4KBNA

Human dihydrofolate reductase complexed with nadph and 5-{3-[3-(3,5-pyrimidine)]-phenyl-prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4diamine
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 53
structure length 186
sequence length 186
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-04-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4kbnA00
1DHIA 1AO8A 3UM8A 5HUIA 2BLCA 3GI2A 1DRAA 2QK8A 1RX7A 3D80A 3FL8A 4M6JA 5DXVA 3NZ6X 3NXTA 1DR4A 3NZBX 5FDAA 5HT5A 4XECX 4M6KA 1J3KA 1PD8A 3JWKA 4HA7A 4P68A 1DF7A 3TD8A 4HOGA 4Q0EA 3K45A 1DHFA 3FQVA 3GHWA 3JWMA 3SGYA 3SRUX 3K47A 4EIZA 1J3IA 2W9SA 3FS6A 1DRHA 4KY4A 1BOZA 2W3BA 4KJLA 4M2XA 4Q6AA 3ZPCA 5U26A 1RX6A 4XT5A 3EX8A 3TQ9A 3KY8A 3NXXA 3QL0A 2DRCA 2INQA 2W9HA 3FY9X 3OCHA 2OBCA 5HF2X 1DIUA 3SR5X 3HBBA 3SRQX 2DHFA 2FZHA 4QLEA 4KD7A 4IXED 3RO9A 1RX1A 2ITHA 3F0UX 1DREA 3NXRA 3R33A 2JYBA 5HPBA 2C2SA 4H98A 4IXFX 3E0BA 2GD9A 3JW5A 2OIPA 5HQZA 4QLFA 1S3WA 3FL9A 5DFRA 3IA5A 3DFRA 3FQCA 4KAKA 4KLXA 1DG8A 3GHCA 1MVSA 1M79A 1QZFA 2FZIA 3F0SX 3JWFA 4PSTA 3FQOA 1LY3A 4XRBA 3NZ9X 2LF1A 4XT4A 2B3ZA 4LAHX 3ROAA 5ECCA 5U27A 4H97A 3FRBX 3QGTA 3N0HA 1IA3A 3F8ZA 1U72A 4HOFA 3JVXA 4X5FA 3M08A 1MVTA 1RF7A 4FGGA 3DATA 4M6LA 3DG8A 4KFJA 1RC4A 3NRRA 3QYLA 3KJRA 1RX9A 3SRSX 3QLXA 3F0QX 1DG5A 3JWCA 1LY4A 3CD2A 1KMSA 3EIGA 5E8QA 1RE7A 4LEKX 4ELGA 3Q1HA 3SRRX 3K2HA 1DYJA 3NXYA 1VDRA 4H95A 5JA3A 1HFPA 3FREX 4PSYA 3SRWX 1DR5A 3UM6A 4P66A 1KLKA 3TQBA 4KY8A 3NXVA 3FQ0A 4G8ZX 1RX4A 1RD7A 3QLWA 5CCCA 1AOEA 4LAEX 3JW3A 1CZ3A 2BLBA 3FQFA 1DLSA 4QHVA 3IX9A 3SAIA 1S3VA 2ZZAA 1RH3A 3DL5A 1PD9A 3SH2A 4KYAA 3DGAA 1CD2A 8DFRA 4DP3A 4ELBA 4PDJA 3QLZA 4DPDA 1RG7A 1HFRA 2HM9A 4H96A 3FRFX 2W3AA 4KL9A 4QLGA 3CLBA 4OSGA 4X5GA 1OHJA 2L28A 3SQYX 3F91A 3LG4A 2D0KA 4DPHA 3EEKA 4KM0A 1U71A 4M7VA 1KMVA 1RA1A 4EJ1A 2D5NA 1DAJA 1JUVA 3FYWX 2W9TA 4HOEA 7DFRA 4QI9A 1DDRA 1DHJA 4OR7A 1DR6A 1S3UA 3IROA 5HSRA 2W9GA 3QLSA 1YHOA 3SA1A 3EEJA 1M7AA 4Q0DA 4DFRA 3F0XX 3DRCA 1RA8A 1DR3A 4EILA 5HSUA 4HA9A 3JTWA 3INVA 5HT4A 3HJ3A 1RB2A 4X5IA 4X5JA 3CL9A 1RX8A 1BZFA 4EIGA 1IA4A 1DYHA 4P3QA 1E26A 1HFQA 1DRFA 3KJSA 4QJZD 4KBNA 4ECKA 2HXVA 3NTZA 4PTJA 3FYVX 4IXGX 5HVBA 2BLAA 1RA2A 4XT8A 4DDRA 1IA2A 1RX5A 2W3WA 4PSSA 3FRAX 3DL6A 3RG9A 3KFYA 3I3RA 1RX3A 3FRDX 1DR1A 3F8YA 4LAGX 4GH8A 3FY8X 1SEJA 3TQ8A 2XW7A 1M78A 2CD2A 4KJJA 3EEMA 4ELFA 2ANOA 3GYFA 4I1NA 5HVEA 2G6VA 3F0BX 4XT6A 1DISA 3QL3A 4KNEA 3S9UA 4FHBA 3TQAA 3L3RA 1DYIA 3NXOA 3OAFA 4PTHA 1TDRA 1DG7A 5ECXA 5JG0X 4XT7A 5HI6A 2H2QA 3KGYA 5CC9A 3IA4A 1ZDRA 3K74A 1U70A 4FGHA 3D84X 3ZPGA 3NZAX 2W3MA 4M7UA 4KEBA 5EAJA 3IRNA 2HQPA 1JOLA 1RX2A 4TU5X 1DRBA 1DR2A 2KGKA 5HF0X 3NU0A 2FZJA 1IA1A 1JOMA 2ANQA 2C2TA 4Q67A 1DDSA 4ELEA 4KM2A 3S3VA 3QLRA 3QYOA 1D1GA 4CD2A 3EELA 3VCOA 2P4GA 1LUDA 3DAUA 3GHVA 2AZNA 4RGCA 4X5HA 1RA3A 3UM5A 1DR7A 4G95A 3I8AX 1RA9A 3NZDA 4I13A 3QFXA 5HQYA 4ELHA 1DYRA 1RB3A 3JSUA 4QJCA 1OHKA 3F0VX 1PDBA 6DFRA 3IRMA 2O7PA 3FQZA 4KJKA 3NZCX 1VJ3A 2CIGA 1S3YA 3SA2A 3QG2A 2W3VA 3QLYA 4NX6A 4P3RA 1AI9A 3CSEA 4G3MA 2BL9A 4NX7A 1J3JA 3M09A 1DLRA 3S7AA 4XE6X
chains in the Genus database with same CATH superfamily
1DHIA 1AO8A 3UM8A 5HUIA 2BLCA 3GI2A 1DRAA 2QK8A 1RX7A 3D80A 3FL8A 4M6JA 5DXVA 3NZ6X 3NXTA 1DR4A 3NZBX 5FDAA 5HT5A 4XECX 4M6KA 1J3KA 1PD8A 3JWKA 4HA7A 4P68A 1DF7A 3TD8A 4HOGA 4Q0EA 3K45A 1DHFA 3FQVA 3GHWA 3JWMA 3SGYA 3SRUX 3K47A 4EIZA 1J3IA 2W9SA 3FS6A 1DRHA 4KY4A 1BOZA 2W3BA 4KJLA 4M2XA 4Q6AA 3ZPCA 5U26A 1RX6A 4XT5A 3EX8A 3TQ9A 3KY8A 3NXXA 3QL0A 2DRCA 2INQA 2W9HA 3FY9X 3OCHA 2OBCA 5HF2X 1DIUA 3SR5X 3HBBA 3SRQX 2DHFA 2FZHA 4QLEA 4KD7A 4IXED 3RO9A 1RX1A 2ITHA 3F0UX 1DREA 3NXRA 3R33A 2JYBA 5HPBA 2C2SA 4H98A 4IXFX 3E0BA 2GD9A 3JW5A 2OIPA 5HQZA 4QLFA 1S3WA 3FL9A 5DFRA 3IA5A 3DFRA 3FQCA 4KAKA 4KLXA 1DG8A 3GHCA 1MVSA 1M79A 1QZFA 2FZIA 3F0SX 3JWFA 4PSTA 3FQOA 1LY3A 4XRBA 3NZ9X 2LF1A 4XT4A 2B3ZA 4LAHX 3ROAA 5ECCA 5U27A 4H97A 3FRBX 3QGTA 3N0HA 1IA3A 3F8ZA 1U72A 4HOFA 3JVXA 4X5FA 3M08A 1MVTA 1RF7A 4FGGA 3DATA 4M6LA 3DG8A 4KFJA 1RC4A 3NRRA 3QYLA 3KJRA 1RX9A 3SRSX 3QLXA 3F0QX 1DG5A 3JWCA 1LY4A 3CD2A 1KMSA 3EIGA 5E8QA 1RE7A 4LEKX 4ELGA 3Q1HA 3SRRX 3K2HA 1DYJA 3NXYA 1VDRA 4H95A 5JA3A 1HFPA 3FREX 4PSYA 3SRWX 1DR5A 3UM6A 4P66A 1KLKA 3TQBA 4KY8A 3NXVA 3FQ0A 4G8ZX 1RX4A 1RD7A 3QLWA 5CCCA 1AOEA 4LAEX 3JW3A 1CZ3A 2BLBA 3FQFA 1DLSA 4QHVA 3IX9A 3SAIA 1S3VA 2ZZAA 1RH3A 3DL5A 1PD9A 3SH2A 4KYAA 3DGAA 1CD2A 8DFRA 4DP3A 4ELBA 4PDJA 3QLZA 4DPDA 1RG7A 1HFRA 2HM9A 4H96A 3FRFX 2W3AA 4KL9A 4QLGA 3CLBA 4OSGA 4X5GA 1OHJA 2L28A 3SQYX 3F91A 3LG4A 2D0KA 4DPHA 3EEKA 4KM0A 1U71A 4M7VA 1KMVA 1RA1A 4EJ1A 2D5NA 1DAJA 1JUVA 3FYWX 2W9TA 4HOEA 7DFRA 4QI9A 1DDRA 1DHJA 4OR7A 1DR6A 1S3UA 3IROA 5HSRA 2W9GA 3QLSA 1YHOA 3SA1A 3EEJA 1M7AA 4Q0DA 4DFRA 3F0XX 3DRCA 1RA8A 1DR3A 4EILA 5HSUA 4HA9A 3JTWA 3INVA 5HT4A 3HJ3A 1RB2A 4X5IA 4X5JA 3CL9A 1RX8A 1BZFA 4EIGA 1IA4A 1DYHA 4P3QA 1E26A 1HFQA 1DRFA 3KJSA 4QJZD 4KBNA 4ECKA 2HXVA 3NTZA 4PTJA 3FYVX 4IXGX 5HVBA 2BLAA 1RA2A 4XT8A 4DDRA 1IA2A 1RX5A 2W3WA 4PSSA 3FRAX 3DL6A 3RG9A 3KFYA 3I3RA 1RX3A 3FRDX 1DR1A 3F8YA 4LAGX 4GH8A 3FY8X 1SEJA 3TQ8A 2XW7A 1M78A 2CD2A 4KJJA 3EEMA 4ELFA 2ANOA 3GYFA 4I1NA 5HVEA 2G6VA 3F0BX 4XT6A 1DISA 3QL3A 4KNEA 3S9UA 4FHBA 3TQAA 3L3RA 1DYIA 3NXOA 3OAFA 4PTHA 1TDRA 1DG7A 5ECXA 5JG0X 4XT7A 5HI6A 2H2QA 3KGYA 5CC9A 3IA4A 1ZDRA 3K74A 1U70A 4FGHA 3D84X 3ZPGA 3NZAX 2W3MA 4M7UA 4KEBA 5EAJA 3IRNA 2HQPA 1JOLA 1RX2A 4TU5X 1DRBA 1DR2A 2KGKA 5HF0X 3NU0A 2FZJA 1IA1A 1JOMA 2ANQA 2C2TA 4Q67A 1DDSA 4ELEA 4KM2A 3S3VA 3QLRA 3QYOA 1D1GA 4CD2A 3EELA 3VCOA 2P4GA 1LUDA 3DAUA 3GHVA 2AZNA 4RGCA 4X5HA 1RA3A 3UM5A 1DR7A 4G95A 3I8AX 1RA9A 3NZDA 4I13A 3QFXA 5HQYA 4ELHA 1DYRA 1RB3A 3JSUA 4QJCA 1OHKA 3F0VX 1PDBA 6DFRA 3IRMA 2O7PA 3FQZA 4KJKA 3NZCX 1VJ3A 2CIGA 1S3YA 3SA2A 3QG2A 2W3VA 3QLYA 4NX6A 4P3RA 1AI9A 3CSEA 4G3MA 2BL9A 4NX7A 1J3JA 3M09A 1DLRA 3S7AA 4XE6X
chains in the Genus database with same CATH topology
1DHIA 1AO8A 3UM8A 5HUIA 2BLCA 3GI2A 1DRAA 2QK8A 1RX7A 3D80A 3FL8A 4M6JA 5DXVA 3NZ6X 3NXTA 1DR4A 3NZBX 5FDAA 5HT5A 4XECX 4M6KA 1J3KA 1PD8A 3JWKA 4HA7A 4P68A 1DF7A 3TD8A 4HOGA 4Q0EA 3K45A 1DHFA 3FQVA 3GHWA 3JWMA 3SGYA 3SRUX 3K47A 4EIZA 1J3IA 2W9SA 3FS6A 1DRHA 4KY4A 1BOZA 2W3BA 4KJLA 4M2XA 4Q6AA 3ZPCA 5U26A 1RX6A 4XT5A 3EX8A 3TQ9A 3KY8A 3NXXA 3QL0A 2DRCA 2INQA 2W9HA 3FY9X 3OCHA 2OBCA 5HF2X 1DIUA 3SR5X 3HBBA 3SRQX 2DHFA 2FZHA 4QLEA 4KD7A 4IXED 3RO9A 1RX1A 2ITHA 3F0UX 1DREA 3NXRA 3R33A 2JYBA 5HPBA 2C2SA 4H98A 4IXFX 3E0BA 2GD9A 3JW5A 2OIPA 5HQZA 4QLFA 1S3WA 3FL9A 5DFRA 3IA5A 3DFRA 3FQCA 4KAKA 4KLXA 1DG8A 3GHCA 1MVSA 1M79A 1QZFA 2FZIA 3F0SX 3JWFA 4PSTA 3FQOA 1LY3A 4XRBA 3NZ9X 2LF1A 4XT4A 2B3ZA 4LAHX 3ROAA 5ECCA 5U27A 4H97A 3FRBX 3QGTA 3N0HA 1IA3A 3F8ZA 1U72A 4HOFA 3JVXA 4X5FA 3M08A 1MVTA 1RF7A 4FGGA 3DATA 4M6LA 3DG8A 4KFJA 1RC4A 3NRRA 3QYLA 3KJRA 1RX9A 3SRSX 3QLXA 3F0QX 1DG5A 3JWCA 1LY4A 3CD2A 1KMSA 3EIGA 5E8QA 1RE7A 4LEKX 4ELGA 3Q1HA 3SRRX 3K2HA 1DYJA 3NXYA 1VDRA 4H95A 5JA3A 1HFPA 3FREX 4PSYA 3SRWX 1DR5A 3UM6A 4P66A 1KLKA 3TQBA 4KY8A 3NXVA 3FQ0A 4G8ZX 1RX4A 1RD7A 3QLWA 5CCCA 1AOEA 4LAEX 3JW3A 1CZ3A 2BLBA 3FQFA 1DLSA 4QHVA 3IX9A 3SAIA 1S3VA 2ZZAA 1RH3A 3DL5A 1PD9A 3SH2A 4KYAA 3DGAA 1CD2A 8DFRA 4DP3A 4ELBA 4PDJA 3QLZA 4DPDA 1RG7A 1HFRA 2HM9A 4H96A 3FRFX 2W3AA 4KL9A 4QLGA 3CLBA 4OSGA 4X5GA 1OHJA 2L28A 3SQYX 3F91A 3LG4A 2D0KA 4DPHA 3EEKA 4KM0A 1U71A 4M7VA 1KMVA 1RA1A 4EJ1A 2D5NA 1DAJA 1JUVA 3FYWX 2W9TA 4HOEA 7DFRA 4QI9A 1DDRA 1DHJA 4OR7A 1DR6A 1S3UA 3IROA 5HSRA 2W9GA 3QLSA 1YHOA 3SA1A 3EEJA 1M7AA 4Q0DA 4DFRA 3F0XX 3DRCA 1RA8A 1DR3A 4EILA 5HSUA 4HA9A 3JTWA 3INVA 5HT4A 3HJ3A 1RB2A 4X5IA 4X5JA 3CL9A 1RX8A 1BZFA 4EIGA 1IA4A 1DYHA 4P3QA 1E26A 1HFQA 1DRFA 3KJSA 4QJZD 4KBNA 4ECKA 2HXVA 3NTZA 4PTJA 3FYVX 4IXGX 5HVBA 2BLAA 1RA2A 4XT8A 4DDRA 1IA2A 1RX5A 2W3WA 4PSSA 3FRAX 3DL6A 3RG9A 3KFYA 3I3RA 1RX3A 3FRDX 1DR1A 3F8YA 4LAGX 4GH8A 3FY8X 1SEJA 3TQ8A 2XW7A 1M78A 2CD2A 4KJJA 3EEMA 4ELFA 2ANOA 3GYFA 4I1NA 5HVEA 2G6VA 3F0BX 4XT6A 1DISA 3QL3A 4KNEA 3S9UA 4FHBA 3TQAA 3L3RA 1DYIA 3NXOA 3OAFA 4PTHA 1TDRA 1DG7A 5ECXA 5JG0X 4XT7A 5HI6A 2H2QA 3KGYA 5CC9A 3IA4A 1ZDRA 3K74A 1U70A 4FGHA 3D84X 3ZPGA 3NZAX 2W3MA 4M7UA 4KEBA 5EAJA 3IRNA 2HQPA 1JOLA 1RX2A 4TU5X 1DRBA 1DR2A 2KGKA 5HF0X 3NU0A 2FZJA 1IA1A 1JOMA 2ANQA 2C2TA 4Q67A 1DDSA 4ELEA 4KM2A 3S3VA 3QLRA 3QYOA 1D1GA 4CD2A 3EELA 3VCOA 2P4GA 1LUDA 3DAUA 3GHVA 2AZNA 4RGCA 4X5HA 1RA3A 3UM5A 1DR7A 4G95A 3I8AX 1RA9A 3NZDA 4I13A 3QFXA 5HQYA 4ELHA 1DYRA 1RB3A 3JSUA 4QJCA 1OHKA 3F0VX 1PDBA 6DFRA 3IRMA 2O7PA 3FQZA 4KJKA 3NZCX 1VJ3A 2CIGA 1S3YA 3SA2A 3QG2A 2W3VA 3QLYA 4NX6A 4P3RA 1AI9A 3CSEA 4G3MA 2BL9A 4NX7A 1J3JA 3M09A 1DLRA 3S7AA 4XE6X
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DHI A;  1AO8 A;  3UM8 A;  5HUI A;  2BLC A;  3GI2 A;  1DRA A;  2QK8 A;  1RX7 A;  3D80 A;  3FL8 A;  4M6J A;  5DXV A;  3NZ6 X;  3NXT A;  1DR4 A;  3NZB X;  5FDA A;  5HT5 A;  4XEC X;  4M6K A;  1J3K A;  1PD8 A;  3JWK A;  4HA7 A;  4P68 A;  1DF7 A;  3TD8 A;  4HOG A;  4Q0E A;  3K45 A;  1DHF A;  3FQV A;  3GHW A;  3JWM A;  3SGY A;  3SRU X;  3K47 A;  4EIZ A;  1J3I A;  2W9S A;  3FS6 A;  1DRH A;  4KY4 A;  1BOZ A;  2W3B A;  4KJL A;  4M2X A;  4Q6A A;  3ZPC A;  5U26 A;  1RX6 A;  4XT5 A;  3EX8 A;  3TQ9 A;  3KY8 A;  3NXX A;  3QL0 A;  2DRC A;  2INQ A;  2W9H A;  3FY9 X;  3OCH A;  2OBC A;  5HF2 X;  1DIU A;  3SR5 X;  3HBB A;  3SRQ X;  2DHF A;  2FZH A;  4QLE A;  4KD7 A;  4IXE D;  3RO9 A;  1RX1 A;  2ITH A;  3F0U X;  1DRE A;  3NXR A;  3R33 A;  2JYB A;  5HPB A;  2C2S A;  4H98 A;  4IXF X;  3E0B A;  2GD9 A;  3JW5 A;  2OIP A;  5HQZ A;  4QLF A;  1S3W A;  3FL9 A;  5DFR A;  3IA5 A;  3DFR A;  3FQC A;  4KAK A;  4KLX A;  1DG8 A;  3GHC A;  1MVS A;  1M79 A;  1QZF A;  2FZI A;  3F0S X;  3JWF A;  4PST A;  3FQO A;  1LY3 A;  4XRB A;  3NZ9 X;  2LF1 A;  4XT4 A;  2B3Z A;  4LAH X;  3ROA A;  5ECC A;  5U27 A;  4H97 A;  3FRB X;  3QGT A;  3N0H A;  1IA3 A;  3F8Z A;  1U72 A;  4HOF A;  3JVX A;  4X5F A;  3M08 A;  1MVT A;  1RF7 A;  4FGG A;  3DAT A;  4M6L A;  3DG8 A;  4KFJ A;  1RC4 A;  3NRR A;  3QYL A;  3KJR A;  1RX9 A;  3SRS X;  3QLX A;  3F0Q X;  1DG5 A;  3JWC A;  1LY4 A;  3CD2 A;  1KMS A;  3EIG A;  5E8Q A;  1RE7 A;  4LEK X;  4ELG A;  3Q1H A;  3SRR X;  3K2H A;  1DYJ A;  3NXY A;  1VDR A;  4H95 A;  5JA3 A;  1HFP A;  3FRE X;  4PSY A;  3SRW X;  1DR5 A;  3UM6 A;  4P66 A;  1KLK A;  3TQB A;  4KY8 A;  3NXV A;  3FQ0 A;  4G8Z X;  1RX4 A;  1RD7 A;  3QLW A;  5CCC A;  1AOE A;  4LAE X;  3JW3 A;  1CZ3 A;  2BLB A;  3FQF A;  1DLS A;  4QHV A;  3IX9 A;  3SAI A;  1S3V A;  2ZZA A;  1RH3 A;  3DL5 A;  1PD9 A;  3SH2 A;  4KYA A;  3DGA A;  1CD2 A;  8DFR A;  4DP3 A;  4ELB A;  4PDJ A;  3QLZ A;  4DPD A;  1RG7 A;  1HFR A;  2HM9 A;  4H96 A;  3FRF X;  2W3A A;  4KL9 A;  4QLG A;  3CLB A;  4OSG A;  4X5G A;  1OHJ A;  2L28 A;  3SQY X;  3F91 A;  3LG4 A;  2D0K A;  4DPH A;  3EEK A;  4KM0 A;  1U71 A;  4M7V A;  1KMV A;  1RA1 A;  4EJ1 A;  2D5N A;  1DAJ A;  1JUV A;  3FYW X;  2W9T A;  4HOE A;  7DFR A;  4QI9 A;  1DDR A;  1DHJ A;  4OR7 A;  1DR6 A;  1S3U A;  3IRO A;  5HSR A;  2W9G A;  3QLS A;  1YHO A;  3SA1 A;  3EEJ A;  1M7A A;  4Q0D A;  4DFR A;  3F0X X;  3DRC A;  1RA8 A;  1DR3 A;  4EIL A;  5HSU A;  4HA9 A;  3JTW A;  3INV A;  5HT4 A;  3HJ3 A;  1RB2 A;  4X5I A;  4X5J A;  3CL9 A;  1RX8 A;  1BZF A;  4EIG A;  1IA4 A;  1DYH A;  4P3Q A;  1E26 A;  1HFQ A;  1DRF A;  3KJS A;  4QJZ D;  4KBN A;  4ECK A;  2HXV A;  3NTZ A;  4PTJ A;  3FYV X;  4IXG X;  5HVB A;  2BLA A;  1RA2 A;  4XT8 A;  4DDR A;  1IA2 A;  1RX5 A;  2W3W A;  4PSS A;  3FRA X;  3DL6 A;  3RG9 A;  3KFY A;  3I3R A;  1RX3 A;  3FRD X;  1DR1 A;  3F8Y A;  4LAG X;  4GH8 A;  3FY8 X;  1SEJ A;  3TQ8 A;  2XW7 A;  1M78 A;  2CD2 A;  4KJJ A;  3EEM A;  4ELF A;  2ANO A;  3GYF A;  4I1N A;  5HVE A;  2G6V A;  3F0B X;  4XT6 A;  1DIS A;  3QL3 A;  4KNE A;  3S9U A;  4FHB A;  3TQA A;  3L3R A;  1DYI A;  3NXO A;  3OAF A;  4PTH A;  1TDR A;  1DG7 A;  5ECX A;  5JG0 X;  4XT7 A;  5HI6 A;  2H2Q A;  3KGY A;  5CC9 A;  3IA4 A;  1ZDR A;  3K74 A;  1U70 A;  4FGH A;  3D84 X;  3ZPG A;  3NZA X;  2W3M A;  4M7U A;  4KEB A;  5EAJ A;  3IRN A;  2HQP A;  1JOL A;  1RX2 A;  4TU5 X;  1DRB A;  1DR2 A;  2KGK A;  5HF0 X;  3NU0 A;  2FZJ A;  1IA1 A;  1JOM A;  2ANQ A;  2C2T A;  4Q67 A;  1DDS A;  4ELE A;  4KM2 A;  3S3V A;  3QLR A;  3QYO A;  1D1G A;  4CD2 A;  3EEL A;  3VCO A;  2P4G A;  1LUD A;  3DAU A;  3GHV A;  2AZN A;  4RGC A;  4X5H A;  1RA3 A;  3UM5 A;  1DR7 A;  4G95 A;  3I8A X;  1RA9 A;  3NZD A;  4I13 A;  3QFX A;  5HQY A;  4ELH A;  1DYR A;  1RB3 A;  3JSU A;  4QJC A;  1OHK A;  3F0V X;  1PDB A;  6DFR A;  3IRM A;  2O7P A;  3FQZ A;  4KJK A;  3NZC X;  1VJ3 A;  2CIG A;  1S3Y A;  3SA2 A;  3QG2 A;  2W3V A;  3QLY A;  4NX6 A;  4P3R A;  1AI9 A;  3CSE A;  4G3M A;  2BL9 A;  4NX7 A;  1J3J A;  3M09 A;  1DLR A;  3S7A A;  4XE6 X; 
#chains in the Genus database with same CATH topology
 1DHI A;  1AO8 A;  3UM8 A;  5HUI A;  2BLC A;  3GI2 A;  1DRA A;  2QK8 A;  1RX7 A;  3D80 A;  3FL8 A;  4M6J A;  5DXV A;  3NZ6 X;  3NXT A;  1DR4 A;  3NZB X;  5FDA A;  5HT5 A;  4XEC X;  4M6K A;  1J3K A;  1PD8 A;  3JWK A;  4HA7 A;  4P68 A;  1DF7 A;  3TD8 A;  4HOG A;  4Q0E A;  3K45 A;  1DHF A;  3FQV A;  3GHW A;  3JWM A;  3SGY A;  3SRU X;  3K47 A;  4EIZ A;  1J3I A;  2W9S A;  3FS6 A;  1DRH A;  4KY4 A;  1BOZ A;  2W3B A;  4KJL A;  4M2X A;  4Q6A A;  3ZPC A;  5U26 A;  1RX6 A;  4XT5 A;  3EX8 A;  3TQ9 A;  3KY8 A;  3NXX A;  3QL0 A;  2DRC A;  2INQ A;  2W9H A;  3FY9 X;  3OCH A;  2OBC A;  5HF2 X;  1DIU A;  3SR5 X;  3HBB A;  3SRQ X;  2DHF A;  2FZH A;  4QLE A;  4KD7 A;  4IXE D;  3RO9 A;  1RX1 A;  2ITH A;  3F0U X;  1DRE A;  3NXR A;  3R33 A;  2JYB A;  5HPB A;  2C2S A;  4H98 A;  4IXF X;  3E0B A;  2GD9 A;  3JW5 A;  2OIP A;  5HQZ A;  4QLF A;  1S3W A;  3FL9 A;  5DFR A;  3IA5 A;  3DFR A;  3FQC A;  4KAK A;  4KLX A;  1DG8 A;  3GHC A;  1MVS A;  1M79 A;  1QZF A;  2FZI A;  3F0S X;  3JWF A;  4PST A;  3FQO A;  1LY3 A;  4XRB A;  3NZ9 X;  2LF1 A;  4XT4 A;  2B3Z A;  4LAH X;  3ROA A;  5ECC A;  5U27 A;  4H97 A;  3FRB X;  3QGT A;  3N0H A;  1IA3 A;  3F8Z A;  1U72 A;  4HOF A;  3JVX A;  4X5F A;  3M08 A;  1MVT A;  1RF7 A;  4FGG A;  3DAT A;  4M6L A;  3DG8 A;  4KFJ A;  1RC4 A;  3NRR A;  3QYL A;  3KJR A;  1RX9 A;  3SRS X;  3QLX A;  3F0Q X;  1DG5 A;  3JWC A;  1LY4 A;  3CD2 A;  1KMS A;  3EIG A;  5E8Q A;  1RE7 A;  4LEK X;  4ELG A;  3Q1H A;  3SRR X;  3K2H A;  1DYJ A;  3NXY A;  1VDR A;  4H95 A;  5JA3 A;  1HFP A;  3FRE X;  4PSY A;  3SRW X;  1DR5 A;  3UM6 A;  4P66 A;  1KLK A;  3TQB A;  4KY8 A;  3NXV A;  3FQ0 A;  4G8Z X;  1RX4 A;  1RD7 A;  3QLW A;  5CCC A;  1AOE A;  4LAE X;  3JW3 A;  1CZ3 A;  2BLB A;  3FQF A;  1DLS A;  4QHV A;  3IX9 A;  3SAI A;  1S3V A;  2ZZA A;  1RH3 A;  3DL5 A;  1PD9 A;  3SH2 A;  4KYA A;  3DGA A;  1CD2 A;  8DFR A;  4DP3 A;  4ELB A;  4PDJ A;  3QLZ A;  4DPD A;  1RG7 A;  1HFR A;  2HM9 A;  4H96 A;  3FRF X;  2W3A A;  4KL9 A;  4QLG A;  3CLB A;  4OSG A;  4X5G A;  1OHJ A;  2L28 A;  3SQY X;  3F91 A;  3LG4 A;  2D0K A;  4DPH A;  3EEK A;  4KM0 A;  1U71 A;  4M7V A;  1KMV A;  1RA1 A;  4EJ1 A;  2D5N A;  1DAJ A;  1JUV A;  3FYW X;  2W9T A;  4HOE A;  7DFR A;  4QI9 A;  1DDR A;  1DHJ A;  4OR7 A;  1DR6 A;  1S3U A;  3IRO A;  5HSR A;  2W9G A;  3QLS A;  1YHO A;  3SA1 A;  3EEJ A;  1M7A A;  4Q0D A;  4DFR A;  3F0X X;  3DRC A;  1RA8 A;  1DR3 A;  4EIL A;  5HSU A;  4HA9 A;  3JTW A;  3INV A;  5HT4 A;  3HJ3 A;  1RB2 A;  4X5I A;  4X5J A;  3CL9 A;  1RX8 A;  1BZF A;  4EIG A;  1IA4 A;  1DYH A;  4P3Q A;  1E26 A;  1HFQ A;  1DRF A;  3KJS A;  4QJZ D;  4KBN A;  4ECK A;  2HXV A;  3NTZ A;  4PTJ A;  3FYV X;  4IXG X;  5HVB A;  2BLA A;  1RA2 A;  4XT8 A;  4DDR A;  1IA2 A;  1RX5 A;  2W3W A;  4PSS A;  3FRA X;  3DL6 A;  3RG9 A;  3KFY A;  3I3R A;  1RX3 A;  3FRD X;  1DR1 A;  3F8Y A;  4LAG X;  4GH8 A;  3FY8 X;  1SEJ A;  3TQ8 A;  2XW7 A;  1M78 A;  2CD2 A;  4KJJ A;  3EEM A;  4ELF A;  2ANO A;  3GYF A;  4I1N A;  5HVE A;  2G6V A;  3F0B X;  4XT6 A;  1DIS A;  3QL3 A;  4KNE A;  3S9U A;  4FHB A;  3TQA A;  3L3R A;  1DYI A;  3NXO A;  3OAF A;  4PTH A;  1TDR A;  1DG7 A;  5ECX A;  5JG0 X;  4XT7 A;  5HI6 A;  2H2Q A;  3KGY A;  5CC9 A;  3IA4 A;  1ZDR A;  3K74 A;  1U70 A;  4FGH A;  3D84 X;  3ZPG A;  3NZA X;  2W3M A;  4M7U A;  4KEB A;  5EAJ A;  3IRN A;  2HQP A;  1JOL A;  1RX2 A;  4TU5 X;  1DRB A;  1DR2 A;  2KGK A;  5HF0 X;  3NU0 A;  2FZJ A;  1IA1 A;  1JOM A;  2ANQ A;  2C2T A;  4Q67 A;  1DDS A;  4ELE A;  4KM2 A;  3S3V A;  3QLR A;  3QYO A;  1D1G A;  4CD2 A;  3EEL A;  3VCO A;  2P4G A;  1LUD A;  3DAU A;  3GHV A;  2AZN A;  4RGC A;  4X5H A;  1RA3 A;  3UM5 A;  1DR7 A;  4G95 A;  3I8A X;  1RA9 A;  3NZD A;  4I13 A;  3QFX A;  5HQY A;  4ELH A;  1DYR A;  1RB3 A;  3JSU A;  4QJC A;  1OHK A;  3F0V X;  1PDB A;  6DFR A;  3IRM A;  2O7P A;  3FQZ A;  4KJK A;  3NZC X;  1VJ3 A;  2CIG A;  1S3Y A;  3SA2 A;  3QG2 A;  2W3V A;  3QLY A;  4NX6 A;  4P3R A;  1AI9 A;  3CSE A;  4G3M A;  2BL9 A;  4NX7 A;  1J3J A;  3M09 A;  1DLR A;  3S7A A;  4XE6 X; 
#chains in the Genus database with same CATH homology
 1DHI A;  1AO8 A;  3UM8 A;  5HUI A;  2BLC A;  3GI2 A;  1DRA A;  2QK8 A;  1RX7 A;  3D80 A;  3FL8 A;  4M6J A;  5DXV A;  3NZ6 X;  3NXT A;  1DR4 A;  3NZB X;  5FDA A;  5HT5 A;  4XEC X;  4M6K A;  1J3K A;  1PD8 A;  3JWK A;  4HA7 A;  4P68 A;  1DF7 A;  3TD8 A;  4HOG A;  4Q0E A;  3K45 A;  1DHF A;  3FQV A;  3GHW A;  3JWM A;  3SGY A;  3SRU X;  3K47 A;  4EIZ A;  1J3I A;  2W9S A;  3FS6 A;  1DRH A;  4KY4 A;  1BOZ A;  2W3B A;  4KJL A;  4M2X A;  4Q6A A;  3ZPC A;  5U26 A;  1RX6 A;  4XT5 A;  3EX8 A;  3TQ9 A;  3KY8 A;  3NXX A;  3QL0 A;  2DRC A;  2INQ A;  2W9H A;  3FY9 X;  3OCH A;  2OBC A;  5HF2 X;  1DIU A;  3SR5 X;  3HBB A;  3SRQ X;  2DHF A;  2FZH A;  4QLE A;  4KD7 A;  4IXE D;  3RO9 A;  1RX1 A;  2ITH A;  3F0U X;  1DRE A;  3NXR A;  3R33 A;  2JYB A;  5HPB A;  2C2S A;  4H98 A;  4IXF X;  3E0B A;  2GD9 A;  3JW5 A;  2OIP A;  5HQZ A;  4QLF A;  1S3W A;  3FL9 A;  5DFR A;  3IA5 A;  3DFR A;  3FQC A;  4KAK A;  4KLX A;  1DG8 A;  3GHC A;  1MVS A;  1M79 A;  1QZF A;  2FZI A;  3F0S X;  3JWF A;  4PST A;  3FQO A;  1LY3 A;  4XRB A;  3NZ9 X;  2LF1 A;  4XT4 A;  2B3Z A;  4LAH X;  3ROA A;  5ECC A;  5U27 A;  4H97 A;  3FRB X;  3QGT A;  3N0H A;  1IA3 A;  3F8Z A;  1U72 A;  4HOF A;  3JVX A;  4X5F A;  3M08 A;  1MVT A;  1RF7 A;  4FGG A;  3DAT A;  4M6L A;  3DG8 A;  4KFJ A;  1RC4 A;  3NRR A;  3QYL A;  3KJR A;  1RX9 A;  3SRS X;  3QLX A;  3F0Q X;  1DG5 A;  3JWC A;  1LY4 A;  3CD2 A;  1KMS A;  3EIG A;  5E8Q A;  1RE7 A;  4LEK X;  4ELG A;  3Q1H A;  3SRR X;  3K2H A;  1DYJ A;  3NXY A;  1VDR A;  4H95 A;  5JA3 A;  1HFP A;  3FRE X;  4PSY A;  3SRW X;  1DR5 A;  3UM6 A;  4P66 A;  1KLK A;  3TQB A;  4KY8 A;  3NXV A;  3FQ0 A;  4G8Z X;  1RX4 A;  1RD7 A;  3QLW A;  5CCC A;  1AOE A;  4LAE X;  3JW3 A;  1CZ3 A;  2BLB A;  3FQF A;  1DLS A;  4QHV A;  3IX9 A;  3SAI A;  1S3V A;  2ZZA A;  1RH3 A;  3DL5 A;  1PD9 A;  3SH2 A;  4KYA A;  3DGA A;  1CD2 A;  8DFR A;  4DP3 A;  4ELB A;  4PDJ A;  3QLZ A;  4DPD A;  1RG7 A;  1HFR A;  2HM9 A;  4H96 A;  3FRF X;  2W3A A;  4KL9 A;  4QLG A;  3CLB A;  4OSG A;  4X5G A;  1OHJ A;  2L28 A;  3SQY X;  3F91 A;  3LG4 A;  2D0K A;  4DPH A;  3EEK A;  4KM0 A;  1U71 A;  4M7V A;  1KMV A;  1RA1 A;  4EJ1 A;  2D5N A;  1DAJ A;  1JUV A;  3FYW X;  2W9T A;  4HOE A;  7DFR A;  4QI9 A;  1DDR A;  1DHJ A;  4OR7 A;  1DR6 A;  1S3U A;  3IRO A;  5HSR A;  2W9G A;  3QLS A;  1YHO A;  3SA1 A;  3EEJ A;  1M7A A;  4Q0D A;  4DFR A;  3F0X X;  3DRC A;  1RA8 A;  1DR3 A;  4EIL A;  5HSU A;  4HA9 A;  3JTW A;  3INV A;  5HT4 A;  3HJ3 A;  1RB2 A;  4X5I A;  4X5J A;  3CL9 A;  1RX8 A;  1BZF A;  4EIG A;  1IA4 A;  1DYH A;  4P3Q A;  1E26 A;  1HFQ A;  1DRF A;  3KJS A;  4QJZ D;  4KBN A;  4ECK A;  2HXV A;  3NTZ A;  4PTJ A;  3FYV X;  4IXG X;  5HVB A;  2BLA A;  1RA2 A;  4XT8 A;  4DDR A;  1IA2 A;  1RX5 A;  2W3W A;  4PSS A;  3FRA X;  3DL6 A;  3RG9 A;  3KFY A;  3I3R A;  1RX3 A;  3FRD X;  1DR1 A;  3F8Y A;  4LAG X;  4GH8 A;  3FY8 X;  1SEJ A;  3TQ8 A;  2XW7 A;  1M78 A;  2CD2 A;  4KJJ A;  3EEM A;  4ELF A;  2ANO A;  3GYF A;  4I1N A;  5HVE A;  2G6V A;  3F0B X;  4XT6 A;  1DIS A;  3QL3 A;  4KNE A;  3S9U A;  4FHB A;  3TQA A;  3L3R A;  1DYI A;  3NXO A;  3OAF A;  4PTH A;  1TDR A;  1DG7 A;  5ECX A;  5JG0 X;  4XT7 A;  5HI6 A;  2H2Q A;  3KGY A;  5CC9 A;  3IA4 A;  1ZDR A;  3K74 A;  1U70 A;  4FGH A;  3D84 X;  3ZPG A;  3NZA X;  2W3M A;  4M7U A;  4KEB A;  5EAJ A;  3IRN A;  2HQP A;  1JOL A;  1RX2 A;  4TU5 X;  1DRB A;  1DR2 A;  2KGK A;  5HF0 X;  3NU0 A;  2FZJ A;  1IA1 A;  1JOM A;  2ANQ A;  2C2T A;  4Q67 A;  1DDS A;  4ELE A;  4KM2 A;  3S3V A;  3QLR A;  3QYO A;  1D1G A;  4CD2 A;  3EEL A;  3VCO A;  2P4G A;  1LUD A;  3DAU A;  3GHV A;  2AZN A;  4RGC A;  4X5H A;  1RA3 A;  3UM5 A;  1DR7 A;  4G95 A;  3I8A X;  1RA9 A;  3NZD A;  4I13 A;  3QFX A;  5HQY A;  4ELH A;  1DYR A;  1RB3 A;  3JSU A;  4QJC A;  1OHK A;  3F0V X;  1PDB A;  6DFR A;  3IRM A;  2O7P A;  3FQZ A;  4KJK A;  3NZC X;  1VJ3 A;  2CIG A;  1S3Y A;  3SA2 A;  3QG2 A;  2W3V A;  3QLY A;  4NX6 A;  4P3R A;  1AI9 A;  3CSE A;  4G3M A;  2BL9 A;  4NX7 A;  1J3J A;  3M09 A;  1DLR A;  3S7A A;  4XE6 X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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