4ELEA

Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
166
structure length
166
Chain Sequence
MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Bacillus anthracis
molecule keywords Dihydrofolate reductase
total genus 44
structure length 166
sequence length 166
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2012-04-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4eleA00
3F91A 2BLBA 3EELA 1RX8A 1TDRA 2HM9A 1DREA 3INVA 3EEJA 1YHOA 4ELGA 3QLSA 5FDAA 4NX7A 4KL9A 3JWMA 2OIPA 4KYAA 3IA5A 3KY8A 1DYJA 3LG4A 3QL0A 3QLZA 1DG5A 3SQYX 3GI2A 4FGGA 1M78A 4LAHX 2ITHA 4HA9A 3EIGA 4HOEA 4XE6X 4KBNA 4IXFX 3CL9A 3IRNA 3KJRA 2BLAA 4GH8A 3TQ9A 3K2HA 1KLKA 1MVSA 3JW3A 1RH3A 4X5HA 1S3VA 3FRAX 1LY3A 3OAFA 1RX2A 4XT5A 4H95A 1S3WA 1DF7A 3FQOA 3IRMA 1S3YA 1RF7A 1RX1A 4KJLA 2ZZAA 3NZ9X 1BOZA 3SH2A 2CIGA 3FQZA 3DATA 2FZJA 3SRWX 4ELFA 4KM0A 4QHVA 5DXVA 4XT7A 3ROAA 3TQ8A 4EILA 3CD2A 3F0BX 1DRBA 2ANQA 4QI9A 3FY9X 1DR2A 5HVBA 3I3RA 2KGKA 3FQCA 5EAJA 3ZPGA 4Q0EA 2HXVA 1AO8A 2W9HA 3KJSA 3FQ0A 4ECKA 2O7PA 3JTWA 2W9SA 3SGYA 4HOGA 1RD7A 1M7AA 3F0VX 1DR4A 5JG0X 3N0HA 1RA8A 1IA4A 3CSEA 3FYWX 1DRFA 5ECCA 2D5NA 3NXXA 1DR7A 4M6JA 4P68A 4TU5X 3M08A 3NTZA 3F0UX 3FRDX 3FRBX 1D1GA 4QLGA 3SRQX 4KD7A 4G8ZX 3D84X 1DDRA 4Q0DA 1CD2A 1RX7A 1RX5A 3DRCA 3M09A 3F0SX 4XT8A 2HQPA 3Q1HA 3KGYA 2INQA 3D80A 5DFRA 4HOFA 1HFPA 1U72A 3NXVA 1J3IA 3I8AX 1DR3A 4KM2A 2C2SA 4IXED 4IXGX 2W3MA 1RA1A 4DPHA 1IA3A 2GD9A 4KY4A 3DAUA 5E8QA 5HF2X 1DRAA 1AOEA 1KMSA 5ECXA 3HJ3A 4CD2A 2DHFA 1HFQA 1MVTA 4I1NA 5HF0X 1RA9A 1DG7A 1DRHA 3FQVA 3QLWA 3QGTA 1AI9A 1U71A 3JWCA 4KFJA 4OR7A 5HSRA 4X5JA 1VDRA 5U27A 4M6KA 3K47A 2OBCA 4QJCA 4HA7A 3FREX 3GYFA 2W3AA 4QJZD 3DFRA 4KNEA 1IA2A 1LUDA 1HFRA 2P4GA 4FGHA 1RB3A 1KMVA 8DFRA 2CD2A 3ZPCA 3VCOA 3NRRA 4NX6A 4M7UA 3E0BA 2W3BA 1RA3A 4Q67A 4LEKX 1RC4A 1LY4A 3UM5A 4PTHA 2D0KA 3TD8A 1J3JA 2B3ZA 1DR5A 1RX9A 1DYRA 3QLRA 3IROA 3GHWA 2BL9A 1JUVA 3QLXA 1DHIA 4FHBA 3KFYA 3QLYA 4P66A 3IA4A 1DHFA 2FZHA 3NZDA 3NXOA 1CZ3A 3NXRA 1IA1A 4KJKA 3F8ZA 3K45A 4EJ1A 4X5FA 2DRCA 4H96A 1DAJA 3JW5A 4PDJA 2LF1A 3S7AA 5CC9A 3DL6A 5HT5A 5U26A 1JOLA 4XT6A 3SRUX 4KJJA 1E26A 3SAIA 1QZFA 4Q6AA 3FS6A 2W9TA 2AZNA 5HUIA 4QLFA 3RG9A 3FRFX 5HPBA 3S9UA 3FQFA 4LAGX 5HQYA 3JVXA 1S3UA 1DR1A 2L28A 4I13A 5HT4A 1OHKA 4G3MA 3S3VA 3OCHA 2QK8A 3R33A 3L3RA 4OSGA 1U70A 4XECX 4EIGA 3NXYA 3F0XX 3JWFA 4H97A 4XT4A 4PTJA 1DISA 1RX6A 5CCCA 3NU0A 4M6LA 2JYBA 2XW7A 1SEJA 4DDRA 4EIZA 5JA3A 4G95A 1RG7A 1M79A 1DR6A 4PSYA 4ELHA 4H98A 4M7VA 3NZCX 4DPDA 3QL3A 3UM8A 1RB2A 2W3VA 3UM6A 2ANOA 5HVEA 3QFXA 3SA1A 3IX9A 3GHVA 3NZAX 1PDBA 5HQZA 2W9GA 3EEKA 1DLSA 1OHJA 4DP3A 1VJ3A 2FZIA 3FL9A 4KY8A 2W3WA 3NXTA 1J3KA 1DIUA 4PSSA 4XRBA 1ZDRA 3EX8A 4P3QA 4P3RA 4M2XA 3SRSX 4QLEA 2BLCA 3QYLA 1RX4A 1DG8A 3CLBA 3FY8X 3DG8A 3JSUA 1PD9A 3DGAA 3HBBA 1DHJA 4X5IA 3F0QX 4KLXA 3SRRX 1DLRA 3SR5X 3GHCA 3K74A 3NZ6X 1JOMA 2C2TA 3FL8A 3TQAA 4PSTA 3RO9A 3QG2A 5HSUA 5HI6A 4ELBA 1RX3A 1DYHA 3NZBX 4KEBA 4RGCA 3FYVX 3JWKA 1DDSA 2H2QA 1RE7A 1PD8A 7DFRA 4DFRA 4KAKA 4X5GA 3F8YA 3DL5A 4LAEX 1RA2A 3TQBA 4ELEA 3QYOA 3EEMA 3SA2A 6DFRA 1BZFA 2G6VA 1DYIA
chains in the Genus database with same CATH superfamily
3F91A 2BLBA 3EELA 1RX8A 1TDRA 2HM9A 1DREA 3INVA 3EEJA 1YHOA 4ELGA 3QLSA 5FDAA 4NX7A 4KL9A 3JWMA 2OIPA 4KYAA 3IA5A 3KY8A 1DYJA 3LG4A 3QL0A 3QLZA 1DG5A 3SQYX 3GI2A 4FGGA 1M78A 4LAHX 2ITHA 4HA9A 3EIGA 4HOEA 4XE6X 4KBNA 4IXFX 3CL9A 3IRNA 3KJRA 2BLAA 4GH8A 3TQ9A 3K2HA 1KLKA 1MVSA 3JW3A 1RH3A 4X5HA 1S3VA 3FRAX 1LY3A 3OAFA 1RX2A 4XT5A 4H95A 1S3WA 1DF7A 3FQOA 3IRMA 1S3YA 1RF7A 1RX1A 4KJLA 2ZZAA 3NZ9X 1BOZA 3SH2A 2CIGA 3FQZA 3DATA 2FZJA 3SRWX 4ELFA 4KM0A 4QHVA 5DXVA 4XT7A 3ROAA 3TQ8A 4EILA 3CD2A 3F0BX 1DRBA 2ANQA 4QI9A 3FY9X 1DR2A 5HVBA 3I3RA 2KGKA 3FQCA 5EAJA 3ZPGA 4Q0EA 2HXVA 1AO8A 2W9HA 3KJSA 3FQ0A 4ECKA 2O7PA 3JTWA 2W9SA 3SGYA 4HOGA 1RD7A 1M7AA 3F0VX 1DR4A 5JG0X 3N0HA 1RA8A 1IA4A 3CSEA 3FYWX 1DRFA 5ECCA 2D5NA 3NXXA 1DR7A 4M6JA 4P68A 4TU5X 3M08A 3NTZA 3F0UX 3FRDX 3FRBX 1D1GA 4QLGA 3SRQX 4KD7A 4G8ZX 3D84X 1DDRA 4Q0DA 1CD2A 1RX7A 1RX5A 3DRCA 3M09A 3F0SX 4XT8A 2HQPA 3Q1HA 3KGYA 2INQA 3D80A 5DFRA 4HOFA 1HFPA 1U72A 3NXVA 1J3IA 3I8AX 1DR3A 4KM2A 2C2SA 4IXED 4IXGX 2W3MA 1RA1A 4DPHA 1IA3A 2GD9A 4KY4A 3DAUA 5E8QA 5HF2X 1DRAA 1AOEA 1KMSA 5ECXA 3HJ3A 4CD2A 2DHFA 1HFQA 1MVTA 4I1NA 5HF0X 1RA9A 1DG7A 1DRHA 3FQVA 3QLWA 3QGTA 1AI9A 1U71A 3JWCA 4KFJA 4OR7A 5HSRA 4X5JA 1VDRA 5U27A 4M6KA 3K47A 2OBCA 4QJCA 4HA7A 3FREX 3GYFA 2W3AA 4QJZD 3DFRA 4KNEA 1IA2A 1LUDA 1HFRA 2P4GA 4FGHA 1RB3A 1KMVA 8DFRA 2CD2A 3ZPCA 3VCOA 3NRRA 4NX6A 4M7UA 3E0BA 2W3BA 1RA3A 4Q67A 4LEKX 1RC4A 1LY4A 3UM5A 4PTHA 2D0KA 3TD8A 1J3JA 2B3ZA 1DR5A 1RX9A 1DYRA 3QLRA 3IROA 3GHWA 2BL9A 1JUVA 3QLXA 1DHIA 4FHBA 3KFYA 3QLYA 4P66A 3IA4A 1DHFA 2FZHA 3NZDA 3NXOA 1CZ3A 3NXRA 1IA1A 4KJKA 3F8ZA 3K45A 4EJ1A 4X5FA 2DRCA 4H96A 1DAJA 3JW5A 4PDJA 2LF1A 3S7AA 5CC9A 3DL6A 5HT5A 5U26A 1JOLA 4XT6A 3SRUX 4KJJA 1E26A 3SAIA 1QZFA 4Q6AA 3FS6A 2W9TA 2AZNA 5HUIA 4QLFA 3RG9A 3FRFX 5HPBA 3S9UA 3FQFA 4LAGX 5HQYA 3JVXA 1S3UA 1DR1A 2L28A 4I13A 5HT4A 1OHKA 4G3MA 3S3VA 3OCHA 2QK8A 3R33A 3L3RA 4OSGA 1U70A 4XECX 4EIGA 3NXYA 3F0XX 3JWFA 4H97A 4XT4A 4PTJA 1DISA 1RX6A 5CCCA 3NU0A 4M6LA 2JYBA 2XW7A 1SEJA 4DDRA 4EIZA 5JA3A 4G95A 1RG7A 1M79A 1DR6A 4PSYA 4ELHA 4H98A 4M7VA 3NZCX 4DPDA 3QL3A 3UM8A 1RB2A 2W3VA 3UM6A 2ANOA 5HVEA 3QFXA 3SA1A 3IX9A 3GHVA 3NZAX 1PDBA 5HQZA 2W9GA 3EEKA 1DLSA 1OHJA 4DP3A 1VJ3A 2FZIA 3FL9A 4KY8A 2W3WA 3NXTA 1J3KA 1DIUA 4PSSA 4XRBA 1ZDRA 3EX8A 4P3QA 4P3RA 4M2XA 3SRSX 4QLEA 2BLCA 3QYLA 1RX4A 1DG8A 3CLBA 3FY8X 3DG8A 3JSUA 1PD9A 3DGAA 3HBBA 1DHJA 4X5IA 3F0QX 4KLXA 3SRRX 1DLRA 3SR5X 3GHCA 3K74A 3NZ6X 1JOMA 2C2TA 3FL8A 3TQAA 4PSTA 3RO9A 3QG2A 5HSUA 5HI6A 4ELBA 1RX3A 1DYHA 3NZBX 4KEBA 4RGCA 3FYVX 3JWKA 1DDSA 2H2QA 1RE7A 1PD8A 7DFRA 4DFRA 4KAKA 4X5GA 3F8YA 3DL5A 4LAEX 1RA2A 3TQBA 4ELEA 3QYOA 3EEMA 3SA2A 6DFRA 1BZFA 2G6VA 1DYIA
chains in the Genus database with same CATH topology
3F91A 2BLBA 3EELA 1RX8A 1TDRA 2HM9A 1DREA 3INVA 3EEJA 1YHOA 4ELGA 3QLSA 5FDAA 4NX7A 4KL9A 3JWMA 2OIPA 4KYAA 3IA5A 3KY8A 1DYJA 3LG4A 3QL0A 3QLZA 1DG5A 3SQYX 3GI2A 4FGGA 1M78A 4LAHX 2ITHA 4HA9A 3EIGA 4HOEA 4XE6X 4KBNA 4IXFX 3CL9A 3IRNA 3KJRA 2BLAA 4GH8A 3TQ9A 3K2HA 1KLKA 1MVSA 3JW3A 1RH3A 4X5HA 1S3VA 3FRAX 1LY3A 3OAFA 1RX2A 4XT5A 4H95A 1S3WA 1DF7A 3FQOA 3IRMA 1S3YA 1RF7A 1RX1A 4KJLA 2ZZAA 3NZ9X 1BOZA 3SH2A 2CIGA 3FQZA 3DATA 2FZJA 3SRWX 4ELFA 4KM0A 4QHVA 5DXVA 4XT7A 3ROAA 3TQ8A 4EILA 3CD2A 3F0BX 1DRBA 2ANQA 4QI9A 3FY9X 1DR2A 5HVBA 3I3RA 2KGKA 3FQCA 5EAJA 3ZPGA 4Q0EA 2HXVA 1AO8A 2W9HA 3KJSA 3FQ0A 4ECKA 2O7PA 3JTWA 2W9SA 3SGYA 4HOGA 1RD7A 1M7AA 3F0VX 1DR4A 5JG0X 3N0HA 1RA8A 1IA4A 3CSEA 3FYWX 1DRFA 5ECCA 2D5NA 3NXXA 1DR7A 4M6JA 4P68A 4TU5X 3M08A 3NTZA 3F0UX 3FRDX 3FRBX 1D1GA 4QLGA 3SRQX 4KD7A 4G8ZX 3D84X 1DDRA 4Q0DA 1CD2A 1RX7A 1RX5A 3DRCA 3M09A 3F0SX 4XT8A 2HQPA 3Q1HA 3KGYA 2INQA 3D80A 5DFRA 4HOFA 1HFPA 1U72A 3NXVA 1J3IA 3I8AX 1DR3A 4KM2A 2C2SA 4IXED 4IXGX 2W3MA 1RA1A 4DPHA 1IA3A 2GD9A 4KY4A 3DAUA 5E8QA 5HF2X 1DRAA 1AOEA 1KMSA 5ECXA 3HJ3A 4CD2A 2DHFA 1HFQA 1MVTA 4I1NA 5HF0X 1RA9A 1DG7A 1DRHA 3FQVA 3QLWA 3QGTA 1AI9A 1U71A 3JWCA 4KFJA 4OR7A 5HSRA 4X5JA 1VDRA 5U27A 4M6KA 3K47A 2OBCA 4QJCA 4HA7A 3FREX 3GYFA 2W3AA 4QJZD 3DFRA 4KNEA 1IA2A 1LUDA 1HFRA 2P4GA 4FGHA 1RB3A 1KMVA 8DFRA 2CD2A 3ZPCA 3VCOA 3NRRA 4NX6A 4M7UA 3E0BA 2W3BA 1RA3A 4Q67A 4LEKX 1RC4A 1LY4A 3UM5A 4PTHA 2D0KA 3TD8A 1J3JA 2B3ZA 1DR5A 1RX9A 1DYRA 3QLRA 3IROA 3GHWA 2BL9A 1JUVA 3QLXA 1DHIA 4FHBA 3KFYA 3QLYA 4P66A 3IA4A 1DHFA 2FZHA 3NZDA 3NXOA 1CZ3A 3NXRA 1IA1A 4KJKA 3F8ZA 3K45A 4EJ1A 4X5FA 2DRCA 4H96A 1DAJA 3JW5A 4PDJA 2LF1A 3S7AA 5CC9A 3DL6A 5HT5A 5U26A 1JOLA 4XT6A 3SRUX 4KJJA 1E26A 3SAIA 1QZFA 4Q6AA 3FS6A 2W9TA 2AZNA 5HUIA 4QLFA 3RG9A 3FRFX 5HPBA 3S9UA 3FQFA 4LAGX 5HQYA 3JVXA 1S3UA 1DR1A 2L28A 4I13A 5HT4A 1OHKA 4G3MA 3S3VA 3OCHA 2QK8A 3R33A 3L3RA 4OSGA 1U70A 4XECX 4EIGA 3NXYA 3F0XX 3JWFA 4H97A 4XT4A 4PTJA 1DISA 1RX6A 5CCCA 3NU0A 4M6LA 2JYBA 2XW7A 1SEJA 4DDRA 4EIZA 5JA3A 4G95A 1RG7A 1M79A 1DR6A 4PSYA 4ELHA 4H98A 4M7VA 3NZCX 4DPDA 3QL3A 3UM8A 1RB2A 2W3VA 3UM6A 2ANOA 5HVEA 3QFXA 3SA1A 3IX9A 3GHVA 3NZAX 1PDBA 5HQZA 2W9GA 3EEKA 1DLSA 1OHJA 4DP3A 1VJ3A 2FZIA 3FL9A 4KY8A 2W3WA 3NXTA 1J3KA 1DIUA 4PSSA 4XRBA 1ZDRA 3EX8A 4P3QA 4P3RA 4M2XA 3SRSX 4QLEA 2BLCA 3QYLA 1RX4A 1DG8A 3CLBA 3FY8X 3DG8A 3JSUA 1PD9A 3DGAA 3HBBA 1DHJA 4X5IA 3F0QX 4KLXA 3SRRX 1DLRA 3SR5X 3GHCA 3K74A 3NZ6X 1JOMA 2C2TA 3FL8A 3TQAA 4PSTA 3RO9A 3QG2A 5HSUA 5HI6A 4ELBA 1RX3A 1DYHA 3NZBX 4KEBA 4RGCA 3FYVX 3JWKA 1DDSA 2H2QA 1RE7A 1PD8A 7DFRA 4DFRA 4KAKA 4X5GA 3F8YA 3DL5A 4LAEX 1RA2A 3TQBA 4ELEA 3QYOA 3EEMA 3SA2A 6DFRA 1BZFA 2G6VA 1DYIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F91 A;  2BLB A;  3EEL A;  1RX8 A;  1TDR A;  2HM9 A;  1DRE A;  3INV A;  3EEJ A;  1YHO A;  4ELG A;  3QLS A;  5FDA A;  4NX7 A;  4KL9 A;  3JWM A;  2OIP A;  4KYA A;  3IA5 A;  3KY8 A;  1DYJ A;  3LG4 A;  3QL0 A;  3QLZ A;  1DG5 A;  3SQY X;  3GI2 A;  4FGG A;  1M78 A;  4LAH X;  2ITH A;  4HA9 A;  3EIG A;  4HOE A;  4XE6 X;  4KBN A;  4IXF X;  3CL9 A;  3IRN A;  3KJR A;  2BLA A;  4GH8 A;  3TQ9 A;  3K2H A;  1KLK A;  1MVS A;  3JW3 A;  1RH3 A;  4X5H A;  1S3V A;  3FRA X;  1LY3 A;  3OAF A;  1RX2 A;  4XT5 A;  4H95 A;  1S3W A;  1DF7 A;  3FQO A;  3IRM A;  1S3Y A;  1RF7 A;  1RX1 A;  4KJL A;  2ZZA A;  3NZ9 X;  1BOZ A;  3SH2 A;  2CIG A;  3FQZ A;  3DAT A;  2FZJ A;  3SRW X;  4ELF A;  4KM0 A;  4QHV A;  5DXV A;  4XT7 A;  3ROA A;  3TQ8 A;  4EIL A;  3CD2 A;  3F0B X;  1DRB A;  2ANQ A;  4QI9 A;  3FY9 X;  1DR2 A;  5HVB A;  3I3R A;  2KGK A;  3FQC A;  5EAJ A;  3ZPG A;  4Q0E A;  2HXV A;  1AO8 A;  2W9H A;  3KJS A;  3FQ0 A;  4ECK A;  2O7P A;  3JTW A;  2W9S A;  3SGY A;  4HOG A;  1RD7 A;  1M7A A;  3F0V X;  1DR4 A;  5JG0 X;  3N0H A;  1RA8 A;  1IA4 A;  3CSE A;  3FYW X;  1DRF A;  5ECC A;  2D5N A;  3NXX A;  1DR7 A;  4M6J A;  4P68 A;  4TU5 X;  3M08 A;  3NTZ A;  3F0U X;  3FRD X;  3FRB X;  1D1G A;  4QLG A;  3SRQ X;  4KD7 A;  4G8Z X;  3D84 X;  1DDR A;  4Q0D A;  1CD2 A;  1RX7 A;  1RX5 A;  3DRC A;  3M09 A;  3F0S X;  4XT8 A;  2HQP A;  3Q1H A;  3KGY A;  2INQ A;  3D80 A;  5DFR A;  4HOF A;  1HFP A;  1U72 A;  3NXV A;  1J3I A;  3I8A X;  1DR3 A;  4KM2 A;  2C2S A;  4IXE D;  4IXG X;  2W3M A;  1RA1 A;  4DPH A;  1IA3 A;  2GD9 A;  4KY4 A;  3DAU A;  5E8Q A;  5HF2 X;  1DRA A;  1AOE A;  1KMS A;  5ECX A;  3HJ3 A;  4CD2 A;  2DHF A;  1HFQ A;  1MVT A;  4I1N A;  5HF0 X;  1RA9 A;  1DG7 A;  1DRH A;  3FQV A;  3QLW A;  3QGT A;  1AI9 A;  1U71 A;  3JWC A;  4KFJ A;  4OR7 A;  5HSR A;  4X5J A;  1VDR A;  5U27 A;  4M6K A;  3K47 A;  2OBC A;  4QJC A;  4HA7 A;  3FRE X;  3GYF A;  2W3A A;  4QJZ D;  3DFR A;  4KNE A;  1IA2 A;  1LUD A;  1HFR A;  2P4G A;  4FGH A;  1RB3 A;  1KMV A;  8DFR A;  2CD2 A;  3ZPC A;  3VCO A;  3NRR A;  4NX6 A;  4M7U A;  3E0B A;  2W3B A;  1RA3 A;  4Q67 A;  4LEK X;  1RC4 A;  1LY4 A;  3UM5 A;  4PTH A;  2D0K A;  3TD8 A;  1J3J A;  2B3Z A;  1DR5 A;  1RX9 A;  1DYR A;  3QLR A;  3IRO A;  3GHW A;  2BL9 A;  1JUV A;  3QLX A;  1DHI A;  4FHB A;  3KFY A;  3QLY A;  4P66 A;  3IA4 A;  1DHF A;  2FZH A;  3NZD A;  3NXO A;  1CZ3 A;  3NXR A;  1IA1 A;  4KJK A;  3F8Z A;  3K45 A;  4EJ1 A;  4X5F A;  2DRC A;  4H96 A;  1DAJ A;  3JW5 A;  4PDJ A;  2LF1 A;  3S7A A;  5CC9 A;  3DL6 A;  5HT5 A;  5U26 A;  1JOL A;  4XT6 A;  3SRU X;  4KJJ A;  1E26 A;  3SAI A;  1QZF A;  4Q6A A;  3FS6 A;  2W9T A;  2AZN A;  5HUI A;  4QLF A;  3RG9 A;  3FRF X;  5HPB A;  3S9U A;  3FQF A;  4LAG X;  5HQY A;  3JVX A;  1S3U A;  1DR1 A;  2L28 A;  4I13 A;  5HT4 A;  1OHK A;  4G3M A;  3S3V A;  3OCH A;  2QK8 A;  3R33 A;  3L3R A;  4OSG A;  1U70 A;  4XEC X;  4EIG A;  3NXY A;  3F0X X;  3JWF A;  4H97 A;  4XT4 A;  4PTJ A;  1DIS A;  1RX6 A;  5CCC A;  3NU0 A;  4M6L A;  2JYB A;  2XW7 A;  1SEJ A;  4DDR A;  4EIZ A;  5JA3 A;  4G95 A;  1RG7 A;  1M79 A;  1DR6 A;  4PSY A;  4ELH A;  4H98 A;  4M7V A;  3NZC X;  4DPD A;  3QL3 A;  3UM8 A;  1RB2 A;  2W3V A;  3UM6 A;  2ANO A;  5HVE A;  3QFX A;  3SA1 A;  3IX9 A;  3GHV A;  3NZA X;  1PDB A;  5HQZ A;  2W9G A;  3EEK A;  1DLS A;  1OHJ A;  4DP3 A;  1VJ3 A;  2FZI A;  3FL9 A;  4KY8 A;  2W3W A;  3NXT A;  1J3K A;  1DIU A;  4PSS A;  4XRB A;  1ZDR A;  3EX8 A;  4P3Q A;  4P3R A;  4M2X A;  3SRS X;  4QLE A;  2BLC A;  3QYL A;  1RX4 A;  1DG8 A;  3CLB A;  3FY8 X;  3DG8 A;  3JSU A;  1PD9 A;  3DGA A;  3HBB A;  1DHJ A;  4X5I A;  3F0Q X;  4KLX A;  3SRR X;  1DLR A;  3SR5 X;  3GHC A;  3K74 A;  3NZ6 X;  1JOM A;  2C2T A;  3FL8 A;  3TQA A;  4PST A;  3RO9 A;  3QG2 A;  5HSU A;  5HI6 A;  4ELB A;  1RX3 A;  1DYH A;  3NZB X;  4KEB A;  4RGC A;  3FYV X;  3JWK A;  1DDS A;  2H2Q A;  1RE7 A;  1PD8 A;  7DFR A;  4DFR A;  4KAK A;  4X5G A;  3F8Y A;  3DL5 A;  4LAE X;  1RA2 A;  3TQB A;  4ELE A;  3QYO A;  3EEM A;  3SA2 A;  6DFR A;  1BZF A;  2G6V A;  1DYI A; 
#chains in the Genus database with same CATH topology
 3F91 A;  2BLB A;  3EEL A;  1RX8 A;  1TDR A;  2HM9 A;  1DRE A;  3INV A;  3EEJ A;  1YHO A;  4ELG A;  3QLS A;  5FDA A;  4NX7 A;  4KL9 A;  3JWM A;  2OIP A;  4KYA A;  3IA5 A;  3KY8 A;  1DYJ A;  3LG4 A;  3QL0 A;  3QLZ A;  1DG5 A;  3SQY X;  3GI2 A;  4FGG A;  1M78 A;  4LAH X;  2ITH A;  4HA9 A;  3EIG A;  4HOE A;  4XE6 X;  4KBN A;  4IXF X;  3CL9 A;  3IRN A;  3KJR A;  2BLA A;  4GH8 A;  3TQ9 A;  3K2H A;  1KLK A;  1MVS A;  3JW3 A;  1RH3 A;  4X5H A;  1S3V A;  3FRA X;  1LY3 A;  3OAF A;  1RX2 A;  4XT5 A;  4H95 A;  1S3W A;  1DF7 A;  3FQO A;  3IRM A;  1S3Y A;  1RF7 A;  1RX1 A;  4KJL A;  2ZZA A;  3NZ9 X;  1BOZ A;  3SH2 A;  2CIG A;  3FQZ A;  3DAT A;  2FZJ A;  3SRW X;  4ELF A;  4KM0 A;  4QHV A;  5DXV A;  4XT7 A;  3ROA A;  3TQ8 A;  4EIL A;  3CD2 A;  3F0B X;  1DRB A;  2ANQ A;  4QI9 A;  3FY9 X;  1DR2 A;  5HVB A;  3I3R A;  2KGK A;  3FQC A;  5EAJ A;  3ZPG A;  4Q0E A;  2HXV A;  1AO8 A;  2W9H A;  3KJS A;  3FQ0 A;  4ECK A;  2O7P A;  3JTW A;  2W9S A;  3SGY A;  4HOG A;  1RD7 A;  1M7A A;  3F0V X;  1DR4 A;  5JG0 X;  3N0H A;  1RA8 A;  1IA4 A;  3CSE A;  3FYW X;  1DRF A;  5ECC A;  2D5N A;  3NXX A;  1DR7 A;  4M6J A;  4P68 A;  4TU5 X;  3M08 A;  3NTZ A;  3F0U X;  3FRD X;  3FRB X;  1D1G A;  4QLG A;  3SRQ X;  4KD7 A;  4G8Z X;  3D84 X;  1DDR A;  4Q0D A;  1CD2 A;  1RX7 A;  1RX5 A;  3DRC A;  3M09 A;  3F0S X;  4XT8 A;  2HQP A;  3Q1H A;  3KGY A;  2INQ A;  3D80 A;  5DFR A;  4HOF A;  1HFP A;  1U72 A;  3NXV A;  1J3I A;  3I8A X;  1DR3 A;  4KM2 A;  2C2S A;  4IXE D;  4IXG X;  2W3M A;  1RA1 A;  4DPH A;  1IA3 A;  2GD9 A;  4KY4 A;  3DAU A;  5E8Q A;  5HF2 X;  1DRA A;  1AOE A;  1KMS A;  5ECX A;  3HJ3 A;  4CD2 A;  2DHF A;  1HFQ A;  1MVT A;  4I1N A;  5HF0 X;  1RA9 A;  1DG7 A;  1DRH A;  3FQV A;  3QLW A;  3QGT A;  1AI9 A;  1U71 A;  3JWC A;  4KFJ A;  4OR7 A;  5HSR A;  4X5J A;  1VDR A;  5U27 A;  4M6K A;  3K47 A;  2OBC A;  4QJC A;  4HA7 A;  3FRE X;  3GYF A;  2W3A A;  4QJZ D;  3DFR A;  4KNE A;  1IA2 A;  1LUD A;  1HFR A;  2P4G A;  4FGH A;  1RB3 A;  1KMV A;  8DFR A;  2CD2 A;  3ZPC A;  3VCO A;  3NRR A;  4NX6 A;  4M7U A;  3E0B A;  2W3B A;  1RA3 A;  4Q67 A;  4LEK X;  1RC4 A;  1LY4 A;  3UM5 A;  4PTH A;  2D0K A;  3TD8 A;  1J3J A;  2B3Z A;  1DR5 A;  1RX9 A;  1DYR A;  3QLR A;  3IRO A;  3GHW A;  2BL9 A;  1JUV A;  3QLX A;  1DHI A;  4FHB A;  3KFY A;  3QLY A;  4P66 A;  3IA4 A;  1DHF A;  2FZH A;  3NZD A;  3NXO A;  1CZ3 A;  3NXR A;  1IA1 A;  4KJK A;  3F8Z A;  3K45 A;  4EJ1 A;  4X5F A;  2DRC A;  4H96 A;  1DAJ A;  3JW5 A;  4PDJ A;  2LF1 A;  3S7A A;  5CC9 A;  3DL6 A;  5HT5 A;  5U26 A;  1JOL A;  4XT6 A;  3SRU X;  4KJJ A;  1E26 A;  3SAI A;  1QZF A;  4Q6A A;  3FS6 A;  2W9T A;  2AZN A;  5HUI A;  4QLF A;  3RG9 A;  3FRF X;  5HPB A;  3S9U A;  3FQF A;  4LAG X;  5HQY A;  3JVX A;  1S3U A;  1DR1 A;  2L28 A;  4I13 A;  5HT4 A;  1OHK A;  4G3M A;  3S3V A;  3OCH A;  2QK8 A;  3R33 A;  3L3R A;  4OSG A;  1U70 A;  4XEC X;  4EIG A;  3NXY A;  3F0X X;  3JWF A;  4H97 A;  4XT4 A;  4PTJ A;  1DIS A;  1RX6 A;  5CCC A;  3NU0 A;  4M6L A;  2JYB A;  2XW7 A;  1SEJ A;  4DDR A;  4EIZ A;  5JA3 A;  4G95 A;  1RG7 A;  1M79 A;  1DR6 A;  4PSY A;  4ELH A;  4H98 A;  4M7V A;  3NZC X;  4DPD A;  3QL3 A;  3UM8 A;  1RB2 A;  2W3V A;  3UM6 A;  2ANO A;  5HVE A;  3QFX A;  3SA1 A;  3IX9 A;  3GHV A;  3NZA X;  1PDB A;  5HQZ A;  2W9G A;  3EEK A;  1DLS A;  1OHJ A;  4DP3 A;  1VJ3 A;  2FZI A;  3FL9 A;  4KY8 A;  2W3W A;  3NXT A;  1J3K A;  1DIU A;  4PSS A;  4XRB A;  1ZDR A;  3EX8 A;  4P3Q A;  4P3R A;  4M2X A;  3SRS X;  4QLE A;  2BLC A;  3QYL A;  1RX4 A;  1DG8 A;  3CLB A;  3FY8 X;  3DG8 A;  3JSU A;  1PD9 A;  3DGA A;  3HBB A;  1DHJ A;  4X5I A;  3F0Q X;  4KLX A;  3SRR X;  1DLR A;  3SR5 X;  3GHC A;  3K74 A;  3NZ6 X;  1JOM A;  2C2T A;  3FL8 A;  3TQA A;  4PST A;  3RO9 A;  3QG2 A;  5HSU A;  5HI6 A;  4ELB A;  1RX3 A;  1DYH A;  3NZB X;  4KEB A;  4RGC A;  3FYV X;  3JWK A;  1DDS A;  2H2Q A;  1RE7 A;  1PD8 A;  7DFR A;  4DFR A;  4KAK A;  4X5G A;  3F8Y A;  3DL5 A;  4LAE X;  1RA2 A;  3TQB A;  4ELE A;  3QYO A;  3EEM A;  3SA2 A;  6DFR A;  1BZF A;  2G6V A;  1DYI A; 
#chains in the Genus database with same CATH homology
 3F91 A;  2BLB A;  3EEL A;  1RX8 A;  1TDR A;  2HM9 A;  1DRE A;  3INV A;  3EEJ A;  1YHO A;  4ELG A;  3QLS A;  5FDA A;  4NX7 A;  4KL9 A;  3JWM A;  2OIP A;  4KYA A;  3IA5 A;  3KY8 A;  1DYJ A;  3LG4 A;  3QL0 A;  3QLZ A;  1DG5 A;  3SQY X;  3GI2 A;  4FGG A;  1M78 A;  4LAH X;  2ITH A;  4HA9 A;  3EIG A;  4HOE A;  4XE6 X;  4KBN A;  4IXF X;  3CL9 A;  3IRN A;  3KJR A;  2BLA A;  4GH8 A;  3TQ9 A;  3K2H A;  1KLK A;  1MVS A;  3JW3 A;  1RH3 A;  4X5H A;  1S3V A;  3FRA X;  1LY3 A;  3OAF A;  1RX2 A;  4XT5 A;  4H95 A;  1S3W A;  1DF7 A;  3FQO A;  3IRM A;  1S3Y A;  1RF7 A;  1RX1 A;  4KJL A;  2ZZA A;  3NZ9 X;  1BOZ A;  3SH2 A;  2CIG A;  3FQZ A;  3DAT A;  2FZJ A;  3SRW X;  4ELF A;  4KM0 A;  4QHV A;  5DXV A;  4XT7 A;  3ROA A;  3TQ8 A;  4EIL A;  3CD2 A;  3F0B X;  1DRB A;  2ANQ A;  4QI9 A;  3FY9 X;  1DR2 A;  5HVB A;  3I3R A;  2KGK A;  3FQC A;  5EAJ A;  3ZPG A;  4Q0E A;  2HXV A;  1AO8 A;  2W9H A;  3KJS A;  3FQ0 A;  4ECK A;  2O7P A;  3JTW A;  2W9S A;  3SGY A;  4HOG A;  1RD7 A;  1M7A A;  3F0V X;  1DR4 A;  5JG0 X;  3N0H A;  1RA8 A;  1IA4 A;  3CSE A;  3FYW X;  1DRF A;  5ECC A;  2D5N A;  3NXX A;  1DR7 A;  4M6J A;  4P68 A;  4TU5 X;  3M08 A;  3NTZ A;  3F0U X;  3FRD X;  3FRB X;  1D1G A;  4QLG A;  3SRQ X;  4KD7 A;  4G8Z X;  3D84 X;  1DDR A;  4Q0D A;  1CD2 A;  1RX7 A;  1RX5 A;  3DRC A;  3M09 A;  3F0S X;  4XT8 A;  2HQP A;  3Q1H A;  3KGY A;  2INQ A;  3D80 A;  5DFR A;  4HOF A;  1HFP A;  1U72 A;  3NXV A;  1J3I A;  3I8A X;  1DR3 A;  4KM2 A;  2C2S A;  4IXE D;  4IXG X;  2W3M A;  1RA1 A;  4DPH A;  1IA3 A;  2GD9 A;  4KY4 A;  3DAU A;  5E8Q A;  5HF2 X;  1DRA A;  1AOE A;  1KMS A;  5ECX A;  3HJ3 A;  4CD2 A;  2DHF A;  1HFQ A;  1MVT A;  4I1N A;  5HF0 X;  1RA9 A;  1DG7 A;  1DRH A;  3FQV A;  3QLW A;  3QGT A;  1AI9 A;  1U71 A;  3JWC A;  4KFJ A;  4OR7 A;  5HSR A;  4X5J A;  1VDR A;  5U27 A;  4M6K A;  3K47 A;  2OBC A;  4QJC A;  4HA7 A;  3FRE X;  3GYF A;  2W3A A;  4QJZ D;  3DFR A;  4KNE A;  1IA2 A;  1LUD A;  1HFR A;  2P4G A;  4FGH A;  1RB3 A;  1KMV A;  8DFR A;  2CD2 A;  3ZPC A;  3VCO A;  3NRR A;  4NX6 A;  4M7U A;  3E0B A;  2W3B A;  1RA3 A;  4Q67 A;  4LEK X;  1RC4 A;  1LY4 A;  3UM5 A;  4PTH A;  2D0K A;  3TD8 A;  1J3J A;  2B3Z A;  1DR5 A;  1RX9 A;  1DYR A;  3QLR A;  3IRO A;  3GHW A;  2BL9 A;  1JUV A;  3QLX A;  1DHI A;  4FHB A;  3KFY A;  3QLY A;  4P66 A;  3IA4 A;  1DHF A;  2FZH A;  3NZD A;  3NXO A;  1CZ3 A;  3NXR A;  1IA1 A;  4KJK A;  3F8Z A;  3K45 A;  4EJ1 A;  4X5F A;  2DRC A;  4H96 A;  1DAJ A;  3JW5 A;  4PDJ A;  2LF1 A;  3S7A A;  5CC9 A;  3DL6 A;  5HT5 A;  5U26 A;  1JOL A;  4XT6 A;  3SRU X;  4KJJ A;  1E26 A;  3SAI A;  1QZF A;  4Q6A A;  3FS6 A;  2W9T A;  2AZN A;  5HUI A;  4QLF A;  3RG9 A;  3FRF X;  5HPB A;  3S9U A;  3FQF A;  4LAG X;  5HQY A;  3JVX A;  1S3U A;  1DR1 A;  2L28 A;  4I13 A;  5HT4 A;  1OHK A;  4G3M A;  3S3V A;  3OCH A;  2QK8 A;  3R33 A;  3L3R A;  4OSG A;  1U70 A;  4XEC X;  4EIG A;  3NXY A;  3F0X X;  3JWF A;  4H97 A;  4XT4 A;  4PTJ A;  1DIS A;  1RX6 A;  5CCC A;  3NU0 A;  4M6L A;  2JYB A;  2XW7 A;  1SEJ A;  4DDR A;  4EIZ A;  5JA3 A;  4G95 A;  1RG7 A;  1M79 A;  1DR6 A;  4PSY A;  4ELH A;  4H98 A;  4M7V A;  3NZC X;  4DPD A;  3QL3 A;  3UM8 A;  1RB2 A;  2W3V A;  3UM6 A;  2ANO A;  5HVE A;  3QFX A;  3SA1 A;  3IX9 A;  3GHV A;  3NZA X;  1PDB A;  5HQZ A;  2W9G A;  3EEK A;  1DLS A;  1OHJ A;  4DP3 A;  1VJ3 A;  2FZI A;  3FL9 A;  4KY8 A;  2W3W A;  3NXT A;  1J3K A;  1DIU A;  4PSS A;  4XRB A;  1ZDR A;  3EX8 A;  4P3Q A;  4P3R A;  4M2X A;  3SRS X;  4QLE A;  2BLC A;  3QYL A;  1RX4 A;  1DG8 A;  3CLB A;  3FY8 X;  3DG8 A;  3JSU A;  1PD9 A;  3DGA A;  3HBB A;  1DHJ A;  4X5I A;  3F0Q X;  4KLX A;  3SRR X;  1DLR A;  3SR5 X;  3GHC A;  3K74 A;  3NZ6 X;  1JOM A;  2C2T A;  3FL8 A;  3TQA A;  4PST A;  3RO9 A;  3QG2 A;  5HSU A;  5HI6 A;  4ELB A;  1RX3 A;  1DYH A;  3NZB X;  4KEB A;  4RGC A;  3FYV X;  3JWK A;  1DDS A;  2H2Q A;  1RE7 A;  1PD8 A;  7DFR A;  4DFR A;  4KAK A;  4X5G A;  3F8Y A;  3DL5 A;  4LAE X;  1RA2 A;  3TQB A;  4ELE A;  3QYO A;  3EEM A;  3SA2 A;  6DFR A;  1BZF A;  2G6V A;  1DYI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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