4ELBA

Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
166
structure length
166
Chain Sequence
MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Bacillus anthracis
molecule keywords Dihydrofolate reductase
total genus 40
structure length 166
sequence length 166
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2012-04-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4elbA00
1RA8A 5HVEA 1MVSA 3DATA 1RX3A 3FRFX 3FY8X 1U71A 1DYJA 4H97A 3D84X 4DDRA 4KM2A 1RX6A 2C2TA 4X5HA 1DDRA 4KJLA 1HFRA 1DRAA 4GH8A 4NX7A 5HF0X 1RB3A 3NZAX 1DREA 3SGYA 3NXVA 4EILA 5CCCA 1RX8A 2BLAA 5HSRA 4KY4A 3SA2A 4QJZD 3UM5A 3EELA 1S3UA 3LG4A 4QHVA 2AZNA 4HOEA 5JA3A 3M08A 4H95A 5DXVA 3OCHA 3IA5A 2OIPA 3IRMA 1DHFA 5HPBA 4KNEA 1PD8A 2HXVA 1DYIA 1DYRA 1VDRA 4KFJA 1RF7A 4OR7A 1RA9A 4QJCA 3SRSX 3JWMA 4PDJA 5FDAA 3K45A 1AO8A 4HOGA 8DFRA 3F8YA 3NXRA 3TD8A 4X5IA 3DFRA 4M6KA 3ZPGA 3GHVA 1RA3A 3RG9A 6DFRA 2OBCA 4QLEA 2DHFA 1M78A 3GHWA 2C2SA 5CC9A 3FRAX 2W3BA 3QLZA 1TDRA 4M7VA 5DFRA 3F0QX 3HBBA 1DG8A 4KYAA 4G95A 4FGHA 3F91A 1HFPA 3NU0A 1RC4A 3QLSA 4Q67A 3JSUA 3EEKA 5HT4A 3QL0A 1J3KA 2O7PA 3DAUA 1ZDRA 3FL8A 3KFYA 4DPHA 4HOFA 4XT7A 3K74A 3DG8A 2BLBA 3NZBX 5HUIA 4LAGX 1M79A 2ANOA 1RX9A 3NRRA 2FZHA 1VJ3A 5HQZA 7DFRA 4KBNA 4ELBA 4XECX 1AOEA 3NZDA 1E26A 4DPDA 4IXED 1DG5A 3JVXA 5U26A 1DHJA 3SRUX 3SH2A 3SA1A 1DLRA 2ZZAA 3R33A 2W3VA 4NX6A 1SEJA 4PSTA 1PDBA 3EX8A 2INQA 3FQOA 2CIGA 4M7UA 3Q1HA 1RX2A 2D5NA 3F0SX 1DYHA 4ECKA 3F0UX 4XRBA 4QLGA 3QFXA 1BOZA 4FHBA 4IXGX 2G6VA 3DRCA 1IA2A 3FQCA 1D1GA 4EIGA 1DR7A 1JOLA 3CLBA 3FREX 2DRCA 5U27A 3QL3A 1J3IA 3GYFA 3F8ZA 4H96A 3S3VA 1LY4A 4CD2A 4HA7A 3SR5X 3TQ9A 2FZIA 4I1NA 2HM9A 4XT5A 1JOMA 2BL9A 2B3ZA 3F0BX 1LUDA 1DRFA 1S3WA 3QLRA 1S3VA 4KD7A 4X5FA 3TQ8A 3NXOA 3TQBA 2H2QA 3HJ3A 3FS6A 3K47A 1YHOA 2KGKA 3FYWX 3QGTA 5HQYA 3DL6A 5HSUA 1DR2A 3RO9A 4KL9A 4ELGA 3QLXA 3JWFA 3VCOA 1DR4A 3NXYA 3KJSA 3DL5A 4KEBA 1IA3A 3I3RA 2W9SA 4QLFA 3TQAA 2XW7A 2ITHA 3QLWA 4XE6X 3FQZA 4P3QA 1DISA 5HVBA 4X5GA 4TU5X 4PTHA 1RX5A 3QYLA 3KJRA 1IA4A 3SRQX 3ZPCA 3M09A 4KAKA 1MVTA 3UM8A 3I8AX 2BLCA 4KLXA 3NZ6X 3ROAA 3FY9X 4PTJA 1RD7A 3L3RA 4M6LA 2W9GA 2W3MA 1OHKA 1DG7A 2HQPA 3OAFA 5HI6A 1S3YA 2W3AA 3D80A 4OSGA 3NZCX 1BZFA 3FQFA 3FRDX 1RX7A 3CL9A 1KMSA 4DFRA 3SAIA 1RX1A 4M6JA 4PSYA 1QZFA 4G8ZX 4Q0DA 4FGGA 3N0HA 1AI9A 1IA1A 2LF1A 4P68A 1LY3A 3FYVX 4ELEA 1DIUA 3JWCA 3EEMA 1HFQA 3FRBX 1RE7A 4IXFX 3NXXA 2GD9A 3IA4A 3E0BA 2W9HA 1JUVA 5ECCA 2P4GA 4KM0A 4XT4A 3UM6A 1KLKA 1DRBA 3GHCA 5E8QA 3IROA 4Q6AA 1OHJA 2W9TA 3NXTA 4HA9A 3F0VX 1DR5A 3IRNA 3CSEA 1RB2A 2JYBA 4KJKA 2CD2A 3FQ0A 3JWKA 2L28A 1DRHA 4Q0EA 1DAJA 3JW5A 5HF2X 1DR3A 2D0KA 3QG2A 3JW3A 1RG7A 4LAHX 3DGAA 5JG0X 3EIGA 3F0XX 3KY8A 1CD2A 1DLSA 4DP3A 2QK8A 4I13A 3FQVA 3JTWA 4QI9A 1DF7A 4H98A 4EJ1A 1RH3A 3S7AA 4ELHA 1RX4A 1DDSA 1CZ3A 3NZ9X 3SQYX 3SRRX 4KY8A 3KGYA 3QYOA 4X5JA 3CD2A 4ELFA 4XT6A 3FL9A 3IX9A 4PSSA 1M7AA 1U72A 1RA2A 4KJJA 1U70A 1RA1A 4LEKX 4RGCA 1PD9A 4P66A 3INVA 2ANQA 4M2XA 5ECXA 4G3MA 3EEJA 3K2HA 5HT5A 1DR6A 2W3WA 4P3RA 3QLYA 4LAEX 2FZJA 4EIZA 1KMVA 4XT8A 1DHIA 3GI2A 5EAJA 1J3JA 3SRWX 3NTZA 3S9UA 1DR1A
chains in the Genus database with same CATH superfamily
1RA8A 5HVEA 1MVSA 3DATA 1RX3A 3FRFX 3FY8X 1U71A 1DYJA 4H97A 3D84X 4DDRA 4KM2A 1RX6A 2C2TA 4X5HA 1DDRA 4KJLA 1HFRA 1DRAA 4GH8A 4NX7A 5HF0X 1RB3A 3NZAX 1DREA 3SGYA 3NXVA 4EILA 5CCCA 1RX8A 2BLAA 5HSRA 4KY4A 3SA2A 4QJZD 3UM5A 3EELA 1S3UA 3LG4A 4QHVA 2AZNA 4HOEA 5JA3A 3M08A 4H95A 5DXVA 3OCHA 3IA5A 2OIPA 3IRMA 1DHFA 5HPBA 4KNEA 1PD8A 2HXVA 1DYIA 1DYRA 1VDRA 4KFJA 1RF7A 4OR7A 1RA9A 4QJCA 3SRSX 3JWMA 4PDJA 5FDAA 3K45A 1AO8A 4HOGA 8DFRA 3F8YA 3NXRA 3TD8A 4X5IA 3DFRA 4M6KA 3ZPGA 3GHVA 1RA3A 3RG9A 6DFRA 2OBCA 4QLEA 2DHFA 1M78A 3GHWA 2C2SA 5CC9A 3FRAX 2W3BA 3QLZA 1TDRA 4M7VA 5DFRA 3F0QX 3HBBA 1DG8A 4KYAA 4G95A 4FGHA 3F91A 1HFPA 3NU0A 1RC4A 3QLSA 4Q67A 3JSUA 3EEKA 5HT4A 3QL0A 1J3KA 2O7PA 3DAUA 1ZDRA 3FL8A 3KFYA 4DPHA 4HOFA 4XT7A 3K74A 3DG8A 2BLBA 3NZBX 5HUIA 4LAGX 1M79A 2ANOA 1RX9A 3NRRA 2FZHA 1VJ3A 5HQZA 7DFRA 4KBNA 4ELBA 4XECX 1AOEA 3NZDA 1E26A 4DPDA 4IXED 1DG5A 3JVXA 5U26A 1DHJA 3SRUX 3SH2A 3SA1A 1DLRA 2ZZAA 3R33A 2W3VA 4NX6A 1SEJA 4PSTA 1PDBA 3EX8A 2INQA 3FQOA 2CIGA 4M7UA 3Q1HA 1RX2A 2D5NA 3F0SX 1DYHA 4ECKA 3F0UX 4XRBA 4QLGA 3QFXA 1BOZA 4FHBA 4IXGX 2G6VA 3DRCA 1IA2A 3FQCA 1D1GA 4EIGA 1DR7A 1JOLA 3CLBA 3FREX 2DRCA 5U27A 3QL3A 1J3IA 3GYFA 3F8ZA 4H96A 3S3VA 1LY4A 4CD2A 4HA7A 3SR5X 3TQ9A 2FZIA 4I1NA 2HM9A 4XT5A 1JOMA 2BL9A 2B3ZA 3F0BX 1LUDA 1DRFA 1S3WA 3QLRA 1S3VA 4KD7A 4X5FA 3TQ8A 3NXOA 3TQBA 2H2QA 3HJ3A 3FS6A 3K47A 1YHOA 2KGKA 3FYWX 3QGTA 5HQYA 3DL6A 5HSUA 1DR2A 3RO9A 4KL9A 4ELGA 3QLXA 3JWFA 3VCOA 1DR4A 3NXYA 3KJSA 3DL5A 4KEBA 1IA3A 3I3RA 2W9SA 4QLFA 3TQAA 2XW7A 2ITHA 3QLWA 4XE6X 3FQZA 4P3QA 1DISA 5HVBA 4X5GA 4TU5X 4PTHA 1RX5A 3QYLA 3KJRA 1IA4A 3SRQX 3ZPCA 3M09A 4KAKA 1MVTA 3UM8A 3I8AX 2BLCA 4KLXA 3NZ6X 3ROAA 3FY9X 4PTJA 1RD7A 3L3RA 4M6LA 2W9GA 2W3MA 1OHKA 1DG7A 2HQPA 3OAFA 5HI6A 1S3YA 2W3AA 3D80A 4OSGA 3NZCX 1BZFA 3FQFA 3FRDX 1RX7A 3CL9A 1KMSA 4DFRA 3SAIA 1RX1A 4M6JA 4PSYA 1QZFA 4G8ZX 4Q0DA 4FGGA 3N0HA 1AI9A 1IA1A 2LF1A 4P68A 1LY3A 3FYVX 4ELEA 1DIUA 3JWCA 3EEMA 1HFQA 3FRBX 1RE7A 4IXFX 3NXXA 2GD9A 3IA4A 3E0BA 2W9HA 1JUVA 5ECCA 2P4GA 4KM0A 4XT4A 3UM6A 1KLKA 1DRBA 3GHCA 5E8QA 3IROA 4Q6AA 1OHJA 2W9TA 3NXTA 4HA9A 3F0VX 1DR5A 3IRNA 3CSEA 1RB2A 2JYBA 4KJKA 2CD2A 3FQ0A 3JWKA 2L28A 1DRHA 4Q0EA 1DAJA 3JW5A 5HF2X 1DR3A 2D0KA 3QG2A 3JW3A 1RG7A 4LAHX 3DGAA 5JG0X 3EIGA 3F0XX 3KY8A 1CD2A 1DLSA 4DP3A 2QK8A 4I13A 3FQVA 3JTWA 4QI9A 1DF7A 4H98A 4EJ1A 1RH3A 3S7AA 4ELHA 1RX4A 1DDSA 1CZ3A 3NZ9X 3SQYX 3SRRX 4KY8A 3KGYA 3QYOA 4X5JA 3CD2A 4ELFA 4XT6A 3FL9A 3IX9A 4PSSA 1M7AA 1U72A 1RA2A 4KJJA 1U70A 1RA1A 4LEKX 4RGCA 1PD9A 4P66A 3INVA 2ANQA 4M2XA 5ECXA 4G3MA 3EEJA 3K2HA 5HT5A 1DR6A 2W3WA 4P3RA 3QLYA 4LAEX 2FZJA 4EIZA 1KMVA 4XT8A 1DHIA 3GI2A 5EAJA 1J3JA 3SRWX 3NTZA 3S9UA 1DR1A
chains in the Genus database with same CATH topology
1RA8A 5HVEA 1MVSA 3DATA 1RX3A 3FRFX 3FY8X 1U71A 1DYJA 4H97A 3D84X 4DDRA 4KM2A 1RX6A 2C2TA 4X5HA 1DDRA 4KJLA 1HFRA 1DRAA 4GH8A 4NX7A 5HF0X 1RB3A 3NZAX 1DREA 3SGYA 3NXVA 4EILA 5CCCA 1RX8A 2BLAA 5HSRA 4KY4A 3SA2A 4QJZD 3UM5A 3EELA 1S3UA 3LG4A 4QHVA 2AZNA 4HOEA 5JA3A 3M08A 4H95A 5DXVA 3OCHA 3IA5A 2OIPA 3IRMA 1DHFA 5HPBA 4KNEA 1PD8A 2HXVA 1DYIA 1DYRA 1VDRA 4KFJA 1RF7A 4OR7A 1RA9A 4QJCA 3SRSX 3JWMA 4PDJA 5FDAA 3K45A 1AO8A 4HOGA 8DFRA 3F8YA 3NXRA 3TD8A 4X5IA 3DFRA 4M6KA 3ZPGA 3GHVA 1RA3A 3RG9A 6DFRA 2OBCA 4QLEA 2DHFA 1M78A 3GHWA 2C2SA 5CC9A 3FRAX 2W3BA 3QLZA 1TDRA 4M7VA 5DFRA 3F0QX 3HBBA 1DG8A 4KYAA 4G95A 4FGHA 3F91A 1HFPA 3NU0A 1RC4A 3QLSA 4Q67A 3JSUA 3EEKA 5HT4A 3QL0A 1J3KA 2O7PA 3DAUA 1ZDRA 3FL8A 3KFYA 4DPHA 4HOFA 4XT7A 3K74A 3DG8A 2BLBA 3NZBX 5HUIA 4LAGX 1M79A 2ANOA 1RX9A 3NRRA 2FZHA 1VJ3A 5HQZA 7DFRA 4KBNA 4ELBA 4XECX 1AOEA 3NZDA 1E26A 4DPDA 4IXED 1DG5A 3JVXA 5U26A 1DHJA 3SRUX 3SH2A 3SA1A 1DLRA 2ZZAA 3R33A 2W3VA 4NX6A 1SEJA 4PSTA 1PDBA 3EX8A 2INQA 3FQOA 2CIGA 4M7UA 3Q1HA 1RX2A 2D5NA 3F0SX 1DYHA 4ECKA 3F0UX 4XRBA 4QLGA 3QFXA 1BOZA 4FHBA 4IXGX 2G6VA 3DRCA 1IA2A 3FQCA 1D1GA 4EIGA 1DR7A 1JOLA 3CLBA 3FREX 2DRCA 5U27A 3QL3A 1J3IA 3GYFA 3F8ZA 4H96A 3S3VA 1LY4A 4CD2A 4HA7A 3SR5X 3TQ9A 2FZIA 4I1NA 2HM9A 4XT5A 1JOMA 2BL9A 2B3ZA 3F0BX 1LUDA 1DRFA 1S3WA 3QLRA 1S3VA 4KD7A 4X5FA 3TQ8A 3NXOA 3TQBA 2H2QA 3HJ3A 3FS6A 3K47A 1YHOA 2KGKA 3FYWX 3QGTA 5HQYA 3DL6A 5HSUA 1DR2A 3RO9A 4KL9A 4ELGA 3QLXA 3JWFA 3VCOA 1DR4A 3NXYA 3KJSA 3DL5A 4KEBA 1IA3A 3I3RA 2W9SA 4QLFA 3TQAA 2XW7A 2ITHA 3QLWA 4XE6X 3FQZA 4P3QA 1DISA 5HVBA 4X5GA 4TU5X 4PTHA 1RX5A 3QYLA 3KJRA 1IA4A 3SRQX 3ZPCA 3M09A 4KAKA 1MVTA 3UM8A 3I8AX 2BLCA 4KLXA 3NZ6X 3ROAA 3FY9X 4PTJA 1RD7A 3L3RA 4M6LA 2W9GA 2W3MA 1OHKA 1DG7A 2HQPA 3OAFA 5HI6A 1S3YA 2W3AA 3D80A 4OSGA 3NZCX 1BZFA 3FQFA 3FRDX 1RX7A 3CL9A 1KMSA 4DFRA 3SAIA 1RX1A 4M6JA 4PSYA 1QZFA 4G8ZX 4Q0DA 4FGGA 3N0HA 1AI9A 1IA1A 2LF1A 4P68A 1LY3A 3FYVX 4ELEA 1DIUA 3JWCA 3EEMA 1HFQA 3FRBX 1RE7A 4IXFX 3NXXA 2GD9A 3IA4A 3E0BA 2W9HA 1JUVA 5ECCA 2P4GA 4KM0A 4XT4A 3UM6A 1KLKA 1DRBA 3GHCA 5E8QA 3IROA 4Q6AA 1OHJA 2W9TA 3NXTA 4HA9A 3F0VX 1DR5A 3IRNA 3CSEA 1RB2A 2JYBA 4KJKA 2CD2A 3FQ0A 3JWKA 2L28A 1DRHA 4Q0EA 1DAJA 3JW5A 5HF2X 1DR3A 2D0KA 3QG2A 3JW3A 1RG7A 4LAHX 3DGAA 5JG0X 3EIGA 3F0XX 3KY8A 1CD2A 1DLSA 4DP3A 2QK8A 4I13A 3FQVA 3JTWA 4QI9A 1DF7A 4H98A 4EJ1A 1RH3A 3S7AA 4ELHA 1RX4A 1DDSA 1CZ3A 3NZ9X 3SQYX 3SRRX 4KY8A 3KGYA 3QYOA 4X5JA 3CD2A 4ELFA 4XT6A 3FL9A 3IX9A 4PSSA 1M7AA 1U72A 1RA2A 4KJJA 1U70A 1RA1A 4LEKX 4RGCA 1PD9A 4P66A 3INVA 2ANQA 4M2XA 5ECXA 4G3MA 3EEJA 3K2HA 5HT5A 1DR6A 2W3WA 4P3RA 3QLYA 4LAEX 2FZJA 4EIZA 1KMVA 4XT8A 1DHIA 3GI2A 5EAJA 1J3JA 3SRWX 3NTZA 3S9UA 1DR1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RA8 A;  5HVE A;  1MVS A;  3DAT A;  1RX3 A;  3FRF X;  3FY8 X;  1U71 A;  1DYJ A;  4H97 A;  3D84 X;  4DDR A;  4KM2 A;  1RX6 A;  2C2T A;  4X5H A;  1DDR A;  4KJL A;  1HFR A;  1DRA A;  4GH8 A;  4NX7 A;  5HF0 X;  1RB3 A;  3NZA X;  1DRE A;  3SGY A;  3NXV A;  4EIL A;  5CCC A;  1RX8 A;  2BLA A;  5HSR A;  4KY4 A;  3SA2 A;  4QJZ D;  3UM5 A;  3EEL A;  1S3U A;  3LG4 A;  4QHV A;  2AZN A;  4HOE A;  5JA3 A;  3M08 A;  4H95 A;  5DXV A;  3OCH A;  3IA5 A;  2OIP A;  3IRM A;  1DHF A;  5HPB A;  4KNE A;  1PD8 A;  2HXV A;  1DYI A;  1DYR A;  1VDR A;  4KFJ A;  1RF7 A;  4OR7 A;  1RA9 A;  4QJC A;  3SRS X;  3JWM A;  4PDJ A;  5FDA A;  3K45 A;  1AO8 A;  4HOG A;  8DFR A;  3F8Y A;  3NXR A;  3TD8 A;  4X5I A;  3DFR A;  4M6K A;  3ZPG A;  3GHV A;  1RA3 A;  3RG9 A;  6DFR A;  2OBC A;  4QLE A;  2DHF A;  1M78 A;  3GHW A;  2C2S A;  5CC9 A;  3FRA X;  2W3B A;  3QLZ A;  1TDR A;  4M7V A;  5DFR A;  3F0Q X;  3HBB A;  1DG8 A;  4KYA A;  4G95 A;  4FGH A;  3F91 A;  1HFP A;  3NU0 A;  1RC4 A;  3QLS A;  4Q67 A;  3JSU A;  3EEK A;  5HT4 A;  3QL0 A;  1J3K A;  2O7P A;  3DAU A;  1ZDR A;  3FL8 A;  3KFY A;  4DPH A;  4HOF A;  4XT7 A;  3K74 A;  3DG8 A;  2BLB A;  3NZB X;  5HUI A;  4LAG X;  1M79 A;  2ANO A;  1RX9 A;  3NRR A;  2FZH A;  1VJ3 A;  5HQZ A;  7DFR A;  4KBN A;  4ELB A;  4XEC X;  1AOE A;  3NZD A;  1E26 A;  4DPD A;  4IXE D;  1DG5 A;  3JVX A;  5U26 A;  1DHJ A;  3SRU X;  3SH2 A;  3SA1 A;  1DLR A;  2ZZA A;  3R33 A;  2W3V A;  4NX6 A;  1SEJ A;  4PST A;  1PDB A;  3EX8 A;  2INQ A;  3FQO A;  2CIG A;  4M7U A;  3Q1H A;  1RX2 A;  2D5N A;  3F0S X;  1DYH A;  4ECK A;  3F0U X;  4XRB A;  4QLG A;  3QFX A;  1BOZ A;  4FHB A;  4IXG X;  2G6V A;  3DRC A;  1IA2 A;  3FQC A;  1D1G A;  4EIG A;  1DR7 A;  1JOL A;  3CLB A;  3FRE X;  2DRC A;  5U27 A;  3QL3 A;  1J3I A;  3GYF A;  3F8Z A;  4H96 A;  3S3V A;  1LY4 A;  4CD2 A;  4HA7 A;  3SR5 X;  3TQ9 A;  2FZI A;  4I1N A;  2HM9 A;  4XT5 A;  1JOM A;  2BL9 A;  2B3Z A;  3F0B X;  1LUD A;  1DRF A;  1S3W A;  3QLR A;  1S3V A;  4KD7 A;  4X5F A;  3TQ8 A;  3NXO A;  3TQB A;  2H2Q A;  3HJ3 A;  3FS6 A;  3K47 A;  1YHO A;  2KGK A;  3FYW X;  3QGT A;  5HQY A;  3DL6 A;  5HSU A;  1DR2 A;  3RO9 A;  4KL9 A;  4ELG A;  3QLX A;  3JWF A;  3VCO A;  1DR4 A;  3NXY A;  3KJS A;  3DL5 A;  4KEB A;  1IA3 A;  3I3R A;  2W9S A;  4QLF A;  3TQA A;  2XW7 A;  2ITH A;  3QLW A;  4XE6 X;  3FQZ A;  4P3Q A;  1DIS A;  5HVB A;  4X5G A;  4TU5 X;  4PTH A;  1RX5 A;  3QYL A;  3KJR A;  1IA4 A;  3SRQ X;  3ZPC A;  3M09 A;  4KAK A;  1MVT A;  3UM8 A;  3I8A X;  2BLC A;  4KLX A;  3NZ6 X;  3ROA A;  3FY9 X;  4PTJ A;  1RD7 A;  3L3R A;  4M6L A;  2W9G A;  2W3M A;  1OHK A;  1DG7 A;  2HQP A;  3OAF A;  5HI6 A;  1S3Y A;  2W3A A;  3D80 A;  4OSG A;  3NZC X;  1BZF A;  3FQF A;  3FRD X;  1RX7 A;  3CL9 A;  1KMS A;  4DFR A;  3SAI A;  1RX1 A;  4M6J A;  4PSY A;  1QZF A;  4G8Z X;  4Q0D A;  4FGG A;  3N0H A;  1AI9 A;  1IA1 A;  2LF1 A;  4P68 A;  1LY3 A;  3FYV X;  4ELE A;  1DIU A;  3JWC A;  3EEM A;  1HFQ A;  3FRB X;  1RE7 A;  4IXF X;  3NXX A;  2GD9 A;  3IA4 A;  3E0B A;  2W9H A;  1JUV A;  5ECC A;  2P4G A;  4KM0 A;  4XT4 A;  3UM6 A;  1KLK A;  1DRB A;  3GHC A;  5E8Q A;  3IRO A;  4Q6A A;  1OHJ A;  2W9T A;  3NXT A;  4HA9 A;  3F0V X;  1DR5 A;  3IRN A;  3CSE A;  1RB2 A;  2JYB A;  4KJK A;  2CD2 A;  3FQ0 A;  3JWK A;  2L28 A;  1DRH A;  4Q0E A;  1DAJ A;  3JW5 A;  5HF2 X;  1DR3 A;  2D0K A;  3QG2 A;  3JW3 A;  1RG7 A;  4LAH X;  3DGA A;  5JG0 X;  3EIG A;  3F0X X;  3KY8 A;  1CD2 A;  1DLS A;  4DP3 A;  2QK8 A;  4I13 A;  3FQV A;  3JTW A;  4QI9 A;  1DF7 A;  4H98 A;  4EJ1 A;  1RH3 A;  3S7A A;  4ELH A;  1RX4 A;  1DDS A;  1CZ3 A;  3NZ9 X;  3SQY X;  3SRR X;  4KY8 A;  3KGY A;  3QYO A;  4X5J A;  3CD2 A;  4ELF A;  4XT6 A;  3FL9 A;  3IX9 A;  4PSS A;  1M7A A;  1U72 A;  1RA2 A;  4KJJ A;  1U70 A;  1RA1 A;  4LEK X;  4RGC A;  1PD9 A;  4P66 A;  3INV A;  2ANQ A;  4M2X A;  5ECX A;  4G3M A;  3EEJ A;  3K2H A;  5HT5 A;  1DR6 A;  2W3W A;  4P3R A;  3QLY A;  4LAE X;  2FZJ A;  4EIZ A;  1KMV A;  4XT8 A;  1DHI A;  3GI2 A;  5EAJ A;  1J3J A;  3SRW X;  3NTZ A;  3S9U A;  1DR1 A; 
#chains in the Genus database with same CATH topology
 1RA8 A;  5HVE A;  1MVS A;  3DAT A;  1RX3 A;  3FRF X;  3FY8 X;  1U71 A;  1DYJ A;  4H97 A;  3D84 X;  4DDR A;  4KM2 A;  1RX6 A;  2C2T A;  4X5H A;  1DDR A;  4KJL A;  1HFR A;  1DRA A;  4GH8 A;  4NX7 A;  5HF0 X;  1RB3 A;  3NZA X;  1DRE A;  3SGY A;  3NXV A;  4EIL A;  5CCC A;  1RX8 A;  2BLA A;  5HSR A;  4KY4 A;  3SA2 A;  4QJZ D;  3UM5 A;  3EEL A;  1S3U A;  3LG4 A;  4QHV A;  2AZN A;  4HOE A;  5JA3 A;  3M08 A;  4H95 A;  5DXV A;  3OCH A;  3IA5 A;  2OIP A;  3IRM A;  1DHF A;  5HPB A;  4KNE A;  1PD8 A;  2HXV A;  1DYI A;  1DYR A;  1VDR A;  4KFJ A;  1RF7 A;  4OR7 A;  1RA9 A;  4QJC A;  3SRS X;  3JWM A;  4PDJ A;  5FDA A;  3K45 A;  1AO8 A;  4HOG A;  8DFR A;  3F8Y A;  3NXR A;  3TD8 A;  4X5I A;  3DFR A;  4M6K A;  3ZPG A;  3GHV A;  1RA3 A;  3RG9 A;  6DFR A;  2OBC A;  4QLE A;  2DHF A;  1M78 A;  3GHW A;  2C2S A;  5CC9 A;  3FRA X;  2W3B A;  3QLZ A;  1TDR A;  4M7V A;  5DFR A;  3F0Q X;  3HBB A;  1DG8 A;  4KYA A;  4G95 A;  4FGH A;  3F91 A;  1HFP A;  3NU0 A;  1RC4 A;  3QLS A;  4Q67 A;  3JSU A;  3EEK A;  5HT4 A;  3QL0 A;  1J3K A;  2O7P A;  3DAU A;  1ZDR A;  3FL8 A;  3KFY A;  4DPH A;  4HOF A;  4XT7 A;  3K74 A;  3DG8 A;  2BLB A;  3NZB X;  5HUI A;  4LAG X;  1M79 A;  2ANO A;  1RX9 A;  3NRR A;  2FZH A;  1VJ3 A;  5HQZ A;  7DFR A;  4KBN A;  4ELB A;  4XEC X;  1AOE A;  3NZD A;  1E26 A;  4DPD A;  4IXE D;  1DG5 A;  3JVX A;  5U26 A;  1DHJ A;  3SRU X;  3SH2 A;  3SA1 A;  1DLR A;  2ZZA A;  3R33 A;  2W3V A;  4NX6 A;  1SEJ A;  4PST A;  1PDB A;  3EX8 A;  2INQ A;  3FQO A;  2CIG A;  4M7U A;  3Q1H A;  1RX2 A;  2D5N A;  3F0S X;  1DYH A;  4ECK A;  3F0U X;  4XRB A;  4QLG A;  3QFX A;  1BOZ A;  4FHB A;  4IXG X;  2G6V A;  3DRC A;  1IA2 A;  3FQC A;  1D1G A;  4EIG A;  1DR7 A;  1JOL A;  3CLB A;  3FRE X;  2DRC A;  5U27 A;  3QL3 A;  1J3I A;  3GYF A;  3F8Z A;  4H96 A;  3S3V A;  1LY4 A;  4CD2 A;  4HA7 A;  3SR5 X;  3TQ9 A;  2FZI A;  4I1N A;  2HM9 A;  4XT5 A;  1JOM A;  2BL9 A;  2B3Z A;  3F0B X;  1LUD A;  1DRF A;  1S3W A;  3QLR A;  1S3V A;  4KD7 A;  4X5F A;  3TQ8 A;  3NXO A;  3TQB A;  2H2Q A;  3HJ3 A;  3FS6 A;  3K47 A;  1YHO A;  2KGK A;  3FYW X;  3QGT A;  5HQY A;  3DL6 A;  5HSU A;  1DR2 A;  3RO9 A;  4KL9 A;  4ELG A;  3QLX A;  3JWF A;  3VCO A;  1DR4 A;  3NXY A;  3KJS A;  3DL5 A;  4KEB A;  1IA3 A;  3I3R A;  2W9S A;  4QLF A;  3TQA A;  2XW7 A;  2ITH A;  3QLW A;  4XE6 X;  3FQZ A;  4P3Q A;  1DIS A;  5HVB A;  4X5G A;  4TU5 X;  4PTH A;  1RX5 A;  3QYL A;  3KJR A;  1IA4 A;  3SRQ X;  3ZPC A;  3M09 A;  4KAK A;  1MVT A;  3UM8 A;  3I8A X;  2BLC A;  4KLX A;  3NZ6 X;  3ROA A;  3FY9 X;  4PTJ A;  1RD7 A;  3L3R A;  4M6L A;  2W9G A;  2W3M A;  1OHK A;  1DG7 A;  2HQP A;  3OAF A;  5HI6 A;  1S3Y A;  2W3A A;  3D80 A;  4OSG A;  3NZC X;  1BZF A;  3FQF A;  3FRD X;  1RX7 A;  3CL9 A;  1KMS A;  4DFR A;  3SAI A;  1RX1 A;  4M6J A;  4PSY A;  1QZF A;  4G8Z X;  4Q0D A;  4FGG A;  3N0H A;  1AI9 A;  1IA1 A;  2LF1 A;  4P68 A;  1LY3 A;  3FYV X;  4ELE A;  1DIU A;  3JWC A;  3EEM A;  1HFQ A;  3FRB X;  1RE7 A;  4IXF X;  3NXX A;  2GD9 A;  3IA4 A;  3E0B A;  2W9H A;  1JUV A;  5ECC A;  2P4G A;  4KM0 A;  4XT4 A;  3UM6 A;  1KLK A;  1DRB A;  3GHC A;  5E8Q A;  3IRO A;  4Q6A A;  1OHJ A;  2W9T A;  3NXT A;  4HA9 A;  3F0V X;  1DR5 A;  3IRN A;  3CSE A;  1RB2 A;  2JYB A;  4KJK A;  2CD2 A;  3FQ0 A;  3JWK A;  2L28 A;  1DRH A;  4Q0E A;  1DAJ A;  3JW5 A;  5HF2 X;  1DR3 A;  2D0K A;  3QG2 A;  3JW3 A;  1RG7 A;  4LAH X;  3DGA A;  5JG0 X;  3EIG A;  3F0X X;  3KY8 A;  1CD2 A;  1DLS A;  4DP3 A;  2QK8 A;  4I13 A;  3FQV A;  3JTW A;  4QI9 A;  1DF7 A;  4H98 A;  4EJ1 A;  1RH3 A;  3S7A A;  4ELH A;  1RX4 A;  1DDS A;  1CZ3 A;  3NZ9 X;  3SQY X;  3SRR X;  4KY8 A;  3KGY A;  3QYO A;  4X5J A;  3CD2 A;  4ELF A;  4XT6 A;  3FL9 A;  3IX9 A;  4PSS A;  1M7A A;  1U72 A;  1RA2 A;  4KJJ A;  1U70 A;  1RA1 A;  4LEK X;  4RGC A;  1PD9 A;  4P66 A;  3INV A;  2ANQ A;  4M2X A;  5ECX A;  4G3M A;  3EEJ A;  3K2H A;  5HT5 A;  1DR6 A;  2W3W A;  4P3R A;  3QLY A;  4LAE X;  2FZJ A;  4EIZ A;  1KMV A;  4XT8 A;  1DHI A;  3GI2 A;  5EAJ A;  1J3J A;  3SRW X;  3NTZ A;  3S9U A;  1DR1 A; 
#chains in the Genus database with same CATH homology
 1RA8 A;  5HVE A;  1MVS A;  3DAT A;  1RX3 A;  3FRF X;  3FY8 X;  1U71 A;  1DYJ A;  4H97 A;  3D84 X;  4DDR A;  4KM2 A;  1RX6 A;  2C2T A;  4X5H A;  1DDR A;  4KJL A;  1HFR A;  1DRA A;  4GH8 A;  4NX7 A;  5HF0 X;  1RB3 A;  3NZA X;  1DRE A;  3SGY A;  3NXV A;  4EIL A;  5CCC A;  1RX8 A;  2BLA A;  5HSR A;  4KY4 A;  3SA2 A;  4QJZ D;  3UM5 A;  3EEL A;  1S3U A;  3LG4 A;  4QHV A;  2AZN A;  4HOE A;  5JA3 A;  3M08 A;  4H95 A;  5DXV A;  3OCH A;  3IA5 A;  2OIP A;  3IRM A;  1DHF A;  5HPB A;  4KNE A;  1PD8 A;  2HXV A;  1DYI A;  1DYR A;  1VDR A;  4KFJ A;  1RF7 A;  4OR7 A;  1RA9 A;  4QJC A;  3SRS X;  3JWM A;  4PDJ A;  5FDA A;  3K45 A;  1AO8 A;  4HOG A;  8DFR A;  3F8Y A;  3NXR A;  3TD8 A;  4X5I A;  3DFR A;  4M6K A;  3ZPG A;  3GHV A;  1RA3 A;  3RG9 A;  6DFR A;  2OBC A;  4QLE A;  2DHF A;  1M78 A;  3GHW A;  2C2S A;  5CC9 A;  3FRA X;  2W3B A;  3QLZ A;  1TDR A;  4M7V A;  5DFR A;  3F0Q X;  3HBB A;  1DG8 A;  4KYA A;  4G95 A;  4FGH A;  3F91 A;  1HFP A;  3NU0 A;  1RC4 A;  3QLS A;  4Q67 A;  3JSU A;  3EEK A;  5HT4 A;  3QL0 A;  1J3K A;  2O7P A;  3DAU A;  1ZDR A;  3FL8 A;  3KFY A;  4DPH A;  4HOF A;  4XT7 A;  3K74 A;  3DG8 A;  2BLB A;  3NZB X;  5HUI A;  4LAG X;  1M79 A;  2ANO A;  1RX9 A;  3NRR A;  2FZH A;  1VJ3 A;  5HQZ A;  7DFR A;  4KBN A;  4ELB A;  4XEC X;  1AOE A;  3NZD A;  1E26 A;  4DPD A;  4IXE D;  1DG5 A;  3JVX A;  5U26 A;  1DHJ A;  3SRU X;  3SH2 A;  3SA1 A;  1DLR A;  2ZZA A;  3R33 A;  2W3V A;  4NX6 A;  1SEJ A;  4PST A;  1PDB A;  3EX8 A;  2INQ A;  3FQO A;  2CIG A;  4M7U A;  3Q1H A;  1RX2 A;  2D5N A;  3F0S X;  1DYH A;  4ECK A;  3F0U X;  4XRB A;  4QLG A;  3QFX A;  1BOZ A;  4FHB A;  4IXG X;  2G6V A;  3DRC A;  1IA2 A;  3FQC A;  1D1G A;  4EIG A;  1DR7 A;  1JOL A;  3CLB A;  3FRE X;  2DRC A;  5U27 A;  3QL3 A;  1J3I A;  3GYF A;  3F8Z A;  4H96 A;  3S3V A;  1LY4 A;  4CD2 A;  4HA7 A;  3SR5 X;  3TQ9 A;  2FZI A;  4I1N A;  2HM9 A;  4XT5 A;  1JOM A;  2BL9 A;  2B3Z A;  3F0B X;  1LUD A;  1DRF A;  1S3W A;  3QLR A;  1S3V A;  4KD7 A;  4X5F A;  3TQ8 A;  3NXO A;  3TQB A;  2H2Q A;  3HJ3 A;  3FS6 A;  3K47 A;  1YHO A;  2KGK A;  3FYW X;  3QGT A;  5HQY A;  3DL6 A;  5HSU A;  1DR2 A;  3RO9 A;  4KL9 A;  4ELG A;  3QLX A;  3JWF A;  3VCO A;  1DR4 A;  3NXY A;  3KJS A;  3DL5 A;  4KEB A;  1IA3 A;  3I3R A;  2W9S A;  4QLF A;  3TQA A;  2XW7 A;  2ITH A;  3QLW A;  4XE6 X;  3FQZ A;  4P3Q A;  1DIS A;  5HVB A;  4X5G A;  4TU5 X;  4PTH A;  1RX5 A;  3QYL A;  3KJR A;  1IA4 A;  3SRQ X;  3ZPC A;  3M09 A;  4KAK A;  1MVT A;  3UM8 A;  3I8A X;  2BLC A;  4KLX A;  3NZ6 X;  3ROA A;  3FY9 X;  4PTJ A;  1RD7 A;  3L3R A;  4M6L A;  2W9G A;  2W3M A;  1OHK A;  1DG7 A;  2HQP A;  3OAF A;  5HI6 A;  1S3Y A;  2W3A A;  3D80 A;  4OSG A;  3NZC X;  1BZF A;  3FQF A;  3FRD X;  1RX7 A;  3CL9 A;  1KMS A;  4DFR A;  3SAI A;  1RX1 A;  4M6J A;  4PSY A;  1QZF A;  4G8Z X;  4Q0D A;  4FGG A;  3N0H A;  1AI9 A;  1IA1 A;  2LF1 A;  4P68 A;  1LY3 A;  3FYV X;  4ELE A;  1DIU A;  3JWC A;  3EEM A;  1HFQ A;  3FRB X;  1RE7 A;  4IXF X;  3NXX A;  2GD9 A;  3IA4 A;  3E0B A;  2W9H A;  1JUV A;  5ECC A;  2P4G A;  4KM0 A;  4XT4 A;  3UM6 A;  1KLK A;  1DRB A;  3GHC A;  5E8Q A;  3IRO A;  4Q6A A;  1OHJ A;  2W9T A;  3NXT A;  4HA9 A;  3F0V X;  1DR5 A;  3IRN A;  3CSE A;  1RB2 A;  2JYB A;  4KJK A;  2CD2 A;  3FQ0 A;  3JWK A;  2L28 A;  1DRH A;  4Q0E A;  1DAJ A;  3JW5 A;  5HF2 X;  1DR3 A;  2D0K A;  3QG2 A;  3JW3 A;  1RG7 A;  4LAH X;  3DGA A;  5JG0 X;  3EIG A;  3F0X X;  3KY8 A;  1CD2 A;  1DLS A;  4DP3 A;  2QK8 A;  4I13 A;  3FQV A;  3JTW A;  4QI9 A;  1DF7 A;  4H98 A;  4EJ1 A;  1RH3 A;  3S7A A;  4ELH A;  1RX4 A;  1DDS A;  1CZ3 A;  3NZ9 X;  3SQY X;  3SRR X;  4KY8 A;  3KGY A;  3QYO A;  4X5J A;  3CD2 A;  4ELF A;  4XT6 A;  3FL9 A;  3IX9 A;  4PSS A;  1M7A A;  1U72 A;  1RA2 A;  4KJJ A;  1U70 A;  1RA1 A;  4LEK X;  4RGC A;  1PD9 A;  4P66 A;  3INV A;  2ANQ A;  4M2X A;  5ECX A;  4G3M A;  3EEJ A;  3K2H A;  5HT5 A;  1DR6 A;  2W3W A;  4P3R A;  3QLY A;  4LAE X;  2FZJ A;  4EIZ A;  1KMV A;  4XT8 A;  1DHI A;  3GI2 A;  5EAJ A;  1J3J A;  3SRW X;  3NTZ A;  3S9U A;  1DR1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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