4LAHX

Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
157
structure length
157
Chain Sequence
TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Staphylococcus aureus
molecule keywords Dihydrofolate reductase
total genus 41
structure length 157
sequence length 157
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-06-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4lahX00
1KMSA 4XT8A 4IXFX 4FHBA 1TDRA 3SRWX 3QFXA 2ANQA 1U71A 5EAJA 4PSYA 4P3RA 5HF2X 1AOEA 3CL9A 1IA4A 3DL6A 3SGYA 1RC4A 4P3QA 1DRAA 1S3UA 3IA5A 4QLFA 4EILA 1CD2A 1OHKA 2L28A 2JYBA 1LY4A 1MVSA 3NU0A 2KGKA 2DRCA 4KD7A 3FL8A 1JUVA 4G8ZX 3JWFA 3NZCX 3IRNA 3RG9A 4XT7A 3QLSA 3CD2A 5HI6A 3QYOA 1J3IA 3FL9A 4LAEX 4PSSA 3DGAA 2W3AA 4KY4A 3I3RA 4PSTA 1LY3A 4QJZD 5HVEA 3IRMA 4ELFA 5HQYA 4H97A 1DYJA 3F0BX 3F0UX 1VJ3A 3FYVX 1QZFA 3F8YA 3M08A 3QLRA 2G6VA 3FY8X 3HJ3A 4XECX 3EEJA 3KY8A 2XW7A 4M7UA 5HT5A 3OCHA 1DHIA 2FZIA 1RA1A 4ELEA 1DG8A 4LAGX 3SAIA 4H96A 1IA2A 4LAHX 1VDRA 2W3WA 4M6JA 1ZDRA 3FRFX 3NXXA 1RG7A 1PD9A 4G3MA 3EEMA 3SA2A 1LUDA 1E26A 3E0BA 3SA1A 1U72A 3SH2A 2O7PA 4DPHA 2C2SA 4X5HA 5HQZA 3TD8A 4IXGX 3F0SX 5HSUA 4P66A 3SRSX 1DG5A 3FQ0A 4G95A 2ZZAA 1AO8A 4Q6AA 4KJLA 4QJCA 1JOMA 4X5GA 5CCCA 1J3JA 5DFRA 1DDRA 2CD2A 3UM5A 1S3WA 4KJKA 4XT5A 1RF7A 1RD7A 3N0HA 4KM0A 1DR4A 3QLYA 2LF1A 1RX5A 3SRQX 1RB3A 1HFRA 4LEKX 3DG8A 1M78A 1M79A 4DPDA 1DR5A 4X5FA 4QLGA 3DATA 1S3YA 1DR3A 1BOZA 3NXYA 1S3VA 1DISA 2BL9A 3EELA 3DRCA 4DDRA 3EIGA 1DLSA 1DDSA 3CSEA 4QLEA 3EX8A 1DAJA 4HA7A 4KAKA 1DR1A 1DRFA 4NX6A 1YHOA 4M6KA 4EIZA 4HOGA 4QHVA 1PD8A 3VCOA 1RX8A 3JWMA 1RX4A 3KJSA 4Q0DA 3HBBA 3FRBX 4OSGA 1RX2A 1U70A 2B3ZA 5DXVA 3Q1HA 2CIGA 1D1GA 2D0KA 3D84X 3DAUA 4KL9A 1DREA 4KYAA 4HOFA 3KJRA 1RX1A 5U27A 4KNEA 3K47A 1DF7A 3GI2A 1RA8A 3ZPCA 1RX9A 1DYHA 3NTZA 2OBCA 4KFJA 3SRUX 2BLCA 4HOEA 4CD2A 5HUIA 3GYFA 3QYLA 3QLWA 5HSRA 4H98A 3OAFA 3NXVA 5FDAA 4KJJA 4I13A 3IA4A 1DYRA 1RA2A 3NRRA 4KEBA 3FQOA 3M09A 8DFRA 3IX9A 4ECKA 3ZPGA 1DR2A 1RH3A 3GHWA 3JW3A 1SEJA 1DR7A 1RE7A 1DHJA 1IA1A 4Q67A 4XE6X 3RO9A 3FRDX 4OR7A 4FGGA 4XT4A 2P4GA 1DR6A 3ROAA 4M7VA 3FREX 3I8AX 3QL0A 4NX7A 4QI9A 6DFRA 1JOLA 2W3VA 4H95A 1AI9A 1DRHA 5U26A 4KLXA 3GHCA 3UM6A 3NZ6X 1RA9A 3CLBA 3K74A 3QLXA 3UM8A 3F0QX 2C2TA 3NZAX 1RX6A 2W9HA 1J3KA 3INVA 4M6LA 1RA3A 3TQ8A 2FZHA 1MVTA 3S7AA 3FQFA 3KGYA 3DL5A 3R33A 5CC9A 1RX3A 4M2XA 4KM2A 1RB2A 3QGTA 1IA3A 4KBNA 2BLAA 2FZJA 3SR5X 3NXTA 7DFRA 3F0VX 3NZDA 3S9UA 3F0XX 2DHFA 4XT6A 3IROA 2QK8A 3JWCA 1DHFA 3JTWA 4P68A 3FRAX 5ECXA 3F8ZA 2W9SA 5HPBA 3DFRA 4HA9A 1DLRA 3FQVA 3S3VA 3NZ9X 2W3BA 4ELHA 3D80A 3NXOA 4EIGA 2D5NA 2BLBA 1KMVA 2W3MA 5JG0X 3JWKA 2ANOA 3TQ9A 2OIPA 3F91A 3SQYX 3LG4A 4RGCA 3L3RA 4PTJA 1DIUA 1BZFA 4GH8A 1KLKA 2H2QA 3FYWX 4ELGA 5HF0X 4Q0EA 3FQCA 4PTHA 1OHJA 4KY8A 3K2HA 3FQZA 1DG7A 1DRBA 2HM9A 2ITHA 3JW5A 5ECCA 5HVBA 2GD9A 2HXVA 3QLZA 4PDJA 4X5JA 2W9TA 3FS6A 5HT4A 1HFQA 3FY9X 4TU5X 4XRBA 3NXRA 1RX7A 2AZNA 5E8QA 3GHVA 1HFPA 2HQPA 2W9GA 3EEKA 3JSUA 1PDBA 3JVXA 3KFYA 2INQA 3TQAA 4FGHA 3QG2A 3SRRX 4EJ1A 1DYIA 1CZ3A 3K45A 3NZBX 4X5IA 4I1NA 4DP3A 4ELBA 5JA3A 4IXED 3TQBA 3QL3A 1M7AA 4DFRA
chains in the Genus database with same CATH superfamily
1KMSA 4XT8A 4IXFX 4FHBA 1TDRA 3SRWX 3QFXA 2ANQA 1U71A 5EAJA 4PSYA 4P3RA 5HF2X 1AOEA 3CL9A 1IA4A 3DL6A 3SGYA 1RC4A 4P3QA 1DRAA 1S3UA 3IA5A 4QLFA 4EILA 1CD2A 1OHKA 2L28A 2JYBA 1LY4A 1MVSA 3NU0A 2KGKA 2DRCA 4KD7A 3FL8A 1JUVA 4G8ZX 3JWFA 3NZCX 3IRNA 3RG9A 4XT7A 3QLSA 3CD2A 5HI6A 3QYOA 1J3IA 3FL9A 4LAEX 4PSSA 3DGAA 2W3AA 4KY4A 3I3RA 4PSTA 1LY3A 4QJZD 5HVEA 3IRMA 4ELFA 5HQYA 4H97A 1DYJA 3F0BX 3F0UX 1VJ3A 3FYVX 1QZFA 3F8YA 3M08A 3QLRA 2G6VA 3FY8X 3HJ3A 4XECX 3EEJA 3KY8A 2XW7A 4M7UA 5HT5A 3OCHA 1DHIA 2FZIA 1RA1A 4ELEA 1DG8A 4LAGX 3SAIA 4H96A 1IA2A 4LAHX 1VDRA 2W3WA 4M6JA 1ZDRA 3FRFX 3NXXA 1RG7A 1PD9A 4G3MA 3EEMA 3SA2A 1LUDA 1E26A 3E0BA 3SA1A 1U72A 3SH2A 2O7PA 4DPHA 2C2SA 4X5HA 5HQZA 3TD8A 4IXGX 3F0SX 5HSUA 4P66A 3SRSX 1DG5A 3FQ0A 4G95A 2ZZAA 1AO8A 4Q6AA 4KJLA 4QJCA 1JOMA 4X5GA 5CCCA 1J3JA 5DFRA 1DDRA 2CD2A 3UM5A 1S3WA 4KJKA 4XT5A 1RF7A 1RD7A 3N0HA 4KM0A 1DR4A 3QLYA 2LF1A 1RX5A 3SRQX 1RB3A 1HFRA 4LEKX 3DG8A 1M78A 1M79A 4DPDA 1DR5A 4X5FA 4QLGA 3DATA 1S3YA 1DR3A 1BOZA 3NXYA 1S3VA 1DISA 2BL9A 3EELA 3DRCA 4DDRA 3EIGA 1DLSA 1DDSA 3CSEA 4QLEA 3EX8A 1DAJA 4HA7A 4KAKA 1DR1A 1DRFA 4NX6A 1YHOA 4M6KA 4EIZA 4HOGA 4QHVA 1PD8A 3VCOA 1RX8A 3JWMA 1RX4A 3KJSA 4Q0DA 3HBBA 3FRBX 4OSGA 1RX2A 1U70A 2B3ZA 5DXVA 3Q1HA 2CIGA 1D1GA 2D0KA 3D84X 3DAUA 4KL9A 1DREA 4KYAA 4HOFA 3KJRA 1RX1A 5U27A 4KNEA 3K47A 1DF7A 3GI2A 1RA8A 3ZPCA 1RX9A 1DYHA 3NTZA 2OBCA 4KFJA 3SRUX 2BLCA 4HOEA 4CD2A 5HUIA 3GYFA 3QYLA 3QLWA 5HSRA 4H98A 3OAFA 3NXVA 5FDAA 4KJJA 4I13A 3IA4A 1DYRA 1RA2A 3NRRA 4KEBA 3FQOA 3M09A 8DFRA 3IX9A 4ECKA 3ZPGA 1DR2A 1RH3A 3GHWA 3JW3A 1SEJA 1DR7A 1RE7A 1DHJA 1IA1A 4Q67A 4XE6X 3RO9A 3FRDX 4OR7A 4FGGA 4XT4A 2P4GA 1DR6A 3ROAA 4M7VA 3FREX 3I8AX 3QL0A 4NX7A 4QI9A 6DFRA 1JOLA 2W3VA 4H95A 1AI9A 1DRHA 5U26A 4KLXA 3GHCA 3UM6A 3NZ6X 1RA9A 3CLBA 3K74A 3QLXA 3UM8A 3F0QX 2C2TA 3NZAX 1RX6A 2W9HA 1J3KA 3INVA 4M6LA 1RA3A 3TQ8A 2FZHA 1MVTA 3S7AA 3FQFA 3KGYA 3DL5A 3R33A 5CC9A 1RX3A 4M2XA 4KM2A 1RB2A 3QGTA 1IA3A 4KBNA 2BLAA 2FZJA 3SR5X 3NXTA 7DFRA 3F0VX 3NZDA 3S9UA 3F0XX 2DHFA 4XT6A 3IROA 2QK8A 3JWCA 1DHFA 3JTWA 4P68A 3FRAX 5ECXA 3F8ZA 2W9SA 5HPBA 3DFRA 4HA9A 1DLRA 3FQVA 3S3VA 3NZ9X 2W3BA 4ELHA 3D80A 3NXOA 4EIGA 2D5NA 2BLBA 1KMVA 2W3MA 5JG0X 3JWKA 2ANOA 3TQ9A 2OIPA 3F91A 3SQYX 3LG4A 4RGCA 3L3RA 4PTJA 1DIUA 1BZFA 4GH8A 1KLKA 2H2QA 3FYWX 4ELGA 5HF0X 4Q0EA 3FQCA 4PTHA 1OHJA 4KY8A 3K2HA 3FQZA 1DG7A 1DRBA 2HM9A 2ITHA 3JW5A 5ECCA 5HVBA 2GD9A 2HXVA 3QLZA 4PDJA 4X5JA 2W9TA 3FS6A 5HT4A 1HFQA 3FY9X 4TU5X 4XRBA 3NXRA 1RX7A 2AZNA 5E8QA 3GHVA 1HFPA 2HQPA 2W9GA 3EEKA 3JSUA 1PDBA 3JVXA 3KFYA 2INQA 3TQAA 4FGHA 3QG2A 3SRRX 4EJ1A 1DYIA 1CZ3A 3K45A 3NZBX 4X5IA 4I1NA 4DP3A 4ELBA 5JA3A 4IXED 3TQBA 3QL3A 1M7AA 4DFRA
chains in the Genus database with same CATH topology
1KMSA 4XT8A 4IXFX 4FHBA 1TDRA 3SRWX 3QFXA 2ANQA 1U71A 5EAJA 4PSYA 4P3RA 5HF2X 1AOEA 3CL9A 1IA4A 3DL6A 3SGYA 1RC4A 4P3QA 1DRAA 1S3UA 3IA5A 4QLFA 4EILA 1CD2A 1OHKA 2L28A 2JYBA 1LY4A 1MVSA 3NU0A 2KGKA 2DRCA 4KD7A 3FL8A 1JUVA 4G8ZX 3JWFA 3NZCX 3IRNA 3RG9A 4XT7A 3QLSA 3CD2A 5HI6A 3QYOA 1J3IA 3FL9A 4LAEX 4PSSA 3DGAA 2W3AA 4KY4A 3I3RA 4PSTA 1LY3A 4QJZD 5HVEA 3IRMA 4ELFA 5HQYA 4H97A 1DYJA 3F0BX 3F0UX 1VJ3A 3FYVX 1QZFA 3F8YA 3M08A 3QLRA 2G6VA 3FY8X 3HJ3A 4XECX 3EEJA 3KY8A 2XW7A 4M7UA 5HT5A 3OCHA 1DHIA 2FZIA 1RA1A 4ELEA 1DG8A 4LAGX 3SAIA 4H96A 1IA2A 4LAHX 1VDRA 2W3WA 4M6JA 1ZDRA 3FRFX 3NXXA 1RG7A 1PD9A 4G3MA 3EEMA 3SA2A 1LUDA 1E26A 3E0BA 3SA1A 1U72A 3SH2A 2O7PA 4DPHA 2C2SA 4X5HA 5HQZA 3TD8A 4IXGX 3F0SX 5HSUA 4P66A 3SRSX 1DG5A 3FQ0A 4G95A 2ZZAA 1AO8A 4Q6AA 4KJLA 4QJCA 1JOMA 4X5GA 5CCCA 1J3JA 5DFRA 1DDRA 2CD2A 3UM5A 1S3WA 4KJKA 4XT5A 1RF7A 1RD7A 3N0HA 4KM0A 1DR4A 3QLYA 2LF1A 1RX5A 3SRQX 1RB3A 1HFRA 4LEKX 3DG8A 1M78A 1M79A 4DPDA 1DR5A 4X5FA 4QLGA 3DATA 1S3YA 1DR3A 1BOZA 3NXYA 1S3VA 1DISA 2BL9A 3EELA 3DRCA 4DDRA 3EIGA 1DLSA 1DDSA 3CSEA 4QLEA 3EX8A 1DAJA 4HA7A 4KAKA 1DR1A 1DRFA 4NX6A 1YHOA 4M6KA 4EIZA 4HOGA 4QHVA 1PD8A 3VCOA 1RX8A 3JWMA 1RX4A 3KJSA 4Q0DA 3HBBA 3FRBX 4OSGA 1RX2A 1U70A 2B3ZA 5DXVA 3Q1HA 2CIGA 1D1GA 2D0KA 3D84X 3DAUA 4KL9A 1DREA 4KYAA 4HOFA 3KJRA 1RX1A 5U27A 4KNEA 3K47A 1DF7A 3GI2A 1RA8A 3ZPCA 1RX9A 1DYHA 3NTZA 2OBCA 4KFJA 3SRUX 2BLCA 4HOEA 4CD2A 5HUIA 3GYFA 3QYLA 3QLWA 5HSRA 4H98A 3OAFA 3NXVA 5FDAA 4KJJA 4I13A 3IA4A 1DYRA 1RA2A 3NRRA 4KEBA 3FQOA 3M09A 8DFRA 3IX9A 4ECKA 3ZPGA 1DR2A 1RH3A 3GHWA 3JW3A 1SEJA 1DR7A 1RE7A 1DHJA 1IA1A 4Q67A 4XE6X 3RO9A 3FRDX 4OR7A 4FGGA 4XT4A 2P4GA 1DR6A 3ROAA 4M7VA 3FREX 3I8AX 3QL0A 4NX7A 4QI9A 6DFRA 1JOLA 2W3VA 4H95A 1AI9A 1DRHA 5U26A 4KLXA 3GHCA 3UM6A 3NZ6X 1RA9A 3CLBA 3K74A 3QLXA 3UM8A 3F0QX 2C2TA 3NZAX 1RX6A 2W9HA 1J3KA 3INVA 4M6LA 1RA3A 3TQ8A 2FZHA 1MVTA 3S7AA 3FQFA 3KGYA 3DL5A 3R33A 5CC9A 1RX3A 4M2XA 4KM2A 1RB2A 3QGTA 1IA3A 4KBNA 2BLAA 2FZJA 3SR5X 3NXTA 7DFRA 3F0VX 3NZDA 3S9UA 3F0XX 2DHFA 4XT6A 3IROA 2QK8A 3JWCA 1DHFA 3JTWA 4P68A 3FRAX 5ECXA 3F8ZA 2W9SA 5HPBA 3DFRA 4HA9A 1DLRA 3FQVA 3S3VA 3NZ9X 2W3BA 4ELHA 3D80A 3NXOA 4EIGA 2D5NA 2BLBA 1KMVA 2W3MA 5JG0X 3JWKA 2ANOA 3TQ9A 2OIPA 3F91A 3SQYX 3LG4A 4RGCA 3L3RA 4PTJA 1DIUA 1BZFA 4GH8A 1KLKA 2H2QA 3FYWX 4ELGA 5HF0X 4Q0EA 3FQCA 4PTHA 1OHJA 4KY8A 3K2HA 3FQZA 1DG7A 1DRBA 2HM9A 2ITHA 3JW5A 5ECCA 5HVBA 2GD9A 2HXVA 3QLZA 4PDJA 4X5JA 2W9TA 3FS6A 5HT4A 1HFQA 3FY9X 4TU5X 4XRBA 3NXRA 1RX7A 2AZNA 5E8QA 3GHVA 1HFPA 2HQPA 2W9GA 3EEKA 3JSUA 1PDBA 3JVXA 3KFYA 2INQA 3TQAA 4FGHA 3QG2A 3SRRX 4EJ1A 1DYIA 1CZ3A 3K45A 3NZBX 4X5IA 4I1NA 4DP3A 4ELBA 5JA3A 4IXED 3TQBA 3QL3A 1M7AA 4DFRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KMS A;  4XT8 A;  4IXF X;  4FHB A;  1TDR A;  3SRW X;  3QFX A;  2ANQ A;  1U71 A;  5EAJ A;  4PSY A;  4P3R A;  5HF2 X;  1AOE A;  3CL9 A;  1IA4 A;  3DL6 A;  3SGY A;  1RC4 A;  4P3Q A;  1DRA A;  1S3U A;  3IA5 A;  4QLF A;  4EIL A;  1CD2 A;  1OHK A;  2L28 A;  2JYB A;  1LY4 A;  1MVS A;  3NU0 A;  2KGK A;  2DRC A;  4KD7 A;  3FL8 A;  1JUV A;  4G8Z X;  3JWF A;  3NZC X;  3IRN A;  3RG9 A;  4XT7 A;  3QLS A;  3CD2 A;  5HI6 A;  3QYO A;  1J3I A;  3FL9 A;  4LAE X;  4PSS A;  3DGA A;  2W3A A;  4KY4 A;  3I3R A;  4PST A;  1LY3 A;  4QJZ D;  5HVE A;  3IRM A;  4ELF A;  5HQY A;  4H97 A;  1DYJ A;  3F0B X;  3F0U X;  1VJ3 A;  3FYV X;  1QZF A;  3F8Y A;  3M08 A;  3QLR A;  2G6V A;  3FY8 X;  3HJ3 A;  4XEC X;  3EEJ A;  3KY8 A;  2XW7 A;  4M7U A;  5HT5 A;  3OCH A;  1DHI A;  2FZI A;  1RA1 A;  4ELE A;  1DG8 A;  4LAG X;  3SAI A;  4H96 A;  1IA2 A;  4LAH X;  1VDR A;  2W3W A;  4M6J A;  1ZDR A;  3FRF X;  3NXX A;  1RG7 A;  1PD9 A;  4G3M A;  3EEM A;  3SA2 A;  1LUD A;  1E26 A;  3E0B A;  3SA1 A;  1U72 A;  3SH2 A;  2O7P A;  4DPH A;  2C2S A;  4X5H A;  5HQZ A;  3TD8 A;  4IXG X;  3F0S X;  5HSU A;  4P66 A;  3SRS X;  1DG5 A;  3FQ0 A;  4G95 A;  2ZZA A;  1AO8 A;  4Q6A A;  4KJL A;  4QJC A;  1JOM A;  4X5G A;  5CCC A;  1J3J A;  5DFR A;  1DDR A;  2CD2 A;  3UM5 A;  1S3W A;  4KJK A;  4XT5 A;  1RF7 A;  1RD7 A;  3N0H A;  4KM0 A;  1DR4 A;  3QLY A;  2LF1 A;  1RX5 A;  3SRQ X;  1RB3 A;  1HFR A;  4LEK X;  3DG8 A;  1M78 A;  1M79 A;  4DPD A;  1DR5 A;  4X5F A;  4QLG A;  3DAT A;  1S3Y A;  1DR3 A;  1BOZ A;  3NXY A;  1S3V A;  1DIS A;  2BL9 A;  3EEL A;  3DRC A;  4DDR A;  3EIG A;  1DLS A;  1DDS A;  3CSE A;  4QLE A;  3EX8 A;  1DAJ A;  4HA7 A;  4KAK A;  1DR1 A;  1DRF A;  4NX6 A;  1YHO A;  4M6K A;  4EIZ A;  4HOG A;  4QHV A;  1PD8 A;  3VCO A;  1RX8 A;  3JWM A;  1RX4 A;  3KJS A;  4Q0D A;  3HBB A;  3FRB X;  4OSG A;  1RX2 A;  1U70 A;  2B3Z A;  5DXV A;  3Q1H A;  2CIG A;  1D1G A;  2D0K A;  3D84 X;  3DAU A;  4KL9 A;  1DRE A;  4KYA A;  4HOF A;  3KJR A;  1RX1 A;  5U27 A;  4KNE A;  3K47 A;  1DF7 A;  3GI2 A;  1RA8 A;  3ZPC A;  1RX9 A;  1DYH A;  3NTZ A;  2OBC A;  4KFJ A;  3SRU X;  2BLC A;  4HOE A;  4CD2 A;  5HUI A;  3GYF A;  3QYL A;  3QLW A;  5HSR A;  4H98 A;  3OAF A;  3NXV A;  5FDA A;  4KJJ A;  4I13 A;  3IA4 A;  1DYR A;  1RA2 A;  3NRR A;  4KEB A;  3FQO A;  3M09 A;  8DFR A;  3IX9 A;  4ECK A;  3ZPG A;  1DR2 A;  1RH3 A;  3GHW A;  3JW3 A;  1SEJ A;  1DR7 A;  1RE7 A;  1DHJ A;  1IA1 A;  4Q67 A;  4XE6 X;  3RO9 A;  3FRD X;  4OR7 A;  4FGG A;  4XT4 A;  2P4G A;  1DR6 A;  3ROA A;  4M7V A;  3FRE X;  3I8A X;  3QL0 A;  4NX7 A;  4QI9 A;  6DFR A;  1JOL A;  2W3V A;  4H95 A;  1AI9 A;  1DRH A;  5U26 A;  4KLX A;  3GHC A;  3UM6 A;  3NZ6 X;  1RA9 A;  3CLB A;  3K74 A;  3QLX A;  3UM8 A;  3F0Q X;  2C2T A;  3NZA X;  1RX6 A;  2W9H A;  1J3K A;  3INV A;  4M6L A;  1RA3 A;  3TQ8 A;  2FZH A;  1MVT A;  3S7A A;  3FQF A;  3KGY A;  3DL5 A;  3R33 A;  5CC9 A;  1RX3 A;  4M2X A;  4KM2 A;  1RB2 A;  3QGT A;  1IA3 A;  4KBN A;  2BLA A;  2FZJ A;  3SR5 X;  3NXT A;  7DFR A;  3F0V X;  3NZD A;  3S9U A;  3F0X X;  2DHF A;  4XT6 A;  3IRO A;  2QK8 A;  3JWC A;  1DHF A;  3JTW A;  4P68 A;  3FRA X;  5ECX A;  3F8Z A;  2W9S A;  5HPB A;  3DFR A;  4HA9 A;  1DLR A;  3FQV A;  3S3V A;  3NZ9 X;  2W3B A;  4ELH A;  3D80 A;  3NXO A;  4EIG A;  2D5N A;  2BLB A;  1KMV A;  2W3M A;  5JG0 X;  3JWK A;  2ANO A;  3TQ9 A;  2OIP A;  3F91 A;  3SQY X;  3LG4 A;  4RGC A;  3L3R A;  4PTJ A;  1DIU A;  1BZF A;  4GH8 A;  1KLK A;  2H2Q A;  3FYW X;  4ELG A;  5HF0 X;  4Q0E A;  3FQC A;  4PTH A;  1OHJ A;  4KY8 A;  3K2H A;  3FQZ A;  1DG7 A;  1DRB A;  2HM9 A;  2ITH A;  3JW5 A;  5ECC A;  5HVB A;  2GD9 A;  2HXV A;  3QLZ A;  4PDJ A;  4X5J A;  2W9T A;  3FS6 A;  5HT4 A;  1HFQ A;  3FY9 X;  4TU5 X;  4XRB A;  3NXR A;  1RX7 A;  2AZN A;  5E8Q A;  3GHV A;  1HFP A;  2HQP A;  2W9G A;  3EEK A;  3JSU A;  1PDB A;  3JVX A;  3KFY A;  2INQ A;  3TQA A;  4FGH A;  3QG2 A;  3SRR X;  4EJ1 A;  1DYI A;  1CZ3 A;  3K45 A;  3NZB X;  4X5I A;  4I1N A;  4DP3 A;  4ELB A;  5JA3 A;  4IXE D;  3TQB A;  3QL3 A;  1M7A A;  4DFR A; 
#chains in the Genus database with same CATH topology
 1KMS A;  4XT8 A;  4IXF X;  4FHB A;  1TDR A;  3SRW X;  3QFX A;  2ANQ A;  1U71 A;  5EAJ A;  4PSY A;  4P3R A;  5HF2 X;  1AOE A;  3CL9 A;  1IA4 A;  3DL6 A;  3SGY A;  1RC4 A;  4P3Q A;  1DRA A;  1S3U A;  3IA5 A;  4QLF A;  4EIL A;  1CD2 A;  1OHK A;  2L28 A;  2JYB A;  1LY4 A;  1MVS A;  3NU0 A;  2KGK A;  2DRC A;  4KD7 A;  3FL8 A;  1JUV A;  4G8Z X;  3JWF A;  3NZC X;  3IRN A;  3RG9 A;  4XT7 A;  3QLS A;  3CD2 A;  5HI6 A;  3QYO A;  1J3I A;  3FL9 A;  4LAE X;  4PSS A;  3DGA A;  2W3A A;  4KY4 A;  3I3R A;  4PST A;  1LY3 A;  4QJZ D;  5HVE A;  3IRM A;  4ELF A;  5HQY A;  4H97 A;  1DYJ A;  3F0B X;  3F0U X;  1VJ3 A;  3FYV X;  1QZF A;  3F8Y A;  3M08 A;  3QLR A;  2G6V A;  3FY8 X;  3HJ3 A;  4XEC X;  3EEJ A;  3KY8 A;  2XW7 A;  4M7U A;  5HT5 A;  3OCH A;  1DHI A;  2FZI A;  1RA1 A;  4ELE A;  1DG8 A;  4LAG X;  3SAI A;  4H96 A;  1IA2 A;  4LAH X;  1VDR A;  2W3W A;  4M6J A;  1ZDR A;  3FRF X;  3NXX A;  1RG7 A;  1PD9 A;  4G3M A;  3EEM A;  3SA2 A;  1LUD A;  1E26 A;  3E0B A;  3SA1 A;  1U72 A;  3SH2 A;  2O7P A;  4DPH A;  2C2S A;  4X5H A;  5HQZ A;  3TD8 A;  4IXG X;  3F0S X;  5HSU A;  4P66 A;  3SRS X;  1DG5 A;  3FQ0 A;  4G95 A;  2ZZA A;  1AO8 A;  4Q6A A;  4KJL A;  4QJC A;  1JOM A;  4X5G A;  5CCC A;  1J3J A;  5DFR A;  1DDR A;  2CD2 A;  3UM5 A;  1S3W A;  4KJK A;  4XT5 A;  1RF7 A;  1RD7 A;  3N0H A;  4KM0 A;  1DR4 A;  3QLY A;  2LF1 A;  1RX5 A;  3SRQ X;  1RB3 A;  1HFR A;  4LEK X;  3DG8 A;  1M78 A;  1M79 A;  4DPD A;  1DR5 A;  4X5F A;  4QLG A;  3DAT A;  1S3Y A;  1DR3 A;  1BOZ A;  3NXY A;  1S3V A;  1DIS A;  2BL9 A;  3EEL A;  3DRC A;  4DDR A;  3EIG A;  1DLS A;  1DDS A;  3CSE A;  4QLE A;  3EX8 A;  1DAJ A;  4HA7 A;  4KAK A;  1DR1 A;  1DRF A;  4NX6 A;  1YHO A;  4M6K A;  4EIZ A;  4HOG A;  4QHV A;  1PD8 A;  3VCO A;  1RX8 A;  3JWM A;  1RX4 A;  3KJS A;  4Q0D A;  3HBB A;  3FRB X;  4OSG A;  1RX2 A;  1U70 A;  2B3Z A;  5DXV A;  3Q1H A;  2CIG A;  1D1G A;  2D0K A;  3D84 X;  3DAU A;  4KL9 A;  1DRE A;  4KYA A;  4HOF A;  3KJR A;  1RX1 A;  5U27 A;  4KNE A;  3K47 A;  1DF7 A;  3GI2 A;  1RA8 A;  3ZPC A;  1RX9 A;  1DYH A;  3NTZ A;  2OBC A;  4KFJ A;  3SRU X;  2BLC A;  4HOE A;  4CD2 A;  5HUI A;  3GYF A;  3QYL A;  3QLW A;  5HSR A;  4H98 A;  3OAF A;  3NXV A;  5FDA A;  4KJJ A;  4I13 A;  3IA4 A;  1DYR A;  1RA2 A;  3NRR A;  4KEB A;  3FQO A;  3M09 A;  8DFR A;  3IX9 A;  4ECK A;  3ZPG A;  1DR2 A;  1RH3 A;  3GHW A;  3JW3 A;  1SEJ A;  1DR7 A;  1RE7 A;  1DHJ A;  1IA1 A;  4Q67 A;  4XE6 X;  3RO9 A;  3FRD X;  4OR7 A;  4FGG A;  4XT4 A;  2P4G A;  1DR6 A;  3ROA A;  4M7V A;  3FRE X;  3I8A X;  3QL0 A;  4NX7 A;  4QI9 A;  6DFR A;  1JOL A;  2W3V A;  4H95 A;  1AI9 A;  1DRH A;  5U26 A;  4KLX A;  3GHC A;  3UM6 A;  3NZ6 X;  1RA9 A;  3CLB A;  3K74 A;  3QLX A;  3UM8 A;  3F0Q X;  2C2T A;  3NZA X;  1RX6 A;  2W9H A;  1J3K A;  3INV A;  4M6L A;  1RA3 A;  3TQ8 A;  2FZH A;  1MVT A;  3S7A A;  3FQF A;  3KGY A;  3DL5 A;  3R33 A;  5CC9 A;  1RX3 A;  4M2X A;  4KM2 A;  1RB2 A;  3QGT A;  1IA3 A;  4KBN A;  2BLA A;  2FZJ A;  3SR5 X;  3NXT A;  7DFR A;  3F0V X;  3NZD A;  3S9U A;  3F0X X;  2DHF A;  4XT6 A;  3IRO A;  2QK8 A;  3JWC A;  1DHF A;  3JTW A;  4P68 A;  3FRA X;  5ECX A;  3F8Z A;  2W9S A;  5HPB A;  3DFR A;  4HA9 A;  1DLR A;  3FQV A;  3S3V A;  3NZ9 X;  2W3B A;  4ELH A;  3D80 A;  3NXO A;  4EIG A;  2D5N A;  2BLB A;  1KMV A;  2W3M A;  5JG0 X;  3JWK A;  2ANO A;  3TQ9 A;  2OIP A;  3F91 A;  3SQY X;  3LG4 A;  4RGC A;  3L3R A;  4PTJ A;  1DIU A;  1BZF A;  4GH8 A;  1KLK A;  2H2Q A;  3FYW X;  4ELG A;  5HF0 X;  4Q0E A;  3FQC A;  4PTH A;  1OHJ A;  4KY8 A;  3K2H A;  3FQZ A;  1DG7 A;  1DRB A;  2HM9 A;  2ITH A;  3JW5 A;  5ECC A;  5HVB A;  2GD9 A;  2HXV A;  3QLZ A;  4PDJ A;  4X5J A;  2W9T A;  3FS6 A;  5HT4 A;  1HFQ A;  3FY9 X;  4TU5 X;  4XRB A;  3NXR A;  1RX7 A;  2AZN A;  5E8Q A;  3GHV A;  1HFP A;  2HQP A;  2W9G A;  3EEK A;  3JSU A;  1PDB A;  3JVX A;  3KFY A;  2INQ A;  3TQA A;  4FGH A;  3QG2 A;  3SRR X;  4EJ1 A;  1DYI A;  1CZ3 A;  3K45 A;  3NZB X;  4X5I A;  4I1N A;  4DP3 A;  4ELB A;  5JA3 A;  4IXE D;  3TQB A;  3QL3 A;  1M7A A;  4DFR A; 
#chains in the Genus database with same CATH homology
 1KMS A;  4XT8 A;  4IXF X;  4FHB A;  1TDR A;  3SRW X;  3QFX A;  2ANQ A;  1U71 A;  5EAJ A;  4PSY A;  4P3R A;  5HF2 X;  1AOE A;  3CL9 A;  1IA4 A;  3DL6 A;  3SGY A;  1RC4 A;  4P3Q A;  1DRA A;  1S3U A;  3IA5 A;  4QLF A;  4EIL A;  1CD2 A;  1OHK A;  2L28 A;  2JYB A;  1LY4 A;  1MVS A;  3NU0 A;  2KGK A;  2DRC A;  4KD7 A;  3FL8 A;  1JUV A;  4G8Z X;  3JWF A;  3NZC X;  3IRN A;  3RG9 A;  4XT7 A;  3QLS A;  3CD2 A;  5HI6 A;  3QYO A;  1J3I A;  3FL9 A;  4LAE X;  4PSS A;  3DGA A;  2W3A A;  4KY4 A;  3I3R A;  4PST A;  1LY3 A;  4QJZ D;  5HVE A;  3IRM A;  4ELF A;  5HQY A;  4H97 A;  1DYJ A;  3F0B X;  3F0U X;  1VJ3 A;  3FYV X;  1QZF A;  3F8Y A;  3M08 A;  3QLR A;  2G6V A;  3FY8 X;  3HJ3 A;  4XEC X;  3EEJ A;  3KY8 A;  2XW7 A;  4M7U A;  5HT5 A;  3OCH A;  1DHI A;  2FZI A;  1RA1 A;  4ELE A;  1DG8 A;  4LAG X;  3SAI A;  4H96 A;  1IA2 A;  4LAH X;  1VDR A;  2W3W A;  4M6J A;  1ZDR A;  3FRF X;  3NXX A;  1RG7 A;  1PD9 A;  4G3M A;  3EEM A;  3SA2 A;  1LUD A;  1E26 A;  3E0B A;  3SA1 A;  1U72 A;  3SH2 A;  2O7P A;  4DPH A;  2C2S A;  4X5H A;  5HQZ A;  3TD8 A;  4IXG X;  3F0S X;  5HSU A;  4P66 A;  3SRS X;  1DG5 A;  3FQ0 A;  4G95 A;  2ZZA A;  1AO8 A;  4Q6A A;  4KJL A;  4QJC A;  1JOM A;  4X5G A;  5CCC A;  1J3J A;  5DFR A;  1DDR A;  2CD2 A;  3UM5 A;  1S3W A;  4KJK A;  4XT5 A;  1RF7 A;  1RD7 A;  3N0H A;  4KM0 A;  1DR4 A;  3QLY A;  2LF1 A;  1RX5 A;  3SRQ X;  1RB3 A;  1HFR A;  4LEK X;  3DG8 A;  1M78 A;  1M79 A;  4DPD A;  1DR5 A;  4X5F A;  4QLG A;  3DAT A;  1S3Y A;  1DR3 A;  1BOZ A;  3NXY A;  1S3V A;  1DIS A;  2BL9 A;  3EEL A;  3DRC A;  4DDR A;  3EIG A;  1DLS A;  1DDS A;  3CSE A;  4QLE A;  3EX8 A;  1DAJ A;  4HA7 A;  4KAK A;  1DR1 A;  1DRF A;  4NX6 A;  1YHO A;  4M6K A;  4EIZ A;  4HOG A;  4QHV A;  1PD8 A;  3VCO A;  1RX8 A;  3JWM A;  1RX4 A;  3KJS A;  4Q0D A;  3HBB A;  3FRB X;  4OSG A;  1RX2 A;  1U70 A;  2B3Z A;  5DXV A;  3Q1H A;  2CIG A;  1D1G A;  2D0K A;  3D84 X;  3DAU A;  4KL9 A;  1DRE A;  4KYA A;  4HOF A;  3KJR A;  1RX1 A;  5U27 A;  4KNE A;  3K47 A;  1DF7 A;  3GI2 A;  1RA8 A;  3ZPC A;  1RX9 A;  1DYH A;  3NTZ A;  2OBC A;  4KFJ A;  3SRU X;  2BLC A;  4HOE A;  4CD2 A;  5HUI A;  3GYF A;  3QYL A;  3QLW A;  5HSR A;  4H98 A;  3OAF A;  3NXV A;  5FDA A;  4KJJ A;  4I13 A;  3IA4 A;  1DYR A;  1RA2 A;  3NRR A;  4KEB A;  3FQO A;  3M09 A;  8DFR A;  3IX9 A;  4ECK A;  3ZPG A;  1DR2 A;  1RH3 A;  3GHW A;  3JW3 A;  1SEJ A;  1DR7 A;  1RE7 A;  1DHJ A;  1IA1 A;  4Q67 A;  4XE6 X;  3RO9 A;  3FRD X;  4OR7 A;  4FGG A;  4XT4 A;  2P4G A;  1DR6 A;  3ROA A;  4M7V A;  3FRE X;  3I8A X;  3QL0 A;  4NX7 A;  4QI9 A;  6DFR A;  1JOL A;  2W3V A;  4H95 A;  1AI9 A;  1DRH A;  5U26 A;  4KLX A;  3GHC A;  3UM6 A;  3NZ6 X;  1RA9 A;  3CLB A;  3K74 A;  3QLX A;  3UM8 A;  3F0Q X;  2C2T A;  3NZA X;  1RX6 A;  2W9H A;  1J3K A;  3INV A;  4M6L A;  1RA3 A;  3TQ8 A;  2FZH A;  1MVT A;  3S7A A;  3FQF A;  3KGY A;  3DL5 A;  3R33 A;  5CC9 A;  1RX3 A;  4M2X A;  4KM2 A;  1RB2 A;  3QGT A;  1IA3 A;  4KBN A;  2BLA A;  2FZJ A;  3SR5 X;  3NXT A;  7DFR A;  3F0V X;  3NZD A;  3S9U A;  3F0X X;  2DHF A;  4XT6 A;  3IRO A;  2QK8 A;  3JWC A;  1DHF A;  3JTW A;  4P68 A;  3FRA X;  5ECX A;  3F8Z A;  2W9S A;  5HPB A;  3DFR A;  4HA9 A;  1DLR A;  3FQV A;  3S3V A;  3NZ9 X;  2W3B A;  4ELH A;  3D80 A;  3NXO A;  4EIG A;  2D5N A;  2BLB A;  1KMV A;  2W3M A;  5JG0 X;  3JWK A;  2ANO A;  3TQ9 A;  2OIP A;  3F91 A;  3SQY X;  3LG4 A;  4RGC A;  3L3R A;  4PTJ A;  1DIU A;  1BZF A;  4GH8 A;  1KLK A;  2H2Q A;  3FYW X;  4ELG A;  5HF0 X;  4Q0E A;  3FQC A;  4PTH A;  1OHJ A;  4KY8 A;  3K2H A;  3FQZ A;  1DG7 A;  1DRB A;  2HM9 A;  2ITH A;  3JW5 A;  5ECC A;  5HVB A;  2GD9 A;  2HXV A;  3QLZ A;  4PDJ A;  4X5J A;  2W9T A;  3FS6 A;  5HT4 A;  1HFQ A;  3FY9 X;  4TU5 X;  4XRB A;  3NXR A;  1RX7 A;  2AZN A;  5E8Q A;  3GHV A;  1HFP A;  2HQP A;  2W9G A;  3EEK A;  3JSU A;  1PDB A;  3JVX A;  3KFY A;  2INQ A;  3TQA A;  4FGH A;  3QG2 A;  3SRR X;  4EJ1 A;  1DYI A;  1CZ3 A;  3K45 A;  3NZB X;  4X5I A;  4I1N A;  4DP3 A;  4ELB A;  5JA3 A;  4IXE D;  3TQB A;  3QL3 A;  1M7A A;  4DFR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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