4KM0A

Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in complex with pyrimethamine
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
161
structure length
161
Chain Sequence
SHMVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Mycobacterium tuberculosis
molecule keywords Dihydrofolate reductase
total genus 46
structure length 161
sequence length 161
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4km0A00
1RH3A 3F8YA 4KY4A 1U72A 1DRFA 5U27A 2GD9A 1DDRA 3QLXA 2W3MA 4M6KA 4DPHA 4EILA 3IROA 2XW7A 4KAKA 1M7AA 2AZNA 2KGKA 2P4GA 1DLRA 3S7AA 4NX6A 1LUDA 4M6LA 1RX4A 3GI2A 2W9GA 4KFJA 3FQ0A 3NXTA 1IA2A 5HUIA 3LG4A 5HT4A 4M2XA 3TQBA 3IX9A 2HQPA 3I3RA 4GH8A 4KLXA 4P68A 4KY8A 1DRHA 1DR5A 4H95A 3KJRA 3K74A 3QLWA 4ELGA 4PSYA 3JW3A 3SR5X 4KL9A 3M08A 1DYJA 3RG9A 2W9SA 4P66A 2FZHA 1DR3A 5ECXA 3NTZA 1HFPA 3NU0A 1KMSA 3SRSX 1DF7A 3QYOA 3DFRA 4TU5X 4X5GA 4DDRA 3SGYA 5HI6A 3EEJA 4HOFA 3NZ9X 1PDBA 3QLYA 3FY8X 2INQA 1RX5A 4Q6AA 3EX8A 4XRBA 5E8QA 4KD7A 1U71A 4NX7A 2C2SA 3IRMA 3FRBX 4QHVA 4QI9A 1RA8A 1DR4A 3D80A 1VJ3A 3EELA 3NRRA 1OHJA 4CD2A 1DDSA 4HA9A 3NZCX 1DREA 1DG8A 4QLEA 3JWFA 3EEMA 1RX8A 5HSUA 5HVEA 1M79A 1RD7A 1RA9A 4PTHA 4X5JA 1RX1A 3ZPCA 1S3VA 1DIUA 3GHVA 3QL0A 2D5NA 1PD8A 1BZFA 3F0SX 4KJJA 1AO8A 4OR7A 2W3WA 4KEBA 4QJZD 3FQVA 5CC9A 1J3JA 3K2HA 3FYWX 3QG2A 3M09A 4HOEA 4X5FA 1DHIA 1MVSA 4LAGX 1DISA 3NXOA 4DPDA 4DP3A 5HF2X 3GHCA 1JUVA 3F0XX 2CD2A 1KLKA 4PSTA 3KFYA 2HXVA 4X5IA 2ANQA 5ECCA 5HVBA 3NXYA 3N0HA 3KGYA 3FREX 5FDAA 1OHKA 3OAFA 2BL9A 3FQCA 4ECKA 2CIGA 1RA2A 4ELHA 3SA2A 3JVXA 2ITHA 3F91A 1IA4A 4KM2A 3QFXA 3DATA 3QL3A 3R33A 4PDJA 1RX9A 4ELFA 3D84X 8DFRA 4OSGA 1S3WA 3IRNA 1DR6A 3QLZA 1RX3A 4I13A 1DAJA 1ZDRA 3K47A 3NXVA 2ANOA 1IA3A 2BLBA 2C2TA 4Q0DA 4XT7A 3SRQX 3SRWX 5HPBA 2FZJA 2FZIA 1RE7A 1JOLA 4P3RA 3JWCA 3QLRA 1RF7A 3IA5A 3FL9A 1U70A 3FRDX 4FGHA 4EIZA 4XT4A 4KJLA 3I8AX 2G6VA 6DFRA 1RX7A 3EEKA 3JWMA 3ZPGA 2LF1A 3OCHA 1DYHA 3KY8A 2OBCA 4XECX 5HSRA 1RA3A 4I1NA 3TQ9A 5HF0X 3GYFA 1J3IA 2DRCA 4DFRA 1PD9A 3INVA 4XT5A 1D1GA 4XE6X 4XT6A 1HFQA 3E0BA 5HT5A 1DR2A 3JSUA 1YHOA 1QZFA 2D0KA 4KM0A 3TQAA 2H2QA 1DHJA 1AI9A 1DLSA 1JOMA 3CL9A 4M7VA 4EIGA 1KMVA 5JG0X 1DG5A 1CZ3A 3DG8A 4LEKX 3NZDA 4M6JA 2BLCA 3SH2A 4LAHX 3NZ6X 4XT8A 2W9TA 2W9HA 4EJ1A 3FY9X 1DYRA 3IA4A 3SAIA 4HA7A 1J3KA 4G3MA 4H97A 3FS6A 1TDRA 3S9UA 3UM8A 3F0BX 4H98A 1DR1A 3CLBA 3FL8A 3NXRA 1CD2A 7DFRA 3F0QX 3FQOA 1RX2A 5DFRA 3UM6A 2QK8A 1SEJA 2JYBA 3DGAA 4P3QA 1LY3A 3SQYX 3JW5A 5DXVA 2HM9A 2W3BA 4M7UA 1RB3A 3EIGA 4KYAA 4Q0EA 4HOGA 3FQZA 5JA3A 3KJSA 1S3UA 3FQFA 3NZAX 3DRCA 3SA1A 4ELEA 1DRBA 4QJCA 1DRAA 3VCOA 4IXED 1LY4A 2O7PA 3TD8A 5HQYA 3CSEA 1RA1A 3K45A 3HJ3A 3Q1HA 2OIPA 5HQZA 3L3RA 5EAJA 3ROAA 3JWKA 1RX6A 3TQ8A 4FHBA 3F0VX 3JTWA 3FYVX 3F8ZA 3FRFX 1HFRA 2DHFA 3GHWA 4H96A 4X5HA 3DL5A 3SRRX 1AOEA 4FGGA 1RC4A 4RGCA 1VDRA 5U26A 4PTJA 1DHFA 3F0UX 1IA1A 1E26A 3S3VA 4QLFA 3UM5A 4QLGA 3RO9A 2BLAA 3FRAX 1DG7A 4PSSA 1DR7A 4KBNA 4IXGX 2W3VA 4KJKA 3DAUA 3CD2A 3NXXA 4KNEA 4G95A 3SRUX 1RG7A 5CCCA 4LAEX 3DL6A 2L28A 4IXFX 2B3ZA 1S3YA 4G8ZX 2ZZAA 4ELBA 1RB2A 1BOZA 1M78A 1MVTA 4Q67A 1DYIA 3QGTA 2W3AA 3HBBA 3QYLA 3NZBX 3QLSA
chains in the Genus database with same CATH superfamily
1RH3A 3F8YA 4KY4A 1U72A 1DRFA 5U27A 2GD9A 1DDRA 3QLXA 2W3MA 4M6KA 4DPHA 4EILA 3IROA 2XW7A 4KAKA 1M7AA 2AZNA 2KGKA 2P4GA 1DLRA 3S7AA 4NX6A 1LUDA 4M6LA 1RX4A 3GI2A 2W9GA 4KFJA 3FQ0A 3NXTA 1IA2A 5HUIA 3LG4A 5HT4A 4M2XA 3TQBA 3IX9A 2HQPA 3I3RA 4GH8A 4KLXA 4P68A 4KY8A 1DRHA 1DR5A 4H95A 3KJRA 3K74A 3QLWA 4ELGA 4PSYA 3JW3A 3SR5X 4KL9A 3M08A 1DYJA 3RG9A 2W9SA 4P66A 2FZHA 1DR3A 5ECXA 3NTZA 1HFPA 3NU0A 1KMSA 3SRSX 1DF7A 3QYOA 3DFRA 4TU5X 4X5GA 4DDRA 3SGYA 5HI6A 3EEJA 4HOFA 3NZ9X 1PDBA 3QLYA 3FY8X 2INQA 1RX5A 4Q6AA 3EX8A 4XRBA 5E8QA 4KD7A 1U71A 4NX7A 2C2SA 3IRMA 3FRBX 4QHVA 4QI9A 1RA8A 1DR4A 3D80A 1VJ3A 3EELA 3NRRA 1OHJA 4CD2A 1DDSA 4HA9A 3NZCX 1DREA 1DG8A 4QLEA 3JWFA 3EEMA 1RX8A 5HSUA 5HVEA 1M79A 1RD7A 1RA9A 4PTHA 4X5JA 1RX1A 3ZPCA 1S3VA 1DIUA 3GHVA 3QL0A 2D5NA 1PD8A 1BZFA 3F0SX 4KJJA 1AO8A 4OR7A 2W3WA 4KEBA 4QJZD 3FQVA 5CC9A 1J3JA 3K2HA 3FYWX 3QG2A 3M09A 4HOEA 4X5FA 1DHIA 1MVSA 4LAGX 1DISA 3NXOA 4DPDA 4DP3A 5HF2X 3GHCA 1JUVA 3F0XX 2CD2A 1KLKA 4PSTA 3KFYA 2HXVA 4X5IA 2ANQA 5ECCA 5HVBA 3NXYA 3N0HA 3KGYA 3FREX 5FDAA 1OHKA 3OAFA 2BL9A 3FQCA 4ECKA 2CIGA 1RA2A 4ELHA 3SA2A 3JVXA 2ITHA 3F91A 1IA4A 4KM2A 3QFXA 3DATA 3QL3A 3R33A 4PDJA 1RX9A 4ELFA 3D84X 8DFRA 4OSGA 1S3WA 3IRNA 1DR6A 3QLZA 1RX3A 4I13A 1DAJA 1ZDRA 3K47A 3NXVA 2ANOA 1IA3A 2BLBA 2C2TA 4Q0DA 4XT7A 3SRQX 3SRWX 5HPBA 2FZJA 2FZIA 1RE7A 1JOLA 4P3RA 3JWCA 3QLRA 1RF7A 3IA5A 3FL9A 1U70A 3FRDX 4FGHA 4EIZA 4XT4A 4KJLA 3I8AX 2G6VA 6DFRA 1RX7A 3EEKA 3JWMA 3ZPGA 2LF1A 3OCHA 1DYHA 3KY8A 2OBCA 4XECX 5HSRA 1RA3A 4I1NA 3TQ9A 5HF0X 3GYFA 1J3IA 2DRCA 4DFRA 1PD9A 3INVA 4XT5A 1D1GA 4XE6X 4XT6A 1HFQA 3E0BA 5HT5A 1DR2A 3JSUA 1YHOA 1QZFA 2D0KA 4KM0A 3TQAA 2H2QA 1DHJA 1AI9A 1DLSA 1JOMA 3CL9A 4M7VA 4EIGA 1KMVA 5JG0X 1DG5A 1CZ3A 3DG8A 4LEKX 3NZDA 4M6JA 2BLCA 3SH2A 4LAHX 3NZ6X 4XT8A 2W9TA 2W9HA 4EJ1A 3FY9X 1DYRA 3IA4A 3SAIA 4HA7A 1J3KA 4G3MA 4H97A 3FS6A 1TDRA 3S9UA 3UM8A 3F0BX 4H98A 1DR1A 3CLBA 3FL8A 3NXRA 1CD2A 7DFRA 3F0QX 3FQOA 1RX2A 5DFRA 3UM6A 2QK8A 1SEJA 2JYBA 3DGAA 4P3QA 1LY3A 3SQYX 3JW5A 5DXVA 2HM9A 2W3BA 4M7UA 1RB3A 3EIGA 4KYAA 4Q0EA 4HOGA 3FQZA 5JA3A 3KJSA 1S3UA 3FQFA 3NZAX 3DRCA 3SA1A 4ELEA 1DRBA 4QJCA 1DRAA 3VCOA 4IXED 1LY4A 2O7PA 3TD8A 5HQYA 3CSEA 1RA1A 3K45A 3HJ3A 3Q1HA 2OIPA 5HQZA 3L3RA 5EAJA 3ROAA 3JWKA 1RX6A 3TQ8A 4FHBA 3F0VX 3JTWA 3FYVX 3F8ZA 3FRFX 1HFRA 2DHFA 3GHWA 4H96A 4X5HA 3DL5A 3SRRX 1AOEA 4FGGA 1RC4A 4RGCA 1VDRA 5U26A 4PTJA 1DHFA 3F0UX 1IA1A 1E26A 3S3VA 4QLFA 3UM5A 4QLGA 3RO9A 2BLAA 3FRAX 1DG7A 4PSSA 1DR7A 4KBNA 4IXGX 2W3VA 4KJKA 3DAUA 3CD2A 3NXXA 4KNEA 4G95A 3SRUX 1RG7A 5CCCA 4LAEX 3DL6A 2L28A 4IXFX 2B3ZA 1S3YA 4G8ZX 2ZZAA 4ELBA 1RB2A 1BOZA 1M78A 1MVTA 4Q67A 1DYIA 3QGTA 2W3AA 3HBBA 3QYLA 3NZBX 3QLSA
chains in the Genus database with same CATH topology
1RH3A 3F8YA 4KY4A 1U72A 1DRFA 5U27A 2GD9A 1DDRA 3QLXA 2W3MA 4M6KA 4DPHA 4EILA 3IROA 2XW7A 4KAKA 1M7AA 2AZNA 2KGKA 2P4GA 1DLRA 3S7AA 4NX6A 1LUDA 4M6LA 1RX4A 3GI2A 2W9GA 4KFJA 3FQ0A 3NXTA 1IA2A 5HUIA 3LG4A 5HT4A 4M2XA 3TQBA 3IX9A 2HQPA 3I3RA 4GH8A 4KLXA 4P68A 4KY8A 1DRHA 1DR5A 4H95A 3KJRA 3K74A 3QLWA 4ELGA 4PSYA 3JW3A 3SR5X 4KL9A 3M08A 1DYJA 3RG9A 2W9SA 4P66A 2FZHA 1DR3A 5ECXA 3NTZA 1HFPA 3NU0A 1KMSA 3SRSX 1DF7A 3QYOA 3DFRA 4TU5X 4X5GA 4DDRA 3SGYA 5HI6A 3EEJA 4HOFA 3NZ9X 1PDBA 3QLYA 3FY8X 2INQA 1RX5A 4Q6AA 3EX8A 4XRBA 5E8QA 4KD7A 1U71A 4NX7A 2C2SA 3IRMA 3FRBX 4QHVA 4QI9A 1RA8A 1DR4A 3D80A 1VJ3A 3EELA 3NRRA 1OHJA 4CD2A 1DDSA 4HA9A 3NZCX 1DREA 1DG8A 4QLEA 3JWFA 3EEMA 1RX8A 5HSUA 5HVEA 1M79A 1RD7A 1RA9A 4PTHA 4X5JA 1RX1A 3ZPCA 1S3VA 1DIUA 3GHVA 3QL0A 2D5NA 1PD8A 1BZFA 3F0SX 4KJJA 1AO8A 4OR7A 2W3WA 4KEBA 4QJZD 3FQVA 5CC9A 1J3JA 3K2HA 3FYWX 3QG2A 3M09A 4HOEA 4X5FA 1DHIA 1MVSA 4LAGX 1DISA 3NXOA 4DPDA 4DP3A 5HF2X 3GHCA 1JUVA 3F0XX 2CD2A 1KLKA 4PSTA 3KFYA 2HXVA 4X5IA 2ANQA 5ECCA 5HVBA 3NXYA 3N0HA 3KGYA 3FREX 5FDAA 1OHKA 3OAFA 2BL9A 3FQCA 4ECKA 2CIGA 1RA2A 4ELHA 3SA2A 3JVXA 2ITHA 3F91A 1IA4A 4KM2A 3QFXA 3DATA 3QL3A 3R33A 4PDJA 1RX9A 4ELFA 3D84X 8DFRA 4OSGA 1S3WA 3IRNA 1DR6A 3QLZA 1RX3A 4I13A 1DAJA 1ZDRA 3K47A 3NXVA 2ANOA 1IA3A 2BLBA 2C2TA 4Q0DA 4XT7A 3SRQX 3SRWX 5HPBA 2FZJA 2FZIA 1RE7A 1JOLA 4P3RA 3JWCA 3QLRA 1RF7A 3IA5A 3FL9A 1U70A 3FRDX 4FGHA 4EIZA 4XT4A 4KJLA 3I8AX 2G6VA 6DFRA 1RX7A 3EEKA 3JWMA 3ZPGA 2LF1A 3OCHA 1DYHA 3KY8A 2OBCA 4XECX 5HSRA 1RA3A 4I1NA 3TQ9A 5HF0X 3GYFA 1J3IA 2DRCA 4DFRA 1PD9A 3INVA 4XT5A 1D1GA 4XE6X 4XT6A 1HFQA 3E0BA 5HT5A 1DR2A 3JSUA 1YHOA 1QZFA 2D0KA 4KM0A 3TQAA 2H2QA 1DHJA 1AI9A 1DLSA 1JOMA 3CL9A 4M7VA 4EIGA 1KMVA 5JG0X 1DG5A 1CZ3A 3DG8A 4LEKX 3NZDA 4M6JA 2BLCA 3SH2A 4LAHX 3NZ6X 4XT8A 2W9TA 2W9HA 4EJ1A 3FY9X 1DYRA 3IA4A 3SAIA 4HA7A 1J3KA 4G3MA 4H97A 3FS6A 1TDRA 3S9UA 3UM8A 3F0BX 4H98A 1DR1A 3CLBA 3FL8A 3NXRA 1CD2A 7DFRA 3F0QX 3FQOA 1RX2A 5DFRA 3UM6A 2QK8A 1SEJA 2JYBA 3DGAA 4P3QA 1LY3A 3SQYX 3JW5A 5DXVA 2HM9A 2W3BA 4M7UA 1RB3A 3EIGA 4KYAA 4Q0EA 4HOGA 3FQZA 5JA3A 3KJSA 1S3UA 3FQFA 3NZAX 3DRCA 3SA1A 4ELEA 1DRBA 4QJCA 1DRAA 3VCOA 4IXED 1LY4A 2O7PA 3TD8A 5HQYA 3CSEA 1RA1A 3K45A 3HJ3A 3Q1HA 2OIPA 5HQZA 3L3RA 5EAJA 3ROAA 3JWKA 1RX6A 3TQ8A 4FHBA 3F0VX 3JTWA 3FYVX 3F8ZA 3FRFX 1HFRA 2DHFA 3GHWA 4H96A 4X5HA 3DL5A 3SRRX 1AOEA 4FGGA 1RC4A 4RGCA 1VDRA 5U26A 4PTJA 1DHFA 3F0UX 1IA1A 1E26A 3S3VA 4QLFA 3UM5A 4QLGA 3RO9A 2BLAA 3FRAX 1DG7A 4PSSA 1DR7A 4KBNA 4IXGX 2W3VA 4KJKA 3DAUA 3CD2A 3NXXA 4KNEA 4G95A 3SRUX 1RG7A 5CCCA 4LAEX 3DL6A 2L28A 4IXFX 2B3ZA 1S3YA 4G8ZX 2ZZAA 4ELBA 1RB2A 1BOZA 1M78A 1MVTA 4Q67A 1DYIA 3QGTA 2W3AA 3HBBA 3QYLA 3NZBX 3QLSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RH3 A;  3F8Y A;  4KY4 A;  1U72 A;  1DRF A;  5U27 A;  2GD9 A;  1DDR A;  3QLX A;  2W3M A;  4M6K A;  4DPH A;  4EIL A;  3IRO A;  2XW7 A;  4KAK A;  1M7A A;  2AZN A;  2KGK A;  2P4G A;  1DLR A;  3S7A A;  4NX6 A;  1LUD A;  4M6L A;  1RX4 A;  3GI2 A;  2W9G A;  4KFJ A;  3FQ0 A;  3NXT A;  1IA2 A;  5HUI A;  3LG4 A;  5HT4 A;  4M2X A;  3TQB A;  3IX9 A;  2HQP A;  3I3R A;  4GH8 A;  4KLX A;  4P68 A;  4KY8 A;  1DRH A;  1DR5 A;  4H95 A;  3KJR A;  3K74 A;  3QLW A;  4ELG A;  4PSY A;  3JW3 A;  3SR5 X;  4KL9 A;  3M08 A;  1DYJ A;  3RG9 A;  2W9S A;  4P66 A;  2FZH A;  1DR3 A;  5ECX A;  3NTZ A;  1HFP A;  3NU0 A;  1KMS A;  3SRS X;  1DF7 A;  3QYO A;  3DFR A;  4TU5 X;  4X5G A;  4DDR A;  3SGY A;  5HI6 A;  3EEJ A;  4HOF A;  3NZ9 X;  1PDB A;  3QLY A;  3FY8 X;  2INQ A;  1RX5 A;  4Q6A A;  3EX8 A;  4XRB A;  5E8Q A;  4KD7 A;  1U71 A;  4NX7 A;  2C2S A;  3IRM A;  3FRB X;  4QHV A;  4QI9 A;  1RA8 A;  1DR4 A;  3D80 A;  1VJ3 A;  3EEL A;  3NRR A;  1OHJ A;  4CD2 A;  1DDS A;  4HA9 A;  3NZC X;  1DRE A;  1DG8 A;  4QLE A;  3JWF A;  3EEM A;  1RX8 A;  5HSU A;  5HVE A;  1M79 A;  1RD7 A;  1RA9 A;  4PTH A;  4X5J A;  1RX1 A;  3ZPC A;  1S3V A;  1DIU A;  3GHV A;  3QL0 A;  2D5N A;  1PD8 A;  1BZF A;  3F0S X;  4KJJ A;  1AO8 A;  4OR7 A;  2W3W A;  4KEB A;  4QJZ D;  3FQV A;  5CC9 A;  1J3J A;  3K2H A;  3FYW X;  3QG2 A;  3M09 A;  4HOE A;  4X5F A;  1DHI A;  1MVS A;  4LAG X;  1DIS A;  3NXO A;  4DPD A;  4DP3 A;  5HF2 X;  3GHC A;  1JUV A;  3F0X X;  2CD2 A;  1KLK A;  4PST A;  3KFY A;  2HXV A;  4X5I A;  2ANQ A;  5ECC A;  5HVB A;  3NXY A;  3N0H A;  3KGY A;  3FRE X;  5FDA A;  1OHK A;  3OAF A;  2BL9 A;  3FQC A;  4ECK A;  2CIG A;  1RA2 A;  4ELH A;  3SA2 A;  3JVX A;  2ITH A;  3F91 A;  1IA4 A;  4KM2 A;  3QFX A;  3DAT A;  3QL3 A;  3R33 A;  4PDJ A;  1RX9 A;  4ELF A;  3D84 X;  8DFR A;  4OSG A;  1S3W A;  3IRN A;  1DR6 A;  3QLZ A;  1RX3 A;  4I13 A;  1DAJ A;  1ZDR A;  3K47 A;  3NXV A;  2ANO A;  1IA3 A;  2BLB A;  2C2T A;  4Q0D A;  4XT7 A;  3SRQ X;  3SRW X;  5HPB A;  2FZJ A;  2FZI A;  1RE7 A;  1JOL A;  4P3R A;  3JWC A;  3QLR A;  1RF7 A;  3IA5 A;  3FL9 A;  1U70 A;  3FRD X;  4FGH A;  4EIZ A;  4XT4 A;  4KJL A;  3I8A X;  2G6V A;  6DFR A;  1RX7 A;  3EEK A;  3JWM A;  3ZPG A;  2LF1 A;  3OCH A;  1DYH A;  3KY8 A;  2OBC A;  4XEC X;  5HSR A;  1RA3 A;  4I1N A;  3TQ9 A;  5HF0 X;  3GYF A;  1J3I A;  2DRC A;  4DFR A;  1PD9 A;  3INV A;  4XT5 A;  1D1G A;  4XE6 X;  4XT6 A;  1HFQ A;  3E0B A;  5HT5 A;  1DR2 A;  3JSU A;  1YHO A;  1QZF A;  2D0K A;  4KM0 A;  3TQA A;  2H2Q A;  1DHJ A;  1AI9 A;  1DLS A;  1JOM A;  3CL9 A;  4M7V A;  4EIG A;  1KMV A;  5JG0 X;  1DG5 A;  1CZ3 A;  3DG8 A;  4LEK X;  3NZD A;  4M6J A;  2BLC A;  3SH2 A;  4LAH X;  3NZ6 X;  4XT8 A;  2W9T A;  2W9H A;  4EJ1 A;  3FY9 X;  1DYR A;  3IA4 A;  3SAI A;  4HA7 A;  1J3K A;  4G3M A;  4H97 A;  3FS6 A;  1TDR A;  3S9U A;  3UM8 A;  3F0B X;  4H98 A;  1DR1 A;  3CLB A;  3FL8 A;  3NXR A;  1CD2 A;  7DFR A;  3F0Q X;  3FQO A;  1RX2 A;  5DFR A;  3UM6 A;  2QK8 A;  1SEJ A;  2JYB A;  3DGA A;  4P3Q A;  1LY3 A;  3SQY X;  3JW5 A;  5DXV A;  2HM9 A;  2W3B A;  4M7U A;  1RB3 A;  3EIG A;  4KYA A;  4Q0E A;  4HOG A;  3FQZ A;  5JA3 A;  3KJS A;  1S3U A;  3FQF A;  3NZA X;  3DRC A;  3SA1 A;  4ELE A;  1DRB A;  4QJC A;  1DRA A;  3VCO A;  4IXE D;  1LY4 A;  2O7P A;  3TD8 A;  5HQY A;  3CSE A;  1RA1 A;  3K45 A;  3HJ3 A;  3Q1H A;  2OIP A;  5HQZ A;  3L3R A;  5EAJ A;  3ROA A;  3JWK A;  1RX6 A;  3TQ8 A;  4FHB A;  3F0V X;  3JTW A;  3FYV X;  3F8Z A;  3FRF X;  1HFR A;  2DHF A;  3GHW A;  4H96 A;  4X5H A;  3DL5 A;  3SRR X;  1AOE A;  4FGG A;  1RC4 A;  4RGC A;  1VDR A;  5U26 A;  4PTJ A;  1DHF A;  3F0U X;  1IA1 A;  1E26 A;  3S3V A;  4QLF A;  3UM5 A;  4QLG A;  3RO9 A;  2BLA A;  3FRA X;  1DG7 A;  4PSS A;  1DR7 A;  4KBN A;  4IXG X;  2W3V A;  4KJK A;  3DAU A;  3CD2 A;  3NXX A;  4KNE A;  4G95 A;  3SRU X;  1RG7 A;  5CCC A;  4LAE X;  3DL6 A;  2L28 A;  4IXF X;  2B3Z A;  1S3Y A;  4G8Z X;  2ZZA A;  4ELB A;  1RB2 A;  1BOZ A;  1M78 A;  1MVT A;  4Q67 A;  1DYI A;  3QGT A;  2W3A A;  3HBB A;  3QYL A;  3NZB X;  3QLS A; 
#chains in the Genus database with same CATH topology
 1RH3 A;  3F8Y A;  4KY4 A;  1U72 A;  1DRF A;  5U27 A;  2GD9 A;  1DDR A;  3QLX A;  2W3M A;  4M6K A;  4DPH A;  4EIL A;  3IRO A;  2XW7 A;  4KAK A;  1M7A A;  2AZN A;  2KGK A;  2P4G A;  1DLR A;  3S7A A;  4NX6 A;  1LUD A;  4M6L A;  1RX4 A;  3GI2 A;  2W9G A;  4KFJ A;  3FQ0 A;  3NXT A;  1IA2 A;  5HUI A;  3LG4 A;  5HT4 A;  4M2X A;  3TQB A;  3IX9 A;  2HQP A;  3I3R A;  4GH8 A;  4KLX A;  4P68 A;  4KY8 A;  1DRH A;  1DR5 A;  4H95 A;  3KJR A;  3K74 A;  3QLW A;  4ELG A;  4PSY A;  3JW3 A;  3SR5 X;  4KL9 A;  3M08 A;  1DYJ A;  3RG9 A;  2W9S A;  4P66 A;  2FZH A;  1DR3 A;  5ECX A;  3NTZ A;  1HFP A;  3NU0 A;  1KMS A;  3SRS X;  1DF7 A;  3QYO A;  3DFR A;  4TU5 X;  4X5G A;  4DDR A;  3SGY A;  5HI6 A;  3EEJ A;  4HOF A;  3NZ9 X;  1PDB A;  3QLY A;  3FY8 X;  2INQ A;  1RX5 A;  4Q6A A;  3EX8 A;  4XRB A;  5E8Q A;  4KD7 A;  1U71 A;  4NX7 A;  2C2S A;  3IRM A;  3FRB X;  4QHV A;  4QI9 A;  1RA8 A;  1DR4 A;  3D80 A;  1VJ3 A;  3EEL A;  3NRR A;  1OHJ A;  4CD2 A;  1DDS A;  4HA9 A;  3NZC X;  1DRE A;  1DG8 A;  4QLE A;  3JWF A;  3EEM A;  1RX8 A;  5HSU A;  5HVE A;  1M79 A;  1RD7 A;  1RA9 A;  4PTH A;  4X5J A;  1RX1 A;  3ZPC A;  1S3V A;  1DIU A;  3GHV A;  3QL0 A;  2D5N A;  1PD8 A;  1BZF A;  3F0S X;  4KJJ A;  1AO8 A;  4OR7 A;  2W3W A;  4KEB A;  4QJZ D;  3FQV A;  5CC9 A;  1J3J A;  3K2H A;  3FYW X;  3QG2 A;  3M09 A;  4HOE A;  4X5F A;  1DHI A;  1MVS A;  4LAG X;  1DIS A;  3NXO A;  4DPD A;  4DP3 A;  5HF2 X;  3GHC A;  1JUV A;  3F0X X;  2CD2 A;  1KLK A;  4PST A;  3KFY A;  2HXV A;  4X5I A;  2ANQ A;  5ECC A;  5HVB A;  3NXY A;  3N0H A;  3KGY A;  3FRE X;  5FDA A;  1OHK A;  3OAF A;  2BL9 A;  3FQC A;  4ECK A;  2CIG A;  1RA2 A;  4ELH A;  3SA2 A;  3JVX A;  2ITH A;  3F91 A;  1IA4 A;  4KM2 A;  3QFX A;  3DAT A;  3QL3 A;  3R33 A;  4PDJ A;  1RX9 A;  4ELF A;  3D84 X;  8DFR A;  4OSG A;  1S3W A;  3IRN A;  1DR6 A;  3QLZ A;  1RX3 A;  4I13 A;  1DAJ A;  1ZDR A;  3K47 A;  3NXV A;  2ANO A;  1IA3 A;  2BLB A;  2C2T A;  4Q0D A;  4XT7 A;  3SRQ X;  3SRW X;  5HPB A;  2FZJ A;  2FZI A;  1RE7 A;  1JOL A;  4P3R A;  3JWC A;  3QLR A;  1RF7 A;  3IA5 A;  3FL9 A;  1U70 A;  3FRD X;  4FGH A;  4EIZ A;  4XT4 A;  4KJL A;  3I8A X;  2G6V A;  6DFR A;  1RX7 A;  3EEK A;  3JWM A;  3ZPG A;  2LF1 A;  3OCH A;  1DYH A;  3KY8 A;  2OBC A;  4XEC X;  5HSR A;  1RA3 A;  4I1N A;  3TQ9 A;  5HF0 X;  3GYF A;  1J3I A;  2DRC A;  4DFR A;  1PD9 A;  3INV A;  4XT5 A;  1D1G A;  4XE6 X;  4XT6 A;  1HFQ A;  3E0B A;  5HT5 A;  1DR2 A;  3JSU A;  1YHO A;  1QZF A;  2D0K A;  4KM0 A;  3TQA A;  2H2Q A;  1DHJ A;  1AI9 A;  1DLS A;  1JOM A;  3CL9 A;  4M7V A;  4EIG A;  1KMV A;  5JG0 X;  1DG5 A;  1CZ3 A;  3DG8 A;  4LEK X;  3NZD A;  4M6J A;  2BLC A;  3SH2 A;  4LAH X;  3NZ6 X;  4XT8 A;  2W9T A;  2W9H A;  4EJ1 A;  3FY9 X;  1DYR A;  3IA4 A;  3SAI A;  4HA7 A;  1J3K A;  4G3M A;  4H97 A;  3FS6 A;  1TDR A;  3S9U A;  3UM8 A;  3F0B X;  4H98 A;  1DR1 A;  3CLB A;  3FL8 A;  3NXR A;  1CD2 A;  7DFR A;  3F0Q X;  3FQO A;  1RX2 A;  5DFR A;  3UM6 A;  2QK8 A;  1SEJ A;  2JYB A;  3DGA A;  4P3Q A;  1LY3 A;  3SQY X;  3JW5 A;  5DXV A;  2HM9 A;  2W3B A;  4M7U A;  1RB3 A;  3EIG A;  4KYA A;  4Q0E A;  4HOG A;  3FQZ A;  5JA3 A;  3KJS A;  1S3U A;  3FQF A;  3NZA X;  3DRC A;  3SA1 A;  4ELE A;  1DRB A;  4QJC A;  1DRA A;  3VCO A;  4IXE D;  1LY4 A;  2O7P A;  3TD8 A;  5HQY A;  3CSE A;  1RA1 A;  3K45 A;  3HJ3 A;  3Q1H A;  2OIP A;  5HQZ A;  3L3R A;  5EAJ A;  3ROA A;  3JWK A;  1RX6 A;  3TQ8 A;  4FHB A;  3F0V X;  3JTW A;  3FYV X;  3F8Z A;  3FRF X;  1HFR A;  2DHF A;  3GHW A;  4H96 A;  4X5H A;  3DL5 A;  3SRR X;  1AOE A;  4FGG A;  1RC4 A;  4RGC A;  1VDR A;  5U26 A;  4PTJ A;  1DHF A;  3F0U X;  1IA1 A;  1E26 A;  3S3V A;  4QLF A;  3UM5 A;  4QLG A;  3RO9 A;  2BLA A;  3FRA X;  1DG7 A;  4PSS A;  1DR7 A;  4KBN A;  4IXG X;  2W3V A;  4KJK A;  3DAU A;  3CD2 A;  3NXX A;  4KNE A;  4G95 A;  3SRU X;  1RG7 A;  5CCC A;  4LAE X;  3DL6 A;  2L28 A;  4IXF X;  2B3Z A;  1S3Y A;  4G8Z X;  2ZZA A;  4ELB A;  1RB2 A;  1BOZ A;  1M78 A;  1MVT A;  4Q67 A;  1DYI A;  3QGT A;  2W3A A;  3HBB A;  3QYL A;  3NZB X;  3QLS A; 
#chains in the Genus database with same CATH homology
 1RH3 A;  3F8Y A;  4KY4 A;  1U72 A;  1DRF A;  5U27 A;  2GD9 A;  1DDR A;  3QLX A;  2W3M A;  4M6K A;  4DPH A;  4EIL A;  3IRO A;  2XW7 A;  4KAK A;  1M7A A;  2AZN A;  2KGK A;  2P4G A;  1DLR A;  3S7A A;  4NX6 A;  1LUD A;  4M6L A;  1RX4 A;  3GI2 A;  2W9G A;  4KFJ A;  3FQ0 A;  3NXT A;  1IA2 A;  5HUI A;  3LG4 A;  5HT4 A;  4M2X A;  3TQB A;  3IX9 A;  2HQP A;  3I3R A;  4GH8 A;  4KLX A;  4P68 A;  4KY8 A;  1DRH A;  1DR5 A;  4H95 A;  3KJR A;  3K74 A;  3QLW A;  4ELG A;  4PSY A;  3JW3 A;  3SR5 X;  4KL9 A;  3M08 A;  1DYJ A;  3RG9 A;  2W9S A;  4P66 A;  2FZH A;  1DR3 A;  5ECX A;  3NTZ A;  1HFP A;  3NU0 A;  1KMS A;  3SRS X;  1DF7 A;  3QYO A;  3DFR A;  4TU5 X;  4X5G A;  4DDR A;  3SGY A;  5HI6 A;  3EEJ A;  4HOF A;  3NZ9 X;  1PDB A;  3QLY A;  3FY8 X;  2INQ A;  1RX5 A;  4Q6A A;  3EX8 A;  4XRB A;  5E8Q A;  4KD7 A;  1U71 A;  4NX7 A;  2C2S A;  3IRM A;  3FRB X;  4QHV A;  4QI9 A;  1RA8 A;  1DR4 A;  3D80 A;  1VJ3 A;  3EEL A;  3NRR A;  1OHJ A;  4CD2 A;  1DDS A;  4HA9 A;  3NZC X;  1DRE A;  1DG8 A;  4QLE A;  3JWF A;  3EEM A;  1RX8 A;  5HSU A;  5HVE A;  1M79 A;  1RD7 A;  1RA9 A;  4PTH A;  4X5J A;  1RX1 A;  3ZPC A;  1S3V A;  1DIU A;  3GHV A;  3QL0 A;  2D5N A;  1PD8 A;  1BZF A;  3F0S X;  4KJJ A;  1AO8 A;  4OR7 A;  2W3W A;  4KEB A;  4QJZ D;  3FQV A;  5CC9 A;  1J3J A;  3K2H A;  3FYW X;  3QG2 A;  3M09 A;  4HOE A;  4X5F A;  1DHI A;  1MVS A;  4LAG X;  1DIS A;  3NXO A;  4DPD A;  4DP3 A;  5HF2 X;  3GHC A;  1JUV A;  3F0X X;  2CD2 A;  1KLK A;  4PST A;  3KFY A;  2HXV A;  4X5I A;  2ANQ A;  5ECC A;  5HVB A;  3NXY A;  3N0H A;  3KGY A;  3FRE X;  5FDA A;  1OHK A;  3OAF A;  2BL9 A;  3FQC A;  4ECK A;  2CIG A;  1RA2 A;  4ELH A;  3SA2 A;  3JVX A;  2ITH A;  3F91 A;  1IA4 A;  4KM2 A;  3QFX A;  3DAT A;  3QL3 A;  3R33 A;  4PDJ A;  1RX9 A;  4ELF A;  3D84 X;  8DFR A;  4OSG A;  1S3W A;  3IRN A;  1DR6 A;  3QLZ A;  1RX3 A;  4I13 A;  1DAJ A;  1ZDR A;  3K47 A;  3NXV A;  2ANO A;  1IA3 A;  2BLB A;  2C2T A;  4Q0D A;  4XT7 A;  3SRQ X;  3SRW X;  5HPB A;  2FZJ A;  2FZI A;  1RE7 A;  1JOL A;  4P3R A;  3JWC A;  3QLR A;  1RF7 A;  3IA5 A;  3FL9 A;  1U70 A;  3FRD X;  4FGH A;  4EIZ A;  4XT4 A;  4KJL A;  3I8A X;  2G6V A;  6DFR A;  1RX7 A;  3EEK A;  3JWM A;  3ZPG A;  2LF1 A;  3OCH A;  1DYH A;  3KY8 A;  2OBC A;  4XEC X;  5HSR A;  1RA3 A;  4I1N A;  3TQ9 A;  5HF0 X;  3GYF A;  1J3I A;  2DRC A;  4DFR A;  1PD9 A;  3INV A;  4XT5 A;  1D1G A;  4XE6 X;  4XT6 A;  1HFQ A;  3E0B A;  5HT5 A;  1DR2 A;  3JSU A;  1YHO A;  1QZF A;  2D0K A;  4KM0 A;  3TQA A;  2H2Q A;  1DHJ A;  1AI9 A;  1DLS A;  1JOM A;  3CL9 A;  4M7V A;  4EIG A;  1KMV A;  5JG0 X;  1DG5 A;  1CZ3 A;  3DG8 A;  4LEK X;  3NZD A;  4M6J A;  2BLC A;  3SH2 A;  4LAH X;  3NZ6 X;  4XT8 A;  2W9T A;  2W9H A;  4EJ1 A;  3FY9 X;  1DYR A;  3IA4 A;  3SAI A;  4HA7 A;  1J3K A;  4G3M A;  4H97 A;  3FS6 A;  1TDR A;  3S9U A;  3UM8 A;  3F0B X;  4H98 A;  1DR1 A;  3CLB A;  3FL8 A;  3NXR A;  1CD2 A;  7DFR A;  3F0Q X;  3FQO A;  1RX2 A;  5DFR A;  3UM6 A;  2QK8 A;  1SEJ A;  2JYB A;  3DGA A;  4P3Q A;  1LY3 A;  3SQY X;  3JW5 A;  5DXV A;  2HM9 A;  2W3B A;  4M7U A;  1RB3 A;  3EIG A;  4KYA A;  4Q0E A;  4HOG A;  3FQZ A;  5JA3 A;  3KJS A;  1S3U A;  3FQF A;  3NZA X;  3DRC A;  3SA1 A;  4ELE A;  1DRB A;  4QJC A;  1DRA A;  3VCO A;  4IXE D;  1LY4 A;  2O7P A;  3TD8 A;  5HQY A;  3CSE A;  1RA1 A;  3K45 A;  3HJ3 A;  3Q1H A;  2OIP A;  5HQZ A;  3L3R A;  5EAJ A;  3ROA A;  3JWK A;  1RX6 A;  3TQ8 A;  4FHB A;  3F0V X;  3JTW A;  3FYV X;  3F8Z A;  3FRF X;  1HFR A;  2DHF A;  3GHW A;  4H96 A;  4X5H A;  3DL5 A;  3SRR X;  1AOE A;  4FGG A;  1RC4 A;  4RGC A;  1VDR A;  5U26 A;  4PTJ A;  1DHF A;  3F0U X;  1IA1 A;  1E26 A;  3S3V A;  4QLF A;  3UM5 A;  4QLG A;  3RO9 A;  2BLA A;  3FRA X;  1DG7 A;  4PSS A;  1DR7 A;  4KBN A;  4IXG X;  2W3V A;  4KJK A;  3DAU A;  3CD2 A;  3NXX A;  4KNE A;  4G95 A;  3SRU X;  1RG7 A;  5CCC A;  4LAE X;  3DL6 A;  2L28 A;  4IXF X;  2B3Z A;  1S3Y A;  4G8Z X;  2ZZA A;  4ELB A;  1RB2 A;  1BOZ A;  1M78 A;  1MVT A;  4Q67 A;  1DYI A;  3QGT A;  2W3A A;  3HBB A;  3QYL A;  3NZB X;  3QLS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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