4H96A

Candida albicans dihydrofolate reductase complexed with nadph and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (ucp1018)
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
189
structure length
189
Chain Sequence
PNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWESIPQKFRPLPDRLNIILSRSYENEIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNELINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQPKSELQKFVGDTVLEDDIKEGDFTYNYTLWTRK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Candida albicans
molecule keywords Dihydrofolate Reductase
total genus 46
structure length 189
sequence length 189
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2012-09-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4h96A00
1DAJA 3DL6A 1IA3A 2ZZAA 1KMVA 3SH2A 3NZCX 5ECCA 1DYJA 3FRAX 1DHJA 3K45A 2KGKA 4XT7A 4DPDA 1RX3A 3F8ZA 2W9SA 1IA2A 1RA3A 4XE6X 3D80A 4X5IA 3K74A 5CC9A 3M08A 1U70A 3CSEA 3QLSA 4KL9A 1HFPA 4KM0A 4HA7A 1DDSA 3KJSA 3ROAA 3NZBX 4ELGA 4QJCA 2D0KA 3FRDX 4IXGX 1RB3A 3QYLA 3SA2A 1J3JA 3QG2A 2GD9A 2P4GA 5U27A 4P68A 5EAJA 3QGTA 1KLKA 4Q0DA 2CD2A 3IA4A 3FQOA 1RH3A 2DHFA 3M09A 1RX5A 3TQ9A 3QFXA 3N0HA 3JWKA 2W3BA 4X5GA 3NU0A 4KBNA 3TQAA 4Q0EA 2ANQA 3SRSX 5ECXA 4EJ1A 2HM9A 3VCOA 3HJ3A 3DRCA 3QLWA 3NZ9X 4PSTA 1DRAA 4GH8A 3TQ8A 4PTJA 1DIUA 3GHCA 4RGCA 2DRCA 4KAKA 2FZHA 3F91A 1DR1A 4QJZD 4PTHA 4OR7A 3NXOA 3S3VA 2W3MA 3IX9A 5JG0X 1S3YA 2LF1A 3TD8A 3EIGA 3FRFX 5JA3A 3NXXA 3KJRA 4XT6A 1PD8A 1JOMA 3I3RA 3FQCA 1MVSA 3D84X 4H96A 1DG7A 2BLBA 1RA9A 3RO9A 3NZDA 3NXYA 4DP3A 3F0QX 1RX8A 3IRMA 3EX8A 4XRBA 3UM8A 3CLBA 4FGHA 4ELEA 4X5HA 3NXVA 1RE7A 4EIZA 1DR7A 4LAGX 3ZPGA 3SRWX 3KY8A 1DG8A 4G8ZX 3SRUX 1DF7A 3FQ0A 4IXED 1MVTA 4KLXA 3E0BA 3QLXA 3F0XX 3QL3A 4HOFA 4H98A 4LAEX 3F8YA 3GYFA 3F0VX 2FZJA 1DLRA 1DREA 3SQYX 1M7AA 2BLCA 2W3VA 2C2SA 3JW3A 2G6VA 3FL8A 4OSGA 3IA5A 1QZFA 3FREX 3TQBA 1IA1A 2JYBA 4CD2A 2W9GA 4I13A 2B3ZA 4H97A 3CL9A 4X5JA 1DG5A 3RG9A 1HFRA 1S3UA 1HFQA 4DPHA 4KY4A 4KY8A 5U26A 3NZ6X 7DFRA 2AZNA 4FGGA 1BOZA 3JVXA 3R33A 3IRNA 4M2XA 1U72A 3JWCA 1OHJA 3K2HA 3JTWA 1CD2A 4QHVA 1CZ3A 4LEKX 5DFRA 4ELHA 1RX6A 1DYRA 1DRFA 1S3VA 1RA1A 1PDBA 3FRBX 4XT4A 3QYOA 4G95A 5HF0X 4G3MA 4M6LA 1E26A 1RF7A 5HT5A 3FYWX 2HQPA 4QLFA 3QLZA 4HOEA 1AO8A 2BLAA 2INQA 3EEMA 4Q6AA 4DDRA 5HSUA 4PSSA 1DDRA 1VDRA 3SAIA 4KJKA 4KYAA 2W9TA 4DFRA 1DRHA 3QLYA 4PDJA 4P66A 2O7PA 4I1NA 1JUVA 3K47A 5CCCA 1DYHA 3FQFA 4ELFA 4KNEA 1PD9A 4KFJA 1DYIA 5HSRA 5HT4A 1DLSA 3F0BX 2CIGA 3ZPCA 1LY4A 4M7VA 5HVEA 2XW7A 3F0SX 4Q67A 1TDRA 3NZAX 3CD2A 3SGYA 4HOGA 3FL9A 1VJ3A 3GHWA 5HF2X 3DL5A 5DXVA 6DFRA 4KJJA 3UM6A 2QK8A 3INVA 3KFYA 1RB2A 1U71A 5FDAA 4KM2A 1IA4A 4KD7A 4P3RA 4LAHX 3EEKA 4QLEA 3JSUA 3SRQX 4NX7A 2L28A 3EELA 3FQVA 4FHBA 3GI2A 4QI9A 3NTZA 4TU5X 1DR6A 3DATA 1DHFA 2C2TA 3EEJA 3DAUA 2ANOA 1DR3A 3HBBA 4XECX 3SRRX 1RA2A 5HUIA 3OCHA 1YHOA 2D5NA 3JWFA 3FYVX 3FS6A 4EIGA 3S7AA 4XT8A 3SA1A 1DISA 4M7UA 3FY8X 1RA8A 1OHKA 1RD7A 1D1GA 3NXTA 2W9HA 1RX2A 2FZIA 2W3AA 1JOLA 1DRBA 1LUDA 3Q1HA 4P3QA 3GHVA 3DG8A 1M78A 5E8QA 2W3WA 3JW5A 3JWMA 1BZFA 1RX9A 5HVBA 1DR5A 3I8AX 4IXFX 4M6KA 3L3RA 3DGAA 1AI9A 2ITHA 2H2QA 3DFRA 5HI6A 4KJLA 1M79A 4PSYA 4HA9A 1RG7A 3QL0A 3UM5A 1LY3A 4KEBA 1RX7A 1SEJA 4ELBA 5HQZA 1KMSA 2OIPA 5HPBA 1RX4A 4M6JA 1S3WA 4QLGA 2HXVA 3QLRA 1AOEA 4ECKA 2OBCA 4XT5A 3SR5X 1RX1A 3KGYA 8DFRA 1J3IA 3FQZA 3NXRA 3S9UA 2BL9A 3OAFA 5HQYA 3IROA 1DR4A 3LG4A 4H95A 1RC4A 1DR2A 3FY9X 3NRRA 1ZDRA 1DHIA 4NX6A 1J3KA 4EILA 3F0UX 4X5FA
chains in the Genus database with same CATH superfamily
1DAJA 3DL6A 1IA3A 2ZZAA 1KMVA 3SH2A 3NZCX 5ECCA 1DYJA 3FRAX 1DHJA 3K45A 2KGKA 4XT7A 4DPDA 1RX3A 3F8ZA 2W9SA 1IA2A 1RA3A 4XE6X 3D80A 4X5IA 3K74A 5CC9A 3M08A 1U70A 3CSEA 3QLSA 4KL9A 1HFPA 4KM0A 4HA7A 1DDSA 3KJSA 3ROAA 3NZBX 4ELGA 4QJCA 2D0KA 3FRDX 4IXGX 1RB3A 3QYLA 3SA2A 1J3JA 3QG2A 2GD9A 2P4GA 5U27A 4P68A 5EAJA 3QGTA 1KLKA 4Q0DA 2CD2A 3IA4A 3FQOA 1RH3A 2DHFA 3M09A 1RX5A 3TQ9A 3QFXA 3N0HA 3JWKA 2W3BA 4X5GA 3NU0A 4KBNA 3TQAA 4Q0EA 2ANQA 3SRSX 5ECXA 4EJ1A 2HM9A 3VCOA 3HJ3A 3DRCA 3QLWA 3NZ9X 4PSTA 1DRAA 4GH8A 3TQ8A 4PTJA 1DIUA 3GHCA 4RGCA 2DRCA 4KAKA 2FZHA 3F91A 1DR1A 4QJZD 4PTHA 4OR7A 3NXOA 3S3VA 2W3MA 3IX9A 5JG0X 1S3YA 2LF1A 3TD8A 3EIGA 3FRFX 5JA3A 3NXXA 3KJRA 4XT6A 1PD8A 1JOMA 3I3RA 3FQCA 1MVSA 3D84X 4H96A 1DG7A 2BLBA 1RA9A 3RO9A 3NZDA 3NXYA 4DP3A 3F0QX 1RX8A 3IRMA 3EX8A 4XRBA 3UM8A 3CLBA 4FGHA 4ELEA 4X5HA 3NXVA 1RE7A 4EIZA 1DR7A 4LAGX 3ZPGA 3SRWX 3KY8A 1DG8A 4G8ZX 3SRUX 1DF7A 3FQ0A 4IXED 1MVTA 4KLXA 3E0BA 3QLXA 3F0XX 3QL3A 4HOFA 4H98A 4LAEX 3F8YA 3GYFA 3F0VX 2FZJA 1DLRA 1DREA 3SQYX 1M7AA 2BLCA 2W3VA 2C2SA 3JW3A 2G6VA 3FL8A 4OSGA 3IA5A 1QZFA 3FREX 3TQBA 1IA1A 2JYBA 4CD2A 2W9GA 4I13A 2B3ZA 4H97A 3CL9A 4X5JA 1DG5A 3RG9A 1HFRA 1S3UA 1HFQA 4DPHA 4KY4A 4KY8A 5U26A 3NZ6X 7DFRA 2AZNA 4FGGA 1BOZA 3JVXA 3R33A 3IRNA 4M2XA 1U72A 3JWCA 1OHJA 3K2HA 3JTWA 1CD2A 4QHVA 1CZ3A 4LEKX 5DFRA 4ELHA 1RX6A 1DYRA 1DRFA 1S3VA 1RA1A 1PDBA 3FRBX 4XT4A 3QYOA 4G95A 5HF0X 4G3MA 4M6LA 1E26A 1RF7A 5HT5A 3FYWX 2HQPA 4QLFA 3QLZA 4HOEA 1AO8A 2BLAA 2INQA 3EEMA 4Q6AA 4DDRA 5HSUA 4PSSA 1DDRA 1VDRA 3SAIA 4KJKA 4KYAA 2W9TA 4DFRA 1DRHA 3QLYA 4PDJA 4P66A 2O7PA 4I1NA 1JUVA 3K47A 5CCCA 1DYHA 3FQFA 4ELFA 4KNEA 1PD9A 4KFJA 1DYIA 5HSRA 5HT4A 1DLSA 3F0BX 2CIGA 3ZPCA 1LY4A 4M7VA 5HVEA 2XW7A 3F0SX 4Q67A 1TDRA 3NZAX 3CD2A 3SGYA 4HOGA 3FL9A 1VJ3A 3GHWA 5HF2X 3DL5A 5DXVA 6DFRA 4KJJA 3UM6A 2QK8A 3INVA 3KFYA 1RB2A 1U71A 5FDAA 4KM2A 1IA4A 4KD7A 4P3RA 4LAHX 3EEKA 4QLEA 3JSUA 3SRQX 4NX7A 2L28A 3EELA 3FQVA 4FHBA 3GI2A 4QI9A 3NTZA 4TU5X 1DR6A 3DATA 1DHFA 2C2TA 3EEJA 3DAUA 2ANOA 1DR3A 3HBBA 4XECX 3SRRX 1RA2A 5HUIA 3OCHA 1YHOA 2D5NA 3JWFA 3FYVX 3FS6A 4EIGA 3S7AA 4XT8A 3SA1A 1DISA 4M7UA 3FY8X 1RA8A 1OHKA 1RD7A 1D1GA 3NXTA 2W9HA 1RX2A 2FZIA 2W3AA 1JOLA 1DRBA 1LUDA 3Q1HA 4P3QA 3GHVA 3DG8A 1M78A 5E8QA 2W3WA 3JW5A 3JWMA 1BZFA 1RX9A 5HVBA 1DR5A 3I8AX 4IXFX 4M6KA 3L3RA 3DGAA 1AI9A 2ITHA 2H2QA 3DFRA 5HI6A 4KJLA 1M79A 4PSYA 4HA9A 1RG7A 3QL0A 3UM5A 1LY3A 4KEBA 1RX7A 1SEJA 4ELBA 5HQZA 1KMSA 2OIPA 5HPBA 1RX4A 4M6JA 1S3WA 4QLGA 2HXVA 3QLRA 1AOEA 4ECKA 2OBCA 4XT5A 3SR5X 1RX1A 3KGYA 8DFRA 1J3IA 3FQZA 3NXRA 3S9UA 2BL9A 3OAFA 5HQYA 3IROA 1DR4A 3LG4A 4H95A 1RC4A 1DR2A 3FY9X 3NRRA 1ZDRA 1DHIA 4NX6A 1J3KA 4EILA 3F0UX 4X5FA
chains in the Genus database with same CATH topology
1DAJA 3DL6A 1IA3A 2ZZAA 1KMVA 3SH2A 3NZCX 5ECCA 1DYJA 3FRAX 1DHJA 3K45A 2KGKA 4XT7A 4DPDA 1RX3A 3F8ZA 2W9SA 1IA2A 1RA3A 4XE6X 3D80A 4X5IA 3K74A 5CC9A 3M08A 1U70A 3CSEA 3QLSA 4KL9A 1HFPA 4KM0A 4HA7A 1DDSA 3KJSA 3ROAA 3NZBX 4ELGA 4QJCA 2D0KA 3FRDX 4IXGX 1RB3A 3QYLA 3SA2A 1J3JA 3QG2A 2GD9A 2P4GA 5U27A 4P68A 5EAJA 3QGTA 1KLKA 4Q0DA 2CD2A 3IA4A 3FQOA 1RH3A 2DHFA 3M09A 1RX5A 3TQ9A 3QFXA 3N0HA 3JWKA 2W3BA 4X5GA 3NU0A 4KBNA 3TQAA 4Q0EA 2ANQA 3SRSX 5ECXA 4EJ1A 2HM9A 3VCOA 3HJ3A 3DRCA 3QLWA 3NZ9X 4PSTA 1DRAA 4GH8A 3TQ8A 4PTJA 1DIUA 3GHCA 4RGCA 2DRCA 4KAKA 2FZHA 3F91A 1DR1A 4QJZD 4PTHA 4OR7A 3NXOA 3S3VA 2W3MA 3IX9A 5JG0X 1S3YA 2LF1A 3TD8A 3EIGA 3FRFX 5JA3A 3NXXA 3KJRA 4XT6A 1PD8A 1JOMA 3I3RA 3FQCA 1MVSA 3D84X 4H96A 1DG7A 2BLBA 1RA9A 3RO9A 3NZDA 3NXYA 4DP3A 3F0QX 1RX8A 3IRMA 3EX8A 4XRBA 3UM8A 3CLBA 4FGHA 4ELEA 4X5HA 3NXVA 1RE7A 4EIZA 1DR7A 4LAGX 3ZPGA 3SRWX 3KY8A 1DG8A 4G8ZX 3SRUX 1DF7A 3FQ0A 4IXED 1MVTA 4KLXA 3E0BA 3QLXA 3F0XX 3QL3A 4HOFA 4H98A 4LAEX 3F8YA 3GYFA 3F0VX 2FZJA 1DLRA 1DREA 3SQYX 1M7AA 2BLCA 2W3VA 2C2SA 3JW3A 2G6VA 3FL8A 4OSGA 3IA5A 1QZFA 3FREX 3TQBA 1IA1A 2JYBA 4CD2A 2W9GA 4I13A 2B3ZA 4H97A 3CL9A 4X5JA 1DG5A 3RG9A 1HFRA 1S3UA 1HFQA 4DPHA 4KY4A 4KY8A 5U26A 3NZ6X 7DFRA 2AZNA 4FGGA 1BOZA 3JVXA 3R33A 3IRNA 4M2XA 1U72A 3JWCA 1OHJA 3K2HA 3JTWA 1CD2A 4QHVA 1CZ3A 4LEKX 5DFRA 4ELHA 1RX6A 1DYRA 1DRFA 1S3VA 1RA1A 1PDBA 3FRBX 4XT4A 3QYOA 4G95A 5HF0X 4G3MA 4M6LA 1E26A 1RF7A 5HT5A 3FYWX 2HQPA 4QLFA 3QLZA 4HOEA 1AO8A 2BLAA 2INQA 3EEMA 4Q6AA 4DDRA 5HSUA 4PSSA 1DDRA 1VDRA 3SAIA 4KJKA 4KYAA 2W9TA 4DFRA 1DRHA 3QLYA 4PDJA 4P66A 2O7PA 4I1NA 1JUVA 3K47A 5CCCA 1DYHA 3FQFA 4ELFA 4KNEA 1PD9A 4KFJA 1DYIA 5HSRA 5HT4A 1DLSA 3F0BX 2CIGA 3ZPCA 1LY4A 4M7VA 5HVEA 2XW7A 3F0SX 4Q67A 1TDRA 3NZAX 3CD2A 3SGYA 4HOGA 3FL9A 1VJ3A 3GHWA 5HF2X 3DL5A 5DXVA 6DFRA 4KJJA 3UM6A 2QK8A 3INVA 3KFYA 1RB2A 1U71A 5FDAA 4KM2A 1IA4A 4KD7A 4P3RA 4LAHX 3EEKA 4QLEA 3JSUA 3SRQX 4NX7A 2L28A 3EELA 3FQVA 4FHBA 3GI2A 4QI9A 3NTZA 4TU5X 1DR6A 3DATA 1DHFA 2C2TA 3EEJA 3DAUA 2ANOA 1DR3A 3HBBA 4XECX 3SRRX 1RA2A 5HUIA 3OCHA 1YHOA 2D5NA 3JWFA 3FYVX 3FS6A 4EIGA 3S7AA 4XT8A 3SA1A 1DISA 4M7UA 3FY8X 1RA8A 1OHKA 1RD7A 1D1GA 3NXTA 2W9HA 1RX2A 2FZIA 2W3AA 1JOLA 1DRBA 1LUDA 3Q1HA 4P3QA 3GHVA 3DG8A 1M78A 5E8QA 2W3WA 3JW5A 3JWMA 1BZFA 1RX9A 5HVBA 1DR5A 3I8AX 4IXFX 4M6KA 3L3RA 3DGAA 1AI9A 2ITHA 2H2QA 3DFRA 5HI6A 4KJLA 1M79A 4PSYA 4HA9A 1RG7A 3QL0A 3UM5A 1LY3A 4KEBA 1RX7A 1SEJA 4ELBA 5HQZA 1KMSA 2OIPA 5HPBA 1RX4A 4M6JA 1S3WA 4QLGA 2HXVA 3QLRA 1AOEA 4ECKA 2OBCA 4XT5A 3SR5X 1RX1A 3KGYA 8DFRA 1J3IA 3FQZA 3NXRA 3S9UA 2BL9A 3OAFA 5HQYA 3IROA 1DR4A 3LG4A 4H95A 1RC4A 1DR2A 3FY9X 3NRRA 1ZDRA 1DHIA 4NX6A 1J3KA 4EILA 3F0UX 4X5FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DAJ A;  3DL6 A;  1IA3 A;  2ZZA A;  1KMV A;  3SH2 A;  3NZC X;  5ECC A;  1DYJ A;  3FRA X;  1DHJ A;  3K45 A;  2KGK A;  4XT7 A;  4DPD A;  1RX3 A;  3F8Z A;  2W9S A;  1IA2 A;  1RA3 A;  4XE6 X;  3D80 A;  4X5I A;  3K74 A;  5CC9 A;  3M08 A;  1U70 A;  3CSE A;  3QLS A;  4KL9 A;  1HFP A;  4KM0 A;  4HA7 A;  1DDS A;  3KJS A;  3ROA A;  3NZB X;  4ELG A;  4QJC A;  2D0K A;  3FRD X;  4IXG X;  1RB3 A;  3QYL A;  3SA2 A;  1J3J A;  3QG2 A;  2GD9 A;  2P4G A;  5U27 A;  4P68 A;  5EAJ A;  3QGT A;  1KLK A;  4Q0D A;  2CD2 A;  3IA4 A;  3FQO A;  1RH3 A;  2DHF A;  3M09 A;  1RX5 A;  3TQ9 A;  3QFX A;  3N0H A;  3JWK A;  2W3B A;  4X5G A;  3NU0 A;  4KBN A;  3TQA A;  4Q0E A;  2ANQ A;  3SRS X;  5ECX A;  4EJ1 A;  2HM9 A;  3VCO A;  3HJ3 A;  3DRC A;  3QLW A;  3NZ9 X;  4PST A;  1DRA A;  4GH8 A;  3TQ8 A;  4PTJ A;  1DIU A;  3GHC A;  4RGC A;  2DRC A;  4KAK A;  2FZH A;  3F91 A;  1DR1 A;  4QJZ D;  4PTH A;  4OR7 A;  3NXO A;  3S3V A;  2W3M A;  3IX9 A;  5JG0 X;  1S3Y A;  2LF1 A;  3TD8 A;  3EIG A;  3FRF X;  5JA3 A;  3NXX A;  3KJR A;  4XT6 A;  1PD8 A;  1JOM A;  3I3R A;  3FQC A;  1MVS A;  3D84 X;  4H96 A;  1DG7 A;  2BLB A;  1RA9 A;  3RO9 A;  3NZD A;  3NXY A;  4DP3 A;  3F0Q X;  1RX8 A;  3IRM A;  3EX8 A;  4XRB A;  3UM8 A;  3CLB A;  4FGH A;  4ELE A;  4X5H A;  3NXV A;  1RE7 A;  4EIZ A;  1DR7 A;  4LAG X;  3ZPG A;  3SRW X;  3KY8 A;  1DG8 A;  4G8Z X;  3SRU X;  1DF7 A;  3FQ0 A;  4IXE D;  1MVT A;  4KLX A;  3E0B A;  3QLX A;  3F0X X;  3QL3 A;  4HOF A;  4H98 A;  4LAE X;  3F8Y A;  3GYF A;  3F0V X;  2FZJ A;  1DLR A;  1DRE A;  3SQY X;  1M7A A;  2BLC A;  2W3V A;  2C2S A;  3JW3 A;  2G6V A;  3FL8 A;  4OSG A;  3IA5 A;  1QZF A;  3FRE X;  3TQB A;  1IA1 A;  2JYB A;  4CD2 A;  2W9G A;  4I13 A;  2B3Z A;  4H97 A;  3CL9 A;  4X5J A;  1DG5 A;  3RG9 A;  1HFR A;  1S3U A;  1HFQ A;  4DPH A;  4KY4 A;  4KY8 A;  5U26 A;  3NZ6 X;  7DFR A;  2AZN A;  4FGG A;  1BOZ A;  3JVX A;  3R33 A;  3IRN A;  4M2X A;  1U72 A;  3JWC A;  1OHJ A;  3K2H A;  3JTW A;  1CD2 A;  4QHV A;  1CZ3 A;  4LEK X;  5DFR A;  4ELH A;  1RX6 A;  1DYR A;  1DRF A;  1S3V A;  1RA1 A;  1PDB A;  3FRB X;  4XT4 A;  3QYO A;  4G95 A;  5HF0 X;  4G3M A;  4M6L A;  1E26 A;  1RF7 A;  5HT5 A;  3FYW X;  2HQP A;  4QLF A;  3QLZ A;  4HOE A;  1AO8 A;  2BLA A;  2INQ A;  3EEM A;  4Q6A A;  4DDR A;  5HSU A;  4PSS A;  1DDR A;  1VDR A;  3SAI A;  4KJK A;  4KYA A;  2W9T A;  4DFR A;  1DRH A;  3QLY A;  4PDJ A;  4P66 A;  2O7P A;  4I1N A;  1JUV A;  3K47 A;  5CCC A;  1DYH A;  3FQF A;  4ELF A;  4KNE A;  1PD9 A;  4KFJ A;  1DYI A;  5HSR A;  5HT4 A;  1DLS A;  3F0B X;  2CIG A;  3ZPC A;  1LY4 A;  4M7V A;  5HVE A;  2XW7 A;  3F0S X;  4Q67 A;  1TDR A;  3NZA X;  3CD2 A;  3SGY A;  4HOG A;  3FL9 A;  1VJ3 A;  3GHW A;  5HF2 X;  3DL5 A;  5DXV A;  6DFR A;  4KJJ A;  3UM6 A;  2QK8 A;  3INV A;  3KFY A;  1RB2 A;  1U71 A;  5FDA A;  4KM2 A;  1IA4 A;  4KD7 A;  4P3R A;  4LAH X;  3EEK A;  4QLE A;  3JSU A;  3SRQ X;  4NX7 A;  2L28 A;  3EEL A;  3FQV A;  4FHB A;  3GI2 A;  4QI9 A;  3NTZ A;  4TU5 X;  1DR6 A;  3DAT A;  1DHF A;  2C2T A;  3EEJ A;  3DAU A;  2ANO A;  1DR3 A;  3HBB A;  4XEC X;  3SRR X;  1RA2 A;  5HUI A;  3OCH A;  1YHO A;  2D5N A;  3JWF A;  3FYV X;  3FS6 A;  4EIG A;  3S7A A;  4XT8 A;  3SA1 A;  1DIS A;  4M7U A;  3FY8 X;  1RA8 A;  1OHK A;  1RD7 A;  1D1G A;  3NXT A;  2W9H A;  1RX2 A;  2FZI A;  2W3A A;  1JOL A;  1DRB A;  1LUD A;  3Q1H A;  4P3Q A;  3GHV A;  3DG8 A;  1M78 A;  5E8Q A;  2W3W A;  3JW5 A;  3JWM A;  1BZF A;  1RX9 A;  5HVB A;  1DR5 A;  3I8A X;  4IXF X;  4M6K A;  3L3R A;  3DGA A;  1AI9 A;  2ITH A;  2H2Q A;  3DFR A;  5HI6 A;  4KJL A;  1M79 A;  4PSY A;  4HA9 A;  1RG7 A;  3QL0 A;  3UM5 A;  1LY3 A;  4KEB A;  1RX7 A;  1SEJ A;  4ELB A;  5HQZ A;  1KMS A;  2OIP A;  5HPB A;  1RX4 A;  4M6J A;  1S3W A;  4QLG A;  2HXV A;  3QLR A;  1AOE A;  4ECK A;  2OBC A;  4XT5 A;  3SR5 X;  1RX1 A;  3KGY A;  8DFR A;  1J3I A;  3FQZ A;  3NXR A;  3S9U A;  2BL9 A;  3OAF A;  5HQY A;  3IRO A;  1DR4 A;  3LG4 A;  4H95 A;  1RC4 A;  1DR2 A;  3FY9 X;  3NRR A;  1ZDR A;  1DHI A;  4NX6 A;  1J3K A;  4EIL A;  3F0U X;  4X5F A; 
#chains in the Genus database with same CATH topology
 1DAJ A;  3DL6 A;  1IA3 A;  2ZZA A;  1KMV A;  3SH2 A;  3NZC X;  5ECC A;  1DYJ A;  3FRA X;  1DHJ A;  3K45 A;  2KGK A;  4XT7 A;  4DPD A;  1RX3 A;  3F8Z A;  2W9S A;  1IA2 A;  1RA3 A;  4XE6 X;  3D80 A;  4X5I A;  3K74 A;  5CC9 A;  3M08 A;  1U70 A;  3CSE A;  3QLS A;  4KL9 A;  1HFP A;  4KM0 A;  4HA7 A;  1DDS A;  3KJS A;  3ROA A;  3NZB X;  4ELG A;  4QJC A;  2D0K A;  3FRD X;  4IXG X;  1RB3 A;  3QYL A;  3SA2 A;  1J3J A;  3QG2 A;  2GD9 A;  2P4G A;  5U27 A;  4P68 A;  5EAJ A;  3QGT A;  1KLK A;  4Q0D A;  2CD2 A;  3IA4 A;  3FQO A;  1RH3 A;  2DHF A;  3M09 A;  1RX5 A;  3TQ9 A;  3QFX A;  3N0H A;  3JWK A;  2W3B A;  4X5G A;  3NU0 A;  4KBN A;  3TQA A;  4Q0E A;  2ANQ A;  3SRS X;  5ECX A;  4EJ1 A;  2HM9 A;  3VCO A;  3HJ3 A;  3DRC A;  3QLW A;  3NZ9 X;  4PST A;  1DRA A;  4GH8 A;  3TQ8 A;  4PTJ A;  1DIU A;  3GHC A;  4RGC A;  2DRC A;  4KAK A;  2FZH A;  3F91 A;  1DR1 A;  4QJZ D;  4PTH A;  4OR7 A;  3NXO A;  3S3V A;  2W3M A;  3IX9 A;  5JG0 X;  1S3Y A;  2LF1 A;  3TD8 A;  3EIG A;  3FRF X;  5JA3 A;  3NXX A;  3KJR A;  4XT6 A;  1PD8 A;  1JOM A;  3I3R A;  3FQC A;  1MVS A;  3D84 X;  4H96 A;  1DG7 A;  2BLB A;  1RA9 A;  3RO9 A;  3NZD A;  3NXY A;  4DP3 A;  3F0Q X;  1RX8 A;  3IRM A;  3EX8 A;  4XRB A;  3UM8 A;  3CLB A;  4FGH A;  4ELE A;  4X5H A;  3NXV A;  1RE7 A;  4EIZ A;  1DR7 A;  4LAG X;  3ZPG A;  3SRW X;  3KY8 A;  1DG8 A;  4G8Z X;  3SRU X;  1DF7 A;  3FQ0 A;  4IXE D;  1MVT A;  4KLX A;  3E0B A;  3QLX A;  3F0X X;  3QL3 A;  4HOF A;  4H98 A;  4LAE X;  3F8Y A;  3GYF A;  3F0V X;  2FZJ A;  1DLR A;  1DRE A;  3SQY X;  1M7A A;  2BLC A;  2W3V A;  2C2S A;  3JW3 A;  2G6V A;  3FL8 A;  4OSG A;  3IA5 A;  1QZF A;  3FRE X;  3TQB A;  1IA1 A;  2JYB A;  4CD2 A;  2W9G A;  4I13 A;  2B3Z A;  4H97 A;  3CL9 A;  4X5J A;  1DG5 A;  3RG9 A;  1HFR A;  1S3U A;  1HFQ A;  4DPH A;  4KY4 A;  4KY8 A;  5U26 A;  3NZ6 X;  7DFR A;  2AZN A;  4FGG A;  1BOZ A;  3JVX A;  3R33 A;  3IRN A;  4M2X A;  1U72 A;  3JWC A;  1OHJ A;  3K2H A;  3JTW A;  1CD2 A;  4QHV A;  1CZ3 A;  4LEK X;  5DFR A;  4ELH A;  1RX6 A;  1DYR A;  1DRF A;  1S3V A;  1RA1 A;  1PDB A;  3FRB X;  4XT4 A;  3QYO A;  4G95 A;  5HF0 X;  4G3M A;  4M6L A;  1E26 A;  1RF7 A;  5HT5 A;  3FYW X;  2HQP A;  4QLF A;  3QLZ A;  4HOE A;  1AO8 A;  2BLA A;  2INQ A;  3EEM A;  4Q6A A;  4DDR A;  5HSU A;  4PSS A;  1DDR A;  1VDR A;  3SAI A;  4KJK A;  4KYA A;  2W9T A;  4DFR A;  1DRH A;  3QLY A;  4PDJ A;  4P66 A;  2O7P A;  4I1N A;  1JUV A;  3K47 A;  5CCC A;  1DYH A;  3FQF A;  4ELF A;  4KNE A;  1PD9 A;  4KFJ A;  1DYI A;  5HSR A;  5HT4 A;  1DLS A;  3F0B X;  2CIG A;  3ZPC A;  1LY4 A;  4M7V A;  5HVE A;  2XW7 A;  3F0S X;  4Q67 A;  1TDR A;  3NZA X;  3CD2 A;  3SGY A;  4HOG A;  3FL9 A;  1VJ3 A;  3GHW A;  5HF2 X;  3DL5 A;  5DXV A;  6DFR A;  4KJJ A;  3UM6 A;  2QK8 A;  3INV A;  3KFY A;  1RB2 A;  1U71 A;  5FDA A;  4KM2 A;  1IA4 A;  4KD7 A;  4P3R A;  4LAH X;  3EEK A;  4QLE A;  3JSU A;  3SRQ X;  4NX7 A;  2L28 A;  3EEL A;  3FQV A;  4FHB A;  3GI2 A;  4QI9 A;  3NTZ A;  4TU5 X;  1DR6 A;  3DAT A;  1DHF A;  2C2T A;  3EEJ A;  3DAU A;  2ANO A;  1DR3 A;  3HBB A;  4XEC X;  3SRR X;  1RA2 A;  5HUI A;  3OCH A;  1YHO A;  2D5N A;  3JWF A;  3FYV X;  3FS6 A;  4EIG A;  3S7A A;  4XT8 A;  3SA1 A;  1DIS A;  4M7U A;  3FY8 X;  1RA8 A;  1OHK A;  1RD7 A;  1D1G A;  3NXT A;  2W9H A;  1RX2 A;  2FZI A;  2W3A A;  1JOL A;  1DRB A;  1LUD A;  3Q1H A;  4P3Q A;  3GHV A;  3DG8 A;  1M78 A;  5E8Q A;  2W3W A;  3JW5 A;  3JWM A;  1BZF A;  1RX9 A;  5HVB A;  1DR5 A;  3I8A X;  4IXF X;  4M6K A;  3L3R A;  3DGA A;  1AI9 A;  2ITH A;  2H2Q A;  3DFR A;  5HI6 A;  4KJL A;  1M79 A;  4PSY A;  4HA9 A;  1RG7 A;  3QL0 A;  3UM5 A;  1LY3 A;  4KEB A;  1RX7 A;  1SEJ A;  4ELB A;  5HQZ A;  1KMS A;  2OIP A;  5HPB A;  1RX4 A;  4M6J A;  1S3W A;  4QLG A;  2HXV A;  3QLR A;  1AOE A;  4ECK A;  2OBC A;  4XT5 A;  3SR5 X;  1RX1 A;  3KGY A;  8DFR A;  1J3I A;  3FQZ A;  3NXR A;  3S9U A;  2BL9 A;  3OAF A;  5HQY A;  3IRO A;  1DR4 A;  3LG4 A;  4H95 A;  1RC4 A;  1DR2 A;  3FY9 X;  3NRR A;  1ZDR A;  1DHI A;  4NX6 A;  1J3K A;  4EIL A;  3F0U X;  4X5F A; 
#chains in the Genus database with same CATH homology
 1DAJ A;  3DL6 A;  1IA3 A;  2ZZA A;  1KMV A;  3SH2 A;  3NZC X;  5ECC A;  1DYJ A;  3FRA X;  1DHJ A;  3K45 A;  2KGK A;  4XT7 A;  4DPD A;  1RX3 A;  3F8Z A;  2W9S A;  1IA2 A;  1RA3 A;  4XE6 X;  3D80 A;  4X5I A;  3K74 A;  5CC9 A;  3M08 A;  1U70 A;  3CSE A;  3QLS A;  4KL9 A;  1HFP A;  4KM0 A;  4HA7 A;  1DDS A;  3KJS A;  3ROA A;  3NZB X;  4ELG A;  4QJC A;  2D0K A;  3FRD X;  4IXG X;  1RB3 A;  3QYL A;  3SA2 A;  1J3J A;  3QG2 A;  2GD9 A;  2P4G A;  5U27 A;  4P68 A;  5EAJ A;  3QGT A;  1KLK A;  4Q0D A;  2CD2 A;  3IA4 A;  3FQO A;  1RH3 A;  2DHF A;  3M09 A;  1RX5 A;  3TQ9 A;  3QFX A;  3N0H A;  3JWK A;  2W3B A;  4X5G A;  3NU0 A;  4KBN A;  3TQA A;  4Q0E A;  2ANQ A;  3SRS X;  5ECX A;  4EJ1 A;  2HM9 A;  3VCO A;  3HJ3 A;  3DRC A;  3QLW A;  3NZ9 X;  4PST A;  1DRA A;  4GH8 A;  3TQ8 A;  4PTJ A;  1DIU A;  3GHC A;  4RGC A;  2DRC A;  4KAK A;  2FZH A;  3F91 A;  1DR1 A;  4QJZ D;  4PTH A;  4OR7 A;  3NXO A;  3S3V A;  2W3M A;  3IX9 A;  5JG0 X;  1S3Y A;  2LF1 A;  3TD8 A;  3EIG A;  3FRF X;  5JA3 A;  3NXX A;  3KJR A;  4XT6 A;  1PD8 A;  1JOM A;  3I3R A;  3FQC A;  1MVS A;  3D84 X;  4H96 A;  1DG7 A;  2BLB A;  1RA9 A;  3RO9 A;  3NZD A;  3NXY A;  4DP3 A;  3F0Q X;  1RX8 A;  3IRM A;  3EX8 A;  4XRB A;  3UM8 A;  3CLB A;  4FGH A;  4ELE A;  4X5H A;  3NXV A;  1RE7 A;  4EIZ A;  1DR7 A;  4LAG X;  3ZPG A;  3SRW X;  3KY8 A;  1DG8 A;  4G8Z X;  3SRU X;  1DF7 A;  3FQ0 A;  4IXE D;  1MVT A;  4KLX A;  3E0B A;  3QLX A;  3F0X X;  3QL3 A;  4HOF A;  4H98 A;  4LAE X;  3F8Y A;  3GYF A;  3F0V X;  2FZJ A;  1DLR A;  1DRE A;  3SQY X;  1M7A A;  2BLC A;  2W3V A;  2C2S A;  3JW3 A;  2G6V A;  3FL8 A;  4OSG A;  3IA5 A;  1QZF A;  3FRE X;  3TQB A;  1IA1 A;  2JYB A;  4CD2 A;  2W9G A;  4I13 A;  2B3Z A;  4H97 A;  3CL9 A;  4X5J A;  1DG5 A;  3RG9 A;  1HFR A;  1S3U A;  1HFQ A;  4DPH A;  4KY4 A;  4KY8 A;  5U26 A;  3NZ6 X;  7DFR A;  2AZN A;  4FGG A;  1BOZ A;  3JVX A;  3R33 A;  3IRN A;  4M2X A;  1U72 A;  3JWC A;  1OHJ A;  3K2H A;  3JTW A;  1CD2 A;  4QHV A;  1CZ3 A;  4LEK X;  5DFR A;  4ELH A;  1RX6 A;  1DYR A;  1DRF A;  1S3V A;  1RA1 A;  1PDB A;  3FRB X;  4XT4 A;  3QYO A;  4G95 A;  5HF0 X;  4G3M A;  4M6L A;  1E26 A;  1RF7 A;  5HT5 A;  3FYW X;  2HQP A;  4QLF A;  3QLZ A;  4HOE A;  1AO8 A;  2BLA A;  2INQ A;  3EEM A;  4Q6A A;  4DDR A;  5HSU A;  4PSS A;  1DDR A;  1VDR A;  3SAI A;  4KJK A;  4KYA A;  2W9T A;  4DFR A;  1DRH A;  3QLY A;  4PDJ A;  4P66 A;  2O7P A;  4I1N A;  1JUV A;  3K47 A;  5CCC A;  1DYH A;  3FQF A;  4ELF A;  4KNE A;  1PD9 A;  4KFJ A;  1DYI A;  5HSR A;  5HT4 A;  1DLS A;  3F0B X;  2CIG A;  3ZPC A;  1LY4 A;  4M7V A;  5HVE A;  2XW7 A;  3F0S X;  4Q67 A;  1TDR A;  3NZA X;  3CD2 A;  3SGY A;  4HOG A;  3FL9 A;  1VJ3 A;  3GHW A;  5HF2 X;  3DL5 A;  5DXV A;  6DFR A;  4KJJ A;  3UM6 A;  2QK8 A;  3INV A;  3KFY A;  1RB2 A;  1U71 A;  5FDA A;  4KM2 A;  1IA4 A;  4KD7 A;  4P3R A;  4LAH X;  3EEK A;  4QLE A;  3JSU A;  3SRQ X;  4NX7 A;  2L28 A;  3EEL A;  3FQV A;  4FHB A;  3GI2 A;  4QI9 A;  3NTZ A;  4TU5 X;  1DR6 A;  3DAT A;  1DHF A;  2C2T A;  3EEJ A;  3DAU A;  2ANO A;  1DR3 A;  3HBB A;  4XEC X;  3SRR X;  1RA2 A;  5HUI A;  3OCH A;  1YHO A;  2D5N A;  3JWF A;  3FYV X;  3FS6 A;  4EIG A;  3S7A A;  4XT8 A;  3SA1 A;  1DIS A;  4M7U A;  3FY8 X;  1RA8 A;  1OHK A;  1RD7 A;  1D1G A;  3NXT A;  2W9H A;  1RX2 A;  2FZI A;  2W3A A;  1JOL A;  1DRB A;  1LUD A;  3Q1H A;  4P3Q A;  3GHV A;  3DG8 A;  1M78 A;  5E8Q A;  2W3W A;  3JW5 A;  3JWM A;  1BZF A;  1RX9 A;  5HVB A;  1DR5 A;  3I8A X;  4IXF X;  4M6K A;  3L3R A;  3DGA A;  1AI9 A;  2ITH A;  2H2Q A;  3DFR A;  5HI6 A;  4KJL A;  1M79 A;  4PSY A;  4HA9 A;  1RG7 A;  3QL0 A;  3UM5 A;  1LY3 A;  4KEB A;  1RX7 A;  1SEJ A;  4ELB A;  5HQZ A;  1KMS A;  2OIP A;  5HPB A;  1RX4 A;  4M6J A;  1S3W A;  4QLG A;  2HXV A;  3QLR A;  1AOE A;  4ECK A;  2OBC A;  4XT5 A;  3SR5 X;  1RX1 A;  3KGY A;  8DFR A;  1J3I A;  3FQZ A;  3NXR A;  3S9U A;  2BL9 A;  3OAF A;  5HQY A;  3IRO A;  1DR4 A;  3LG4 A;  4H95 A;  1RC4 A;  1DR2 A;  3FY9 X;  3NRR A;  1ZDR A;  1DHI A;  4NX6 A;  1J3K A;  4EIL A;  3F0U X;  4X5F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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