4GH8A

Crystal structure of a 'humanized' e. coli dihydrofolate reductase
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
162
structure length
162
Chain Sequence
MISLIAALAVDRVIGMENAMPWPPLPADLAWFKRNTLNKPVIMGRHTWESIPEKNRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords Dihydrofolate reductase
total genus 45
structure length 162
sequence length 162
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2012-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4gh8A00
3GHCA 3FY9X 4Q0EA 3IX9A 3HBBA 1JUVA 1DYHA 4I13A 2LF1A 1U72A 1DG8A 1SEJA 2ITHA 3FYWX 1DIUA 2H2QA 1LUDA 1PDBA 3KJSA 4XECX 4IXGX 3DAUA 3JVXA 2ANOA 1DG5A 3TQ8A 3QG2A 3FY8X 3QLZA 3E0BA 4X5FA 4XT8A 3UM6A 4EIGA 5HVBA 4LAEX 4H95A 4LEKX 3QL0A 4DFRA 1M79A 1DRAA 3ZPGA 3F0BX 1RX9A 4PTHA 1RA3A 3FRBX 3FYVX 1DHJA 1RB2A 5EAJA 4ELEA 2BLBA 4XT6A 5U27A 3FRDX 3L3RA 3DG8A 1DHIA 3M08A 1S3UA 3DL6A 2C2SA 1MVSA 3FQFA 2W9TA 5HSUA 4KAKA 1RF7A 3K47A 4DP3A 3SA2A 5HQZA 2O7PA 2D5NA 1AOEA 3QYLA 4EILA 1HFPA 4CD2A 4QJCA 3QLYA 4M2XA 3S3VA 5HF0X 2ANQA 3F0QX 1DF7A 5HQYA 4G8ZX 4M6JA 4QI9A 1RA2A 1DLSA 4M7VA 4KL9A 5HT4A 3D84X 3SR5X 3SRRX 3SH2A 1TDRA 4PDJA 3K74A 3HJ3A 2W9SA 1DR5A 2DRCA 4QLEA 1DYJA 2L28A 2BL9A 3I8AX 5U26A 4ELHA 3DFRA 3F8ZA 1DREA 4XRBA 1AO8A 5HT5A 4H98A 3NRRA 3FQVA 3GI2A 3SRWX 3DRCA 3IRNA 5ECCA 3I3RA 3QL3A 4ELBA 4NX6A 3KY8A 3SRQX 2FZHA 1IA1A 2C2TA 1QZFA 3QYOA 4I1NA 1DRFA 5E8QA 5JG0X 1LY4A 1DR6A 2FZJA 2BLAA 3R33A 3NXRA 4XT5A 1D1GA 2GD9A 2W3MA 2BLCA 1RA1A 3FL8A 4KBNA 5DFRA 3N0HA 1RD7A 3LG4A 3IA5A 4LAGX 3EEMA 3QLWA 1ZDRA 2DHFA 4HOEA 4OSGA 2XW7A 2HQPA 3EIGA 1VDRA 4TU5X 3TQAA 2AZNA 3JWCA 4M6LA 5FDAA 5HUIA 4KD7A 1DR4A 3JW5A 2ZZAA 3JW3A 4X5IA 1RX8A 3TQBA 4PSYA 4H97A 3SGYA 1VJ3A 3OCHA 1DDRA 2CIGA 5HI6A 1KLKA 5HF2X 1PD9A 3EEJA 4KY4A 4QLFA 3K2HA 1IA2A 4KEBA 4M7UA 4KJJA 4KNEA 1DR7A 2W9GA 3FQ0A 3KFYA 4EIZA 1RX3A 1DR3A 2INQA 4KYAA 1JOMA 3Q1HA 1DR1A 1S3WA 4X5JA 4XT4A 8DFRA 2W3AA 1OHJA 3SAIA 3SRSX 2OIPA 3GHVA 4QLGA 1CZ3A 5HPBA 1RX2A 1BOZA 1DG7A 3KJRA 4P66A 3JTWA 3NZAX 4KY8A 2HXVA 1DLRA 3TD8A 4DPDA 4QJZD 2OBCA 1KMVA 1MVTA 4KJKA 4IXFX 4Q67A 3NXYA 3NZDA 3CD2A 3NXOA 4G95A 3CLBA 2W9HA 1KMSA 4X5HA 3CL9A 3RG9A 1LY3A 3SQYX 3JSUA 4M6KA 1DDSA 1RX1A 4HA9A 3FQZA 1PD8A 4KM0A 3SA1A 4KLXA 3K45A 1RC4A 1DYRA 5CCCA 1AI9A 2D0KA 1YHOA 1DRHA 1DYIA 3NXXA 5HSRA 3GYFA 1E26A 3JWKA 2HM9A 1RX4A 2G6VA 3UM5A 1DISA 4Q0DA 4RGCA 3EEKA 4OR7A 3IA4A 4FGHA 3NXTA 3QLSA 1RA9A 3EELA 4FHBA 3NTZA 1IA3A 3FQOA 4Q6AA 4ELGA 1IA4A 4HA7A 3F0UX 4IXED 1U70A 3CSEA 3F0XX 3NZBX 5HVEA 2JYBA 3VCOA 3NZCX 4GH8A 5CC9A 3TQ9A 3F0VX 3DL5A 1DAJA 1RX5A 3NZ6X 2B3ZA 4LAHX 4KM2A 1RG7A 4G3MA 4PTJA 3FQCA 4PSTA 3SRUX 3FREX 2W3VA 2P4GA 4FGGA 3NXVA 3GHWA 4ELFA 1S3YA 3FRAX 1OHKA 3M09A 1DRBA 3JWMA 4H96A 4X5GA 3F91A 5JA3A 4EJ1A 4XE6X 1HFRA 5DXVA 1M78A 1RH3A 1CD2A 1RE7A 3F8YA 3RO9A 3KGYA 3D80A 3IROA 3QGTA 3DATA 3S9UA 4ECKA 2QK8A 2CD2A 3DGAA 3INVA 1DHFA 1J3JA 3OAFA 1RA8A 3ROAA 6DFRA 4KFJA 3IRMA 4P3QA 2FZIA 3JWFA 3NZ9X 3FS6A 3FL9A 3QLXA 3NU0A 1J3IA 1J3KA 2W3WA 4KJLA 3FRFX 1DR2A 4HOFA 4P3RA 7DFRA 1U71A 1RB3A 3ZPCA 4QHVA 1JOLA 3QFXA 1M7AA 4HOGA 3QLRA 4DDRA 4DPHA 2KGKA 3F0SX 4XT7A 1HFQA 5ECXA 3S7AA 1BZFA 4NX7A 4P68A 1RX7A 1S3VA 4PSSA 2W3BA 3EX8A 1RX6A 3UM8A
chains in the Genus database with same CATH superfamily
3GHCA 3FY9X 4Q0EA 3IX9A 3HBBA 1JUVA 1DYHA 4I13A 2LF1A 1U72A 1DG8A 1SEJA 2ITHA 3FYWX 1DIUA 2H2QA 1LUDA 1PDBA 3KJSA 4XECX 4IXGX 3DAUA 3JVXA 2ANOA 1DG5A 3TQ8A 3QG2A 3FY8X 3QLZA 3E0BA 4X5FA 4XT8A 3UM6A 4EIGA 5HVBA 4LAEX 4H95A 4LEKX 3QL0A 4DFRA 1M79A 1DRAA 3ZPGA 3F0BX 1RX9A 4PTHA 1RA3A 3FRBX 3FYVX 1DHJA 1RB2A 5EAJA 4ELEA 2BLBA 4XT6A 5U27A 3FRDX 3L3RA 3DG8A 1DHIA 3M08A 1S3UA 3DL6A 2C2SA 1MVSA 3FQFA 2W9TA 5HSUA 4KAKA 1RF7A 3K47A 4DP3A 3SA2A 5HQZA 2O7PA 2D5NA 1AOEA 3QYLA 4EILA 1HFPA 4CD2A 4QJCA 3QLYA 4M2XA 3S3VA 5HF0X 2ANQA 3F0QX 1DF7A 5HQYA 4G8ZX 4M6JA 4QI9A 1RA2A 1DLSA 4M7VA 4KL9A 5HT4A 3D84X 3SR5X 3SRRX 3SH2A 1TDRA 4PDJA 3K74A 3HJ3A 2W9SA 1DR5A 2DRCA 4QLEA 1DYJA 2L28A 2BL9A 3I8AX 5U26A 4ELHA 3DFRA 3F8ZA 1DREA 4XRBA 1AO8A 5HT5A 4H98A 3NRRA 3FQVA 3GI2A 3SRWX 3DRCA 3IRNA 5ECCA 3I3RA 3QL3A 4ELBA 4NX6A 3KY8A 3SRQX 2FZHA 1IA1A 2C2TA 1QZFA 3QYOA 4I1NA 1DRFA 5E8QA 5JG0X 1LY4A 1DR6A 2FZJA 2BLAA 3R33A 3NXRA 4XT5A 1D1GA 2GD9A 2W3MA 2BLCA 1RA1A 3FL8A 4KBNA 5DFRA 3N0HA 1RD7A 3LG4A 3IA5A 4LAGX 3EEMA 3QLWA 1ZDRA 2DHFA 4HOEA 4OSGA 2XW7A 2HQPA 3EIGA 1VDRA 4TU5X 3TQAA 2AZNA 3JWCA 4M6LA 5FDAA 5HUIA 4KD7A 1DR4A 3JW5A 2ZZAA 3JW3A 4X5IA 1RX8A 3TQBA 4PSYA 4H97A 3SGYA 1VJ3A 3OCHA 1DDRA 2CIGA 5HI6A 1KLKA 5HF2X 1PD9A 3EEJA 4KY4A 4QLFA 3K2HA 1IA2A 4KEBA 4M7UA 4KJJA 4KNEA 1DR7A 2W9GA 3FQ0A 3KFYA 4EIZA 1RX3A 1DR3A 2INQA 4KYAA 1JOMA 3Q1HA 1DR1A 1S3WA 4X5JA 4XT4A 8DFRA 2W3AA 1OHJA 3SAIA 3SRSX 2OIPA 3GHVA 4QLGA 1CZ3A 5HPBA 1RX2A 1BOZA 1DG7A 3KJRA 4P66A 3JTWA 3NZAX 4KY8A 2HXVA 1DLRA 3TD8A 4DPDA 4QJZD 2OBCA 1KMVA 1MVTA 4KJKA 4IXFX 4Q67A 3NXYA 3NZDA 3CD2A 3NXOA 4G95A 3CLBA 2W9HA 1KMSA 4X5HA 3CL9A 3RG9A 1LY3A 3SQYX 3JSUA 4M6KA 1DDSA 1RX1A 4HA9A 3FQZA 1PD8A 4KM0A 3SA1A 4KLXA 3K45A 1RC4A 1DYRA 5CCCA 1AI9A 2D0KA 1YHOA 1DRHA 1DYIA 3NXXA 5HSRA 3GYFA 1E26A 3JWKA 2HM9A 1RX4A 2G6VA 3UM5A 1DISA 4Q0DA 4RGCA 3EEKA 4OR7A 3IA4A 4FGHA 3NXTA 3QLSA 1RA9A 3EELA 4FHBA 3NTZA 1IA3A 3FQOA 4Q6AA 4ELGA 1IA4A 4HA7A 3F0UX 4IXED 1U70A 3CSEA 3F0XX 3NZBX 5HVEA 2JYBA 3VCOA 3NZCX 4GH8A 5CC9A 3TQ9A 3F0VX 3DL5A 1DAJA 1RX5A 3NZ6X 2B3ZA 4LAHX 4KM2A 1RG7A 4G3MA 4PTJA 3FQCA 4PSTA 3SRUX 3FREX 2W3VA 2P4GA 4FGGA 3NXVA 3GHWA 4ELFA 1S3YA 3FRAX 1OHKA 3M09A 1DRBA 3JWMA 4H96A 4X5GA 3F91A 5JA3A 4EJ1A 4XE6X 1HFRA 5DXVA 1M78A 1RH3A 1CD2A 1RE7A 3F8YA 3RO9A 3KGYA 3D80A 3IROA 3QGTA 3DATA 3S9UA 4ECKA 2QK8A 2CD2A 3DGAA 3INVA 1DHFA 1J3JA 3OAFA 1RA8A 3ROAA 6DFRA 4KFJA 3IRMA 4P3QA 2FZIA 3JWFA 3NZ9X 3FS6A 3FL9A 3QLXA 3NU0A 1J3IA 1J3KA 2W3WA 4KJLA 3FRFX 1DR2A 4HOFA 4P3RA 7DFRA 1U71A 1RB3A 3ZPCA 4QHVA 1JOLA 3QFXA 1M7AA 4HOGA 3QLRA 4DDRA 4DPHA 2KGKA 3F0SX 4XT7A 1HFQA 5ECXA 3S7AA 1BZFA 4NX7A 4P68A 1RX7A 1S3VA 4PSSA 2W3BA 3EX8A 1RX6A 3UM8A
chains in the Genus database with same CATH topology
3GHCA 3FY9X 4Q0EA 3IX9A 3HBBA 1JUVA 1DYHA 4I13A 2LF1A 1U72A 1DG8A 1SEJA 2ITHA 3FYWX 1DIUA 2H2QA 1LUDA 1PDBA 3KJSA 4XECX 4IXGX 3DAUA 3JVXA 2ANOA 1DG5A 3TQ8A 3QG2A 3FY8X 3QLZA 3E0BA 4X5FA 4XT8A 3UM6A 4EIGA 5HVBA 4LAEX 4H95A 4LEKX 3QL0A 4DFRA 1M79A 1DRAA 3ZPGA 3F0BX 1RX9A 4PTHA 1RA3A 3FRBX 3FYVX 1DHJA 1RB2A 5EAJA 4ELEA 2BLBA 4XT6A 5U27A 3FRDX 3L3RA 3DG8A 1DHIA 3M08A 1S3UA 3DL6A 2C2SA 1MVSA 3FQFA 2W9TA 5HSUA 4KAKA 1RF7A 3K47A 4DP3A 3SA2A 5HQZA 2O7PA 2D5NA 1AOEA 3QYLA 4EILA 1HFPA 4CD2A 4QJCA 3QLYA 4M2XA 3S3VA 5HF0X 2ANQA 3F0QX 1DF7A 5HQYA 4G8ZX 4M6JA 4QI9A 1RA2A 1DLSA 4M7VA 4KL9A 5HT4A 3D84X 3SR5X 3SRRX 3SH2A 1TDRA 4PDJA 3K74A 3HJ3A 2W9SA 1DR5A 2DRCA 4QLEA 1DYJA 2L28A 2BL9A 3I8AX 5U26A 4ELHA 3DFRA 3F8ZA 1DREA 4XRBA 1AO8A 5HT5A 4H98A 3NRRA 3FQVA 3GI2A 3SRWX 3DRCA 3IRNA 5ECCA 3I3RA 3QL3A 4ELBA 4NX6A 3KY8A 3SRQX 2FZHA 1IA1A 2C2TA 1QZFA 3QYOA 4I1NA 1DRFA 5E8QA 5JG0X 1LY4A 1DR6A 2FZJA 2BLAA 3R33A 3NXRA 4XT5A 1D1GA 2GD9A 2W3MA 2BLCA 1RA1A 3FL8A 4KBNA 5DFRA 3N0HA 1RD7A 3LG4A 3IA5A 4LAGX 3EEMA 3QLWA 1ZDRA 2DHFA 4HOEA 4OSGA 2XW7A 2HQPA 3EIGA 1VDRA 4TU5X 3TQAA 2AZNA 3JWCA 4M6LA 5FDAA 5HUIA 4KD7A 1DR4A 3JW5A 2ZZAA 3JW3A 4X5IA 1RX8A 3TQBA 4PSYA 4H97A 3SGYA 1VJ3A 3OCHA 1DDRA 2CIGA 5HI6A 1KLKA 5HF2X 1PD9A 3EEJA 4KY4A 4QLFA 3K2HA 1IA2A 4KEBA 4M7UA 4KJJA 4KNEA 1DR7A 2W9GA 3FQ0A 3KFYA 4EIZA 1RX3A 1DR3A 2INQA 4KYAA 1JOMA 3Q1HA 1DR1A 1S3WA 4X5JA 4XT4A 8DFRA 2W3AA 1OHJA 3SAIA 3SRSX 2OIPA 3GHVA 4QLGA 1CZ3A 5HPBA 1RX2A 1BOZA 1DG7A 3KJRA 4P66A 3JTWA 3NZAX 4KY8A 2HXVA 1DLRA 3TD8A 4DPDA 4QJZD 2OBCA 1KMVA 1MVTA 4KJKA 4IXFX 4Q67A 3NXYA 3NZDA 3CD2A 3NXOA 4G95A 3CLBA 2W9HA 1KMSA 4X5HA 3CL9A 3RG9A 1LY3A 3SQYX 3JSUA 4M6KA 1DDSA 1RX1A 4HA9A 3FQZA 1PD8A 4KM0A 3SA1A 4KLXA 3K45A 1RC4A 1DYRA 5CCCA 1AI9A 2D0KA 1YHOA 1DRHA 1DYIA 3NXXA 5HSRA 3GYFA 1E26A 3JWKA 2HM9A 1RX4A 2G6VA 3UM5A 1DISA 4Q0DA 4RGCA 3EEKA 4OR7A 3IA4A 4FGHA 3NXTA 3QLSA 1RA9A 3EELA 4FHBA 3NTZA 1IA3A 3FQOA 4Q6AA 4ELGA 1IA4A 4HA7A 3F0UX 4IXED 1U70A 3CSEA 3F0XX 3NZBX 5HVEA 2JYBA 3VCOA 3NZCX 4GH8A 5CC9A 3TQ9A 3F0VX 3DL5A 1DAJA 1RX5A 3NZ6X 2B3ZA 4LAHX 4KM2A 1RG7A 4G3MA 4PTJA 3FQCA 4PSTA 3SRUX 3FREX 2W3VA 2P4GA 4FGGA 3NXVA 3GHWA 4ELFA 1S3YA 3FRAX 1OHKA 3M09A 1DRBA 3JWMA 4H96A 4X5GA 3F91A 5JA3A 4EJ1A 4XE6X 1HFRA 5DXVA 1M78A 1RH3A 1CD2A 1RE7A 3F8YA 3RO9A 3KGYA 3D80A 3IROA 3QGTA 3DATA 3S9UA 4ECKA 2QK8A 2CD2A 3DGAA 3INVA 1DHFA 1J3JA 3OAFA 1RA8A 3ROAA 6DFRA 4KFJA 3IRMA 4P3QA 2FZIA 3JWFA 3NZ9X 3FS6A 3FL9A 3QLXA 3NU0A 1J3IA 1J3KA 2W3WA 4KJLA 3FRFX 1DR2A 4HOFA 4P3RA 7DFRA 1U71A 1RB3A 3ZPCA 4QHVA 1JOLA 3QFXA 1M7AA 4HOGA 3QLRA 4DDRA 4DPHA 2KGKA 3F0SX 4XT7A 1HFQA 5ECXA 3S7AA 1BZFA 4NX7A 4P68A 1RX7A 1S3VA 4PSSA 2W3BA 3EX8A 1RX6A 3UM8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GHC A;  3FY9 X;  4Q0E A;  3IX9 A;  3HBB A;  1JUV A;  1DYH A;  4I13 A;  2LF1 A;  1U72 A;  1DG8 A;  1SEJ A;  2ITH A;  3FYW X;  1DIU A;  2H2Q A;  1LUD A;  1PDB A;  3KJS A;  4XEC X;  4IXG X;  3DAU A;  3JVX A;  2ANO A;  1DG5 A;  3TQ8 A;  3QG2 A;  3FY8 X;  3QLZ A;  3E0B A;  4X5F A;  4XT8 A;  3UM6 A;  4EIG A;  5HVB A;  4LAE X;  4H95 A;  4LEK X;  3QL0 A;  4DFR A;  1M79 A;  1DRA A;  3ZPG A;  3F0B X;  1RX9 A;  4PTH A;  1RA3 A;  3FRB X;  3FYV X;  1DHJ A;  1RB2 A;  5EAJ A;  4ELE A;  2BLB A;  4XT6 A;  5U27 A;  3FRD X;  3L3R A;  3DG8 A;  1DHI A;  3M08 A;  1S3U A;  3DL6 A;  2C2S A;  1MVS A;  3FQF A;  2W9T A;  5HSU A;  4KAK A;  1RF7 A;  3K47 A;  4DP3 A;  3SA2 A;  5HQZ A;  2O7P A;  2D5N A;  1AOE A;  3QYL A;  4EIL A;  1HFP A;  4CD2 A;  4QJC A;  3QLY A;  4M2X A;  3S3V A;  5HF0 X;  2ANQ A;  3F0Q X;  1DF7 A;  5HQY A;  4G8Z X;  4M6J A;  4QI9 A;  1RA2 A;  1DLS A;  4M7V A;  4KL9 A;  5HT4 A;  3D84 X;  3SR5 X;  3SRR X;  3SH2 A;  1TDR A;  4PDJ A;  3K74 A;  3HJ3 A;  2W9S A;  1DR5 A;  2DRC A;  4QLE A;  1DYJ A;  2L28 A;  2BL9 A;  3I8A X;  5U26 A;  4ELH A;  3DFR A;  3F8Z A;  1DRE A;  4XRB A;  1AO8 A;  5HT5 A;  4H98 A;  3NRR A;  3FQV A;  3GI2 A;  3SRW X;  3DRC A;  3IRN A;  5ECC A;  3I3R A;  3QL3 A;  4ELB A;  4NX6 A;  3KY8 A;  3SRQ X;  2FZH A;  1IA1 A;  2C2T A;  1QZF A;  3QYO A;  4I1N A;  1DRF A;  5E8Q A;  5JG0 X;  1LY4 A;  1DR6 A;  2FZJ A;  2BLA A;  3R33 A;  3NXR A;  4XT5 A;  1D1G A;  2GD9 A;  2W3M A;  2BLC A;  1RA1 A;  3FL8 A;  4KBN A;  5DFR A;  3N0H A;  1RD7 A;  3LG4 A;  3IA5 A;  4LAG X;  3EEM A;  3QLW A;  1ZDR A;  2DHF A;  4HOE A;  4OSG A;  2XW7 A;  2HQP A;  3EIG A;  1VDR A;  4TU5 X;  3TQA A;  2AZN A;  3JWC A;  4M6L A;  5FDA A;  5HUI A;  4KD7 A;  1DR4 A;  3JW5 A;  2ZZA A;  3JW3 A;  4X5I A;  1RX8 A;  3TQB A;  4PSY A;  4H97 A;  3SGY A;  1VJ3 A;  3OCH A;  1DDR A;  2CIG A;  5HI6 A;  1KLK A;  5HF2 X;  1PD9 A;  3EEJ A;  4KY4 A;  4QLF A;  3K2H A;  1IA2 A;  4KEB A;  4M7U A;  4KJJ A;  4KNE A;  1DR7 A;  2W9G A;  3FQ0 A;  3KFY A;  4EIZ A;  1RX3 A;  1DR3 A;  2INQ A;  4KYA A;  1JOM A;  3Q1H A;  1DR1 A;  1S3W A;  4X5J A;  4XT4 A;  8DFR A;  2W3A A;  1OHJ A;  3SAI A;  3SRS X;  2OIP A;  3GHV A;  4QLG A;  1CZ3 A;  5HPB A;  1RX2 A;  1BOZ A;  1DG7 A;  3KJR A;  4P66 A;  3JTW A;  3NZA X;  4KY8 A;  2HXV A;  1DLR A;  3TD8 A;  4DPD A;  4QJZ D;  2OBC A;  1KMV A;  1MVT A;  4KJK A;  4IXF X;  4Q67 A;  3NXY A;  3NZD A;  3CD2 A;  3NXO A;  4G95 A;  3CLB A;  2W9H A;  1KMS A;  4X5H A;  3CL9 A;  3RG9 A;  1LY3 A;  3SQY X;  3JSU A;  4M6K A;  1DDS A;  1RX1 A;  4HA9 A;  3FQZ A;  1PD8 A;  4KM0 A;  3SA1 A;  4KLX A;  3K45 A;  1RC4 A;  1DYR A;  5CCC A;  1AI9 A;  2D0K A;  1YHO A;  1DRH A;  1DYI A;  3NXX A;  5HSR A;  3GYF A;  1E26 A;  3JWK A;  2HM9 A;  1RX4 A;  2G6V A;  3UM5 A;  1DIS A;  4Q0D A;  4RGC A;  3EEK A;  4OR7 A;  3IA4 A;  4FGH A;  3NXT A;  3QLS A;  1RA9 A;  3EEL A;  4FHB A;  3NTZ A;  1IA3 A;  3FQO A;  4Q6A A;  4ELG A;  1IA4 A;  4HA7 A;  3F0U X;  4IXE D;  1U70 A;  3CSE A;  3F0X X;  3NZB X;  5HVE A;  2JYB A;  3VCO A;  3NZC X;  4GH8 A;  5CC9 A;  3TQ9 A;  3F0V X;  3DL5 A;  1DAJ A;  1RX5 A;  3NZ6 X;  2B3Z A;  4LAH X;  4KM2 A;  1RG7 A;  4G3M A;  4PTJ A;  3FQC A;  4PST A;  3SRU X;  3FRE X;  2W3V A;  2P4G A;  4FGG A;  3NXV A;  3GHW A;  4ELF A;  1S3Y A;  3FRA X;  1OHK A;  3M09 A;  1DRB A;  3JWM A;  4H96 A;  4X5G A;  3F91 A;  5JA3 A;  4EJ1 A;  4XE6 X;  1HFR A;  5DXV A;  1M78 A;  1RH3 A;  1CD2 A;  1RE7 A;  3F8Y A;  3RO9 A;  3KGY A;  3D80 A;  3IRO A;  3QGT A;  3DAT A;  3S9U A;  4ECK A;  2QK8 A;  2CD2 A;  3DGA A;  3INV A;  1DHF A;  1J3J A;  3OAF A;  1RA8 A;  3ROA A;  6DFR A;  4KFJ A;  3IRM A;  4P3Q A;  2FZI A;  3JWF A;  3NZ9 X;  3FS6 A;  3FL9 A;  3QLX A;  3NU0 A;  1J3I A;  1J3K A;  2W3W A;  4KJL A;  3FRF X;  1DR2 A;  4HOF A;  4P3R A;  7DFR A;  1U71 A;  1RB3 A;  3ZPC A;  4QHV A;  1JOL A;  3QFX A;  1M7A A;  4HOG A;  3QLR A;  4DDR A;  4DPH A;  2KGK A;  3F0S X;  4XT7 A;  1HFQ A;  5ECX A;  3S7A A;  1BZF A;  4NX7 A;  4P68 A;  1RX7 A;  1S3V A;  4PSS A;  2W3B A;  3EX8 A;  1RX6 A;  3UM8 A; 
#chains in the Genus database with same CATH topology
 3GHC A;  3FY9 X;  4Q0E A;  3IX9 A;  3HBB A;  1JUV A;  1DYH A;  4I13 A;  2LF1 A;  1U72 A;  1DG8 A;  1SEJ A;  2ITH A;  3FYW X;  1DIU A;  2H2Q A;  1LUD A;  1PDB A;  3KJS A;  4XEC X;  4IXG X;  3DAU A;  3JVX A;  2ANO A;  1DG5 A;  3TQ8 A;  3QG2 A;  3FY8 X;  3QLZ A;  3E0B A;  4X5F A;  4XT8 A;  3UM6 A;  4EIG A;  5HVB A;  4LAE X;  4H95 A;  4LEK X;  3QL0 A;  4DFR A;  1M79 A;  1DRA A;  3ZPG A;  3F0B X;  1RX9 A;  4PTH A;  1RA3 A;  3FRB X;  3FYV X;  1DHJ A;  1RB2 A;  5EAJ A;  4ELE A;  2BLB A;  4XT6 A;  5U27 A;  3FRD X;  3L3R A;  3DG8 A;  1DHI A;  3M08 A;  1S3U A;  3DL6 A;  2C2S A;  1MVS A;  3FQF A;  2W9T A;  5HSU A;  4KAK A;  1RF7 A;  3K47 A;  4DP3 A;  3SA2 A;  5HQZ A;  2O7P A;  2D5N A;  1AOE A;  3QYL A;  4EIL A;  1HFP A;  4CD2 A;  4QJC A;  3QLY A;  4M2X A;  3S3V A;  5HF0 X;  2ANQ A;  3F0Q X;  1DF7 A;  5HQY A;  4G8Z X;  4M6J A;  4QI9 A;  1RA2 A;  1DLS A;  4M7V A;  4KL9 A;  5HT4 A;  3D84 X;  3SR5 X;  3SRR X;  3SH2 A;  1TDR A;  4PDJ A;  3K74 A;  3HJ3 A;  2W9S A;  1DR5 A;  2DRC A;  4QLE A;  1DYJ A;  2L28 A;  2BL9 A;  3I8A X;  5U26 A;  4ELH A;  3DFR A;  3F8Z A;  1DRE A;  4XRB A;  1AO8 A;  5HT5 A;  4H98 A;  3NRR A;  3FQV A;  3GI2 A;  3SRW X;  3DRC A;  3IRN A;  5ECC A;  3I3R A;  3QL3 A;  4ELB A;  4NX6 A;  3KY8 A;  3SRQ X;  2FZH A;  1IA1 A;  2C2T A;  1QZF A;  3QYO A;  4I1N A;  1DRF A;  5E8Q A;  5JG0 X;  1LY4 A;  1DR6 A;  2FZJ A;  2BLA A;  3R33 A;  3NXR A;  4XT5 A;  1D1G A;  2GD9 A;  2W3M A;  2BLC A;  1RA1 A;  3FL8 A;  4KBN A;  5DFR A;  3N0H A;  1RD7 A;  3LG4 A;  3IA5 A;  4LAG X;  3EEM A;  3QLW A;  1ZDR A;  2DHF A;  4HOE A;  4OSG A;  2XW7 A;  2HQP A;  3EIG A;  1VDR A;  4TU5 X;  3TQA A;  2AZN A;  3JWC A;  4M6L A;  5FDA A;  5HUI A;  4KD7 A;  1DR4 A;  3JW5 A;  2ZZA A;  3JW3 A;  4X5I A;  1RX8 A;  3TQB A;  4PSY A;  4H97 A;  3SGY A;  1VJ3 A;  3OCH A;  1DDR A;  2CIG A;  5HI6 A;  1KLK A;  5HF2 X;  1PD9 A;  3EEJ A;  4KY4 A;  4QLF A;  3K2H A;  1IA2 A;  4KEB A;  4M7U A;  4KJJ A;  4KNE A;  1DR7 A;  2W9G A;  3FQ0 A;  3KFY A;  4EIZ A;  1RX3 A;  1DR3 A;  2INQ A;  4KYA A;  1JOM A;  3Q1H A;  1DR1 A;  1S3W A;  4X5J A;  4XT4 A;  8DFR A;  2W3A A;  1OHJ A;  3SAI A;  3SRS X;  2OIP A;  3GHV A;  4QLG A;  1CZ3 A;  5HPB A;  1RX2 A;  1BOZ A;  1DG7 A;  3KJR A;  4P66 A;  3JTW A;  3NZA X;  4KY8 A;  2HXV A;  1DLR A;  3TD8 A;  4DPD A;  4QJZ D;  2OBC A;  1KMV A;  1MVT A;  4KJK A;  4IXF X;  4Q67 A;  3NXY A;  3NZD A;  3CD2 A;  3NXO A;  4G95 A;  3CLB A;  2W9H A;  1KMS A;  4X5H A;  3CL9 A;  3RG9 A;  1LY3 A;  3SQY X;  3JSU A;  4M6K A;  1DDS A;  1RX1 A;  4HA9 A;  3FQZ A;  1PD8 A;  4KM0 A;  3SA1 A;  4KLX A;  3K45 A;  1RC4 A;  1DYR A;  5CCC A;  1AI9 A;  2D0K A;  1YHO A;  1DRH A;  1DYI A;  3NXX A;  5HSR A;  3GYF A;  1E26 A;  3JWK A;  2HM9 A;  1RX4 A;  2G6V A;  3UM5 A;  1DIS A;  4Q0D A;  4RGC A;  3EEK A;  4OR7 A;  3IA4 A;  4FGH A;  3NXT A;  3QLS A;  1RA9 A;  3EEL A;  4FHB A;  3NTZ A;  1IA3 A;  3FQO A;  4Q6A A;  4ELG A;  1IA4 A;  4HA7 A;  3F0U X;  4IXE D;  1U70 A;  3CSE A;  3F0X X;  3NZB X;  5HVE A;  2JYB A;  3VCO A;  3NZC X;  4GH8 A;  5CC9 A;  3TQ9 A;  3F0V X;  3DL5 A;  1DAJ A;  1RX5 A;  3NZ6 X;  2B3Z A;  4LAH X;  4KM2 A;  1RG7 A;  4G3M A;  4PTJ A;  3FQC A;  4PST A;  3SRU X;  3FRE X;  2W3V A;  2P4G A;  4FGG A;  3NXV A;  3GHW A;  4ELF A;  1S3Y A;  3FRA X;  1OHK A;  3M09 A;  1DRB A;  3JWM A;  4H96 A;  4X5G A;  3F91 A;  5JA3 A;  4EJ1 A;  4XE6 X;  1HFR A;  5DXV A;  1M78 A;  1RH3 A;  1CD2 A;  1RE7 A;  3F8Y A;  3RO9 A;  3KGY A;  3D80 A;  3IRO A;  3QGT A;  3DAT A;  3S9U A;  4ECK A;  2QK8 A;  2CD2 A;  3DGA A;  3INV A;  1DHF A;  1J3J A;  3OAF A;  1RA8 A;  3ROA A;  6DFR A;  4KFJ A;  3IRM A;  4P3Q A;  2FZI A;  3JWF A;  3NZ9 X;  3FS6 A;  3FL9 A;  3QLX A;  3NU0 A;  1J3I A;  1J3K A;  2W3W A;  4KJL A;  3FRF X;  1DR2 A;  4HOF A;  4P3R A;  7DFR A;  1U71 A;  1RB3 A;  3ZPC A;  4QHV A;  1JOL A;  3QFX A;  1M7A A;  4HOG A;  3QLR A;  4DDR A;  4DPH A;  2KGK A;  3F0S X;  4XT7 A;  1HFQ A;  5ECX A;  3S7A A;  1BZF A;  4NX7 A;  4P68 A;  1RX7 A;  1S3V A;  4PSS A;  2W3B A;  3EX8 A;  1RX6 A;  3UM8 A; 
#chains in the Genus database with same CATH homology
 3GHC A;  3FY9 X;  4Q0E A;  3IX9 A;  3HBB A;  1JUV A;  1DYH A;  4I13 A;  2LF1 A;  1U72 A;  1DG8 A;  1SEJ A;  2ITH A;  3FYW X;  1DIU A;  2H2Q A;  1LUD A;  1PDB A;  3KJS A;  4XEC X;  4IXG X;  3DAU A;  3JVX A;  2ANO A;  1DG5 A;  3TQ8 A;  3QG2 A;  3FY8 X;  3QLZ A;  3E0B A;  4X5F A;  4XT8 A;  3UM6 A;  4EIG A;  5HVB A;  4LAE X;  4H95 A;  4LEK X;  3QL0 A;  4DFR A;  1M79 A;  1DRA A;  3ZPG A;  3F0B X;  1RX9 A;  4PTH A;  1RA3 A;  3FRB X;  3FYV X;  1DHJ A;  1RB2 A;  5EAJ A;  4ELE A;  2BLB A;  4XT6 A;  5U27 A;  3FRD X;  3L3R A;  3DG8 A;  1DHI A;  3M08 A;  1S3U A;  3DL6 A;  2C2S A;  1MVS A;  3FQF A;  2W9T A;  5HSU A;  4KAK A;  1RF7 A;  3K47 A;  4DP3 A;  3SA2 A;  5HQZ A;  2O7P A;  2D5N A;  1AOE A;  3QYL A;  4EIL A;  1HFP A;  4CD2 A;  4QJC A;  3QLY A;  4M2X A;  3S3V A;  5HF0 X;  2ANQ A;  3F0Q X;  1DF7 A;  5HQY A;  4G8Z X;  4M6J A;  4QI9 A;  1RA2 A;  1DLS A;  4M7V A;  4KL9 A;  5HT4 A;  3D84 X;  3SR5 X;  3SRR X;  3SH2 A;  1TDR A;  4PDJ A;  3K74 A;  3HJ3 A;  2W9S A;  1DR5 A;  2DRC A;  4QLE A;  1DYJ A;  2L28 A;  2BL9 A;  3I8A X;  5U26 A;  4ELH A;  3DFR A;  3F8Z A;  1DRE A;  4XRB A;  1AO8 A;  5HT5 A;  4H98 A;  3NRR A;  3FQV A;  3GI2 A;  3SRW X;  3DRC A;  3IRN A;  5ECC A;  3I3R A;  3QL3 A;  4ELB A;  4NX6 A;  3KY8 A;  3SRQ X;  2FZH A;  1IA1 A;  2C2T A;  1QZF A;  3QYO A;  4I1N A;  1DRF A;  5E8Q A;  5JG0 X;  1LY4 A;  1DR6 A;  2FZJ A;  2BLA A;  3R33 A;  3NXR A;  4XT5 A;  1D1G A;  2GD9 A;  2W3M A;  2BLC A;  1RA1 A;  3FL8 A;  4KBN A;  5DFR A;  3N0H A;  1RD7 A;  3LG4 A;  3IA5 A;  4LAG X;  3EEM A;  3QLW A;  1ZDR A;  2DHF A;  4HOE A;  4OSG A;  2XW7 A;  2HQP A;  3EIG A;  1VDR A;  4TU5 X;  3TQA A;  2AZN A;  3JWC A;  4M6L A;  5FDA A;  5HUI A;  4KD7 A;  1DR4 A;  3JW5 A;  2ZZA A;  3JW3 A;  4X5I A;  1RX8 A;  3TQB A;  4PSY A;  4H97 A;  3SGY A;  1VJ3 A;  3OCH A;  1DDR A;  2CIG A;  5HI6 A;  1KLK A;  5HF2 X;  1PD9 A;  3EEJ A;  4KY4 A;  4QLF A;  3K2H A;  1IA2 A;  4KEB A;  4M7U A;  4KJJ A;  4KNE A;  1DR7 A;  2W9G A;  3FQ0 A;  3KFY A;  4EIZ A;  1RX3 A;  1DR3 A;  2INQ A;  4KYA A;  1JOM A;  3Q1H A;  1DR1 A;  1S3W A;  4X5J A;  4XT4 A;  8DFR A;  2W3A A;  1OHJ A;  3SAI A;  3SRS X;  2OIP A;  3GHV A;  4QLG A;  1CZ3 A;  5HPB A;  1RX2 A;  1BOZ A;  1DG7 A;  3KJR A;  4P66 A;  3JTW A;  3NZA X;  4KY8 A;  2HXV A;  1DLR A;  3TD8 A;  4DPD A;  4QJZ D;  2OBC A;  1KMV A;  1MVT A;  4KJK A;  4IXF X;  4Q67 A;  3NXY A;  3NZD A;  3CD2 A;  3NXO A;  4G95 A;  3CLB A;  2W9H A;  1KMS A;  4X5H A;  3CL9 A;  3RG9 A;  1LY3 A;  3SQY X;  3JSU A;  4M6K A;  1DDS A;  1RX1 A;  4HA9 A;  3FQZ A;  1PD8 A;  4KM0 A;  3SA1 A;  4KLX A;  3K45 A;  1RC4 A;  1DYR A;  5CCC A;  1AI9 A;  2D0K A;  1YHO A;  1DRH A;  1DYI A;  3NXX A;  5HSR A;  3GYF A;  1E26 A;  3JWK A;  2HM9 A;  1RX4 A;  2G6V A;  3UM5 A;  1DIS A;  4Q0D A;  4RGC A;  3EEK A;  4OR7 A;  3IA4 A;  4FGH A;  3NXT A;  3QLS A;  1RA9 A;  3EEL A;  4FHB A;  3NTZ A;  1IA3 A;  3FQO A;  4Q6A A;  4ELG A;  1IA4 A;  4HA7 A;  3F0U X;  4IXE D;  1U70 A;  3CSE A;  3F0X X;  3NZB X;  5HVE A;  2JYB A;  3VCO A;  3NZC X;  4GH8 A;  5CC9 A;  3TQ9 A;  3F0V X;  3DL5 A;  1DAJ A;  1RX5 A;  3NZ6 X;  2B3Z A;  4LAH X;  4KM2 A;  1RG7 A;  4G3M A;  4PTJ A;  3FQC A;  4PST A;  3SRU X;  3FRE X;  2W3V A;  2P4G A;  4FGG A;  3NXV A;  3GHW A;  4ELF A;  1S3Y A;  3FRA X;  1OHK A;  3M09 A;  1DRB A;  3JWM A;  4H96 A;  4X5G A;  3F91 A;  5JA3 A;  4EJ1 A;  4XE6 X;  1HFR A;  5DXV A;  1M78 A;  1RH3 A;  1CD2 A;  1RE7 A;  3F8Y A;  3RO9 A;  3KGY A;  3D80 A;  3IRO A;  3QGT A;  3DAT A;  3S9U A;  4ECK A;  2QK8 A;  2CD2 A;  3DGA A;  3INV A;  1DHF A;  1J3J A;  3OAF A;  1RA8 A;  3ROA A;  6DFR A;  4KFJ A;  3IRM A;  4P3Q A;  2FZI A;  3JWF A;  3NZ9 X;  3FS6 A;  3FL9 A;  3QLX A;  3NU0 A;  1J3I A;  1J3K A;  2W3W A;  4KJL A;  3FRF X;  1DR2 A;  4HOF A;  4P3R A;  7DFR A;  1U71 A;  1RB3 A;  3ZPC A;  4QHV A;  1JOL A;  3QFX A;  1M7A A;  4HOG A;  3QLR A;  4DDR A;  4DPH A;  2KGK A;  3F0S X;  4XT7 A;  1HFQ A;  5ECX A;  3S7A A;  1BZF A;  4NX7 A;  4P68 A;  1RX7 A;  1S3V A;  4PSS A;  2W3B A;  3EX8 A;  1RX6 A;  3UM8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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