX 2B3ZA 3JW3A 1JOLA 2W9GA 3NXTA 1LUDA 2ANOA 3SH2A 3NZAX 1IA3A 2CIGA 1RD7A 3DRCA 4QJCA 5CC9A 3GHVA 4PSTA 5HT5A 3EELA 4P66A 4DFRA 3FS6A 2XW7A 3JWCA 4IXGX 4EJ1A 5HUIA 3NZCX 3EEKA 4P68A 1DYHA 4H95A 3QYOA 4XT6A 2BLCA 1DG7A 3KGYA 5HF0X 3EEJA 3IA5A 3QL3A 5DFRA 5HSUA 2W3AA 1RB3A 3RO9A 2DRCA 4LAEX 4ECKA 3FYVX
chains in the Genus database with same CATH superfamily
3EEMA 3DFRA 3OCHA 4KD7A 3OAFA 3FRBX 3GI2A 1U72A 4M6KA 4KJKA 5HI6A 3SR5X 4KAKA 4ELGA 3QLRA 2AZNA 1PD8A 3TQAA 4NX6A 4OR7A 4P3RA 2BL9A 3JWKA 3NTZA 1DDRA 3FQOA 4G3MA 4LAHX 4QHVA 5HPBA 5ECCA 3NRRA 5U26A 2HM9A 1U71A 2W3WA 4X5IA 1DR7A 3K45A 2ZZAA 5HT4A 1DHIA 3QG2A 4ELBA 4M7UA 3JWMA 4H97A 4Q67A 3E0BA 4M7VA 3SRUX 3RG9A 1RB2A 2HXVA 3TQ9A 4HA7A 3HBBA 2D5NA 3NXRA 1M78A 1S3VA 1RF7A 1RX5A 4KLXA 1M7AA 4QJZD 3UM6A 1MVSA 1LY4A 4XT5A 4EIGA 3SRRX 1S3YA 4XT4A 3D80A 3TQ8A 1DLRA 5CCCA 4XT8A 4DP3A 4LEKX 4KJLA 3FL8A 4FGGA 4KL9A 3GYFA 4GH8A 1AO8A 4Q0EA 5HVEA 3IRNA 3F0QX 4X5GA 3IA4A 5HVBA 3IROA 2OBCA 3K2HA 3DGAA 3SAIA 3KFYA 1AI9A 3F8ZA 3CLBA 4KJJA 1DLSA 1JUVA 4I13A 3ROAA 3QFXA 1DHFA 3I8AX 4Q0DA 1DF7A 4KBNA 6DFRA 5HQYA 3Q1HA 3F0XX 4KM2A 3QYLA 3FYWX 1MVTA 2INQA 2DHFA 1DRHA 1DR6A 1IA1A 4M2XA 1RX8A 3ZPCA 4PTJA 3EX8A 1RX9A 2C2SA 1DR2A 1IA4A 3NXVA 2W3BA 3FL9A 3JTWA 3DL6A 3S9UA 1DDSA 4PTHA 4XE6X 4EIZA 4KY8A 4H98A 1DRAA 4CD2A 1KMVA 1S3WA 1DR1A 2QK8A 3I3RA 3QLWA 1AOEA 1DREA 1DR5A 3F0UX 3CSEA 1DG5A 3JVXA 1OHJA 1DISA 1HFPA 1KMSA 3GHWA 3NZ9X 2W9HA 3JSUA 3QL0A 1DIUA 3F8YA 3NXYA 5HSRA 1PDBA 3S7AA 3QLXA 3SGYA 5HQZA 3NXOA 2ANQA 3SA1A 4X5FA 4HOEA 4G95A 4KYAA 2C2TA 3CL9A 2P4GA 1RX7A 1LY3A 3M08A 3K74A 4LAGX 4M6LA 4IXED 3DL5A 4KY4A 1JOMA 1D1GA 8DFRA 4PSYA 4XRBA 5ECXA 5HF2X 1VJ3A 1RH3A 1DR4A 4QLEA 1CD2A 4DDRA 4X5HA 1VDRA 4ELEA 2LF1A 3FQZA 1RX4A 1HFQA 1J3KA 3JW5A 3LG4A 1HFRA 3F0SX 4X5JA 3S3VA 3DG8A 2L28A 4XECX 3FRFX 3FQ0A 1DYRA 3SRQX 1S3UA 1OHKA 1YHOA 1SEJA 3D84X 5JG0X 2FZHA 1RX2A 1IA2A 1DG8A 3KJRA 4QI9A 3NU0A 3FQFA 2G6VA 1DYJA 5FDAA 3QLSA 4IXFX 4Q6AA 3GHCA 3NZ6X 2FZJA 1RA2A 1DHJA 3INVA 4G8ZX 3QLZA 1RX6A 5DXVA 2BLBA 3N0HA 4EILA 2GD9A 2W3VA 1RA1A 4NX7A 2BLAA 3NZDA 3ZPGA 3HJ3A 4I1NA 2OIPA 3FRAX 1DR3A 1M79A 2ITHA 1BZFA 4QLGA 4RGCA 3K47A 3SA2A 3FRDX 3VCOA 1U70A 3NZBX 1KLKA 3TD8A 4KEBA 1DRBA 4DPHA 2O7PA 4FGHA 4KFJA 3FREX 3SQYX 2CD2A 3FY9X 7DFRA 4P3QA 3R33A 4QLFA 2W9SA 3FQCA 1CZ3A 2KGKA 3CD2A 1RA9A 3TQBA 3FQVA 4ELHA 2W3MA 3SRWX 3DATA 3EIGA 3QLYA 3FY8X 5EAJA 2JYBA 4HOGA 4DPDA 2FZIA 4HOFA 3SRSX 1DRFA 2W9TA 3KY8A 2H2QA 3QGTA 3L3RA 1DYIA 1RA3A 3JWFA 4HA9A 4H96A 3IRMA 3UM8A 3IX9A 2HQPA 1RG7A 1J3JA 1RX1A 4XT7A 3UM5A 1RC4A 4M6JA 3DAUA 3KJSA 1DAJA 1RX3A 4PDJA 1BOZA 5E8QA 4FHBA 1J3IA 3M09A 4ELFA 1RA8A 1RE7A 4KNEA 4PSSA 4OSGA 1E26A 1QZFA 3F91A 2D0KA 1ZDRA 4TU5X 5U27A 4KM0A 1TDRA 1PD9A 3NXXA 5JA3A 3F0VX 3F0BX 2B3ZA 3JW3A 1JOLA 2W9GA 3NXTA 1LUDA 2ANOA 3SH2A 3NZAX 1IA3A 2CIGA 1RD7A 3DRCA 4QJCA 5CC9A 3GHVA 4PSTA 5HT5A 3EELA 4P66A 4DFRA 3FS6A 2XW7A 3JWCA 4IXGX 4EJ1A 5HUIA 3NZCX 3EEKA 4P68A 1DYHA 4H95A 3QYOA 4XT6A 2BLCA 1DG7A 3KGYA 5HF0X 3EEJA 3IA5A 3QL3A 5DFRA 5HSUA 2W3AA 1RB3A 3RO9A 2DRCA 4LAEX 4ECKA 3FYVX
chains in the Genus database with same CATH topology
3EEMA 3DFRA 3OCHA 4KD7A 3OAFA 3FRBX 3GI2A 1U72A 4M6KA 4KJKA 5HI6A 3SR5X 4KAKA 4ELGA 3QLRA 2AZNA 1PD8A 3TQAA 4NX6A 4OR7A 4P3RA 2BL9A 3JWKA 3NTZA 1DDRA 3FQOA 4G3MA 4LAHX 4QHVA 5HPBA 5ECCA 3NRRA 5U26A 2HM9A 1U71A 2W3WA 4X5IA 1DR7A 3K45A 2ZZAA 5HT4A 1DHIA 3QG2A 4ELBA 4M7UA 3JWMA 4H97A 4Q67A 3E0BA 4M7VA 3SRUX 3RG9A 1RB2A 2HXVA 3TQ9A 4HA7A 3HBBA 2D5NA 3NXRA 1M78A 1S3VA 1RF7A 1RX5A 4KLXA 1M7AA 4QJZD 3UM6A 1MVSA 1LY4A 4XT5A 4EIGA 3SRRX 1S3YA 4XT4A 3D80A 3TQ8A 1DLRA 5CCCA 4XT8A 4DP3A 4LEKX 4KJLA 3FL8A 4FGGA 4KL9A 3GYFA 4GH8A 1AO8A 4Q0EA 5HVEA 3IRNA 3F0QX 4X5GA 3IA4A 5HVBA 3IROA 2OBCA 3K2HA 3DGAA 3SAIA 3KFYA 1AI9A 3F8ZA 3CLBA 4KJJA 1DLSA 1JUVA 4I13A 3ROAA 3QFXA 1DHFA 3I8AX 4Q0DA 1DF7A 4KBNA 6DFRA 5HQYA 3Q1HA 3F0XX 4KM2A 3QYLA 3FYWX 1MVTA 2INQA 2DHFA 1DRHA 1DR6A 1IA1A 4M2XA 1RX8A 3ZPCA 4PTJA 3EX8A 1RX9A 2C2SA 1DR2A 1IA4A 3NXVA 2W3BA 3FL9A 3JTWA 3DL6A 3S9UA 1DDSA 4PTHA 4XE6X 4EIZA 4KY8A 4H98A 1DRAA 4CD2A 1KMVA 1S3WA 1DR1A 2QK8A 3I3RA 3QLWA 1AOEA 1DREA 1DR5A 3F0UX 3CSEA 1DG5A 3JVXA 1OHJA 1DISA 1HFPA 1KMSA 3GHWA 3NZ9X 2W9HA 3JSUA 3QL0A 1DIUA 3F8YA 3NXYA 5HSRA 1PDBA 3S7AA 3QLXA 3SGYA 5HQZA 3NXOA 2ANQA 3SA1A 4X5FA 4HOEA 4G95A 4KYAA 2C2TA 3CL9A 2P4GA 1RX7A 1LY3A 3M08A 3K74A 4LAGX 4M6LA 4IXED 3DL5A 4KY4A 1JOMA 1D1GA 8DFRA 4PSYA 4XRBA 5ECXA 5HF2X 1VJ3A 1RH3A 1DR4A 4QLEA 1CD2A 4DDRA 4X5HA 1VDRA 4ELEA 2LF1A 3FQZA 1RX4A 1HFQA 1J3KA 3JW5A 3LG4A 1HFRA 3F0SX 4X5JA 3S3VA 3DG8A 2L28A 4XECX 3FRFX 3FQ0A 1DYRA 3SRQX 1S3UA 1OHKA 1YHOA 1SEJA 3D84X 5JG0X 2FZHA 1RX2A 1IA2A 1DG8A 3KJRA 4QI9A 3NU0A 3FQFA 2G6VA 1DYJA 5FDAA 3QLSA 4IXFX 4Q6AA 3GHCA 3NZ6X 2FZJA 1RA2A 1DHJA 3INVA 4G8ZX 3QLZA 1RX6A 5DXVA 2BLBA 3N0HA 4EILA 2GD9A 2W3VA 1RA1A 4NX7A 2BLAA 3NZDA 3ZPGA 3HJ3A 4I1NA 2OIPA 3FRAX 1DR3A 1M79A 2ITHA 1BZFA 4QLGA 4RGCA 3K47A 3SA2A 3FRDX 3VCOA 1U70A 3NZBX 1KLKA 3TD8A 4KEBA 1DRBA 4DPHA 2O7PA 4FGHA 4KFJA 3FREX 3SQYX 2CD2A 3FY9X 7DFRA 4P3QA 3R33A 4QLFA 2W9SA 3FQCA 1CZ3A 2KGKA 3CD2A 1RA9A 3TQBA 3FQVA 4ELHA 2W3MA 3SRWX 3DATA 3EIGA 3QLYA 3FY8X 5EAJA 2JYBA 4HOGA 4DPDA 2FZIA 4HOFA 3SRSX 1DRFA 2W9TA 3KY8A 2H2QA 3QGTA 3L3RA 1DYIA 1RA3A 3JWFA 4HA9A 4H96A 3IRMA 3UM8A 3IX9A 2HQPA 1RG7A 1J3JA 1RX1A 4XT7A 3UM5A 1RC4A 4M6JA 3DAUA 3KJSA 1DAJA 1RX3A 4PDJA 1BOZA 5E8QA 4FHBA 1J3IA 3M09A 4ELFA 1RA8A 1RE7A 4KNEA 4PSSA 4OSGA 1E26A 1QZFA 3F91A 2D0KA 1ZDRA 4TU5X 5U27A 4KM0A 1TDRA 1PD9A 3NXXA 5JA3A 3F0VX 3F0BX 2B3ZA 3JW3A 1JOLA 2W9GA 3NXTA 1LUDA 2ANOA 3SH2A 3NZAX 1IA3A 2CIGA 1RD7A 3DRCA 4QJCA 5CC9A 3GHVA 4PSTA 5HT5A 3EELA 4P66A 4DFRA 3FS6A 2XW7A 3JWCA 4IXGX 4EJ1A 5HUIA 3NZCX 3EEKA 4P68A 1DYHA 4H95A 3QYOA 4XT6A 2BLCA 1DG7A 3KGYA 5HF0X 3EEJA 3IA5A 3QL3A 5DFRA 5HSUA 2W3AA 1RB3A 3RO9A 2DRCA 4LAEX 4ECKA 3FYVX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EEM A;  3DFR A;  3OCH A;  4KD7 A;  3OAF A;  3FRB X;  3GI2 A;  1U72 A;  4M6K A;  4KJK A;  5HI6 A;  3SR5 X;  4KAK A;  4ELG A;  3QLR A;  2AZN A;  1PD8 A;  3TQA A;  4NX6 A;  4OR7 A;  4P3R A;  2BL9 A;  3JWK A;  3NTZ A;  1DDR A;  3FQO A;  4G3M A;  4LAH X;  4QHV A;  5HPB A;  5ECC A;  3NRR A;  5U26 A;  2HM9 A;  1U71 A;  2W3W A;  4X5I A;  1DR7 A;  3K45 A;  2ZZA A;  5HT4 A;  1DHI A;  3QG2 A;  4ELB A;  4M7U A;  3JWM A;  4H97 A;  4Q67 A;  3E0B A;  4M7V A;  3SRU X;  3RG9 A;  1RB2 A;  2HXV A;  3TQ9 A;  4HA7 A;  3HBB A;  2D5N A;  3NXR A;  1M78 A;  1S3V A;  1RF7 A;  1RX5 A;  4KLX A;  1M7A A;  4QJZ D;  3UM6 A;  1MVS A;  1LY4 A;  4XT5 A;  4EIG A;  3SRR X;  1S3Y A;  4XT4 A;  3D80 A;  3TQ8 A;  1DLR A;  5CCC A;  4XT8 A;  4DP3 A;  4LEK X;  4KJL A;  3FL8 A;  4FGG A;  4KL9 A;  3GYF A;  4GH8 A;  1AO8 A;  4Q0E A;  5HVE A;  3IRN A;  3F0Q X;  4X5G A;  3IA4 A;  5HVB A;  3IRO A;  2OBC A;  3K2H A;  3DGA A;  3SAI A;  3KFY A;  1AI9 A;  3F8Z A;  3CLB A;  4KJJ A;  1DLS A;  1JUV A;  4I13 A;  3ROA A;  3QFX A;  1DHF A;  3I8A X;  4Q0D A;  1DF7 A;  4KBN A;  6DFR A;  5HQY A;  3Q1H A;  3F0X X;  4KM2 A;  3QYL A;  3FYW X;  1MVT A;  2INQ A;  2DHF A;  1DRH A;  1DR6 A;  1IA1 A;  4M2X A;  1RX8 A;  3ZPC A;  4PTJ A;  3EX8 A;  1RX9 A;  2C2S A;  1DR2 A;  1IA4 A;  3NXV A;  2W3B A;  3FL9 A;  3JTW A;  3DL6 A;  3S9U A;  1DDS A;  4PTH A;  4XE6 X;  4EIZ A;  4KY8 A;  4H98 A;  1DRA A;  4CD2 A;  1KMV A;  1S3W A;  1DR1 A;  2QK8 A;  3I3R A;  3QLW A;  1AOE A;  1DRE A;  1DR5 A;  3F0U X;  3CSE A;  1DG5 A;  3JVX A;  1OHJ A;  1DIS A;  1HFP A;  1KMS A;  3GHW A;  3NZ9 X;  2W9H A;  3JSU A;  3QL0 A;  1DIU A;  3F8Y A;  3NXY A;  5HSR A;  1PDB A;  3S7A A;  3QLX A;  3SGY A;  5HQZ A;  3NXO A;  2ANQ A;  3SA1 A;  4X5F A;  4HOE A;  4G95 A;  4KYA A;  2C2T A;  3CL9 A;  2P4G A;  1RX7 A;  1LY3 A;  3M08 A;  3K74 A;  4LAG X;  4M6L A;  4IXE D;  3DL5 A;  4KY4 A;  1JOM A;  1D1G A;  8DFR A;  4PSY A;  4XRB A;  5ECX A;  5HF2 X;  1VJ3 A;  1RH3 A;  1DR4 A;  4QLE A;  1CD2 A;  4DDR A;  4X5H A;  1VDR A;  4ELE A;  2LF1 A;  3FQZ A;  1RX4 A;  1HFQ A;  1J3K A;  3JW5 A;  3LG4 A;  1HFR A;  3F0S X;  4X5J A;  3S3V A;  3DG8 A;  2L28 A;  4XEC X;  3FRF X;  3FQ0 A;  1DYR A;  3SRQ X;  1S3U A;  1OHK A;  1YHO A;  1SEJ A;  3D84 X;  5JG0 X;  2FZH A;  1RX2 A;  1IA2 A;  1DG8 A;  3KJR A;  4QI9 A;  3NU0 A;  3FQF A;  2G6V A;  1DYJ A;  5FDA A;  3QLS A;  4IXF X;  4Q6A A;  3GHC A;  3NZ6 X;  2FZJ A;  1RA2 A;  1DHJ A;  3INV A;  4G8Z X;  3QLZ A;  1RX6 A;  5DXV A;  2BLB A;  3N0H A;  4EIL A;  2GD9 A;  2W3V A;  1RA1 A;  4NX7 A;  2BLA A;  3NZD A;  3ZPG A;  3HJ3 A;  4I1N A;  2OIP A;  3FRA X;  1DR3 A;  1M79 A;  2ITH A;  1BZF A;  4QLG A;  4RGC A;  3K47 A;  3SA2 A;  3FRD X;  3VCO A;  1U70 A;  3NZB X;  1KLK A;  3TD8 A;  4KEB A;  1DRB A;  4DPH A;  2O7P A;  4FGH A;  4KFJ A;  3FRE X;  3SQY X;  2CD2 A;  3FY9 X;  7DFR A;  4P3Q A;  3R33 A;  4QLF A;  2W9S A;  3FQC A;  1CZ3 A;  2KGK A;  3CD2 A;  1RA9 A;  3TQB A;  3FQV A;  4ELH A;  2W3M A;  3SRW X;  3DAT A;  3EIG A;  3QLY A;  3FY8 X;  5EAJ A;  2JYB A;  4HOG A;  4DPD A;  2FZI A;  4HOF A;  3SRS X;  1DRF A;  2W9T A;  3KY8 A;  2H2Q A;  3QGT A;  3L3R A;  1DYI A;  1RA3 A;  3JWF A;  4HA9 A;  4H96 A;  3IRM A;  3UM8 A;  3IX9 A;  2HQP A;  1RG7 A;  1J3J A;  1RX1 A;  4XT7 A;  3UM5 A;  1RC4 A;  4M6J A;  3DAU A;  3KJS A;  1DAJ A;  1RX3 A;  4PDJ A;  1BOZ A;  5E8Q A;  4FHB A;  1J3I A;  3M09 A;  4ELF A;  1RA8 A;  1RE7 A;  4KNE A;  4PSS A;  4OSG A;  1E26 A;  1QZF A;  3F91 A;  2D0K A;  1ZDR A;  4TU5 X;  5U27 A;  4KM0 A;  1TDR A;  1PD9 A;  3NXX A;  5JA3 A;  3F0V X;  3F0B X;  2B3Z A;  3JW3 A;  1JOL A;  2W9G A;  3NXT A;  1LUD A;  2ANO A;  3SH2 A;  3NZA X;  1IA3 A;  2CIG A;  1RD7 A;  3DRC A;  4QJC A;  5CC9 A;  3GHV A;  4PST A;  5HT5 A;  3EEL A;  4P66 A;  4DFR A;  3FS6 A;  2XW7 A;  3JWC A;  4IXG X;  4EJ1 A;  5HUI A;  3NZC X;  3EEK A;  4P68 A;  1DYH A;  4H95 A;  3QYO A;  4XT6 A;  2BLC A;  1DG7 A;  3KGY A;  5HF0 X;  3EEJ A;  3IA5 A;  3QL3 A;  5DFR A;  5HSU A;  2W3A A;  1RB3 A;  3RO9 A;  2DRC A;  4LAE X;  4ECK A;  3FYV X; 
#chains in the Genus database with same CATH topology
 3EEM A;  3DFR A;  3OCH A;  4KD7 A;  3OAF A;  3FRB X;  3GI2 A;  1U72 A;  4M6K A;  4KJK A;  5HI6 A;  3SR5 X;  4KAK A;  4ELG A;  3QLR A;  2AZN A;  1PD8 A;  3TQA A;  4NX6 A;  4OR7 A;  4P3R A;  2BL9 A;  3JWK A;  3NTZ A;  1DDR A;  3FQO A;  4G3M A;  4LAH X;  4QHV A;  5HPB A;  5ECC A;  3NRR A;  5U26 A;  2HM9 A;  1U71 A;  2W3W A;  4X5I A;  1DR7 A;  3K45 A;  2ZZA A;  5HT4 A;  1DHI A;  3QG2 A;  4ELB A;  4M7U A;  3JWM A;  4H97 A;  4Q67 A;  3E0B A;  4M7V A;  3SRU X;  3RG9 A;  1RB2 A;  2HXV A;  3TQ9 A;  4HA7 A;  3HBB A;  2D5N A;  3NXR A;  1M78 A;  1S3V A;  1RF7 A;  1RX5 A;  4KLX A;  1M7A A;  4QJZ D;  3UM6 A;  1MVS A;  1LY4 A;  4XT5 A;  4EIG A;  3SRR X;  1S3Y A;  4XT4 A;  3D80 A;  3TQ8 A;  1DLR A;  5CCC A;  4XT8 A;  4DP3 A;  4LEK X;  4KJL A;  3FL8 A;  4FGG A;  4KL9 A;  3GYF A;  4GH8 A;  1AO8 A;  4Q0E A;  5HVE A;  3IRN A;  3F0Q X;  4X5G A;  3IA4 A;  5HVB A;  3IRO A;  2OBC A;  3K2H A;  3DGA A;  3SAI A;  3KFY A;  1AI9 A;  3F8Z A;  3CLB A;  4KJJ A;  1DLS A;  1JUV A;  4I13 A;  3ROA A;  3QFX A;  1DHF A;  3I8A X;  4Q0D A;  1DF7 A;  4KBN A;  6DFR A;  5HQY A;  3Q1H A;  3F0X X;  4KM2 A;  3QYL A;  3FYW X;  1MVT A;  2INQ A;  2DHF A;  1DRH A;  1DR6 A;  1IA1 A;  4M2X A;  1RX8 A;  3ZPC A;  4PTJ A;  3EX8 A;  1RX9 A;  2C2S A;  1DR2 A;  1IA4 A;  3NXV A;  2W3B A;  3FL9 A;  3JTW A;  3DL6 A;  3S9U A;  1DDS A;  4PTH A;  4XE6 X;  4EIZ A;  4KY8 A;  4H98 A;  1DRA A;  4CD2 A;  1KMV A;  1S3W A;  1DR1 A;  2QK8 A;  3I3R A;  3QLW A;  1AOE A;  1DRE A;  1DR5 A;  3F0U X;  3CSE A;  1DG5 A;  3JVX A;  1OHJ A;  1DIS A;  1HFP A;  1KMS A;  3GHW A;  3NZ9 X;  2W9H A;  3JSU A;  3QL0 A;  1DIU A;  3F8Y A;  3NXY A;  5HSR A;  1PDB A;  3S7A A;  3QLX A;  3SGY A;  5HQZ A;  3NXO A;  2ANQ A;  3SA1 A;  4X5F A;  4HOE A;  4G95 A;  4KYA A;  2C2T A;  3CL9 A;  2P4G A;  1RX7 A;  1LY3 A;  3M08 A;  3K74 A;  4LAG X;  4M6L A;  4IXE D;  3DL5 A;  4KY4 A;  1JOM A;  1D1G A;  8DFR A;  4PSY A;  4XRB A;  5ECX A;  5HF2 X;  1VJ3 A;  1RH3 A;  1DR4 A;  4QLE A;  1CD2 A;  4DDR A;  4X5H A;  1VDR A;  4ELE A;  2LF1 A;  3FQZ A;  1RX4 A;  1HFQ A;  1J3K A;  3JW5 A;  3LG4 A;  1HFR A;  3F0S X;  4X5J A;  3S3V A;  3DG8 A;  2L28 A;  4XEC X;  3FRF X;  3FQ0 A;  1DYR A;  3SRQ X;  1S3U A;  1OHK A;  1YHO A;  1SEJ A;  3D84 X;  5JG0 X;  2FZH A;  1RX2 A;  1IA2 A;  1DG8 A;  3KJR A;  4QI9 A;  3NU0 A;  3FQF A;  2G6V A;  1DYJ A;  5FDA A;  3QLS A;  4IXF X;  4Q6A A;  3GHC A;  3NZ6 X;  2FZJ A;  1RA2 A;  1DHJ A;  3INV A;  4G8Z X;  3QLZ A;  1RX6 A;  5DXV A;  2BLB A;  3N0H A;  4EIL A;  2GD9 A;  2W3V A;  1RA1 A;  4NX7 A;  2BLA A;  3NZD A;  3ZPG A;  3HJ3 A;  4I1N A;  2OIP A;  3FRA X;  1DR3 A;  1M79 A;  2ITH A;  1BZF A;  4QLG A;  4RGC A;  3K47 A;  3SA2 A;  3FRD X;  3VCO A;  1U70 A;  3NZB X;  1KLK A;  3TD8 A;  4KEB A;  1DRB A;  4DPH A;  2O7P A;  4FGH A;  4KFJ A;  3FRE X;  3SQY X;  2CD2 A;  3FY9 X;  7DFR A;  4P3Q A;  3R33 A;  4QLF A;  2W9S A;  3FQC A;  1CZ3 A;  2KGK A;  3CD2 A;  1RA9 A;  3TQB A;  3FQV A;  4ELH A;  2W3M A;  3SRW X;  3DAT A;  3EIG A;  3QLY A;  3FY8 X;  5EAJ A;  2JYB A;  4HOG A;  4DPD A;  2FZI A;  4HOF A;  3SRS X;  1DRF A;  2W9T A;  3KY8 A;  2H2Q A;  3QGT A;  3L3R A;  1DYI A;  1RA3 A;  3JWF A;  4HA9 A;  4H96 A;  3IRM A;  3UM8 A;  3IX9 A;  2HQP A;  1RG7 A;  1J3J A;  1RX1 A;  4XT7 A;  3UM5 A;  1RC4 A;  4M6J A;  3DAU A;  3KJS A;  1DAJ A;  1RX3 A;  4PDJ A;  1BOZ A;  5E8Q A;  4FHB A;  1J3I A;  3M09 A;  4ELF A;  1RA8 A;  1RE7 A;  4KNE A;  4PSS A;  4OSG A;  1E26 A;  1QZF A;  3F91 A;  2D0K A;  1ZDR A;  4TU5 X;  5U27 A;  4KM0 A;  1TDR A;  1PD9 A;  3NXX A;  5JA3 A;  3F0V X;  3F0B X;  2B3Z A;  3JW3 A;  1JOL A;  2W9G A;  3NXT A;  1LUD A;  2ANO A;  3SH2 A;  3NZA X;  1IA3 A;  2CIG A;  1RD7 A;  3DRC A;  4QJC A;  5CC9 A;  3GHV A;  4PST A;  5HT5 A;  3EEL A;  4P66 A;  4DFR A;  3FS6 A;  2XW7 A;  3JWC A;  4IXG X;  4EJ1 A;  5HUI A;  3NZC X;  3EEK A;  4P68 A;  1DYH A;  4H95 A;  3QYO A;  4XT6 A;  2BLC A;  1DG7 A;  3KGY A;  5HF0 X;  3EEJ A;  3IA5 A;  3QL3 A;  5DFR A;  5HSU A;  2W3A A;  1RB3 A;  3RO9 A;  2DRC A;  4LAE X;  4ECK A;  3FYV X; 
#chains in the Genus database with same CATH homology
 3EEM A;  3DFR A;  3OCH A;  4KD7 A;  3OAF A;  3FRB X;  3GI2 A;  1U72 A;  4M6K A;  4KJK A;  5HI6 A;  3SR5 X;  4KAK A;  4ELG A;  3QLR A;  2AZN A;  1PD8 A;  3TQA A;  4NX6 A;  4OR7 A;  4P3R A;  2BL9 A;  3JWK A;  3NTZ A;  1DDR A;  3FQO A;  4G3M A;  4LAH X;  4QHV A;  5HPB A;  5ECC A;  3NRR A;  5U26 A;  2HM9 A;  1U71 A;  2W3W A;  4X5I A;  1DR7 A;  3K45 A;  2ZZA A;  5HT4 A;  1DHI A;  3QG2 A;  4ELB A;  4M7U A;  3JWM A;  4H97 A;  4Q67 A;  3E0B A;  4M7V A;  3SRU X;  3RG9 A;  1RB2 A;  2HXV A;  3TQ9 A;  4HA7 A;  3HBB A;  2D5N A;  3NXR A;  1M78 A;  1S3V A;  1RF7 A;  1RX5 A;  4KLX A;  1M7A A;  4QJZ D;  3UM6 A;  1MVS A;  1LY4 A;  4XT5 A;  4EIG A;  3SRR X;  1S3Y A;  4XT4 A;  3D80 A;  3TQ8 A;  1DLR A;  5CCC A;  4XT8 A;  4DP3 A;  4LEK X;  4KJL A;  3FL8 A;  4FGG A;  4KL9 A;  3GYF A;  4GH8 A;  1AO8 A;  4Q0E A;  5HVE A;  3IRN A;  3F0Q X;  4X5G A;  3IA4 A;  5HVB A;  3IRO A;  2OBC A;  3K2H A;  3DGA A;  3SAI A;  3KFY A;  1AI9 A;  3F8Z A;  3CLB A;  4KJJ A;  1DLS A;  1JUV A;  4I13 A;  3ROA A;  3QFX A;  1DHF A;  3I8A X;  4Q0D A;  1DF7 A;  4KBN A;  6DFR A;  5HQY A;  3Q1H A;  3F0X X;  4KM2 A;  3QYL A;  3FYW X;  1MVT A;  2INQ A;  2DHF A;  1DRH A;  1DR6 A;  1IA1 A;  4M2X A;  1RX8 A;  3ZPC A;  4PTJ A;  3EX8 A;  1RX9 A;  2C2S A;  1DR2 A;  1IA4 A;  3NXV A;  2W3B A;  3FL9 A;  3JTW A;  3DL6 A;  3S9U A;  1DDS A;  4PTH A;  4XE6 X;  4EIZ A;  4KY8 A;  4H98 A;  1DRA A;  4CD2 A;  1KMV A;  1S3W A;  1DR1 A;  2QK8 A;  3I3R A;  3QLW A;  1AOE A;  1DRE A;  1DR5 A;  3F0U X;  3CSE A;  1DG5 A;  3JVX A;  1OHJ A;  1DIS A;  1HFP A;  1KMS A;  3GHW A;  3NZ9 X;  2W9H A;  3JSU A;  3QL0 A;  1DIU A;  3F8Y A;  3NXY A;  5HSR A;  1PDB A;  3S7A A;  3QLX A;  3SGY A;  5HQZ A;  3NXO A;  2ANQ A;  3SA1 A;  4X5F A;  4HOE A;  4G95 A;  4KYA A;  2C2T A;  3CL9 A;  2P4G A;  1RX7 A;  1LY3 A;  3M08 A;  3K74 A;  4LAG X;  4M6L A;  4IXE D;  3DL5 A;  4KY4 A;  1JOM A;  1D1G A;  8DFR A;  4PSY A;  4XRB A;  5ECX A;  5HF2 X;  1VJ3 A;  1RH3 A;  1DR4 A;  4QLE A;  1CD2 A;  4DDR A;  4X5H A;  1VDR A;  4ELE A;  2LF1 A;  3FQZ A;  1RX4 A;  1HFQ A;  1J3K A;  3JW5 A;  3LG4 A;  1HFR A;  3F0S X;  4X5J A;  3S3V A;  3DG8 A;  2L28 A;  4XEC X;  3FRF X;  3FQ0 A;  1DYR A;  3SRQ X;  1S3U A;  1OHK A;  1YHO A;  1SEJ A;  3D84 X;  5JG0 X;  2FZH A;  1RX2 A;  1IA2 A;  1DG8 A;  3KJR A;  4QI9 A;  3NU0 A;  3FQF A;  2G6V A;  1DYJ A;  5FDA A;  3QLS A;  4IXF X;  4Q6A A;  3GHC A;  3NZ6 X;  2FZJ A;  1RA2 A;  1DHJ A;  3INV A;  4G8Z X;  3QLZ A;  1RX6 A;  5DXV A;  2BLB A;  3N0H A;  4EIL A;  2GD9 A;  2W3V A;  1RA1 A;  4NX7 A;  2BLA A;  3NZD A;  3ZPG A;  3HJ3 A;  4I1N A;  2OIP A;  3FRA X;  1DR3 A;  1M79 A;  2ITH A;  1BZF A;  4QLG A;  4RGC A;  3K47 A;  3SA2 A;  3FRD X;  3VCO A;  1U70 A;  3NZB X;  1KLK A;  3TD8 A;  4KEB A;  1DRB A;  4DPH A;  2O7P A;  4FGH A;  4KFJ A;  3FRE X;  3SQY X;  2CD2 A;  3FY9 X;  7DFR A;  4P3Q A;  3R33 A;  4QLF A;  2W9S A;  3FQC A;  1CZ3 A;  2KGK A;  3CD2 A;  1RA9 A;  3TQB A;  3FQV A;  4ELH A;  2W3M A;  3SRW X;  3DAT A;  3EIG A;  3QLY A;  3FY8 X;  5EAJ A;  2JYB A;  4HOG A;  4DPD A;  2FZI A;  4HOF A;  3SRS X;  1DRF A;  2W9T A;  3KY8 A;  2H2Q A;  3QGT A;  3L3R A;  1DYI A;  1RA3 A;  3JWF A;  4HA9 A;  4H96 A;  3IRM A;  3UM8 A;  3IX9 A;  2HQP A;  1RG7 A;  1J3J A;  1RX1 A;  4XT7 A;  3UM5 A;  1RC4 A;  4M6J A;  3DAU A;  3KJS A;  1DAJ A;  1RX3 A;  4PDJ A;  1BOZ A;  5E8Q A;  4FHB A;  1J3I A;  3M09 A;  4ELF A;  1RA8 A;  1RE7 A;  4KNE A;  4PSS A;  4OSG A;  1E26 A;  1QZF A;  3F91 A;  2D0K A;  1ZDR A;  4TU5 X;  5U27 A;  4KM0 A;  1TDR A;  1PD9 A;  3NXX A;  5JA3 A;  3F0V X;  3F0B X;  2B3Z A;  3JW3 A;  1JOL A;  2W9G A;  3NXT A;  1LUD A;  2ANO A;  3SH2 A;  3NZA X;  1IA3 A;  2CIG A;  1RD7 A;  3DRC A;  4QJC A;  5CC9 A;  3GHV A;  4PST A;  5HT5 A;  3EEL A;  4P66 A;  4DFR A;  3FS6 A;  2XW7 A;  3JWC A;  4IXG X;  4EJ1 A;  5HUI A;  3NZC X;  3EEK A;  4P68 A;  1DYH A;  4H95 A;  3QYO A;  4XT6 A;  2BLC A;  1DG7 A;  3KGY A;  5HF0 X;  3EEJ A;  3IA5 A;  3QL3 A;  5DFR A;  5HSU A;  2W3A A;  1RB3 A;  3RO9 A;  2DRC A;  4LAE X;  4ECK A;  3FYV X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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