4LEKX

Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
157
structure length
157
Chain Sequence
TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Staphylococcus aureus
molecule keywords Dihydrofolate reductase
total genus 43
structure length 157
sequence length 157
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-06-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4lekX00
3TQ9A 1DLSA 1M7AA 2W3MA 4XT6A 1KLKA 4NX6A 3JWCA 4ELGA 3FRFX 3EX8A 6DFRA 2ANQA 2ZZAA 4ELHA 5JG0X 4DP3A 5CC9A 2W9GA 1DR2A 4QJZD 1DRBA 3F0VX 2D0KA 5EAJA 3NZ6X 3FQFA 1LY4A 3F0XX 4IXFX 3RG9A 2FZIA 4P68A 1AO8A 4QI9A 3KY8A 3NXVA 1RA3A 2BL9A 5HSUA 3HJ3A 3FS6A 1DR6A 3FRDX 3JW3A 3K74A 2C2TA 4Q0DA 1IA2A 4HA9A 2JYBA 1RA1A 1KMSA 3ZPGA 3IA4A 1RB2A 1PD8A 1DLRA 3QGTA 3K2HA 4QJCA 1U71A 4M6JA 1LY3A 1DYHA 1DF7A 1VDRA 4HOGA 3RO9A 4DFRA 4LAEX 3NZDA 2QK8A 2LF1A 3EELA 4EILA 4Q0EA 1RX4A 7DFRA 4KFJA 3FREX 3F0BX 1J3JA 1RA8A 1DREA 3NXYA 2W9TA 3JW5A 1YHOA 1PDBA 4P3RA 1LUDA 8DFRA 4M6LA 1U70A 1DYIA 1IA4A 3D80A 4IXED 3CD2A 3DFRA 4EIGA 3QLYA 4LAGX 3F0QX 1DAJA 2C2SA 2FZJA 3D84X 3NU0A 2L28A 4KJLA 4FHBA 5FDAA 2DHFA 3S3VA 3QYOA 4QLGA 4PTHA 3IROA 1DR4A 3JWFA 3TQ8A 4EIZA 3FQOA 1DRHA 4KJJA 3R33A 4OSGA 4QLFA 4TU5X 1DYRA 2B3ZA 1DR7A 4XT5A 1RC4A 4XT8A 3FRBX 2KGKA 3SQYX 1HFPA 5HUIA 3NZCX 3EEMA 3SR5X 5HT5A 1IA3A 1RX6A 2HM9A 3K45A 3SRQX 4X5JA 4KL9A 3FQ0A 3EEKA 3FQVA 4H95A 3L3RA 1CD2A 1RB3A 5HVEA 1D1GA 4G3MA 4XRBA 4H98A 4ELBA 4G8ZX 5HPBA 4KM0A 4PSTA 1DDRA 4Q67A 3JVXA 4PTJA 1HFQA 3NTZA 1S3WA 1AOEA 3DG8A 3FQZA 4X5HA 5HF0X 3FY9X 4XT7A 3FRAX 1RX3A 3F91A 3UM5A 4HA7A 3F8YA 1DRAA 3EIGA 5DFRA 4ECKA 4RGCA 2XW7A 2BLCA 3JWKA 3SRRX 3KFYA 3LG4A 4DPDA 3S9UA 1RA2A 3FYVX 1RX9A 4KYAA 1RE7A 4DPHA 3F8ZA 1DG5A 3QL0A 4CD2A 1QZFA 1DG8A 3EEJA 3QLWA 4M7VA 1MVTA 3NXOA 4PSYA 3FYWX 1RX1A 4KNEA 4LEKX 2FZHA 3DGAA 4IXGX 4XT4A 1RF7A 5E8QA 1DR3A 4X5IA 4KBNA 5ECXA 3GYFA 1J3KA 1IA1A 1SEJA 4M6KA 4XECX 3NXRA 3ROAA 2W3VA 3I8AX 3QLSA 1HFRA 3DRCA 5HF2X 3DAUA 3QLZA 2OBCA 4Q6AA 2W3BA 3SGYA 3CLBA 3NXXA 3KJSA 3M09A 2ITHA 3K47A 5HVBA 4P3QA 1S3YA 3IA5A 3NRRA 3TD8A 3QLRA 2W9HA 4NX7A 2AZNA 3NXTA 1RA9A 3GI2A 2G6VA 3NZBX 1DISA 3I3RA 4LAHX 1E26A 1RX2A 1RX5A 1JOMA 3DATA 5U26A 2ANOA 5DXVA 2H2QA 1OHKA 5ECCA 5U27A 4ELEA 4HOFA 1DR5A 2CIGA 3SH2A 3NZAX 3IX9A 2OIPA 1DRFA 1S3UA 1M78A 1OHJA 1KMVA 3CL9A 5HI6A 3ZPCA 1DHIA 4M7UA 3F0UX 3JSUA 1DG7A 3S7AA 3TQAA 2BLBA 5HQYA 2HQPA 3QYLA 1DDSA 3SA2A 4PSSA 4GH8A 1RH3A 1U72A 1DHJA 3UM6A 2INQA 3QG2A 3UM8A 2BLAA 3INVA 3VCOA 3GHWA 4FGHA 3TQBA 2O7PA 4XE6X 4QHVA 3CSEA 3FQCA 3JTWA 2D5NA 2HXVA 1JOLA 4HOEA 3OCHA 4KD7A 5HQZA 4QLEA 3DL6A 3SA1A 4KEBA 3IRMA 2P4GA 3QLXA 5HSRA 1DHFA 1AI9A 4KY8A 4H97A 3SRSX 1PD9A 4I13A 4OR7A 3F0SX 3FY8X 4KJKA 4KLXA 1JUVA 4I1NA 1DR1A 3DL5A 2GD9A 3KJRA 1VJ3A 1S3VA 3JWMA 4PDJA 1ZDRA 2W9SA 1J3IA 1RX7A 3E0BA 3SAIA 3IRNA 3OAFA 2W3WA 4M2XA 1DYJA 3QL3A 4P66A 3HBBA 2CD2A 3FL8A 4G95A 5HT4A 1BZFA 4H96A 3FL9A 3KGYA 3NZ9X 1TDRA 2DRCA 5CCCA 1DIUA 1BOZA 5JA3A 1CZ3A 3M08A 3GHVA 4FGGA 4KY4A 3QFXA 3SRUX 4EJ1A 4ELFA 3GHCA 3N0HA 4X5GA 3Q1HA 4KAKA 3SRWX 1M79A 4KM2A 1RD7A 4X5FA 1MVSA 1RG7A 1RX8A 2W3AA 4DDRA
chains in the Genus database with same CATH superfamily
3TQ9A 1DLSA 1M7AA 2W3MA 4XT6A 1KLKA 4NX6A 3JWCA 4ELGA 3FRFX 3EX8A 6DFRA 2ANQA 2ZZAA 4ELHA 5JG0X 4DP3A 5CC9A 2W9GA 1DR2A 4QJZD 1DRBA 3F0VX 2D0KA 5EAJA 3NZ6X 3FQFA 1LY4A 3F0XX 4IXFX 3RG9A 2FZIA 4P68A 1AO8A 4QI9A 3KY8A 3NXVA 1RA3A 2BL9A 5HSUA 3HJ3A 3FS6A 1DR6A 3FRDX 3JW3A 3K74A 2C2TA 4Q0DA 1IA2A 4HA9A 2JYBA 1RA1A 1KMSA 3ZPGA 3IA4A 1RB2A 1PD8A 1DLRA 3QGTA 3K2HA 4QJCA 1U71A 4M6JA 1LY3A 1DYHA 1DF7A 1VDRA 4HOGA 3RO9A 4DFRA 4LAEX 3NZDA 2QK8A 2LF1A 3EELA 4EILA 4Q0EA 1RX4A 7DFRA 4KFJA 3FREX 3F0BX 1J3JA 1RA8A 1DREA 3NXYA 2W9TA 3JW5A 1YHOA 1PDBA 4P3RA 1LUDA 8DFRA 4M6LA 1U70A 1DYIA 1IA4A 3D80A 4IXED 3CD2A 3DFRA 4EIGA 3QLYA 4LAGX 3F0QX 1DAJA 2C2SA 2FZJA 3D84X 3NU0A 2L28A 4KJLA 4FHBA 5FDAA 2DHFA 3S3VA 3QYOA 4QLGA 4PTHA 3IROA 1DR4A 3JWFA 3TQ8A 4EIZA 3FQOA 1DRHA 4KJJA 3R33A 4OSGA 4QLFA 4TU5X 1DYRA 2B3ZA 1DR7A 4XT5A 1RC4A 4XT8A 3FRBX 2KGKA 3SQYX 1HFPA 5HUIA 3NZCX 3EEMA 3SR5X 5HT5A 1IA3A 1RX6A 2HM9A 3K45A 3SRQX 4X5JA 4KL9A 3FQ0A 3EEKA 3FQVA 4H95A 3L3RA 1CD2A 1RB3A 5HVEA 1D1GA 4G3MA 4XRBA 4H98A 4ELBA 4G8ZX 5HPBA 4KM0A 4PSTA 1DDRA 4Q67A 3JVXA 4PTJA 1HFQA 3NTZA 1S3WA 1AOEA 3DG8A 3FQZA 4X5HA 5HF0X 3FY9X 4XT7A 3FRAX 1RX3A 3F91A 3UM5A 4HA7A 3F8YA 1DRAA 3EIGA 5DFRA 4ECKA 4RGCA 2XW7A 2BLCA 3JWKA 3SRRX 3KFYA 3LG4A 4DPDA 3S9UA 1RA2A 3FYVX 1RX9A 4KYAA 1RE7A 4DPHA 3F8ZA 1DG5A 3QL0A 4CD2A 1QZFA 1DG8A 3EEJA 3QLWA 4M7VA 1MVTA 3NXOA 4PSYA 3FYWX 1RX1A 4KNEA 4LEKX 2FZHA 3DGAA 4IXGX 4XT4A 1RF7A 5E8QA 1DR3A 4X5IA 4KBNA 5ECXA 3GYFA 1J3KA 1IA1A 1SEJA 4M6KA 4XECX 3NXRA 3ROAA 2W3VA 3I8AX 3QLSA 1HFRA 3DRCA 5HF2X 3DAUA 3QLZA 2OBCA 4Q6AA 2W3BA 3SGYA 3CLBA 3NXXA 3KJSA 3M09A 2ITHA 3K47A 5HVBA 4P3QA 1S3YA 3IA5A 3NRRA 3TD8A 3QLRA 2W9HA 4NX7A 2AZNA 3NXTA 1RA9A 3GI2A 2G6VA 3NZBX 1DISA 3I3RA 4LAHX 1E26A 1RX2A 1RX5A 1JOMA 3DATA 5U26A 2ANOA 5DXVA 2H2QA 1OHKA 5ECCA 5U27A 4ELEA 4HOFA 1DR5A 2CIGA 3SH2A 3NZAX 3IX9A 2OIPA 1DRFA 1S3UA 1M78A 1OHJA 1KMVA 3CL9A 5HI6A 3ZPCA 1DHIA 4M7UA 3F0UX 3JSUA 1DG7A 3S7AA 3TQAA 2BLBA 5HQYA 2HQPA 3QYLA 1DDSA 3SA2A 4PSSA 4GH8A 1RH3A 1U72A 1DHJA 3UM6A 2INQA 3QG2A 3UM8A 2BLAA 3INVA 3VCOA 3GHWA 4FGHA 3TQBA 2O7PA 4XE6X 4QHVA 3CSEA 3FQCA 3JTWA 2D5NA 2HXVA 1JOLA 4HOEA 3OCHA 4KD7A 5HQZA 4QLEA 3DL6A 3SA1A 4KEBA 3IRMA 2P4GA 3QLXA 5HSRA 1DHFA 1AI9A 4KY8A 4H97A 3SRSX 1PD9A 4I13A 4OR7A 3F0SX 3FY8X 4KJKA 4KLXA 1JUVA 4I1NA 1DR1A 3DL5A 2GD9A 3KJRA 1VJ3A 1S3VA 3JWMA 4PDJA 1ZDRA 2W9SA 1J3IA 1RX7A 3E0BA 3SAIA 3IRNA 3OAFA 2W3WA 4M2XA 1DYJA 3QL3A 4P66A 3HBBA 2CD2A 3FL8A 4G95A 5HT4A 1BZFA 4H96A 3FL9A 3KGYA 3NZ9X 1TDRA 2DRCA 5CCCA 1DIUA 1BOZA 5JA3A 1CZ3A 3M08A 3GHVA 4FGGA 4KY4A 3QFXA 3SRUX 4EJ1A 4ELFA 3GHCA 3N0HA 4X5GA 3Q1HA 4KAKA 3SRWX 1M79A 4KM2A 1RD7A 4X5FA 1MVSA 1RG7A 1RX8A 2W3AA 4DDRA
chains in the Genus database with same CATH topology
3TQ9A 1DLSA 1M7AA 2W3MA 4XT6A 1KLKA 4NX6A 3JWCA 4ELGA 3FRFX 3EX8A 6DFRA 2ANQA 2ZZAA 4ELHA 5JG0X 4DP3A 5CC9A 2W9GA 1DR2A 4QJZD 1DRBA 3F0VX 2D0KA 5EAJA 3NZ6X 3FQFA 1LY4A 3F0XX 4IXFX 3RG9A 2FZIA 4P68A 1AO8A 4QI9A 3KY8A 3NXVA 1RA3A 2BL9A 5HSUA 3HJ3A 3FS6A 1DR6A 3FRDX 3JW3A 3K74A 2C2TA 4Q0DA 1IA2A 4HA9A 2JYBA 1RA1A 1KMSA 3ZPGA 3IA4A 1RB2A 1PD8A 1DLRA 3QGTA 3K2HA 4QJCA 1U71A 4M6JA 1LY3A 1DYHA 1DF7A 1VDRA 4HOGA 3RO9A 4DFRA 4LAEX 3NZDA 2QK8A 2LF1A 3EELA 4EILA 4Q0EA 1RX4A 7DFRA 4KFJA 3FREX 3F0BX 1J3JA 1RA8A 1DREA 3NXYA 2W9TA 3JW5A 1YHOA 1PDBA 4P3RA 1LUDA 8DFRA 4M6LA 1U70A 1DYIA 1IA4A 3D80A 4IXED 3CD2A 3DFRA 4EIGA 3QLYA 4LAGX 3F0QX 1DAJA 2C2SA 2FZJA 3D84X 3NU0A 2L28A 4KJLA 4FHBA 5FDAA 2DHFA 3S3VA 3QYOA 4QLGA 4PTHA 3IROA 1DR4A 3JWFA 3TQ8A 4EIZA 3FQOA 1DRHA 4KJJA 3R33A 4OSGA 4QLFA 4TU5X 1DYRA 2B3ZA 1DR7A 4XT5A 1RC4A 4XT8A 3FRBX 2KGKA 3SQYX 1HFPA 5HUIA 3NZCX 3EEMA 3SR5X 5HT5A 1IA3A 1RX6A 2HM9A 3K45A 3SRQX 4X5JA 4KL9A 3FQ0A 3EEKA 3FQVA 4H95A 3L3RA 1CD2A 1RB3A 5HVEA 1D1GA 4G3MA 4XRBA 4H98A 4ELBA 4G8ZX 5HPBA 4KM0A 4PSTA 1DDRA 4Q67A 3JVXA 4PTJA 1HFQA 3NTZA 1S3WA 1AOEA 3DG8A 3FQZA 4X5HA 5HF0X 3FY9X 4XT7A 3FRAX 1RX3A 3F91A 3UM5A 4HA7A 3F8YA 1DRAA 3EIGA 5DFRA 4ECKA 4RGCA 2XW7A 2BLCA 3JWKA 3SRRX 3KFYA 3LG4A 4DPDA 3S9UA 1RA2A 3FYVX 1RX9A 4KYAA 1RE7A 4DPHA 3F8ZA 1DG5A 3QL0A 4CD2A 1QZFA 1DG8A 3EEJA 3QLWA 4M7VA 1MVTA 3NXOA 4PSYA 3FYWX 1RX1A 4KNEA 4LEKX 2FZHA 3DGAA 4IXGX 4XT4A 1RF7A 5E8QA 1DR3A 4X5IA 4KBNA 5ECXA 3GYFA 1J3KA 1IA1A 1SEJA 4M6KA 4XECX 3NXRA 3ROAA 2W3VA 3I8AX 3QLSA 1HFRA 3DRCA 5HF2X 3DAUA 3QLZA 2OBCA 4Q6AA 2W3BA 3SGYA 3CLBA 3NXXA 3KJSA 3M09A 2ITHA 3K47A 5HVBA 4P3QA 1S3YA 3IA5A 3NRRA 3TD8A 3QLRA 2W9HA 4NX7A 2AZNA 3NXTA 1RA9A 3GI2A 2G6VA 3NZBX 1DISA 3I3RA 4LAHX 1E26A 1RX2A 1RX5A 1JOMA 3DATA 5U26A 2ANOA 5DXVA 2H2QA 1OHKA 5ECCA 5U27A 4ELEA 4HOFA 1DR5A 2CIGA 3SH2A 3NZAX 3IX9A 2OIPA 1DRFA 1S3UA 1M78A 1OHJA 1KMVA 3CL9A 5HI6A 3ZPCA 1DHIA 4M7UA 3F0UX 3JSUA 1DG7A 3S7AA 3TQAA 2BLBA 5HQYA 2HQPA 3QYLA 1DDSA 3SA2A 4PSSA 4GH8A 1RH3A 1U72A 1DHJA 3UM6A 2INQA 3QG2A 3UM8A 2BLAA 3INVA 3VCOA 3GHWA 4FGHA 3TQBA 2O7PA 4XE6X 4QHVA 3CSEA 3FQCA 3JTWA 2D5NA 2HXVA 1JOLA 4HOEA 3OCHA 4KD7A 5HQZA 4QLEA 3DL6A 3SA1A 4KEBA 3IRMA 2P4GA 3QLXA 5HSRA 1DHFA 1AI9A 4KY8A 4H97A 3SRSX 1PD9A 4I13A 4OR7A 3F0SX 3FY8X 4KJKA 4KLXA 1JUVA 4I1NA 1DR1A 3DL5A 2GD9A 3KJRA 1VJ3A 1S3VA 3JWMA 4PDJA 1ZDRA 2W9SA 1J3IA 1RX7A 3E0BA 3SAIA 3IRNA 3OAFA 2W3WA 4M2XA 1DYJA 3QL3A 4P66A 3HBBA 2CD2A 3FL8A 4G95A 5HT4A 1BZFA 4H96A 3FL9A 3KGYA 3NZ9X 1TDRA 2DRCA 5CCCA 1DIUA 1BOZA 5JA3A 1CZ3A 3M08A 3GHVA 4FGGA 4KY4A 3QFXA 3SRUX 4EJ1A 4ELFA 3GHCA 3N0HA 4X5GA 3Q1HA 4KAKA 3SRWX 1M79A 4KM2A 1RD7A 4X5FA 1MVSA 1RG7A 1RX8A 2W3AA 4DDRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TQ9 A;  1DLS A;  1M7A A;  2W3M A;  4XT6 A;  1KLK A;  4NX6 A;  3JWC A;  4ELG A;  3FRF X;  3EX8 A;  6DFR A;  2ANQ A;  2ZZA A;  4ELH A;  5JG0 X;  4DP3 A;  5CC9 A;  2W9G A;  1DR2 A;  4QJZ D;  1DRB A;  3F0V X;  2D0K A;  5EAJ A;  3NZ6 X;  3FQF A;  1LY4 A;  3F0X X;  4IXF X;  3RG9 A;  2FZI A;  4P68 A;  1AO8 A;  4QI9 A;  3KY8 A;  3NXV A;  1RA3 A;  2BL9 A;  5HSU A;  3HJ3 A;  3FS6 A;  1DR6 A;  3FRD X;  3JW3 A;  3K74 A;  2C2T A;  4Q0D A;  1IA2 A;  4HA9 A;  2JYB A;  1RA1 A;  1KMS A;  3ZPG A;  3IA4 A;  1RB2 A;  1PD8 A;  1DLR A;  3QGT A;  3K2H A;  4QJC A;  1U71 A;  4M6J A;  1LY3 A;  1DYH A;  1DF7 A;  1VDR A;  4HOG A;  3RO9 A;  4DFR A;  4LAE X;  3NZD A;  2QK8 A;  2LF1 A;  3EEL A;  4EIL A;  4Q0E A;  1RX4 A;  7DFR A;  4KFJ A;  3FRE X;  3F0B X;  1J3J A;  1RA8 A;  1DRE A;  3NXY A;  2W9T A;  3JW5 A;  1YHO A;  1PDB A;  4P3R A;  1LUD A;  8DFR A;  4M6L A;  1U70 A;  1DYI A;  1IA4 A;  3D80 A;  4IXE D;  3CD2 A;  3DFR A;  4EIG A;  3QLY A;  4LAG X;  3F0Q X;  1DAJ A;  2C2S A;  2FZJ A;  3D84 X;  3NU0 A;  2L28 A;  4KJL A;  4FHB A;  5FDA A;  2DHF A;  3S3V A;  3QYO A;  4QLG A;  4PTH A;  3IRO A;  1DR4 A;  3JWF A;  3TQ8 A;  4EIZ A;  3FQO A;  1DRH A;  4KJJ A;  3R33 A;  4OSG A;  4QLF A;  4TU5 X;  1DYR A;  2B3Z A;  1DR7 A;  4XT5 A;  1RC4 A;  4XT8 A;  3FRB X;  2KGK A;  3SQY X;  1HFP A;  5HUI A;  3NZC X;  3EEM A;  3SR5 X;  5HT5 A;  1IA3 A;  1RX6 A;  2HM9 A;  3K45 A;  3SRQ X;  4X5J A;  4KL9 A;  3FQ0 A;  3EEK A;  3FQV A;  4H95 A;  3L3R A;  1CD2 A;  1RB3 A;  5HVE A;  1D1G A;  4G3M A;  4XRB A;  4H98 A;  4ELB A;  4G8Z X;  5HPB A;  4KM0 A;  4PST A;  1DDR A;  4Q67 A;  3JVX A;  4PTJ A;  1HFQ A;  3NTZ A;  1S3W A;  1AOE A;  3DG8 A;  3FQZ A;  4X5H A;  5HF0 X;  3FY9 X;  4XT7 A;  3FRA X;  1RX3 A;  3F91 A;  3UM5 A;  4HA7 A;  3F8Y A;  1DRA A;  3EIG A;  5DFR A;  4ECK A;  4RGC A;  2XW7 A;  2BLC A;  3JWK A;  3SRR X;  3KFY A;  3LG4 A;  4DPD A;  3S9U A;  1RA2 A;  3FYV X;  1RX9 A;  4KYA A;  1RE7 A;  4DPH A;  3F8Z A;  1DG5 A;  3QL0 A;  4CD2 A;  1QZF A;  1DG8 A;  3EEJ A;  3QLW A;  4M7V A;  1MVT A;  3NXO A;  4PSY A;  3FYW X;  1RX1 A;  4KNE A;  4LEK X;  2FZH A;  3DGA A;  4IXG X;  4XT4 A;  1RF7 A;  5E8Q A;  1DR3 A;  4X5I A;  4KBN A;  5ECX A;  3GYF A;  1J3K A;  1IA1 A;  1SEJ A;  4M6K A;  4XEC X;  3NXR A;  3ROA A;  2W3V A;  3I8A X;  3QLS A;  1HFR A;  3DRC A;  5HF2 X;  3DAU A;  3QLZ A;  2OBC A;  4Q6A A;  2W3B A;  3SGY A;  3CLB A;  3NXX A;  3KJS A;  3M09 A;  2ITH A;  3K47 A;  5HVB A;  4P3Q A;  1S3Y A;  3IA5 A;  3NRR A;  3TD8 A;  3QLR A;  2W9H A;  4NX7 A;  2AZN A;  3NXT A;  1RA9 A;  3GI2 A;  2G6V A;  3NZB X;  1DIS A;  3I3R A;  4LAH X;  1E26 A;  1RX2 A;  1RX5 A;  1JOM A;  3DAT A;  5U26 A;  2ANO A;  5DXV A;  2H2Q A;  1OHK A;  5ECC A;  5U27 A;  4ELE A;  4HOF A;  1DR5 A;  2CIG A;  3SH2 A;  3NZA X;  3IX9 A;  2OIP A;  1DRF A;  1S3U A;  1M78 A;  1OHJ A;  1KMV A;  3CL9 A;  5HI6 A;  3ZPC A;  1DHI A;  4M7U A;  3F0U X;  3JSU A;  1DG7 A;  3S7A A;  3TQA A;  2BLB A;  5HQY A;  2HQP A;  3QYL A;  1DDS A;  3SA2 A;  4PSS A;  4GH8 A;  1RH3 A;  1U72 A;  1DHJ A;  3UM6 A;  2INQ A;  3QG2 A;  3UM8 A;  2BLA A;  3INV A;  3VCO A;  3GHW A;  4FGH A;  3TQB A;  2O7P A;  4XE6 X;  4QHV A;  3CSE A;  3FQC A;  3JTW A;  2D5N A;  2HXV A;  1JOL A;  4HOE A;  3OCH A;  4KD7 A;  5HQZ A;  4QLE A;  3DL6 A;  3SA1 A;  4KEB A;  3IRM A;  2P4G A;  3QLX A;  5HSR A;  1DHF A;  1AI9 A;  4KY8 A;  4H97 A;  3SRS X;  1PD9 A;  4I13 A;  4OR7 A;  3F0S X;  3FY8 X;  4KJK A;  4KLX A;  1JUV A;  4I1N A;  1DR1 A;  3DL5 A;  2GD9 A;  3KJR A;  1VJ3 A;  1S3V A;  3JWM A;  4PDJ A;  1ZDR A;  2W9S A;  1J3I A;  1RX7 A;  3E0B A;  3SAI A;  3IRN A;  3OAF A;  2W3W A;  4M2X A;  1DYJ A;  3QL3 A;  4P66 A;  3HBB A;  2CD2 A;  3FL8 A;  4G95 A;  5HT4 A;  1BZF A;  4H96 A;  3FL9 A;  3KGY A;  3NZ9 X;  1TDR A;  2DRC A;  5CCC A;  1DIU A;  1BOZ A;  5JA3 A;  1CZ3 A;  3M08 A;  3GHV A;  4FGG A;  4KY4 A;  3QFX A;  3SRU X;  4EJ1 A;  4ELF A;  3GHC A;  3N0H A;  4X5G A;  3Q1H A;  4KAK A;  3SRW X;  1M79 A;  4KM2 A;  1RD7 A;  4X5F A;  1MVS A;  1RG7 A;  1RX8 A;  2W3A A;  4DDR A; 
#chains in the Genus database with same CATH topology
 3TQ9 A;  1DLS A;  1M7A A;  2W3M A;  4XT6 A;  1KLK A;  4NX6 A;  3JWC A;  4ELG A;  3FRF X;  3EX8 A;  6DFR A;  2ANQ A;  2ZZA A;  4ELH A;  5JG0 X;  4DP3 A;  5CC9 A;  2W9G A;  1DR2 A;  4QJZ D;  1DRB A;  3F0V X;  2D0K A;  5EAJ A;  3NZ6 X;  3FQF A;  1LY4 A;  3F0X X;  4IXF X;  3RG9 A;  2FZI A;  4P68 A;  1AO8 A;  4QI9 A;  3KY8 A;  3NXV A;  1RA3 A;  2BL9 A;  5HSU A;  3HJ3 A;  3FS6 A;  1DR6 A;  3FRD X;  3JW3 A;  3K74 A;  2C2T A;  4Q0D A;  1IA2 A;  4HA9 A;  2JYB A;  1RA1 A;  1KMS A;  3ZPG A;  3IA4 A;  1RB2 A;  1PD8 A;  1DLR A;  3QGT A;  3K2H A;  4QJC A;  1U71 A;  4M6J A;  1LY3 A;  1DYH A;  1DF7 A;  1VDR A;  4HOG A;  3RO9 A;  4DFR A;  4LAE X;  3NZD A;  2QK8 A;  2LF1 A;  3EEL A;  4EIL A;  4Q0E A;  1RX4 A;  7DFR A;  4KFJ A;  3FRE X;  3F0B X;  1J3J A;  1RA8 A;  1DRE A;  3NXY A;  2W9T A;  3JW5 A;  1YHO A;  1PDB A;  4P3R A;  1LUD A;  8DFR A;  4M6L A;  1U70 A;  1DYI A;  1IA4 A;  3D80 A;  4IXE D;  3CD2 A;  3DFR A;  4EIG A;  3QLY A;  4LAG X;  3F0Q X;  1DAJ A;  2C2S A;  2FZJ A;  3D84 X;  3NU0 A;  2L28 A;  4KJL A;  4FHB A;  5FDA A;  2DHF A;  3S3V A;  3QYO A;  4QLG A;  4PTH A;  3IRO A;  1DR4 A;  3JWF A;  3TQ8 A;  4EIZ A;  3FQO A;  1DRH A;  4KJJ A;  3R33 A;  4OSG A;  4QLF A;  4TU5 X;  1DYR A;  2B3Z A;  1DR7 A;  4XT5 A;  1RC4 A;  4XT8 A;  3FRB X;  2KGK A;  3SQY X;  1HFP A;  5HUI A;  3NZC X;  3EEM A;  3SR5 X;  5HT5 A;  1IA3 A;  1RX6 A;  2HM9 A;  3K45 A;  3SRQ X;  4X5J A;  4KL9 A;  3FQ0 A;  3EEK A;  3FQV A;  4H95 A;  3L3R A;  1CD2 A;  1RB3 A;  5HVE A;  1D1G A;  4G3M A;  4XRB A;  4H98 A;  4ELB A;  4G8Z X;  5HPB A;  4KM0 A;  4PST A;  1DDR A;  4Q67 A;  3JVX A;  4PTJ A;  1HFQ A;  3NTZ A;  1S3W A;  1AOE A;  3DG8 A;  3FQZ A;  4X5H A;  5HF0 X;  3FY9 X;  4XT7 A;  3FRA X;  1RX3 A;  3F91 A;  3UM5 A;  4HA7 A;  3F8Y A;  1DRA A;  3EIG A;  5DFR A;  4ECK A;  4RGC A;  2XW7 A;  2BLC A;  3JWK A;  3SRR X;  3KFY A;  3LG4 A;  4DPD A;  3S9U A;  1RA2 A;  3FYV X;  1RX9 A;  4KYA A;  1RE7 A;  4DPH A;  3F8Z A;  1DG5 A;  3QL0 A;  4CD2 A;  1QZF A;  1DG8 A;  3EEJ A;  3QLW A;  4M7V A;  1MVT A;  3NXO A;  4PSY A;  3FYW X;  1RX1 A;  4KNE A;  4LEK X;  2FZH A;  3DGA A;  4IXG X;  4XT4 A;  1RF7 A;  5E8Q A;  1DR3 A;  4X5I A;  4KBN A;  5ECX A;  3GYF A;  1J3K A;  1IA1 A;  1SEJ A;  4M6K A;  4XEC X;  3NXR A;  3ROA A;  2W3V A;  3I8A X;  3QLS A;  1HFR A;  3DRC A;  5HF2 X;  3DAU A;  3QLZ A;  2OBC A;  4Q6A A;  2W3B A;  3SGY A;  3CLB A;  3NXX A;  3KJS A;  3M09 A;  2ITH A;  3K47 A;  5HVB A;  4P3Q A;  1S3Y A;  3IA5 A;  3NRR A;  3TD8 A;  3QLR A;  2W9H A;  4NX7 A;  2AZN A;  3NXT A;  1RA9 A;  3GI2 A;  2G6V A;  3NZB X;  1DIS A;  3I3R A;  4LAH X;  1E26 A;  1RX2 A;  1RX5 A;  1JOM A;  3DAT A;  5U26 A;  2ANO A;  5DXV A;  2H2Q A;  1OHK A;  5ECC A;  5U27 A;  4ELE A;  4HOF A;  1DR5 A;  2CIG A;  3SH2 A;  3NZA X;  3IX9 A;  2OIP A;  1DRF A;  1S3U A;  1M78 A;  1OHJ A;  1KMV A;  3CL9 A;  5HI6 A;  3ZPC A;  1DHI A;  4M7U A;  3F0U X;  3JSU A;  1DG7 A;  3S7A A;  3TQA A;  2BLB A;  5HQY A;  2HQP A;  3QYL A;  1DDS A;  3SA2 A;  4PSS A;  4GH8 A;  1RH3 A;  1U72 A;  1DHJ A;  3UM6 A;  2INQ A;  3QG2 A;  3UM8 A;  2BLA A;  3INV A;  3VCO A;  3GHW A;  4FGH A;  3TQB A;  2O7P A;  4XE6 X;  4QHV A;  3CSE A;  3FQC A;  3JTW A;  2D5N A;  2HXV A;  1JOL A;  4HOE A;  3OCH A;  4KD7 A;  5HQZ A;  4QLE A;  3DL6 A;  3SA1 A;  4KEB A;  3IRM A;  2P4G A;  3QLX A;  5HSR A;  1DHF A;  1AI9 A;  4KY8 A;  4H97 A;  3SRS X;  1PD9 A;  4I13 A;  4OR7 A;  3F0S X;  3FY8 X;  4KJK A;  4KLX A;  1JUV A;  4I1N A;  1DR1 A;  3DL5 A;  2GD9 A;  3KJR A;  1VJ3 A;  1S3V A;  3JWM A;  4PDJ A;  1ZDR A;  2W9S A;  1J3I A;  1RX7 A;  3E0B A;  3SAI A;  3IRN A;  3OAF A;  2W3W A;  4M2X A;  1DYJ A;  3QL3 A;  4P66 A;  3HBB A;  2CD2 A;  3FL8 A;  4G95 A;  5HT4 A;  1BZF A;  4H96 A;  3FL9 A;  3KGY A;  3NZ9 X;  1TDR A;  2DRC A;  5CCC A;  1DIU A;  1BOZ A;  5JA3 A;  1CZ3 A;  3M08 A;  3GHV A;  4FGG A;  4KY4 A;  3QFX A;  3SRU X;  4EJ1 A;  4ELF A;  3GHC A;  3N0H A;  4X5G A;  3Q1H A;  4KAK A;  3SRW X;  1M79 A;  4KM2 A;  1RD7 A;  4X5F A;  1MVS A;  1RG7 A;  1RX8 A;  2W3A A;  4DDR A; 
#chains in the Genus database with same CATH homology
 3TQ9 A;  1DLS A;  1M7A A;  2W3M A;  4XT6 A;  1KLK A;  4NX6 A;  3JWC A;  4ELG A;  3FRF X;  3EX8 A;  6DFR A;  2ANQ A;  2ZZA A;  4ELH A;  5JG0 X;  4DP3 A;  5CC9 A;  2W9G A;  1DR2 A;  4QJZ D;  1DRB A;  3F0V X;  2D0K A;  5EAJ A;  3NZ6 X;  3FQF A;  1LY4 A;  3F0X X;  4IXF X;  3RG9 A;  2FZI A;  4P68 A;  1AO8 A;  4QI9 A;  3KY8 A;  3NXV A;  1RA3 A;  2BL9 A;  5HSU A;  3HJ3 A;  3FS6 A;  1DR6 A;  3FRD X;  3JW3 A;  3K74 A;  2C2T A;  4Q0D A;  1IA2 A;  4HA9 A;  2JYB A;  1RA1 A;  1KMS A;  3ZPG A;  3IA4 A;  1RB2 A;  1PD8 A;  1DLR A;  3QGT A;  3K2H A;  4QJC A;  1U71 A;  4M6J A;  1LY3 A;  1DYH A;  1DF7 A;  1VDR A;  4HOG A;  3RO9 A;  4DFR A;  4LAE X;  3NZD A;  2QK8 A;  2LF1 A;  3EEL A;  4EIL A;  4Q0E A;  1RX4 A;  7DFR A;  4KFJ A;  3FRE X;  3F0B X;  1J3J A;  1RA8 A;  1DRE A;  3NXY A;  2W9T A;  3JW5 A;  1YHO A;  1PDB A;  4P3R A;  1LUD A;  8DFR A;  4M6L A;  1U70 A;  1DYI A;  1IA4 A;  3D80 A;  4IXE D;  3CD2 A;  3DFR A;  4EIG A;  3QLY A;  4LAG X;  3F0Q X;  1DAJ A;  2C2S A;  2FZJ A;  3D84 X;  3NU0 A;  2L28 A;  4KJL A;  4FHB A;  5FDA A;  2DHF A;  3S3V A;  3QYO A;  4QLG A;  4PTH A;  3IRO A;  1DR4 A;  3JWF A;  3TQ8 A;  4EIZ A;  3FQO A;  1DRH A;  4KJJ A;  3R33 A;  4OSG A;  4QLF A;  4TU5 X;  1DYR A;  2B3Z A;  1DR7 A;  4XT5 A;  1RC4 A;  4XT8 A;  3FRB X;  2KGK A;  3SQY X;  1HFP A;  5HUI A;  3NZC X;  3EEM A;  3SR5 X;  5HT5 A;  1IA3 A;  1RX6 A;  2HM9 A;  3K45 A;  3SRQ X;  4X5J A;  4KL9 A;  3FQ0 A;  3EEK A;  3FQV A;  4H95 A;  3L3R A;  1CD2 A;  1RB3 A;  5HVE A;  1D1G A;  4G3M A;  4XRB A;  4H98 A;  4ELB A;  4G8Z X;  5HPB A;  4KM0 A;  4PST A;  1DDR A;  4Q67 A;  3JVX A;  4PTJ A;  1HFQ A;  3NTZ A;  1S3W A;  1AOE A;  3DG8 A;  3FQZ A;  4X5H A;  5HF0 X;  3FY9 X;  4XT7 A;  3FRA X;  1RX3 A;  3F91 A;  3UM5 A;  4HA7 A;  3F8Y A;  1DRA A;  3EIG A;  5DFR A;  4ECK A;  4RGC A;  2XW7 A;  2BLC A;  3JWK A;  3SRR X;  3KFY A;  3LG4 A;  4DPD A;  3S9U A;  1RA2 A;  3FYV X;  1RX9 A;  4KYA A;  1RE7 A;  4DPH A;  3F8Z A;  1DG5 A;  3QL0 A;  4CD2 A;  1QZF A;  1DG8 A;  3EEJ A;  3QLW A;  4M7V A;  1MVT A;  3NXO A;  4PSY A;  3FYW X;  1RX1 A;  4KNE A;  4LEK X;  2FZH A;  3DGA A;  4IXG X;  4XT4 A;  1RF7 A;  5E8Q A;  1DR3 A;  4X5I A;  4KBN A;  5ECX A;  3GYF A;  1J3K A;  1IA1 A;  1SEJ A;  4M6K A;  4XEC X;  3NXR A;  3ROA A;  2W3V A;  3I8A X;  3QLS A;  1HFR A;  3DRC A;  5HF2 X;  3DAU A;  3QLZ A;  2OBC A;  4Q6A A;  2W3B A;  3SGY A;  3CLB A;  3NXX A;  3KJS A;  3M09 A;  2ITH A;  3K47 A;  5HVB A;  4P3Q A;  1S3Y A;  3IA5 A;  3NRR A;  3TD8 A;  3QLR A;  2W9H A;  4NX7 A;  2AZN A;  3NXT A;  1RA9 A;  3GI2 A;  2G6V A;  3NZB X;  1DIS A;  3I3R A;  4LAH X;  1E26 A;  1RX2 A;  1RX5 A;  1JOM A;  3DAT A;  5U26 A;  2ANO A;  5DXV A;  2H2Q A;  1OHK A;  5ECC A;  5U27 A;  4ELE A;  4HOF A;  1DR5 A;  2CIG A;  3SH2 A;  3NZA X;  3IX9 A;  2OIP A;  1DRF A;  1S3U A;  1M78 A;  1OHJ A;  1KMV A;  3CL9 A;  5HI6 A;  3ZPC A;  1DHI A;  4M7U A;  3F0U X;  3JSU A;  1DG7 A;  3S7A A;  3TQA A;  2BLB A;  5HQY A;  2HQP A;  3QYL A;  1DDS A;  3SA2 A;  4PSS A;  4GH8 A;  1RH3 A;  1U72 A;  1DHJ A;  3UM6 A;  2INQ A;  3QG2 A;  3UM8 A;  2BLA A;  3INV A;  3VCO A;  3GHW A;  4FGH A;  3TQB A;  2O7P A;  4XE6 X;  4QHV A;  3CSE A;  3FQC A;  3JTW A;  2D5N A;  2HXV A;  1JOL A;  4HOE A;  3OCH A;  4KD7 A;  5HQZ A;  4QLE A;  3DL6 A;  3SA1 A;  4KEB A;  3IRM A;  2P4G A;  3QLX A;  5HSR A;  1DHF A;  1AI9 A;  4KY8 A;  4H97 A;  3SRS X;  1PD9 A;  4I13 A;  4OR7 A;  3F0S X;  3FY8 X;  4KJK A;  4KLX A;  1JUV A;  4I1N A;  1DR1 A;  3DL5 A;  2GD9 A;  3KJR A;  1VJ3 A;  1S3V A;  3JWM A;  4PDJ A;  1ZDR A;  2W9S A;  1J3I A;  1RX7 A;  3E0B A;  3SAI A;  3IRN A;  3OAF A;  2W3W A;  4M2X A;  1DYJ A;  3QL3 A;  4P66 A;  3HBB A;  2CD2 A;  3FL8 A;  4G95 A;  5HT4 A;  1BZF A;  4H96 A;  3FL9 A;  3KGY A;  3NZ9 X;  1TDR A;  2DRC A;  5CCC A;  1DIU A;  1BOZ A;  5JA3 A;  1CZ3 A;  3M08 A;  3GHV A;  4FGG A;  4KY4 A;  3QFX A;  3SRU X;  4EJ1 A;  4ELF A;  3GHC A;  3N0H A;  4X5G A;  3Q1H A;  4KAK A;  3SRW X;  1M79 A;  4KM2 A;  1RD7 A;  4X5F A;  1MVS A;  1RG7 A;  1RX8 A;  2W3A A;  4DDR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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