4P3QA

Room-temperature wt dhfr, time-averaged ensemble
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Crystal Cryocooling Distorts Conformational Heterogeneity in a Model Michaelis Complex of DHFR.
pubmed doi rcsb
molecule keywords Dihydrofolate reductase
molecule tags Oxidoreductase
source organism Escherichia coli
total genus 38
structure length 159
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2014-03-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4p3qA00
3FL8A 4KBNA 1J3IA 4DDRA 4P66A 1QZFA 4I1NA 4OR7A 4KM0A 3I8AX 3F0XX 3K45A 4DFRA 4X5FA 4HA7A 3QLXA 1VDRA 3CD2A 1J3JA 3JTWA 4QHVA 4M2XA 2D0KA 1LUDA 1SEJA 2P4GA 4ECKA 2OIPA 4IXGX 3NTZA 5U26A 1PD9A 4M7UA 1RD7A 3FQOA 3JW5A 3NZBX 4KLXA 4XT7A 1DF7A 3OCHA 1DHIA 3NXVA 1DR7A 3S3VA 3FL9A 5HVEA 3NXYA 3DGAA 4EJ1A 3S9UA 1AO8A 3SA2A 3NXTA 1DLRA 5HT4A 3QLRA 3K47A 1RX6A 3DL6A 3QLWA 1BOZA 4KY4A 4X5GA 5CC9A 1M78A 5HF2X 1DG8A 4XRBA 1RX4A 1MVTA 3JWFA 3UM8A 2BLBA 1KMVA 1RA9A 3ZPGA 3F0VX 4XT5A 1PDBA 2H2QA 4HOFA 1DDSA 3RG9A 1DR3A 1S3UA 4PTJA 3TQBA 1OHKA 4XT8A 1JUVA 3FQFA 4LAGX 1D1GA 5ECXA 3DATA 3F0UX 3FRBX 4X5IA 2GD9A 4QJZD 3JWKA 5E8QA 8DFRA 4ELFA 4KAKA 3UM5A 1LY4A 3NRRA 3FYWX 2W9HA 3F91A 3EIGA 2G6VA 2CIGA 3DG8A 4KYAA 4DPHA 1CD2A 5DXVA 2INQA 1DG5A 3FY8X 3KFYA 6DFRA 2DHFA 3INVA 4LAHX 3UM6A 4GH8A 1U72A 1DYRA 1S3YA 1DISA 1DRHA 4M6JA 1RX2A 1IA4A 4ELBA 3TQ9A 4PDJA 2B3ZA 3VCOA 3HJ3A 3GHCA 5HQYA 4XECX 4X5JA 3GI2A 4XT6A 4H98A 2HXVA 3I3RA 3FRFX 1RB3A 1BZFA 4QJCA 3FS6A 3SR5X 4X5HA 3FQ0A 2BLCA 1RX8A 2W9TA 1IA1A 2W9GA 3FQVA 3TQAA 3CL9A 1KLKA 3F0SX 3M08A 3Q1HA 3N0HA 3GYFA 1RX1A 1JOMA 5HSRA 1IA2A 1DYIA 4EIZA 1VJ3A 2W3MA 4Q0DA 2W3AA 5DFRA 2XW7A 5HVBA 1JOLA 4HOEA 4FHBA 3DFRA 4NX7A 3EEMA 3IRNA 3JWMA 4P68A 4KJKA 3QYOA 4EIGA 3DRCA 4H97A 4KM2A 5HUIA 3F0BX 3FRAX 3SGYA 3IX9A 4P3QA 3FY9X 3NZAX 5HSUA 1DYJA 4Q0EA 4KJLA 1DR2A 3SRSX 3SAIA 4Q6AA 3L3RA 3DL5A 4G3MA 4I13A 1DR5A 3E0BA 2W3BA 4KEBA 3GHVA 3QLZA 4KY8A 4KNEA 3QL0A 3QYLA 4G8ZX 2OBCA 3SRRX 4XE6X 3SH2A 1RB2A 4PSTA 3ZPCA 3CSEA 3OAFA 4QLGA 4M7VA 3IROA 7DFRA 3FRDX 1U70A 1HFQA 3R33A 1HFRA 2JYBA 4PSSA 1KMSA 3TD8A 4DPDA 5HF0X 4HA9A 3FREX 4QI9A 1OHJA 1YHOA 5JG0X 3JW3A 1RE7A 1RX9A 3QL3A 3RO9A 1DRBA 4ELGA 2FZHA 3EEJA 3IA5A 3K2HA 2O7PA 3FQZA 4KFJA 3JSUA 4RGCA 4KL9A 5HT5A 3F8ZA 3HBBA 3KY8A 1RX7A 1RA1A 3QLSA 3SA1A 1RA2A 5HI6A 4M6LA 4PSYA 2C2TA 3F8YA 2LF1A 3NXRA 1RX3A 2CD2A 3SRWX 1DR1A 4M6KA 4DP3A 3JWCA 5JA3A 1RH3A 1TDRA 4OSGA 3NXXA 2D5NA 1DHFA 1PD8A 3EX8A 3ROAA 5FDAA 3SQYX 3QLYA 4EILA 3FYVX 3IA4A 1J3KA 2FZIA 3NZDA 1RC4A 3S7AA 1DR6A 3EELA 1M7AA 1CZ3A 5U27A 3DAUA 3QGTA 4H96A 2ZZAA 4TU5X 3D80A 1M79A 3KJSA 4QLEA 1LY3A 3EEKA 4LEKX 1RA8A 2KGKA 5HQZA 1MVSA 1DAJA 5CCCA 2BLAA 3SRUX 3F0QX 3QFXA 3GHWA 1RX5A 2AZNA 1S3VA 1DG7A 1DLSA 1DRFA 1E26A 4H95A 2ITHA 1RF7A 4Q67A 4HOGA 1DIUA 2HQPA 4PTHA 4ELHA 3NZ9X 3NZCX 1AI9A 3CLBA 4IXED 2BL9A 3D84X 4CD2A 1AOEA 3K74A 4KJJA 3FQCA 4ELEA 4FGHA 2FZJA 2W3VA 2W3WA 2HM9A 3SRQX 2ANOA 1IA3A 1U71A 3JVXA 1DDRA 4P3RA 5HPBA 3IRMA 1HFPA 4IXFX 4NX6A 2DRCA 2ANQA 5ECCA 1RA3A 1ZDRA 2W9SA 2L28A 4LAEX 3M09A 3QG2A 1S3WA 4KD7A 1DREA 4XT4A 1DHJA 3LG4A 1DRAA 1DYHA 3TQ8A 4FGGA 3KGYA 1DR4A 3KJRA 1RG7A 3NZ6X 2C2SA 3NXOA 2QK8A 3NU0A 4QLFA 5EAJA 4G95A
chains in the Genus database with same CATH superfamily
3FL8A 4KBNA 1J3IA 4DDRA 4P66A 1QZFA 4I1NA 4OR7A 4KM0A 3I8AX 3F0XX 3K45A 4DFRA 4X5FA 4HA7A 3QLXA 1VDRA 3CD2A 1J3JA 3JTWA 4QHVA 4M2XA 2D0KA 1LUDA 1SEJA 2P4GA 4ECKA 2OIPA 4IXGX 3NTZA 5U26A 1PD9A 4M7UA 1RD7A 3FQOA 3JW5A 3NZBX 4KLXA 4XT7A 1DF7A 3OCHA 1DHIA 3NXVA 1DR7A 3S3VA 3FL9A 5HVEA 3NXYA 3DGAA 4EJ1A 3S9UA 1AO8A 3SA2A 3NXTA 1DLRA 5HT4A 3QLRA 3K47A 1RX6A 3DL6A 3QLWA 1BOZA 4KY4A 4X5GA 5CC9A 1M78A 5HF2X 1DG8A 4XRBA 1RX4A 1MVTA 3JWFA 3UM8A 2BLBA 1KMVA 1RA9A 3ZPGA 3F0VX 4XT5A 1PDBA 2H2QA 4HOFA 1DDSA 3RG9A 1DR3A 1S3UA 4PTJA 3TQBA 1OHKA 4XT8A 1JUVA 3FQFA 4LAGX 1D1GA 5ECXA 3DATA 3F0UX 3FRBX 4X5IA 2GD9A 4QJZD 3JWKA 5E8QA 8DFRA 4ELFA 4KAKA 3UM5A 1LY4A 3NRRA 3FYWX 2W9HA 3F91A 3EIGA 2G6VA 2CIGA 3DG8A 4KYAA 4DPHA 1CD2A 5DXVA 2INQA 1DG5A 3FY8X 3KFYA 6DFRA 2DHFA 3INVA 4LAHX 3UM6A 4GH8A 1U72A 1DYRA 1S3YA 1DISA 1DRHA 4M6JA 1RX2A 1IA4A 4ELBA 3TQ9A 4PDJA 2B3ZA 3VCOA 3HJ3A 3GHCA 5HQYA 4XECX 4X5JA 3GI2A 4XT6A 4H98A 2HXVA 3I3RA 3FRFX 1RB3A 1BZFA 4QJCA 3FS6A 3SR5X 4X5HA 3FQ0A 2BLCA 1RX8A 2W9TA 1IA1A 2W9GA 3FQVA 3TQAA 3CL9A 1KLKA 3F0SX 3M08A 3Q1HA 3N0HA 3GYFA 1RX1A 1JOMA 5HSRA 1IA2A 1DYIA 4EIZA 1VJ3A 2W3MA 4Q0DA 2W3AA 5DFRA 2XW7A 5HVBA 1JOLA 4HOEA 4FHBA 3DFRA 4NX7A 3EEMA 3IRNA 3JWMA 4P68A 4KJKA 3QYOA 4EIGA 3DRCA 4H97A 4KM2A 5HUIA 3F0BX 3FRAX 3SGYA 3IX9A 4P3QA 3FY9X 3NZAX 5HSUA 1DYJA 4Q0EA 4KJLA 1DR2A 3SRSX 3SAIA 4Q6AA 3L3RA 3DL5A 4G3MA 4I13A 1DR5A 3E0BA 2W3BA 4KEBA 3GHVA 3QLZA 4KY8A 4KNEA 3QL0A 3QYLA 4G8ZX 2OBCA 3SRRX 4XE6X 3SH2A 1RB2A 4PSTA 3ZPCA 3CSEA 3OAFA 4QLGA 4M7VA 3IROA 7DFRA 3FRDX 1U70A 1HFQA 3R33A 1HFRA 2JYBA 4PSSA 1KMSA 3TD8A 4DPDA 5HF0X 4HA9A 3FREX 4QI9A 1OHJA 1YHOA 5JG0X 3JW3A 1RE7A 1RX9A 3QL3A 3RO9A 1DRBA 4ELGA 2FZHA 3EEJA 3IA5A 3K2HA 2O7PA 3FQZA 4KFJA 3JSUA 4RGCA 4KL9A 5HT5A 3F8ZA 3HBBA 3KY8A 1RX7A 1RA1A 3QLSA 3SA1A 1RA2A 5HI6A 4M6LA 4PSYA 2C2TA 3F8YA 2LF1A 3NXRA 1RX3A 2CD2A 3SRWX 1DR1A 4M6KA 4DP3A 3JWCA 5JA3A 1RH3A 1TDRA 4OSGA 3NXXA 2D5NA 1DHFA 1PD8A 3EX8A 3ROAA 5FDAA 3SQYX 3QLYA 4EILA 3FYVX 3IA4A 1J3KA 2FZIA 3NZDA 1RC4A 3S7AA 1DR6A 3EELA 1M7AA 1CZ3A 5U27A 3DAUA 3QGTA 4H96A 2ZZAA 4TU5X 3D80A 1M79A 3KJSA 4QLEA 1LY3A 3EEKA 4LEKX 1RA8A 2KGKA 5HQZA 1MVSA 1DAJA 5CCCA 2BLAA 3SRUX 3F0QX 3QFXA 3GHWA 1RX5A 2AZNA 1S3VA 1DG7A 1DLSA 1DRFA 1E26A 4H95A 2ITHA 1RF7A 4Q67A 4HOGA 1DIUA 2HQPA 4PTHA 4ELHA 3NZ9X 3NZCX 1AI9A 3CLBA 4IXED 2BL9A 3D84X 4CD2A 1AOEA 3K74A 4KJJA 3FQCA 4ELEA 4FGHA 2FZJA 2W3VA 2W3WA 2HM9A 3SRQX 2ANOA 1IA3A 1U71A 3JVXA 1DDRA 4P3RA 5HPBA 3IRMA 1HFPA 4IXFX 4NX6A 2DRCA 2ANQA 5ECCA 1RA3A 1ZDRA 2W9SA 2L28A 4LAEX 3M09A 3QG2A 1S3WA 4KD7A 1DREA 4XT4A 1DHJA 3LG4A 1DRAA 1DYHA 3TQ8A 4FGGA 3KGYA 1DR4A 3KJRA 1RG7A 3NZ6X 2C2SA 3NXOA 2QK8A 3NU0A 4QLFA 5EAJA 4G95A
chains in the Genus database with same CATH topology
3FL8A 4KBNA 1J3IA 4DDRA 4P66A 1QZFA 4I1NA 4OR7A 4KM0A 3I8AX 3F0XX 3K45A 4DFRA 4X5FA 4HA7A 3QLXA 1VDRA 3CD2A 1J3JA 3JTWA 4QHVA 4M2XA 2D0KA 1LUDA 1SEJA 2P4GA 4ECKA 2OIPA 4IXGX 3NTZA 5U26A 1PD9A 4M7UA 1RD7A 3FQOA 3JW5A 3NZBX 4KLXA 4XT7A 1DF7A 3OCHA 1DHIA 3NXVA 1DR7A 3S3VA 3FL9A 5HVEA 3NXYA 3DGAA 4EJ1A 3S9UA 1AO8A 3SA2A 3NXTA 1DLRA 5HT4A 3QLRA 3K47A 1RX6A 3DL6A 3QLWA 1BOZA 4KY4A 4X5GA 5CC9A 1M78A 5HF2X 1DG8A 4XRBA 1RX4A 1MVTA 3JWFA 3UM8A 2BLBA 1KMVA 1RA9A 3ZPGA 3F0VX 4XT5A 1PDBA 2H2QA 4HOFA 1DDSA 3RG9A 1DR3A 1S3UA 4PTJA 3TQBA 1OHKA 4XT8A 1JUVA 3FQFA 4LAGX 1D1GA 5ECXA 3DATA 3F0UX 3FRBX 4X5IA 2GD9A 4QJZD 3JWKA 5E8QA 8DFRA 4ELFA 4KAKA 3UM5A 1LY4A 3NRRA 3FYWX 2W9HA 3F91A 3EIGA 2G6VA 2CIGA 3DG8A 4KYAA 4DPHA 1CD2A 5DXVA 2INQA 1DG5A 3FY8X 3KFYA 6DFRA 2DHFA 3INVA 4LAHX 3UM6A 4GH8A 1U72A 1DYRA 1S3YA 1DISA 1DRHA 4M6JA 1RX2A 1IA4A 4ELBA 3TQ9A 4PDJA 2B3ZA 3VCOA 3HJ3A 3GHCA 5HQYA 4XECX 4X5JA 3GI2A 4XT6A 4H98A 2HXVA 3I3RA 3FRFX 1RB3A 1BZFA 4QJCA 3FS6A 3SR5X 4X5HA 3FQ0A 2BLCA 1RX8A 2W9TA 1IA1A 2W9GA 3FQVA 3TQAA 3CL9A 1KLKA 3F0SX 3M08A 3Q1HA 3N0HA 3GYFA 1RX1A 1JOMA 5HSRA 1IA2A 1DYIA 4EIZA 1VJ3A 2W3MA 4Q0DA 2W3AA 5DFRA 2XW7A 5HVBA 1JOLA 4HOEA 4FHBA 3DFRA 4NX7A 3EEMA 3IRNA 3JWMA 4P68A 4KJKA 3QYOA 4EIGA 3DRCA 4H97A 4KM2A 5HUIA 3F0BX 3FRAX 3SGYA 3IX9A 4P3QA 3FY9X 3NZAX 5HSUA 1DYJA 4Q0EA 4KJLA 1DR2A 3SRSX 3SAIA 4Q6AA 3L3RA 3DL5A 4G3MA 4I13A 1DR5A 3E0BA 2W3BA 4KEBA 3GHVA 3QLZA 4KY8A 4KNEA 3QL0A 3QYLA 4G8ZX 2OBCA 3SRRX 4XE6X 3SH2A 1RB2A 4PSTA 3ZPCA 3CSEA 3OAFA 4QLGA 4M7VA 3IROA 7DFRA 3FRDX 1U70A 1HFQA 3R33A 1HFRA 2JYBA 4PSSA 1KMSA 3TD8A 4DPDA 5HF0X 4HA9A 3FREX 4QI9A 1OHJA 1YHOA 5JG0X 3JW3A 1RE7A 1RX9A 3QL3A 3RO9A 1DRBA 4ELGA 2FZHA 3EEJA 3IA5A 3K2HA 2O7PA 3FQZA 4KFJA 3JSUA 4RGCA 4KL9A 5HT5A 3F8ZA 3HBBA 3KY8A 1RX7A 1RA1A 3QLSA 3SA1A 1RA2A 5HI6A 4M6LA 4PSYA 2C2TA 3F8YA 2LF1A 3NXRA 1RX3A 2CD2A 3SRWX 1DR1A 4M6KA 4DP3A 3JWCA 5JA3A 1RH3A 1TDRA 4OSGA 3NXXA 2D5NA 1DHFA 1PD8A 3EX8A 3ROAA 5FDAA 3SQYX 3QLYA 4EILA 3FYVX 3IA4A 1J3KA 2FZIA 3NZDA 1RC4A 3S7AA 1DR6A 3EELA 1M7AA 1CZ3A 5U27A 3DAUA 3QGTA 4H96A 2ZZAA 4TU5X 3D80A 1M79A 3KJSA 4QLEA 1LY3A 3EEKA 4LEKX 1RA8A 2KGKA 5HQZA 1MVSA 1DAJA 5CCCA 2BLAA 3SRUX 3F0QX 3QFXA 3GHWA 1RX5A 2AZNA 1S3VA 1DG7A 1DLSA 1DRFA 1E26A 4H95A 2ITHA 1RF7A 4Q67A 4HOGA 1DIUA 2HQPA 4PTHA 4ELHA 3NZ9X 3NZCX 1AI9A 3CLBA 4IXED 2BL9A 3D84X 4CD2A 1AOEA 3K74A 4KJJA 3FQCA 4ELEA 4FGHA 2FZJA 2W3VA 2W3WA 2HM9A 3SRQX 2ANOA 1IA3A 1U71A 3JVXA 1DDRA 4P3RA 5HPBA 3IRMA 1HFPA 4IXFX 4NX6A 2DRCA 2ANQA 5ECCA 1RA3A 1ZDRA 2W9SA 2L28A 4LAEX 3M09A 3QG2A 1S3WA 4KD7A 1DREA 4XT4A 1DHJA 3LG4A 1DRAA 1DYHA 3TQ8A 4FGGA 3KGYA 1DR4A 3KJRA 1RG7A 3NZ6X 2C2SA 3NXOA 2QK8A 3NU0A 4QLFA 5EAJA 4G95A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3FL8 A;  4KBN A;  1J3I A;  4DDR A;  4P66 A;  1QZF A;  4I1N A;  4OR7 A;  4KM0 A;  3I8A X;  3F0X X;  3K45 A;  4DFR A;  4X5F A;  4HA7 A;  3QLX A;  1VDR A;  3CD2 A;  1J3J A;  3JTW A;  4QHV A;  4M2X A;  2D0K A;  1LUD A;  1SEJ A;  2P4G A;  4ECK A;  2OIP A;  4IXG X;  3NTZ A;  5U26 A;  1PD9 A;  4M7U A;  1RD7 A;  3FQO A;  3JW5 A;  3NZB X;  4KLX A;  4XT7 A;  1DF7 A;  3OCH A;  1DHI A;  3NXV A;  1DR7 A;  3S3V A;  3FL9 A;  5HVE A;  3NXY A;  3DGA A;  4EJ1 A;  3S9U A;  1AO8 A;  3SA2 A;  3NXT A;  1DLR A;  5HT4 A;  3QLR A;  3K47 A;  1RX6 A;  3DL6 A;  3QLW A;  1BOZ A;  4KY4 A;  4X5G A;  5CC9 A;  1M78 A;  5HF2 X;  1DG8 A;  4XRB A;  1RX4 A;  1MVT A;  3JWF A;  3UM8 A;  2BLB A;  1KMV A;  1RA9 A;  3ZPG A;  3F0V X;  4XT5 A;  1PDB A;  2H2Q A;  4HOF A;  1DDS A;  3RG9 A;  1DR3 A;  1S3U A;  4PTJ A;  3TQB A;  1OHK A;  4XT8 A;  1JUV A;  3FQF A;  4LAG X;  1D1G A;  5ECX A;  3DAT A;  3F0U X;  3FRB X;  4X5I A;  2GD9 A;  4QJZ D;  3JWK A;  5E8Q A;  8DFR A;  4ELF A;  4KAK A;  3UM5 A;  1LY4 A;  3NRR A;  3FYW X;  2W9H A;  3F91 A;  3EIG A;  2G6V A;  2CIG A;  3DG8 A;  4KYA A;  4DPH A;  1CD2 A;  5DXV A;  2INQ A;  1DG5 A;  3FY8 X;  3KFY A;  6DFR A;  2DHF A;  3INV A;  4LAH X;  3UM6 A;  4GH8 A;  1U72 A;  1DYR A;  1S3Y A;  1DIS A;  1DRH A;  4M6J A;  1RX2 A;  1IA4 A;  4ELB A;  3TQ9 A;  4PDJ A;  2B3Z A;  3VCO A;  3HJ3 A;  3GHC A;  5HQY A;  4XEC X;  4X5J A;  3GI2 A;  4XT6 A;  4H98 A;  2HXV A;  3I3R A;  3FRF X;  1RB3 A;  1BZF A;  4QJC A;  3FS6 A;  3SR5 X;  4X5H A;  3FQ0 A;  2BLC A;  1RX8 A;  2W9T A;  1IA1 A;  2W9G A;  3FQV A;  3TQA A;  3CL9 A;  1KLK A;  3F0S X;  3M08 A;  3Q1H A;  3N0H A;  3GYF A;  1RX1 A;  1JOM A;  5HSR A;  1IA2 A;  1DYI A;  4EIZ A;  1VJ3 A;  2W3M A;  4Q0D A;  2W3A A;  5DFR A;  2XW7 A;  5HVB A;  1JOL A;  4HOE A;  4FHB A;  3DFR A;  4NX7 A;  3EEM A;  3IRN A;  3JWM A;  4P68 A;  4KJK A;  3QYO A;  4EIG A;  3DRC A;  4H97 A;  4KM2 A;  5HUI A;  3F0B X;  3FRA X;  3SGY A;  3IX9 A;  4P3Q A;  3FY9 X;  3NZA X;  5HSU A;  1DYJ A;  4Q0E A;  4KJL A;  1DR2 A;  3SRS X;  3SAI A;  4Q6A A;  3L3R A;  3DL5 A;  4G3M A;  4I13 A;  1DR5 A;  3E0B A;  2W3B A;  4KEB A;  3GHV A;  3QLZ A;  4KY8 A;  4KNE A;  3QL0 A;  3QYL A;  4G8Z X;  2OBC A;  3SRR X;  4XE6 X;  3SH2 A;  1RB2 A;  4PST A;  3ZPC A;  3CSE A;  3OAF A;  4QLG A;  4M7V A;  3IRO A;  7DFR A;  3FRD X;  1U70 A;  1HFQ A;  3R33 A;  1HFR A;  2JYB A;  4PSS A;  1KMS A;  3TD8 A;  4DPD A;  5HF0 X;  4HA9 A;  3FRE X;  4QI9 A;  1OHJ A;  1YHO A;  5JG0 X;  3JW3 A;  1RE7 A;  1RX9 A;  3QL3 A;  3RO9 A;  1DRB A;  4ELG A;  2FZH A;  3EEJ A;  3IA5 A;  3K2H A;  2O7P A;  3FQZ A;  4KFJ A;  3JSU A;  4RGC A;  4KL9 A;  5HT5 A;  3F8Z A;  3HBB A;  3KY8 A;  1RX7 A;  1RA1 A;  3QLS A;  3SA1 A;  1RA2 A;  5HI6 A;  4M6L A;  4PSY A;  2C2T A;  3F8Y A;  2LF1 A;  3NXR A;  1RX3 A;  2CD2 A;  3SRW X;  1DR1 A;  4M6K A;  4DP3 A;  3JWC A;  5JA3 A;  1RH3 A;  1TDR A;  4OSG A;  3NXX A;  2D5N A;  1DHF A;  1PD8 A;  3EX8 A;  3ROA A;  5FDA A;  3SQY X;  3QLY A;  4EIL A;  3FYV X;  3IA4 A;  1J3K A;  2FZI A;  3NZD A;  1RC4 A;  3S7A A;  1DR6 A;  3EEL A;  1M7A A;  1CZ3 A;  5U27 A;  3DAU A;  3QGT A;  4H96 A;  2ZZA A;  4TU5 X;  3D80 A;  1M79 A;  3KJS A;  4QLE A;  1LY3 A;  3EEK A;  4LEK X;  1RA8 A;  2KGK A;  5HQZ A;  1MVS A;  1DAJ A;  5CCC A;  2BLA A;  3SRU X;  3F0Q X;  3QFX A;  3GHW A;  1RX5 A;  2AZN A;  1S3V A;  1DG7 A;  1DLS A;  1DRF A;  1E26 A;  4H95 A;  2ITH A;  1RF7 A;  4Q67 A;  4HOG A;  1DIU A;  2HQP A;  4PTH A;  4ELH A;  3NZ9 X;  3NZC X;  1AI9 A;  3CLB A;  4IXE D;  2BL9 A;  3D84 X;  4CD2 A;  1AOE A;  3K74 A;  4KJJ A;  3FQC A;  4ELE A;  4FGH A;  2FZJ A;  2W3V A;  2W3W A;  2HM9 A;  3SRQ X;  2ANO A;  1IA3 A;  1U71 A;  3JVX A;  1DDR A;  4P3R A;  5HPB A;  3IRM A;  1HFP A;  4IXF X;  4NX6 A;  2DRC A;  2ANQ A;  5ECC A;  1RA3 A;  1ZDR A;  2W9S A;  2L28 A;  4LAE X;  3M09 A;  3QG2 A;  1S3W A;  4KD7 A;  1DRE A;  4XT4 A;  1DHJ A;  3LG4 A;  1DRA A;  1DYH A;  3TQ8 A;  4FGG A;  3KGY A;  1DR4 A;  3KJR A;  1RG7 A;  3NZ6 X;  2C2S A;  3NXO A;  2QK8 A;  3NU0 A;  4QLF A;  5EAJ A;  4G95 A; 
#chains in the Genus database with same CATH topology
 3FL8 A;  4KBN A;  1J3I A;  4DDR A;  4P66 A;  1QZF A;  4I1N A;  4OR7 A;  4KM0 A;  3I8A X;  3F0X X;  3K45 A;  4DFR A;  4X5F A;  4HA7 A;  3QLX A;  1VDR A;  3CD2 A;  1J3J A;  3JTW A;  4QHV A;  4M2X A;  2D0K A;  1LUD A;  1SEJ A;  2P4G A;  4ECK A;  2OIP A;  4IXG X;  3NTZ A;  5U26 A;  1PD9 A;  4M7U A;  1RD7 A;  3FQO A;  3JW5 A;  3NZB X;  4KLX A;  4XT7 A;  1DF7 A;  3OCH A;  1DHI A;  3NXV A;  1DR7 A;  3S3V A;  3FL9 A;  5HVE A;  3NXY A;  3DGA A;  4EJ1 A;  3S9U A;  1AO8 A;  3SA2 A;  3NXT A;  1DLR A;  5HT4 A;  3QLR A;  3K47 A;  1RX6 A;  3DL6 A;  3QLW A;  1BOZ A;  4KY4 A;  4X5G A;  5CC9 A;  1M78 A;  5HF2 X;  1DG8 A;  4XRB A;  1RX4 A;  1MVT A;  3JWF A;  3UM8 A;  2BLB A;  1KMV A;  1RA9 A;  3ZPG A;  3F0V X;  4XT5 A;  1PDB A;  2H2Q A;  4HOF A;  1DDS A;  3RG9 A;  1DR3 A;  1S3U A;  4PTJ A;  3TQB A;  1OHK A;  4XT8 A;  1JUV A;  3FQF A;  4LAG X;  1D1G A;  5ECX A;  3DAT A;  3F0U X;  3FRB X;  4X5I A;  2GD9 A;  4QJZ D;  3JWK A;  5E8Q A;  8DFR A;  4ELF A;  4KAK A;  3UM5 A;  1LY4 A;  3NRR A;  3FYW X;  2W9H A;  3F91 A;  3EIG A;  2G6V A;  2CIG A;  3DG8 A;  4KYA A;  4DPH A;  1CD2 A;  5DXV A;  2INQ A;  1DG5 A;  3FY8 X;  3KFY A;  6DFR A;  2DHF A;  3INV A;  4LAH X;  3UM6 A;  4GH8 A;  1U72 A;  1DYR A;  1S3Y A;  1DIS A;  1DRH A;  4M6J A;  1RX2 A;  1IA4 A;  4ELB A;  3TQ9 A;  4PDJ A;  2B3Z A;  3VCO A;  3HJ3 A;  3GHC A;  5HQY A;  4XEC X;  4X5J A;  3GI2 A;  4XT6 A;  4H98 A;  2HXV A;  3I3R A;  3FRF X;  1RB3 A;  1BZF A;  4QJC A;  3FS6 A;  3SR5 X;  4X5H A;  3FQ0 A;  2BLC A;  1RX8 A;  2W9T A;  1IA1 A;  2W9G A;  3FQV A;  3TQA A;  3CL9 A;  1KLK A;  3F0S X;  3M08 A;  3Q1H A;  3N0H A;  3GYF A;  1RX1 A;  1JOM A;  5HSR A;  1IA2 A;  1DYI A;  4EIZ A;  1VJ3 A;  2W3M A;  4Q0D A;  2W3A A;  5DFR A;  2XW7 A;  5HVB A;  1JOL A;  4HOE A;  4FHB A;  3DFR A;  4NX7 A;  3EEM A;  3IRN A;  3JWM A;  4P68 A;  4KJK A;  3QYO A;  4EIG A;  3DRC A;  4H97 A;  4KM2 A;  5HUI A;  3F0B X;  3FRA X;  3SGY A;  3IX9 A;  4P3Q A;  3FY9 X;  3NZA X;  5HSU A;  1DYJ A;  4Q0E A;  4KJL A;  1DR2 A;  3SRS X;  3SAI A;  4Q6A A;  3L3R A;  3DL5 A;  4G3M A;  4I13 A;  1DR5 A;  3E0B A;  2W3B A;  4KEB A;  3GHV A;  3QLZ A;  4KY8 A;  4KNE A;  3QL0 A;  3QYL A;  4G8Z X;  2OBC A;  3SRR X;  4XE6 X;  3SH2 A;  1RB2 A;  4PST A;  3ZPC A;  3CSE A;  3OAF A;  4QLG A;  4M7V A;  3IRO A;  7DFR A;  3FRD X;  1U70 A;  1HFQ A;  3R33 A;  1HFR A;  2JYB A;  4PSS A;  1KMS A;  3TD8 A;  4DPD A;  5HF0 X;  4HA9 A;  3FRE X;  4QI9 A;  1OHJ A;  1YHO A;  5JG0 X;  3JW3 A;  1RE7 A;  1RX9 A;  3QL3 A;  3RO9 A;  1DRB A;  4ELG A;  2FZH A;  3EEJ A;  3IA5 A;  3K2H A;  2O7P A;  3FQZ A;  4KFJ A;  3JSU A;  4RGC A;  4KL9 A;  5HT5 A;  3F8Z A;  3HBB A;  3KY8 A;  1RX7 A;  1RA1 A;  3QLS A;  3SA1 A;  1RA2 A;  5HI6 A;  4M6L A;  4PSY A;  2C2T A;  3F8Y A;  2LF1 A;  3NXR A;  1RX3 A;  2CD2 A;  3SRW X;  1DR1 A;  4M6K A;  4DP3 A;  3JWC A;  5JA3 A;  1RH3 A;  1TDR A;  4OSG A;  3NXX A;  2D5N A;  1DHF A;  1PD8 A;  3EX8 A;  3ROA A;  5FDA A;  3SQY X;  3QLY A;  4EIL A;  3FYV X;  3IA4 A;  1J3K A;  2FZI A;  3NZD A;  1RC4 A;  3S7A A;  1DR6 A;  3EEL A;  1M7A A;  1CZ3 A;  5U27 A;  3DAU A;  3QGT A;  4H96 A;  2ZZA A;  4TU5 X;  3D80 A;  1M79 A;  3KJS A;  4QLE A;  1LY3 A;  3EEK A;  4LEK X;  1RA8 A;  2KGK A;  5HQZ A;  1MVS A;  1DAJ A;  5CCC A;  2BLA A;  3SRU X;  3F0Q X;  3QFX A;  3GHW A;  1RX5 A;  2AZN A;  1S3V A;  1DG7 A;  1DLS A;  1DRF A;  1E26 A;  4H95 A;  2ITH A;  1RF7 A;  4Q67 A;  4HOG A;  1DIU A;  2HQP A;  4PTH A;  4ELH A;  3NZ9 X;  3NZC X;  1AI9 A;  3CLB A;  4IXE D;  2BL9 A;  3D84 X;  4CD2 A;  1AOE A;  3K74 A;  4KJJ A;  3FQC A;  4ELE A;  4FGH A;  2FZJ A;  2W3V A;  2W3W A;  2HM9 A;  3SRQ X;  2ANO A;  1IA3 A;  1U71 A;  3JVX A;  1DDR A;  4P3R A;  5HPB A;  3IRM A;  1HFP A;  4IXF X;  4NX6 A;  2DRC A;  2ANQ A;  5ECC A;  1RA3 A;  1ZDR A;  2W9S A;  2L28 A;  4LAE X;  3M09 A;  3QG2 A;  1S3W A;  4KD7 A;  1DRE A;  4XT4 A;  1DHJ A;  3LG4 A;  1DRA A;  1DYH A;  3TQ8 A;  4FGG A;  3KGY A;  1DR4 A;  3KJR A;  1RG7 A;  3NZ6 X;  2C2S A;  3NXO A;  2QK8 A;  3NU0 A;  4QLF A;  5EAJ A;  4G95 A; 
#chains in the Genus database with same CATH homology
 3FL8 A;  4KBN A;  1J3I A;  4DDR A;  4P66 A;  1QZF A;  4I1N A;  4OR7 A;  4KM0 A;  3I8A X;  3F0X X;  3K45 A;  4DFR A;  4X5F A;  4HA7 A;  3QLX A;  1VDR A;  3CD2 A;  1J3J A;  3JTW A;  4QHV A;  4M2X A;  2D0K A;  1LUD A;  1SEJ A;  2P4G A;  4ECK A;  2OIP A;  4IXG X;  3NTZ A;  5U26 A;  1PD9 A;  4M7U A;  1RD7 A;  3FQO A;  3JW5 A;  3NZB X;  4KLX A;  4XT7 A;  1DF7 A;  3OCH A;  1DHI A;  3NXV A;  1DR7 A;  3S3V A;  3FL9 A;  5HVE A;  3NXY A;  3DGA A;  4EJ1 A;  3S9U A;  1AO8 A;  3SA2 A;  3NXT A;  1DLR A;  5HT4 A;  3QLR A;  3K47 A;  1RX6 A;  3DL6 A;  3QLW A;  1BOZ A;  4KY4 A;  4X5G A;  5CC9 A;  1M78 A;  5HF2 X;  1DG8 A;  4XRB A;  1RX4 A;  1MVT A;  3JWF A;  3UM8 A;  2BLB A;  1KMV A;  1RA9 A;  3ZPG A;  3F0V X;  4XT5 A;  1PDB A;  2H2Q A;  4HOF A;  1DDS A;  3RG9 A;  1DR3 A;  1S3U A;  4PTJ A;  3TQB A;  1OHK A;  4XT8 A;  1JUV A;  3FQF A;  4LAG X;  1D1G A;  5ECX A;  3DAT A;  3F0U X;  3FRB X;  4X5I A;  2GD9 A;  4QJZ D;  3JWK A;  5E8Q A;  8DFR A;  4ELF A;  4KAK A;  3UM5 A;  1LY4 A;  3NRR A;  3FYW X;  2W9H A;  3F91 A;  3EIG A;  2G6V A;  2CIG A;  3DG8 A;  4KYA A;  4DPH A;  1CD2 A;  5DXV A;  2INQ A;  1DG5 A;  3FY8 X;  3KFY A;  6DFR A;  2DHF A;  3INV A;  4LAH X;  3UM6 A;  4GH8 A;  1U72 A;  1DYR A;  1S3Y A;  1DIS A;  1DRH A;  4M6J A;  1RX2 A;  1IA4 A;  4ELB A;  3TQ9 A;  4PDJ A;  2B3Z A;  3VCO A;  3HJ3 A;  3GHC A;  5HQY A;  4XEC X;  4X5J A;  3GI2 A;  4XT6 A;  4H98 A;  2HXV A;  3I3R A;  3FRF X;  1RB3 A;  1BZF A;  4QJC A;  3FS6 A;  3SR5 X;  4X5H A;  3FQ0 A;  2BLC A;  1RX8 A;  2W9T A;  1IA1 A;  2W9G A;  3FQV A;  3TQA A;  3CL9 A;  1KLK A;  3F0S X;  3M08 A;  3Q1H A;  3N0H A;  3GYF A;  1RX1 A;  1JOM A;  5HSR A;  1IA2 A;  1DYI A;  4EIZ A;  1VJ3 A;  2W3M A;  4Q0D A;  2W3A A;  5DFR A;  2XW7 A;  5HVB A;  1JOL A;  4HOE A;  4FHB A;  3DFR A;  4NX7 A;  3EEM A;  3IRN A;  3JWM A;  4P68 A;  4KJK A;  3QYO A;  4EIG A;  3DRC A;  4H97 A;  4KM2 A;  5HUI A;  3F0B X;  3FRA X;  3SGY A;  3IX9 A;  4P3Q A;  3FY9 X;  3NZA X;  5HSU A;  1DYJ A;  4Q0E A;  4KJL A;  1DR2 A;  3SRS X;  3SAI A;  4Q6A A;  3L3R A;  3DL5 A;  4G3M A;  4I13 A;  1DR5 A;  3E0B A;  2W3B A;  4KEB A;  3GHV A;  3QLZ A;  4KY8 A;  4KNE A;  3QL0 A;  3QYL A;  4G8Z X;  2OBC A;  3SRR X;  4XE6 X;  3SH2 A;  1RB2 A;  4PST A;  3ZPC A;  3CSE A;  3OAF A;  4QLG A;  4M7V A;  3IRO A;  7DFR A;  3FRD X;  1U70 A;  1HFQ A;  3R33 A;  1HFR A;  2JYB A;  4PSS A;  1KMS A;  3TD8 A;  4DPD A;  5HF0 X;  4HA9 A;  3FRE X;  4QI9 A;  1OHJ A;  1YHO A;  5JG0 X;  3JW3 A;  1RE7 A;  1RX9 A;  3QL3 A;  3RO9 A;  1DRB A;  4ELG A;  2FZH A;  3EEJ A;  3IA5 A;  3K2H A;  2O7P A;  3FQZ A;  4KFJ A;  3JSU A;  4RGC A;  4KL9 A;  5HT5 A;  3F8Z A;  3HBB A;  3KY8 A;  1RX7 A;  1RA1 A;  3QLS A;  3SA1 A;  1RA2 A;  5HI6 A;  4M6L A;  4PSY A;  2C2T A;  3F8Y A;  2LF1 A;  3NXR A;  1RX3 A;  2CD2 A;  3SRW X;  1DR1 A;  4M6K A;  4DP3 A;  3JWC A;  5JA3 A;  1RH3 A;  1TDR A;  4OSG A;  3NXX A;  2D5N A;  1DHF A;  1PD8 A;  3EX8 A;  3ROA A;  5FDA A;  3SQY X;  3QLY A;  4EIL A;  3FYV X;  3IA4 A;  1J3K A;  2FZI A;  3NZD A;  1RC4 A;  3S7A A;  1DR6 A;  3EEL A;  1M7A A;  1CZ3 A;  5U27 A;  3DAU A;  3QGT A;  4H96 A;  2ZZA A;  4TU5 X;  3D80 A;  1M79 A;  3KJS A;  4QLE A;  1LY3 A;  3EEK A;  4LEK X;  1RA8 A;  2KGK A;  5HQZ A;  1MVS A;  1DAJ A;  5CCC A;  2BLA A;  3SRU X;  3F0Q X;  3QFX A;  3GHW A;  1RX5 A;  2AZN A;  1S3V A;  1DG7 A;  1DLS A;  1DRF A;  1E26 A;  4H95 A;  2ITH A;  1RF7 A;  4Q67 A;  4HOG A;  1DIU A;  2HQP A;  4PTH A;  4ELH A;  3NZ9 X;  3NZC X;  1AI9 A;  3CLB A;  4IXE D;  2BL9 A;  3D84 X;  4CD2 A;  1AOE A;  3K74 A;  4KJJ A;  3FQC A;  4ELE A;  4FGH A;  2FZJ A;  2W3V A;  2W3W A;  2HM9 A;  3SRQ X;  2ANO A;  1IA3 A;  1U71 A;  3JVX A;  1DDR A;  4P3R A;  5HPB A;  3IRM A;  1HFP A;  4IXF X;  4NX6 A;  2DRC A;  2ANQ A;  5ECC A;  1RA3 A;  1ZDR A;  2W9S A;  2L28 A;  4LAE X;  3M09 A;  3QG2 A;  1S3W A;  4KD7 A;  1DRE A;  4XT4 A;  1DHJ A;  3LG4 A;  1DRA A;  1DYH A;  3TQ8 A;  4FGG A;  3KGY A;  1DR4 A;  3KJR A;  1RG7 A;  3NZ6 X;  2C2S A;  3NXO A;  2QK8 A;  3NU0 A;  4QLF A;  5EAJ A;  4G95 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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