4KM2A

Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in an open conformation in complex with trimethoprim
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
159
structure length
159
Chain Sequence
MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Mycobacterium tuberculosis
molecule keywords Dihydrofolate reductase
total genus 42
structure length 159
sequence length 159
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4km2A00
3JSUA 3I8AX 3L3RA 4X5HA 1DR6A 2QK8A 1CD2A 4KM2A 1J3KA 2FZIA 5HUIA 3S7AA 3FQ0A 3QLXA 4LAEX 2D0KA 5HVEA 3NRRA 2BLBA 3FL8A 3EIGA 2W3AA 1RF7A 4G8ZX 1DR2A 3SR5X 1DR4A 1S3UA 3F0UX 3DFRA 3FQVA 3D84X 3QLWA 4Q0DA 3FL9A 4M7VA 4PTJA 3SAIA 1MVSA 3SRSX 4XT6A 3FRFX 2C2TA 5HSRA 3K74A 3FRDX 4HOGA 2JYBA 3QL3A 4M6KA 3SQYX 2OBCA 1J3IA 4LAGX 3HBBA 4KLXA 2W9GA 4KFJA 1SEJA 4X5GA 4P66A 3SGYA 3QYLA 4H98A 3FQFA 1LY3A 3KJRA 4ELEA 2W9HA 6DFRA 1RE7A 4KNEA 4KAKA 4FGHA 3ROAA 1DF7A 1DRHA 3FRBX 3UM8A 1U71A 2LF1A 4PSSA 2INQA 1RA9A 3RO9A 1RX9A 3KGYA 3I3RA 1HFRA 1BOZA 4HOEA 5HI6A 3FREX 3NXRA 1M79A 4Q67A 1AOEA 1AO8A 1RX1A 2CIGA 4IXGX 2W3VA 2AZNA 1DISA 2G6VA 2OIPA 4DPHA 4XRBA 1DLSA 3EEJA 3LG4A 3IROA 2DRCA 3FRAX 1JOMA 3EX8A 4QI9A 1DR7A 3NXVA 3NZBX 1S3YA 3JW5A 3SRQX 4KD7A 1RB2A 3QYOA 4LAHX 5JA3A 4P3RA 1TDRA 1U72A 3FYWX 4XT5A 2DHFA 3UM6A 2HQPA 3ZPGA 1KLKA 3SRRX 3S3VA 3GYFA 3SA2A 1LY4A 1RA2A 2ANQA 2D5NA 4M7UA 4RGCA 4DDRA 4H97A 2XW7A 3CL9A 5DXVA 3QFXA 5HQYA 4ELGA 5HVBA 3NZAX 1RX4A 3NU0A 3M08A 4DP3A 1ZDRA 1RH3A 1PD9A 4H96A 3TD8A 4I13A 3F0XX 1AI9A 1DAJA 1DLRA 4Q6AA 3GHCA 3SH2A 1IA4A 3UM5A 1RX3A 1J3JA 3IX9A 1IA1A 3QLYA 4KJJA 4EIZA 5HQZA 4X5JA 4XT7A 2CD2A 4M2XA 1RA8A 5EAJA 3NXTA 3TQBA 5ECXA 1D1GA 3QL0A 4NX6A 3OAFA 3QLRA 1RC4A 3GHVA 4X5IA 1RA1A 3K2HA 3JWMA 4Q0EA 3TQAA 3S9UA 2BLAA 3F8YA 3CD2A 4KEBA 3K45A 4DFRA 1DHFA 1KMVA 5JG0X 2ITHA 4HOFA 3QGTA 4HA7A 3K47A 1RD7A 3DG8A 1RX2A 2FZHA 4ECKA 3NZ6X 3IRMA 5DFRA 2GD9A 3TQ8A 4QLGA 3RG9A 3CSEA 2B3ZA 3EEKA 3FQOA 2W3WA 1DYRA 1KMSA 4GH8A 1DYIA 4G3MA 1LUDA 3DATA 3NXXA 3FQCA 4PSTA 1DG7A 1E26A 4M6LA 1RX7A 3KJSA 4G95A 3DGAA 1OHKA 4P3QA 4ELHA 4PSYA 3FYVX 3FY9X 4QJZD 4ELBA 3GHWA 2W9SA 5CCCA 5HF2X 4I1NA 4EJ1A 4KBNA 3JW3A 3FY8X 5U26A 3FQZA 4QHVA 4QLFA 1DRBA 1DDSA 4KYAA 1U70A 4XECX 4TU5X 4XT8A 3NXOA 5HPBA 3CLBA 1RG7A 5FDAA 3Q1HA 1DRAA 2ZZAA 1DDRA 2O7PA 5HSUA 1DG8A 1S3WA 3QG2A 4KY8A 4DPDA 1DR3A 1DRFA 1DR5A 1RB3A 1DYJA 7DFRA 3R33A 4LEKX 4FGGA 3JWKA 4EIGA 4NX7A 4IXFX 1CZ3A 3IA4A 3ZPCA 5HF0X 1DHIA 4KM0A 3F8ZA 3OCHA 3NXYA 4ELFA 1DHJA 5CC9A 4QLEA 4KJLA 3IRNA 3N0HA 1IA3A 4H95A 3QLSA 1QZFA 5ECCA 4QJCA 3F91A 3DL6A 1RX8A 4KJKA 4KL9A 2W9TA 3JWFA 3KFYA 4P68A 5HT4A 1DG5A 4IXED 8DFRA 3F0BX 3DAUA 3EELA 1DIUA 3NZ9X 3SRWX 1JUVA 4XT4A 2ANOA 3INVA 2W3MA 4M6JA 3EEMA 3GI2A 3VCOA 4EILA 1VJ3A 3F0VX 2BL9A 3JWCA 3QLZA 3DRCA 5HT5A 3SA1A 1VDRA 2HXVA 2W3BA 1S3VA 3M09A 4HA9A 1BZFA 3KY8A 3NZCX 4KY4A 3DL5A 2H2QA 4OSGA 2BLCA 1YHOA 4PTHA 3D80A 3NTZA 4X5FA 1HFPA 1DYHA 1RX5A 3NZDA 4XE6X 1PDBA 1IA2A 3E0BA 1DR1A 2KGKA 4OR7A 4FHBA 5E8QA 3HJ3A 3JTWA 1JOLA 3SRUX 3IA5A 3F0SX 2FZJA 1HFQA 1M7AA 4CD2A 2P4GA 1M78A 5U27A 2C2SA 1RA3A 3F0QX 3FS6A 2HM9A 4PDJA 1MVTA 1RX6A 1PD8A 3JVXA 1DREA 3TQ9A 1OHJA 2L28A
chains in the Genus database with same CATH superfamily
3JSUA 3I8AX 3L3RA 4X5HA 1DR6A 2QK8A 1CD2A 4KM2A 1J3KA 2FZIA 5HUIA 3S7AA 3FQ0A 3QLXA 4LAEX 2D0KA 5HVEA 3NRRA 2BLBA 3FL8A 3EIGA 2W3AA 1RF7A 4G8ZX 1DR2A 3SR5X 1DR4A 1S3UA 3F0UX 3DFRA 3FQVA 3D84X 3QLWA 4Q0DA 3FL9A 4M7VA 4PTJA 3SAIA 1MVSA 3SRSX 4XT6A 3FRFX 2C2TA 5HSRA 3K74A 3FRDX 4HOGA 2JYBA 3QL3A 4M6KA 3SQYX 2OBCA 1J3IA 4LAGX 3HBBA 4KLXA 2W9GA 4KFJA 1SEJA 4X5GA 4P66A 3SGYA 3QYLA 4H98A 3FQFA 1LY3A 3KJRA 4ELEA 2W9HA 6DFRA 1RE7A 4KNEA 4KAKA 4FGHA 3ROAA 1DF7A 1DRHA 3FRBX 3UM8A 1U71A 2LF1A 4PSSA 2INQA 1RA9A 3RO9A 1RX9A 3KGYA 3I3RA 1HFRA 1BOZA 4HOEA 5HI6A 3FREX 3NXRA 1M79A 4Q67A 1AOEA 1AO8A 1RX1A 2CIGA 4IXGX 2W3VA 2AZNA 1DISA 2G6VA 2OIPA 4DPHA 4XRBA 1DLSA 3EEJA 3LG4A 3IROA 2DRCA 3FRAX 1JOMA 3EX8A 4QI9A 1DR7A 3NXVA 3NZBX 1S3YA 3JW5A 3SRQX 4KD7A 1RB2A 3QYOA 4LAHX 5JA3A 4P3RA 1TDRA 1U72A 3FYWX 4XT5A 2DHFA 3UM6A 2HQPA 3ZPGA 1KLKA 3SRRX 3S3VA 3GYFA 3SA2A 1LY4A 1RA2A 2ANQA 2D5NA 4M7UA 4RGCA 4DDRA 4H97A 2XW7A 3CL9A 5DXVA 3QFXA 5HQYA 4ELGA 5HVBA 3NZAX 1RX4A 3NU0A 3M08A 4DP3A 1ZDRA 1RH3A 1PD9A 4H96A 3TD8A 4I13A 3F0XX 1AI9A 1DAJA 1DLRA 4Q6AA 3GHCA 3SH2A 1IA4A 3UM5A 1RX3A 1J3JA 3IX9A 1IA1A 3QLYA 4KJJA 4EIZA 5HQZA 4X5JA 4XT7A 2CD2A 4M2XA 1RA8A 5EAJA 3NXTA 3TQBA 5ECXA 1D1GA 3QL0A 4NX6A 3OAFA 3QLRA 1RC4A 3GHVA 4X5IA 1RA1A 3K2HA 3JWMA 4Q0EA 3TQAA 3S9UA 2BLAA 3F8YA 3CD2A 4KEBA 3K45A 4DFRA 1DHFA 1KMVA 5JG0X 2ITHA 4HOFA 3QGTA 4HA7A 3K47A 1RD7A 3DG8A 1RX2A 2FZHA 4ECKA 3NZ6X 3IRMA 5DFRA 2GD9A 3TQ8A 4QLGA 3RG9A 3CSEA 2B3ZA 3EEKA 3FQOA 2W3WA 1DYRA 1KMSA 4GH8A 1DYIA 4G3MA 1LUDA 3DATA 3NXXA 3FQCA 4PSTA 1DG7A 1E26A 4M6LA 1RX7A 3KJSA 4G95A 3DGAA 1OHKA 4P3QA 4ELHA 4PSYA 3FYVX 3FY9X 4QJZD 4ELBA 3GHWA 2W9SA 5CCCA 5HF2X 4I1NA 4EJ1A 4KBNA 3JW3A 3FY8X 5U26A 3FQZA 4QHVA 4QLFA 1DRBA 1DDSA 4KYAA 1U70A 4XECX 4TU5X 4XT8A 3NXOA 5HPBA 3CLBA 1RG7A 5FDAA 3Q1HA 1DRAA 2ZZAA 1DDRA 2O7PA 5HSUA 1DG8A 1S3WA 3QG2A 4KY8A 4DPDA 1DR3A 1DRFA 1DR5A 1RB3A 1DYJA 7DFRA 3R33A 4LEKX 4FGGA 3JWKA 4EIGA 4NX7A 4IXFX 1CZ3A 3IA4A 3ZPCA 5HF0X 1DHIA 4KM0A 3F8ZA 3OCHA 3NXYA 4ELFA 1DHJA 5CC9A 4QLEA 4KJLA 3IRNA 3N0HA 1IA3A 4H95A 3QLSA 1QZFA 5ECCA 4QJCA 3F91A 3DL6A 1RX8A 4KJKA 4KL9A 2W9TA 3JWFA 3KFYA 4P68A 5HT4A 1DG5A 4IXED 8DFRA 3F0BX 3DAUA 3EELA 1DIUA 3NZ9X 3SRWX 1JUVA 4XT4A 2ANOA 3INVA 2W3MA 4M6JA 3EEMA 3GI2A 3VCOA 4EILA 1VJ3A 3F0VX 2BL9A 3JWCA 3QLZA 3DRCA 5HT5A 3SA1A 1VDRA 2HXVA 2W3BA 1S3VA 3M09A 4HA9A 1BZFA 3KY8A 3NZCX 4KY4A 3DL5A 2H2QA 4OSGA 2BLCA 1YHOA 4PTHA 3D80A 3NTZA 4X5FA 1HFPA 1DYHA 1RX5A 3NZDA 4XE6X 1PDBA 1IA2A 3E0BA 1DR1A 2KGKA 4OR7A 4FHBA 5E8QA 3HJ3A 3JTWA 1JOLA 3SRUX 3IA5A 3F0SX 2FZJA 1HFQA 1M7AA 4CD2A 2P4GA 1M78A 5U27A 2C2SA 1RA3A 3F0QX 3FS6A 2HM9A 4PDJA 1MVTA 1RX6A 1PD8A 3JVXA 1DREA 3TQ9A 1OHJA 2L28A
chains in the Genus database with same CATH topology
3JSUA 3I8AX 3L3RA 4X5HA 1DR6A 2QK8A 1CD2A 4KM2A 1J3KA 2FZIA 5HUIA 3S7AA 3FQ0A 3QLXA 4LAEX 2D0KA 5HVEA 3NRRA 2BLBA 3FL8A 3EIGA 2W3AA 1RF7A 4G8ZX 1DR2A 3SR5X 1DR4A 1S3UA 3F0UX 3DFRA 3FQVA 3D84X 3QLWA 4Q0DA 3FL9A 4M7VA 4PTJA 3SAIA 1MVSA 3SRSX 4XT6A 3FRFX 2C2TA 5HSRA 3K74A 3FRDX 4HOGA 2JYBA 3QL3A 4M6KA 3SQYX 2OBCA 1J3IA 4LAGX 3HBBA 4KLXA 2W9GA 4KFJA 1SEJA 4X5GA 4P66A 3SGYA 3QYLA 4H98A 3FQFA 1LY3A 3KJRA 4ELEA 2W9HA 6DFRA 1RE7A 4KNEA 4KAKA 4FGHA 3ROAA 1DF7A 1DRHA 3FRBX 3UM8A 1U71A 2LF1A 4PSSA 2INQA 1RA9A 3RO9A 1RX9A 3KGYA 3I3RA 1HFRA 1BOZA 4HOEA 5HI6A 3FREX 3NXRA 1M79A 4Q67A 1AOEA 1AO8A 1RX1A 2CIGA 4IXGX 2W3VA 2AZNA 1DISA 2G6VA 2OIPA 4DPHA 4XRBA 1DLSA 3EEJA 3LG4A 3IROA 2DRCA 3FRAX 1JOMA 3EX8A 4QI9A 1DR7A 3NXVA 3NZBX 1S3YA 3JW5A 3SRQX 4KD7A 1RB2A 3QYOA 4LAHX 5JA3A 4P3RA 1TDRA 1U72A 3FYWX 4XT5A 2DHFA 3UM6A 2HQPA 3ZPGA 1KLKA 3SRRX 3S3VA 3GYFA 3SA2A 1LY4A 1RA2A 2ANQA 2D5NA 4M7UA 4RGCA 4DDRA 4H97A 2XW7A 3CL9A 5DXVA 3QFXA 5HQYA 4ELGA 5HVBA 3NZAX 1RX4A 3NU0A 3M08A 4DP3A 1ZDRA 1RH3A 1PD9A 4H96A 3TD8A 4I13A 3F0XX 1AI9A 1DAJA 1DLRA 4Q6AA 3GHCA 3SH2A 1IA4A 3UM5A 1RX3A 1J3JA 3IX9A 1IA1A 3QLYA 4KJJA 4EIZA 5HQZA 4X5JA 4XT7A 2CD2A 4M2XA 1RA8A 5EAJA 3NXTA 3TQBA 5ECXA 1D1GA 3QL0A 4NX6A 3OAFA 3QLRA 1RC4A 3GHVA 4X5IA 1RA1A 3K2HA 3JWMA 4Q0EA 3TQAA 3S9UA 2BLAA 3F8YA 3CD2A 4KEBA 3K45A 4DFRA 1DHFA 1KMVA 5JG0X 2ITHA 4HOFA 3QGTA 4HA7A 3K47A 1RD7A 3DG8A 1RX2A 2FZHA 4ECKA 3NZ6X 3IRMA 5DFRA 2GD9A 3TQ8A 4QLGA 3RG9A 3CSEA 2B3ZA 3EEKA 3FQOA 2W3WA 1DYRA 1KMSA 4GH8A 1DYIA 4G3MA 1LUDA 3DATA 3NXXA 3FQCA 4PSTA 1DG7A 1E26A 4M6LA 1RX7A 3KJSA 4G95A 3DGAA 1OHKA 4P3QA 4ELHA 4PSYA 3FYVX 3FY9X 4QJZD 4ELBA 3GHWA 2W9SA 5CCCA 5HF2X 4I1NA 4EJ1A 4KBNA 3JW3A 3FY8X 5U26A 3FQZA 4QHVA 4QLFA 1DRBA 1DDSA 4KYAA 1U70A 4XECX 4TU5X 4XT8A 3NXOA 5HPBA 3CLBA 1RG7A 5FDAA 3Q1HA 1DRAA 2ZZAA 1DDRA 2O7PA 5HSUA 1DG8A 1S3WA 3QG2A 4KY8A 4DPDA 1DR3A 1DRFA 1DR5A 1RB3A 1DYJA 7DFRA 3R33A 4LEKX 4FGGA 3JWKA 4EIGA 4NX7A 4IXFX 1CZ3A 3IA4A 3ZPCA 5HF0X 1DHIA 4KM0A 3F8ZA 3OCHA 3NXYA 4ELFA 1DHJA 5CC9A 4QLEA 4KJLA 3IRNA 3N0HA 1IA3A 4H95A 3QLSA 1QZFA 5ECCA 4QJCA 3F91A 3DL6A 1RX8A 4KJKA 4KL9A 2W9TA 3JWFA 3KFYA 4P68A 5HT4A 1DG5A 4IXED 8DFRA 3F0BX 3DAUA 3EELA 1DIUA 3NZ9X 3SRWX 1JUVA 4XT4A 2ANOA 3INVA 2W3MA 4M6JA 3EEMA 3GI2A 3VCOA 4EILA 1VJ3A 3F0VX 2BL9A 3JWCA 3QLZA 3DRCA 5HT5A 3SA1A 1VDRA 2HXVA 2W3BA 1S3VA 3M09A 4HA9A 1BZFA 3KY8A 3NZCX 4KY4A 3DL5A 2H2QA 4OSGA 2BLCA 1YHOA 4PTHA 3D80A 3NTZA 4X5FA 1HFPA 1DYHA 1RX5A 3NZDA 4XE6X 1PDBA 1IA2A 3E0BA 1DR1A 2KGKA 4OR7A 4FHBA 5E8QA 3HJ3A 3JTWA 1JOLA 3SRUX 3IA5A 3F0SX 2FZJA 1HFQA 1M7AA 4CD2A 2P4GA 1M78A 5U27A 2C2SA 1RA3A 3F0QX 3FS6A 2HM9A 4PDJA 1MVTA 1RX6A 1PD8A 3JVXA 1DREA 3TQ9A 1OHJA 2L28A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3JSU A;  3I8A X;  3L3R A;  4X5H A;  1DR6 A;  2QK8 A;  1CD2 A;  4KM2 A;  1J3K A;  2FZI A;  5HUI A;  3S7A A;  3FQ0 A;  3QLX A;  4LAE X;  2D0K A;  5HVE A;  3NRR A;  2BLB A;  3FL8 A;  3EIG A;  2W3A A;  1RF7 A;  4G8Z X;  1DR2 A;  3SR5 X;  1DR4 A;  1S3U A;  3F0U X;  3DFR A;  3FQV A;  3D84 X;  3QLW A;  4Q0D A;  3FL9 A;  4M7V A;  4PTJ A;  3SAI A;  1MVS A;  3SRS X;  4XT6 A;  3FRF X;  2C2T A;  5HSR A;  3K74 A;  3FRD X;  4HOG A;  2JYB A;  3QL3 A;  4M6K A;  3SQY X;  2OBC A;  1J3I A;  4LAG X;  3HBB A;  4KLX A;  2W9G A;  4KFJ A;  1SEJ A;  4X5G A;  4P66 A;  3SGY A;  3QYL A;  4H98 A;  3FQF A;  1LY3 A;  3KJR A;  4ELE A;  2W9H A;  6DFR A;  1RE7 A;  4KNE A;  4KAK A;  4FGH A;  3ROA A;  1DF7 A;  1DRH A;  3FRB X;  3UM8 A;  1U71 A;  2LF1 A;  4PSS A;  2INQ A;  1RA9 A;  3RO9 A;  1RX9 A;  3KGY A;  3I3R A;  1HFR A;  1BOZ A;  4HOE A;  5HI6 A;  3FRE X;  3NXR A;  1M79 A;  4Q67 A;  1AOE A;  1AO8 A;  1RX1 A;  2CIG A;  4IXG X;  2W3V A;  2AZN A;  1DIS A;  2G6V A;  2OIP A;  4DPH A;  4XRB A;  1DLS A;  3EEJ A;  3LG4 A;  3IRO A;  2DRC A;  3FRA X;  1JOM A;  3EX8 A;  4QI9 A;  1DR7 A;  3NXV A;  3NZB X;  1S3Y A;  3JW5 A;  3SRQ X;  4KD7 A;  1RB2 A;  3QYO A;  4LAH X;  5JA3 A;  4P3R A;  1TDR A;  1U72 A;  3FYW X;  4XT5 A;  2DHF A;  3UM6 A;  2HQP A;  3ZPG A;  1KLK A;  3SRR X;  3S3V A;  3GYF A;  3SA2 A;  1LY4 A;  1RA2 A;  2ANQ A;  2D5N A;  4M7U A;  4RGC A;  4DDR A;  4H97 A;  2XW7 A;  3CL9 A;  5DXV A;  3QFX A;  5HQY A;  4ELG A;  5HVB A;  3NZA X;  1RX4 A;  3NU0 A;  3M08 A;  4DP3 A;  1ZDR A;  1RH3 A;  1PD9 A;  4H96 A;  3TD8 A;  4I13 A;  3F0X X;  1AI9 A;  1DAJ A;  1DLR A;  4Q6A A;  3GHC A;  3SH2 A;  1IA4 A;  3UM5 A;  1RX3 A;  1J3J A;  3IX9 A;  1IA1 A;  3QLY A;  4KJJ A;  4EIZ A;  5HQZ A;  4X5J A;  4XT7 A;  2CD2 A;  4M2X A;  1RA8 A;  5EAJ A;  3NXT A;  3TQB A;  5ECX A;  1D1G A;  3QL0 A;  4NX6 A;  3OAF A;  3QLR A;  1RC4 A;  3GHV A;  4X5I A;  1RA1 A;  3K2H A;  3JWM A;  4Q0E A;  3TQA A;  3S9U A;  2BLA A;  3F8Y A;  3CD2 A;  4KEB A;  3K45 A;  4DFR A;  1DHF A;  1KMV A;  5JG0 X;  2ITH A;  4HOF A;  3QGT A;  4HA7 A;  3K47 A;  1RD7 A;  3DG8 A;  1RX2 A;  2FZH A;  4ECK A;  3NZ6 X;  3IRM A;  5DFR A;  2GD9 A;  3TQ8 A;  4QLG A;  3RG9 A;  3CSE A;  2B3Z A;  3EEK A;  3FQO A;  2W3W A;  1DYR A;  1KMS A;  4GH8 A;  1DYI A;  4G3M A;  1LUD A;  3DAT A;  3NXX A;  3FQC A;  4PST A;  1DG7 A;  1E26 A;  4M6L A;  1RX7 A;  3KJS A;  4G95 A;  3DGA A;  1OHK A;  4P3Q A;  4ELH A;  4PSY A;  3FYV X;  3FY9 X;  4QJZ D;  4ELB A;  3GHW A;  2W9S A;  5CCC A;  5HF2 X;  4I1N A;  4EJ1 A;  4KBN A;  3JW3 A;  3FY8 X;  5U26 A;  3FQZ A;  4QHV A;  4QLF A;  1DRB A;  1DDS A;  4KYA A;  1U70 A;  4XEC X;  4TU5 X;  4XT8 A;  3NXO A;  5HPB A;  3CLB A;  1RG7 A;  5FDA A;  3Q1H A;  1DRA A;  2ZZA A;  1DDR A;  2O7P A;  5HSU A;  1DG8 A;  1S3W A;  3QG2 A;  4KY8 A;  4DPD A;  1DR3 A;  1DRF A;  1DR5 A;  1RB3 A;  1DYJ A;  7DFR A;  3R33 A;  4LEK X;  4FGG A;  3JWK A;  4EIG A;  4NX7 A;  4IXF X;  1CZ3 A;  3IA4 A;  3ZPC A;  5HF0 X;  1DHI A;  4KM0 A;  3F8Z A;  3OCH A;  3NXY A;  4ELF A;  1DHJ A;  5CC9 A;  4QLE A;  4KJL A;  3IRN A;  3N0H A;  1IA3 A;  4H95 A;  3QLS A;  1QZF A;  5ECC A;  4QJC A;  3F91 A;  3DL6 A;  1RX8 A;  4KJK A;  4KL9 A;  2W9T A;  3JWF A;  3KFY A;  4P68 A;  5HT4 A;  1DG5 A;  4IXE D;  8DFR A;  3F0B X;  3DAU A;  3EEL A;  1DIU A;  3NZ9 X;  3SRW X;  1JUV A;  4XT4 A;  2ANO A;  3INV A;  2W3M A;  4M6J A;  3EEM A;  3GI2 A;  3VCO A;  4EIL A;  1VJ3 A;  3F0V X;  2BL9 A;  3JWC A;  3QLZ A;  3DRC A;  5HT5 A;  3SA1 A;  1VDR A;  2HXV A;  2W3B A;  1S3V A;  3M09 A;  4HA9 A;  1BZF A;  3KY8 A;  3NZC X;  4KY4 A;  3DL5 A;  2H2Q A;  4OSG A;  2BLC A;  1YHO A;  4PTH A;  3D80 A;  3NTZ A;  4X5F A;  1HFP A;  1DYH A;  1RX5 A;  3NZD A;  4XE6 X;  1PDB A;  1IA2 A;  3E0B A;  1DR1 A;  2KGK A;  4OR7 A;  4FHB A;  5E8Q A;  3HJ3 A;  3JTW A;  1JOL A;  3SRU X;  3IA5 A;  3F0S X;  2FZJ A;  1HFQ A;  1M7A A;  4CD2 A;  2P4G A;  1M78 A;  5U27 A;  2C2S A;  1RA3 A;  3F0Q X;  3FS6 A;  2HM9 A;  4PDJ A;  1MVT A;  1RX6 A;  1PD8 A;  3JVX A;  1DRE A;  3TQ9 A;  1OHJ A;  2L28 A; 
#chains in the Genus database with same CATH topology
 3JSU A;  3I8A X;  3L3R A;  4X5H A;  1DR6 A;  2QK8 A;  1CD2 A;  4KM2 A;  1J3K A;  2FZI A;  5HUI A;  3S7A A;  3FQ0 A;  3QLX A;  4LAE X;  2D0K A;  5HVE A;  3NRR A;  2BLB A;  3FL8 A;  3EIG A;  2W3A A;  1RF7 A;  4G8Z X;  1DR2 A;  3SR5 X;  1DR4 A;  1S3U A;  3F0U X;  3DFR A;  3FQV A;  3D84 X;  3QLW A;  4Q0D A;  3FL9 A;  4M7V A;  4PTJ A;  3SAI A;  1MVS A;  3SRS X;  4XT6 A;  3FRF X;  2C2T A;  5HSR A;  3K74 A;  3FRD X;  4HOG A;  2JYB A;  3QL3 A;  4M6K A;  3SQY X;  2OBC A;  1J3I A;  4LAG X;  3HBB A;  4KLX A;  2W9G A;  4KFJ A;  1SEJ A;  4X5G A;  4P66 A;  3SGY A;  3QYL A;  4H98 A;  3FQF A;  1LY3 A;  3KJR A;  4ELE A;  2W9H A;  6DFR A;  1RE7 A;  4KNE A;  4KAK A;  4FGH A;  3ROA A;  1DF7 A;  1DRH A;  3FRB X;  3UM8 A;  1U71 A;  2LF1 A;  4PSS A;  2INQ A;  1RA9 A;  3RO9 A;  1RX9 A;  3KGY A;  3I3R A;  1HFR A;  1BOZ A;  4HOE A;  5HI6 A;  3FRE X;  3NXR A;  1M79 A;  4Q67 A;  1AOE A;  1AO8 A;  1RX1 A;  2CIG A;  4IXG X;  2W3V A;  2AZN A;  1DIS A;  2G6V A;  2OIP A;  4DPH A;  4XRB A;  1DLS A;  3EEJ A;  3LG4 A;  3IRO A;  2DRC A;  3FRA X;  1JOM A;  3EX8 A;  4QI9 A;  1DR7 A;  3NXV A;  3NZB X;  1S3Y A;  3JW5 A;  3SRQ X;  4KD7 A;  1RB2 A;  3QYO A;  4LAH X;  5JA3 A;  4P3R A;  1TDR A;  1U72 A;  3FYW X;  4XT5 A;  2DHF A;  3UM6 A;  2HQP A;  3ZPG A;  1KLK A;  3SRR X;  3S3V A;  3GYF A;  3SA2 A;  1LY4 A;  1RA2 A;  2ANQ A;  2D5N A;  4M7U A;  4RGC A;  4DDR A;  4H97 A;  2XW7 A;  3CL9 A;  5DXV A;  3QFX A;  5HQY A;  4ELG A;  5HVB A;  3NZA X;  1RX4 A;  3NU0 A;  3M08 A;  4DP3 A;  1ZDR A;  1RH3 A;  1PD9 A;  4H96 A;  3TD8 A;  4I13 A;  3F0X X;  1AI9 A;  1DAJ A;  1DLR A;  4Q6A A;  3GHC A;  3SH2 A;  1IA4 A;  3UM5 A;  1RX3 A;  1J3J A;  3IX9 A;  1IA1 A;  3QLY A;  4KJJ A;  4EIZ A;  5HQZ A;  4X5J A;  4XT7 A;  2CD2 A;  4M2X A;  1RA8 A;  5EAJ A;  3NXT A;  3TQB A;  5ECX A;  1D1G A;  3QL0 A;  4NX6 A;  3OAF A;  3QLR A;  1RC4 A;  3GHV A;  4X5I A;  1RA1 A;  3K2H A;  3JWM A;  4Q0E A;  3TQA A;  3S9U A;  2BLA A;  3F8Y A;  3CD2 A;  4KEB A;  3K45 A;  4DFR A;  1DHF A;  1KMV A;  5JG0 X;  2ITH A;  4HOF A;  3QGT A;  4HA7 A;  3K47 A;  1RD7 A;  3DG8 A;  1RX2 A;  2FZH A;  4ECK A;  3NZ6 X;  3IRM A;  5DFR A;  2GD9 A;  3TQ8 A;  4QLG A;  3RG9 A;  3CSE A;  2B3Z A;  3EEK A;  3FQO A;  2W3W A;  1DYR A;  1KMS A;  4GH8 A;  1DYI A;  4G3M A;  1LUD A;  3DAT A;  3NXX A;  3FQC A;  4PST A;  1DG7 A;  1E26 A;  4M6L A;  1RX7 A;  3KJS A;  4G95 A;  3DGA A;  1OHK A;  4P3Q A;  4ELH A;  4PSY A;  3FYV X;  3FY9 X;  4QJZ D;  4ELB A;  3GHW A;  2W9S A;  5CCC A;  5HF2 X;  4I1N A;  4EJ1 A;  4KBN A;  3JW3 A;  3FY8 X;  5U26 A;  3FQZ A;  4QHV A;  4QLF A;  1DRB A;  1DDS A;  4KYA A;  1U70 A;  4XEC X;  4TU5 X;  4XT8 A;  3NXO A;  5HPB A;  3CLB A;  1RG7 A;  5FDA A;  3Q1H A;  1DRA A;  2ZZA A;  1DDR A;  2O7P A;  5HSU A;  1DG8 A;  1S3W A;  3QG2 A;  4KY8 A;  4DPD A;  1DR3 A;  1DRF A;  1DR5 A;  1RB3 A;  1DYJ A;  7DFR A;  3R33 A;  4LEK X;  4FGG A;  3JWK A;  4EIG A;  4NX7 A;  4IXF X;  1CZ3 A;  3IA4 A;  3ZPC A;  5HF0 X;  1DHI A;  4KM0 A;  3F8Z A;  3OCH A;  3NXY A;  4ELF A;  1DHJ A;  5CC9 A;  4QLE A;  4KJL A;  3IRN A;  3N0H A;  1IA3 A;  4H95 A;  3QLS A;  1QZF A;  5ECC A;  4QJC A;  3F91 A;  3DL6 A;  1RX8 A;  4KJK A;  4KL9 A;  2W9T A;  3JWF A;  3KFY A;  4P68 A;  5HT4 A;  1DG5 A;  4IXE D;  8DFR A;  3F0B X;  3DAU A;  3EEL A;  1DIU A;  3NZ9 X;  3SRW X;  1JUV A;  4XT4 A;  2ANO A;  3INV A;  2W3M A;  4M6J A;  3EEM A;  3GI2 A;  3VCO A;  4EIL A;  1VJ3 A;  3F0V X;  2BL9 A;  3JWC A;  3QLZ A;  3DRC A;  5HT5 A;  3SA1 A;  1VDR A;  2HXV A;  2W3B A;  1S3V A;  3M09 A;  4HA9 A;  1BZF A;  3KY8 A;  3NZC X;  4KY4 A;  3DL5 A;  2H2Q A;  4OSG A;  2BLC A;  1YHO A;  4PTH A;  3D80 A;  3NTZ A;  4X5F A;  1HFP A;  1DYH A;  1RX5 A;  3NZD A;  4XE6 X;  1PDB A;  1IA2 A;  3E0B A;  1DR1 A;  2KGK A;  4OR7 A;  4FHB A;  5E8Q A;  3HJ3 A;  3JTW A;  1JOL A;  3SRU X;  3IA5 A;  3F0S X;  2FZJ A;  1HFQ A;  1M7A A;  4CD2 A;  2P4G A;  1M78 A;  5U27 A;  2C2S A;  1RA3 A;  3F0Q X;  3FS6 A;  2HM9 A;  4PDJ A;  1MVT A;  1RX6 A;  1PD8 A;  3JVX A;  1DRE A;  3TQ9 A;  1OHJ A;  2L28 A; 
#chains in the Genus database with same CATH homology
 3JSU A;  3I8A X;  3L3R A;  4X5H A;  1DR6 A;  2QK8 A;  1CD2 A;  4KM2 A;  1J3K A;  2FZI A;  5HUI A;  3S7A A;  3FQ0 A;  3QLX A;  4LAE X;  2D0K A;  5HVE A;  3NRR A;  2BLB A;  3FL8 A;  3EIG A;  2W3A A;  1RF7 A;  4G8Z X;  1DR2 A;  3SR5 X;  1DR4 A;  1S3U A;  3F0U X;  3DFR A;  3FQV A;  3D84 X;  3QLW A;  4Q0D A;  3FL9 A;  4M7V A;  4PTJ A;  3SAI A;  1MVS A;  3SRS X;  4XT6 A;  3FRF X;  2C2T A;  5HSR A;  3K74 A;  3FRD X;  4HOG A;  2JYB A;  3QL3 A;  4M6K A;  3SQY X;  2OBC A;  1J3I A;  4LAG X;  3HBB A;  4KLX A;  2W9G A;  4KFJ A;  1SEJ A;  4X5G A;  4P66 A;  3SGY A;  3QYL A;  4H98 A;  3FQF A;  1LY3 A;  3KJR A;  4ELE A;  2W9H A;  6DFR A;  1RE7 A;  4KNE A;  4KAK A;  4FGH A;  3ROA A;  1DF7 A;  1DRH A;  3FRB X;  3UM8 A;  1U71 A;  2LF1 A;  4PSS A;  2INQ A;  1RA9 A;  3RO9 A;  1RX9 A;  3KGY A;  3I3R A;  1HFR A;  1BOZ A;  4HOE A;  5HI6 A;  3FRE X;  3NXR A;  1M79 A;  4Q67 A;  1AOE A;  1AO8 A;  1RX1 A;  2CIG A;  4IXG X;  2W3V A;  2AZN A;  1DIS A;  2G6V A;  2OIP A;  4DPH A;  4XRB A;  1DLS A;  3EEJ A;  3LG4 A;  3IRO A;  2DRC A;  3FRA X;  1JOM A;  3EX8 A;  4QI9 A;  1DR7 A;  3NXV A;  3NZB X;  1S3Y A;  3JW5 A;  3SRQ X;  4KD7 A;  1RB2 A;  3QYO A;  4LAH X;  5JA3 A;  4P3R A;  1TDR A;  1U72 A;  3FYW X;  4XT5 A;  2DHF A;  3UM6 A;  2HQP A;  3ZPG A;  1KLK A;  3SRR X;  3S3V A;  3GYF A;  3SA2 A;  1LY4 A;  1RA2 A;  2ANQ A;  2D5N A;  4M7U A;  4RGC A;  4DDR A;  4H97 A;  2XW7 A;  3CL9 A;  5DXV A;  3QFX A;  5HQY A;  4ELG A;  5HVB A;  3NZA X;  1RX4 A;  3NU0 A;  3M08 A;  4DP3 A;  1ZDR A;  1RH3 A;  1PD9 A;  4H96 A;  3TD8 A;  4I13 A;  3F0X X;  1AI9 A;  1DAJ A;  1DLR A;  4Q6A A;  3GHC A;  3SH2 A;  1IA4 A;  3UM5 A;  1RX3 A;  1J3J A;  3IX9 A;  1IA1 A;  3QLY A;  4KJJ A;  4EIZ A;  5HQZ A;  4X5J A;  4XT7 A;  2CD2 A;  4M2X A;  1RA8 A;  5EAJ A;  3NXT A;  3TQB A;  5ECX A;  1D1G A;  3QL0 A;  4NX6 A;  3OAF A;  3QLR A;  1RC4 A;  3GHV A;  4X5I A;  1RA1 A;  3K2H A;  3JWM A;  4Q0E A;  3TQA A;  3S9U A;  2BLA A;  3F8Y A;  3CD2 A;  4KEB A;  3K45 A;  4DFR A;  1DHF A;  1KMV A;  5JG0 X;  2ITH A;  4HOF A;  3QGT A;  4HA7 A;  3K47 A;  1RD7 A;  3DG8 A;  1RX2 A;  2FZH A;  4ECK A;  3NZ6 X;  3IRM A;  5DFR A;  2GD9 A;  3TQ8 A;  4QLG A;  3RG9 A;  3CSE A;  2B3Z A;  3EEK A;  3FQO A;  2W3W A;  1DYR A;  1KMS A;  4GH8 A;  1DYI A;  4G3M A;  1LUD A;  3DAT A;  3NXX A;  3FQC A;  4PST A;  1DG7 A;  1E26 A;  4M6L A;  1RX7 A;  3KJS A;  4G95 A;  3DGA A;  1OHK A;  4P3Q A;  4ELH A;  4PSY A;  3FYV X;  3FY9 X;  4QJZ D;  4ELB A;  3GHW A;  2W9S A;  5CCC A;  5HF2 X;  4I1N A;  4EJ1 A;  4KBN A;  3JW3 A;  3FY8 X;  5U26 A;  3FQZ A;  4QHV A;  4QLF A;  1DRB A;  1DDS A;  4KYA A;  1U70 A;  4XEC X;  4TU5 X;  4XT8 A;  3NXO A;  5HPB A;  3CLB A;  1RG7 A;  5FDA A;  3Q1H A;  1DRA A;  2ZZA A;  1DDR A;  2O7P A;  5HSU A;  1DG8 A;  1S3W A;  3QG2 A;  4KY8 A;  4DPD A;  1DR3 A;  1DRF A;  1DR5 A;  1RB3 A;  1DYJ A;  7DFR A;  3R33 A;  4LEK X;  4FGG A;  3JWK A;  4EIG A;  4NX7 A;  4IXF X;  1CZ3 A;  3IA4 A;  3ZPC A;  5HF0 X;  1DHI A;  4KM0 A;  3F8Z A;  3OCH A;  3NXY A;  4ELF A;  1DHJ A;  5CC9 A;  4QLE A;  4KJL A;  3IRN A;  3N0H A;  1IA3 A;  4H95 A;  3QLS A;  1QZF A;  5ECC A;  4QJC A;  3F91 A;  3DL6 A;  1RX8 A;  4KJK A;  4KL9 A;  2W9T A;  3JWF A;  3KFY A;  4P68 A;  5HT4 A;  1DG5 A;  4IXE D;  8DFR A;  3F0B X;  3DAU A;  3EEL A;  1DIU A;  3NZ9 X;  3SRW X;  1JUV A;  4XT4 A;  2ANO A;  3INV A;  2W3M A;  4M6J A;  3EEM A;  3GI2 A;  3VCO A;  4EIL A;  1VJ3 A;  3F0V X;  2BL9 A;  3JWC A;  3QLZ A;  3DRC A;  5HT5 A;  3SA1 A;  1VDR A;  2HXV A;  2W3B A;  1S3V A;  3M09 A;  4HA9 A;  1BZF A;  3KY8 A;  3NZC X;  4KY4 A;  3DL5 A;  2H2Q A;  4OSG A;  2BLC A;  1YHO A;  4PTH A;  3D80 A;  3NTZ A;  4X5F A;  1HFP A;  1DYH A;  1RX5 A;  3NZD A;  4XE6 X;  1PDB A;  1IA2 A;  3E0B A;  1DR1 A;  2KGK A;  4OR7 A;  4FHB A;  5E8Q A;  3HJ3 A;  3JTW A;  1JOL A;  3SRU X;  3IA5 A;  3F0S X;  2FZJ A;  1HFQ A;  1M7A A;  4CD2 A;  2P4G A;  1M78 A;  5U27 A;  2C2S A;  1RA3 A;  3F0Q X;  3FS6 A;  2HM9 A;  4PDJ A;  1MVT A;  1RX6 A;  1PD8 A;  3JVX A;  1DRE A;  3TQ9 A;  1OHJ A;  2L28 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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