4KFJA

Human dihydrofolate reductase complexed with nadph and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]prop-1-yn-1-yl}6-ethylprimidine-2,4-diamine
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 53
structure length 186
sequence length 186
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-04-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4kfjA00
3NZBX 2ZZAA 3JWMA 1PD8A 3GI2A 1JUVA 3FRDX 1PD9A 3M09A 1DR2A 3FL8A 3HBBA 1DR3A 4KYAA 4GH8A 3F8ZA 4QI9A 4X5HA 1RX6A 4LAGX 4IXGX 3JSUA 3FQFA 1TDRA 1IA4A 1RX7A 3ZPGA 2FZHA 3I8AX 3FY9X 3QLSA 3JVXA 3CSEA 3DAUA 3R33A 3RO9A 4XT6A 4Q6AA 1JOMA 3SRUX 3E0BA 3TQ8A 1LUDA 3IX9A 3NZCX 3N0HA 4M7VA 1M7AA 1IA3A 1RA8A 4PSTA 3UM8A 3IRNA 4KNEA 4H97A 4KM0A 1VDRA 3EELA 1DREA 3QGTA 3TQBA 3IRMA 1J3KA 1DF7A 1S3YA 3JWCA 1RD7A 4EJ1A 5HSUA 4PTHA 2JYBA 3QLXA 5HI6A 1RA1A 3LG4A 3JWFA 2BL9A 4P3RA 4DDRA 3FYVX 3GHWA 3F0XX 1IA1A 3QL0A 4ELGA 4DP3A 3D84X 4HOGA 4P68A 2FZJA 2OBCA 1DHIA 2W3VA 4FGHA 4ELEA 3K74A 2D5NA 3NXVA 1RB2A 4PTJA 4OSGA 3JW3A 3INVA 4I1NA 4KBNA 4NX7A 1RX3A 4RGCA 4DPHA 2HXVA 1M78A 4KY8A 2DRCA 1JOLA 1OHJA 5HVEA 2ANQA 5HF0X 4KJJA 5E8QA 2B3ZA 4FHBA 3K47A 5JG0X 2INQA 3D80A 4XT5A 4P66A 4Q0DA 3SH2A 2D0KA 3F0QX 3KFYA 2O7PA 3DRCA 2ITHA 3SRWX 4LAHX 5HQZA 3RG9A 5ECCA 2LF1A 2L28A 3NZ6X 2BLAA 3NZDA 3QG2A 3SRRX 1MVTA 2W3MA 1RF7A 3FRAX 4KFJA 4KD7A 1RX1A 3FL9A 3S7AA 4CD2A 3QLRA 1RA3A 3EX8A 1RX2A 3F0UX 1AOEA 1DYIA 4X5FA 4HA7A 3IA4A 3DL6A 1DR7A 1DR5A 1D1GA 2BLBA 1DYRA 3CD2A 4QLGA 1DLRA 1DG7A 3UM6A 3F0BX 4KEBA 1RH3A 1PDBA 4ELFA 4LEKX 3SA1A 3NRRA 1CD2A 5HQYA 4EILA 4KJKA 1DRFA 4Q0EA 5HPBA 3SA2A 1RX5A 5ECXA 2CIGA 2FZIA 3QYOA 1AO8A 5U26A 4M6LA 2W3AA 2GD9A 3F8YA 4G3MA 4XT8A 4DPDA 4P3QA 5FDAA 1HFPA 3IROA 3QLWA 1ZDRA 5HSRA 3ZPCA 1KMSA 4LAEX 4X5GA 4H98A 5DXVA 3NXOA 2W3WA 3NTZA 3GYFA 4KY4A 4EIZA 3DL5A 4I13A 3SR5X 4PSSA 3KJSA 1S3VA 4Q67A 1LY4A 1RC4A 5EAJA 1DR6A 4QJZD 4PDJA 1E26A 3FQCA 3S9UA 3VCOA 1U72A 2W9SA 4FGGA 4OR7A 1LY3A 3FQOA 3OCHA 1RX8A 3CLBA 4KLXA 1DDSA 3NZAX 2BLCA 2W9GA 4NX6A 2AZNA 2CD2A 7DFRA 3SQYX 3F91A 3GHVA 3SRQX 3EEKA 1RA9A 3GHCA 4KAKA 1DISA 3QFXA 4HOEA 3FS6A 4M7UA 5DFRA 3JTWA 3KGYA 4H95A 3DFRA 3NU0A 4XE6X 2G6VA 1IA2A 3NXXA 8DFRA 1AI9A 1DG5A 4M6JA 1DRAA 3SRSX 4H96A 1DYJA 2C2SA 2W3BA 4TU5X 3FY8X 1MVSA 4ELHA 4QJCA 1DYHA 1U70A 1DRHA 4DFRA 1DLSA 3NXTA 1KLKA 1RB3A 2C2TA 2DHFA 3I3RA 1KMVA 3QL3A 4IXED 3Q1HA 4QLFA 4XT7A 1DDRA 5CC9A 2ANOA 5HVBA 3EEJA 3KY8A 1YHOA 2P4GA 4XT4A 2W9HA 4M6KA 3SGYA 1BZFA 4KJLA 4QHVA 1VJ3A 5JA3A 4IXFX 1SEJA 4M2XA 1HFRA 3TD8A 3FQ0A 1RX9A 2HQPA 3K45A 4KM2A 4ECKA 5HT5A 3ROAA 4X5IA 3NZ9X 3QYLA 4X5JA 1DR1A 2QK8A 3FQZA 3HJ3A 4QLEA 3SAIA 3JW5A 3UM5A 1J3JA 4PSYA 4XRBA 1HFQA 5HUIA 1OHKA 1S3WA 3FRFX 3FQVA 1J3IA 3F0SX 4HOFA 3M08A 1QZFA 3K2HA 2H2QA 3IA5A 4KL9A 3FYWX 3F0VX 3QLYA 3DGAA 1DIUA 4G95A 3S3VA 1M79A 3EEMA 1DAJA 1DR4A 1RE7A 3DG8A 1RX4A 5U27A 3TQAA 1CZ3A 3TQ9A 1DRBA 1U71A 3NXRA 1RA2A 1RG7A 1DG8A 3FREX 1DHJA 2KGKA 4EIGA 3EIGA 3L3RA 4HA9A 3OAFA 1S3UA 2HM9A 3JWKA 5HT4A 5CCCA 3CL9A 6DFRA 1BOZA 2XW7A 3NXYA 4G8ZX 4XECX 3KJRA 3DATA 2OIPA 3FRBX 5HF2X 4ELBA 1DHFA 2W9TA 3QLZA
chains in the Genus database with same CATH superfamily
3NZBX 2ZZAA 3JWMA 1PD8A 3GI2A 1JUVA 3FRDX 1PD9A 3M09A 1DR2A 3FL8A 3HBBA 1DR3A 4KYAA 4GH8A 3F8ZA 4QI9A 4X5HA 1RX6A 4LAGX 4IXGX 3JSUA 3FQFA 1TDRA 1IA4A 1RX7A 3ZPGA 2FZHA 3I8AX 3FY9X 3QLSA 3JVXA 3CSEA 3DAUA 3R33A 3RO9A 4XT6A 4Q6AA 1JOMA 3SRUX 3E0BA 3TQ8A 1LUDA 3IX9A 3NZCX 3N0HA 4M7VA 1M7AA 1IA3A 1RA8A 4PSTA 3UM8A 3IRNA 4KNEA 4H97A 4KM0A 1VDRA 3EELA 1DREA 3QGTA 3TQBA 3IRMA 1J3KA 1DF7A 1S3YA 3JWCA 1RD7A 4EJ1A 5HSUA 4PTHA 2JYBA 3QLXA 5HI6A 1RA1A 3LG4A 3JWFA 2BL9A 4P3RA 4DDRA 3FYVX 3GHWA 3F0XX 1IA1A 3QL0A 4ELGA 4DP3A 3D84X 4HOGA 4P68A 2FZJA 2OBCA 1DHIA 2W3VA 4FGHA 4ELEA 3K74A 2D5NA 3NXVA 1RB2A 4PTJA 4OSGA 3JW3A 3INVA 4I1NA 4KBNA 4NX7A 1RX3A 4RGCA 4DPHA 2HXVA 1M78A 4KY8A 2DRCA 1JOLA 1OHJA 5HVEA 2ANQA 5HF0X 4KJJA 5E8QA 2B3ZA 4FHBA 3K47A 5JG0X 2INQA 3D80A 4XT5A 4P66A 4Q0DA 3SH2A 2D0KA 3F0QX 3KFYA 2O7PA 3DRCA 2ITHA 3SRWX 4LAHX 5HQZA 3RG9A 5ECCA 2LF1A 2L28A 3NZ6X 2BLAA 3NZDA 3QG2A 3SRRX 1MVTA 2W3MA 1RF7A 3FRAX 4KFJA 4KD7A 1RX1A 3FL9A 3S7AA 4CD2A 3QLRA 1RA3A 3EX8A 1RX2A 3F0UX 1AOEA 1DYIA 4X5FA 4HA7A 3IA4A 3DL6A 1DR7A 1DR5A 1D1GA 2BLBA 1DYRA 3CD2A 4QLGA 1DLRA 1DG7A 3UM6A 3F0BX 4KEBA 1RH3A 1PDBA 4ELFA 4LEKX 3SA1A 3NRRA 1CD2A 5HQYA 4EILA 4KJKA 1DRFA 4Q0EA 5HPBA 3SA2A 1RX5A 5ECXA 2CIGA 2FZIA 3QYOA 1AO8A 5U26A 4M6LA 2W3AA 2GD9A 3F8YA 4G3MA 4XT8A 4DPDA 4P3QA 5FDAA 1HFPA 3IROA 3QLWA 1ZDRA 5HSRA 3ZPCA 1KMSA 4LAEX 4X5GA 4H98A 5DXVA 3NXOA 2W3WA 3NTZA 3GYFA 4KY4A 4EIZA 3DL5A 4I13A 3SR5X 4PSSA 3KJSA 1S3VA 4Q67A 1LY4A 1RC4A 5EAJA 1DR6A 4QJZD 4PDJA 1E26A 3FQCA 3S9UA 3VCOA 1U72A 2W9SA 4FGGA 4OR7A 1LY3A 3FQOA 3OCHA 1RX8A 3CLBA 4KLXA 1DDSA 3NZAX 2BLCA 2W9GA 4NX6A 2AZNA 2CD2A 7DFRA 3SQYX 3F91A 3GHVA 3SRQX 3EEKA 1RA9A 3GHCA 4KAKA 1DISA 3QFXA 4HOEA 3FS6A 4M7UA 5DFRA 3JTWA 3KGYA 4H95A 3DFRA 3NU0A 4XE6X 2G6VA 1IA2A 3NXXA 8DFRA 1AI9A 1DG5A 4M6JA 1DRAA 3SRSX 4H96A 1DYJA 2C2SA 2W3BA 4TU5X 3FY8X 1MVSA 4ELHA 4QJCA 1DYHA 1U70A 1DRHA 4DFRA 1DLSA 3NXTA 1KLKA 1RB3A 2C2TA 2DHFA 3I3RA 1KMVA 3QL3A 4IXED 3Q1HA 4QLFA 4XT7A 1DDRA 5CC9A 2ANOA 5HVBA 3EEJA 3KY8A 1YHOA 2P4GA 4XT4A 2W9HA 4M6KA 3SGYA 1BZFA 4KJLA 4QHVA 1VJ3A 5JA3A 4IXFX 1SEJA 4M2XA 1HFRA 3TD8A 3FQ0A 1RX9A 2HQPA 3K45A 4KM2A 4ECKA 5HT5A 3ROAA 4X5IA 3NZ9X 3QYLA 4X5JA 1DR1A 2QK8A 3FQZA 3HJ3A 4QLEA 3SAIA 3JW5A 3UM5A 1J3JA 4PSYA 4XRBA 1HFQA 5HUIA 1OHKA 1S3WA 3FRFX 3FQVA 1J3IA 3F0SX 4HOFA 3M08A 1QZFA 3K2HA 2H2QA 3IA5A 4KL9A 3FYWX 3F0VX 3QLYA 3DGAA 1DIUA 4G95A 3S3VA 1M79A 3EEMA 1DAJA 1DR4A 1RE7A 3DG8A 1RX4A 5U27A 3TQAA 1CZ3A 3TQ9A 1DRBA 1U71A 3NXRA 1RA2A 1RG7A 1DG8A 3FREX 1DHJA 2KGKA 4EIGA 3EIGA 3L3RA 4HA9A 3OAFA 1S3UA 2HM9A 3JWKA 5HT4A 5CCCA 3CL9A 6DFRA 1BOZA 2XW7A 3NXYA 4G8ZX 4XECX 3KJRA 3DATA 2OIPA 3FRBX 5HF2X 4ELBA 1DHFA 2W9TA 3QLZA
chains in the Genus database with same CATH topology
3NZBX 2ZZAA 3JWMA 1PD8A 3GI2A 1JUVA 3FRDX 1PD9A 3M09A 1DR2A 3FL8A 3HBBA 1DR3A 4KYAA 4GH8A 3F8ZA 4QI9A 4X5HA 1RX6A 4LAGX 4IXGX 3JSUA 3FQFA 1TDRA 1IA4A 1RX7A 3ZPGA 2FZHA 3I8AX 3FY9X 3QLSA 3JVXA 3CSEA 3DAUA 3R33A 3RO9A 4XT6A 4Q6AA 1JOMA 3SRUX 3E0BA 3TQ8A 1LUDA 3IX9A 3NZCX 3N0HA 4M7VA 1M7AA 1IA3A 1RA8A 4PSTA 3UM8A 3IRNA 4KNEA 4H97A 4KM0A 1VDRA 3EELA 1DREA 3QGTA 3TQBA 3IRMA 1J3KA 1DF7A 1S3YA 3JWCA 1RD7A 4EJ1A 5HSUA 4PTHA 2JYBA 3QLXA 5HI6A 1RA1A 3LG4A 3JWFA 2BL9A 4P3RA 4DDRA 3FYVX 3GHWA 3F0XX 1IA1A 3QL0A 4ELGA 4DP3A 3D84X 4HOGA 4P68A 2FZJA 2OBCA 1DHIA 2W3VA 4FGHA 4ELEA 3K74A 2D5NA 3NXVA 1RB2A 4PTJA 4OSGA 3JW3A 3INVA 4I1NA 4KBNA 4NX7A 1RX3A 4RGCA 4DPHA 2HXVA 1M78A 4KY8A 2DRCA 1JOLA 1OHJA 5HVEA 2ANQA 5HF0X 4KJJA 5E8QA 2B3ZA 4FHBA 3K47A 5JG0X 2INQA 3D80A 4XT5A 4P66A 4Q0DA 3SH2A 2D0KA 3F0QX 3KFYA 2O7PA 3DRCA 2ITHA 3SRWX 4LAHX 5HQZA 3RG9A 5ECCA 2LF1A 2L28A 3NZ6X 2BLAA 3NZDA 3QG2A 3SRRX 1MVTA 2W3MA 1RF7A 3FRAX 4KFJA 4KD7A 1RX1A 3FL9A 3S7AA 4CD2A 3QLRA 1RA3A 3EX8A 1RX2A 3F0UX 1AOEA 1DYIA 4X5FA 4HA7A 3IA4A 3DL6A 1DR7A 1DR5A 1D1GA 2BLBA 1DYRA 3CD2A 4QLGA 1DLRA 1DG7A 3UM6A 3F0BX 4KEBA 1RH3A 1PDBA 4ELFA 4LEKX 3SA1A 3NRRA 1CD2A 5HQYA 4EILA 4KJKA 1DRFA 4Q0EA 5HPBA 3SA2A 1RX5A 5ECXA 2CIGA 2FZIA 3QYOA 1AO8A 5U26A 4M6LA 2W3AA 2GD9A 3F8YA 4G3MA 4XT8A 4DPDA 4P3QA 5FDAA 1HFPA 3IROA 3QLWA 1ZDRA 5HSRA 3ZPCA 1KMSA 4LAEX 4X5GA 4H98A 5DXVA 3NXOA 2W3WA 3NTZA 3GYFA 4KY4A 4EIZA 3DL5A 4I13A 3SR5X 4PSSA 3KJSA 1S3VA 4Q67A 1LY4A 1RC4A 5EAJA 1DR6A 4QJZD 4PDJA 1E26A 3FQCA 3S9UA 3VCOA 1U72A 2W9SA 4FGGA 4OR7A 1LY3A 3FQOA 3OCHA 1RX8A 3CLBA 4KLXA 1DDSA 3NZAX 2BLCA 2W9GA 4NX6A 2AZNA 2CD2A 7DFRA 3SQYX 3F91A 3GHVA 3SRQX 3EEKA 1RA9A 3GHCA 4KAKA 1DISA 3QFXA 4HOEA 3FS6A 4M7UA 5DFRA 3JTWA 3KGYA 4H95A 3DFRA 3NU0A 4XE6X 2G6VA 1IA2A 3NXXA 8DFRA 1AI9A 1DG5A 4M6JA 1DRAA 3SRSX 4H96A 1DYJA 2C2SA 2W3BA 4TU5X 3FY8X 1MVSA 4ELHA 4QJCA 1DYHA 1U70A 1DRHA 4DFRA 1DLSA 3NXTA 1KLKA 1RB3A 2C2TA 2DHFA 3I3RA 1KMVA 3QL3A 4IXED 3Q1HA 4QLFA 4XT7A 1DDRA 5CC9A 2ANOA 5HVBA 3EEJA 3KY8A 1YHOA 2P4GA 4XT4A 2W9HA 4M6KA 3SGYA 1BZFA 4KJLA 4QHVA 1VJ3A 5JA3A 4IXFX 1SEJA 4M2XA 1HFRA 3TD8A 3FQ0A 1RX9A 2HQPA 3K45A 4KM2A 4ECKA 5HT5A 3ROAA 4X5IA 3NZ9X 3QYLA 4X5JA 1DR1A 2QK8A 3FQZA 3HJ3A 4QLEA 3SAIA 3JW5A 3UM5A 1J3JA 4PSYA 4XRBA 1HFQA 5HUIA 1OHKA 1S3WA 3FRFX 3FQVA 1J3IA 3F0SX 4HOFA 3M08A 1QZFA 3K2HA 2H2QA 3IA5A 4KL9A 3FYWX 3F0VX 3QLYA 3DGAA 1DIUA 4G95A 3S3VA 1M79A 3EEMA 1DAJA 1DR4A 1RE7A 3DG8A 1RX4A 5U27A 3TQAA 1CZ3A 3TQ9A 1DRBA 1U71A 3NXRA 1RA2A 1RG7A 1DG8A 3FREX 1DHJA 2KGKA 4EIGA 3EIGA 3L3RA 4HA9A 3OAFA 1S3UA 2HM9A 3JWKA 5HT4A 5CCCA 3CL9A 6DFRA 1BOZA 2XW7A 3NXYA 4G8ZX 4XECX 3KJRA 3DATA 2OIPA 3FRBX 5HF2X 4ELBA 1DHFA 2W9TA 3QLZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NZB X;  2ZZA A;  3JWM A;  1PD8 A;  3GI2 A;  1JUV A;  3FRD X;  1PD9 A;  3M09 A;  1DR2 A;  3FL8 A;  3HBB A;  1DR3 A;  4KYA A;  4GH8 A;  3F8Z A;  4QI9 A;  4X5H A;  1RX6 A;  4LAG X;  4IXG X;  3JSU A;  3FQF A;  1TDR A;  1IA4 A;  1RX7 A;  3ZPG A;  2FZH A;  3I8A X;  3FY9 X;  3QLS A;  3JVX A;  3CSE A;  3DAU A;  3R33 A;  3RO9 A;  4XT6 A;  4Q6A A;  1JOM A;  3SRU X;  3E0B A;  3TQ8 A;  1LUD A;  3IX9 A;  3NZC X;  3N0H A;  4M7V A;  1M7A A;  1IA3 A;  1RA8 A;  4PST A;  3UM8 A;  3IRN A;  4KNE A;  4H97 A;  4KM0 A;  1VDR A;  3EEL A;  1DRE A;  3QGT A;  3TQB A;  3IRM A;  1J3K A;  1DF7 A;  1S3Y A;  3JWC A;  1RD7 A;  4EJ1 A;  5HSU A;  4PTH A;  2JYB A;  3QLX A;  5HI6 A;  1RA1 A;  3LG4 A;  3JWF A;  2BL9 A;  4P3R A;  4DDR A;  3FYV X;  3GHW A;  3F0X X;  1IA1 A;  3QL0 A;  4ELG A;  4DP3 A;  3D84 X;  4HOG A;  4P68 A;  2FZJ A;  2OBC A;  1DHI A;  2W3V A;  4FGH A;  4ELE A;  3K74 A;  2D5N A;  3NXV A;  1RB2 A;  4PTJ A;  4OSG A;  3JW3 A;  3INV A;  4I1N A;  4KBN A;  4NX7 A;  1RX3 A;  4RGC A;  4DPH A;  2HXV A;  1M78 A;  4KY8 A;  2DRC A;  1JOL A;  1OHJ A;  5HVE A;  2ANQ A;  5HF0 X;  4KJJ A;  5E8Q A;  2B3Z A;  4FHB A;  3K47 A;  5JG0 X;  2INQ A;  3D80 A;  4XT5 A;  4P66 A;  4Q0D A;  3SH2 A;  2D0K A;  3F0Q X;  3KFY A;  2O7P A;  3DRC A;  2ITH A;  3SRW X;  4LAH X;  5HQZ A;  3RG9 A;  5ECC A;  2LF1 A;  2L28 A;  3NZ6 X;  2BLA A;  3NZD A;  3QG2 A;  3SRR X;  1MVT A;  2W3M A;  1RF7 A;  3FRA X;  4KFJ A;  4KD7 A;  1RX1 A;  3FL9 A;  3S7A A;  4CD2 A;  3QLR A;  1RA3 A;  3EX8 A;  1RX2 A;  3F0U X;  1AOE A;  1DYI A;  4X5F A;  4HA7 A;  3IA4 A;  3DL6 A;  1DR7 A;  1DR5 A;  1D1G A;  2BLB A;  1DYR A;  3CD2 A;  4QLG A;  1DLR A;  1DG7 A;  3UM6 A;  3F0B X;  4KEB A;  1RH3 A;  1PDB A;  4ELF A;  4LEK X;  3SA1 A;  3NRR A;  1CD2 A;  5HQY A;  4EIL A;  4KJK A;  1DRF A;  4Q0E A;  5HPB A;  3SA2 A;  1RX5 A;  5ECX A;  2CIG A;  2FZI A;  3QYO A;  1AO8 A;  5U26 A;  4M6L A;  2W3A A;  2GD9 A;  3F8Y A;  4G3M A;  4XT8 A;  4DPD A;  4P3Q A;  5FDA A;  1HFP A;  3IRO A;  3QLW A;  1ZDR A;  5HSR A;  3ZPC A;  1KMS A;  4LAE X;  4X5G A;  4H98 A;  5DXV A;  3NXO A;  2W3W A;  3NTZ A;  3GYF A;  4KY4 A;  4EIZ A;  3DL5 A;  4I13 A;  3SR5 X;  4PSS A;  3KJS A;  1S3V A;  4Q67 A;  1LY4 A;  1RC4 A;  5EAJ A;  1DR6 A;  4QJZ D;  4PDJ A;  1E26 A;  3FQC A;  3S9U A;  3VCO A;  1U72 A;  2W9S A;  4FGG A;  4OR7 A;  1LY3 A;  3FQO A;  3OCH A;  1RX8 A;  3CLB A;  4KLX A;  1DDS A;  3NZA X;  2BLC A;  2W9G A;  4NX6 A;  2AZN A;  2CD2 A;  7DFR A;  3SQY X;  3F91 A;  3GHV A;  3SRQ X;  3EEK A;  1RA9 A;  3GHC A;  4KAK A;  1DIS A;  3QFX A;  4HOE A;  3FS6 A;  4M7U A;  5DFR A;  3JTW A;  3KGY A;  4H95 A;  3DFR A;  3NU0 A;  4XE6 X;  2G6V A;  1IA2 A;  3NXX A;  8DFR A;  1AI9 A;  1DG5 A;  4M6J A;  1DRA A;  3SRS X;  4H96 A;  1DYJ A;  2C2S A;  2W3B A;  4TU5 X;  3FY8 X;  1MVS A;  4ELH A;  4QJC A;  1DYH A;  1U70 A;  1DRH A;  4DFR A;  1DLS A;  3NXT A;  1KLK A;  1RB3 A;  2C2T A;  2DHF A;  3I3R A;  1KMV A;  3QL3 A;  4IXE D;  3Q1H A;  4QLF A;  4XT7 A;  1DDR A;  5CC9 A;  2ANO A;  5HVB A;  3EEJ A;  3KY8 A;  1YHO A;  2P4G A;  4XT4 A;  2W9H A;  4M6K A;  3SGY A;  1BZF A;  4KJL A;  4QHV A;  1VJ3 A;  5JA3 A;  4IXF X;  1SEJ A;  4M2X A;  1HFR A;  3TD8 A;  3FQ0 A;  1RX9 A;  2HQP A;  3K45 A;  4KM2 A;  4ECK A;  5HT5 A;  3ROA A;  4X5I A;  3NZ9 X;  3QYL A;  4X5J A;  1DR1 A;  2QK8 A;  3FQZ A;  3HJ3 A;  4QLE A;  3SAI A;  3JW5 A;  3UM5 A;  1J3J A;  4PSY A;  4XRB A;  1HFQ A;  5HUI A;  1OHK A;  1S3W A;  3FRF X;  3FQV A;  1J3I A;  3F0S X;  4HOF A;  3M08 A;  1QZF A;  3K2H A;  2H2Q A;  3IA5 A;  4KL9 A;  3FYW X;  3F0V X;  3QLY A;  3DGA A;  1DIU A;  4G95 A;  3S3V A;  1M79 A;  3EEM A;  1DAJ A;  1DR4 A;  1RE7 A;  3DG8 A;  1RX4 A;  5U27 A;  3TQA A;  1CZ3 A;  3TQ9 A;  1DRB A;  1U71 A;  3NXR A;  1RA2 A;  1RG7 A;  1DG8 A;  3FRE X;  1DHJ A;  2KGK A;  4EIG A;  3EIG A;  3L3R A;  4HA9 A;  3OAF A;  1S3U A;  2HM9 A;  3JWK A;  5HT4 A;  5CCC A;  3CL9 A;  6DFR A;  1BOZ A;  2XW7 A;  3NXY A;  4G8Z X;  4XEC X;  3KJR A;  3DAT A;  2OIP A;  3FRB X;  5HF2 X;  4ELB A;  1DHF A;  2W9T A;  3QLZ A; 
#chains in the Genus database with same CATH topology
 3NZB X;  2ZZA A;  3JWM A;  1PD8 A;  3GI2 A;  1JUV A;  3FRD X;  1PD9 A;  3M09 A;  1DR2 A;  3FL8 A;  3HBB A;  1DR3 A;  4KYA A;  4GH8 A;  3F8Z A;  4QI9 A;  4X5H A;  1RX6 A;  4LAG X;  4IXG X;  3JSU A;  3FQF A;  1TDR A;  1IA4 A;  1RX7 A;  3ZPG A;  2FZH A;  3I8A X;  3FY9 X;  3QLS A;  3JVX A;  3CSE A;  3DAU A;  3R33 A;  3RO9 A;  4XT6 A;  4Q6A A;  1JOM A;  3SRU X;  3E0B A;  3TQ8 A;  1LUD A;  3IX9 A;  3NZC X;  3N0H A;  4M7V A;  1M7A A;  1IA3 A;  1RA8 A;  4PST A;  3UM8 A;  3IRN A;  4KNE A;  4H97 A;  4KM0 A;  1VDR A;  3EEL A;  1DRE A;  3QGT A;  3TQB A;  3IRM A;  1J3K A;  1DF7 A;  1S3Y A;  3JWC A;  1RD7 A;  4EJ1 A;  5HSU A;  4PTH A;  2JYB A;  3QLX A;  5HI6 A;  1RA1 A;  3LG4 A;  3JWF A;  2BL9 A;  4P3R A;  4DDR A;  3FYV X;  3GHW A;  3F0X X;  1IA1 A;  3QL0 A;  4ELG A;  4DP3 A;  3D84 X;  4HOG A;  4P68 A;  2FZJ A;  2OBC A;  1DHI A;  2W3V A;  4FGH A;  4ELE A;  3K74 A;  2D5N A;  3NXV A;  1RB2 A;  4PTJ A;  4OSG A;  3JW3 A;  3INV A;  4I1N A;  4KBN A;  4NX7 A;  1RX3 A;  4RGC A;  4DPH A;  2HXV A;  1M78 A;  4KY8 A;  2DRC A;  1JOL A;  1OHJ A;  5HVE A;  2ANQ A;  5HF0 X;  4KJJ A;  5E8Q A;  2B3Z A;  4FHB A;  3K47 A;  5JG0 X;  2INQ A;  3D80 A;  4XT5 A;  4P66 A;  4Q0D A;  3SH2 A;  2D0K A;  3F0Q X;  3KFY A;  2O7P A;  3DRC A;  2ITH A;  3SRW X;  4LAH X;  5HQZ A;  3RG9 A;  5ECC A;  2LF1 A;  2L28 A;  3NZ6 X;  2BLA A;  3NZD A;  3QG2 A;  3SRR X;  1MVT A;  2W3M A;  1RF7 A;  3FRA X;  4KFJ A;  4KD7 A;  1RX1 A;  3FL9 A;  3S7A A;  4CD2 A;  3QLR A;  1RA3 A;  3EX8 A;  1RX2 A;  3F0U X;  1AOE A;  1DYI A;  4X5F A;  4HA7 A;  3IA4 A;  3DL6 A;  1DR7 A;  1DR5 A;  1D1G A;  2BLB A;  1DYR A;  3CD2 A;  4QLG A;  1DLR A;  1DG7 A;  3UM6 A;  3F0B X;  4KEB A;  1RH3 A;  1PDB A;  4ELF A;  4LEK X;  3SA1 A;  3NRR A;  1CD2 A;  5HQY A;  4EIL A;  4KJK A;  1DRF A;  4Q0E A;  5HPB A;  3SA2 A;  1RX5 A;  5ECX A;  2CIG A;  2FZI A;  3QYO A;  1AO8 A;  5U26 A;  4M6L A;  2W3A A;  2GD9 A;  3F8Y A;  4G3M A;  4XT8 A;  4DPD A;  4P3Q A;  5FDA A;  1HFP A;  3IRO A;  3QLW A;  1ZDR A;  5HSR A;  3ZPC A;  1KMS A;  4LAE X;  4X5G A;  4H98 A;  5DXV A;  3NXO A;  2W3W A;  3NTZ A;  3GYF A;  4KY4 A;  4EIZ A;  3DL5 A;  4I13 A;  3SR5 X;  4PSS A;  3KJS A;  1S3V A;  4Q67 A;  1LY4 A;  1RC4 A;  5EAJ A;  1DR6 A;  4QJZ D;  4PDJ A;  1E26 A;  3FQC A;  3S9U A;  3VCO A;  1U72 A;  2W9S A;  4FGG A;  4OR7 A;  1LY3 A;  3FQO A;  3OCH A;  1RX8 A;  3CLB A;  4KLX A;  1DDS A;  3NZA X;  2BLC A;  2W9G A;  4NX6 A;  2AZN A;  2CD2 A;  7DFR A;  3SQY X;  3F91 A;  3GHV A;  3SRQ X;  3EEK A;  1RA9 A;  3GHC A;  4KAK A;  1DIS A;  3QFX A;  4HOE A;  3FS6 A;  4M7U A;  5DFR A;  3JTW A;  3KGY A;  4H95 A;  3DFR A;  3NU0 A;  4XE6 X;  2G6V A;  1IA2 A;  3NXX A;  8DFR A;  1AI9 A;  1DG5 A;  4M6J A;  1DRA A;  3SRS X;  4H96 A;  1DYJ A;  2C2S A;  2W3B A;  4TU5 X;  3FY8 X;  1MVS A;  4ELH A;  4QJC A;  1DYH A;  1U70 A;  1DRH A;  4DFR A;  1DLS A;  3NXT A;  1KLK A;  1RB3 A;  2C2T A;  2DHF A;  3I3R A;  1KMV A;  3QL3 A;  4IXE D;  3Q1H A;  4QLF A;  4XT7 A;  1DDR A;  5CC9 A;  2ANO A;  5HVB A;  3EEJ A;  3KY8 A;  1YHO A;  2P4G A;  4XT4 A;  2W9H A;  4M6K A;  3SGY A;  1BZF A;  4KJL A;  4QHV A;  1VJ3 A;  5JA3 A;  4IXF X;  1SEJ A;  4M2X A;  1HFR A;  3TD8 A;  3FQ0 A;  1RX9 A;  2HQP A;  3K45 A;  4KM2 A;  4ECK A;  5HT5 A;  3ROA A;  4X5I A;  3NZ9 X;  3QYL A;  4X5J A;  1DR1 A;  2QK8 A;  3FQZ A;  3HJ3 A;  4QLE A;  3SAI A;  3JW5 A;  3UM5 A;  1J3J A;  4PSY A;  4XRB A;  1HFQ A;  5HUI A;  1OHK A;  1S3W A;  3FRF X;  3FQV A;  1J3I A;  3F0S X;  4HOF A;  3M08 A;  1QZF A;  3K2H A;  2H2Q A;  3IA5 A;  4KL9 A;  3FYW X;  3F0V X;  3QLY A;  3DGA A;  1DIU A;  4G95 A;  3S3V A;  1M79 A;  3EEM A;  1DAJ A;  1DR4 A;  1RE7 A;  3DG8 A;  1RX4 A;  5U27 A;  3TQA A;  1CZ3 A;  3TQ9 A;  1DRB A;  1U71 A;  3NXR A;  1RA2 A;  1RG7 A;  1DG8 A;  3FRE X;  1DHJ A;  2KGK A;  4EIG A;  3EIG A;  3L3R A;  4HA9 A;  3OAF A;  1S3U A;  2HM9 A;  3JWK A;  5HT4 A;  5CCC A;  3CL9 A;  6DFR A;  1BOZ A;  2XW7 A;  3NXY A;  4G8Z X;  4XEC X;  3KJR A;  3DAT A;  2OIP A;  3FRB X;  5HF2 X;  4ELB A;  1DHF A;  2W9T A;  3QLZ A; 
#chains in the Genus database with same CATH homology
 3NZB X;  2ZZA A;  3JWM A;  1PD8 A;  3GI2 A;  1JUV A;  3FRD X;  1PD9 A;  3M09 A;  1DR2 A;  3FL8 A;  3HBB A;  1DR3 A;  4KYA A;  4GH8 A;  3F8Z A;  4QI9 A;  4X5H A;  1RX6 A;  4LAG X;  4IXG X;  3JSU A;  3FQF A;  1TDR A;  1IA4 A;  1RX7 A;  3ZPG A;  2FZH A;  3I8A X;  3FY9 X;  3QLS A;  3JVX A;  3CSE A;  3DAU A;  3R33 A;  3RO9 A;  4XT6 A;  4Q6A A;  1JOM A;  3SRU X;  3E0B A;  3TQ8 A;  1LUD A;  3IX9 A;  3NZC X;  3N0H A;  4M7V A;  1M7A A;  1IA3 A;  1RA8 A;  4PST A;  3UM8 A;  3IRN A;  4KNE A;  4H97 A;  4KM0 A;  1VDR A;  3EEL A;  1DRE A;  3QGT A;  3TQB A;  3IRM A;  1J3K A;  1DF7 A;  1S3Y A;  3JWC A;  1RD7 A;  4EJ1 A;  5HSU A;  4PTH A;  2JYB A;  3QLX A;  5HI6 A;  1RA1 A;  3LG4 A;  3JWF A;  2BL9 A;  4P3R A;  4DDR A;  3FYV X;  3GHW A;  3F0X X;  1IA1 A;  3QL0 A;  4ELG A;  4DP3 A;  3D84 X;  4HOG A;  4P68 A;  2FZJ A;  2OBC A;  1DHI A;  2W3V A;  4FGH A;  4ELE A;  3K74 A;  2D5N A;  3NXV A;  1RB2 A;  4PTJ A;  4OSG A;  3JW3 A;  3INV A;  4I1N A;  4KBN A;  4NX7 A;  1RX3 A;  4RGC A;  4DPH A;  2HXV A;  1M78 A;  4KY8 A;  2DRC A;  1JOL A;  1OHJ A;  5HVE A;  2ANQ A;  5HF0 X;  4KJJ A;  5E8Q A;  2B3Z A;  4FHB A;  3K47 A;  5JG0 X;  2INQ A;  3D80 A;  4XT5 A;  4P66 A;  4Q0D A;  3SH2 A;  2D0K A;  3F0Q X;  3KFY A;  2O7P A;  3DRC A;  2ITH A;  3SRW X;  4LAH X;  5HQZ A;  3RG9 A;  5ECC A;  2LF1 A;  2L28 A;  3NZ6 X;  2BLA A;  3NZD A;  3QG2 A;  3SRR X;  1MVT A;  2W3M A;  1RF7 A;  3FRA X;  4KFJ A;  4KD7 A;  1RX1 A;  3FL9 A;  3S7A A;  4CD2 A;  3QLR A;  1RA3 A;  3EX8 A;  1RX2 A;  3F0U X;  1AOE A;  1DYI A;  4X5F A;  4HA7 A;  3IA4 A;  3DL6 A;  1DR7 A;  1DR5 A;  1D1G A;  2BLB A;  1DYR A;  3CD2 A;  4QLG A;  1DLR A;  1DG7 A;  3UM6 A;  3F0B X;  4KEB A;  1RH3 A;  1PDB A;  4ELF A;  4LEK X;  3SA1 A;  3NRR A;  1CD2 A;  5HQY A;  4EIL A;  4KJK A;  1DRF A;  4Q0E A;  5HPB A;  3SA2 A;  1RX5 A;  5ECX A;  2CIG A;  2FZI A;  3QYO A;  1AO8 A;  5U26 A;  4M6L A;  2W3A A;  2GD9 A;  3F8Y A;  4G3M A;  4XT8 A;  4DPD A;  4P3Q A;  5FDA A;  1HFP A;  3IRO A;  3QLW A;  1ZDR A;  5HSR A;  3ZPC A;  1KMS A;  4LAE X;  4X5G A;  4H98 A;  5DXV A;  3NXO A;  2W3W A;  3NTZ A;  3GYF A;  4KY4 A;  4EIZ A;  3DL5 A;  4I13 A;  3SR5 X;  4PSS A;  3KJS A;  1S3V A;  4Q67 A;  1LY4 A;  1RC4 A;  5EAJ A;  1DR6 A;  4QJZ D;  4PDJ A;  1E26 A;  3FQC A;  3S9U A;  3VCO A;  1U72 A;  2W9S A;  4FGG A;  4OR7 A;  1LY3 A;  3FQO A;  3OCH A;  1RX8 A;  3CLB A;  4KLX A;  1DDS A;  3NZA X;  2BLC A;  2W9G A;  4NX6 A;  2AZN A;  2CD2 A;  7DFR A;  3SQY X;  3F91 A;  3GHV A;  3SRQ X;  3EEK A;  1RA9 A;  3GHC A;  4KAK A;  1DIS A;  3QFX A;  4HOE A;  3FS6 A;  4M7U A;  5DFR A;  3JTW A;  3KGY A;  4H95 A;  3DFR A;  3NU0 A;  4XE6 X;  2G6V A;  1IA2 A;  3NXX A;  8DFR A;  1AI9 A;  1DG5 A;  4M6J A;  1DRA A;  3SRS X;  4H96 A;  1DYJ A;  2C2S A;  2W3B A;  4TU5 X;  3FY8 X;  1MVS A;  4ELH A;  4QJC A;  1DYH A;  1U70 A;  1DRH A;  4DFR A;  1DLS A;  3NXT A;  1KLK A;  1RB3 A;  2C2T A;  2DHF A;  3I3R A;  1KMV A;  3QL3 A;  4IXE D;  3Q1H A;  4QLF A;  4XT7 A;  1DDR A;  5CC9 A;  2ANO A;  5HVB A;  3EEJ A;  3KY8 A;  1YHO A;  2P4G A;  4XT4 A;  2W9H A;  4M6K A;  3SGY A;  1BZF A;  4KJL A;  4QHV A;  1VJ3 A;  5JA3 A;  4IXF X;  1SEJ A;  4M2X A;  1HFR A;  3TD8 A;  3FQ0 A;  1RX9 A;  2HQP A;  3K45 A;  4KM2 A;  4ECK A;  5HT5 A;  3ROA A;  4X5I A;  3NZ9 X;  3QYL A;  4X5J A;  1DR1 A;  2QK8 A;  3FQZ A;  3HJ3 A;  4QLE A;  3SAI A;  3JW5 A;  3UM5 A;  1J3J A;  4PSY A;  4XRB A;  1HFQ A;  5HUI A;  1OHK A;  1S3W A;  3FRF X;  3FQV A;  1J3I A;  3F0S X;  4HOF A;  3M08 A;  1QZF A;  3K2H A;  2H2Q A;  3IA5 A;  4KL9 A;  3FYW X;  3F0V X;  3QLY A;  3DGA A;  1DIU A;  4G95 A;  3S3V A;  1M79 A;  3EEM A;  1DAJ A;  1DR4 A;  1RE7 A;  3DG8 A;  1RX4 A;  5U27 A;  3TQA A;  1CZ3 A;  3TQ9 A;  1DRB A;  1U71 A;  3NXR A;  1RA2 A;  1RG7 A;  1DG8 A;  3FRE X;  1DHJ A;  2KGK A;  4EIG A;  3EIG A;  3L3R A;  4HA9 A;  3OAF A;  1S3U A;  2HM9 A;  3JWK A;  5HT4 A;  5CCC A;  3CL9 A;  6DFR A;  1BOZ A;  2XW7 A;  3NXY A;  4G8Z X;  4XEC X;  3KJR A;  3DAT A;  2OIP A;  3FRB X;  5HF2 X;  4ELB A;  1DHF A;  2W9T A;  3QLZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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