4KEBA

Human dihydrofolate reductase complexed with nadph and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimidine-2,4-diamine
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 54
structure length 186
sequence length 186
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-04-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4kebA00
4P66A 3NZDA 3TQAA 7DFRA 2W9TA 3M09A 4XT8A 2BLBA 1RX2A 1OHJA 3K45A 3D80A 2INQA 3QLYA 3SRQX 1DAJA 3EEJA 4X5GA 1RX4A 1U70A 2DHFA 1HFRA 3JW5A 4LEKX 3FRAX 4PTHA 3I8AX 4LAHX 3FQZA 2W3WA 1RD7A 3JSUA 3NZAX 1J3JA 4PTJA 3FRFX 1CD2A 1LUDA 1DR2A 1U71A 3NXRA 4ELFA 3TQ9A 4Q0EA 4HA9A 1DYRA 1DG7A 3E0BA 4LAGX 1DISA 3OCHA 4HOEA 3S7AA 3DGAA 3OAFA 5EAJA 1DR5A 3FYWX 3SQYX 3FQCA 4KAKA 1DR6A 1KMVA 1J3KA 1RG7A 1DHIA 3IRMA 4KJJA 3FRBX 5HF2X 4I13A 1DIUA 1RX1A 2G6VA 1RA1A 3QLXA 1DRHA 1PDBA 2ZZAA 4QI9A 1HFPA 2GD9A 3HBBA 4XT4A 3EELA 1DG5A 4GH8A 4G95A 2JYBA 1LY4A 1DR3A 3F0UX 1OHKA 4FHBA 4OR7A 3SRSX 1JOLA 3CSEA 8DFRA 4FGGA 1D1GA 1M7AA 4IXGX 3RO9A 1JUVA 4M6KA 3NRRA 4EIZA 3F8ZA 5U27A 2KGKA 4KL9A 3JTWA 4EIGA 2HXVA 1SEJA 4EJ1A 3F0BX 4P68A 1S3WA 4DDRA 3FY9X 3K47A 1QZFA 3IX9A 3IA5A 3F91A 2D0KA 2CD2A 3SRRX 3DL5A 4HA7A 2W3AA 2W9GA 4RGCA 4KM0A 3FQFA 1S3YA 3JWKA 1RX8A 4X5JA 3K74A 4XT6A 3NZBX 3SA1A 3GI2A 4KJKA 3FQOA 3ROAA 1IA2A 3JWMA 4M7UA 3SRWX 1DDRA 3NZ9X 3QFXA 1DYJA 3F8YA 1RC4A 1JOMA 3QYOA 3F0SX 3KJRA 1DYHA 2BLCA 4H96A 3UM8A 3TQ8A 5HQZA 4H97A 3QLRA 3QLWA 2H2QA 3ZPGA 1YHOA 5CC9A 4KY8A 2FZHA 3NXYA 3S9UA 1RB2A 2FZIA 4QJZD 3FS6A 3TD8A 3GHVA 5E8QA 3EX8A 1BOZA 4PSSA 1ZDRA 1DRAA 1RF7A 1DHFA 3GHWA 4H95A 3NXOA 4DPDA 3LG4A 2C2TA 3EEMA 4PSYA 3CL9A 3DFRA 3QLZA 3F0VX 3JW3A 4DPHA 1RX6A 3F0QX 5HI6A 4HOFA 1DG8A 2BL9A 2XW7A 3INVA 5JG0X 1DRFA 1RA8A 3R33A 4H98A 4KM2A 3KY8A 1CZ3A 3IROA 2W3VA 3GYFA 4ELHA 4NX6A 4I1NA 4Q67A 1RX7A 1RX3A 3S3VA 1M78A 5JA3A 3N0HA 4QJCA 3Q1HA 1DRBA 4PDJA 3FL9A 1RB3A 5DXVA 2W9HA 1VDRA 4DFRA 1AOEA 3QL3A 5HVBA 4KLXA 3QLSA 4XE6X 2QK8A 3NU0A 3QG2A 4XT5A 1VJ3A 1PD9A 1DLSA 5HQYA 3NXTA 3GHCA 1DDSA 4X5IA 2BLAA 1DF7A 5HSRA 1DYIA 1E26A 5HUIA 4KNEA 4P3RA 3FQVA 5HF0X 4ELBA 3FRDX 4M2XA 2LF1A 3JWFA 2B3ZA 3NZ6X 1DR1A 3D84X 4IXFX 4Q6AA 3HJ3A 1BZFA 5HT4A 1DR4A 5HVEA 4M6LA 3CLBA 4PSTA 3M08A 1DLRA 2W3MA 3KJSA 5HPBA 4NX7A 3FREX 1AO8A 3DG8A 4KD7A 4XRBA 5ECCA 2W3BA 3RG9A 2FZJA 3SH2A 1KMSA 4P3QA 3NXXA 4FGHA 3SRUX 2D5NA 3NXVA 3QGTA 4KJLA 4ELGA 2AZNA 3IRNA 4IXED 6DFRA 1RA9A 3EIGA 3UM5A 5HT5A 1MVTA 2CIGA 1M79A 4M7VA 1RE7A 1J3IA 5FDAA 1KLKA 3VCOA 2DRCA 4DP3A 3L3RA 3JVXA 4QLFA 1IA1A 4XT7A 4Q0DA 3SR5X 1IA4A 2P4GA 2L28A 1S3UA 3FQ0A 3TQBA 4KBNA 3EEKA 3FYVX 1U72A 2ANOA 1IA3A 4KFJA 1MVSA 2W9SA 1DREA 5CCCA 1PD8A 5HSUA 1RH3A 4X5HA 4HOGA 2ANQA 3FY8X 3DATA 2ITHA 4KYAA 3KFYA 4M6JA 4XECX 1AI9A 4G3MA 4CD2A 3K2HA 3FL8A 3DL6A 4TU5X 5ECXA 2OIPA 3UM6A 4EILA 3SA2A 2O7PA 2HM9A 1DHJA 3CD2A 4KEBA 3I3RA 3QYLA 4G8ZX 4X5FA 4QLEA 1DR7A 2C2SA 3SAIA 4KY4A 3DRCA 1S3VA 1RA2A 4LAEX 3IA4A 3QL0A 3KGYA 3NTZA 1HFQA 2HQPA 3DAUA 3NZCX 3JWCA 1RX5A 1LY3A 1RX9A 3F0XX 3ZPCA 4QLGA 5U26A 4ECKA 1TDRA 5DFRA 4OSGA 1RA3A 2OBCA 4ELEA 3SGYA 4QHVA
chains in the Genus database with same CATH superfamily
4P66A 3NZDA 3TQAA 7DFRA 2W9TA 3M09A 4XT8A 2BLBA 1RX2A 1OHJA 3K45A 3D80A 2INQA 3QLYA 3SRQX 1DAJA 3EEJA 4X5GA 1RX4A 1U70A 2DHFA 1HFRA 3JW5A 4LEKX 3FRAX 4PTHA 3I8AX 4LAHX 3FQZA 2W3WA 1RD7A 3JSUA 3NZAX 1J3JA 4PTJA 3FRFX 1CD2A 1LUDA 1DR2A 1U71A 3NXRA 4ELFA 3TQ9A 4Q0EA 4HA9A 1DYRA 1DG7A 3E0BA 4LAGX 1DISA 3OCHA 4HOEA 3S7AA 3DGAA 3OAFA 5EAJA 1DR5A 3FYWX 3SQYX 3FQCA 4KAKA 1DR6A 1KMVA 1J3KA 1RG7A 1DHIA 3IRMA 4KJJA 3FRBX 5HF2X 4I13A 1DIUA 1RX1A 2G6VA 1RA1A 3QLXA 1DRHA 1PDBA 2ZZAA 4QI9A 1HFPA 2GD9A 3HBBA 4XT4A 3EELA 1DG5A 4GH8A 4G95A 2JYBA 1LY4A 1DR3A 3F0UX 1OHKA 4FHBA 4OR7A 3SRSX 1JOLA 3CSEA 8DFRA 4FGGA 1D1GA 1M7AA 4IXGX 3RO9A 1JUVA 4M6KA 3NRRA 4EIZA 3F8ZA 5U27A 2KGKA 4KL9A 3JTWA 4EIGA 2HXVA 1SEJA 4EJ1A 3F0BX 4P68A 1S3WA 4DDRA 3FY9X 3K47A 1QZFA 3IX9A 3IA5A 3F91A 2D0KA 2CD2A 3SRRX 3DL5A 4HA7A 2W3AA 2W9GA 4RGCA 4KM0A 3FQFA 1S3YA 3JWKA 1RX8A 4X5JA 3K74A 4XT6A 3NZBX 3SA1A 3GI2A 4KJKA 3FQOA 3ROAA 1IA2A 3JWMA 4M7UA 3SRWX 1DDRA 3NZ9X 3QFXA 1DYJA 3F8YA 1RC4A 1JOMA 3QYOA 3F0SX 3KJRA 1DYHA 2BLCA 4H96A 3UM8A 3TQ8A 5HQZA 4H97A 3QLRA 3QLWA 2H2QA 3ZPGA 1YHOA 5CC9A 4KY8A 2FZHA 3NXYA 3S9UA 1RB2A 2FZIA 4QJZD 3FS6A 3TD8A 3GHVA 5E8QA 3EX8A 1BOZA 4PSSA 1ZDRA 1DRAA 1RF7A 1DHFA 3GHWA 4H95A 3NXOA 4DPDA 3LG4A 2C2TA 3EEMA 4PSYA 3CL9A 3DFRA 3QLZA 3F0VX 3JW3A 4DPHA 1RX6A 3F0QX 5HI6A 4HOFA 1DG8A 2BL9A 2XW7A 3INVA 5JG0X 1DRFA 1RA8A 3R33A 4H98A 4KM2A 3KY8A 1CZ3A 3IROA 2W3VA 3GYFA 4ELHA 4NX6A 4I1NA 4Q67A 1RX7A 1RX3A 3S3VA 1M78A 5JA3A 3N0HA 4QJCA 3Q1HA 1DRBA 4PDJA 3FL9A 1RB3A 5DXVA 2W9HA 1VDRA 4DFRA 1AOEA 3QL3A 5HVBA 4KLXA 3QLSA 4XE6X 2QK8A 3NU0A 3QG2A 4XT5A 1VJ3A 1PD9A 1DLSA 5HQYA 3NXTA 3GHCA 1DDSA 4X5IA 2BLAA 1DF7A 5HSRA 1DYIA 1E26A 5HUIA 4KNEA 4P3RA 3FQVA 5HF0X 4ELBA 3FRDX 4M2XA 2LF1A 3JWFA 2B3ZA 3NZ6X 1DR1A 3D84X 4IXFX 4Q6AA 3HJ3A 1BZFA 5HT4A 1DR4A 5HVEA 4M6LA 3CLBA 4PSTA 3M08A 1DLRA 2W3MA 3KJSA 5HPBA 4NX7A 3FREX 1AO8A 3DG8A 4KD7A 4XRBA 5ECCA 2W3BA 3RG9A 2FZJA 3SH2A 1KMSA 4P3QA 3NXXA 4FGHA 3SRUX 2D5NA 3NXVA 3QGTA 4KJLA 4ELGA 2AZNA 3IRNA 4IXED 6DFRA 1RA9A 3EIGA 3UM5A 5HT5A 1MVTA 2CIGA 1M79A 4M7VA 1RE7A 1J3IA 5FDAA 1KLKA 3VCOA 2DRCA 4DP3A 3L3RA 3JVXA 4QLFA 1IA1A 4XT7A 4Q0DA 3SR5X 1IA4A 2P4GA 2L28A 1S3UA 3FQ0A 3TQBA 4KBNA 3EEKA 3FYVX 1U72A 2ANOA 1IA3A 4KFJA 1MVSA 2W9SA 1DREA 5CCCA 1PD8A 5HSUA 1RH3A 4X5HA 4HOGA 2ANQA 3FY8X 3DATA 2ITHA 4KYAA 3KFYA 4M6JA 4XECX 1AI9A 4G3MA 4CD2A 3K2HA 3FL8A 3DL6A 4TU5X 5ECXA 2OIPA 3UM6A 4EILA 3SA2A 2O7PA 2HM9A 1DHJA 3CD2A 4KEBA 3I3RA 3QYLA 4G8ZX 4X5FA 4QLEA 1DR7A 2C2SA 3SAIA 4KY4A 3DRCA 1S3VA 1RA2A 4LAEX 3IA4A 3QL0A 3KGYA 3NTZA 1HFQA 2HQPA 3DAUA 3NZCX 3JWCA 1RX5A 1LY3A 1RX9A 3F0XX 3ZPCA 4QLGA 5U26A 4ECKA 1TDRA 5DFRA 4OSGA 1RA3A 2OBCA 4ELEA 3SGYA 4QHVA
chains in the Genus database with same CATH topology
4P66A 3NZDA 3TQAA 7DFRA 2W9TA 3M09A 4XT8A 2BLBA 1RX2A 1OHJA 3K45A 3D80A 2INQA 3QLYA 3SRQX 1DAJA 3EEJA 4X5GA 1RX4A 1U70A 2DHFA 1HFRA 3JW5A 4LEKX 3FRAX 4PTHA 3I8AX 4LAHX 3FQZA 2W3WA 1RD7A 3JSUA 3NZAX 1J3JA 4PTJA 3FRFX 1CD2A 1LUDA 1DR2A 1U71A 3NXRA 4ELFA 3TQ9A 4Q0EA 4HA9A 1DYRA 1DG7A 3E0BA 4LAGX 1DISA 3OCHA 4HOEA 3S7AA 3DGAA 3OAFA 5EAJA 1DR5A 3FYWX 3SQYX 3FQCA 4KAKA 1DR6A 1KMVA 1J3KA 1RG7A 1DHIA 3IRMA 4KJJA 3FRBX 5HF2X 4I13A 1DIUA 1RX1A 2G6VA 1RA1A 3QLXA 1DRHA 1PDBA 2ZZAA 4QI9A 1HFPA 2GD9A 3HBBA 4XT4A 3EELA 1DG5A 4GH8A 4G95A 2JYBA 1LY4A 1DR3A 3F0UX 1OHKA 4FHBA 4OR7A 3SRSX 1JOLA 3CSEA 8DFRA 4FGGA 1D1GA 1M7AA 4IXGX 3RO9A 1JUVA 4M6KA 3NRRA 4EIZA 3F8ZA 5U27A 2KGKA 4KL9A 3JTWA 4EIGA 2HXVA 1SEJA 4EJ1A 3F0BX 4P68A 1S3WA 4DDRA 3FY9X 3K47A 1QZFA 3IX9A 3IA5A 3F91A 2D0KA 2CD2A 3SRRX 3DL5A 4HA7A 2W3AA 2W9GA 4RGCA 4KM0A 3FQFA 1S3YA 3JWKA 1RX8A 4X5JA 3K74A 4XT6A 3NZBX 3SA1A 3GI2A 4KJKA 3FQOA 3ROAA 1IA2A 3JWMA 4M7UA 3SRWX 1DDRA 3NZ9X 3QFXA 1DYJA 3F8YA 1RC4A 1JOMA 3QYOA 3F0SX 3KJRA 1DYHA 2BLCA 4H96A 3UM8A 3TQ8A 5HQZA 4H97A 3QLRA 3QLWA 2H2QA 3ZPGA 1YHOA 5CC9A 4KY8A 2FZHA 3NXYA 3S9UA 1RB2A 2FZIA 4QJZD 3FS6A 3TD8A 3GHVA 5E8QA 3EX8A 1BOZA 4PSSA 1ZDRA 1DRAA 1RF7A 1DHFA 3GHWA 4H95A 3NXOA 4DPDA 3LG4A 2C2TA 3EEMA 4PSYA 3CL9A 3DFRA 3QLZA 3F0VX 3JW3A 4DPHA 1RX6A 3F0QX 5HI6A 4HOFA 1DG8A 2BL9A 2XW7A 3INVA 5JG0X 1DRFA 1RA8A 3R33A 4H98A 4KM2A 3KY8A 1CZ3A 3IROA 2W3VA 3GYFA 4ELHA 4NX6A 4I1NA 4Q67A 1RX7A 1RX3A 3S3VA 1M78A 5JA3A 3N0HA 4QJCA 3Q1HA 1DRBA 4PDJA 3FL9A 1RB3A 5DXVA 2W9HA 1VDRA 4DFRA 1AOEA 3QL3A 5HVBA 4KLXA 3QLSA 4XE6X 2QK8A 3NU0A 3QG2A 4XT5A 1VJ3A 1PD9A 1DLSA 5HQYA 3NXTA 3GHCA 1DDSA 4X5IA 2BLAA 1DF7A 5HSRA 1DYIA 1E26A 5HUIA 4KNEA 4P3RA 3FQVA 5HF0X 4ELBA 3FRDX 4M2XA 2LF1A 3JWFA 2B3ZA 3NZ6X 1DR1A 3D84X 4IXFX 4Q6AA 3HJ3A 1BZFA 5HT4A 1DR4A 5HVEA 4M6LA 3CLBA 4PSTA 3M08A 1DLRA 2W3MA 3KJSA 5HPBA 4NX7A 3FREX 1AO8A 3DG8A 4KD7A 4XRBA 5ECCA 2W3BA 3RG9A 2FZJA 3SH2A 1KMSA 4P3QA 3NXXA 4FGHA 3SRUX 2D5NA 3NXVA 3QGTA 4KJLA 4ELGA 2AZNA 3IRNA 4IXED 6DFRA 1RA9A 3EIGA 3UM5A 5HT5A 1MVTA 2CIGA 1M79A 4M7VA 1RE7A 1J3IA 5FDAA 1KLKA 3VCOA 2DRCA 4DP3A 3L3RA 3JVXA 4QLFA 1IA1A 4XT7A 4Q0DA 3SR5X 1IA4A 2P4GA 2L28A 1S3UA 3FQ0A 3TQBA 4KBNA 3EEKA 3FYVX 1U72A 2ANOA 1IA3A 4KFJA 1MVSA 2W9SA 1DREA 5CCCA 1PD8A 5HSUA 1RH3A 4X5HA 4HOGA 2ANQA 3FY8X 3DATA 2ITHA 4KYAA 3KFYA 4M6JA 4XECX 1AI9A 4G3MA 4CD2A 3K2HA 3FL8A 3DL6A 4TU5X 5ECXA 2OIPA 3UM6A 4EILA 3SA2A 2O7PA 2HM9A 1DHJA 3CD2A 4KEBA 3I3RA 3QYLA 4G8ZX 4X5FA 4QLEA 1DR7A 2C2SA 3SAIA 4KY4A 3DRCA 1S3VA 1RA2A 4LAEX 3IA4A 3QL0A 3KGYA 3NTZA 1HFQA 2HQPA 3DAUA 3NZCX 3JWCA 1RX5A 1LY3A 1RX9A 3F0XX 3ZPCA 4QLGA 5U26A 4ECKA 1TDRA 5DFRA 4OSGA 1RA3A 2OBCA 4ELEA 3SGYA 4QHVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4P66 A;  3NZD A;  3TQA A;  7DFR A;  2W9T A;  3M09 A;  4XT8 A;  2BLB A;  1RX2 A;  1OHJ A;  3K45 A;  3D80 A;  2INQ A;  3QLY A;  3SRQ X;  1DAJ A;  3EEJ A;  4X5G A;  1RX4 A;  1U70 A;  2DHF A;  1HFR A;  3JW5 A;  4LEK X;  3FRA X;  4PTH A;  3I8A X;  4LAH X;  3FQZ A;  2W3W A;  1RD7 A;  3JSU A;  3NZA X;  1J3J A;  4PTJ A;  3FRF X;  1CD2 A;  1LUD A;  1DR2 A;  1U71 A;  3NXR A;  4ELF A;  3TQ9 A;  4Q0E A;  4HA9 A;  1DYR A;  1DG7 A;  3E0B A;  4LAG X;  1DIS A;  3OCH A;  4HOE A;  3S7A A;  3DGA A;  3OAF A;  5EAJ A;  1DR5 A;  3FYW X;  3SQY X;  3FQC A;  4KAK A;  1DR6 A;  1KMV A;  1J3K A;  1RG7 A;  1DHI A;  3IRM A;  4KJJ A;  3FRB X;  5HF2 X;  4I13 A;  1DIU A;  1RX1 A;  2G6V A;  1RA1 A;  3QLX A;  1DRH A;  1PDB A;  2ZZA A;  4QI9 A;  1HFP A;  2GD9 A;  3HBB A;  4XT4 A;  3EEL A;  1DG5 A;  4GH8 A;  4G95 A;  2JYB A;  1LY4 A;  1DR3 A;  3F0U X;  1OHK A;  4FHB A;  4OR7 A;  3SRS X;  1JOL A;  3CSE A;  8DFR A;  4FGG A;  1D1G A;  1M7A A;  4IXG X;  3RO9 A;  1JUV A;  4M6K A;  3NRR A;  4EIZ A;  3F8Z A;  5U27 A;  2KGK A;  4KL9 A;  3JTW A;  4EIG A;  2HXV A;  1SEJ A;  4EJ1 A;  3F0B X;  4P68 A;  1S3W A;  4DDR A;  3FY9 X;  3K47 A;  1QZF A;  3IX9 A;  3IA5 A;  3F91 A;  2D0K A;  2CD2 A;  3SRR X;  3DL5 A;  4HA7 A;  2W3A A;  2W9G A;  4RGC A;  4KM0 A;  3FQF A;  1S3Y A;  3JWK A;  1RX8 A;  4X5J A;  3K74 A;  4XT6 A;  3NZB X;  3SA1 A;  3GI2 A;  4KJK A;  3FQO A;  3ROA A;  1IA2 A;  3JWM A;  4M7U A;  3SRW X;  1DDR A;  3NZ9 X;  3QFX A;  1DYJ A;  3F8Y A;  1RC4 A;  1JOM A;  3QYO A;  3F0S X;  3KJR A;  1DYH A;  2BLC A;  4H96 A;  3UM8 A;  3TQ8 A;  5HQZ A;  4H97 A;  3QLR A;  3QLW A;  2H2Q A;  3ZPG A;  1YHO A;  5CC9 A;  4KY8 A;  2FZH A;  3NXY A;  3S9U A;  1RB2 A;  2FZI A;  4QJZ D;  3FS6 A;  3TD8 A;  3GHV A;  5E8Q A;  3EX8 A;  1BOZ A;  4PSS A;  1ZDR A;  1DRA A;  1RF7 A;  1DHF A;  3GHW A;  4H95 A;  3NXO A;  4DPD A;  3LG4 A;  2C2T A;  3EEM A;  4PSY A;  3CL9 A;  3DFR A;  3QLZ A;  3F0V X;  3JW3 A;  4DPH A;  1RX6 A;  3F0Q X;  5HI6 A;  4HOF A;  1DG8 A;  2BL9 A;  2XW7 A;  3INV A;  5JG0 X;  1DRF A;  1RA8 A;  3R33 A;  4H98 A;  4KM2 A;  3KY8 A;  1CZ3 A;  3IRO A;  2W3V A;  3GYF A;  4ELH A;  4NX6 A;  4I1N A;  4Q67 A;  1RX7 A;  1RX3 A;  3S3V A;  1M78 A;  5JA3 A;  3N0H A;  4QJC A;  3Q1H A;  1DRB A;  4PDJ A;  3FL9 A;  1RB3 A;  5DXV A;  2W9H A;  1VDR A;  4DFR A;  1AOE A;  3QL3 A;  5HVB A;  4KLX A;  3QLS A;  4XE6 X;  2QK8 A;  3NU0 A;  3QG2 A;  4XT5 A;  1VJ3 A;  1PD9 A;  1DLS A;  5HQY A;  3NXT A;  3GHC A;  1DDS A;  4X5I A;  2BLA A;  1DF7 A;  5HSR A;  1DYI A;  1E26 A;  5HUI A;  4KNE A;  4P3R A;  3FQV A;  5HF0 X;  4ELB A;  3FRD X;  4M2X A;  2LF1 A;  3JWF A;  2B3Z A;  3NZ6 X;  1DR1 A;  3D84 X;  4IXF X;  4Q6A A;  3HJ3 A;  1BZF A;  5HT4 A;  1DR4 A;  5HVE A;  4M6L A;  3CLB A;  4PST A;  3M08 A;  1DLR A;  2W3M A;  3KJS A;  5HPB A;  4NX7 A;  3FRE X;  1AO8 A;  3DG8 A;  4KD7 A;  4XRB A;  5ECC A;  2W3B A;  3RG9 A;  2FZJ A;  3SH2 A;  1KMS A;  4P3Q A;  3NXX A;  4FGH A;  3SRU X;  2D5N A;  3NXV A;  3QGT A;  4KJL A;  4ELG A;  2AZN A;  3IRN A;  4IXE D;  6DFR A;  1RA9 A;  3EIG A;  3UM5 A;  5HT5 A;  1MVT A;  2CIG A;  1M79 A;  4M7V A;  1RE7 A;  1J3I A;  5FDA A;  1KLK A;  3VCO A;  2DRC A;  4DP3 A;  3L3R A;  3JVX A;  4QLF A;  1IA1 A;  4XT7 A;  4Q0D A;  3SR5 X;  1IA4 A;  2P4G A;  2L28 A;  1S3U A;  3FQ0 A;  3TQB A;  4KBN A;  3EEK A;  3FYV X;  1U72 A;  2ANO A;  1IA3 A;  4KFJ A;  1MVS A;  2W9S A;  1DRE A;  5CCC A;  1PD8 A;  5HSU A;  1RH3 A;  4X5H A;  4HOG A;  2ANQ A;  3FY8 X;  3DAT A;  2ITH A;  4KYA A;  3KFY A;  4M6J A;  4XEC X;  1AI9 A;  4G3M A;  4CD2 A;  3K2H A;  3FL8 A;  3DL6 A;  4TU5 X;  5ECX A;  2OIP A;  3UM6 A;  4EIL A;  3SA2 A;  2O7P A;  2HM9 A;  1DHJ A;  3CD2 A;  4KEB A;  3I3R A;  3QYL A;  4G8Z X;  4X5F A;  4QLE A;  1DR7 A;  2C2S A;  3SAI A;  4KY4 A;  3DRC A;  1S3V A;  1RA2 A;  4LAE X;  3IA4 A;  3QL0 A;  3KGY A;  3NTZ A;  1HFQ A;  2HQP A;  3DAU A;  3NZC X;  3JWC A;  1RX5 A;  1LY3 A;  1RX9 A;  3F0X X;  3ZPC A;  4QLG A;  5U26 A;  4ECK A;  1TDR A;  5DFR A;  4OSG A;  1RA3 A;  2OBC A;  4ELE A;  3SGY A;  4QHV A; 
#chains in the Genus database with same CATH topology
 4P66 A;  3NZD A;  3TQA A;  7DFR A;  2W9T A;  3M09 A;  4XT8 A;  2BLB A;  1RX2 A;  1OHJ A;  3K45 A;  3D80 A;  2INQ A;  3QLY A;  3SRQ X;  1DAJ A;  3EEJ A;  4X5G A;  1RX4 A;  1U70 A;  2DHF A;  1HFR A;  3JW5 A;  4LEK X;  3FRA X;  4PTH A;  3I8A X;  4LAH X;  3FQZ A;  2W3W A;  1RD7 A;  3JSU A;  3NZA X;  1J3J A;  4PTJ A;  3FRF X;  1CD2 A;  1LUD A;  1DR2 A;  1U71 A;  3NXR A;  4ELF A;  3TQ9 A;  4Q0E A;  4HA9 A;  1DYR A;  1DG7 A;  3E0B A;  4LAG X;  1DIS A;  3OCH A;  4HOE A;  3S7A A;  3DGA A;  3OAF A;  5EAJ A;  1DR5 A;  3FYW X;  3SQY X;  3FQC A;  4KAK A;  1DR6 A;  1KMV A;  1J3K A;  1RG7 A;  1DHI A;  3IRM A;  4KJJ A;  3FRB X;  5HF2 X;  4I13 A;  1DIU A;  1RX1 A;  2G6V A;  1RA1 A;  3QLX A;  1DRH A;  1PDB A;  2ZZA A;  4QI9 A;  1HFP A;  2GD9 A;  3HBB A;  4XT4 A;  3EEL A;  1DG5 A;  4GH8 A;  4G95 A;  2JYB A;  1LY4 A;  1DR3 A;  3F0U X;  1OHK A;  4FHB A;  4OR7 A;  3SRS X;  1JOL A;  3CSE A;  8DFR A;  4FGG A;  1D1G A;  1M7A A;  4IXG X;  3RO9 A;  1JUV A;  4M6K A;  3NRR A;  4EIZ A;  3F8Z A;  5U27 A;  2KGK A;  4KL9 A;  3JTW A;  4EIG A;  2HXV A;  1SEJ A;  4EJ1 A;  3F0B X;  4P68 A;  1S3W A;  4DDR A;  3FY9 X;  3K47 A;  1QZF A;  3IX9 A;  3IA5 A;  3F91 A;  2D0K A;  2CD2 A;  3SRR X;  3DL5 A;  4HA7 A;  2W3A A;  2W9G A;  4RGC A;  4KM0 A;  3FQF A;  1S3Y A;  3JWK A;  1RX8 A;  4X5J A;  3K74 A;  4XT6 A;  3NZB X;  3SA1 A;  3GI2 A;  4KJK A;  3FQO A;  3ROA A;  1IA2 A;  3JWM A;  4M7U A;  3SRW X;  1DDR A;  3NZ9 X;  3QFX A;  1DYJ A;  3F8Y A;  1RC4 A;  1JOM A;  3QYO A;  3F0S X;  3KJR A;  1DYH A;  2BLC A;  4H96 A;  3UM8 A;  3TQ8 A;  5HQZ A;  4H97 A;  3QLR A;  3QLW A;  2H2Q A;  3ZPG A;  1YHO A;  5CC9 A;  4KY8 A;  2FZH A;  3NXY A;  3S9U A;  1RB2 A;  2FZI A;  4QJZ D;  3FS6 A;  3TD8 A;  3GHV A;  5E8Q A;  3EX8 A;  1BOZ A;  4PSS A;  1ZDR A;  1DRA A;  1RF7 A;  1DHF A;  3GHW A;  4H95 A;  3NXO A;  4DPD A;  3LG4 A;  2C2T A;  3EEM A;  4PSY A;  3CL9 A;  3DFR A;  3QLZ A;  3F0V X;  3JW3 A;  4DPH A;  1RX6 A;  3F0Q X;  5HI6 A;  4HOF A;  1DG8 A;  2BL9 A;  2XW7 A;  3INV A;  5JG0 X;  1DRF A;  1RA8 A;  3R33 A;  4H98 A;  4KM2 A;  3KY8 A;  1CZ3 A;  3IRO A;  2W3V A;  3GYF A;  4ELH A;  4NX6 A;  4I1N A;  4Q67 A;  1RX7 A;  1RX3 A;  3S3V A;  1M78 A;  5JA3 A;  3N0H A;  4QJC A;  3Q1H A;  1DRB A;  4PDJ A;  3FL9 A;  1RB3 A;  5DXV A;  2W9H A;  1VDR A;  4DFR A;  1AOE A;  3QL3 A;  5HVB A;  4KLX A;  3QLS A;  4XE6 X;  2QK8 A;  3NU0 A;  3QG2 A;  4XT5 A;  1VJ3 A;  1PD9 A;  1DLS A;  5HQY A;  3NXT A;  3GHC A;  1DDS A;  4X5I A;  2BLA A;  1DF7 A;  5HSR A;  1DYI A;  1E26 A;  5HUI A;  4KNE A;  4P3R A;  3FQV A;  5HF0 X;  4ELB A;  3FRD X;  4M2X A;  2LF1 A;  3JWF A;  2B3Z A;  3NZ6 X;  1DR1 A;  3D84 X;  4IXF X;  4Q6A A;  3HJ3 A;  1BZF A;  5HT4 A;  1DR4 A;  5HVE A;  4M6L A;  3CLB A;  4PST A;  3M08 A;  1DLR A;  2W3M A;  3KJS A;  5HPB A;  4NX7 A;  3FRE X;  1AO8 A;  3DG8 A;  4KD7 A;  4XRB A;  5ECC A;  2W3B A;  3RG9 A;  2FZJ A;  3SH2 A;  1KMS A;  4P3Q A;  3NXX A;  4FGH A;  3SRU X;  2D5N A;  3NXV A;  3QGT A;  4KJL A;  4ELG A;  2AZN A;  3IRN A;  4IXE D;  6DFR A;  1RA9 A;  3EIG A;  3UM5 A;  5HT5 A;  1MVT A;  2CIG A;  1M79 A;  4M7V A;  1RE7 A;  1J3I A;  5FDA A;  1KLK A;  3VCO A;  2DRC A;  4DP3 A;  3L3R A;  3JVX A;  4QLF A;  1IA1 A;  4XT7 A;  4Q0D A;  3SR5 X;  1IA4 A;  2P4G A;  2L28 A;  1S3U A;  3FQ0 A;  3TQB A;  4KBN A;  3EEK A;  3FYV X;  1U72 A;  2ANO A;  1IA3 A;  4KFJ A;  1MVS A;  2W9S A;  1DRE A;  5CCC A;  1PD8 A;  5HSU A;  1RH3 A;  4X5H A;  4HOG A;  2ANQ A;  3FY8 X;  3DAT A;  2ITH A;  4KYA A;  3KFY A;  4M6J A;  4XEC X;  1AI9 A;  4G3M A;  4CD2 A;  3K2H A;  3FL8 A;  3DL6 A;  4TU5 X;  5ECX A;  2OIP A;  3UM6 A;  4EIL A;  3SA2 A;  2O7P A;  2HM9 A;  1DHJ A;  3CD2 A;  4KEB A;  3I3R A;  3QYL A;  4G8Z X;  4X5F A;  4QLE A;  1DR7 A;  2C2S A;  3SAI A;  4KY4 A;  3DRC A;  1S3V A;  1RA2 A;  4LAE X;  3IA4 A;  3QL0 A;  3KGY A;  3NTZ A;  1HFQ A;  2HQP A;  3DAU A;  3NZC X;  3JWC A;  1RX5 A;  1LY3 A;  1RX9 A;  3F0X X;  3ZPC A;  4QLG A;  5U26 A;  4ECK A;  1TDR A;  5DFR A;  4OSG A;  1RA3 A;  2OBC A;  4ELE A;  3SGY A;  4QHV A; 
#chains in the Genus database with same CATH homology
 4P66 A;  3NZD A;  3TQA A;  7DFR A;  2W9T A;  3M09 A;  4XT8 A;  2BLB A;  1RX2 A;  1OHJ A;  3K45 A;  3D80 A;  2INQ A;  3QLY A;  3SRQ X;  1DAJ A;  3EEJ A;  4X5G A;  1RX4 A;  1U70 A;  2DHF A;  1HFR A;  3JW5 A;  4LEK X;  3FRA X;  4PTH A;  3I8A X;  4LAH X;  3FQZ A;  2W3W A;  1RD7 A;  3JSU A;  3NZA X;  1J3J A;  4PTJ A;  3FRF X;  1CD2 A;  1LUD A;  1DR2 A;  1U71 A;  3NXR A;  4ELF A;  3TQ9 A;  4Q0E A;  4HA9 A;  1DYR A;  1DG7 A;  3E0B A;  4LAG X;  1DIS A;  3OCH A;  4HOE A;  3S7A A;  3DGA A;  3OAF A;  5EAJ A;  1DR5 A;  3FYW X;  3SQY X;  3FQC A;  4KAK A;  1DR6 A;  1KMV A;  1J3K A;  1RG7 A;  1DHI A;  3IRM A;  4KJJ A;  3FRB X;  5HF2 X;  4I13 A;  1DIU A;  1RX1 A;  2G6V A;  1RA1 A;  3QLX A;  1DRH A;  1PDB A;  2ZZA A;  4QI9 A;  1HFP A;  2GD9 A;  3HBB A;  4XT4 A;  3EEL A;  1DG5 A;  4GH8 A;  4G95 A;  2JYB A;  1LY4 A;  1DR3 A;  3F0U X;  1OHK A;  4FHB A;  4OR7 A;  3SRS X;  1JOL A;  3CSE A;  8DFR A;  4FGG A;  1D1G A;  1M7A A;  4IXG X;  3RO9 A;  1JUV A;  4M6K A;  3NRR A;  4EIZ A;  3F8Z A;  5U27 A;  2KGK A;  4KL9 A;  3JTW A;  4EIG A;  2HXV A;  1SEJ A;  4EJ1 A;  3F0B X;  4P68 A;  1S3W A;  4DDR A;  3FY9 X;  3K47 A;  1QZF A;  3IX9 A;  3IA5 A;  3F91 A;  2D0K A;  2CD2 A;  3SRR X;  3DL5 A;  4HA7 A;  2W3A A;  2W9G A;  4RGC A;  4KM0 A;  3FQF A;  1S3Y A;  3JWK A;  1RX8 A;  4X5J A;  3K74 A;  4XT6 A;  3NZB X;  3SA1 A;  3GI2 A;  4KJK A;  3FQO A;  3ROA A;  1IA2 A;  3JWM A;  4M7U A;  3SRW X;  1DDR A;  3NZ9 X;  3QFX A;  1DYJ A;  3F8Y A;  1RC4 A;  1JOM A;  3QYO A;  3F0S X;  3KJR A;  1DYH A;  2BLC A;  4H96 A;  3UM8 A;  3TQ8 A;  5HQZ A;  4H97 A;  3QLR A;  3QLW A;  2H2Q A;  3ZPG A;  1YHO A;  5CC9 A;  4KY8 A;  2FZH A;  3NXY A;  3S9U A;  1RB2 A;  2FZI A;  4QJZ D;  3FS6 A;  3TD8 A;  3GHV A;  5E8Q A;  3EX8 A;  1BOZ A;  4PSS A;  1ZDR A;  1DRA A;  1RF7 A;  1DHF A;  3GHW A;  4H95 A;  3NXO A;  4DPD A;  3LG4 A;  2C2T A;  3EEM A;  4PSY A;  3CL9 A;  3DFR A;  3QLZ A;  3F0V X;  3JW3 A;  4DPH A;  1RX6 A;  3F0Q X;  5HI6 A;  4HOF A;  1DG8 A;  2BL9 A;  2XW7 A;  3INV A;  5JG0 X;  1DRF A;  1RA8 A;  3R33 A;  4H98 A;  4KM2 A;  3KY8 A;  1CZ3 A;  3IRO A;  2W3V A;  3GYF A;  4ELH A;  4NX6 A;  4I1N A;  4Q67 A;  1RX7 A;  1RX3 A;  3S3V A;  1M78 A;  5JA3 A;  3N0H A;  4QJC A;  3Q1H A;  1DRB A;  4PDJ A;  3FL9 A;  1RB3 A;  5DXV A;  2W9H A;  1VDR A;  4DFR A;  1AOE A;  3QL3 A;  5HVB A;  4KLX A;  3QLS A;  4XE6 X;  2QK8 A;  3NU0 A;  3QG2 A;  4XT5 A;  1VJ3 A;  1PD9 A;  1DLS A;  5HQY A;  3NXT A;  3GHC A;  1DDS A;  4X5I A;  2BLA A;  1DF7 A;  5HSR A;  1DYI A;  1E26 A;  5HUI A;  4KNE A;  4P3R A;  3FQV A;  5HF0 X;  4ELB A;  3FRD X;  4M2X A;  2LF1 A;  3JWF A;  2B3Z A;  3NZ6 X;  1DR1 A;  3D84 X;  4IXF X;  4Q6A A;  3HJ3 A;  1BZF A;  5HT4 A;  1DR4 A;  5HVE A;  4M6L A;  3CLB A;  4PST A;  3M08 A;  1DLR A;  2W3M A;  3KJS A;  5HPB A;  4NX7 A;  3FRE X;  1AO8 A;  3DG8 A;  4KD7 A;  4XRB A;  5ECC A;  2W3B A;  3RG9 A;  2FZJ A;  3SH2 A;  1KMS A;  4P3Q A;  3NXX A;  4FGH A;  3SRU X;  2D5N A;  3NXV A;  3QGT A;  4KJL A;  4ELG A;  2AZN A;  3IRN A;  4IXE D;  6DFR A;  1RA9 A;  3EIG A;  3UM5 A;  5HT5 A;  1MVT A;  2CIG A;  1M79 A;  4M7V A;  1RE7 A;  1J3I A;  5FDA A;  1KLK A;  3VCO A;  2DRC A;  4DP3 A;  3L3R A;  3JVX A;  4QLF A;  1IA1 A;  4XT7 A;  4Q0D A;  3SR5 X;  1IA4 A;  2P4G A;  2L28 A;  1S3U A;  3FQ0 A;  3TQB A;  4KBN A;  3EEK A;  3FYV X;  1U72 A;  2ANO A;  1IA3 A;  4KFJ A;  1MVS A;  2W9S A;  1DRE A;  5CCC A;  1PD8 A;  5HSU A;  1RH3 A;  4X5H A;  4HOG A;  2ANQ A;  3FY8 X;  3DAT A;  2ITH A;  4KYA A;  3KFY A;  4M6J A;  4XEC X;  1AI9 A;  4G3M A;  4CD2 A;  3K2H A;  3FL8 A;  3DL6 A;  4TU5 X;  5ECX A;  2OIP A;  3UM6 A;  4EIL A;  3SA2 A;  2O7P A;  2HM9 A;  1DHJ A;  3CD2 A;  4KEB A;  3I3R A;  3QYL A;  4G8Z X;  4X5F A;  4QLE A;  1DR7 A;  2C2S A;  3SAI A;  4KY4 A;  3DRC A;  1S3V A;  1RA2 A;  4LAE X;  3IA4 A;  3QL0 A;  3KGY A;  3NTZ A;  1HFQ A;  2HQP A;  3DAU A;  3NZC X;  3JWC A;  1RX5 A;  1LY3 A;  1RX9 A;  3F0X X;  3ZPC A;  4QLG A;  5U26 A;  4ECK A;  1TDR A;  5DFR A;  4OSG A;  1RA3 A;  2OBC A;  4ELE A;  3SGY A;  4QHV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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