4M2XA

Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (tmq)
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
159
structure length
159
Chain Sequence
MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective inhibitors for dihydrofolate reductase from mycobacterium tuberculosis
rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Mycobacterium tuberculosis
molecule keywords Dihydrofolate reductase
total genus 42
structure length 159
sequence length 159
chains with identical sequence C, E, G
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-08-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4m2xA00
3E0BA 3ZPGA 3NRRA 1JOMA 1DG8A 3SRSX 3D84X 2L28A 1VJ3A 4QJZD 1DR6A 3QG2A 3JWCA 4LEKX 3K45A 7DFRA 4H97A 3QFXA 4CD2A 2BL9A 3IRNA 2G6VA 5ECXA 5DFRA 1U71A 4EIZA 3QLRA 5U26A 4KAKA 3S9UA 3FQOA 1LY3A 4QLEA 1D1GA 1E26A 3UM8A 4HOFA 5HT5A 2BLCA 3M09A 3FQ0A 3Q1HA 4OSGA 3FYVX 1IA4A 3OCHA 3M08A 4PSTA 1DHFA 3FY9X 3QLXA 3NZ6X 2INQA 4M2XA 4M6KA 1DR1A 2W3MA 3INVA 3NTZA 6DFRA 1PDBA 1RH3A 3QLWA 2BLAA 3KJSA 4TU5X 3FRAX 5U27A 1S3UA 5HQZA 1RB3A 4QHVA 4LAHX 3VCOA 3UM5A 3NXOA 2FZHA 4X5FA 1YHOA 1U72A 3HBBA 4LAEX 2JYBA 3SGYA 4ECKA 1DR7A 5HUIA 1DREA 4P68A 3UM6A 3JTWA 4XECX 2HXVA 3IA4A 1DRAA 4G3MA 3F0VX 4HOGA 2ITHA 3TQBA 3GHWA 3KGYA 3FY8X 4RGCA 3FQCA 3ZPCA 1AI9A 3F0XX 2W9SA 2ANOA 1DYJA 1RX4A 3NXXA 4IXFX 3NXVA 3QGTA 1RF7A 3IA5A 3NZBX 4P3RA 3IROA 1RX8A 4X5GA 1RX7A 4KNEA 3FL9A 3NU0A 3JWKA 5JG0X 3F0BX 5HSRA 1S3YA 1DF7A 3SRRX 1J3KA 1OHJA 5DXVA 4Q67A 3F0UX 2W3BA 3EELA 2HM9A 4FHBA 3L3RA 1IA3A 4IXED 3SQYX 1DISA 3QLSA 3FS6A 4EIGA 3JW5A 1DR5A 3K2HA 5HI6A 3FQZA 4XRBA 3FYWX 4PTJA 1VDRA 3KJRA 1HFRA 3F0SX 1RA8A 3QL3A 2W9HA 5CC9A 2W9TA 4QLGA 4PSYA 1HFQA 1S3VA 1HFPA 3DGAA 5HF2X 3QYLA 1DLRA 1OHKA 1JUVA 4KJLA 4Q6AA 4PTHA 3DFRA 8DFRA 4NX7A 1CD2A 4X5IA 1J3IA 1RA3A 3SRWX 3EEMA 4M7UA 1IA1A 1RB2A 3KY8A 2O7PA 3NZ9X 4ELGA 3SRUX 1DR2A 1DRFA 4XE6X 2GD9A 3ROAA 4KM2A 1DHJA 3I8AX 3NXRA 4G95A 4KY4A 1MVSA 2AZNA 4KLXA 3FQFA 1RE7A 3CSEA 2D0KA 2CIGA 3SR5X 3K47A 1DYHA 1LY4A 2FZIA 1M78A 1IA2A 2W3VA 4HA9A 5HSUA 4KYAA 4G8ZX 4KJJA 3TD8A 3DAUA 3JSUA 4ELHA 2QK8A 1KLKA 3EX8A 4DPHA 2FZJA 3FL8A 3CD2A 4DFRA 1DR4A 4HOEA 4P3QA 3QLYA 3SRQX 3K74A 5HVBA 1DAJA 3DRCA 3DG8A 1DIUA 5HT4A 4LAGX 2B3ZA 2W3AA 3N0HA 3GHVA 3EIGA 4X5HA 3JWFA 1RX1A 1DRHA 3QYOA 4P66A 1AOEA 1PD9A 1S3WA 3GHCA 2OIPA 5CCCA 3NZCX 4KD7A 4XT4A 3F8YA 2BLBA 4Q0EA 1M79A 2DRCA 3F91A 5FDAA 4XT8A 4M6JA 3TQAA 3FRBX 1DHIA 4QJCA 2C2TA 4I13A 4FGHA 3CL9A 1DDRA 4QLFA 1BZFA 4XT5A 4KEBA 3NZDA 4H96A 3R33A 2DHFA 4KL9A 4X5JA 2W9GA 3QLZA 4DDRA 1RX5A 1RD7A 1DG7A 2XW7A 5HPBA 3DATA 3TQ9A 4FGGA 2CD2A 2P4GA 3S3VA 1LUDA 3SH2A 3D80A 1QZFA 3CLBA 4XT6A 1PD8A 4M7VA 3F8ZA 3FQVA 1J3JA 3HJ3A 5EAJA 3SA1A 1DDSA 1MVTA 2OBCA 4IXGX 4KBNA 5HVEA 2ZZAA 1RX9A 2ANQA 4EILA 4ELFA 3JVXA 1RX3A 4ELBA 1RA2A 2LF1A 1ZDRA 1DRBA 4Q0DA 2C2SA 1M7AA 3LG4A 3I3RA 3QL0A 4H98A 3GYFA 1DLSA 5HQYA 4PDJA 2D5NA 3S7AA 3SA2A 1RA9A 1KMSA 3FRDX 1JOLA 4XT7A 1RX2A 4KFJA 2KGKA 3RO9A 4QI9A 1RA1A 4HA7A 4H95A 3NXYA 3TQ8A 4NX6A 1U70A 3NXTA 1KMVA 1SEJA 4DP3A 3GI2A 3OAFA 4ELEA 4KM0A 5ECCA 1DYRA 3FREX 1RC4A 1DG5A 1AO8A 3SAIA 4KY8A 3EEJA 1CZ3A 2HQPA 3DL5A 4EJ1A 4KJKA 4DPDA 3F0QX 4PSSA 3IX9A 3JWMA 1BOZA 3IRMA 4OR7A 3FRFX 3JW3A 1RX6A 5E8QA 1RG7A 4GH8A 3KFYA 1DYIA 4M6LA 2H2QA 1TDRA 1DR3A 3EEKA 5HF0X 3NZAX 2W3WA 5JA3A 3DL6A 3RG9A 4I1NA
chains in the Genus database with same CATH superfamily
3E0BA 3ZPGA 3NRRA 1JOMA 1DG8A 3SRSX 3D84X 2L28A 1VJ3A 4QJZD 1DR6A 3QG2A 3JWCA 4LEKX 3K45A 7DFRA 4H97A 3QFXA 4CD2A 2BL9A 3IRNA 2G6VA 5ECXA 5DFRA 1U71A 4EIZA 3QLRA 5U26A 4KAKA 3S9UA 3FQOA 1LY3A 4QLEA 1D1GA 1E26A 3UM8A 4HOFA 5HT5A 2BLCA 3M09A 3FQ0A 3Q1HA 4OSGA 3FYVX 1IA4A 3OCHA 3M08A 4PSTA 1DHFA 3FY9X 3QLXA 3NZ6X 2INQA 4M2XA 4M6KA 1DR1A 2W3MA 3INVA 3NTZA 6DFRA 1PDBA 1RH3A 3QLWA 2BLAA 3KJSA 4TU5X 3FRAX 5U27A 1S3UA 5HQZA 1RB3A 4QHVA 4LAHX 3VCOA 3UM5A 3NXOA 2FZHA 4X5FA 1YHOA 1U72A 3HBBA 4LAEX 2JYBA 3SGYA 4ECKA 1DR7A 5HUIA 1DREA 4P68A 3UM6A 3JTWA 4XECX 2HXVA 3IA4A 1DRAA 4G3MA 3F0VX 4HOGA 2ITHA 3TQBA 3GHWA 3KGYA 3FY8X 4RGCA 3FQCA 3ZPCA 1AI9A 3F0XX 2W9SA 2ANOA 1DYJA 1RX4A 3NXXA 4IXFX 3NXVA 3QGTA 1RF7A 3IA5A 3NZBX 4P3RA 3IROA 1RX8A 4X5GA 1RX7A 4KNEA 3FL9A 3NU0A 3JWKA 5JG0X 3F0BX 5HSRA 1S3YA 1DF7A 3SRRX 1J3KA 1OHJA 5DXVA 4Q67A 3F0UX 2W3BA 3EELA 2HM9A 4FHBA 3L3RA 1IA3A 4IXED 3SQYX 1DISA 3QLSA 3FS6A 4EIGA 3JW5A 1DR5A 3K2HA 5HI6A 3FQZA 4XRBA 3FYWX 4PTJA 1VDRA 3KJRA 1HFRA 3F0SX 1RA8A 3QL3A 2W9HA 5CC9A 2W9TA 4QLGA 4PSYA 1HFQA 1S3VA 1HFPA 3DGAA 5HF2X 3QYLA 1DLRA 1OHKA 1JUVA 4KJLA 4Q6AA 4PTHA 3DFRA 8DFRA 4NX7A 1CD2A 4X5IA 1J3IA 1RA3A 3SRWX 3EEMA 4M7UA 1IA1A 1RB2A 3KY8A 2O7PA 3NZ9X 4ELGA 3SRUX 1DR2A 1DRFA 4XE6X 2GD9A 3ROAA 4KM2A 1DHJA 3I8AX 3NXRA 4G95A 4KY4A 1MVSA 2AZNA 4KLXA 3FQFA 1RE7A 3CSEA 2D0KA 2CIGA 3SR5X 3K47A 1DYHA 1LY4A 2FZIA 1M78A 1IA2A 2W3VA 4HA9A 5HSUA 4KYAA 4G8ZX 4KJJA 3TD8A 3DAUA 3JSUA 4ELHA 2QK8A 1KLKA 3EX8A 4DPHA 2FZJA 3FL8A 3CD2A 4DFRA 1DR4A 4HOEA 4P3QA 3QLYA 3SRQX 3K74A 5HVBA 1DAJA 3DRCA 3DG8A 1DIUA 5HT4A 4LAGX 2B3ZA 2W3AA 3N0HA 3GHVA 3EIGA 4X5HA 3JWFA 1RX1A 1DRHA 3QYOA 4P66A 1AOEA 1PD9A 1S3WA 3GHCA 2OIPA 5CCCA 3NZCX 4KD7A 4XT4A 3F8YA 2BLBA 4Q0EA 1M79A 2DRCA 3F91A 5FDAA 4XT8A 4M6JA 3TQAA 3FRBX 1DHIA 4QJCA 2C2TA 4I13A 4FGHA 3CL9A 1DDRA 4QLFA 1BZFA 4XT5A 4KEBA 3NZDA 4H96A 3R33A 2DHFA 4KL9A 4X5JA 2W9GA 3QLZA 4DDRA 1RX5A 1RD7A 1DG7A 2XW7A 5HPBA 3DATA 3TQ9A 4FGGA 2CD2A 2P4GA 3S3VA 1LUDA 3SH2A 3D80A 1QZFA 3CLBA 4XT6A 1PD8A 4M7VA 3F8ZA 3FQVA 1J3JA 3HJ3A 5EAJA 3SA1A 1DDSA 1MVTA 2OBCA 4IXGX 4KBNA 5HVEA 2ZZAA 1RX9A 2ANQA 4EILA 4ELFA 3JVXA 1RX3A 4ELBA 1RA2A 2LF1A 1ZDRA 1DRBA 4Q0DA 2C2SA 1M7AA 3LG4A 3I3RA 3QL0A 4H98A 3GYFA 1DLSA 5HQYA 4PDJA 2D5NA 3S7AA 3SA2A 1RA9A 1KMSA 3FRDX 1JOLA 4XT7A 1RX2A 4KFJA 2KGKA 3RO9A 4QI9A 1RA1A 4HA7A 4H95A 3NXYA 3TQ8A 4NX6A 1U70A 3NXTA 1KMVA 1SEJA 4DP3A 3GI2A 3OAFA 4ELEA 4KM0A 5ECCA 1DYRA 3FREX 1RC4A 1DG5A 1AO8A 3SAIA 4KY8A 3EEJA 1CZ3A 2HQPA 3DL5A 4EJ1A 4KJKA 4DPDA 3F0QX 4PSSA 3IX9A 3JWMA 1BOZA 3IRMA 4OR7A 3FRFX 3JW3A 1RX6A 5E8QA 1RG7A 4GH8A 3KFYA 1DYIA 4M6LA 2H2QA 1TDRA 1DR3A 3EEKA 5HF0X 3NZAX 2W3WA 5JA3A 3DL6A 3RG9A 4I1NA
chains in the Genus database with same CATH topology
3E0BA 3ZPGA 3NRRA 1JOMA 1DG8A 3SRSX 3D84X 2L28A 1VJ3A 4QJZD 1DR6A 3QG2A 3JWCA 4LEKX 3K45A 7DFRA 4H97A 3QFXA 4CD2A 2BL9A 3IRNA 2G6VA 5ECXA 5DFRA 1U71A 4EIZA 3QLRA 5U26A 4KAKA 3S9UA 3FQOA 1LY3A 4QLEA 1D1GA 1E26A 3UM8A 4HOFA 5HT5A 2BLCA 3M09A 3FQ0A 3Q1HA 4OSGA 3FYVX 1IA4A 3OCHA 3M08A 4PSTA 1DHFA 3FY9X 3QLXA 3NZ6X 2INQA 4M2XA 4M6KA 1DR1A 2W3MA 3INVA 3NTZA 6DFRA 1PDBA 1RH3A 3QLWA 2BLAA 3KJSA 4TU5X 3FRAX 5U27A 1S3UA 5HQZA 1RB3A 4QHVA 4LAHX 3VCOA 3UM5A 3NXOA 2FZHA 4X5FA 1YHOA 1U72A 3HBBA 4LAEX 2JYBA 3SGYA 4ECKA 1DR7A 5HUIA 1DREA 4P68A 3UM6A 3JTWA 4XECX 2HXVA 3IA4A 1DRAA 4G3MA 3F0VX 4HOGA 2ITHA 3TQBA 3GHWA 3KGYA 3FY8X 4RGCA 3FQCA 3ZPCA 1AI9A 3F0XX 2W9SA 2ANOA 1DYJA 1RX4A 3NXXA 4IXFX 3NXVA 3QGTA 1RF7A 3IA5A 3NZBX 4P3RA 3IROA 1RX8A 4X5GA 1RX7A 4KNEA 3FL9A 3NU0A 3JWKA 5JG0X 3F0BX 5HSRA 1S3YA 1DF7A 3SRRX 1J3KA 1OHJA 5DXVA 4Q67A 3F0UX 2W3BA 3EELA 2HM9A 4FHBA 3L3RA 1IA3A 4IXED 3SQYX 1DISA 3QLSA 3FS6A 4EIGA 3JW5A 1DR5A 3K2HA 5HI6A 3FQZA 4XRBA 3FYWX 4PTJA 1VDRA 3KJRA 1HFRA 3F0SX 1RA8A 3QL3A 2W9HA 5CC9A 2W9TA 4QLGA 4PSYA 1HFQA 1S3VA 1HFPA 3DGAA 5HF2X 3QYLA 1DLRA 1OHKA 1JUVA 4KJLA 4Q6AA 4PTHA 3DFRA 8DFRA 4NX7A 1CD2A 4X5IA 1J3IA 1RA3A 3SRWX 3EEMA 4M7UA 1IA1A 1RB2A 3KY8A 2O7PA 3NZ9X 4ELGA 3SRUX 1DR2A 1DRFA 4XE6X 2GD9A 3ROAA 4KM2A 1DHJA 3I8AX 3NXRA 4G95A 4KY4A 1MVSA 2AZNA 4KLXA 3FQFA 1RE7A 3CSEA 2D0KA 2CIGA 3SR5X 3K47A 1DYHA 1LY4A 2FZIA 1M78A 1IA2A 2W3VA 4HA9A 5HSUA 4KYAA 4G8ZX 4KJJA 3TD8A 3DAUA 3JSUA 4ELHA 2QK8A 1KLKA 3EX8A 4DPHA 2FZJA 3FL8A 3CD2A 4DFRA 1DR4A 4HOEA 4P3QA 3QLYA 3SRQX 3K74A 5HVBA 1DAJA 3DRCA 3DG8A 1DIUA 5HT4A 4LAGX 2B3ZA 2W3AA 3N0HA 3GHVA 3EIGA 4X5HA 3JWFA 1RX1A 1DRHA 3QYOA 4P66A 1AOEA 1PD9A 1S3WA 3GHCA 2OIPA 5CCCA 3NZCX 4KD7A 4XT4A 3F8YA 2BLBA 4Q0EA 1M79A 2DRCA 3F91A 5FDAA 4XT8A 4M6JA 3TQAA 3FRBX 1DHIA 4QJCA 2C2TA 4I13A 4FGHA 3CL9A 1DDRA 4QLFA 1BZFA 4XT5A 4KEBA 3NZDA 4H96A 3R33A 2DHFA 4KL9A 4X5JA 2W9GA 3QLZA 4DDRA 1RX5A 1RD7A 1DG7A 2XW7A 5HPBA 3DATA 3TQ9A 4FGGA 2CD2A 2P4GA 3S3VA 1LUDA 3SH2A 3D80A 1QZFA 3CLBA 4XT6A 1PD8A 4M7VA 3F8ZA 3FQVA 1J3JA 3HJ3A 5EAJA 3SA1A 1DDSA 1MVTA 2OBCA 4IXGX 4KBNA 5HVEA 2ZZAA 1RX9A 2ANQA 4EILA 4ELFA 3JVXA 1RX3A 4ELBA 1RA2A 2LF1A 1ZDRA 1DRBA 4Q0DA 2C2SA 1M7AA 3LG4A 3I3RA 3QL0A 4H98A 3GYFA 1DLSA 5HQYA 4PDJA 2D5NA 3S7AA 3SA2A 1RA9A 1KMSA 3FRDX 1JOLA 4XT7A 1RX2A 4KFJA 2KGKA 3RO9A 4QI9A 1RA1A 4HA7A 4H95A 3NXYA 3TQ8A 4NX6A 1U70A 3NXTA 1KMVA 1SEJA 4DP3A 3GI2A 3OAFA 4ELEA 4KM0A 5ECCA 1DYRA 3FREX 1RC4A 1DG5A 1AO8A 3SAIA 4KY8A 3EEJA 1CZ3A 2HQPA 3DL5A 4EJ1A 4KJKA 4DPDA 3F0QX 4PSSA 3IX9A 3JWMA 1BOZA 3IRMA 4OR7A 3FRFX 3JW3A 1RX6A 5E8QA 1RG7A 4GH8A 3KFYA 1DYIA 4M6LA 2H2QA 1TDRA 1DR3A 3EEKA 5HF0X 3NZAX 2W3WA 5JA3A 3DL6A 3RG9A 4I1NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E0B A;  3ZPG A;  3NRR A;  1JOM A;  1DG8 A;  3SRS X;  3D84 X;  2L28 A;  1VJ3 A;  4QJZ D;  1DR6 A;  3QG2 A;  3JWC A;  4LEK X;  3K45 A;  7DFR A;  4H97 A;  3QFX A;  4CD2 A;  2BL9 A;  3IRN A;  2G6V A;  5ECX A;  5DFR A;  1U71 A;  4EIZ A;  3QLR A;  5U26 A;  4KAK A;  3S9U A;  3FQO A;  1LY3 A;  4QLE A;  1D1G A;  1E26 A;  3UM8 A;  4HOF A;  5HT5 A;  2BLC A;  3M09 A;  3FQ0 A;  3Q1H A;  4OSG A;  3FYV X;  1IA4 A;  3OCH A;  3M08 A;  4PST A;  1DHF A;  3FY9 X;  3QLX A;  3NZ6 X;  2INQ A;  4M2X A;  4M6K A;  1DR1 A;  2W3M A;  3INV A;  3NTZ A;  6DFR A;  1PDB A;  1RH3 A;  3QLW A;  2BLA A;  3KJS A;  4TU5 X;  3FRA X;  5U27 A;  1S3U A;  5HQZ A;  1RB3 A;  4QHV A;  4LAH X;  3VCO A;  3UM5 A;  3NXO A;  2FZH A;  4X5F A;  1YHO A;  1U72 A;  3HBB A;  4LAE X;  2JYB A;  3SGY A;  4ECK A;  1DR7 A;  5HUI A;  1DRE A;  4P68 A;  3UM6 A;  3JTW A;  4XEC X;  2HXV A;  3IA4 A;  1DRA A;  4G3M A;  3F0V X;  4HOG A;  2ITH A;  3TQB A;  3GHW A;  3KGY A;  3FY8 X;  4RGC A;  3FQC A;  3ZPC A;  1AI9 A;  3F0X X;  2W9S A;  2ANO A;  1DYJ A;  1RX4 A;  3NXX A;  4IXF X;  3NXV A;  3QGT A;  1RF7 A;  3IA5 A;  3NZB X;  4P3R A;  3IRO A;  1RX8 A;  4X5G A;  1RX7 A;  4KNE A;  3FL9 A;  3NU0 A;  3JWK A;  5JG0 X;  3F0B X;  5HSR A;  1S3Y A;  1DF7 A;  3SRR X;  1J3K A;  1OHJ A;  5DXV A;  4Q67 A;  3F0U X;  2W3B A;  3EEL A;  2HM9 A;  4FHB A;  3L3R A;  1IA3 A;  4IXE D;  3SQY X;  1DIS A;  3QLS A;  3FS6 A;  4EIG A;  3JW5 A;  1DR5 A;  3K2H A;  5HI6 A;  3FQZ A;  4XRB A;  3FYW X;  4PTJ A;  1VDR A;  3KJR A;  1HFR A;  3F0S X;  1RA8 A;  3QL3 A;  2W9H A;  5CC9 A;  2W9T A;  4QLG A;  4PSY A;  1HFQ A;  1S3V A;  1HFP A;  3DGA A;  5HF2 X;  3QYL A;  1DLR A;  1OHK A;  1JUV A;  4KJL A;  4Q6A A;  4PTH A;  3DFR A;  8DFR A;  4NX7 A;  1CD2 A;  4X5I A;  1J3I A;  1RA3 A;  3SRW X;  3EEM A;  4M7U A;  1IA1 A;  1RB2 A;  3KY8 A;  2O7P A;  3NZ9 X;  4ELG A;  3SRU X;  1DR2 A;  1DRF A;  4XE6 X;  2GD9 A;  3ROA A;  4KM2 A;  1DHJ A;  3I8A X;  3NXR A;  4G95 A;  4KY4 A;  1MVS A;  2AZN A;  4KLX A;  3FQF A;  1RE7 A;  3CSE A;  2D0K A;  2CIG A;  3SR5 X;  3K47 A;  1DYH A;  1LY4 A;  2FZI A;  1M78 A;  1IA2 A;  2W3V A;  4HA9 A;  5HSU A;  4KYA A;  4G8Z X;  4KJJ A;  3TD8 A;  3DAU A;  3JSU A;  4ELH A;  2QK8 A;  1KLK A;  3EX8 A;  4DPH A;  2FZJ A;  3FL8 A;  3CD2 A;  4DFR A;  1DR4 A;  4HOE A;  4P3Q A;  3QLY A;  3SRQ X;  3K74 A;  5HVB A;  1DAJ A;  3DRC A;  3DG8 A;  1DIU A;  5HT4 A;  4LAG X;  2B3Z A;  2W3A A;  3N0H A;  3GHV A;  3EIG A;  4X5H A;  3JWF A;  1RX1 A;  1DRH A;  3QYO A;  4P66 A;  1AOE A;  1PD9 A;  1S3W A;  3GHC A;  2OIP A;  5CCC A;  3NZC X;  4KD7 A;  4XT4 A;  3F8Y A;  2BLB A;  4Q0E A;  1M79 A;  2DRC A;  3F91 A;  5FDA A;  4XT8 A;  4M6J A;  3TQA A;  3FRB X;  1DHI A;  4QJC A;  2C2T A;  4I13 A;  4FGH A;  3CL9 A;  1DDR A;  4QLF A;  1BZF A;  4XT5 A;  4KEB A;  3NZD A;  4H96 A;  3R33 A;  2DHF A;  4KL9 A;  4X5J A;  2W9G A;  3QLZ A;  4DDR A;  1RX5 A;  1RD7 A;  1DG7 A;  2XW7 A;  5HPB A;  3DAT A;  3TQ9 A;  4FGG A;  2CD2 A;  2P4G A;  3S3V A;  1LUD A;  3SH2 A;  3D80 A;  1QZF A;  3CLB A;  4XT6 A;  1PD8 A;  4M7V A;  3F8Z A;  3FQV A;  1J3J A;  3HJ3 A;  5EAJ A;  3SA1 A;  1DDS A;  1MVT A;  2OBC A;  4IXG X;  4KBN A;  5HVE A;  2ZZA A;  1RX9 A;  2ANQ A;  4EIL A;  4ELF A;  3JVX A;  1RX3 A;  4ELB A;  1RA2 A;  2LF1 A;  1ZDR A;  1DRB A;  4Q0D A;  2C2S A;  1M7A A;  3LG4 A;  3I3R A;  3QL0 A;  4H98 A;  3GYF A;  1DLS A;  5HQY A;  4PDJ A;  2D5N A;  3S7A A;  3SA2 A;  1RA9 A;  1KMS A;  3FRD X;  1JOL A;  4XT7 A;  1RX2 A;  4KFJ A;  2KGK A;  3RO9 A;  4QI9 A;  1RA1 A;  4HA7 A;  4H95 A;  3NXY A;  3TQ8 A;  4NX6 A;  1U70 A;  3NXT A;  1KMV A;  1SEJ A;  4DP3 A;  3GI2 A;  3OAF A;  4ELE A;  4KM0 A;  5ECC A;  1DYR A;  3FRE X;  1RC4 A;  1DG5 A;  1AO8 A;  3SAI A;  4KY8 A;  3EEJ A;  1CZ3 A;  2HQP A;  3DL5 A;  4EJ1 A;  4KJK A;  4DPD A;  3F0Q X;  4PSS A;  3IX9 A;  3JWM A;  1BOZ A;  3IRM A;  4OR7 A;  3FRF X;  3JW3 A;  1RX6 A;  5E8Q A;  1RG7 A;  4GH8 A;  3KFY A;  1DYI A;  4M6L A;  2H2Q A;  1TDR A;  1DR3 A;  3EEK A;  5HF0 X;  3NZA X;  2W3W A;  5JA3 A;  3DL6 A;  3RG9 A;  4I1N A; 
#chains in the Genus database with same CATH topology
 3E0B A;  3ZPG A;  3NRR A;  1JOM A;  1DG8 A;  3SRS X;  3D84 X;  2L28 A;  1VJ3 A;  4QJZ D;  1DR6 A;  3QG2 A;  3JWC A;  4LEK X;  3K45 A;  7DFR A;  4H97 A;  3QFX A;  4CD2 A;  2BL9 A;  3IRN A;  2G6V A;  5ECX A;  5DFR A;  1U71 A;  4EIZ A;  3QLR A;  5U26 A;  4KAK A;  3S9U A;  3FQO A;  1LY3 A;  4QLE A;  1D1G A;  1E26 A;  3UM8 A;  4HOF A;  5HT5 A;  2BLC A;  3M09 A;  3FQ0 A;  3Q1H A;  4OSG A;  3FYV X;  1IA4 A;  3OCH A;  3M08 A;  4PST A;  1DHF A;  3FY9 X;  3QLX A;  3NZ6 X;  2INQ A;  4M2X A;  4M6K A;  1DR1 A;  2W3M A;  3INV A;  3NTZ A;  6DFR A;  1PDB A;  1RH3 A;  3QLW A;  2BLA A;  3KJS A;  4TU5 X;  3FRA X;  5U27 A;  1S3U A;  5HQZ A;  1RB3 A;  4QHV A;  4LAH X;  3VCO A;  3UM5 A;  3NXO A;  2FZH A;  4X5F A;  1YHO A;  1U72 A;  3HBB A;  4LAE X;  2JYB A;  3SGY A;  4ECK A;  1DR7 A;  5HUI A;  1DRE A;  4P68 A;  3UM6 A;  3JTW A;  4XEC X;  2HXV A;  3IA4 A;  1DRA A;  4G3M A;  3F0V X;  4HOG A;  2ITH A;  3TQB A;  3GHW A;  3KGY A;  3FY8 X;  4RGC A;  3FQC A;  3ZPC A;  1AI9 A;  3F0X X;  2W9S A;  2ANO A;  1DYJ A;  1RX4 A;  3NXX A;  4IXF X;  3NXV A;  3QGT A;  1RF7 A;  3IA5 A;  3NZB X;  4P3R A;  3IRO A;  1RX8 A;  4X5G A;  1RX7 A;  4KNE A;  3FL9 A;  3NU0 A;  3JWK A;  5JG0 X;  3F0B X;  5HSR A;  1S3Y A;  1DF7 A;  3SRR X;  1J3K A;  1OHJ A;  5DXV A;  4Q67 A;  3F0U X;  2W3B A;  3EEL A;  2HM9 A;  4FHB A;  3L3R A;  1IA3 A;  4IXE D;  3SQY X;  1DIS A;  3QLS A;  3FS6 A;  4EIG A;  3JW5 A;  1DR5 A;  3K2H A;  5HI6 A;  3FQZ A;  4XRB A;  3FYW X;  4PTJ A;  1VDR A;  3KJR A;  1HFR A;  3F0S X;  1RA8 A;  3QL3 A;  2W9H A;  5CC9 A;  2W9T A;  4QLG A;  4PSY A;  1HFQ A;  1S3V A;  1HFP A;  3DGA A;  5HF2 X;  3QYL A;  1DLR A;  1OHK A;  1JUV A;  4KJL A;  4Q6A A;  4PTH A;  3DFR A;  8DFR A;  4NX7 A;  1CD2 A;  4X5I A;  1J3I A;  1RA3 A;  3SRW X;  3EEM A;  4M7U A;  1IA1 A;  1RB2 A;  3KY8 A;  2O7P A;  3NZ9 X;  4ELG A;  3SRU X;  1DR2 A;  1DRF A;  4XE6 X;  2GD9 A;  3ROA A;  4KM2 A;  1DHJ A;  3I8A X;  3NXR A;  4G95 A;  4KY4 A;  1MVS A;  2AZN A;  4KLX A;  3FQF A;  1RE7 A;  3CSE A;  2D0K A;  2CIG A;  3SR5 X;  3K47 A;  1DYH A;  1LY4 A;  2FZI A;  1M78 A;  1IA2 A;  2W3V A;  4HA9 A;  5HSU A;  4KYA A;  4G8Z X;  4KJJ A;  3TD8 A;  3DAU A;  3JSU A;  4ELH A;  2QK8 A;  1KLK A;  3EX8 A;  4DPH A;  2FZJ A;  3FL8 A;  3CD2 A;  4DFR A;  1DR4 A;  4HOE A;  4P3Q A;  3QLY A;  3SRQ X;  3K74 A;  5HVB A;  1DAJ A;  3DRC A;  3DG8 A;  1DIU A;  5HT4 A;  4LAG X;  2B3Z A;  2W3A A;  3N0H A;  3GHV A;  3EIG A;  4X5H A;  3JWF A;  1RX1 A;  1DRH A;  3QYO A;  4P66 A;  1AOE A;  1PD9 A;  1S3W A;  3GHC A;  2OIP A;  5CCC A;  3NZC X;  4KD7 A;  4XT4 A;  3F8Y A;  2BLB A;  4Q0E A;  1M79 A;  2DRC A;  3F91 A;  5FDA A;  4XT8 A;  4M6J A;  3TQA A;  3FRB X;  1DHI A;  4QJC A;  2C2T A;  4I13 A;  4FGH A;  3CL9 A;  1DDR A;  4QLF A;  1BZF A;  4XT5 A;  4KEB A;  3NZD A;  4H96 A;  3R33 A;  2DHF A;  4KL9 A;  4X5J A;  2W9G A;  3QLZ A;  4DDR A;  1RX5 A;  1RD7 A;  1DG7 A;  2XW7 A;  5HPB A;  3DAT A;  3TQ9 A;  4FGG A;  2CD2 A;  2P4G A;  3S3V A;  1LUD A;  3SH2 A;  3D80 A;  1QZF A;  3CLB A;  4XT6 A;  1PD8 A;  4M7V A;  3F8Z A;  3FQV A;  1J3J A;  3HJ3 A;  5EAJ A;  3SA1 A;  1DDS A;  1MVT A;  2OBC A;  4IXG X;  4KBN A;  5HVE A;  2ZZA A;  1RX9 A;  2ANQ A;  4EIL A;  4ELF A;  3JVX A;  1RX3 A;  4ELB A;  1RA2 A;  2LF1 A;  1ZDR A;  1DRB A;  4Q0D A;  2C2S A;  1M7A A;  3LG4 A;  3I3R A;  3QL0 A;  4H98 A;  3GYF A;  1DLS A;  5HQY A;  4PDJ A;  2D5N A;  3S7A A;  3SA2 A;  1RA9 A;  1KMS A;  3FRD X;  1JOL A;  4XT7 A;  1RX2 A;  4KFJ A;  2KGK A;  3RO9 A;  4QI9 A;  1RA1 A;  4HA7 A;  4H95 A;  3NXY A;  3TQ8 A;  4NX6 A;  1U70 A;  3NXT A;  1KMV A;  1SEJ A;  4DP3 A;  3GI2 A;  3OAF A;  4ELE A;  4KM0 A;  5ECC A;  1DYR A;  3FRE X;  1RC4 A;  1DG5 A;  1AO8 A;  3SAI A;  4KY8 A;  3EEJ A;  1CZ3 A;  2HQP A;  3DL5 A;  4EJ1 A;  4KJK A;  4DPD A;  3F0Q X;  4PSS A;  3IX9 A;  3JWM A;  1BOZ A;  3IRM A;  4OR7 A;  3FRF X;  3JW3 A;  1RX6 A;  5E8Q A;  1RG7 A;  4GH8 A;  3KFY A;  1DYI A;  4M6L A;  2H2Q A;  1TDR A;  1DR3 A;  3EEK A;  5HF0 X;  3NZA X;  2W3W A;  5JA3 A;  3DL6 A;  3RG9 A;  4I1N A; 
#chains in the Genus database with same CATH homology
 3E0B A;  3ZPG A;  3NRR A;  1JOM A;  1DG8 A;  3SRS X;  3D84 X;  2L28 A;  1VJ3 A;  4QJZ D;  1DR6 A;  3QG2 A;  3JWC A;  4LEK X;  3K45 A;  7DFR A;  4H97 A;  3QFX A;  4CD2 A;  2BL9 A;  3IRN A;  2G6V A;  5ECX A;  5DFR A;  1U71 A;  4EIZ A;  3QLR A;  5U26 A;  4KAK A;  3S9U A;  3FQO A;  1LY3 A;  4QLE A;  1D1G A;  1E26 A;  3UM8 A;  4HOF A;  5HT5 A;  2BLC A;  3M09 A;  3FQ0 A;  3Q1H A;  4OSG A;  3FYV X;  1IA4 A;  3OCH A;  3M08 A;  4PST A;  1DHF A;  3FY9 X;  3QLX A;  3NZ6 X;  2INQ A;  4M2X A;  4M6K A;  1DR1 A;  2W3M A;  3INV A;  3NTZ A;  6DFR A;  1PDB A;  1RH3 A;  3QLW A;  2BLA A;  3KJS A;  4TU5 X;  3FRA X;  5U27 A;  1S3U A;  5HQZ A;  1RB3 A;  4QHV A;  4LAH X;  3VCO A;  3UM5 A;  3NXO A;  2FZH A;  4X5F A;  1YHO A;  1U72 A;  3HBB A;  4LAE X;  2JYB A;  3SGY A;  4ECK A;  1DR7 A;  5HUI A;  1DRE A;  4P68 A;  3UM6 A;  3JTW A;  4XEC X;  2HXV A;  3IA4 A;  1DRA A;  4G3M A;  3F0V X;  4HOG A;  2ITH A;  3TQB A;  3GHW A;  3KGY A;  3FY8 X;  4RGC A;  3FQC A;  3ZPC A;  1AI9 A;  3F0X X;  2W9S A;  2ANO A;  1DYJ A;  1RX4 A;  3NXX A;  4IXF X;  3NXV A;  3QGT A;  1RF7 A;  3IA5 A;  3NZB X;  4P3R A;  3IRO A;  1RX8 A;  4X5G A;  1RX7 A;  4KNE A;  3FL9 A;  3NU0 A;  3JWK A;  5JG0 X;  3F0B X;  5HSR A;  1S3Y A;  1DF7 A;  3SRR X;  1J3K A;  1OHJ A;  5DXV A;  4Q67 A;  3F0U X;  2W3B A;  3EEL A;  2HM9 A;  4FHB A;  3L3R A;  1IA3 A;  4IXE D;  3SQY X;  1DIS A;  3QLS A;  3FS6 A;  4EIG A;  3JW5 A;  1DR5 A;  3K2H A;  5HI6 A;  3FQZ A;  4XRB A;  3FYW X;  4PTJ A;  1VDR A;  3KJR A;  1HFR A;  3F0S X;  1RA8 A;  3QL3 A;  2W9H A;  5CC9 A;  2W9T A;  4QLG A;  4PSY A;  1HFQ A;  1S3V A;  1HFP A;  3DGA A;  5HF2 X;  3QYL A;  1DLR A;  1OHK A;  1JUV A;  4KJL A;  4Q6A A;  4PTH A;  3DFR A;  8DFR A;  4NX7 A;  1CD2 A;  4X5I A;  1J3I A;  1RA3 A;  3SRW X;  3EEM A;  4M7U A;  1IA1 A;  1RB2 A;  3KY8 A;  2O7P A;  3NZ9 X;  4ELG A;  3SRU X;  1DR2 A;  1DRF A;  4XE6 X;  2GD9 A;  3ROA A;  4KM2 A;  1DHJ A;  3I8A X;  3NXR A;  4G95 A;  4KY4 A;  1MVS A;  2AZN A;  4KLX A;  3FQF A;  1RE7 A;  3CSE A;  2D0K A;  2CIG A;  3SR5 X;  3K47 A;  1DYH A;  1LY4 A;  2FZI A;  1M78 A;  1IA2 A;  2W3V A;  4HA9 A;  5HSU A;  4KYA A;  4G8Z X;  4KJJ A;  3TD8 A;  3DAU A;  3JSU A;  4ELH A;  2QK8 A;  1KLK A;  3EX8 A;  4DPH A;  2FZJ A;  3FL8 A;  3CD2 A;  4DFR A;  1DR4 A;  4HOE A;  4P3Q A;  3QLY A;  3SRQ X;  3K74 A;  5HVB A;  1DAJ A;  3DRC A;  3DG8 A;  1DIU A;  5HT4 A;  4LAG X;  2B3Z A;  2W3A A;  3N0H A;  3GHV A;  3EIG A;  4X5H A;  3JWF A;  1RX1 A;  1DRH A;  3QYO A;  4P66 A;  1AOE A;  1PD9 A;  1S3W A;  3GHC A;  2OIP A;  5CCC A;  3NZC X;  4KD7 A;  4XT4 A;  3F8Y A;  2BLB A;  4Q0E A;  1M79 A;  2DRC A;  3F91 A;  5FDA A;  4XT8 A;  4M6J A;  3TQA A;  3FRB X;  1DHI A;  4QJC A;  2C2T A;  4I13 A;  4FGH A;  3CL9 A;  1DDR A;  4QLF A;  1BZF A;  4XT5 A;  4KEB A;  3NZD A;  4H96 A;  3R33 A;  2DHF A;  4KL9 A;  4X5J A;  2W9G A;  3QLZ A;  4DDR A;  1RX5 A;  1RD7 A;  1DG7 A;  2XW7 A;  5HPB A;  3DAT A;  3TQ9 A;  4FGG A;  2CD2 A;  2P4G A;  3S3V A;  1LUD A;  3SH2 A;  3D80 A;  1QZF A;  3CLB A;  4XT6 A;  1PD8 A;  4M7V A;  3F8Z A;  3FQV A;  1J3J A;  3HJ3 A;  5EAJ A;  3SA1 A;  1DDS A;  1MVT A;  2OBC A;  4IXG X;  4KBN A;  5HVE A;  2ZZA A;  1RX9 A;  2ANQ A;  4EIL A;  4ELF A;  3JVX A;  1RX3 A;  4ELB A;  1RA2 A;  2LF1 A;  1ZDR A;  1DRB A;  4Q0D A;  2C2S A;  1M7A A;  3LG4 A;  3I3R A;  3QL0 A;  4H98 A;  3GYF A;  1DLS A;  5HQY A;  4PDJ A;  2D5N A;  3S7A A;  3SA2 A;  1RA9 A;  1KMS A;  3FRD X;  1JOL A;  4XT7 A;  1RX2 A;  4KFJ A;  2KGK A;  3RO9 A;  4QI9 A;  1RA1 A;  4HA7 A;  4H95 A;  3NXY A;  3TQ8 A;  4NX6 A;  1U70 A;  3NXT A;  1KMV A;  1SEJ A;  4DP3 A;  3GI2 A;  3OAF A;  4ELE A;  4KM0 A;  5ECC A;  1DYR A;  3FRE X;  1RC4 A;  1DG5 A;  1AO8 A;  3SAI A;  4KY8 A;  3EEJ A;  1CZ3 A;  2HQP A;  3DL5 A;  4EJ1 A;  4KJK A;  4DPD A;  3F0Q X;  4PSS A;  3IX9 A;  3JWM A;  1BOZ A;  3IRM A;  4OR7 A;  3FRF X;  3JW3 A;  1RX6 A;  5E8Q A;  1RG7 A;  4GH8 A;  3KFY A;  1DYI A;  4M6L A;  2H2Q A;  1TDR A;  1DR3 A;  3EEK A;  5HF0 X;  3NZA X;  2W3W A;  5JA3 A;  3DL6 A;  3RG9 A;  4I1N A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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