4KBNA

Human dihydrofolate reductase complexed with nadph and 5-{3-[3-(3,5-pyrimidine)]-phenyl-prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4diamine
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 53
structure length 186
sequence length 186
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-04-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4kbnA00
3R33A 1KLKA 3K2HA 1RH3A 2HM9A 1DYIA 4P68A 3INVA 2QK8A 4QHVA 5HSUA 1RB3A 2W9GA 4P3RA 3FY8X 3FQ0A 1DYRA 4LAEX 4KBNA 4X5JA 2G6VA 1RD7A 3RO9A 1DREA 1DG5A 2O7PA 2W3BA 4PSSA 1DLSA 4X5IA 3NXYA 4OR7A 3F0UX 4KEBA 4KJJA 1DISA 1DYJA 2FZJA 4KAKA 3DG8A 1DR3A 5HQYA 3SA1A 4PSYA 2JYBA 1HFQA 4X5GA 7DFRA 3D80A 3F0QX 3JWFA 3NXOA 4ECKA 5FDAA 4NX7A 1LUDA 3NU0A 1DRFA 1IA1A 3SGYA 4ELGA 5JG0X 3VCOA 3JTWA 2D0KA 5HQZA 5U27A 3QL3A 2W9SA 3JW5A 3TQBA 4EJ1A 2OIPA 3OCHA 1DG7A 1DR7A 2BLAA 3QLYA 3EELA 3GHVA 3DL5A 3F91A 3EX8A 3JWMA 4XE6X 3TQ8A 1HFRA 3DGAA 2H2QA 1DRAA 3SRUX 4DP3A 3QGTA 3NXRA 4PTHA 4NX6A 2INQA 3HBBA 2DRCA 4GH8A 2CD2A 5EAJA 3NXXA 3DATA 5DXVA 3QLRA 3KY8A 3NZDA 3DFRA 4H97A 5E8QA 1DR2A 2FZIA 1BZFA 1IA3A 3JWKA 1J3IA 5DFRA 4PSTA 2W3WA 2P4GA 1OHKA 1RX5A 3QLSA 3QLWA 4QLFA 3QYOA 3DRCA 3SRWX 4KJKA 3UM5A 3E0BA 4DFRA 1RX3A 2HXVA 1RA8A 3SR5X 1RX8A 8DFRA 5CC9A 4QLGA 1J3JA 4KD7A 4HA7A 3TQ9A 4LEKX 3LG4A 1DG8A 3QFXA 3FYVX 4ELBA 4KY8A 3DAUA 1QZFA 2W9HA 3FYWX 4KJLA 2D5NA 1RF7A 1VJ3A 3SRQX 1ZDRA 2BL9A 3IRNA 4DDRA 4HA9A 3SH2A 3M08A 3FQFA 3QLZA 2OBCA 3NZCX 1U71A 1E26A 3IRMA 3I3RA 2C2SA 3UM8A 4QJCA 1DF7A 2BLBA 3JVXA 4XECX 4Q67A 2W9TA 4TU5X 3NZ9X 2ANQA 1RX9A 4M6KA 3SQYX 1RG7A 1CD2A 1RA1A 1PDBA 4QLEA 2ANOA 1JUVA 1RX6A 5HUIA 3NRRA 1S3VA 3K47A 1RX2A 3FY9X 3UM6A 4G8ZX 2W3MA 3FL9A 1DIUA 5HSRA 3CL9A 2FZHA 3F0BX 4M6JA 4LAHX 1M7AA 5HVBA 3F0XX 3SAIA 4H96A 4QI9A 3FRBX 4IXGX 4EIGA 4HOFA 4KL9A 3KJSA 4G3MA 4H95A 3FRDX 3SRSX 1DHIA 4KM2A 1IA2A 3JWCA 1DR6A 1DRHA 1TDRA 1S3UA 5HVEA 1DHFA 1DYHA 4RGCA 3NXVA 1SEJA 4ELHA 3RG9A 3NZ6X 1RX7A 3GYFA 3KJRA 4KNEA 5ECXA 1VDRA 2CIGA 3NTZA 4FGGA 5HF0X 4CD2A 1HFPA 4IXFX 5CCCA 3CSEA 1PD9A 3JSUA 3FQCA 1RA9A 3NZAX 1DR4A 2BLCA 3N0HA 3F8YA 3F0SX 4OSGA 2W3AA 4P3QA 5HT4A 5HI6A 1RB2A 1AOEA 3NXTA 3M09A 1RC4A 3I8AX 1RX1A 4Q0EA 4ELEA 2L28A 2KGKA 1JOLA 1RE7A 4X5FA 4IXED 3S9UA 3FREX 1U70A 4XT4A 5U26A 3F8ZA 3CLBA 3L3RA 1MVSA 3EIGA 4PDJA 4KLXA 4M7VA 3K45A 2LF1A 4KYAA 3FL8A 3QG2A 3K74A 2B3ZA 1YHOA 2ITHA 1BOZA 3IX9A 1AI9A 4FGHA 4XT7A 2W3VA 1J3KA 1KMSA 4Q0DA 4KY4A 3IA4A 4H98A 3GI2A 3Q1HA 1PD8A 1DAJA 3QYLA 3QLXA 4HOEA 3ZPCA 4XT6A 1DR5A 3FRAX 1AO8A 2C2TA 4KFJA 3KGYA 1S3YA 4DPHA 4X5HA 1DDSA 1S3WA 1U72A 1DDRA 1DHJA 1DR1A 6DFRA 2XW7A 1DRBA 2AZNA 3GHCA 3SRRX 1JOMA 1MVTA 3ZPGA 2HQPA 1LY4A 3TD8A 3S3VA 4QJZD 3IROA 3FQOA 5HPBA 1OHJA 4HOGA 4P66A 3CD2A 3FS6A 5HT5A 3JW3A 3HJ3A 3FQVA 2GD9A 3OAFA 4KM0A 3S7AA 1M78A 3QL0A 5ECCA 4EIZA 1M79A 4M6LA 4M2XA 4DPDA 3DL6A 5JA3A 4FHBA 4G95A 5HF2X 4Q6AA 3FQZA 3NZBX 3ROAA 3SA2A 3FRFX 4ELFA 4XT8A 1DLRA 4XRBA 1IA4A 4I1NA 1KMVA 1LY3A 3TQAA 4I13A 3GHWA 1D1GA 1RA2A 3EEMA 4LAGX 3KFYA 2ZZAA 3F0VX 2DHFA 4PTJA 3D84X 1RX4A 3EEKA 1RA3A 1CZ3A 3IA5A 4EILA 4M7UA 4XT5A 3EEJA
chains in the Genus database with same CATH superfamily
3R33A 1KLKA 3K2HA 1RH3A 2HM9A 1DYIA 4P68A 3INVA 2QK8A 4QHVA 5HSUA 1RB3A 2W9GA 4P3RA 3FY8X 3FQ0A 1DYRA 4LAEX 4KBNA 4X5JA 2G6VA 1RD7A 3RO9A 1DREA 1DG5A 2O7PA 2W3BA 4PSSA 1DLSA 4X5IA 3NXYA 4OR7A 3F0UX 4KEBA 4KJJA 1DISA 1DYJA 2FZJA 4KAKA 3DG8A 1DR3A 5HQYA 3SA1A 4PSYA 2JYBA 1HFQA 4X5GA 7DFRA 3D80A 3F0QX 3JWFA 3NXOA 4ECKA 5FDAA 4NX7A 1LUDA 3NU0A 1DRFA 1IA1A 3SGYA 4ELGA 5JG0X 3VCOA 3JTWA 2D0KA 5HQZA 5U27A 3QL3A 2W9SA 3JW5A 3TQBA 4EJ1A 2OIPA 3OCHA 1DG7A 1DR7A 2BLAA 3QLYA 3EELA 3GHVA 3DL5A 3F91A 3EX8A 3JWMA 4XE6X 3TQ8A 1HFRA 3DGAA 2H2QA 1DRAA 3SRUX 4DP3A 3QGTA 3NXRA 4PTHA 4NX6A 2INQA 3HBBA 2DRCA 4GH8A 2CD2A 5EAJA 3NXXA 3DATA 5DXVA 3QLRA 3KY8A 3NZDA 3DFRA 4H97A 5E8QA 1DR2A 2FZIA 1BZFA 1IA3A 3JWKA 1J3IA 5DFRA 4PSTA 2W3WA 2P4GA 1OHKA 1RX5A 3QLSA 3QLWA 4QLFA 3QYOA 3DRCA 3SRWX 4KJKA 3UM5A 3E0BA 4DFRA 1RX3A 2HXVA 1RA8A 3SR5X 1RX8A 8DFRA 5CC9A 4QLGA 1J3JA 4KD7A 4HA7A 3TQ9A 4LEKX 3LG4A 1DG8A 3QFXA 3FYVX 4ELBA 4KY8A 3DAUA 1QZFA 2W9HA 3FYWX 4KJLA 2D5NA 1RF7A 1VJ3A 3SRQX 1ZDRA 2BL9A 3IRNA 4DDRA 4HA9A 3SH2A 3M08A 3FQFA 3QLZA 2OBCA 3NZCX 1U71A 1E26A 3IRMA 3I3RA 2C2SA 3UM8A 4QJCA 1DF7A 2BLBA 3JVXA 4XECX 4Q67A 2W9TA 4TU5X 3NZ9X 2ANQA 1RX9A 4M6KA 3SQYX 1RG7A 1CD2A 1RA1A 1PDBA 4QLEA 2ANOA 1JUVA 1RX6A 5HUIA 3NRRA 1S3VA 3K47A 1RX2A 3FY9X 3UM6A 4G8ZX 2W3MA 3FL9A 1DIUA 5HSRA 3CL9A 2FZHA 3F0BX 4M6JA 4LAHX 1M7AA 5HVBA 3F0XX 3SAIA 4H96A 4QI9A 3FRBX 4IXGX 4EIGA 4HOFA 4KL9A 3KJSA 4G3MA 4H95A 3FRDX 3SRSX 1DHIA 4KM2A 1IA2A 3JWCA 1DR6A 1DRHA 1TDRA 1S3UA 5HVEA 1DHFA 1DYHA 4RGCA 3NXVA 1SEJA 4ELHA 3RG9A 3NZ6X 1RX7A 3GYFA 3KJRA 4KNEA 5ECXA 1VDRA 2CIGA 3NTZA 4FGGA 5HF0X 4CD2A 1HFPA 4IXFX 5CCCA 3CSEA 1PD9A 3JSUA 3FQCA 1RA9A 3NZAX 1DR4A 2BLCA 3N0HA 3F8YA 3F0SX 4OSGA 2W3AA 4P3QA 5HT4A 5HI6A 1RB2A 1AOEA 3NXTA 3M09A 1RC4A 3I8AX 1RX1A 4Q0EA 4ELEA 2L28A 2KGKA 1JOLA 1RE7A 4X5FA 4IXED 3S9UA 3FREX 1U70A 4XT4A 5U26A 3F8ZA 3CLBA 3L3RA 1MVSA 3EIGA 4PDJA 4KLXA 4M7VA 3K45A 2LF1A 4KYAA 3FL8A 3QG2A 3K74A 2B3ZA 1YHOA 2ITHA 1BOZA 3IX9A 1AI9A 4FGHA 4XT7A 2W3VA 1J3KA 1KMSA 4Q0DA 4KY4A 3IA4A 4H98A 3GI2A 3Q1HA 1PD8A 1DAJA 3QYLA 3QLXA 4HOEA 3ZPCA 4XT6A 1DR5A 3FRAX 1AO8A 2C2TA 4KFJA 3KGYA 1S3YA 4DPHA 4X5HA 1DDSA 1S3WA 1U72A 1DDRA 1DHJA 1DR1A 6DFRA 2XW7A 1DRBA 2AZNA 3GHCA 3SRRX 1JOMA 1MVTA 3ZPGA 2HQPA 1LY4A 3TD8A 3S3VA 4QJZD 3IROA 3FQOA 5HPBA 1OHJA 4HOGA 4P66A 3CD2A 3FS6A 5HT5A 3JW3A 3HJ3A 3FQVA 2GD9A 3OAFA 4KM0A 3S7AA 1M78A 3QL0A 5ECCA 4EIZA 1M79A 4M6LA 4M2XA 4DPDA 3DL6A 5JA3A 4FHBA 4G95A 5HF2X 4Q6AA 3FQZA 3NZBX 3ROAA 3SA2A 3FRFX 4ELFA 4XT8A 1DLRA 4XRBA 1IA4A 4I1NA 1KMVA 1LY3A 3TQAA 4I13A 3GHWA 1D1GA 1RA2A 3EEMA 4LAGX 3KFYA 2ZZAA 3F0VX 2DHFA 4PTJA 3D84X 1RX4A 3EEKA 1RA3A 1CZ3A 3IA5A 4EILA 4M7UA 4XT5A 3EEJA
chains in the Genus database with same CATH topology
3R33A 1KLKA 3K2HA 1RH3A 2HM9A 1DYIA 4P68A 3INVA 2QK8A 4QHVA 5HSUA 1RB3A 2W9GA 4P3RA 3FY8X 3FQ0A 1DYRA 4LAEX 4KBNA 4X5JA 2G6VA 1RD7A 3RO9A 1DREA 1DG5A 2O7PA 2W3BA 4PSSA 1DLSA 4X5IA 3NXYA 4OR7A 3F0UX 4KEBA 4KJJA 1DISA 1DYJA 2FZJA 4KAKA 3DG8A 1DR3A 5HQYA 3SA1A 4PSYA 2JYBA 1HFQA 4X5GA 7DFRA 3D80A 3F0QX 3JWFA 3NXOA 4ECKA 5FDAA 4NX7A 1LUDA 3NU0A 1DRFA 1IA1A 3SGYA 4ELGA 5JG0X 3VCOA 3JTWA 2D0KA 5HQZA 5U27A 3QL3A 2W9SA 3JW5A 3TQBA 4EJ1A 2OIPA 3OCHA 1DG7A 1DR7A 2BLAA 3QLYA 3EELA 3GHVA 3DL5A 3F91A 3EX8A 3JWMA 4XE6X 3TQ8A 1HFRA 3DGAA 2H2QA 1DRAA 3SRUX 4DP3A 3QGTA 3NXRA 4PTHA 4NX6A 2INQA 3HBBA 2DRCA 4GH8A 2CD2A 5EAJA 3NXXA 3DATA 5DXVA 3QLRA 3KY8A 3NZDA 3DFRA 4H97A 5E8QA 1DR2A 2FZIA 1BZFA 1IA3A 3JWKA 1J3IA 5DFRA 4PSTA 2W3WA 2P4GA 1OHKA 1RX5A 3QLSA 3QLWA 4QLFA 3QYOA 3DRCA 3SRWX 4KJKA 3UM5A 3E0BA 4DFRA 1RX3A 2HXVA 1RA8A 3SR5X 1RX8A 8DFRA 5CC9A 4QLGA 1J3JA 4KD7A 4HA7A 3TQ9A 4LEKX 3LG4A 1DG8A 3QFXA 3FYVX 4ELBA 4KY8A 3DAUA 1QZFA 2W9HA 3FYWX 4KJLA 2D5NA 1RF7A 1VJ3A 3SRQX 1ZDRA 2BL9A 3IRNA 4DDRA 4HA9A 3SH2A 3M08A 3FQFA 3QLZA 2OBCA 3NZCX 1U71A 1E26A 3IRMA 3I3RA 2C2SA 3UM8A 4QJCA 1DF7A 2BLBA 3JVXA 4XECX 4Q67A 2W9TA 4TU5X 3NZ9X 2ANQA 1RX9A 4M6KA 3SQYX 1RG7A 1CD2A 1RA1A 1PDBA 4QLEA 2ANOA 1JUVA 1RX6A 5HUIA 3NRRA 1S3VA 3K47A 1RX2A 3FY9X 3UM6A 4G8ZX 2W3MA 3FL9A 1DIUA 5HSRA 3CL9A 2FZHA 3F0BX 4M6JA 4LAHX 1M7AA 5HVBA 3F0XX 3SAIA 4H96A 4QI9A 3FRBX 4IXGX 4EIGA 4HOFA 4KL9A 3KJSA 4G3MA 4H95A 3FRDX 3SRSX 1DHIA 4KM2A 1IA2A 3JWCA 1DR6A 1DRHA 1TDRA 1S3UA 5HVEA 1DHFA 1DYHA 4RGCA 3NXVA 1SEJA 4ELHA 3RG9A 3NZ6X 1RX7A 3GYFA 3KJRA 4KNEA 5ECXA 1VDRA 2CIGA 3NTZA 4FGGA 5HF0X 4CD2A 1HFPA 4IXFX 5CCCA 3CSEA 1PD9A 3JSUA 3FQCA 1RA9A 3NZAX 1DR4A 2BLCA 3N0HA 3F8YA 3F0SX 4OSGA 2W3AA 4P3QA 5HT4A 5HI6A 1RB2A 1AOEA 3NXTA 3M09A 1RC4A 3I8AX 1RX1A 4Q0EA 4ELEA 2L28A 2KGKA 1JOLA 1RE7A 4X5FA 4IXED 3S9UA 3FREX 1U70A 4XT4A 5U26A 3F8ZA 3CLBA 3L3RA 1MVSA 3EIGA 4PDJA 4KLXA 4M7VA 3K45A 2LF1A 4KYAA 3FL8A 3QG2A 3K74A 2B3ZA 1YHOA 2ITHA 1BOZA 3IX9A 1AI9A 4FGHA 4XT7A 2W3VA 1J3KA 1KMSA 4Q0DA 4KY4A 3IA4A 4H98A 3GI2A 3Q1HA 1PD8A 1DAJA 3QYLA 3QLXA 4HOEA 3ZPCA 4XT6A 1DR5A 3FRAX 1AO8A 2C2TA 4KFJA 3KGYA 1S3YA 4DPHA 4X5HA 1DDSA 1S3WA 1U72A 1DDRA 1DHJA 1DR1A 6DFRA 2XW7A 1DRBA 2AZNA 3GHCA 3SRRX 1JOMA 1MVTA 3ZPGA 2HQPA 1LY4A 3TD8A 3S3VA 4QJZD 3IROA 3FQOA 5HPBA 1OHJA 4HOGA 4P66A 3CD2A 3FS6A 5HT5A 3JW3A 3HJ3A 3FQVA 2GD9A 3OAFA 4KM0A 3S7AA 1M78A 3QL0A 5ECCA 4EIZA 1M79A 4M6LA 4M2XA 4DPDA 3DL6A 5JA3A 4FHBA 4G95A 5HF2X 4Q6AA 3FQZA 3NZBX 3ROAA 3SA2A 3FRFX 4ELFA 4XT8A 1DLRA 4XRBA 1IA4A 4I1NA 1KMVA 1LY3A 3TQAA 4I13A 3GHWA 1D1GA 1RA2A 3EEMA 4LAGX 3KFYA 2ZZAA 3F0VX 2DHFA 4PTJA 3D84X 1RX4A 3EEKA 1RA3A 1CZ3A 3IA5A 4EILA 4M7UA 4XT5A 3EEJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3R33 A;  1KLK A;  3K2H A;  1RH3 A;  2HM9 A;  1DYI A;  4P68 A;  3INV A;  2QK8 A;  4QHV A;  5HSU A;  1RB3 A;  2W9G A;  4P3R A;  3FY8 X;  3FQ0 A;  1DYR A;  4LAE X;  4KBN A;  4X5J A;  2G6V A;  1RD7 A;  3RO9 A;  1DRE A;  1DG5 A;  2O7P A;  2W3B A;  4PSS A;  1DLS A;  4X5I A;  3NXY A;  4OR7 A;  3F0U X;  4KEB A;  4KJJ A;  1DIS A;  1DYJ A;  2FZJ A;  4KAK A;  3DG8 A;  1DR3 A;  5HQY A;  3SA1 A;  4PSY A;  2JYB A;  1HFQ A;  4X5G A;  7DFR A;  3D80 A;  3F0Q X;  3JWF A;  3NXO A;  4ECK A;  5FDA A;  4NX7 A;  1LUD A;  3NU0 A;  1DRF A;  1IA1 A;  3SGY A;  4ELG A;  5JG0 X;  3VCO A;  3JTW A;  2D0K A;  5HQZ A;  5U27 A;  3QL3 A;  2W9S A;  3JW5 A;  3TQB A;  4EJ1 A;  2OIP A;  3OCH A;  1DG7 A;  1DR7 A;  2BLA A;  3QLY A;  3EEL A;  3GHV A;  3DL5 A;  3F91 A;  3EX8 A;  3JWM A;  4XE6 X;  3TQ8 A;  1HFR A;  3DGA A;  2H2Q A;  1DRA A;  3SRU X;  4DP3 A;  3QGT A;  3NXR A;  4PTH A;  4NX6 A;  2INQ A;  3HBB A;  2DRC A;  4GH8 A;  2CD2 A;  5EAJ A;  3NXX A;  3DAT A;  5DXV A;  3QLR A;  3KY8 A;  3NZD A;  3DFR A;  4H97 A;  5E8Q A;  1DR2 A;  2FZI A;  1BZF A;  1IA3 A;  3JWK A;  1J3I A;  5DFR A;  4PST A;  2W3W A;  2P4G A;  1OHK A;  1RX5 A;  3QLS A;  3QLW A;  4QLF A;  3QYO A;  3DRC A;  3SRW X;  4KJK A;  3UM5 A;  3E0B A;  4DFR A;  1RX3 A;  2HXV A;  1RA8 A;  3SR5 X;  1RX8 A;  8DFR A;  5CC9 A;  4QLG A;  1J3J A;  4KD7 A;  4HA7 A;  3TQ9 A;  4LEK X;  3LG4 A;  1DG8 A;  3QFX A;  3FYV X;  4ELB A;  4KY8 A;  3DAU A;  1QZF A;  2W9H A;  3FYW X;  4KJL A;  2D5N A;  1RF7 A;  1VJ3 A;  3SRQ X;  1ZDR A;  2BL9 A;  3IRN A;  4DDR A;  4HA9 A;  3SH2 A;  3M08 A;  3FQF A;  3QLZ A;  2OBC A;  3NZC X;  1U71 A;  1E26 A;  3IRM A;  3I3R A;  2C2S A;  3UM8 A;  4QJC A;  1DF7 A;  2BLB A;  3JVX A;  4XEC X;  4Q67 A;  2W9T A;  4TU5 X;  3NZ9 X;  2ANQ A;  1RX9 A;  4M6K A;  3SQY X;  1RG7 A;  1CD2 A;  1RA1 A;  1PDB A;  4QLE A;  2ANO A;  1JUV A;  1RX6 A;  5HUI A;  3NRR A;  1S3V A;  3K47 A;  1RX2 A;  3FY9 X;  3UM6 A;  4G8Z X;  2W3M A;  3FL9 A;  1DIU A;  5HSR A;  3CL9 A;  2FZH A;  3F0B X;  4M6J A;  4LAH X;  1M7A A;  5HVB A;  3F0X X;  3SAI A;  4H96 A;  4QI9 A;  3FRB X;  4IXG X;  4EIG A;  4HOF A;  4KL9 A;  3KJS A;  4G3M A;  4H95 A;  3FRD X;  3SRS X;  1DHI A;  4KM2 A;  1IA2 A;  3JWC A;  1DR6 A;  1DRH A;  1TDR A;  1S3U A;  5HVE A;  1DHF A;  1DYH A;  4RGC A;  3NXV A;  1SEJ A;  4ELH A;  3RG9 A;  3NZ6 X;  1RX7 A;  3GYF A;  3KJR A;  4KNE A;  5ECX A;  1VDR A;  2CIG A;  3NTZ A;  4FGG A;  5HF0 X;  4CD2 A;  1HFP A;  4IXF X;  5CCC A;  3CSE A;  1PD9 A;  3JSU A;  3FQC A;  1RA9 A;  3NZA X;  1DR4 A;  2BLC A;  3N0H A;  3F8Y A;  3F0S X;  4OSG A;  2W3A A;  4P3Q A;  5HT4 A;  5HI6 A;  1RB2 A;  1AOE A;  3NXT A;  3M09 A;  1RC4 A;  3I8A X;  1RX1 A;  4Q0E A;  4ELE A;  2L28 A;  2KGK A;  1JOL A;  1RE7 A;  4X5F A;  4IXE D;  3S9U A;  3FRE X;  1U70 A;  4XT4 A;  5U26 A;  3F8Z A;  3CLB A;  3L3R A;  1MVS A;  3EIG A;  4PDJ A;  4KLX A;  4M7V A;  3K45 A;  2LF1 A;  4KYA A;  3FL8 A;  3QG2 A;  3K74 A;  2B3Z A;  1YHO A;  2ITH A;  1BOZ A;  3IX9 A;  1AI9 A;  4FGH A;  4XT7 A;  2W3V A;  1J3K A;  1KMS A;  4Q0D A;  4KY4 A;  3IA4 A;  4H98 A;  3GI2 A;  3Q1H A;  1PD8 A;  1DAJ A;  3QYL A;  3QLX A;  4HOE A;  3ZPC A;  4XT6 A;  1DR5 A;  3FRA X;  1AO8 A;  2C2T A;  4KFJ A;  3KGY A;  1S3Y A;  4DPH A;  4X5H A;  1DDS A;  1S3W A;  1U72 A;  1DDR A;  1DHJ A;  1DR1 A;  6DFR A;  2XW7 A;  1DRB A;  2AZN A;  3GHC A;  3SRR X;  1JOM A;  1MVT A;  3ZPG A;  2HQP A;  1LY4 A;  3TD8 A;  3S3V A;  4QJZ D;  3IRO A;  3FQO A;  5HPB A;  1OHJ A;  4HOG A;  4P66 A;  3CD2 A;  3FS6 A;  5HT5 A;  3JW3 A;  3HJ3 A;  3FQV A;  2GD9 A;  3OAF A;  4KM0 A;  3S7A A;  1M78 A;  3QL0 A;  5ECC A;  4EIZ A;  1M79 A;  4M6L A;  4M2X A;  4DPD A;  3DL6 A;  5JA3 A;  4FHB A;  4G95 A;  5HF2 X;  4Q6A A;  3FQZ A;  3NZB X;  3ROA A;  3SA2 A;  3FRF X;  4ELF A;  4XT8 A;  1DLR A;  4XRB A;  1IA4 A;  4I1N A;  1KMV A;  1LY3 A;  3TQA A;  4I13 A;  3GHW A;  1D1G A;  1RA2 A;  3EEM A;  4LAG X;  3KFY A;  2ZZA A;  3F0V X;  2DHF A;  4PTJ A;  3D84 X;  1RX4 A;  3EEK A;  1RA3 A;  1CZ3 A;  3IA5 A;  4EIL A;  4M7U A;  4XT5 A;  3EEJ A; 
#chains in the Genus database with same CATH topology
 3R33 A;  1KLK A;  3K2H A;  1RH3 A;  2HM9 A;  1DYI A;  4P68 A;  3INV A;  2QK8 A;  4QHV A;  5HSU A;  1RB3 A;  2W9G A;  4P3R A;  3FY8 X;  3FQ0 A;  1DYR A;  4LAE X;  4KBN A;  4X5J A;  2G6V A;  1RD7 A;  3RO9 A;  1DRE A;  1DG5 A;  2O7P A;  2W3B A;  4PSS A;  1DLS A;  4X5I A;  3NXY A;  4OR7 A;  3F0U X;  4KEB A;  4KJJ A;  1DIS A;  1DYJ A;  2FZJ A;  4KAK A;  3DG8 A;  1DR3 A;  5HQY A;  3SA1 A;  4PSY A;  2JYB A;  1HFQ A;  4X5G A;  7DFR A;  3D80 A;  3F0Q X;  3JWF A;  3NXO A;  4ECK A;  5FDA A;  4NX7 A;  1LUD A;  3NU0 A;  1DRF A;  1IA1 A;  3SGY A;  4ELG A;  5JG0 X;  3VCO A;  3JTW A;  2D0K A;  5HQZ A;  5U27 A;  3QL3 A;  2W9S A;  3JW5 A;  3TQB A;  4EJ1 A;  2OIP A;  3OCH A;  1DG7 A;  1DR7 A;  2BLA A;  3QLY A;  3EEL A;  3GHV A;  3DL5 A;  3F91 A;  3EX8 A;  3JWM A;  4XE6 X;  3TQ8 A;  1HFR A;  3DGA A;  2H2Q A;  1DRA A;  3SRU X;  4DP3 A;  3QGT A;  3NXR A;  4PTH A;  4NX6 A;  2INQ A;  3HBB A;  2DRC A;  4GH8 A;  2CD2 A;  5EAJ A;  3NXX A;  3DAT A;  5DXV A;  3QLR A;  3KY8 A;  3NZD A;  3DFR A;  4H97 A;  5E8Q A;  1DR2 A;  2FZI A;  1BZF A;  1IA3 A;  3JWK A;  1J3I A;  5DFR A;  4PST A;  2W3W A;  2P4G A;  1OHK A;  1RX5 A;  3QLS A;  3QLW A;  4QLF A;  3QYO A;  3DRC A;  3SRW X;  4KJK A;  3UM5 A;  3E0B A;  4DFR A;  1RX3 A;  2HXV A;  1RA8 A;  3SR5 X;  1RX8 A;  8DFR A;  5CC9 A;  4QLG A;  1J3J A;  4KD7 A;  4HA7 A;  3TQ9 A;  4LEK X;  3LG4 A;  1DG8 A;  3QFX A;  3FYV X;  4ELB A;  4KY8 A;  3DAU A;  1QZF A;  2W9H A;  3FYW X;  4KJL A;  2D5N A;  1RF7 A;  1VJ3 A;  3SRQ X;  1ZDR A;  2BL9 A;  3IRN A;  4DDR A;  4HA9 A;  3SH2 A;  3M08 A;  3FQF A;  3QLZ A;  2OBC A;  3NZC X;  1U71 A;  1E26 A;  3IRM A;  3I3R A;  2C2S A;  3UM8 A;  4QJC A;  1DF7 A;  2BLB A;  3JVX A;  4XEC X;  4Q67 A;  2W9T A;  4TU5 X;  3NZ9 X;  2ANQ A;  1RX9 A;  4M6K A;  3SQY X;  1RG7 A;  1CD2 A;  1RA1 A;  1PDB A;  4QLE A;  2ANO A;  1JUV A;  1RX6 A;  5HUI A;  3NRR A;  1S3V A;  3K47 A;  1RX2 A;  3FY9 X;  3UM6 A;  4G8Z X;  2W3M A;  3FL9 A;  1DIU A;  5HSR A;  3CL9 A;  2FZH A;  3F0B X;  4M6J A;  4LAH X;  1M7A A;  5HVB A;  3F0X X;  3SAI A;  4H96 A;  4QI9 A;  3FRB X;  4IXG X;  4EIG A;  4HOF A;  4KL9 A;  3KJS A;  4G3M A;  4H95 A;  3FRD X;  3SRS X;  1DHI A;  4KM2 A;  1IA2 A;  3JWC A;  1DR6 A;  1DRH A;  1TDR A;  1S3U A;  5HVE A;  1DHF A;  1DYH A;  4RGC A;  3NXV A;  1SEJ A;  4ELH A;  3RG9 A;  3NZ6 X;  1RX7 A;  3GYF A;  3KJR A;  4KNE A;  5ECX A;  1VDR A;  2CIG A;  3NTZ A;  4FGG A;  5HF0 X;  4CD2 A;  1HFP A;  4IXF X;  5CCC A;  3CSE A;  1PD9 A;  3JSU A;  3FQC A;  1RA9 A;  3NZA X;  1DR4 A;  2BLC A;  3N0H A;  3F8Y A;  3F0S X;  4OSG A;  2W3A A;  4P3Q A;  5HT4 A;  5HI6 A;  1RB2 A;  1AOE A;  3NXT A;  3M09 A;  1RC4 A;  3I8A X;  1RX1 A;  4Q0E A;  4ELE A;  2L28 A;  2KGK A;  1JOL A;  1RE7 A;  4X5F A;  4IXE D;  3S9U A;  3FRE X;  1U70 A;  4XT4 A;  5U26 A;  3F8Z A;  3CLB A;  3L3R A;  1MVS A;  3EIG A;  4PDJ A;  4KLX A;  4M7V A;  3K45 A;  2LF1 A;  4KYA A;  3FL8 A;  3QG2 A;  3K74 A;  2B3Z A;  1YHO A;  2ITH A;  1BOZ A;  3IX9 A;  1AI9 A;  4FGH A;  4XT7 A;  2W3V A;  1J3K A;  1KMS A;  4Q0D A;  4KY4 A;  3IA4 A;  4H98 A;  3GI2 A;  3Q1H A;  1PD8 A;  1DAJ A;  3QYL A;  3QLX A;  4HOE A;  3ZPC A;  4XT6 A;  1DR5 A;  3FRA X;  1AO8 A;  2C2T A;  4KFJ A;  3KGY A;  1S3Y A;  4DPH A;  4X5H A;  1DDS A;  1S3W A;  1U72 A;  1DDR A;  1DHJ A;  1DR1 A;  6DFR A;  2XW7 A;  1DRB A;  2AZN A;  3GHC A;  3SRR X;  1JOM A;  1MVT A;  3ZPG A;  2HQP A;  1LY4 A;  3TD8 A;  3S3V A;  4QJZ D;  3IRO A;  3FQO A;  5HPB A;  1OHJ A;  4HOG A;  4P66 A;  3CD2 A;  3FS6 A;  5HT5 A;  3JW3 A;  3HJ3 A;  3FQV A;  2GD9 A;  3OAF A;  4KM0 A;  3S7A A;  1M78 A;  3QL0 A;  5ECC A;  4EIZ A;  1M79 A;  4M6L A;  4M2X A;  4DPD A;  3DL6 A;  5JA3 A;  4FHB A;  4G95 A;  5HF2 X;  4Q6A A;  3FQZ A;  3NZB X;  3ROA A;  3SA2 A;  3FRF X;  4ELF A;  4XT8 A;  1DLR A;  4XRB A;  1IA4 A;  4I1N A;  1KMV A;  1LY3 A;  3TQA A;  4I13 A;  3GHW A;  1D1G A;  1RA2 A;  3EEM A;  4LAG X;  3KFY A;  2ZZA A;  3F0V X;  2DHF A;  4PTJ A;  3D84 X;  1RX4 A;  3EEK A;  1RA3 A;  1CZ3 A;  3IA5 A;  4EIL A;  4M7U A;  4XT5 A;  3EEJ A; 
#chains in the Genus database with same CATH homology
 3R33 A;  1KLK A;  3K2H A;  1RH3 A;  2HM9 A;  1DYI A;  4P68 A;  3INV A;  2QK8 A;  4QHV A;  5HSU A;  1RB3 A;  2W9G A;  4P3R A;  3FY8 X;  3FQ0 A;  1DYR A;  4LAE X;  4KBN A;  4X5J A;  2G6V A;  1RD7 A;  3RO9 A;  1DRE A;  1DG5 A;  2O7P A;  2W3B A;  4PSS A;  1DLS A;  4X5I A;  3NXY A;  4OR7 A;  3F0U X;  4KEB A;  4KJJ A;  1DIS A;  1DYJ A;  2FZJ A;  4KAK A;  3DG8 A;  1DR3 A;  5HQY A;  3SA1 A;  4PSY A;  2JYB A;  1HFQ A;  4X5G A;  7DFR A;  3D80 A;  3F0Q X;  3JWF A;  3NXO A;  4ECK A;  5FDA A;  4NX7 A;  1LUD A;  3NU0 A;  1DRF A;  1IA1 A;  3SGY A;  4ELG A;  5JG0 X;  3VCO A;  3JTW A;  2D0K A;  5HQZ A;  5U27 A;  3QL3 A;  2W9S A;  3JW5 A;  3TQB A;  4EJ1 A;  2OIP A;  3OCH A;  1DG7 A;  1DR7 A;  2BLA A;  3QLY A;  3EEL A;  3GHV A;  3DL5 A;  3F91 A;  3EX8 A;  3JWM A;  4XE6 X;  3TQ8 A;  1HFR A;  3DGA A;  2H2Q A;  1DRA A;  3SRU X;  4DP3 A;  3QGT A;  3NXR A;  4PTH A;  4NX6 A;  2INQ A;  3HBB A;  2DRC A;  4GH8 A;  2CD2 A;  5EAJ A;  3NXX A;  3DAT A;  5DXV A;  3QLR A;  3KY8 A;  3NZD A;  3DFR A;  4H97 A;  5E8Q A;  1DR2 A;  2FZI A;  1BZF A;  1IA3 A;  3JWK A;  1J3I A;  5DFR A;  4PST A;  2W3W A;  2P4G A;  1OHK A;  1RX5 A;  3QLS A;  3QLW A;  4QLF A;  3QYO A;  3DRC A;  3SRW X;  4KJK A;  3UM5 A;  3E0B A;  4DFR A;  1RX3 A;  2HXV A;  1RA8 A;  3SR5 X;  1RX8 A;  8DFR A;  5CC9 A;  4QLG A;  1J3J A;  4KD7 A;  4HA7 A;  3TQ9 A;  4LEK X;  3LG4 A;  1DG8 A;  3QFX A;  3FYV X;  4ELB A;  4KY8 A;  3DAU A;  1QZF A;  2W9H A;  3FYW X;  4KJL A;  2D5N A;  1RF7 A;  1VJ3 A;  3SRQ X;  1ZDR A;  2BL9 A;  3IRN A;  4DDR A;  4HA9 A;  3SH2 A;  3M08 A;  3FQF A;  3QLZ A;  2OBC A;  3NZC X;  1U71 A;  1E26 A;  3IRM A;  3I3R A;  2C2S A;  3UM8 A;  4QJC A;  1DF7 A;  2BLB A;  3JVX A;  4XEC X;  4Q67 A;  2W9T A;  4TU5 X;  3NZ9 X;  2ANQ A;  1RX9 A;  4M6K A;  3SQY X;  1RG7 A;  1CD2 A;  1RA1 A;  1PDB A;  4QLE A;  2ANO A;  1JUV A;  1RX6 A;  5HUI A;  3NRR A;  1S3V A;  3K47 A;  1RX2 A;  3FY9 X;  3UM6 A;  4G8Z X;  2W3M A;  3FL9 A;  1DIU A;  5HSR A;  3CL9 A;  2FZH A;  3F0B X;  4M6J A;  4LAH X;  1M7A A;  5HVB A;  3F0X X;  3SAI A;  4H96 A;  4QI9 A;  3FRB X;  4IXG X;  4EIG A;  4HOF A;  4KL9 A;  3KJS A;  4G3M A;  4H95 A;  3FRD X;  3SRS X;  1DHI A;  4KM2 A;  1IA2 A;  3JWC A;  1DR6 A;  1DRH A;  1TDR A;  1S3U A;  5HVE A;  1DHF A;  1DYH A;  4RGC A;  3NXV A;  1SEJ A;  4ELH A;  3RG9 A;  3NZ6 X;  1RX7 A;  3GYF A;  3KJR A;  4KNE A;  5ECX A;  1VDR A;  2CIG A;  3NTZ A;  4FGG A;  5HF0 X;  4CD2 A;  1HFP A;  4IXF X;  5CCC A;  3CSE A;  1PD9 A;  3JSU A;  3FQC A;  1RA9 A;  3NZA X;  1DR4 A;  2BLC A;  3N0H A;  3F8Y A;  3F0S X;  4OSG A;  2W3A A;  4P3Q A;  5HT4 A;  5HI6 A;  1RB2 A;  1AOE A;  3NXT A;  3M09 A;  1RC4 A;  3I8A X;  1RX1 A;  4Q0E A;  4ELE A;  2L28 A;  2KGK A;  1JOL A;  1RE7 A;  4X5F A;  4IXE D;  3S9U A;  3FRE X;  1U70 A;  4XT4 A;  5U26 A;  3F8Z A;  3CLB A;  3L3R A;  1MVS A;  3EIG A;  4PDJ A;  4KLX A;  4M7V A;  3K45 A;  2LF1 A;  4KYA A;  3FL8 A;  3QG2 A;  3K74 A;  2B3Z A;  1YHO A;  2ITH A;  1BOZ A;  3IX9 A;  1AI9 A;  4FGH A;  4XT7 A;  2W3V A;  1J3K A;  1KMS A;  4Q0D A;  4KY4 A;  3IA4 A;  4H98 A;  3GI2 A;  3Q1H A;  1PD8 A;  1DAJ A;  3QYL A;  3QLX A;  4HOE A;  3ZPC A;  4XT6 A;  1DR5 A;  3FRA X;  1AO8 A;  2C2T A;  4KFJ A;  3KGY A;  1S3Y A;  4DPH A;  4X5H A;  1DDS A;  1S3W A;  1U72 A;  1DDR A;  1DHJ A;  1DR1 A;  6DFR A;  2XW7 A;  1DRB A;  2AZN A;  3GHC A;  3SRR X;  1JOM A;  1MVT A;  3ZPG A;  2HQP A;  1LY4 A;  3TD8 A;  3S3V A;  4QJZ D;  3IRO A;  3FQO A;  5HPB A;  1OHJ A;  4HOG A;  4P66 A;  3CD2 A;  3FS6 A;  5HT5 A;  3JW3 A;  3HJ3 A;  3FQV A;  2GD9 A;  3OAF A;  4KM0 A;  3S7A A;  1M78 A;  3QL0 A;  5ECC A;  4EIZ A;  1M79 A;  4M6L A;  4M2X A;  4DPD A;  3DL6 A;  5JA3 A;  4FHB A;  4G95 A;  5HF2 X;  4Q6A A;  3FQZ A;  3NZB X;  3ROA A;  3SA2 A;  3FRF X;  4ELF A;  4XT8 A;  1DLR A;  4XRB A;  1IA4 A;  4I1N A;  1KMV A;  1LY3 A;  3TQA A;  4I13 A;  3GHW A;  1D1G A;  1RA2 A;  3EEM A;  4LAG X;  3KFY A;  2ZZA A;  3F0V X;  2DHF A;  4PTJ A;  3D84 X;  1RX4 A;  3EEK A;  1RA3 A;  1CZ3 A;  3IA5 A;  4EIL A;  4M7U A;  4XT5 A;  3EEJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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