4FGHA

S. aureus dihydrofolate reductase co-crystallized with ethyl-dap isobutenyl-dihydrophthalazine inhibitor
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
163
structure length
163
Chain Sequence
MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKKLVPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines.
pubmed doi rcsb
molecule tags Oxidoreductase/inhibitor
source organism Staphylococcus aureus
molecule keywords Dihydrofolate reductase
total genus 40
structure length 163
sequence length 163
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2012-06-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4fghA00
1IA2A 2P4GA 1CZ3A 3FL8A 4KM2A 3HJ3A 1HFPA 1DAJA 1DRHA 3JVXA 2G6VA 3IX9A 2XW7A 4KBNA 3FQVA 3I8AX 5ECCA 1DDRA 3FQOA 4M6LA 1LY4A 3SRQX 5HI6A 3F8YA 3NU0A 1HFRA 4EIZA 1PDBA 3SRUX 3UM6A 1RX9A 3FRBX 1U71A 1DR5A 1QZFA 2D0KA 1DF7A 1M7AA 4XT4A 3DG8A 4KM0A 1U72A 3NZAX 5HSUA 3FQ0A 3FRDX 3K45A 4QHVA 3QFXA 5E8QA 4M6JA 4PDJA 1YHOA 3KFYA 3TD8A 3OAFA 1DYRA 3Q1HA 3TQ9A 2W3BA 2CD2A 1DRFA 5HT4A 1RH3A 3JSUA 3N0HA 2LF1A 2W9GA 4EILA 3DAUA 1IA3A 4DPHA 3SRSX 1DR1A 3FREX 4H96A 4QJZD 5HQYA 3VCOA 4PTJA 4LEKX 4ELFA 1DHFA 4ELHA 4KJLA 4IXGX 3SR5X 1KMSA 2INQA 3EEJA 4GH8A 3UM8A 4CD2A 3K47A 3F0QX 1AOEA 3TQAA 2BLBA 3S7AA 4X5FA 1JUVA 1S3WA 5HVBA 2QK8A 3FS6A 4P3RA 1DG7A 3JWCA 1DYHA 4PSSA 4DDRA 5JA3A 1CD2A 3EEMA 3QLRA 1RE7A 1OHJA 4DPDA 3F91A 3IROA 1PD8A 3ZPCA 4PTHA 2W3VA 3JW3A 5JG0X 3CD2A 3DATA 3FL9A 5DXVA 5FDAA 1RA2A 4QLEA 1IA4A 2B3ZA 4M7VA 1RC4A 4G8ZX 2BL9A 4Q0DA 2W9HA 1BZFA 2ANQA 1DRAA 1DLSA 1DG8A 3HBBA 4HOGA 3SAIA 3F0VX 3S3VA 3SA2A 4XT5A 1U70A 2ITHA 3CL9A 1RX2A 1HFQA 1JOLA 3NTZA 5HPBA 4KNEA 3F8ZA 4DFRA 3IA5A 4KD7A 3FQCA 1RA8A 2HXVA 7DFRA 1RX6A 3D84X 4KJKA 4KL9A 2AZNA 4XRBA 1KMVA 3NXVA 1DREA 1TDRA 1RB2A 2JYBA 4QI9A 3UM5A 4I13A 4KY4A 1RG7A 3SA1A 3GHCA 3QLZA 3RG9A 5HVEA 3IRMA 2DHFA 3JWKA 4LAEX 1RA9A 4LAHX 4KYAA 5HUIA 3FYWX 1LY3A 3QLSA 4EJ1A 1MVTA 3NZDA 4FGHA 3JTWA 5CCCA 3CSEA 4H98A 2OBCA 3DRCA 1J3IA 4H95A 4M7UA 4HOEA 1DYIA 3NZBX 4M6KA 4LAGX 4FGGA 4OSGA 3K74A 5CC9A 2CIGA 3KGYA 3R33A 3QYOA 1S3VA 3E0BA 1RA3A 2W9SA 4Q67A 1DR2A 3NXXA 3SRRX 1DISA 4QLFA 5ECXA 3I3RA 4QJCA 3F0XX 1DG5A 3IA4A 1DR3A 4XE6X 4ELGA 2ZZAA 1DDSA 2W3WA 3DL6A 3F0UX 1JOMA 2W3MA 3FQZA 4P3QA 4RGCA 3RO9A 2H2QA 1SEJA 3NZ9X 3KJRA 3FRFX 4X5IA 4HA7A 4P66A 4G3MA 4X5HA 4KAKA 1S3UA 4Q0EA 3IRNA 2HM9A 5HF0X 1KLKA 1S3YA 2DRCA 3EX8A 4KFJA 1DHIA 3L3RA 2W3AA 1RX4A 3EIGA 3EEKA 3DL5A 3NZCX 4HOFA 2KGKA 3ROAA 4X5GA 1RX1A 1RB3A 3S9UA 1LUDA 3SQYX 1DR6A 4PSYA 2HQPA 3M09A 5U26A 4G95A 3F0SX 2ANOA 3GYFA 3LG4A 3TQ8A 3DGAA 4DP3A 2BLAA 3D80A 3QG2A 4KY8A 4EIGA 3NXTA 5HQZA 2OIPA 3FQFA 3NRRA 3QL3A 3QLXA 1M79A 4NX6A 3FYVX 1BOZA 1VJ3A 1M78A 3NZ6X 4HA9A 3GHWA 5DFRA 4P68A 3FRAX 1DIUA 1DRBA 4ECKA 1J3KA 3OCHA 2FZHA 3KY8A 3QLYA 3SGYA 3JWMA 1DHJA 1ZDRA 3SH2A 3JW5A 4Q6AA 1OHKA 4XT6A 4FHBA 1RF7A 1DYJA 3QL0A 1RA1A 1DR4A 4XT7A 1DLRA 2BLCA 4X5JA 5HF2X 3K2HA 3TQBA 1RX3A 4KEBA 2O7PA 1IA1A 3NXOA 1D1GA 1DR7A 1RX5A 4XT8A 1PD9A 1AI9A 4QLGA 2FZIA 3EELA 3GHVA 4KJJA 4PSTA 3GI2A 3INVA 1VDRA 4I1NA 2D5NA 3CLBA 2GD9A 3NXRA 4XECX 3QLWA 2W9TA 3SRWX 6DFRA 2L28A 4IXED 5U27A 1MVSA 3QYLA 1AO8A 3KJSA 4ELBA 1RX7A 4KLXA 1E26A 2C2SA 3JWFA 3FY8X 3M08A 4IXFX 3NXYA 2FZJA 4NX7A 5HT5A 5HSRA 1RX8A 5EAJA 1J3JA 8DFRA 4M2XA 2C2TA 4OR7A 1RD7A 4ELEA 4H97A 3DFRA 3QGTA 3ZPGA 3F0BX 3FY9X 4TU5X
chains in the Genus database with same CATH superfamily
1IA2A 2P4GA 1CZ3A 3FL8A 4KM2A 3HJ3A 1HFPA 1DAJA 1DRHA 3JVXA 2G6VA 3IX9A 2XW7A 4KBNA 3FQVA 3I8AX 5ECCA 1DDRA 3FQOA 4M6LA 1LY4A 3SRQX 5HI6A 3F8YA 3NU0A 1HFRA 4EIZA 1PDBA 3SRUX 3UM6A 1RX9A 3FRBX 1U71A 1DR5A 1QZFA 2D0KA 1DF7A 1M7AA 4XT4A 3DG8A 4KM0A 1U72A 3NZAX 5HSUA 3FQ0A 3FRDX 3K45A 4QHVA 3QFXA 5E8QA 4M6JA 4PDJA 1YHOA 3KFYA 3TD8A 3OAFA 1DYRA 3Q1HA 3TQ9A 2W3BA 2CD2A 1DRFA 5HT4A 1RH3A 3JSUA 3N0HA 2LF1A 2W9GA 4EILA 3DAUA 1IA3A 4DPHA 3SRSX 1DR1A 3FREX 4H96A 4QJZD 5HQYA 3VCOA 4PTJA 4LEKX 4ELFA 1DHFA 4ELHA 4KJLA 4IXGX 3SR5X 1KMSA 2INQA 3EEJA 4GH8A 3UM8A 4CD2A 3K47A 3F0QX 1AOEA 3TQAA 2BLBA 3S7AA 4X5FA 1JUVA 1S3WA 5HVBA 2QK8A 3FS6A 4P3RA 1DG7A 3JWCA 1DYHA 4PSSA 4DDRA 5JA3A 1CD2A 3EEMA 3QLRA 1RE7A 1OHJA 4DPDA 3F91A 3IROA 1PD8A 3ZPCA 4PTHA 2W3VA 3JW3A 5JG0X 3CD2A 3DATA 3FL9A 5DXVA 5FDAA 1RA2A 4QLEA 1IA4A 2B3ZA 4M7VA 1RC4A 4G8ZX 2BL9A 4Q0DA 2W9HA 1BZFA 2ANQA 1DRAA 1DLSA 1DG8A 3HBBA 4HOGA 3SAIA 3F0VX 3S3VA 3SA2A 4XT5A 1U70A 2ITHA 3CL9A 1RX2A 1HFQA 1JOLA 3NTZA 5HPBA 4KNEA 3F8ZA 4DFRA 3IA5A 4KD7A 3FQCA 1RA8A 2HXVA 7DFRA 1RX6A 3D84X 4KJKA 4KL9A 2AZNA 4XRBA 1KMVA 3NXVA 1DREA 1TDRA 1RB2A 2JYBA 4QI9A 3UM5A 4I13A 4KY4A 1RG7A 3SA1A 3GHCA 3QLZA 3RG9A 5HVEA 3IRMA 2DHFA 3JWKA 4LAEX 1RA9A 4LAHX 4KYAA 5HUIA 3FYWX 1LY3A 3QLSA 4EJ1A 1MVTA 3NZDA 4FGHA 3JTWA 5CCCA 3CSEA 4H98A 2OBCA 3DRCA 1J3IA 4H95A 4M7UA 4HOEA 1DYIA 3NZBX 4M6KA 4LAGX 4FGGA 4OSGA 3K74A 5CC9A 2CIGA 3KGYA 3R33A 3QYOA 1S3VA 3E0BA 1RA3A 2W9SA 4Q67A 1DR2A 3NXXA 3SRRX 1DISA 4QLFA 5ECXA 3I3RA 4QJCA 3F0XX 1DG5A 3IA4A 1DR3A 4XE6X 4ELGA 2ZZAA 1DDSA 2W3WA 3DL6A 3F0UX 1JOMA 2W3MA 3FQZA 4P3QA 4RGCA 3RO9A 2H2QA 1SEJA 3NZ9X 3KJRA 3FRFX 4X5IA 4HA7A 4P66A 4G3MA 4X5HA 4KAKA 1S3UA 4Q0EA 3IRNA 2HM9A 5HF0X 1KLKA 1S3YA 2DRCA 3EX8A 4KFJA 1DHIA 3L3RA 2W3AA 1RX4A 3EIGA 3EEKA 3DL5A 3NZCX 4HOFA 2KGKA 3ROAA 4X5GA 1RX1A 1RB3A 3S9UA 1LUDA 3SQYX 1DR6A 4PSYA 2HQPA 3M09A 5U26A 4G95A 3F0SX 2ANOA 3GYFA 3LG4A 3TQ8A 3DGAA 4DP3A 2BLAA 3D80A 3QG2A 4KY8A 4EIGA 3NXTA 5HQZA 2OIPA 3FQFA 3NRRA 3QL3A 3QLXA 1M79A 4NX6A 3FYVX 1BOZA 1VJ3A 1M78A 3NZ6X 4HA9A 3GHWA 5DFRA 4P68A 3FRAX 1DIUA 1DRBA 4ECKA 1J3KA 3OCHA 2FZHA 3KY8A 3QLYA 3SGYA 3JWMA 1DHJA 1ZDRA 3SH2A 3JW5A 4Q6AA 1OHKA 4XT6A 4FHBA 1RF7A 1DYJA 3QL0A 1RA1A 1DR4A 4XT7A 1DLRA 2BLCA 4X5JA 5HF2X 3K2HA 3TQBA 1RX3A 4KEBA 2O7PA 1IA1A 3NXOA 1D1GA 1DR7A 1RX5A 4XT8A 1PD9A 1AI9A 4QLGA 2FZIA 3EELA 3GHVA 4KJJA 4PSTA 3GI2A 3INVA 1VDRA 4I1NA 2D5NA 3CLBA 2GD9A 3NXRA 4XECX 3QLWA 2W9TA 3SRWX 6DFRA 2L28A 4IXED 5U27A 1MVSA 3QYLA 1AO8A 3KJSA 4ELBA 1RX7A 4KLXA 1E26A 2C2SA 3JWFA 3FY8X 3M08A 4IXFX 3NXYA 2FZJA 4NX7A 5HT5A 5HSRA 1RX8A 5EAJA 1J3JA 8DFRA 4M2XA 2C2TA 4OR7A 1RD7A 4ELEA 4H97A 3DFRA 3QGTA 3ZPGA 3F0BX 3FY9X 4TU5X
chains in the Genus database with same CATH topology
1IA2A 2P4GA 1CZ3A 3FL8A 4KM2A 3HJ3A 1HFPA 1DAJA 1DRHA 3JVXA 2G6VA 3IX9A 2XW7A 4KBNA 3FQVA 3I8AX 5ECCA 1DDRA 3FQOA 4M6LA 1LY4A 3SRQX 5HI6A 3F8YA 3NU0A 1HFRA 4EIZA 1PDBA 3SRUX 3UM6A 1RX9A 3FRBX 1U71A 1DR5A 1QZFA 2D0KA 1DF7A 1M7AA 4XT4A 3DG8A 4KM0A 1U72A 3NZAX 5HSUA 3FQ0A 3FRDX 3K45A 4QHVA 3QFXA 5E8QA 4M6JA 4PDJA 1YHOA 3KFYA 3TD8A 3OAFA 1DYRA 3Q1HA 3TQ9A 2W3BA 2CD2A 1DRFA 5HT4A 1RH3A 3JSUA 3N0HA 2LF1A 2W9GA 4EILA 3DAUA 1IA3A 4DPHA 3SRSX 1DR1A 3FREX 4H96A 4QJZD 5HQYA 3VCOA 4PTJA 4LEKX 4ELFA 1DHFA 4ELHA 4KJLA 4IXGX 3SR5X 1KMSA 2INQA 3EEJA 4GH8A 3UM8A 4CD2A 3K47A 3F0QX 1AOEA 3TQAA 2BLBA 3S7AA 4X5FA 1JUVA 1S3WA 5HVBA 2QK8A 3FS6A 4P3RA 1DG7A 3JWCA 1DYHA 4PSSA 4DDRA 5JA3A 1CD2A 3EEMA 3QLRA 1RE7A 1OHJA 4DPDA 3F91A 3IROA 1PD8A 3ZPCA 4PTHA 2W3VA 3JW3A 5JG0X 3CD2A 3DATA 3FL9A 5DXVA 5FDAA 1RA2A 4QLEA 1IA4A 2B3ZA 4M7VA 1RC4A 4G8ZX 2BL9A 4Q0DA 2W9HA 1BZFA 2ANQA 1DRAA 1DLSA 1DG8A 3HBBA 4HOGA 3SAIA 3F0VX 3S3VA 3SA2A 4XT5A 1U70A 2ITHA 3CL9A 1RX2A 1HFQA 1JOLA 3NTZA 5HPBA 4KNEA 3F8ZA 4DFRA 3IA5A 4KD7A 3FQCA 1RA8A 2HXVA 7DFRA 1RX6A 3D84X 4KJKA 4KL9A 2AZNA 4XRBA 1KMVA 3NXVA 1DREA 1TDRA 1RB2A 2JYBA 4QI9A 3UM5A 4I13A 4KY4A 1RG7A 3SA1A 3GHCA 3QLZA 3RG9A 5HVEA 3IRMA 2DHFA 3JWKA 4LAEX 1RA9A 4LAHX 4KYAA 5HUIA 3FYWX 1LY3A 3QLSA 4EJ1A 1MVTA 3NZDA 4FGHA 3JTWA 5CCCA 3CSEA 4H98A 2OBCA 3DRCA 1J3IA 4H95A 4M7UA 4HOEA 1DYIA 3NZBX 4M6KA 4LAGX 4FGGA 4OSGA 3K74A 5CC9A 2CIGA 3KGYA 3R33A 3QYOA 1S3VA 3E0BA 1RA3A 2W9SA 4Q67A 1DR2A 3NXXA 3SRRX 1DISA 4QLFA 5ECXA 3I3RA 4QJCA 3F0XX 1DG5A 3IA4A 1DR3A 4XE6X 4ELGA 2ZZAA 1DDSA 2W3WA 3DL6A 3F0UX 1JOMA 2W3MA 3FQZA 4P3QA 4RGCA 3RO9A 2H2QA 1SEJA 3NZ9X 3KJRA 3FRFX 4X5IA 4HA7A 4P66A 4G3MA 4X5HA 4KAKA 1S3UA 4Q0EA 3IRNA 2HM9A 5HF0X 1KLKA 1S3YA 2DRCA 3EX8A 4KFJA 1DHIA 3L3RA 2W3AA 1RX4A 3EIGA 3EEKA 3DL5A 3NZCX 4HOFA 2KGKA 3ROAA 4X5GA 1RX1A 1RB3A 3S9UA 1LUDA 3SQYX 1DR6A 4PSYA 2HQPA 3M09A 5U26A 4G95A 3F0SX 2ANOA 3GYFA 3LG4A 3TQ8A 3DGAA 4DP3A 2BLAA 3D80A 3QG2A 4KY8A 4EIGA 3NXTA 5HQZA 2OIPA 3FQFA 3NRRA 3QL3A 3QLXA 1M79A 4NX6A 3FYVX 1BOZA 1VJ3A 1M78A 3NZ6X 4HA9A 3GHWA 5DFRA 4P68A 3FRAX 1DIUA 1DRBA 4ECKA 1J3KA 3OCHA 2FZHA 3KY8A 3QLYA 3SGYA 3JWMA 1DHJA 1ZDRA 3SH2A 3JW5A 4Q6AA 1OHKA 4XT6A 4FHBA 1RF7A 1DYJA 3QL0A 1RA1A 1DR4A 4XT7A 1DLRA 2BLCA 4X5JA 5HF2X 3K2HA 3TQBA 1RX3A 4KEBA 2O7PA 1IA1A 3NXOA 1D1GA 1DR7A 1RX5A 4XT8A 1PD9A 1AI9A 4QLGA 2FZIA 3EELA 3GHVA 4KJJA 4PSTA 3GI2A 3INVA 1VDRA 4I1NA 2D5NA 3CLBA 2GD9A 3NXRA 4XECX 3QLWA 2W9TA 3SRWX 6DFRA 2L28A 4IXED 5U27A 1MVSA 3QYLA 1AO8A 3KJSA 4ELBA 1RX7A 4KLXA 1E26A 2C2SA 3JWFA 3FY8X 3M08A 4IXFX 3NXYA 2FZJA 4NX7A 5HT5A 5HSRA 1RX8A 5EAJA 1J3JA 8DFRA 4M2XA 2C2TA 4OR7A 1RD7A 4ELEA 4H97A 3DFRA 3QGTA 3ZPGA 3F0BX 3FY9X 4TU5X
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1IA2 A;  2P4G A;  1CZ3 A;  3FL8 A;  4KM2 A;  3HJ3 A;  1HFP A;  1DAJ A;  1DRH A;  3JVX A;  2G6V A;  3IX9 A;  2XW7 A;  4KBN A;  3FQV A;  3I8A X;  5ECC A;  1DDR A;  3FQO A;  4M6L A;  1LY4 A;  3SRQ X;  5HI6 A;  3F8Y A;  3NU0 A;  1HFR A;  4EIZ A;  1PDB A;  3SRU X;  3UM6 A;  1RX9 A;  3FRB X;  1U71 A;  1DR5 A;  1QZF A;  2D0K A;  1DF7 A;  1M7A A;  4XT4 A;  3DG8 A;  4KM0 A;  1U72 A;  3NZA X;  5HSU A;  3FQ0 A;  3FRD X;  3K45 A;  4QHV A;  3QFX A;  5E8Q A;  4M6J A;  4PDJ A;  1YHO A;  3KFY A;  3TD8 A;  3OAF A;  1DYR A;  3Q1H A;  3TQ9 A;  2W3B A;  2CD2 A;  1DRF A;  5HT4 A;  1RH3 A;  3JSU A;  3N0H A;  2LF1 A;  2W9G A;  4EIL A;  3DAU A;  1IA3 A;  4DPH A;  3SRS X;  1DR1 A;  3FRE X;  4H96 A;  4QJZ D;  5HQY A;  3VCO A;  4PTJ A;  4LEK X;  4ELF A;  1DHF A;  4ELH A;  4KJL A;  4IXG X;  3SR5 X;  1KMS A;  2INQ A;  3EEJ A;  4GH8 A;  3UM8 A;  4CD2 A;  3K47 A;  3F0Q X;  1AOE A;  3TQA A;  2BLB A;  3S7A A;  4X5F A;  1JUV A;  1S3W A;  5HVB A;  2QK8 A;  3FS6 A;  4P3R A;  1DG7 A;  3JWC A;  1DYH A;  4PSS A;  4DDR A;  5JA3 A;  1CD2 A;  3EEM A;  3QLR A;  1RE7 A;  1OHJ A;  4DPD A;  3F91 A;  3IRO A;  1PD8 A;  3ZPC A;  4PTH A;  2W3V A;  3JW3 A;  5JG0 X;  3CD2 A;  3DAT A;  3FL9 A;  5DXV A;  5FDA A;  1RA2 A;  4QLE A;  1IA4 A;  2B3Z A;  4M7V A;  1RC4 A;  4G8Z X;  2BL9 A;  4Q0D A;  2W9H A;  1BZF A;  2ANQ A;  1DRA A;  1DLS A;  1DG8 A;  3HBB A;  4HOG A;  3SAI A;  3F0V X;  3S3V A;  3SA2 A;  4XT5 A;  1U70 A;  2ITH A;  3CL9 A;  1RX2 A;  1HFQ A;  1JOL A;  3NTZ A;  5HPB A;  4KNE A;  3F8Z A;  4DFR A;  3IA5 A;  4KD7 A;  3FQC A;  1RA8 A;  2HXV A;  7DFR A;  1RX6 A;  3D84 X;  4KJK A;  4KL9 A;  2AZN A;  4XRB A;  1KMV A;  3NXV A;  1DRE A;  1TDR A;  1RB2 A;  2JYB A;  4QI9 A;  3UM5 A;  4I13 A;  4KY4 A;  1RG7 A;  3SA1 A;  3GHC A;  3QLZ A;  3RG9 A;  5HVE A;  3IRM A;  2DHF A;  3JWK A;  4LAE X;  1RA9 A;  4LAH X;  4KYA A;  5HUI A;  3FYW X;  1LY3 A;  3QLS A;  4EJ1 A;  1MVT A;  3NZD A;  4FGH A;  3JTW A;  5CCC A;  3CSE A;  4H98 A;  2OBC A;  3DRC A;  1J3I A;  4H95 A;  4M7U A;  4HOE A;  1DYI A;  3NZB X;  4M6K A;  4LAG X;  4FGG A;  4OSG A;  3K74 A;  5CC9 A;  2CIG A;  3KGY A;  3R33 A;  3QYO A;  1S3V A;  3E0B A;  1RA3 A;  2W9S A;  4Q67 A;  1DR2 A;  3NXX A;  3SRR X;  1DIS A;  4QLF A;  5ECX A;  3I3R A;  4QJC A;  3F0X X;  1DG5 A;  3IA4 A;  1DR3 A;  4XE6 X;  4ELG A;  2ZZA A;  1DDS A;  2W3W A;  3DL6 A;  3F0U X;  1JOM A;  2W3M A;  3FQZ A;  4P3Q A;  4RGC A;  3RO9 A;  2H2Q A;  1SEJ A;  3NZ9 X;  3KJR A;  3FRF X;  4X5I A;  4HA7 A;  4P66 A;  4G3M A;  4X5H A;  4KAK A;  1S3U A;  4Q0E A;  3IRN A;  2HM9 A;  5HF0 X;  1KLK A;  1S3Y A;  2DRC A;  3EX8 A;  4KFJ A;  1DHI A;  3L3R A;  2W3A A;  1RX4 A;  3EIG A;  3EEK A;  3DL5 A;  3NZC X;  4HOF A;  2KGK A;  3ROA A;  4X5G A;  1RX1 A;  1RB3 A;  3S9U A;  1LUD A;  3SQY X;  1DR6 A;  4PSY A;  2HQP A;  3M09 A;  5U26 A;  4G95 A;  3F0S X;  2ANO A;  3GYF A;  3LG4 A;  3TQ8 A;  3DGA A;  4DP3 A;  2BLA A;  3D80 A;  3QG2 A;  4KY8 A;  4EIG A;  3NXT A;  5HQZ A;  2OIP A;  3FQF A;  3NRR A;  3QL3 A;  3QLX A;  1M79 A;  4NX6 A;  3FYV X;  1BOZ A;  1VJ3 A;  1M78 A;  3NZ6 X;  4HA9 A;  3GHW A;  5DFR A;  4P68 A;  3FRA X;  1DIU A;  1DRB A;  4ECK A;  1J3K A;  3OCH A;  2FZH A;  3KY8 A;  3QLY A;  3SGY A;  3JWM A;  1DHJ A;  1ZDR A;  3SH2 A;  3JW5 A;  4Q6A A;  1OHK A;  4XT6 A;  4FHB A;  1RF7 A;  1DYJ A;  3QL0 A;  1RA1 A;  1DR4 A;  4XT7 A;  1DLR A;  2BLC A;  4X5J A;  5HF2 X;  3K2H A;  3TQB A;  1RX3 A;  4KEB A;  2O7P A;  1IA1 A;  3NXO A;  1D1G A;  1DR7 A;  1RX5 A;  4XT8 A;  1PD9 A;  1AI9 A;  4QLG A;  2FZI A;  3EEL A;  3GHV A;  4KJJ A;  4PST A;  3GI2 A;  3INV A;  1VDR A;  4I1N A;  2D5N A;  3CLB A;  2GD9 A;  3NXR A;  4XEC X;  3QLW A;  2W9T A;  3SRW X;  6DFR A;  2L28 A;  4IXE D;  5U27 A;  1MVS A;  3QYL A;  1AO8 A;  3KJS A;  4ELB A;  1RX7 A;  4KLX A;  1E26 A;  2C2S A;  3JWF A;  3FY8 X;  3M08 A;  4IXF X;  3NXY A;  2FZJ A;  4NX7 A;  5HT5 A;  5HSR A;  1RX8 A;  5EAJ A;  1J3J A;  8DFR A;  4M2X A;  2C2T A;  4OR7 A;  1RD7 A;  4ELE A;  4H97 A;  3DFR A;  3QGT A;  3ZPG A;  3F0B X;  3FY9 X;  4TU5 X; 
#chains in the Genus database with same CATH topology
 1IA2 A;  2P4G A;  1CZ3 A;  3FL8 A;  4KM2 A;  3HJ3 A;  1HFP A;  1DAJ A;  1DRH A;  3JVX A;  2G6V A;  3IX9 A;  2XW7 A;  4KBN A;  3FQV A;  3I8A X;  5ECC A;  1DDR A;  3FQO A;  4M6L A;  1LY4 A;  3SRQ X;  5HI6 A;  3F8Y A;  3NU0 A;  1HFR A;  4EIZ A;  1PDB A;  3SRU X;  3UM6 A;  1RX9 A;  3FRB X;  1U71 A;  1DR5 A;  1QZF A;  2D0K A;  1DF7 A;  1M7A A;  4XT4 A;  3DG8 A;  4KM0 A;  1U72 A;  3NZA X;  5HSU A;  3FQ0 A;  3FRD X;  3K45 A;  4QHV A;  3QFX A;  5E8Q A;  4M6J A;  4PDJ A;  1YHO A;  3KFY A;  3TD8 A;  3OAF A;  1DYR A;  3Q1H A;  3TQ9 A;  2W3B A;  2CD2 A;  1DRF A;  5HT4 A;  1RH3 A;  3JSU A;  3N0H A;  2LF1 A;  2W9G A;  4EIL A;  3DAU A;  1IA3 A;  4DPH A;  3SRS X;  1DR1 A;  3FRE X;  4H96 A;  4QJZ D;  5HQY A;  3VCO A;  4PTJ A;  4LEK X;  4ELF A;  1DHF A;  4ELH A;  4KJL A;  4IXG X;  3SR5 X;  1KMS A;  2INQ A;  3EEJ A;  4GH8 A;  3UM8 A;  4CD2 A;  3K47 A;  3F0Q X;  1AOE A;  3TQA A;  2BLB A;  3S7A A;  4X5F A;  1JUV A;  1S3W A;  5HVB A;  2QK8 A;  3FS6 A;  4P3R A;  1DG7 A;  3JWC A;  1DYH A;  4PSS A;  4DDR A;  5JA3 A;  1CD2 A;  3EEM A;  3QLR A;  1RE7 A;  1OHJ A;  4DPD A;  3F91 A;  3IRO A;  1PD8 A;  3ZPC A;  4PTH A;  2W3V A;  3JW3 A;  5JG0 X;  3CD2 A;  3DAT A;  3FL9 A;  5DXV A;  5FDA A;  1RA2 A;  4QLE A;  1IA4 A;  2B3Z A;  4M7V A;  1RC4 A;  4G8Z X;  2BL9 A;  4Q0D A;  2W9H A;  1BZF A;  2ANQ A;  1DRA A;  1DLS A;  1DG8 A;  3HBB A;  4HOG A;  3SAI A;  3F0V X;  3S3V A;  3SA2 A;  4XT5 A;  1U70 A;  2ITH A;  3CL9 A;  1RX2 A;  1HFQ A;  1JOL A;  3NTZ A;  5HPB A;  4KNE A;  3F8Z A;  4DFR A;  3IA5 A;  4KD7 A;  3FQC A;  1RA8 A;  2HXV A;  7DFR A;  1RX6 A;  3D84 X;  4KJK A;  4KL9 A;  2AZN A;  4XRB A;  1KMV A;  3NXV A;  1DRE A;  1TDR A;  1RB2 A;  2JYB A;  4QI9 A;  3UM5 A;  4I13 A;  4KY4 A;  1RG7 A;  3SA1 A;  3GHC A;  3QLZ A;  3RG9 A;  5HVE A;  3IRM A;  2DHF A;  3JWK A;  4LAE X;  1RA9 A;  4LAH X;  4KYA A;  5HUI A;  3FYW X;  1LY3 A;  3QLS A;  4EJ1 A;  1MVT A;  3NZD A;  4FGH A;  3JTW A;  5CCC A;  3CSE A;  4H98 A;  2OBC A;  3DRC A;  1J3I A;  4H95 A;  4M7U A;  4HOE A;  1DYI A;  3NZB X;  4M6K A;  4LAG X;  4FGG A;  4OSG A;  3K74 A;  5CC9 A;  2CIG A;  3KGY A;  3R33 A;  3QYO A;  1S3V A;  3E0B A;  1RA3 A;  2W9S A;  4Q67 A;  1DR2 A;  3NXX A;  3SRR X;  1DIS A;  4QLF A;  5ECX A;  3I3R A;  4QJC A;  3F0X X;  1DG5 A;  3IA4 A;  1DR3 A;  4XE6 X;  4ELG A;  2ZZA A;  1DDS A;  2W3W A;  3DL6 A;  3F0U X;  1JOM A;  2W3M A;  3FQZ A;  4P3Q A;  4RGC A;  3RO9 A;  2H2Q A;  1SEJ A;  3NZ9 X;  3KJR A;  3FRF X;  4X5I A;  4HA7 A;  4P66 A;  4G3M A;  4X5H A;  4KAK A;  1S3U A;  4Q0E A;  3IRN A;  2HM9 A;  5HF0 X;  1KLK A;  1S3Y A;  2DRC A;  3EX8 A;  4KFJ A;  1DHI A;  3L3R A;  2W3A A;  1RX4 A;  3EIG A;  3EEK A;  3DL5 A;  3NZC X;  4HOF A;  2KGK A;  3ROA A;  4X5G A;  1RX1 A;  1RB3 A;  3S9U A;  1LUD A;  3SQY X;  1DR6 A;  4PSY A;  2HQP A;  3M09 A;  5U26 A;  4G95 A;  3F0S X;  2ANO A;  3GYF A;  3LG4 A;  3TQ8 A;  3DGA A;  4DP3 A;  2BLA A;  3D80 A;  3QG2 A;  4KY8 A;  4EIG A;  3NXT A;  5HQZ A;  2OIP A;  3FQF A;  3NRR A;  3QL3 A;  3QLX A;  1M79 A;  4NX6 A;  3FYV X;  1BOZ A;  1VJ3 A;  1M78 A;  3NZ6 X;  4HA9 A;  3GHW A;  5DFR A;  4P68 A;  3FRA X;  1DIU A;  1DRB A;  4ECK A;  1J3K A;  3OCH A;  2FZH A;  3KY8 A;  3QLY A;  3SGY A;  3JWM A;  1DHJ A;  1ZDR A;  3SH2 A;  3JW5 A;  4Q6A A;  1OHK A;  4XT6 A;  4FHB A;  1RF7 A;  1DYJ A;  3QL0 A;  1RA1 A;  1DR4 A;  4XT7 A;  1DLR A;  2BLC A;  4X5J A;  5HF2 X;  3K2H A;  3TQB A;  1RX3 A;  4KEB A;  2O7P A;  1IA1 A;  3NXO A;  1D1G A;  1DR7 A;  1RX5 A;  4XT8 A;  1PD9 A;  1AI9 A;  4QLG A;  2FZI A;  3EEL A;  3GHV A;  4KJJ A;  4PST A;  3GI2 A;  3INV A;  1VDR A;  4I1N A;  2D5N A;  3CLB A;  2GD9 A;  3NXR A;  4XEC X;  3QLW A;  2W9T A;  3SRW X;  6DFR A;  2L28 A;  4IXE D;  5U27 A;  1MVS A;  3QYL A;  1AO8 A;  3KJS A;  4ELB A;  1RX7 A;  4KLX A;  1E26 A;  2C2S A;  3JWF A;  3FY8 X;  3M08 A;  4IXF X;  3NXY A;  2FZJ A;  4NX7 A;  5HT5 A;  5HSR A;  1RX8 A;  5EAJ A;  1J3J A;  8DFR A;  4M2X A;  2C2T A;  4OR7 A;  1RD7 A;  4ELE A;  4H97 A;  3DFR A;  3QGT A;  3ZPG A;  3F0B X;  3FY9 X;  4TU5 X; 
#chains in the Genus database with same CATH homology
 1IA2 A;  2P4G A;  1CZ3 A;  3FL8 A;  4KM2 A;  3HJ3 A;  1HFP A;  1DAJ A;  1DRH A;  3JVX A;  2G6V A;  3IX9 A;  2XW7 A;  4KBN A;  3FQV A;  3I8A X;  5ECC A;  1DDR A;  3FQO A;  4M6L A;  1LY4 A;  3SRQ X;  5HI6 A;  3F8Y A;  3NU0 A;  1HFR A;  4EIZ A;  1PDB A;  3SRU X;  3UM6 A;  1RX9 A;  3FRB X;  1U71 A;  1DR5 A;  1QZF A;  2D0K A;  1DF7 A;  1M7A A;  4XT4 A;  3DG8 A;  4KM0 A;  1U72 A;  3NZA X;  5HSU A;  3FQ0 A;  3FRD X;  3K45 A;  4QHV A;  3QFX A;  5E8Q A;  4M6J A;  4PDJ A;  1YHO A;  3KFY A;  3TD8 A;  3OAF A;  1DYR A;  3Q1H A;  3TQ9 A;  2W3B A;  2CD2 A;  1DRF A;  5HT4 A;  1RH3 A;  3JSU A;  3N0H A;  2LF1 A;  2W9G A;  4EIL A;  3DAU A;  1IA3 A;  4DPH A;  3SRS X;  1DR1 A;  3FRE X;  4H96 A;  4QJZ D;  5HQY A;  3VCO A;  4PTJ A;  4LEK X;  4ELF A;  1DHF A;  4ELH A;  4KJL A;  4IXG X;  3SR5 X;  1KMS A;  2INQ A;  3EEJ A;  4GH8 A;  3UM8 A;  4CD2 A;  3K47 A;  3F0Q X;  1AOE A;  3TQA A;  2BLB A;  3S7A A;  4X5F A;  1JUV A;  1S3W A;  5HVB A;  2QK8 A;  3FS6 A;  4P3R A;  1DG7 A;  3JWC A;  1DYH A;  4PSS A;  4DDR A;  5JA3 A;  1CD2 A;  3EEM A;  3QLR A;  1RE7 A;  1OHJ A;  4DPD A;  3F91 A;  3IRO A;  1PD8 A;  3ZPC A;  4PTH A;  2W3V A;  3JW3 A;  5JG0 X;  3CD2 A;  3DAT A;  3FL9 A;  5DXV A;  5FDA A;  1RA2 A;  4QLE A;  1IA4 A;  2B3Z A;  4M7V A;  1RC4 A;  4G8Z X;  2BL9 A;  4Q0D A;  2W9H A;  1BZF A;  2ANQ A;  1DRA A;  1DLS A;  1DG8 A;  3HBB A;  4HOG A;  3SAI A;  3F0V X;  3S3V A;  3SA2 A;  4XT5 A;  1U70 A;  2ITH A;  3CL9 A;  1RX2 A;  1HFQ A;  1JOL A;  3NTZ A;  5HPB A;  4KNE A;  3F8Z A;  4DFR A;  3IA5 A;  4KD7 A;  3FQC A;  1RA8 A;  2HXV A;  7DFR A;  1RX6 A;  3D84 X;  4KJK A;  4KL9 A;  2AZN A;  4XRB A;  1KMV A;  3NXV A;  1DRE A;  1TDR A;  1RB2 A;  2JYB A;  4QI9 A;  3UM5 A;  4I13 A;  4KY4 A;  1RG7 A;  3SA1 A;  3GHC A;  3QLZ A;  3RG9 A;  5HVE A;  3IRM A;  2DHF A;  3JWK A;  4LAE X;  1RA9 A;  4LAH X;  4KYA A;  5HUI A;  3FYW X;  1LY3 A;  3QLS A;  4EJ1 A;  1MVT A;  3NZD A;  4FGH A;  3JTW A;  5CCC A;  3CSE A;  4H98 A;  2OBC A;  3DRC A;  1J3I A;  4H95 A;  4M7U A;  4HOE A;  1DYI A;  3NZB X;  4M6K A;  4LAG X;  4FGG A;  4OSG A;  3K74 A;  5CC9 A;  2CIG A;  3KGY A;  3R33 A;  3QYO A;  1S3V A;  3E0B A;  1RA3 A;  2W9S A;  4Q67 A;  1DR2 A;  3NXX A;  3SRR X;  1DIS A;  4QLF A;  5ECX A;  3I3R A;  4QJC A;  3F0X X;  1DG5 A;  3IA4 A;  1DR3 A;  4XE6 X;  4ELG A;  2ZZA A;  1DDS A;  2W3W A;  3DL6 A;  3F0U X;  1JOM A;  2W3M A;  3FQZ A;  4P3Q A;  4RGC A;  3RO9 A;  2H2Q A;  1SEJ A;  3NZ9 X;  3KJR A;  3FRF X;  4X5I A;  4HA7 A;  4P66 A;  4G3M A;  4X5H A;  4KAK A;  1S3U A;  4Q0E A;  3IRN A;  2HM9 A;  5HF0 X;  1KLK A;  1S3Y A;  2DRC A;  3EX8 A;  4KFJ A;  1DHI A;  3L3R A;  2W3A A;  1RX4 A;  3EIG A;  3EEK A;  3DL5 A;  3NZC X;  4HOF A;  2KGK A;  3ROA A;  4X5G A;  1RX1 A;  1RB3 A;  3S9U A;  1LUD A;  3SQY X;  1DR6 A;  4PSY A;  2HQP A;  3M09 A;  5U26 A;  4G95 A;  3F0S X;  2ANO A;  3GYF A;  3LG4 A;  3TQ8 A;  3DGA A;  4DP3 A;  2BLA A;  3D80 A;  3QG2 A;  4KY8 A;  4EIG A;  3NXT A;  5HQZ A;  2OIP A;  3FQF A;  3NRR A;  3QL3 A;  3QLX A;  1M79 A;  4NX6 A;  3FYV X;  1BOZ A;  1VJ3 A;  1M78 A;  3NZ6 X;  4HA9 A;  3GHW A;  5DFR A;  4P68 A;  3FRA X;  1DIU A;  1DRB A;  4ECK A;  1J3K A;  3OCH A;  2FZH A;  3KY8 A;  3QLY A;  3SGY A;  3JWM A;  1DHJ A;  1ZDR A;  3SH2 A;  3JW5 A;  4Q6A A;  1OHK A;  4XT6 A;  4FHB A;  1RF7 A;  1DYJ A;  3QL0 A;  1RA1 A;  1DR4 A;  4XT7 A;  1DLR A;  2BLC A;  4X5J A;  5HF2 X;  3K2H A;  3TQB A;  1RX3 A;  4KEB A;  2O7P A;  1IA1 A;  3NXO A;  1D1G A;  1DR7 A;  1RX5 A;  4XT8 A;  1PD9 A;  1AI9 A;  4QLG A;  2FZI A;  3EEL A;  3GHV A;  4KJJ A;  4PST A;  3GI2 A;  3INV A;  1VDR A;  4I1N A;  2D5N A;  3CLB A;  2GD9 A;  3NXR A;  4XEC X;  3QLW A;  2W9T A;  3SRW X;  6DFR A;  2L28 A;  4IXE D;  5U27 A;  1MVS A;  3QYL A;  1AO8 A;  3KJS A;  4ELB A;  1RX7 A;  4KLX A;  1E26 A;  2C2S A;  3JWF A;  3FY8 X;  3M08 A;  4IXF X;  3NXY A;  2FZJ A;  4NX7 A;  5HT5 A;  5HSR A;  1RX8 A;  5EAJ A;  1J3J A;  8DFR A;  4M2X A;  2C2T A;  4OR7 A;  1RD7 A;  4ELE A;  4H97 A;  3DFR A;  3QGT A;  3ZPG A;  3F0B X;  3FY9 X;  4TU5 X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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