4LAEX

Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
157
structure length
157
Chain Sequence
TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Staphylococcus aureus
molecule keywords Dihydrofolate reductase
total genus 43
structure length 157
sequence length 157
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-06-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4laeX00
1RG7A 1VJ3A 4XT4A 4ELBA 1DIUA 3QLSA 1HFPA 3IRMA 3VCOA 3NU0A 2D5NA 4H98A 4HOEA 4EIZA 3NZAX 1RF7A 1M78A 1E26A 1S3UA 3HJ3A 3NRRA 3S9UA 2JYBA 4ECKA 3R33A 3QLWA 3QL0A 3SAIA 2DHFA 4H97A 1KMSA 4ELEA 1IA1A 4DPDA 4XT5A 4XT6A 1PD9A 3IA4A 3SA2A 4QJZD 4EJ1A 1U70A 4DFRA 2W3BA 3QYOA 3CL9A 2ANOA 1PDBA 3FRBX 4XE6X 5JA3A 4KJKA 2FZHA 2W3VA 3FQFA 3FQCA 1CZ3A 1IA2A 7DFRA 3QL3A 4QI9A 4M6JA 2W3AA 4PTHA 1AOEA 4Q67A 1DAJA 4Q0DA 3NXTA 1DG8A 3RG9A 2BL9A 3M09A 1S3YA 5HI6A 1TDRA 1KLKA 2B3ZA 1BZFA 1DYJA 5FDAA 4QHVA 3EX8A 5U26A 2AZNA 1DREA 1VDRA 3DAUA 4Q6AA 2C2TA 3F0UX 4IXFX 3Q1HA 2W3MA 3K45A 4KM0A 4QJCA 3FY9X 3FL8A 1DYRA 1HFQA 3QLRA 1KMVA 1RX1A 5DXVA 5HQZA 1DRFA 4H95A 3TQ8A 3IRNA 3QYLA 4KJLA 3RO9A 3F8ZA 4I13A 3FS6A 4G95A 4XT7A 1MVSA 5HUIA 5ECCA 1RX2A 2G6VA 2GD9A 3FY8X 3IA5A 1U71A 4P68A 2BLAA 3SRQX 4KYAA 2OIPA 1SEJA 3JWCA 4PSYA 3FYVX 4Q0EA 3FRFX 1DDRA 2W9HA 3SH2A 4QLFA 1J3IA 4KNEA 1IA4A 5HT5A 3NXOA 3NXVA 3NZDA 4KM2A 3JVXA 3DG8A 3CD2A 3K47A 3UM5A 2INQA 3SRWX 3EEKA 5HF2X 1IA3A 4ELHA 3FYWX 2HM9A 3F0VX 4KLXA 4OSGA 4GH8A 1DG5A 1QZFA 3F0BX 2FZJA 3K74A 3SRUX 4XT8A 4KEBA 3DGAA 1RA8A 3I8AX 2W3WA 5HT4A 3F91A 3JWFA 3DFRA 4P3RA 3QG2A 2P4GA 1HFRA 3OCHA 4KY8A 3SGYA 1RX7A 3NZ9X 3S3VA 3DRCA 1LY3A 1S3WA 4DP3A 5HVBA 4TU5X 4KL9A 5HF0X 4LAEX 3ZPGA 3NZCX 1RA2A 4M2XA 1DLRA 1YHOA 1RE7A 5HSUA 1DF7A 1M7AA 4KJJA 4DPHA 3SRSX 5U27A 3IX9A 5JG0X 1OHJA 4XRBA 3TD8A 3JWMA 4P66A 5EAJA 3NZBX 1RC4A 4KFJA 4HA9A 4KD7A 3KFYA 3NZ6X 3NTZA 3D80A 3CLBA 3L3RA 3JSUA 2D0KA 3ROAA 3EEJA 4FGGA 1S3VA 3FRDX 5HQYA 2ANQA 2LF1A 1RB2A 3F0XX 2HXVA 3TQBA 4HOFA 3N0HA 1MVTA 1RX4A 2W9SA 1M79A 3KGYA 4X5JA 3SQYX 2XW7A 4CD2A 3GHWA 1DRHA 3NXXA 1DHIA 4G8ZX 3GI2A 3FQVA 3GHCA 1OHKA 2L28A 3KJRA 4DDRA 1BOZA 3GHVA 3I3RA 4HA7A 3QFXA 4H96A 4PTJA 1U72A 1DYIA 3LG4A 5HVEA 3QLYA 1DLSA 3F0QX 5E8QA 3SR5X 3DATA 4QLEA 1DISA 3NXYA 5ECXA 3FL9A 3DL6A 1CD2A 4FGHA 5HPBA 1LY4A 2C2SA 3E0BA 4G3MA 4RGCA 3UM6A 4ELFA 3JW5A 3EELA 3EEMA 5HSRA 4M6KA 3QLZA 2KGKA 1RA3A 4PDJA 4EIGA 2ITHA 3ZPCA 1DR5A 3FRAX 3SA1A 4M7UA 4KAKA 1RX5A 2HQPA 2ZZAA 5DFRA 5CCCA 3TQAA 3K2HA 4HOGA 4LAHX 2BLCA 2DRCA 2W9GA 3SRRX 1JUVA 4XECX 1DR3A 2H2QA 2FZIA 2W9TA 3QLXA 1RB3A 1JOLA 3DL5A 3GYFA 2CIGA 1RH3A 4EILA 3EIGA 5CC9A 3FQZA 3S7AA 3F0SX 4X5HA 4X5FA 4M7VA 1PD8A 1J3JA 3KJSA 1JOMA 3F8YA 4X5GA 4NX6A 3FQ0A 1LUDA 1RX8A 4KY4A 3JWKA 1RX3A 4IXED 1RX6A 3FREX 6DFRA 3JTWA 1D1GA 1J3KA 4OR7A 1DR6A 4KBNA 4FHBA 3IROA 1RA1A 1RX9A 4I1NA 4LEKX 8DFRA 1DDSA 3NXRA 1DYHA 4QLGA 1DR4A 4NX7A 2BLBA 1RA9A 1DRBA 2CD2A 1RD7A 4IXGX 3OAFA 3D84X 4PSSA 2O7PA 1DG7A 3UM8A 1ZDRA 4PSTA 3HBBA 4M6LA 4X5IA 1AO8A 3FQOA 1DHJA 1AI9A 2OBCA 2QK8A 3JW3A 4P3QA 4LAGX 3KY8A 3TQ9A 1DHFA 4ELGA 3QGTA 1DR1A 1DR2A 3CSEA 1DR7A 1DRAA 3INVA 3M08A
chains in the Genus database with same CATH superfamily
1RG7A 1VJ3A 4XT4A 4ELBA 1DIUA 3QLSA 1HFPA 3IRMA 3VCOA 3NU0A 2D5NA 4H98A 4HOEA 4EIZA 3NZAX 1RF7A 1M78A 1E26A 1S3UA 3HJ3A 3NRRA 3S9UA 2JYBA 4ECKA 3R33A 3QLWA 3QL0A 3SAIA 2DHFA 4H97A 1KMSA 4ELEA 1IA1A 4DPDA 4XT5A 4XT6A 1PD9A 3IA4A 3SA2A 4QJZD 4EJ1A 1U70A 4DFRA 2W3BA 3QYOA 3CL9A 2ANOA 1PDBA 3FRBX 4XE6X 5JA3A 4KJKA 2FZHA 2W3VA 3FQFA 3FQCA 1CZ3A 1IA2A 7DFRA 3QL3A 4QI9A 4M6JA 2W3AA 4PTHA 1AOEA 4Q67A 1DAJA 4Q0DA 3NXTA 1DG8A 3RG9A 2BL9A 3M09A 1S3YA 5HI6A 1TDRA 1KLKA 2B3ZA 1BZFA 1DYJA 5FDAA 4QHVA 3EX8A 5U26A 2AZNA 1DREA 1VDRA 3DAUA 4Q6AA 2C2TA 3F0UX 4IXFX 3Q1HA 2W3MA 3K45A 4KM0A 4QJCA 3FY9X 3FL8A 1DYRA 1HFQA 3QLRA 1KMVA 1RX1A 5DXVA 5HQZA 1DRFA 4H95A 3TQ8A 3IRNA 3QYLA 4KJLA 3RO9A 3F8ZA 4I13A 3FS6A 4G95A 4XT7A 1MVSA 5HUIA 5ECCA 1RX2A 2G6VA 2GD9A 3FY8X 3IA5A 1U71A 4P68A 2BLAA 3SRQX 4KYAA 2OIPA 1SEJA 3JWCA 4PSYA 3FYVX 4Q0EA 3FRFX 1DDRA 2W9HA 3SH2A 4QLFA 1J3IA 4KNEA 1IA4A 5HT5A 3NXOA 3NXVA 3NZDA 4KM2A 3JVXA 3DG8A 3CD2A 3K47A 3UM5A 2INQA 3SRWX 3EEKA 5HF2X 1IA3A 4ELHA 3FYWX 2HM9A 3F0VX 4KLXA 4OSGA 4GH8A 1DG5A 1QZFA 3F0BX 2FZJA 3K74A 3SRUX 4XT8A 4KEBA 3DGAA 1RA8A 3I8AX 2W3WA 5HT4A 3F91A 3JWFA 3DFRA 4P3RA 3QG2A 2P4GA 1HFRA 3OCHA 4KY8A 3SGYA 1RX7A 3NZ9X 3S3VA 3DRCA 1LY3A 1S3WA 4DP3A 5HVBA 4TU5X 4KL9A 5HF0X 4LAEX 3ZPGA 3NZCX 1RA2A 4M2XA 1DLRA 1YHOA 1RE7A 5HSUA 1DF7A 1M7AA 4KJJA 4DPHA 3SRSX 5U27A 3IX9A 5JG0X 1OHJA 4XRBA 3TD8A 3JWMA 4P66A 5EAJA 3NZBX 1RC4A 4KFJA 4HA9A 4KD7A 3KFYA 3NZ6X 3NTZA 3D80A 3CLBA 3L3RA 3JSUA 2D0KA 3ROAA 3EEJA 4FGGA 1S3VA 3FRDX 5HQYA 2ANQA 2LF1A 1RB2A 3F0XX 2HXVA 3TQBA 4HOFA 3N0HA 1MVTA 1RX4A 2W9SA 1M79A 3KGYA 4X5JA 3SQYX 2XW7A 4CD2A 3GHWA 1DRHA 3NXXA 1DHIA 4G8ZX 3GI2A 3FQVA 3GHCA 1OHKA 2L28A 3KJRA 4DDRA 1BOZA 3GHVA 3I3RA 4HA7A 3QFXA 4H96A 4PTJA 1U72A 1DYIA 3LG4A 5HVEA 3QLYA 1DLSA 3F0QX 5E8QA 3SR5X 3DATA 4QLEA 1DISA 3NXYA 5ECXA 3FL9A 3DL6A 1CD2A 4FGHA 5HPBA 1LY4A 2C2SA 3E0BA 4G3MA 4RGCA 3UM6A 4ELFA 3JW5A 3EELA 3EEMA 5HSRA 4M6KA 3QLZA 2KGKA 1RA3A 4PDJA 4EIGA 2ITHA 3ZPCA 1DR5A 3FRAX 3SA1A 4M7UA 4KAKA 1RX5A 2HQPA 2ZZAA 5DFRA 5CCCA 3TQAA 3K2HA 4HOGA 4LAHX 2BLCA 2DRCA 2W9GA 3SRRX 1JUVA 4XECX 1DR3A 2H2QA 2FZIA 2W9TA 3QLXA 1RB3A 1JOLA 3DL5A 3GYFA 2CIGA 1RH3A 4EILA 3EIGA 5CC9A 3FQZA 3S7AA 3F0SX 4X5HA 4X5FA 4M7VA 1PD8A 1J3JA 3KJSA 1JOMA 3F8YA 4X5GA 4NX6A 3FQ0A 1LUDA 1RX8A 4KY4A 3JWKA 1RX3A 4IXED 1RX6A 3FREX 6DFRA 3JTWA 1D1GA 1J3KA 4OR7A 1DR6A 4KBNA 4FHBA 3IROA 1RA1A 1RX9A 4I1NA 4LEKX 8DFRA 1DDSA 3NXRA 1DYHA 4QLGA 1DR4A 4NX7A 2BLBA 1RA9A 1DRBA 2CD2A 1RD7A 4IXGX 3OAFA 3D84X 4PSSA 2O7PA 1DG7A 3UM8A 1ZDRA 4PSTA 3HBBA 4M6LA 4X5IA 1AO8A 3FQOA 1DHJA 1AI9A 2OBCA 2QK8A 3JW3A 4P3QA 4LAGX 3KY8A 3TQ9A 1DHFA 4ELGA 3QGTA 1DR1A 1DR2A 3CSEA 1DR7A 1DRAA 3INVA 3M08A
chains in the Genus database with same CATH topology
1RG7A 1VJ3A 4XT4A 4ELBA 1DIUA 3QLSA 1HFPA 3IRMA 3VCOA 3NU0A 2D5NA 4H98A 4HOEA 4EIZA 3NZAX 1RF7A 1M78A 1E26A 1S3UA 3HJ3A 3NRRA 3S9UA 2JYBA 4ECKA 3R33A 3QLWA 3QL0A 3SAIA 2DHFA 4H97A 1KMSA 4ELEA 1IA1A 4DPDA 4XT5A 4XT6A 1PD9A 3IA4A 3SA2A 4QJZD 4EJ1A 1U70A 4DFRA 2W3BA 3QYOA 3CL9A 2ANOA 1PDBA 3FRBX 4XE6X 5JA3A 4KJKA 2FZHA 2W3VA 3FQFA 3FQCA 1CZ3A 1IA2A 7DFRA 3QL3A 4QI9A 4M6JA 2W3AA 4PTHA 1AOEA 4Q67A 1DAJA 4Q0DA 3NXTA 1DG8A 3RG9A 2BL9A 3M09A 1S3YA 5HI6A 1TDRA 1KLKA 2B3ZA 1BZFA 1DYJA 5FDAA 4QHVA 3EX8A 5U26A 2AZNA 1DREA 1VDRA 3DAUA 4Q6AA 2C2TA 3F0UX 4IXFX 3Q1HA 2W3MA 3K45A 4KM0A 4QJCA 3FY9X 3FL8A 1DYRA 1HFQA 3QLRA 1KMVA 1RX1A 5DXVA 5HQZA 1DRFA 4H95A 3TQ8A 3IRNA 3QYLA 4KJLA 3RO9A 3F8ZA 4I13A 3FS6A 4G95A 4XT7A 1MVSA 5HUIA 5ECCA 1RX2A 2G6VA 2GD9A 3FY8X 3IA5A 1U71A 4P68A 2BLAA 3SRQX 4KYAA 2OIPA 1SEJA 3JWCA 4PSYA 3FYVX 4Q0EA 3FRFX 1DDRA 2W9HA 3SH2A 4QLFA 1J3IA 4KNEA 1IA4A 5HT5A 3NXOA 3NXVA 3NZDA 4KM2A 3JVXA 3DG8A 3CD2A 3K47A 3UM5A 2INQA 3SRWX 3EEKA 5HF2X 1IA3A 4ELHA 3FYWX 2HM9A 3F0VX 4KLXA 4OSGA 4GH8A 1DG5A 1QZFA 3F0BX 2FZJA 3K74A 3SRUX 4XT8A 4KEBA 3DGAA 1RA8A 3I8AX 2W3WA 5HT4A 3F91A 3JWFA 3DFRA 4P3RA 3QG2A 2P4GA 1HFRA 3OCHA 4KY8A 3SGYA 1RX7A 3NZ9X 3S3VA 3DRCA 1LY3A 1S3WA 4DP3A 5HVBA 4TU5X 4KL9A 5HF0X 4LAEX 3ZPGA 3NZCX 1RA2A 4M2XA 1DLRA 1YHOA 1RE7A 5HSUA 1DF7A 1M7AA 4KJJA 4DPHA 3SRSX 5U27A 3IX9A 5JG0X 1OHJA 4XRBA 3TD8A 3JWMA 4P66A 5EAJA 3NZBX 1RC4A 4KFJA 4HA9A 4KD7A 3KFYA 3NZ6X 3NTZA 3D80A 3CLBA 3L3RA 3JSUA 2D0KA 3ROAA 3EEJA 4FGGA 1S3VA 3FRDX 5HQYA 2ANQA 2LF1A 1RB2A 3F0XX 2HXVA 3TQBA 4HOFA 3N0HA 1MVTA 1RX4A 2W9SA 1M79A 3KGYA 4X5JA 3SQYX 2XW7A 4CD2A 3GHWA 1DRHA 3NXXA 1DHIA 4G8ZX 3GI2A 3FQVA 3GHCA 1OHKA 2L28A 3KJRA 4DDRA 1BOZA 3GHVA 3I3RA 4HA7A 3QFXA 4H96A 4PTJA 1U72A 1DYIA 3LG4A 5HVEA 3QLYA 1DLSA 3F0QX 5E8QA 3SR5X 3DATA 4QLEA 1DISA 3NXYA 5ECXA 3FL9A 3DL6A 1CD2A 4FGHA 5HPBA 1LY4A 2C2SA 3E0BA 4G3MA 4RGCA 3UM6A 4ELFA 3JW5A 3EELA 3EEMA 5HSRA 4M6KA 3QLZA 2KGKA 1RA3A 4PDJA 4EIGA 2ITHA 3ZPCA 1DR5A 3FRAX 3SA1A 4M7UA 4KAKA 1RX5A 2HQPA 2ZZAA 5DFRA 5CCCA 3TQAA 3K2HA 4HOGA 4LAHX 2BLCA 2DRCA 2W9GA 3SRRX 1JUVA 4XECX 1DR3A 2H2QA 2FZIA 2W9TA 3QLXA 1RB3A 1JOLA 3DL5A 3GYFA 2CIGA 1RH3A 4EILA 3EIGA 5CC9A 3FQZA 3S7AA 3F0SX 4X5HA 4X5FA 4M7VA 1PD8A 1J3JA 3KJSA 1JOMA 3F8YA 4X5GA 4NX6A 3FQ0A 1LUDA 1RX8A 4KY4A 3JWKA 1RX3A 4IXED 1RX6A 3FREX 6DFRA 3JTWA 1D1GA 1J3KA 4OR7A 1DR6A 4KBNA 4FHBA 3IROA 1RA1A 1RX9A 4I1NA 4LEKX 8DFRA 1DDSA 3NXRA 1DYHA 4QLGA 1DR4A 4NX7A 2BLBA 1RA9A 1DRBA 2CD2A 1RD7A 4IXGX 3OAFA 3D84X 4PSSA 2O7PA 1DG7A 3UM8A 1ZDRA 4PSTA 3HBBA 4M6LA 4X5IA 1AO8A 3FQOA 1DHJA 1AI9A 2OBCA 2QK8A 3JW3A 4P3QA 4LAGX 3KY8A 3TQ9A 1DHFA 4ELGA 3QGTA 1DR1A 1DR2A 3CSEA 1DR7A 1DRAA 3INVA 3M08A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RG7 A;  1VJ3 A;  4XT4 A;  4ELB A;  1DIU A;  3QLS A;  1HFP A;  3IRM A;  3VCO A;  3NU0 A;  2D5N A;  4H98 A;  4HOE A;  4EIZ A;  3NZA X;  1RF7 A;  1M78 A;  1E26 A;  1S3U A;  3HJ3 A;  3NRR A;  3S9U A;  2JYB A;  4ECK A;  3R33 A;  3QLW A;  3QL0 A;  3SAI A;  2DHF A;  4H97 A;  1KMS A;  4ELE A;  1IA1 A;  4DPD A;  4XT5 A;  4XT6 A;  1PD9 A;  3IA4 A;  3SA2 A;  4QJZ D;  4EJ1 A;  1U70 A;  4DFR A;  2W3B A;  3QYO A;  3CL9 A;  2ANO A;  1PDB A;  3FRB X;  4XE6 X;  5JA3 A;  4KJK A;  2FZH A;  2W3V A;  3FQF A;  3FQC A;  1CZ3 A;  1IA2 A;  7DFR A;  3QL3 A;  4QI9 A;  4M6J A;  2W3A A;  4PTH A;  1AOE A;  4Q67 A;  1DAJ A;  4Q0D A;  3NXT A;  1DG8 A;  3RG9 A;  2BL9 A;  3M09 A;  1S3Y A;  5HI6 A;  1TDR A;  1KLK A;  2B3Z A;  1BZF A;  1DYJ A;  5FDA A;  4QHV A;  3EX8 A;  5U26 A;  2AZN A;  1DRE A;  1VDR A;  3DAU A;  4Q6A A;  2C2T A;  3F0U X;  4IXF X;  3Q1H A;  2W3M A;  3K45 A;  4KM0 A;  4QJC A;  3FY9 X;  3FL8 A;  1DYR A;  1HFQ A;  3QLR A;  1KMV A;  1RX1 A;  5DXV A;  5HQZ A;  1DRF A;  4H95 A;  3TQ8 A;  3IRN A;  3QYL A;  4KJL A;  3RO9 A;  3F8Z A;  4I13 A;  3FS6 A;  4G95 A;  4XT7 A;  1MVS A;  5HUI A;  5ECC A;  1RX2 A;  2G6V A;  2GD9 A;  3FY8 X;  3IA5 A;  1U71 A;  4P68 A;  2BLA A;  3SRQ X;  4KYA A;  2OIP A;  1SEJ A;  3JWC A;  4PSY A;  3FYV X;  4Q0E A;  3FRF X;  1DDR A;  2W9H A;  3SH2 A;  4QLF A;  1J3I A;  4KNE A;  1IA4 A;  5HT5 A;  3NXO A;  3NXV A;  3NZD A;  4KM2 A;  3JVX A;  3DG8 A;  3CD2 A;  3K47 A;  3UM5 A;  2INQ A;  3SRW X;  3EEK A;  5HF2 X;  1IA3 A;  4ELH A;  3FYW X;  2HM9 A;  3F0V X;  4KLX A;  4OSG A;  4GH8 A;  1DG5 A;  1QZF A;  3F0B X;  2FZJ A;  3K74 A;  3SRU X;  4XT8 A;  4KEB A;  3DGA A;  1RA8 A;  3I8A X;  2W3W A;  5HT4 A;  3F91 A;  3JWF A;  3DFR A;  4P3R A;  3QG2 A;  2P4G A;  1HFR A;  3OCH A;  4KY8 A;  3SGY A;  1RX7 A;  3NZ9 X;  3S3V A;  3DRC A;  1LY3 A;  1S3W A;  4DP3 A;  5HVB A;  4TU5 X;  4KL9 A;  5HF0 X;  4LAE X;  3ZPG A;  3NZC X;  1RA2 A;  4M2X A;  1DLR A;  1YHO A;  1RE7 A;  5HSU A;  1DF7 A;  1M7A A;  4KJJ A;  4DPH A;  3SRS X;  5U27 A;  3IX9 A;  5JG0 X;  1OHJ A;  4XRB A;  3TD8 A;  3JWM A;  4P66 A;  5EAJ A;  3NZB X;  1RC4 A;  4KFJ A;  4HA9 A;  4KD7 A;  3KFY A;  3NZ6 X;  3NTZ A;  3D80 A;  3CLB A;  3L3R A;  3JSU A;  2D0K A;  3ROA A;  3EEJ A;  4FGG A;  1S3V A;  3FRD X;  5HQY A;  2ANQ A;  2LF1 A;  1RB2 A;  3F0X X;  2HXV A;  3TQB A;  4HOF A;  3N0H A;  1MVT A;  1RX4 A;  2W9S A;  1M79 A;  3KGY A;  4X5J A;  3SQY X;  2XW7 A;  4CD2 A;  3GHW A;  1DRH A;  3NXX A;  1DHI A;  4G8Z X;  3GI2 A;  3FQV A;  3GHC A;  1OHK A;  2L28 A;  3KJR A;  4DDR A;  1BOZ A;  3GHV A;  3I3R A;  4HA7 A;  3QFX A;  4H96 A;  4PTJ A;  1U72 A;  1DYI A;  3LG4 A;  5HVE A;  3QLY A;  1DLS A;  3F0Q X;  5E8Q A;  3SR5 X;  3DAT A;  4QLE A;  1DIS A;  3NXY A;  5ECX A;  3FL9 A;  3DL6 A;  1CD2 A;  4FGH A;  5HPB A;  1LY4 A;  2C2S A;  3E0B A;  4G3M A;  4RGC A;  3UM6 A;  4ELF A;  3JW5 A;  3EEL A;  3EEM A;  5HSR A;  4M6K A;  3QLZ A;  2KGK A;  1RA3 A;  4PDJ A;  4EIG A;  2ITH A;  3ZPC A;  1DR5 A;  3FRA X;  3SA1 A;  4M7U A;  4KAK A;  1RX5 A;  2HQP A;  2ZZA A;  5DFR A;  5CCC A;  3TQA A;  3K2H A;  4HOG A;  4LAH X;  2BLC A;  2DRC A;  2W9G A;  3SRR X;  1JUV A;  4XEC X;  1DR3 A;  2H2Q A;  2FZI A;  2W9T A;  3QLX A;  1RB3 A;  1JOL A;  3DL5 A;  3GYF A;  2CIG A;  1RH3 A;  4EIL A;  3EIG A;  5CC9 A;  3FQZ A;  3S7A A;  3F0S X;  4X5H A;  4X5F A;  4M7V A;  1PD8 A;  1J3J A;  3KJS A;  1JOM A;  3F8Y A;  4X5G A;  4NX6 A;  3FQ0 A;  1LUD A;  1RX8 A;  4KY4 A;  3JWK A;  1RX3 A;  4IXE D;  1RX6 A;  3FRE X;  6DFR A;  3JTW A;  1D1G A;  1J3K A;  4OR7 A;  1DR6 A;  4KBN A;  4FHB A;  3IRO A;  1RA1 A;  1RX9 A;  4I1N A;  4LEK X;  8DFR A;  1DDS A;  3NXR A;  1DYH A;  4QLG A;  1DR4 A;  4NX7 A;  2BLB A;  1RA9 A;  1DRB A;  2CD2 A;  1RD7 A;  4IXG X;  3OAF A;  3D84 X;  4PSS A;  2O7P A;  1DG7 A;  3UM8 A;  1ZDR A;  4PST A;  3HBB A;  4M6L A;  4X5I A;  1AO8 A;  3FQO A;  1DHJ A;  1AI9 A;  2OBC A;  2QK8 A;  3JW3 A;  4P3Q A;  4LAG X;  3KY8 A;  3TQ9 A;  1DHF A;  4ELG A;  3QGT A;  1DR1 A;  1DR2 A;  3CSE A;  1DR7 A;  1DRA A;  3INV A;  3M08 A; 
#chains in the Genus database with same CATH topology
 1RG7 A;  1VJ3 A;  4XT4 A;  4ELB A;  1DIU A;  3QLS A;  1HFP A;  3IRM A;  3VCO A;  3NU0 A;  2D5N A;  4H98 A;  4HOE A;  4EIZ A;  3NZA X;  1RF7 A;  1M78 A;  1E26 A;  1S3U A;  3HJ3 A;  3NRR A;  3S9U A;  2JYB A;  4ECK A;  3R33 A;  3QLW A;  3QL0 A;  3SAI A;  2DHF A;  4H97 A;  1KMS A;  4ELE A;  1IA1 A;  4DPD A;  4XT5 A;  4XT6 A;  1PD9 A;  3IA4 A;  3SA2 A;  4QJZ D;  4EJ1 A;  1U70 A;  4DFR A;  2W3B A;  3QYO A;  3CL9 A;  2ANO A;  1PDB A;  3FRB X;  4XE6 X;  5JA3 A;  4KJK A;  2FZH A;  2W3V A;  3FQF A;  3FQC A;  1CZ3 A;  1IA2 A;  7DFR A;  3QL3 A;  4QI9 A;  4M6J A;  2W3A A;  4PTH A;  1AOE A;  4Q67 A;  1DAJ A;  4Q0D A;  3NXT A;  1DG8 A;  3RG9 A;  2BL9 A;  3M09 A;  1S3Y A;  5HI6 A;  1TDR A;  1KLK A;  2B3Z A;  1BZF A;  1DYJ A;  5FDA A;  4QHV A;  3EX8 A;  5U26 A;  2AZN A;  1DRE A;  1VDR A;  3DAU A;  4Q6A A;  2C2T A;  3F0U X;  4IXF X;  3Q1H A;  2W3M A;  3K45 A;  4KM0 A;  4QJC A;  3FY9 X;  3FL8 A;  1DYR A;  1HFQ A;  3QLR A;  1KMV A;  1RX1 A;  5DXV A;  5HQZ A;  1DRF A;  4H95 A;  3TQ8 A;  3IRN A;  3QYL A;  4KJL A;  3RO9 A;  3F8Z A;  4I13 A;  3FS6 A;  4G95 A;  4XT7 A;  1MVS A;  5HUI A;  5ECC A;  1RX2 A;  2G6V A;  2GD9 A;  3FY8 X;  3IA5 A;  1U71 A;  4P68 A;  2BLA A;  3SRQ X;  4KYA A;  2OIP A;  1SEJ A;  3JWC A;  4PSY A;  3FYV X;  4Q0E A;  3FRF X;  1DDR A;  2W9H A;  3SH2 A;  4QLF A;  1J3I A;  4KNE A;  1IA4 A;  5HT5 A;  3NXO A;  3NXV A;  3NZD A;  4KM2 A;  3JVX A;  3DG8 A;  3CD2 A;  3K47 A;  3UM5 A;  2INQ A;  3SRW X;  3EEK A;  5HF2 X;  1IA3 A;  4ELH A;  3FYW X;  2HM9 A;  3F0V X;  4KLX A;  4OSG A;  4GH8 A;  1DG5 A;  1QZF A;  3F0B X;  2FZJ A;  3K74 A;  3SRU X;  4XT8 A;  4KEB A;  3DGA A;  1RA8 A;  3I8A X;  2W3W A;  5HT4 A;  3F91 A;  3JWF A;  3DFR A;  4P3R A;  3QG2 A;  2P4G A;  1HFR A;  3OCH A;  4KY8 A;  3SGY A;  1RX7 A;  3NZ9 X;  3S3V A;  3DRC A;  1LY3 A;  1S3W A;  4DP3 A;  5HVB A;  4TU5 X;  4KL9 A;  5HF0 X;  4LAE X;  3ZPG A;  3NZC X;  1RA2 A;  4M2X A;  1DLR A;  1YHO A;  1RE7 A;  5HSU A;  1DF7 A;  1M7A A;  4KJJ A;  4DPH A;  3SRS X;  5U27 A;  3IX9 A;  5JG0 X;  1OHJ A;  4XRB A;  3TD8 A;  3JWM A;  4P66 A;  5EAJ A;  3NZB X;  1RC4 A;  4KFJ A;  4HA9 A;  4KD7 A;  3KFY A;  3NZ6 X;  3NTZ A;  3D80 A;  3CLB A;  3L3R A;  3JSU A;  2D0K A;  3ROA A;  3EEJ A;  4FGG A;  1S3V A;  3FRD X;  5HQY A;  2ANQ A;  2LF1 A;  1RB2 A;  3F0X X;  2HXV A;  3TQB A;  4HOF A;  3N0H A;  1MVT A;  1RX4 A;  2W9S A;  1M79 A;  3KGY A;  4X5J A;  3SQY X;  2XW7 A;  4CD2 A;  3GHW A;  1DRH A;  3NXX A;  1DHI A;  4G8Z X;  3GI2 A;  3FQV A;  3GHC A;  1OHK A;  2L28 A;  3KJR A;  4DDR A;  1BOZ A;  3GHV A;  3I3R A;  4HA7 A;  3QFX A;  4H96 A;  4PTJ A;  1U72 A;  1DYI A;  3LG4 A;  5HVE A;  3QLY A;  1DLS A;  3F0Q X;  5E8Q A;  3SR5 X;  3DAT A;  4QLE A;  1DIS A;  3NXY A;  5ECX A;  3FL9 A;  3DL6 A;  1CD2 A;  4FGH A;  5HPB A;  1LY4 A;  2C2S A;  3E0B A;  4G3M A;  4RGC A;  3UM6 A;  4ELF A;  3JW5 A;  3EEL A;  3EEM A;  5HSR A;  4M6K A;  3QLZ A;  2KGK A;  1RA3 A;  4PDJ A;  4EIG A;  2ITH A;  3ZPC A;  1DR5 A;  3FRA X;  3SA1 A;  4M7U A;  4KAK A;  1RX5 A;  2HQP A;  2ZZA A;  5DFR A;  5CCC A;  3TQA A;  3K2H A;  4HOG A;  4LAH X;  2BLC A;  2DRC A;  2W9G A;  3SRR X;  1JUV A;  4XEC X;  1DR3 A;  2H2Q A;  2FZI A;  2W9T A;  3QLX A;  1RB3 A;  1JOL A;  3DL5 A;  3GYF A;  2CIG A;  1RH3 A;  4EIL A;  3EIG A;  5CC9 A;  3FQZ A;  3S7A A;  3F0S X;  4X5H A;  4X5F A;  4M7V A;  1PD8 A;  1J3J A;  3KJS A;  1JOM A;  3F8Y A;  4X5G A;  4NX6 A;  3FQ0 A;  1LUD A;  1RX8 A;  4KY4 A;  3JWK A;  1RX3 A;  4IXE D;  1RX6 A;  3FRE X;  6DFR A;  3JTW A;  1D1G A;  1J3K A;  4OR7 A;  1DR6 A;  4KBN A;  4FHB A;  3IRO A;  1RA1 A;  1RX9 A;  4I1N A;  4LEK X;  8DFR A;  1DDS A;  3NXR A;  1DYH A;  4QLG A;  1DR4 A;  4NX7 A;  2BLB A;  1RA9 A;  1DRB A;  2CD2 A;  1RD7 A;  4IXG X;  3OAF A;  3D84 X;  4PSS A;  2O7P A;  1DG7 A;  3UM8 A;  1ZDR A;  4PST A;  3HBB A;  4M6L A;  4X5I A;  1AO8 A;  3FQO A;  1DHJ A;  1AI9 A;  2OBC A;  2QK8 A;  3JW3 A;  4P3Q A;  4LAG X;  3KY8 A;  3TQ9 A;  1DHF A;  4ELG A;  3QGT A;  1DR1 A;  1DR2 A;  3CSE A;  1DR7 A;  1DRA A;  3INV A;  3M08 A; 
#chains in the Genus database with same CATH homology
 1RG7 A;  1VJ3 A;  4XT4 A;  4ELB A;  1DIU A;  3QLS A;  1HFP A;  3IRM A;  3VCO A;  3NU0 A;  2D5N A;  4H98 A;  4HOE A;  4EIZ A;  3NZA X;  1RF7 A;  1M78 A;  1E26 A;  1S3U A;  3HJ3 A;  3NRR A;  3S9U A;  2JYB A;  4ECK A;  3R33 A;  3QLW A;  3QL0 A;  3SAI A;  2DHF A;  4H97 A;  1KMS A;  4ELE A;  1IA1 A;  4DPD A;  4XT5 A;  4XT6 A;  1PD9 A;  3IA4 A;  3SA2 A;  4QJZ D;  4EJ1 A;  1U70 A;  4DFR A;  2W3B A;  3QYO A;  3CL9 A;  2ANO A;  1PDB A;  3FRB X;  4XE6 X;  5JA3 A;  4KJK A;  2FZH A;  2W3V A;  3FQF A;  3FQC A;  1CZ3 A;  1IA2 A;  7DFR A;  3QL3 A;  4QI9 A;  4M6J A;  2W3A A;  4PTH A;  1AOE A;  4Q67 A;  1DAJ A;  4Q0D A;  3NXT A;  1DG8 A;  3RG9 A;  2BL9 A;  3M09 A;  1S3Y A;  5HI6 A;  1TDR A;  1KLK A;  2B3Z A;  1BZF A;  1DYJ A;  5FDA A;  4QHV A;  3EX8 A;  5U26 A;  2AZN A;  1DRE A;  1VDR A;  3DAU A;  4Q6A A;  2C2T A;  3F0U X;  4IXF X;  3Q1H A;  2W3M A;  3K45 A;  4KM0 A;  4QJC A;  3FY9 X;  3FL8 A;  1DYR A;  1HFQ A;  3QLR A;  1KMV A;  1RX1 A;  5DXV A;  5HQZ A;  1DRF A;  4H95 A;  3TQ8 A;  3IRN A;  3QYL A;  4KJL A;  3RO9 A;  3F8Z A;  4I13 A;  3FS6 A;  4G95 A;  4XT7 A;  1MVS A;  5HUI A;  5ECC A;  1RX2 A;  2G6V A;  2GD9 A;  3FY8 X;  3IA5 A;  1U71 A;  4P68 A;  2BLA A;  3SRQ X;  4KYA A;  2OIP A;  1SEJ A;  3JWC A;  4PSY A;  3FYV X;  4Q0E A;  3FRF X;  1DDR A;  2W9H A;  3SH2 A;  4QLF A;  1J3I A;  4KNE A;  1IA4 A;  5HT5 A;  3NXO A;  3NXV A;  3NZD A;  4KM2 A;  3JVX A;  3DG8 A;  3CD2 A;  3K47 A;  3UM5 A;  2INQ A;  3SRW X;  3EEK A;  5HF2 X;  1IA3 A;  4ELH A;  3FYW X;  2HM9 A;  3F0V X;  4KLX A;  4OSG A;  4GH8 A;  1DG5 A;  1QZF A;  3F0B X;  2FZJ A;  3K74 A;  3SRU X;  4XT8 A;  4KEB A;  3DGA A;  1RA8 A;  3I8A X;  2W3W A;  5HT4 A;  3F91 A;  3JWF A;  3DFR A;  4P3R A;  3QG2 A;  2P4G A;  1HFR A;  3OCH A;  4KY8 A;  3SGY A;  1RX7 A;  3NZ9 X;  3S3V A;  3DRC A;  1LY3 A;  1S3W A;  4DP3 A;  5HVB A;  4TU5 X;  4KL9 A;  5HF0 X;  4LAE X;  3ZPG A;  3NZC X;  1RA2 A;  4M2X A;  1DLR A;  1YHO A;  1RE7 A;  5HSU A;  1DF7 A;  1M7A A;  4KJJ A;  4DPH A;  3SRS X;  5U27 A;  3IX9 A;  5JG0 X;  1OHJ A;  4XRB A;  3TD8 A;  3JWM A;  4P66 A;  5EAJ A;  3NZB X;  1RC4 A;  4KFJ A;  4HA9 A;  4KD7 A;  3KFY A;  3NZ6 X;  3NTZ A;  3D80 A;  3CLB A;  3L3R A;  3JSU A;  2D0K A;  3ROA A;  3EEJ A;  4FGG A;  1S3V A;  3FRD X;  5HQY A;  2ANQ A;  2LF1 A;  1RB2 A;  3F0X X;  2HXV A;  3TQB A;  4HOF A;  3N0H A;  1MVT A;  1RX4 A;  2W9S A;  1M79 A;  3KGY A;  4X5J A;  3SQY X;  2XW7 A;  4CD2 A;  3GHW A;  1DRH A;  3NXX A;  1DHI A;  4G8Z X;  3GI2 A;  3FQV A;  3GHC A;  1OHK A;  2L28 A;  3KJR A;  4DDR A;  1BOZ A;  3GHV A;  3I3R A;  4HA7 A;  3QFX A;  4H96 A;  4PTJ A;  1U72 A;  1DYI A;  3LG4 A;  5HVE A;  3QLY A;  1DLS A;  3F0Q X;  5E8Q A;  3SR5 X;  3DAT A;  4QLE A;  1DIS A;  3NXY A;  5ECX A;  3FL9 A;  3DL6 A;  1CD2 A;  4FGH A;  5HPB A;  1LY4 A;  2C2S A;  3E0B A;  4G3M A;  4RGC A;  3UM6 A;  4ELF A;  3JW5 A;  3EEL A;  3EEM A;  5HSR A;  4M6K A;  3QLZ A;  2KGK A;  1RA3 A;  4PDJ A;  4EIG A;  2ITH A;  3ZPC A;  1DR5 A;  3FRA X;  3SA1 A;  4M7U A;  4KAK A;  1RX5 A;  2HQP A;  2ZZA A;  5DFR A;  5CCC A;  3TQA A;  3K2H A;  4HOG A;  4LAH X;  2BLC A;  2DRC A;  2W9G A;  3SRR X;  1JUV A;  4XEC X;  1DR3 A;  2H2Q A;  2FZI A;  2W9T A;  3QLX A;  1RB3 A;  1JOL A;  3DL5 A;  3GYF A;  2CIG A;  1RH3 A;  4EIL A;  3EIG A;  5CC9 A;  3FQZ A;  3S7A A;  3F0S X;  4X5H A;  4X5F A;  4M7V A;  1PD8 A;  1J3J A;  3KJS A;  1JOM A;  3F8Y A;  4X5G A;  4NX6 A;  3FQ0 A;  1LUD A;  1RX8 A;  4KY4 A;  3JWK A;  1RX3 A;  4IXE D;  1RX6 A;  3FRE X;  6DFR A;  3JTW A;  1D1G A;  1J3K A;  4OR7 A;  1DR6 A;  4KBN A;  4FHB A;  3IRO A;  1RA1 A;  1RX9 A;  4I1N A;  4LEK X;  8DFR A;  1DDS A;  3NXR A;  1DYH A;  4QLG A;  1DR4 A;  4NX7 A;  2BLB A;  1RA9 A;  1DRB A;  2CD2 A;  1RD7 A;  4IXG X;  3OAF A;  3D84 X;  4PSS A;  2O7P A;  1DG7 A;  3UM8 A;  1ZDR A;  4PST A;  3HBB A;  4M6L A;  4X5I A;  1AO8 A;  3FQO A;  1DHJ A;  1AI9 A;  2OBC A;  2QK8 A;  3JW3 A;  4P3Q A;  4LAG X;  3KY8 A;  3TQ9 A;  1DHF A;  4ELG A;  3QGT A;  1DR1 A;  1DR2 A;  3CSE A;  1DR7 A;  1DRA A;  3INV A;  3M08 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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