4M6JA

Crystal structure of human dihydrofolate reductase (dhfr) bound to nadph
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
184
structure length
184
Chain Sequence
SLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Divergent evolution of protein conformational dynamics in dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 53
structure length 184
sequence length 184
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2013-08-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4m6jA00
3K47A 5DXVA 3K45A 2C2SA 1RA3A 1DISA 3IA4A 2W3MA 2GD9A 4H98A 6DFRA 1RF7A 4FHBA 5HSUA 3TQ9A 3JWCA 1AI9A 4KM2A 3SR5X 1S3WA 5HI6A 1PD9A 1DR5A 3UM5A 2KGKA 4KLXA 3F0XX 4X5HA 3HBBA 3M09A 3ROAA 1S3YA 3QFXA 1OHKA 1DRFA 3I8AX 1RA2A 1DR2A 1DRBA 3EELA 1IA1A 3OAFA 4X5IA 1DR7A 3JSUA 5JA3A 3FY8X 2W9SA 2ZZAA 4OR7A 4DDRA 1DREA 5HVEA 4KJKA 3NXRA 1DF7A 2DRCA 3F0BX 3QLZA 4H96A 2G6VA 4KJLA 1DR1A 1RC4A 4ELBA 1RX7A 3SQYX 3IRMA 2BLAA 3CL9A 4X5JA 3NZBX 1DG8A 1RX9A 3NZCX 1M79A 2ITHA 1DLRA 1QZFA 1BZFA 1ZDRA 3JW5A 4P66A 3SRQX 2ANOA 3UM8A 3GI2A 1DRHA 5HUIA 2O7PA 3NZAX 1J3KA 2OIPA 3SA1A 4PSYA 2B3ZA 3RG9A 1DRAA 2W9TA 5JG0X 4HOGA 1U71A 2HM9A 1JUVA 4ELHA 5HF0X 1U70A 4XT4A 4P3RA 1SEJA 1S3VA 1LY3A 4LEKX 3NZDA 3GHWA 2FZJA 1PDBA 4QJZD 2ANQA 3L3RA 2W3AA 4KM0A 4M6LA 4GH8A 4PDJA 3JW3A 5U26A 3DG8A 2W3WA 4M6JA 3CLBA 3DRCA 1U72A 4OSGA 4HA7A 3FL9A 3VCOA 2CIGA 1S3UA 2D0KA 4H95A 1AOEA 1LY4A 4NX6A 3SA2A 3DATA 3F0UX 3N0HA 3DGAA 1BOZA 1DG5A 1RX5A 1TDRA 3DAUA 1DR4A 4ECKA 4P68A 1PD8A 1RX3A 3GHCA 3IX9A 1DAJA 3F0VX 2HXVA 3ZPCA 4HOEA 3JWMA 4Q0DA 4H97A 1CD2A 1M7AA 3SRRX 4KFJA 4DP3A 3EEMA 1RG7A 3IA5A 3Q1HA 3KGYA 3F91A 1E26A 3FY9X 3KJRA 4PTHA 4HOFA 1KMVA 5FDAA 2AZNA 2W9GA 1HFQA 1RB3A 3NXXA 4KY4A 4NX7A 4XECX 3DL6A 1DYRA 5EAJA 3INVA 3SRUX 1VDRA 3NXTA 4DFRA 3NZ9X 5HF2X 4QHVA 1RX4A 1D1GA 3FQVA 4Q0EA 5HT4A 2JYBA 3D84X 3ZPGA 4M7UA 3NRRA 4ELFA 1LUDA 3EEKA 4FGGA 4M6KA 3CD2A 4ELEA 3QL0A 4X5GA 1RD7A 1IA2A 4KY8A 2BL9A 3HJ3A 1DYHA 4LAEX 3OCHA 1RX2A 2D5NA 1RX6A 1CZ3A 7DFRA 3FRFX 4KJJA 3QG2A 3QLXA 2CD2A 3NXYA 4P3QA 2C2TA 3F0SX 4ELGA 5CCCA 3FQ0A 1VJ3A 4PTJA 4LAHX 3DL5A 1MVTA 3RO9A 2LF1A 1RE7A 3FRBX 4G95A 3FQCA 1J3IA 3SAIA 3K2HA 3KFYA 2INQA 3F8YA 4XT8A 3EX8A 1DIUA 3E0BA 3F0QX 3IRNA 4IXED 1IA3A 4XRBA 4CD2A 3NXOA 4XT5A 1DYJA 4M2XA 1RA8A 3FYWX 4PSTA 2W9HA 1KLKA 1IA4A 3QLYA 4Q67A 4EIGA 3JVXA 4TU5X 5HQZA 4Q6AA 3GYFA 4IXFX 5HSRA 3D80A 1RH3A 3TD8A 4G3MA 4I1NA 4FGHA 4XE6X 1DHIA 3S3VA 1DDRA 1M78A 5E8QA 4KBNA 2DHFA 3QYLA 4QI9A 4EJ1A 1RX8A 3SRWX 3TQAA 4QLEA 3NXVA 1AO8A 4KAKA 8DFRA 1HFPA 5CC9A 3JWFA 3TQ8A 3FYVX 4KL9A 2QK8A 4KEBA 2W3VA 3FQZA 4KD7A 3EEJA 1DYIA 1DDSA 4EIZA 3FRAX 4PSSA 3GHVA 1YHOA 1DHFA 3FRDX 5ECXA 3NZ6X 4IXGX 5U27A 3SRSX 4LAGX 3K74A 4QLGA 3F8ZA 2L28A 1DG7A 5HPBA 3JTWA 4KNEA 1RA9A 3CSEA 2OBCA 4QJCA 4RGCA 5DFRA 4XT6A 4I13A 3QYOA 4X5FA 3DFRA 3R33A 2P4GA 1DR3A 3LG4A 2FZHA 3QLRA 3JWKA 3FL8A 1DLSA 2FZIA 1RA1A 1RX1A 2W3BA 3I3RA 5HVBA 3FQOA 3QLWA 5ECCA 3FREX 3M08A 3UM6A 1J3JA 4G8ZX 3FS6A 2H2QA 3IROA 3TQBA 3QGTA 4EILA 4DPDA 3KJSA 3EIGA 2BLBA 3S7AA 1JOMA 1MVSA 1OHJA 3QL3A 3QLSA 3NTZA 4M7VA 3FQFA 1DR6A 3NU0A 5HT5A 3S9UA 2XW7A 4XT7A 3SGYA 4DPHA 1HFRA 1KMSA 2HQPA 4QLFA 1JOLA 2BLCA 3KY8A 3SH2A 4HA9A 5HQYA 1DHJA 1RB2A 4KYAA
chains in the Genus database with same CATH superfamily
3K47A 5DXVA 3K45A 2C2SA 1RA3A 1DISA 3IA4A 2W3MA 2GD9A 4H98A 6DFRA 1RF7A 4FHBA 5HSUA 3TQ9A 3JWCA 1AI9A 4KM2A 3SR5X 1S3WA 5HI6A 1PD9A 1DR5A 3UM5A 2KGKA 4KLXA 3F0XX 4X5HA 3HBBA 3M09A 3ROAA 1S3YA 3QFXA 1OHKA 1DRFA 3I8AX 1RA2A 1DR2A 1DRBA 3EELA 1IA1A 3OAFA 4X5IA 1DR7A 3JSUA 5JA3A 3FY8X 2W9SA 2ZZAA 4OR7A 4DDRA 1DREA 5HVEA 4KJKA 3NXRA 1DF7A 2DRCA 3F0BX 3QLZA 4H96A 2G6VA 4KJLA 1DR1A 1RC4A 4ELBA 1RX7A 3SQYX 3IRMA 2BLAA 3CL9A 4X5JA 3NZBX 1DG8A 1RX9A 3NZCX 1M79A 2ITHA 1DLRA 1QZFA 1BZFA 1ZDRA 3JW5A 4P66A 3SRQX 2ANOA 3UM8A 3GI2A 1DRHA 5HUIA 2O7PA 3NZAX 1J3KA 2OIPA 3SA1A 4PSYA 2B3ZA 3RG9A 1DRAA 2W9TA 5JG0X 4HOGA 1U71A 2HM9A 1JUVA 4ELHA 5HF0X 1U70A 4XT4A 4P3RA 1SEJA 1S3VA 1LY3A 4LEKX 3NZDA 3GHWA 2FZJA 1PDBA 4QJZD 2ANQA 3L3RA 2W3AA 4KM0A 4M6LA 4GH8A 4PDJA 3JW3A 5U26A 3DG8A 2W3WA 4M6JA 3CLBA 3DRCA 1U72A 4OSGA 4HA7A 3FL9A 3VCOA 2CIGA 1S3UA 2D0KA 4H95A 1AOEA 1LY4A 4NX6A 3SA2A 3DATA 3F0UX 3N0HA 3DGAA 1BOZA 1DG5A 1RX5A 1TDRA 3DAUA 1DR4A 4ECKA 4P68A 1PD8A 1RX3A 3GHCA 3IX9A 1DAJA 3F0VX 2HXVA 3ZPCA 4HOEA 3JWMA 4Q0DA 4H97A 1CD2A 1M7AA 3SRRX 4KFJA 4DP3A 3EEMA 1RG7A 3IA5A 3Q1HA 3KGYA 3F91A 1E26A 3FY9X 3KJRA 4PTHA 4HOFA 1KMVA 5FDAA 2AZNA 2W9GA 1HFQA 1RB3A 3NXXA 4KY4A 4NX7A 4XECX 3DL6A 1DYRA 5EAJA 3INVA 3SRUX 1VDRA 3NXTA 4DFRA 3NZ9X 5HF2X 4QHVA 1RX4A 1D1GA 3FQVA 4Q0EA 5HT4A 2JYBA 3D84X 3ZPGA 4M7UA 3NRRA 4ELFA 1LUDA 3EEKA 4FGGA 4M6KA 3CD2A 4ELEA 3QL0A 4X5GA 1RD7A 1IA2A 4KY8A 2BL9A 3HJ3A 1DYHA 4LAEX 3OCHA 1RX2A 2D5NA 1RX6A 1CZ3A 7DFRA 3FRFX 4KJJA 3QG2A 3QLXA 2CD2A 3NXYA 4P3QA 2C2TA 3F0SX 4ELGA 5CCCA 3FQ0A 1VJ3A 4PTJA 4LAHX 3DL5A 1MVTA 3RO9A 2LF1A 1RE7A 3FRBX 4G95A 3FQCA 1J3IA 3SAIA 3K2HA 3KFYA 2INQA 3F8YA 4XT8A 3EX8A 1DIUA 3E0BA 3F0QX 3IRNA 4IXED 1IA3A 4XRBA 4CD2A 3NXOA 4XT5A 1DYJA 4M2XA 1RA8A 3FYWX 4PSTA 2W9HA 1KLKA 1IA4A 3QLYA 4Q67A 4EIGA 3JVXA 4TU5X 5HQZA 4Q6AA 3GYFA 4IXFX 5HSRA 3D80A 1RH3A 3TD8A 4G3MA 4I1NA 4FGHA 4XE6X 1DHIA 3S3VA 1DDRA 1M78A 5E8QA 4KBNA 2DHFA 3QYLA 4QI9A 4EJ1A 1RX8A 3SRWX 3TQAA 4QLEA 3NXVA 1AO8A 4KAKA 8DFRA 1HFPA 5CC9A 3JWFA 3TQ8A 3FYVX 4KL9A 2QK8A 4KEBA 2W3VA 3FQZA 4KD7A 3EEJA 1DYIA 1DDSA 4EIZA 3FRAX 4PSSA 3GHVA 1YHOA 1DHFA 3FRDX 5ECXA 3NZ6X 4IXGX 5U27A 3SRSX 4LAGX 3K74A 4QLGA 3F8ZA 2L28A 1DG7A 5HPBA 3JTWA 4KNEA 1RA9A 3CSEA 2OBCA 4QJCA 4RGCA 5DFRA 4XT6A 4I13A 3QYOA 4X5FA 3DFRA 3R33A 2P4GA 1DR3A 3LG4A 2FZHA 3QLRA 3JWKA 3FL8A 1DLSA 2FZIA 1RA1A 1RX1A 2W3BA 3I3RA 5HVBA 3FQOA 3QLWA 5ECCA 3FREX 3M08A 3UM6A 1J3JA 4G8ZX 3FS6A 2H2QA 3IROA 3TQBA 3QGTA 4EILA 4DPDA 3KJSA 3EIGA 2BLBA 3S7AA 1JOMA 1MVSA 1OHJA 3QL3A 3QLSA 3NTZA 4M7VA 3FQFA 1DR6A 3NU0A 5HT5A 3S9UA 2XW7A 4XT7A 3SGYA 4DPHA 1HFRA 1KMSA 2HQPA 4QLFA 1JOLA 2BLCA 3KY8A 3SH2A 4HA9A 5HQYA 1DHJA 1RB2A 4KYAA
chains in the Genus database with same CATH topology
3K47A 5DXVA 3K45A 2C2SA 1RA3A 1DISA 3IA4A 2W3MA 2GD9A 4H98A 6DFRA 1RF7A 4FHBA 5HSUA 3TQ9A 3JWCA 1AI9A 4KM2A 3SR5X 1S3WA 5HI6A 1PD9A 1DR5A 3UM5A 2KGKA 4KLXA 3F0XX 4X5HA 3HBBA 3M09A 3ROAA 1S3YA 3QFXA 1OHKA 1DRFA 3I8AX 1RA2A 1DR2A 1DRBA 3EELA 1IA1A 3OAFA 4X5IA 1DR7A 3JSUA 5JA3A 3FY8X 2W9SA 2ZZAA 4OR7A 4DDRA 1DREA 5HVEA 4KJKA 3NXRA 1DF7A 2DRCA 3F0BX 3QLZA 4H96A 2G6VA 4KJLA 1DR1A 1RC4A 4ELBA 1RX7A 3SQYX 3IRMA 2BLAA 3CL9A 4X5JA 3NZBX 1DG8A 1RX9A 3NZCX 1M79A 2ITHA 1DLRA 1QZFA 1BZFA 1ZDRA 3JW5A 4P66A 3SRQX 2ANOA 3UM8A 3GI2A 1DRHA 5HUIA 2O7PA 3NZAX 1J3KA 2OIPA 3SA1A 4PSYA 2B3ZA 3RG9A 1DRAA 2W9TA 5JG0X 4HOGA 1U71A 2HM9A 1JUVA 4ELHA 5HF0X 1U70A 4XT4A 4P3RA 1SEJA 1S3VA 1LY3A 4LEKX 3NZDA 3GHWA 2FZJA 1PDBA 4QJZD 2ANQA 3L3RA 2W3AA 4KM0A 4M6LA 4GH8A 4PDJA 3JW3A 5U26A 3DG8A 2W3WA 4M6JA 3CLBA 3DRCA 1U72A 4OSGA 4HA7A 3FL9A 3VCOA 2CIGA 1S3UA 2D0KA 4H95A 1AOEA 1LY4A 4NX6A 3SA2A 3DATA 3F0UX 3N0HA 3DGAA 1BOZA 1DG5A 1RX5A 1TDRA 3DAUA 1DR4A 4ECKA 4P68A 1PD8A 1RX3A 3GHCA 3IX9A 1DAJA 3F0VX 2HXVA 3ZPCA 4HOEA 3JWMA 4Q0DA 4H97A 1CD2A 1M7AA 3SRRX 4KFJA 4DP3A 3EEMA 1RG7A 3IA5A 3Q1HA 3KGYA 3F91A 1E26A 3FY9X 3KJRA 4PTHA 4HOFA 1KMVA 5FDAA 2AZNA 2W9GA 1HFQA 1RB3A 3NXXA 4KY4A 4NX7A 4XECX 3DL6A 1DYRA 5EAJA 3INVA 3SRUX 1VDRA 3NXTA 4DFRA 3NZ9X 5HF2X 4QHVA 1RX4A 1D1GA 3FQVA 4Q0EA 5HT4A 2JYBA 3D84X 3ZPGA 4M7UA 3NRRA 4ELFA 1LUDA 3EEKA 4FGGA 4M6KA 3CD2A 4ELEA 3QL0A 4X5GA 1RD7A 1IA2A 4KY8A 2BL9A 3HJ3A 1DYHA 4LAEX 3OCHA 1RX2A 2D5NA 1RX6A 1CZ3A 7DFRA 3FRFX 4KJJA 3QG2A 3QLXA 2CD2A 3NXYA 4P3QA 2C2TA 3F0SX 4ELGA 5CCCA 3FQ0A 1VJ3A 4PTJA 4LAHX 3DL5A 1MVTA 3RO9A 2LF1A 1RE7A 3FRBX 4G95A 3FQCA 1J3IA 3SAIA 3K2HA 3KFYA 2INQA 3F8YA 4XT8A 3EX8A 1DIUA 3E0BA 3F0QX 3IRNA 4IXED 1IA3A 4XRBA 4CD2A 3NXOA 4XT5A 1DYJA 4M2XA 1RA8A 3FYWX 4PSTA 2W9HA 1KLKA 1IA4A 3QLYA 4Q67A 4EIGA 3JVXA 4TU5X 5HQZA 4Q6AA 3GYFA 4IXFX 5HSRA 3D80A 1RH3A 3TD8A 4G3MA 4I1NA 4FGHA 4XE6X 1DHIA 3S3VA 1DDRA 1M78A 5E8QA 4KBNA 2DHFA 3QYLA 4QI9A 4EJ1A 1RX8A 3SRWX 3TQAA 4QLEA 3NXVA 1AO8A 4KAKA 8DFRA 1HFPA 5CC9A 3JWFA 3TQ8A 3FYVX 4KL9A 2QK8A 4KEBA 2W3VA 3FQZA 4KD7A 3EEJA 1DYIA 1DDSA 4EIZA 3FRAX 4PSSA 3GHVA 1YHOA 1DHFA 3FRDX 5ECXA 3NZ6X 4IXGX 5U27A 3SRSX 4LAGX 3K74A 4QLGA 3F8ZA 2L28A 1DG7A 5HPBA 3JTWA 4KNEA 1RA9A 3CSEA 2OBCA 4QJCA 4RGCA 5DFRA 4XT6A 4I13A 3QYOA 4X5FA 3DFRA 3R33A 2P4GA 1DR3A 3LG4A 2FZHA 3QLRA 3JWKA 3FL8A 1DLSA 2FZIA 1RA1A 1RX1A 2W3BA 3I3RA 5HVBA 3FQOA 3QLWA 5ECCA 3FREX 3M08A 3UM6A 1J3JA 4G8ZX 3FS6A 2H2QA 3IROA 3TQBA 3QGTA 4EILA 4DPDA 3KJSA 3EIGA 2BLBA 3S7AA 1JOMA 1MVSA 1OHJA 3QL3A 3QLSA 3NTZA 4M7VA 3FQFA 1DR6A 3NU0A 5HT5A 3S9UA 2XW7A 4XT7A 3SGYA 4DPHA 1HFRA 1KMSA 2HQPA 4QLFA 1JOLA 2BLCA 3KY8A 3SH2A 4HA9A 5HQYA 1DHJA 1RB2A 4KYAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3K47 A;  5DXV A;  3K45 A;  2C2S A;  1RA3 A;  1DIS A;  3IA4 A;  2W3M A;  2GD9 A;  4H98 A;  6DFR A;  1RF7 A;  4FHB A;  5HSU A;  3TQ9 A;  3JWC A;  1AI9 A;  4KM2 A;  3SR5 X;  1S3W A;  5HI6 A;  1PD9 A;  1DR5 A;  3UM5 A;  2KGK A;  4KLX A;  3F0X X;  4X5H A;  3HBB A;  3M09 A;  3ROA A;  1S3Y A;  3QFX A;  1OHK A;  1DRF A;  3I8A X;  1RA2 A;  1DR2 A;  1DRB A;  3EEL A;  1IA1 A;  3OAF A;  4X5I A;  1DR7 A;  3JSU A;  5JA3 A;  3FY8 X;  2W9S A;  2ZZA A;  4OR7 A;  4DDR A;  1DRE A;  5HVE A;  4KJK A;  3NXR A;  1DF7 A;  2DRC A;  3F0B X;  3QLZ A;  4H96 A;  2G6V A;  4KJL A;  1DR1 A;  1RC4 A;  4ELB A;  1RX7 A;  3SQY X;  3IRM A;  2BLA A;  3CL9 A;  4X5J A;  3NZB X;  1DG8 A;  1RX9 A;  3NZC X;  1M79 A;  2ITH A;  1DLR A;  1QZF A;  1BZF A;  1ZDR A;  3JW5 A;  4P66 A;  3SRQ X;  2ANO A;  3UM8 A;  3GI2 A;  1DRH A;  5HUI A;  2O7P A;  3NZA X;  1J3K A;  2OIP A;  3SA1 A;  4PSY A;  2B3Z A;  3RG9 A;  1DRA A;  2W9T A;  5JG0 X;  4HOG A;  1U71 A;  2HM9 A;  1JUV A;  4ELH A;  5HF0 X;  1U70 A;  4XT4 A;  4P3R A;  1SEJ A;  1S3V A;  1LY3 A;  4LEK X;  3NZD A;  3GHW A;  2FZJ A;  1PDB A;  4QJZ D;  2ANQ A;  3L3R A;  2W3A A;  4KM0 A;  4M6L A;  4GH8 A;  4PDJ A;  3JW3 A;  5U26 A;  3DG8 A;  2W3W A;  4M6J A;  3CLB A;  3DRC A;  1U72 A;  4OSG A;  4HA7 A;  3FL9 A;  3VCO A;  2CIG A;  1S3U A;  2D0K A;  4H95 A;  1AOE A;  1LY4 A;  4NX6 A;  3SA2 A;  3DAT A;  3F0U X;  3N0H A;  3DGA A;  1BOZ A;  1DG5 A;  1RX5 A;  1TDR A;  3DAU A;  1DR4 A;  4ECK A;  4P68 A;  1PD8 A;  1RX3 A;  3GHC A;  3IX9 A;  1DAJ A;  3F0V X;  2HXV A;  3ZPC A;  4HOE A;  3JWM A;  4Q0D A;  4H97 A;  1CD2 A;  1M7A A;  3SRR X;  4KFJ A;  4DP3 A;  3EEM A;  1RG7 A;  3IA5 A;  3Q1H A;  3KGY A;  3F91 A;  1E26 A;  3FY9 X;  3KJR A;  4PTH A;  4HOF A;  1KMV A;  5FDA A;  2AZN A;  2W9G A;  1HFQ A;  1RB3 A;  3NXX A;  4KY4 A;  4NX7 A;  4XEC X;  3DL6 A;  1DYR A;  5EAJ A;  3INV A;  3SRU X;  1VDR A;  3NXT A;  4DFR A;  3NZ9 X;  5HF2 X;  4QHV A;  1RX4 A;  1D1G A;  3FQV A;  4Q0E A;  5HT4 A;  2JYB A;  3D84 X;  3ZPG A;  4M7U A;  3NRR A;  4ELF A;  1LUD A;  3EEK A;  4FGG A;  4M6K A;  3CD2 A;  4ELE A;  3QL0 A;  4X5G A;  1RD7 A;  1IA2 A;  4KY8 A;  2BL9 A;  3HJ3 A;  1DYH A;  4LAE X;  3OCH A;  1RX2 A;  2D5N A;  1RX6 A;  1CZ3 A;  7DFR A;  3FRF X;  4KJJ A;  3QG2 A;  3QLX A;  2CD2 A;  3NXY A;  4P3Q A;  2C2T A;  3F0S X;  4ELG A;  5CCC A;  3FQ0 A;  1VJ3 A;  4PTJ A;  4LAH X;  3DL5 A;  1MVT A;  3RO9 A;  2LF1 A;  1RE7 A;  3FRB X;  4G95 A;  3FQC A;  1J3I A;  3SAI A;  3K2H A;  3KFY A;  2INQ A;  3F8Y A;  4XT8 A;  3EX8 A;  1DIU A;  3E0B A;  3F0Q X;  3IRN A;  4IXE D;  1IA3 A;  4XRB A;  4CD2 A;  3NXO A;  4XT5 A;  1DYJ A;  4M2X A;  1RA8 A;  3FYW X;  4PST A;  2W9H A;  1KLK A;  1IA4 A;  3QLY A;  4Q67 A;  4EIG A;  3JVX A;  4TU5 X;  5HQZ A;  4Q6A A;  3GYF A;  4IXF X;  5HSR A;  3D80 A;  1RH3 A;  3TD8 A;  4G3M A;  4I1N A;  4FGH A;  4XE6 X;  1DHI A;  3S3V A;  1DDR A;  1M78 A;  5E8Q A;  4KBN A;  2DHF A;  3QYL A;  4QI9 A;  4EJ1 A;  1RX8 A;  3SRW X;  3TQA A;  4QLE A;  3NXV A;  1AO8 A;  4KAK A;  8DFR A;  1HFP A;  5CC9 A;  3JWF A;  3TQ8 A;  3FYV X;  4KL9 A;  2QK8 A;  4KEB A;  2W3V A;  3FQZ A;  4KD7 A;  3EEJ A;  1DYI A;  1DDS A;  4EIZ A;  3FRA X;  4PSS A;  3GHV A;  1YHO A;  1DHF A;  3FRD X;  5ECX A;  3NZ6 X;  4IXG X;  5U27 A;  3SRS X;  4LAG X;  3K74 A;  4QLG A;  3F8Z A;  2L28 A;  1DG7 A;  5HPB A;  3JTW A;  4KNE A;  1RA9 A;  3CSE A;  2OBC A;  4QJC A;  4RGC A;  5DFR A;  4XT6 A;  4I13 A;  3QYO A;  4X5F A;  3DFR A;  3R33 A;  2P4G A;  1DR3 A;  3LG4 A;  2FZH A;  3QLR A;  3JWK A;  3FL8 A;  1DLS A;  2FZI A;  1RA1 A;  1RX1 A;  2W3B A;  3I3R A;  5HVB A;  3FQO A;  3QLW A;  5ECC A;  3FRE X;  3M08 A;  3UM6 A;  1J3J A;  4G8Z X;  3FS6 A;  2H2Q A;  3IRO A;  3TQB A;  3QGT A;  4EIL A;  4DPD A;  3KJS A;  3EIG A;  2BLB A;  3S7A A;  1JOM A;  1MVS A;  1OHJ A;  3QL3 A;  3QLS A;  3NTZ A;  4M7V A;  3FQF A;  1DR6 A;  3NU0 A;  5HT5 A;  3S9U A;  2XW7 A;  4XT7 A;  3SGY A;  4DPH A;  1HFR A;  1KMS A;  2HQP A;  4QLF A;  1JOL A;  2BLC A;  3KY8 A;  3SH2 A;  4HA9 A;  5HQY A;  1DHJ A;  1RB2 A;  4KYA A; 
#chains in the Genus database with same CATH topology
 3K47 A;  5DXV A;  3K45 A;  2C2S A;  1RA3 A;  1DIS A;  3IA4 A;  2W3M A;  2GD9 A;  4H98 A;  6DFR A;  1RF7 A;  4FHB A;  5HSU A;  3TQ9 A;  3JWC A;  1AI9 A;  4KM2 A;  3SR5 X;  1S3W A;  5HI6 A;  1PD9 A;  1DR5 A;  3UM5 A;  2KGK A;  4KLX A;  3F0X X;  4X5H A;  3HBB A;  3M09 A;  3ROA A;  1S3Y A;  3QFX A;  1OHK A;  1DRF A;  3I8A X;  1RA2 A;  1DR2 A;  1DRB A;  3EEL A;  1IA1 A;  3OAF A;  4X5I A;  1DR7 A;  3JSU A;  5JA3 A;  3FY8 X;  2W9S A;  2ZZA A;  4OR7 A;  4DDR A;  1DRE A;  5HVE A;  4KJK A;  3NXR A;  1DF7 A;  2DRC A;  3F0B X;  3QLZ A;  4H96 A;  2G6V A;  4KJL A;  1DR1 A;  1RC4 A;  4ELB A;  1RX7 A;  3SQY X;  3IRM A;  2BLA A;  3CL9 A;  4X5J A;  3NZB X;  1DG8 A;  1RX9 A;  3NZC X;  1M79 A;  2ITH A;  1DLR A;  1QZF A;  1BZF A;  1ZDR A;  3JW5 A;  4P66 A;  3SRQ X;  2ANO A;  3UM8 A;  3GI2 A;  1DRH A;  5HUI A;  2O7P A;  3NZA X;  1J3K A;  2OIP A;  3SA1 A;  4PSY A;  2B3Z A;  3RG9 A;  1DRA A;  2W9T A;  5JG0 X;  4HOG A;  1U71 A;  2HM9 A;  1JUV A;  4ELH A;  5HF0 X;  1U70 A;  4XT4 A;  4P3R A;  1SEJ A;  1S3V A;  1LY3 A;  4LEK X;  3NZD A;  3GHW A;  2FZJ A;  1PDB A;  4QJZ D;  2ANQ A;  3L3R A;  2W3A A;  4KM0 A;  4M6L A;  4GH8 A;  4PDJ A;  3JW3 A;  5U26 A;  3DG8 A;  2W3W A;  4M6J A;  3CLB A;  3DRC A;  1U72 A;  4OSG A;  4HA7 A;  3FL9 A;  3VCO A;  2CIG A;  1S3U A;  2D0K A;  4H95 A;  1AOE A;  1LY4 A;  4NX6 A;  3SA2 A;  3DAT A;  3F0U X;  3N0H A;  3DGA A;  1BOZ A;  1DG5 A;  1RX5 A;  1TDR A;  3DAU A;  1DR4 A;  4ECK A;  4P68 A;  1PD8 A;  1RX3 A;  3GHC A;  3IX9 A;  1DAJ A;  3F0V X;  2HXV A;  3ZPC A;  4HOE A;  3JWM A;  4Q0D A;  4H97 A;  1CD2 A;  1M7A A;  3SRR X;  4KFJ A;  4DP3 A;  3EEM A;  1RG7 A;  3IA5 A;  3Q1H A;  3KGY A;  3F91 A;  1E26 A;  3FY9 X;  3KJR A;  4PTH A;  4HOF A;  1KMV A;  5FDA A;  2AZN A;  2W9G A;  1HFQ A;  1RB3 A;  3NXX A;  4KY4 A;  4NX7 A;  4XEC X;  3DL6 A;  1DYR A;  5EAJ A;  3INV A;  3SRU X;  1VDR A;  3NXT A;  4DFR A;  3NZ9 X;  5HF2 X;  4QHV A;  1RX4 A;  1D1G A;  3FQV A;  4Q0E A;  5HT4 A;  2JYB A;  3D84 X;  3ZPG A;  4M7U A;  3NRR A;  4ELF A;  1LUD A;  3EEK A;  4FGG A;  4M6K A;  3CD2 A;  4ELE A;  3QL0 A;  4X5G A;  1RD7 A;  1IA2 A;  4KY8 A;  2BL9 A;  3HJ3 A;  1DYH A;  4LAE X;  3OCH A;  1RX2 A;  2D5N A;  1RX6 A;  1CZ3 A;  7DFR A;  3FRF X;  4KJJ A;  3QG2 A;  3QLX A;  2CD2 A;  3NXY A;  4P3Q A;  2C2T A;  3F0S X;  4ELG A;  5CCC A;  3FQ0 A;  1VJ3 A;  4PTJ A;  4LAH X;  3DL5 A;  1MVT A;  3RO9 A;  2LF1 A;  1RE7 A;  3FRB X;  4G95 A;  3FQC A;  1J3I A;  3SAI A;  3K2H A;  3KFY A;  2INQ A;  3F8Y A;  4XT8 A;  3EX8 A;  1DIU A;  3E0B A;  3F0Q X;  3IRN A;  4IXE D;  1IA3 A;  4XRB A;  4CD2 A;  3NXO A;  4XT5 A;  1DYJ A;  4M2X A;  1RA8 A;  3FYW X;  4PST A;  2W9H A;  1KLK A;  1IA4 A;  3QLY A;  4Q67 A;  4EIG A;  3JVX A;  4TU5 X;  5HQZ A;  4Q6A A;  3GYF A;  4IXF X;  5HSR A;  3D80 A;  1RH3 A;  3TD8 A;  4G3M A;  4I1N A;  4FGH A;  4XE6 X;  1DHI A;  3S3V A;  1DDR A;  1M78 A;  5E8Q A;  4KBN A;  2DHF A;  3QYL A;  4QI9 A;  4EJ1 A;  1RX8 A;  3SRW X;  3TQA A;  4QLE A;  3NXV A;  1AO8 A;  4KAK A;  8DFR A;  1HFP A;  5CC9 A;  3JWF A;  3TQ8 A;  3FYV X;  4KL9 A;  2QK8 A;  4KEB A;  2W3V A;  3FQZ A;  4KD7 A;  3EEJ A;  1DYI A;  1DDS A;  4EIZ A;  3FRA X;  4PSS A;  3GHV A;  1YHO A;  1DHF A;  3FRD X;  5ECX A;  3NZ6 X;  4IXG X;  5U27 A;  3SRS X;  4LAG X;  3K74 A;  4QLG A;  3F8Z A;  2L28 A;  1DG7 A;  5HPB A;  3JTW A;  4KNE A;  1RA9 A;  3CSE A;  2OBC A;  4QJC A;  4RGC A;  5DFR A;  4XT6 A;  4I13 A;  3QYO A;  4X5F A;  3DFR A;  3R33 A;  2P4G A;  1DR3 A;  3LG4 A;  2FZH A;  3QLR A;  3JWK A;  3FL8 A;  1DLS A;  2FZI A;  1RA1 A;  1RX1 A;  2W3B A;  3I3R A;  5HVB A;  3FQO A;  3QLW A;  5ECC A;  3FRE X;  3M08 A;  3UM6 A;  1J3J A;  4G8Z X;  3FS6 A;  2H2Q A;  3IRO A;  3TQB A;  3QGT A;  4EIL A;  4DPD A;  3KJS A;  3EIG A;  2BLB A;  3S7A A;  1JOM A;  1MVS A;  1OHJ A;  3QL3 A;  3QLS A;  3NTZ A;  4M7V A;  3FQF A;  1DR6 A;  3NU0 A;  5HT5 A;  3S9U A;  2XW7 A;  4XT7 A;  3SGY A;  4DPH A;  1HFR A;  1KMS A;  2HQP A;  4QLF A;  1JOL A;  2BLC A;  3KY8 A;  3SH2 A;  4HA9 A;  5HQY A;  1DHJ A;  1RB2 A;  4KYA A; 
#chains in the Genus database with same CATH homology
 3K47 A;  5DXV A;  3K45 A;  2C2S A;  1RA3 A;  1DIS A;  3IA4 A;  2W3M A;  2GD9 A;  4H98 A;  6DFR A;  1RF7 A;  4FHB A;  5HSU A;  3TQ9 A;  3JWC A;  1AI9 A;  4KM2 A;  3SR5 X;  1S3W A;  5HI6 A;  1PD9 A;  1DR5 A;  3UM5 A;  2KGK A;  4KLX A;  3F0X X;  4X5H A;  3HBB A;  3M09 A;  3ROA A;  1S3Y A;  3QFX A;  1OHK A;  1DRF A;  3I8A X;  1RA2 A;  1DR2 A;  1DRB A;  3EEL A;  1IA1 A;  3OAF A;  4X5I A;  1DR7 A;  3JSU A;  5JA3 A;  3FY8 X;  2W9S A;  2ZZA A;  4OR7 A;  4DDR A;  1DRE A;  5HVE A;  4KJK A;  3NXR A;  1DF7 A;  2DRC A;  3F0B X;  3QLZ A;  4H96 A;  2G6V A;  4KJL A;  1DR1 A;  1RC4 A;  4ELB A;  1RX7 A;  3SQY X;  3IRM A;  2BLA A;  3CL9 A;  4X5J A;  3NZB X;  1DG8 A;  1RX9 A;  3NZC X;  1M79 A;  2ITH A;  1DLR A;  1QZF A;  1BZF A;  1ZDR A;  3JW5 A;  4P66 A;  3SRQ X;  2ANO A;  3UM8 A;  3GI2 A;  1DRH A;  5HUI A;  2O7P A;  3NZA X;  1J3K A;  2OIP A;  3SA1 A;  4PSY A;  2B3Z A;  3RG9 A;  1DRA A;  2W9T A;  5JG0 X;  4HOG A;  1U71 A;  2HM9 A;  1JUV A;  4ELH A;  5HF0 X;  1U70 A;  4XT4 A;  4P3R A;  1SEJ A;  1S3V A;  1LY3 A;  4LEK X;  3NZD A;  3GHW A;  2FZJ A;  1PDB A;  4QJZ D;  2ANQ A;  3L3R A;  2W3A A;  4KM0 A;  4M6L A;  4GH8 A;  4PDJ A;  3JW3 A;  5U26 A;  3DG8 A;  2W3W A;  4M6J A;  3CLB A;  3DRC A;  1U72 A;  4OSG A;  4HA7 A;  3FL9 A;  3VCO A;  2CIG A;  1S3U A;  2D0K A;  4H95 A;  1AOE A;  1LY4 A;  4NX6 A;  3SA2 A;  3DAT A;  3F0U X;  3N0H A;  3DGA A;  1BOZ A;  1DG5 A;  1RX5 A;  1TDR A;  3DAU A;  1DR4 A;  4ECK A;  4P68 A;  1PD8 A;  1RX3 A;  3GHC A;  3IX9 A;  1DAJ A;  3F0V X;  2HXV A;  3ZPC A;  4HOE A;  3JWM A;  4Q0D A;  4H97 A;  1CD2 A;  1M7A A;  3SRR X;  4KFJ A;  4DP3 A;  3EEM A;  1RG7 A;  3IA5 A;  3Q1H A;  3KGY A;  3F91 A;  1E26 A;  3FY9 X;  3KJR A;  4PTH A;  4HOF A;  1KMV A;  5FDA A;  2AZN A;  2W9G A;  1HFQ A;  1RB3 A;  3NXX A;  4KY4 A;  4NX7 A;  4XEC X;  3DL6 A;  1DYR A;  5EAJ A;  3INV A;  3SRU X;  1VDR A;  3NXT A;  4DFR A;  3NZ9 X;  5HF2 X;  4QHV A;  1RX4 A;  1D1G A;  3FQV A;  4Q0E A;  5HT4 A;  2JYB A;  3D84 X;  3ZPG A;  4M7U A;  3NRR A;  4ELF A;  1LUD A;  3EEK A;  4FGG A;  4M6K A;  3CD2 A;  4ELE A;  3QL0 A;  4X5G A;  1RD7 A;  1IA2 A;  4KY8 A;  2BL9 A;  3HJ3 A;  1DYH A;  4LAE X;  3OCH A;  1RX2 A;  2D5N A;  1RX6 A;  1CZ3 A;  7DFR A;  3FRF X;  4KJJ A;  3QG2 A;  3QLX A;  2CD2 A;  3NXY A;  4P3Q A;  2C2T A;  3F0S X;  4ELG A;  5CCC A;  3FQ0 A;  1VJ3 A;  4PTJ A;  4LAH X;  3DL5 A;  1MVT A;  3RO9 A;  2LF1 A;  1RE7 A;  3FRB X;  4G95 A;  3FQC A;  1J3I A;  3SAI A;  3K2H A;  3KFY A;  2INQ A;  3F8Y A;  4XT8 A;  3EX8 A;  1DIU A;  3E0B A;  3F0Q X;  3IRN A;  4IXE D;  1IA3 A;  4XRB A;  4CD2 A;  3NXO A;  4XT5 A;  1DYJ A;  4M2X A;  1RA8 A;  3FYW X;  4PST A;  2W9H A;  1KLK A;  1IA4 A;  3QLY A;  4Q67 A;  4EIG A;  3JVX A;  4TU5 X;  5HQZ A;  4Q6A A;  3GYF A;  4IXF X;  5HSR A;  3D80 A;  1RH3 A;  3TD8 A;  4G3M A;  4I1N A;  4FGH A;  4XE6 X;  1DHI A;  3S3V A;  1DDR A;  1M78 A;  5E8Q A;  4KBN A;  2DHF A;  3QYL A;  4QI9 A;  4EJ1 A;  1RX8 A;  3SRW X;  3TQA A;  4QLE A;  3NXV A;  1AO8 A;  4KAK A;  8DFR A;  1HFP A;  5CC9 A;  3JWF A;  3TQ8 A;  3FYV X;  4KL9 A;  2QK8 A;  4KEB A;  2W3V A;  3FQZ A;  4KD7 A;  3EEJ A;  1DYI A;  1DDS A;  4EIZ A;  3FRA X;  4PSS A;  3GHV A;  1YHO A;  1DHF A;  3FRD X;  5ECX A;  3NZ6 X;  4IXG X;  5U27 A;  3SRS X;  4LAG X;  3K74 A;  4QLG A;  3F8Z A;  2L28 A;  1DG7 A;  5HPB A;  3JTW A;  4KNE A;  1RA9 A;  3CSE A;  2OBC A;  4QJC A;  4RGC A;  5DFR A;  4XT6 A;  4I13 A;  3QYO A;  4X5F A;  3DFR A;  3R33 A;  2P4G A;  1DR3 A;  3LG4 A;  2FZH A;  3QLR A;  3JWK A;  3FL8 A;  1DLS A;  2FZI A;  1RA1 A;  1RX1 A;  2W3B A;  3I3R A;  5HVB A;  3FQO A;  3QLW A;  5ECC A;  3FRE X;  3M08 A;  3UM6 A;  1J3J A;  4G8Z X;  3FS6 A;  2H2Q A;  3IRO A;  3TQB A;  3QGT A;  4EIL A;  4DPD A;  3KJS A;  3EIG A;  2BLB A;  3S7A A;  1JOM A;  1MVS A;  1OHJ A;  3QL3 A;  3QLS A;  3NTZ A;  4M7V A;  3FQF A;  1DR6 A;  3NU0 A;  5HT5 A;  3S9U A;  2XW7 A;  4XT7 A;  3SGY A;  4DPH A;  1HFR A;  1KMS A;  2HQP A;  4QLF A;  1JOL A;  2BLC A;  3KY8 A;  3SH2 A;  4HA9 A;  5HQY A;  1DHJ A;  1RB2 A;  4KYA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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