4KD7A

Human dihydrofolate reductase complexed with nadph and 5-{3-[3-methoxy-5(pyridine-4-yl)phenyl]prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4-diamine
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 51
structure length 186
sequence length 186
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4kd7A00
5HT4A 3QG2A 3OCHA 4KY8A 2GD9A 4LAHX 1DR2A 3JW5A 4X5FA 1DHFA 2W9HA 1RH3A 2INQA 4XE6X 1AI9A 3INVA 3DG8A 3FRAX 3QGTA 3RG9A 4PSYA 4IXGX 3QLZA 2ANQA 3DGAA 8DFRA 1DREA 2D5NA 2KGKA 4I13A 5HVBA 3R33A 3IA4A 3FQZA 4XT7A 1LUDA 5CCCA 5FDAA 4KJKA 3NRRA 4QJCA 3FL8A 4CD2A 1MVTA 1S3YA 4LAGX 4Q0DA 3SQYX 5DFRA 2DHFA 3DRCA 1DHIA 2W9TA 1DISA 4RGCA 3FRBX 1YHOA 1OHKA 3LG4A 3NTZA 4G8ZX 4OR7A 1U70A 3KGYA 5CC9A 1RA2A 3TQBA 2BLBA 2L28A 5U27A 3SR5X 3K47A 1RC4A 2BLAA 4XT6A 4EILA 1QZFA 1AOEA 3SH2A 1RX8A 2XW7A 3UM5A 1DG5A 1PD9A 3JWFA 3EEJA 3FYWX 1J3JA 4Q67A 4HOFA 3JW3A 2FZIA 3EELA 3TD8A 3F0QX 5JA3A 4PSTA 4ELGA 3L3RA 4PTJA 3K74A 3NXOA 2DRCA 4KM0A 1PDBA 3DL5A 2H2QA 3FQOA 3KY8A 4KAKA 3CSEA 4GH8A 4M6JA 3FYVX 4H96A 4EIGA 1RX9A 5HSUA 4ELFA 1KMSA 3S7AA 1RA9A 2FZJA 4HA9A 1RA1A 4QI9A 4EIZA 2OBCA 3CD2A 4TU5X 1DHJA 1DDSA 4ELBA 1RB2A 1CD2A 4IXFX 1DG7A 1DLRA 3GI2A 3KJRA 4DDRA 3SRQX 1VJ3A 4EJ1A 1DR6A 4KFJA 3S9UA 3KFYA 2W3BA 3NZDA 4QHVA 2QK8A 4NX6A 2HQPA 3ROAA 3QFXA 5HT5A 3KJSA 1RX4A 1RG7A 2CD2A 1DR5A 5HQZA 1HFPA 5HPBA 3QLXA 1IA4A 3SAIA 4H98A 1DYHA 3HJ3A 1JUVA 2W3MA 2W3AA 3F0SX 3K45A 1J3KA 1D1GA 4KBNA 3SA2A 2G6VA 2FZHA 2ZZAA 3FQFA 1CZ3A 3K2HA 3GYFA 3FREX 3DFRA 1RA8A 3EEKA 5HQYA 3SRSX 1VDRA 2W9SA 4KJLA 3IA5A 4OSGA 1DRFA 4Q6AA 3NZ6X 2BL9A 3QL0A 5DXVA 4KJJA 1DYIA 4QJZD 7DFRA 4KEBA 1S3VA 3FL9A 4P3RA 5HSRA 4PDJA 4DP3A 1DIUA 1M7AA 1LY4A 3GHWA 4HOEA 4KYAA 4FGGA 1M79A 3FRDX 4X5GA 1KLKA 5HF2X 2ANOA 2C2TA 4KD7A 3GHCA 3QLYA 3NXVA 1RA3A 4X5JA 3HBBA 3QLRA 3M08A 3NXTA 4M7VA 2W3WA 4DFRA 2W3VA 3JVXA 4QLFA 4I1NA 3E0BA 3EIGA 1RD7A 3EX8A 4M6LA 1KMVA 4ELEA 4XT4A 3FY8X 1SEJA 6DFRA 3QYLA 3NZBX 3SRWX 4XECX 1BZFA 3FQCA 3JWMA 3ZPCA 1HFQA 2C2SA 4M2XA 3F0BX 3F0UX 5JG0X 1S3UA 3SRRX 3F8YA 3EEMA 1IA1A 4KL9A 1DF7A 4ELHA 4LEKX 1RX5A 1DYJA 3UM6A 3Q1HA 3SRUX 3OAFA 4H95A 4ECKA 1RX1A 3DATA 1RX3A 2LF1A 4QLGA 1LY3A 3JWCA 3ZPGA 1IA2A 3JSUA 3QL3A 4DPHA 1DR1A 3QLWA 3DL6A 3F91A 4DPDA 3I3RA 4KY4A 4M6KA 3F0XX 3TQ8A 3QLSA 3TQ9A 3SA1A 1MVSA 2BLCA 3IRMA 3N0HA 3M09A 4HA7A 4P66A 2HXVA 1AO8A 1RE7A 1U72A 3NXYA 2HM9A 1DAJA 3IRNA 1BOZA 4FGHA 1DRAA 3CL9A 3IX9A 3NZ9X 4LAEX 4PSSA 1DG8A 3I8AX 1U71A 3NU0A 4Q0EA 5HI6A 1RB3A 3F0VX 4M7UA 4X5IA 2AZNA 3D84X 2OIPA 3GHVA 2ITHA 3CLBA 5E8QA 4QLEA 4PTHA 2O7PA 5EAJA 1DR4A 3FY9X 5HVEA 1OHJA 5HF0X 4XT5A 1E26A 4X5HA 3D80A 3FRFX 4HOGA 3JTWA 1JOMA 3F8ZA 1RF7A 1JOLA 2P4GA 1RX6A 3NZAX 5U26A 1DRBA 1TDRA 1DR7A 1M78A 2D0KA 1PD8A 5ECCA 3IROA 2JYBA 1DR3A 4KLXA 1DRHA 2B3ZA 4H97A 3FS6A 1J3IA 1DLSA 3VCOA 1ZDRA 5ECXA 1DDRA 4G3MA 3TQAA 1S3WA 4NX7A 4P3QA 4G95A 1DYRA 3NZCX 3NXRA 3S3VA 2CIGA 2W9GA 1RX2A 4KNEA 3NXXA 3UM8A 1IA3A 3FQ0A 3DAUA 4P68A 1HFRA 4KM2A 4XT8A 3SGYA 5HUIA 3QYOA 4IXED 3JWKA 3RO9A 3FQVA 4FHBA 1RX7A 4XRBA
chains in the Genus database with same CATH superfamily
5HT4A 3QG2A 3OCHA 4KY8A 2GD9A 4LAHX 1DR2A 3JW5A 4X5FA 1DHFA 2W9HA 1RH3A 2INQA 4XE6X 1AI9A 3INVA 3DG8A 3FRAX 3QGTA 3RG9A 4PSYA 4IXGX 3QLZA 2ANQA 3DGAA 8DFRA 1DREA 2D5NA 2KGKA 4I13A 5HVBA 3R33A 3IA4A 3FQZA 4XT7A 1LUDA 5CCCA 5FDAA 4KJKA 3NRRA 4QJCA 3FL8A 4CD2A 1MVTA 1S3YA 4LAGX 4Q0DA 3SQYX 5DFRA 2DHFA 3DRCA 1DHIA 2W9TA 1DISA 4RGCA 3FRBX 1YHOA 1OHKA 3LG4A 3NTZA 4G8ZX 4OR7A 1U70A 3KGYA 5CC9A 1RA2A 3TQBA 2BLBA 2L28A 5U27A 3SR5X 3K47A 1RC4A 2BLAA 4XT6A 4EILA 1QZFA 1AOEA 3SH2A 1RX8A 2XW7A 3UM5A 1DG5A 1PD9A 3JWFA 3EEJA 3FYWX 1J3JA 4Q67A 4HOFA 3JW3A 2FZIA 3EELA 3TD8A 3F0QX 5JA3A 4PSTA 4ELGA 3L3RA 4PTJA 3K74A 3NXOA 2DRCA 4KM0A 1PDBA 3DL5A 2H2QA 3FQOA 3KY8A 4KAKA 3CSEA 4GH8A 4M6JA 3FYVX 4H96A 4EIGA 1RX9A 5HSUA 4ELFA 1KMSA 3S7AA 1RA9A 2FZJA 4HA9A 1RA1A 4QI9A 4EIZA 2OBCA 3CD2A 4TU5X 1DHJA 1DDSA 4ELBA 1RB2A 1CD2A 4IXFX 1DG7A 1DLRA 3GI2A 3KJRA 4DDRA 3SRQX 1VJ3A 4EJ1A 1DR6A 4KFJA 3S9UA 3KFYA 2W3BA 3NZDA 4QHVA 2QK8A 4NX6A 2HQPA 3ROAA 3QFXA 5HT5A 3KJSA 1RX4A 1RG7A 2CD2A 1DR5A 5HQZA 1HFPA 5HPBA 3QLXA 1IA4A 3SAIA 4H98A 1DYHA 3HJ3A 1JUVA 2W3MA 2W3AA 3F0SX 3K45A 1J3KA 1D1GA 4KBNA 3SA2A 2G6VA 2FZHA 2ZZAA 3FQFA 1CZ3A 3K2HA 3GYFA 3FREX 3DFRA 1RA8A 3EEKA 5HQYA 3SRSX 1VDRA 2W9SA 4KJLA 3IA5A 4OSGA 1DRFA 4Q6AA 3NZ6X 2BL9A 3QL0A 5DXVA 4KJJA 1DYIA 4QJZD 7DFRA 4KEBA 1S3VA 3FL9A 4P3RA 5HSRA 4PDJA 4DP3A 1DIUA 1M7AA 1LY4A 3GHWA 4HOEA 4KYAA 4FGGA 1M79A 3FRDX 4X5GA 1KLKA 5HF2X 2ANOA 2C2TA 4KD7A 3GHCA 3QLYA 3NXVA 1RA3A 4X5JA 3HBBA 3QLRA 3M08A 3NXTA 4M7VA 2W3WA 4DFRA 2W3VA 3JVXA 4QLFA 4I1NA 3E0BA 3EIGA 1RD7A 3EX8A 4M6LA 1KMVA 4ELEA 4XT4A 3FY8X 1SEJA 6DFRA 3QYLA 3NZBX 3SRWX 4XECX 1BZFA 3FQCA 3JWMA 3ZPCA 1HFQA 2C2SA 4M2XA 3F0BX 3F0UX 5JG0X 1S3UA 3SRRX 3F8YA 3EEMA 1IA1A 4KL9A 1DF7A 4ELHA 4LEKX 1RX5A 1DYJA 3UM6A 3Q1HA 3SRUX 3OAFA 4H95A 4ECKA 1RX1A 3DATA 1RX3A 2LF1A 4QLGA 1LY3A 3JWCA 3ZPGA 1IA2A 3JSUA 3QL3A 4DPHA 1DR1A 3QLWA 3DL6A 3F91A 4DPDA 3I3RA 4KY4A 4M6KA 3F0XX 3TQ8A 3QLSA 3TQ9A 3SA1A 1MVSA 2BLCA 3IRMA 3N0HA 3M09A 4HA7A 4P66A 2HXVA 1AO8A 1RE7A 1U72A 3NXYA 2HM9A 1DAJA 3IRNA 1BOZA 4FGHA 1DRAA 3CL9A 3IX9A 3NZ9X 4LAEX 4PSSA 1DG8A 3I8AX 1U71A 3NU0A 4Q0EA 5HI6A 1RB3A 3F0VX 4M7UA 4X5IA 2AZNA 3D84X 2OIPA 3GHVA 2ITHA 3CLBA 5E8QA 4QLEA 4PTHA 2O7PA 5EAJA 1DR4A 3FY9X 5HVEA 1OHJA 5HF0X 4XT5A 1E26A 4X5HA 3D80A 3FRFX 4HOGA 3JTWA 1JOMA 3F8ZA 1RF7A 1JOLA 2P4GA 1RX6A 3NZAX 5U26A 1DRBA 1TDRA 1DR7A 1M78A 2D0KA 1PD8A 5ECCA 3IROA 2JYBA 1DR3A 4KLXA 1DRHA 2B3ZA 4H97A 3FS6A 1J3IA 1DLSA 3VCOA 1ZDRA 5ECXA 1DDRA 4G3MA 3TQAA 1S3WA 4NX7A 4P3QA 4G95A 1DYRA 3NZCX 3NXRA 3S3VA 2CIGA 2W9GA 1RX2A 4KNEA 3NXXA 3UM8A 1IA3A 3FQ0A 3DAUA 4P68A 1HFRA 4KM2A 4XT8A 3SGYA 5HUIA 3QYOA 4IXED 3JWKA 3RO9A 3FQVA 4FHBA 1RX7A 4XRBA
chains in the Genus database with same CATH topology
5HT4A 3QG2A 3OCHA 4KY8A 2GD9A 4LAHX 1DR2A 3JW5A 4X5FA 1DHFA 2W9HA 1RH3A 2INQA 4XE6X 1AI9A 3INVA 3DG8A 3FRAX 3QGTA 3RG9A 4PSYA 4IXGX 3QLZA 2ANQA 3DGAA 8DFRA 1DREA 2D5NA 2KGKA 4I13A 5HVBA 3R33A 3IA4A 3FQZA 4XT7A 1LUDA 5CCCA 5FDAA 4KJKA 3NRRA 4QJCA 3FL8A 4CD2A 1MVTA 1S3YA 4LAGX 4Q0DA 3SQYX 5DFRA 2DHFA 3DRCA 1DHIA 2W9TA 1DISA 4RGCA 3FRBX 1YHOA 1OHKA 3LG4A 3NTZA 4G8ZX 4OR7A 1U70A 3KGYA 5CC9A 1RA2A 3TQBA 2BLBA 2L28A 5U27A 3SR5X 3K47A 1RC4A 2BLAA 4XT6A 4EILA 1QZFA 1AOEA 3SH2A 1RX8A 2XW7A 3UM5A 1DG5A 1PD9A 3JWFA 3EEJA 3FYWX 1J3JA 4Q67A 4HOFA 3JW3A 2FZIA 3EELA 3TD8A 3F0QX 5JA3A 4PSTA 4ELGA 3L3RA 4PTJA 3K74A 3NXOA 2DRCA 4KM0A 1PDBA 3DL5A 2H2QA 3FQOA 3KY8A 4KAKA 3CSEA 4GH8A 4M6JA 3FYVX 4H96A 4EIGA 1RX9A 5HSUA 4ELFA 1KMSA 3S7AA 1RA9A 2FZJA 4HA9A 1RA1A 4QI9A 4EIZA 2OBCA 3CD2A 4TU5X 1DHJA 1DDSA 4ELBA 1RB2A 1CD2A 4IXFX 1DG7A 1DLRA 3GI2A 3KJRA 4DDRA 3SRQX 1VJ3A 4EJ1A 1DR6A 4KFJA 3S9UA 3KFYA 2W3BA 3NZDA 4QHVA 2QK8A 4NX6A 2HQPA 3ROAA 3QFXA 5HT5A 3KJSA 1RX4A 1RG7A 2CD2A 1DR5A 5HQZA 1HFPA 5HPBA 3QLXA 1IA4A 3SAIA 4H98A 1DYHA 3HJ3A 1JUVA 2W3MA 2W3AA 3F0SX 3K45A 1J3KA 1D1GA 4KBNA 3SA2A 2G6VA 2FZHA 2ZZAA 3FQFA 1CZ3A 3K2HA 3GYFA 3FREX 3DFRA 1RA8A 3EEKA 5HQYA 3SRSX 1VDRA 2W9SA 4KJLA 3IA5A 4OSGA 1DRFA 4Q6AA 3NZ6X 2BL9A 3QL0A 5DXVA 4KJJA 1DYIA 4QJZD 7DFRA 4KEBA 1S3VA 3FL9A 4P3RA 5HSRA 4PDJA 4DP3A 1DIUA 1M7AA 1LY4A 3GHWA 4HOEA 4KYAA 4FGGA 1M79A 3FRDX 4X5GA 1KLKA 5HF2X 2ANOA 2C2TA 4KD7A 3GHCA 3QLYA 3NXVA 1RA3A 4X5JA 3HBBA 3QLRA 3M08A 3NXTA 4M7VA 2W3WA 4DFRA 2W3VA 3JVXA 4QLFA 4I1NA 3E0BA 3EIGA 1RD7A 3EX8A 4M6LA 1KMVA 4ELEA 4XT4A 3FY8X 1SEJA 6DFRA 3QYLA 3NZBX 3SRWX 4XECX 1BZFA 3FQCA 3JWMA 3ZPCA 1HFQA 2C2SA 4M2XA 3F0BX 3F0UX 5JG0X 1S3UA 3SRRX 3F8YA 3EEMA 1IA1A 4KL9A 1DF7A 4ELHA 4LEKX 1RX5A 1DYJA 3UM6A 3Q1HA 3SRUX 3OAFA 4H95A 4ECKA 1RX1A 3DATA 1RX3A 2LF1A 4QLGA 1LY3A 3JWCA 3ZPGA 1IA2A 3JSUA 3QL3A 4DPHA 1DR1A 3QLWA 3DL6A 3F91A 4DPDA 3I3RA 4KY4A 4M6KA 3F0XX 3TQ8A 3QLSA 3TQ9A 3SA1A 1MVSA 2BLCA 3IRMA 3N0HA 3M09A 4HA7A 4P66A 2HXVA 1AO8A 1RE7A 1U72A 3NXYA 2HM9A 1DAJA 3IRNA 1BOZA 4FGHA 1DRAA 3CL9A 3IX9A 3NZ9X 4LAEX 4PSSA 1DG8A 3I8AX 1U71A 3NU0A 4Q0EA 5HI6A 1RB3A 3F0VX 4M7UA 4X5IA 2AZNA 3D84X 2OIPA 3GHVA 2ITHA 3CLBA 5E8QA 4QLEA 4PTHA 2O7PA 5EAJA 1DR4A 3FY9X 5HVEA 1OHJA 5HF0X 4XT5A 1E26A 4X5HA 3D80A 3FRFX 4HOGA 3JTWA 1JOMA 3F8ZA 1RF7A 1JOLA 2P4GA 1RX6A 3NZAX 5U26A 1DRBA 1TDRA 1DR7A 1M78A 2D0KA 1PD8A 5ECCA 3IROA 2JYBA 1DR3A 4KLXA 1DRHA 2B3ZA 4H97A 3FS6A 1J3IA 1DLSA 3VCOA 1ZDRA 5ECXA 1DDRA 4G3MA 3TQAA 1S3WA 4NX7A 4P3QA 4G95A 1DYRA 3NZCX 3NXRA 3S3VA 2CIGA 2W9GA 1RX2A 4KNEA 3NXXA 3UM8A 1IA3A 3FQ0A 3DAUA 4P68A 1HFRA 4KM2A 4XT8A 3SGYA 5HUIA 3QYOA 4IXED 3JWKA 3RO9A 3FQVA 4FHBA 1RX7A 4XRBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HT4 A;  3QG2 A;  3OCH A;  4KY8 A;  2GD9 A;  4LAH X;  1DR2 A;  3JW5 A;  4X5F A;  1DHF A;  2W9H A;  1RH3 A;  2INQ A;  4XE6 X;  1AI9 A;  3INV A;  3DG8 A;  3FRA X;  3QGT A;  3RG9 A;  4PSY A;  4IXG X;  3QLZ A;  2ANQ A;  3DGA A;  8DFR A;  1DRE A;  2D5N A;  2KGK A;  4I13 A;  5HVB A;  3R33 A;  3IA4 A;  3FQZ A;  4XT7 A;  1LUD A;  5CCC A;  5FDA A;  4KJK A;  3NRR A;  4QJC A;  3FL8 A;  4CD2 A;  1MVT A;  1S3Y A;  4LAG X;  4Q0D A;  3SQY X;  5DFR A;  2DHF A;  3DRC A;  1DHI A;  2W9T A;  1DIS A;  4RGC A;  3FRB X;  1YHO A;  1OHK A;  3LG4 A;  3NTZ A;  4G8Z X;  4OR7 A;  1U70 A;  3KGY A;  5CC9 A;  1RA2 A;  3TQB A;  2BLB A;  2L28 A;  5U27 A;  3SR5 X;  3K47 A;  1RC4 A;  2BLA A;  4XT6 A;  4EIL A;  1QZF A;  1AOE A;  3SH2 A;  1RX8 A;  2XW7 A;  3UM5 A;  1DG5 A;  1PD9 A;  3JWF A;  3EEJ A;  3FYW X;  1J3J A;  4Q67 A;  4HOF A;  3JW3 A;  2FZI A;  3EEL A;  3TD8 A;  3F0Q X;  5JA3 A;  4PST A;  4ELG A;  3L3R A;  4PTJ A;  3K74 A;  3NXO A;  2DRC A;  4KM0 A;  1PDB A;  3DL5 A;  2H2Q A;  3FQO A;  3KY8 A;  4KAK A;  3CSE A;  4GH8 A;  4M6J A;  3FYV X;  4H96 A;  4EIG A;  1RX9 A;  5HSU A;  4ELF A;  1KMS A;  3S7A A;  1RA9 A;  2FZJ A;  4HA9 A;  1RA1 A;  4QI9 A;  4EIZ A;  2OBC A;  3CD2 A;  4TU5 X;  1DHJ A;  1DDS A;  4ELB A;  1RB2 A;  1CD2 A;  4IXF X;  1DG7 A;  1DLR A;  3GI2 A;  3KJR A;  4DDR A;  3SRQ X;  1VJ3 A;  4EJ1 A;  1DR6 A;  4KFJ A;  3S9U A;  3KFY A;  2W3B A;  3NZD A;  4QHV A;  2QK8 A;  4NX6 A;  2HQP A;  3ROA A;  3QFX A;  5HT5 A;  3KJS A;  1RX4 A;  1RG7 A;  2CD2 A;  1DR5 A;  5HQZ A;  1HFP A;  5HPB A;  3QLX A;  1IA4 A;  3SAI A;  4H98 A;  1DYH A;  3HJ3 A;  1JUV A;  2W3M A;  2W3A A;  3F0S X;  3K45 A;  1J3K A;  1D1G A;  4KBN A;  3SA2 A;  2G6V A;  2FZH A;  2ZZA A;  3FQF A;  1CZ3 A;  3K2H A;  3GYF A;  3FRE X;  3DFR A;  1RA8 A;  3EEK A;  5HQY A;  3SRS X;  1VDR A;  2W9S A;  4KJL A;  3IA5 A;  4OSG A;  1DRF A;  4Q6A A;  3NZ6 X;  2BL9 A;  3QL0 A;  5DXV A;  4KJJ A;  1DYI A;  4QJZ D;  7DFR A;  4KEB A;  1S3V A;  3FL9 A;  4P3R A;  5HSR A;  4PDJ A;  4DP3 A;  1DIU A;  1M7A A;  1LY4 A;  3GHW A;  4HOE A;  4KYA A;  4FGG A;  1M79 A;  3FRD X;  4X5G A;  1KLK A;  5HF2 X;  2ANO A;  2C2T A;  4KD7 A;  3GHC A;  3QLY A;  3NXV A;  1RA3 A;  4X5J A;  3HBB A;  3QLR A;  3M08 A;  3NXT A;  4M7V A;  2W3W A;  4DFR A;  2W3V A;  3JVX A;  4QLF A;  4I1N A;  3E0B A;  3EIG A;  1RD7 A;  3EX8 A;  4M6L A;  1KMV A;  4ELE A;  4XT4 A;  3FY8 X;  1SEJ A;  6DFR A;  3QYL A;  3NZB X;  3SRW X;  4XEC X;  1BZF A;  3FQC A;  3JWM A;  3ZPC A;  1HFQ A;  2C2S A;  4M2X A;  3F0B X;  3F0U X;  5JG0 X;  1S3U A;  3SRR X;  3F8Y A;  3EEM A;  1IA1 A;  4KL9 A;  1DF7 A;  4ELH A;  4LEK X;  1RX5 A;  1DYJ A;  3UM6 A;  3Q1H A;  3SRU X;  3OAF A;  4H95 A;  4ECK A;  1RX1 A;  3DAT A;  1RX3 A;  2LF1 A;  4QLG A;  1LY3 A;  3JWC A;  3ZPG A;  1IA2 A;  3JSU A;  3QL3 A;  4DPH A;  1DR1 A;  3QLW A;  3DL6 A;  3F91 A;  4DPD A;  3I3R A;  4KY4 A;  4M6K A;  3F0X X;  3TQ8 A;  3QLS A;  3TQ9 A;  3SA1 A;  1MVS A;  2BLC A;  3IRM A;  3N0H A;  3M09 A;  4HA7 A;  4P66 A;  2HXV A;  1AO8 A;  1RE7 A;  1U72 A;  3NXY A;  2HM9 A;  1DAJ A;  3IRN A;  1BOZ A;  4FGH A;  1DRA A;  3CL9 A;  3IX9 A;  3NZ9 X;  4LAE X;  4PSS A;  1DG8 A;  3I8A X;  1U71 A;  3NU0 A;  4Q0E A;  5HI6 A;  1RB3 A;  3F0V X;  4M7U A;  4X5I A;  2AZN A;  3D84 X;  2OIP A;  3GHV A;  2ITH A;  3CLB A;  5E8Q A;  4QLE A;  4PTH A;  2O7P A;  5EAJ A;  1DR4 A;  3FY9 X;  5HVE A;  1OHJ A;  5HF0 X;  4XT5 A;  1E26 A;  4X5H A;  3D80 A;  3FRF X;  4HOG A;  3JTW A;  1JOM A;  3F8Z A;  1RF7 A;  1JOL A;  2P4G A;  1RX6 A;  3NZA X;  5U26 A;  1DRB A;  1TDR A;  1DR7 A;  1M78 A;  2D0K A;  1PD8 A;  5ECC A;  3IRO A;  2JYB A;  1DR3 A;  4KLX A;  1DRH A;  2B3Z A;  4H97 A;  3FS6 A;  1J3I A;  1DLS A;  3VCO A;  1ZDR A;  5ECX A;  1DDR A;  4G3M A;  3TQA A;  1S3W A;  4NX7 A;  4P3Q A;  4G95 A;  1DYR A;  3NZC X;  3NXR A;  3S3V A;  2CIG A;  2W9G A;  1RX2 A;  4KNE A;  3NXX A;  3UM8 A;  1IA3 A;  3FQ0 A;  3DAU A;  4P68 A;  1HFR A;  4KM2 A;  4XT8 A;  3SGY A;  5HUI A;  3QYO A;  4IXE D;  3JWK A;  3RO9 A;  3FQV A;  4FHB A;  1RX7 A;  4XRB A; 
#chains in the Genus database with same CATH topology
 5HT4 A;  3QG2 A;  3OCH A;  4KY8 A;  2GD9 A;  4LAH X;  1DR2 A;  3JW5 A;  4X5F A;  1DHF A;  2W9H A;  1RH3 A;  2INQ A;  4XE6 X;  1AI9 A;  3INV A;  3DG8 A;  3FRA X;  3QGT A;  3RG9 A;  4PSY A;  4IXG X;  3QLZ A;  2ANQ A;  3DGA A;  8DFR A;  1DRE A;  2D5N A;  2KGK A;  4I13 A;  5HVB A;  3R33 A;  3IA4 A;  3FQZ A;  4XT7 A;  1LUD A;  5CCC A;  5FDA A;  4KJK A;  3NRR A;  4QJC A;  3FL8 A;  4CD2 A;  1MVT A;  1S3Y A;  4LAG X;  4Q0D A;  3SQY X;  5DFR A;  2DHF A;  3DRC A;  1DHI A;  2W9T A;  1DIS A;  4RGC A;  3FRB X;  1YHO A;  1OHK A;  3LG4 A;  3NTZ A;  4G8Z X;  4OR7 A;  1U70 A;  3KGY A;  5CC9 A;  1RA2 A;  3TQB A;  2BLB A;  2L28 A;  5U27 A;  3SR5 X;  3K47 A;  1RC4 A;  2BLA A;  4XT6 A;  4EIL A;  1QZF A;  1AOE A;  3SH2 A;  1RX8 A;  2XW7 A;  3UM5 A;  1DG5 A;  1PD9 A;  3JWF A;  3EEJ A;  3FYW X;  1J3J A;  4Q67 A;  4HOF A;  3JW3 A;  2FZI A;  3EEL A;  3TD8 A;  3F0Q X;  5JA3 A;  4PST A;  4ELG A;  3L3R A;  4PTJ A;  3K74 A;  3NXO A;  2DRC A;  4KM0 A;  1PDB A;  3DL5 A;  2H2Q A;  3FQO A;  3KY8 A;  4KAK A;  3CSE A;  4GH8 A;  4M6J A;  3FYV X;  4H96 A;  4EIG A;  1RX9 A;  5HSU A;  4ELF A;  1KMS A;  3S7A A;  1RA9 A;  2FZJ A;  4HA9 A;  1RA1 A;  4QI9 A;  4EIZ A;  2OBC A;  3CD2 A;  4TU5 X;  1DHJ A;  1DDS A;  4ELB A;  1RB2 A;  1CD2 A;  4IXF X;  1DG7 A;  1DLR A;  3GI2 A;  3KJR A;  4DDR A;  3SRQ X;  1VJ3 A;  4EJ1 A;  1DR6 A;  4KFJ A;  3S9U A;  3KFY A;  2W3B A;  3NZD A;  4QHV A;  2QK8 A;  4NX6 A;  2HQP A;  3ROA A;  3QFX A;  5HT5 A;  3KJS A;  1RX4 A;  1RG7 A;  2CD2 A;  1DR5 A;  5HQZ A;  1HFP A;  5HPB A;  3QLX A;  1IA4 A;  3SAI A;  4H98 A;  1DYH A;  3HJ3 A;  1JUV A;  2W3M A;  2W3A A;  3F0S X;  3K45 A;  1J3K A;  1D1G A;  4KBN A;  3SA2 A;  2G6V A;  2FZH A;  2ZZA A;  3FQF A;  1CZ3 A;  3K2H A;  3GYF A;  3FRE X;  3DFR A;  1RA8 A;  3EEK A;  5HQY A;  3SRS X;  1VDR A;  2W9S A;  4KJL A;  3IA5 A;  4OSG A;  1DRF A;  4Q6A A;  3NZ6 X;  2BL9 A;  3QL0 A;  5DXV A;  4KJJ A;  1DYI A;  4QJZ D;  7DFR A;  4KEB A;  1S3V A;  3FL9 A;  4P3R A;  5HSR A;  4PDJ A;  4DP3 A;  1DIU A;  1M7A A;  1LY4 A;  3GHW A;  4HOE A;  4KYA A;  4FGG A;  1M79 A;  3FRD X;  4X5G A;  1KLK A;  5HF2 X;  2ANO A;  2C2T A;  4KD7 A;  3GHC A;  3QLY A;  3NXV A;  1RA3 A;  4X5J A;  3HBB A;  3QLR A;  3M08 A;  3NXT A;  4M7V A;  2W3W A;  4DFR A;  2W3V A;  3JVX A;  4QLF A;  4I1N A;  3E0B A;  3EIG A;  1RD7 A;  3EX8 A;  4M6L A;  1KMV A;  4ELE A;  4XT4 A;  3FY8 X;  1SEJ A;  6DFR A;  3QYL A;  3NZB X;  3SRW X;  4XEC X;  1BZF A;  3FQC A;  3JWM A;  3ZPC A;  1HFQ A;  2C2S A;  4M2X A;  3F0B X;  3F0U X;  5JG0 X;  1S3U A;  3SRR X;  3F8Y A;  3EEM A;  1IA1 A;  4KL9 A;  1DF7 A;  4ELH A;  4LEK X;  1RX5 A;  1DYJ A;  3UM6 A;  3Q1H A;  3SRU X;  3OAF A;  4H95 A;  4ECK A;  1RX1 A;  3DAT A;  1RX3 A;  2LF1 A;  4QLG A;  1LY3 A;  3JWC A;  3ZPG A;  1IA2 A;  3JSU A;  3QL3 A;  4DPH A;  1DR1 A;  3QLW A;  3DL6 A;  3F91 A;  4DPD A;  3I3R A;  4KY4 A;  4M6K A;  3F0X X;  3TQ8 A;  3QLS A;  3TQ9 A;  3SA1 A;  1MVS A;  2BLC A;  3IRM A;  3N0H A;  3M09 A;  4HA7 A;  4P66 A;  2HXV A;  1AO8 A;  1RE7 A;  1U72 A;  3NXY A;  2HM9 A;  1DAJ A;  3IRN A;  1BOZ A;  4FGH A;  1DRA A;  3CL9 A;  3IX9 A;  3NZ9 X;  4LAE X;  4PSS A;  1DG8 A;  3I8A X;  1U71 A;  3NU0 A;  4Q0E A;  5HI6 A;  1RB3 A;  3F0V X;  4M7U A;  4X5I A;  2AZN A;  3D84 X;  2OIP A;  3GHV A;  2ITH A;  3CLB A;  5E8Q A;  4QLE A;  4PTH A;  2O7P A;  5EAJ A;  1DR4 A;  3FY9 X;  5HVE A;  1OHJ A;  5HF0 X;  4XT5 A;  1E26 A;  4X5H A;  3D80 A;  3FRF X;  4HOG A;  3JTW A;  1JOM A;  3F8Z A;  1RF7 A;  1JOL A;  2P4G A;  1RX6 A;  3NZA X;  5U26 A;  1DRB A;  1TDR A;  1DR7 A;  1M78 A;  2D0K A;  1PD8 A;  5ECC A;  3IRO A;  2JYB A;  1DR3 A;  4KLX A;  1DRH A;  2B3Z A;  4H97 A;  3FS6 A;  1J3I A;  1DLS A;  3VCO A;  1ZDR A;  5ECX A;  1DDR A;  4G3M A;  3TQA A;  1S3W A;  4NX7 A;  4P3Q A;  4G95 A;  1DYR A;  3NZC X;  3NXR A;  3S3V A;  2CIG A;  2W9G A;  1RX2 A;  4KNE A;  3NXX A;  3UM8 A;  1IA3 A;  3FQ0 A;  3DAU A;  4P68 A;  1HFR A;  4KM2 A;  4XT8 A;  3SGY A;  5HUI A;  3QYO A;  4IXE D;  3JWK A;  3RO9 A;  3FQV A;  4FHB A;  1RX7 A;  4XRB A; 
#chains in the Genus database with same CATH homology
 5HT4 A;  3QG2 A;  3OCH A;  4KY8 A;  2GD9 A;  4LAH X;  1DR2 A;  3JW5 A;  4X5F A;  1DHF A;  2W9H A;  1RH3 A;  2INQ A;  4XE6 X;  1AI9 A;  3INV A;  3DG8 A;  3FRA X;  3QGT A;  3RG9 A;  4PSY A;  4IXG X;  3QLZ A;  2ANQ A;  3DGA A;  8DFR A;  1DRE A;  2D5N A;  2KGK A;  4I13 A;  5HVB A;  3R33 A;  3IA4 A;  3FQZ A;  4XT7 A;  1LUD A;  5CCC A;  5FDA A;  4KJK A;  3NRR A;  4QJC A;  3FL8 A;  4CD2 A;  1MVT A;  1S3Y A;  4LAG X;  4Q0D A;  3SQY X;  5DFR A;  2DHF A;  3DRC A;  1DHI A;  2W9T A;  1DIS A;  4RGC A;  3FRB X;  1YHO A;  1OHK A;  3LG4 A;  3NTZ A;  4G8Z X;  4OR7 A;  1U70 A;  3KGY A;  5CC9 A;  1RA2 A;  3TQB A;  2BLB A;  2L28 A;  5U27 A;  3SR5 X;  3K47 A;  1RC4 A;  2BLA A;  4XT6 A;  4EIL A;  1QZF A;  1AOE A;  3SH2 A;  1RX8 A;  2XW7 A;  3UM5 A;  1DG5 A;  1PD9 A;  3JWF A;  3EEJ A;  3FYW X;  1J3J A;  4Q67 A;  4HOF A;  3JW3 A;  2FZI A;  3EEL A;  3TD8 A;  3F0Q X;  5JA3 A;  4PST A;  4ELG A;  3L3R A;  4PTJ A;  3K74 A;  3NXO A;  2DRC A;  4KM0 A;  1PDB A;  3DL5 A;  2H2Q A;  3FQO A;  3KY8 A;  4KAK A;  3CSE A;  4GH8 A;  4M6J A;  3FYV X;  4H96 A;  4EIG A;  1RX9 A;  5HSU A;  4ELF A;  1KMS A;  3S7A A;  1RA9 A;  2FZJ A;  4HA9 A;  1RA1 A;  4QI9 A;  4EIZ A;  2OBC A;  3CD2 A;  4TU5 X;  1DHJ A;  1DDS A;  4ELB A;  1RB2 A;  1CD2 A;  4IXF X;  1DG7 A;  1DLR A;  3GI2 A;  3KJR A;  4DDR A;  3SRQ X;  1VJ3 A;  4EJ1 A;  1DR6 A;  4KFJ A;  3S9U A;  3KFY A;  2W3B A;  3NZD A;  4QHV A;  2QK8 A;  4NX6 A;  2HQP A;  3ROA A;  3QFX A;  5HT5 A;  3KJS A;  1RX4 A;  1RG7 A;  2CD2 A;  1DR5 A;  5HQZ A;  1HFP A;  5HPB A;  3QLX A;  1IA4 A;  3SAI A;  4H98 A;  1DYH A;  3HJ3 A;  1JUV A;  2W3M A;  2W3A A;  3F0S X;  3K45 A;  1J3K A;  1D1G A;  4KBN A;  3SA2 A;  2G6V A;  2FZH A;  2ZZA A;  3FQF A;  1CZ3 A;  3K2H A;  3GYF A;  3FRE X;  3DFR A;  1RA8 A;  3EEK A;  5HQY A;  3SRS X;  1VDR A;  2W9S A;  4KJL A;  3IA5 A;  4OSG A;  1DRF A;  4Q6A A;  3NZ6 X;  2BL9 A;  3QL0 A;  5DXV A;  4KJJ A;  1DYI A;  4QJZ D;  7DFR A;  4KEB A;  1S3V A;  3FL9 A;  4P3R A;  5HSR A;  4PDJ A;  4DP3 A;  1DIU A;  1M7A A;  1LY4 A;  3GHW A;  4HOE A;  4KYA A;  4FGG A;  1M79 A;  3FRD X;  4X5G A;  1KLK A;  5HF2 X;  2ANO A;  2C2T A;  4KD7 A;  3GHC A;  3QLY A;  3NXV A;  1RA3 A;  4X5J A;  3HBB A;  3QLR A;  3M08 A;  3NXT A;  4M7V A;  2W3W A;  4DFR A;  2W3V A;  3JVX A;  4QLF A;  4I1N A;  3E0B A;  3EIG A;  1RD7 A;  3EX8 A;  4M6L A;  1KMV A;  4ELE A;  4XT4 A;  3FY8 X;  1SEJ A;  6DFR A;  3QYL A;  3NZB X;  3SRW X;  4XEC X;  1BZF A;  3FQC A;  3JWM A;  3ZPC A;  1HFQ A;  2C2S A;  4M2X A;  3F0B X;  3F0U X;  5JG0 X;  1S3U A;  3SRR X;  3F8Y A;  3EEM A;  1IA1 A;  4KL9 A;  1DF7 A;  4ELH A;  4LEK X;  1RX5 A;  1DYJ A;  3UM6 A;  3Q1H A;  3SRU X;  3OAF A;  4H95 A;  4ECK A;  1RX1 A;  3DAT A;  1RX3 A;  2LF1 A;  4QLG A;  1LY3 A;  3JWC A;  3ZPG A;  1IA2 A;  3JSU A;  3QL3 A;  4DPH A;  1DR1 A;  3QLW A;  3DL6 A;  3F91 A;  4DPD A;  3I3R A;  4KY4 A;  4M6K A;  3F0X X;  3TQ8 A;  3QLS A;  3TQ9 A;  3SA1 A;  1MVS A;  2BLC A;  3IRM A;  3N0H A;  3M09 A;  4HA7 A;  4P66 A;  2HXV A;  1AO8 A;  1RE7 A;  1U72 A;  3NXY A;  2HM9 A;  1DAJ A;  3IRN A;  1BOZ A;  4FGH A;  1DRA A;  3CL9 A;  3IX9 A;  3NZ9 X;  4LAE X;  4PSS A;  1DG8 A;  3I8A X;  1U71 A;  3NU0 A;  4Q0E A;  5HI6 A;  1RB3 A;  3F0V X;  4M7U A;  4X5I A;  2AZN A;  3D84 X;  2OIP A;  3GHV A;  2ITH A;  3CLB A;  5E8Q A;  4QLE A;  4PTH A;  2O7P A;  5EAJ A;  1DR4 A;  3FY9 X;  5HVE A;  1OHJ A;  5HF0 X;  4XT5 A;  1E26 A;  4X5H A;  3D80 A;  3FRF X;  4HOG A;  3JTW A;  1JOM A;  3F8Z A;  1RF7 A;  1JOL A;  2P4G A;  1RX6 A;  3NZA X;  5U26 A;  1DRB A;  1TDR A;  1DR7 A;  1M78 A;  2D0K A;  1PD8 A;  5ECC A;  3IRO A;  2JYB A;  1DR3 A;  4KLX A;  1DRH A;  2B3Z A;  4H97 A;  3FS6 A;  1J3I A;  1DLS A;  3VCO A;  1ZDR A;  5ECX A;  1DDR A;  4G3M A;  3TQA A;  1S3W A;  4NX7 A;  4P3Q A;  4G95 A;  1DYR A;  3NZC X;  3NXR A;  3S3V A;  2CIG A;  2W9G A;  1RX2 A;  4KNE A;  3NXX A;  3UM8 A;  1IA3 A;  3FQ0 A;  3DAU A;  4P68 A;  1HFR A;  4KM2 A;  4XT8 A;  3SGY A;  5HUI A;  3QYO A;  4IXE D;  3JWK A;  3RO9 A;  3FQV A;  4FHB A;  1RX7 A;  4XRB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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