4OSGA

Klebsiella pneumoniae complexed with nadph and 6-ethyl-5-[(3r)-3-[3-methoxyl-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (ucp1006)
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNIVISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Klebsiella pneumoniae cg43
molecule keywords Dihydrofolate reductase
total genus 38
structure length 159
sequence length 159
chains with identical sequence B, C, D
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2014-02-12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4osgA00
4M7VA 3M09A 1RX4A 5U26A 3F0BX 1RX2A 1U70A 5E8QA 3K2HA 2W9SA 1S3UA 3SRSX 3CLBA 4QJCA 5HSRA 3F0QX 4OSGA 3F91A 1AI9A 1DAJA 4Q6AA 3VCOA 1VDRA 1RD7A 3QG2A 1DREA 3Q1HA 4X5GA 4M7UA 4LAGX 3DFRA 2W3WA 1KMSA 4KBNA 1RX8A 2W9GA 1DG5A 3EEKA 3FL9A 3UM5A 3INVA 4ELHA 2DRCA 3QLXA 3SA1A 3NTZA 4KAKA 3F0XX 3SAIA 1DG8A 2HQPA 4FHBA 2ITHA 4PTJA 3ROAA 3E0BA 3FRDX 4G3MA 3KJRA 1PD8A 5HF2X 1IA2A 3GHCA 2BLBA 4M6LA 3I3RA 1HFPA 1IA4A 3JW3A 1RA2A 3I8AX 3FQZA 3FQ0A 2GD9A 5JA3A 2B3ZA 2BLCA 3M08A 1M78A 5HF0X 1E26A 4KY8A 3SGYA 3JW5A 1DR4A 2W3BA 4DFRA 1IA3A 3K74A 1IA1A 3JVXA 4Q0EA 2W3VA 3FREX 1KLKA 3FRBX 1AOEA 3TQBA 3S9UA 4LEKX 1DG7A 4FGGA 4XRBA 1DIUA 5HSUA 1HFRA 4M6KA 1DR3A 4XT8A 5FDAA 3UM6A 1CD2A 3EEJA 5U27A 4H97A 1M79A 4KFJA 3SRUX 5HVEA 1RA3A 1DYIA 5HI6A 2FZHA 1DR6A 5HQZA 3KY8A 4LAHX 1RX6A 3FYVX 1MVTA 4IXGX 3NZCX 1JUVA 2CIGA 3QYOA 3FRAX 4KD7A 3FRFX 3FS6A 4NX6A 3QGTA 4QLEA 4ELFA 3LG4A 4XT6A 4X5HA 1JOMA 3OCHA 2ANQA 4QLGA 3QFXA 1RF7A 3KJSA 3QL0A 4KLXA 2D0KA 1DHIA 4XT7A 3QL3A 1QZFA 4DP3A 4P3QA 1AO8A 1RA9A 5ECXA 3NZ9X 1DRFA 3F0UX 4KNEA 1DR5A 3TQAA 3NXTA 4QLFA 4PTHA 3DG8A 5JG0X 1RA1A 3QLYA 2OIPA 1RC4A 2INQA 4I13A 4QJZD 3NXOA 3GI2A 2DHFA 3FY8X 3GHVA 1SEJA 4XT4A 3FQFA 4XE6X 1RX7A 1RX5A 3JWFA 3K47A 5HT4A 1U72A 3EELA 4NX7A 4KEBA 3IRNA 4PSTA 3N0HA 2BLAA 3F0SX 3RO9A 2QK8A 1S3WA 1RH3A 5CCCA 5CC9A 1DR7A 3K45A 4CD2A 3FL8A 3TD8A 2C2TA 3NXXA 3ZPCA 5HVBA 3CD2A 3SRRX 2W9HA 4PSSA 1VJ3A 4X5IA 4M6JA 3NXVA 2W3MA 3HBBA 4KM0A 3DAUA 2O7PA 5HPBA 4HOFA 3GYFA 3OAFA 1DLRA 1DR2A 3JTWA 4I1NA 3EEMA 3JWKA 3NXRA 2W9TA 5EAJA 6DFRA 3SA2A 4EIZA 4EJ1A 2OBCA 2ZZAA 4KYAA 1S3YA 5DFRA 5DXVA 1J3JA 3F8YA 1HFQA 1DRHA 1LUDA 2P4GA 3CL9A 1RX1A 1S3VA 3NZDA 5ECCA 1CZ3A 1J3KA 4Q67A 4H96A 4EIGA 1MVSA 3F8ZA 3FYWX 4H98A 3GHWA 1RX9A 1DISA 2C2SA 4DPHA 3EX8A 5HQYA 3HJ3A 3IX9A 4ELGA 1U71A 3S3VA 1RB2A 3DATA 3FY9X 3SR5X 2HM9A 3L3RA 1DHJA 3QLSA 4QI9A 3CSEA 1BZFA 3IROA 1DYHA 1PDBA 5HUIA 1RG7A 4P3RA 1DRAA 3F0VX 4X5JA 4KJJA 4X5FA 4DDRA 3QYLA 4DPDA 1RA8A 3NZ6X 4ECKA 3IRMA 3IA5A 1DLSA 3FQOA 4XECX 3KGYA 1DRBA 1DHFA 2HXVA 3IA4A 4PDJA 2FZJA 4HOGA 4QHVA 4FGHA 1DDRA 4RGCA 2H2QA 2L28A 4HOEA 1BOZA 4TU5X 2W3AA 1YHOA 1JOLA 4EILA 4M2XA 4H95A 1D1GA 4P66A 3FQVA 7DFRA 3JWMA 3TQ8A 3TQ9A 3SRWX 5HT5A 1DR1A 4G95A 4ELBA 2CD2A 3NU0A 2ANOA 4KJKA 3DGAA 3DL5A 1RX3A 4KL9A 1LY3A 3NZAX 3FQCA 4KM2A 1TDRA 1LY4A 3QLWA 3S7AA 1ZDRA 1DF7A 2AZNA 3SRQX 4HA7A 1J3IA 2G6VA 4ELEA 1PD9A 3DL6A 2BL9A 3ZPGA 3QLRA 3EIGA 3NRRA 3NZBX 4OR7A 4KJLA 1KMVA 4GH8A 2FZIA 3DRCA 4KY4A 3RG9A 3D84X 4IXED 3UM8A 1M7AA 3JWCA 3NXYA 4XT5A 2XW7A 3R33A 4LAEX 4PSYA 1DYRA 1RB3A 3SH2A 1RE7A 1DYJA 8DFRA 4G8ZX 2D5NA 2LF1A 1OHJA 4Q0DA 3SQYX 3D80A 3JSUA 3QLZA 3KFYA 4IXFX 2KGKA 2JYBA 1OHKA 4P68A 1DDSA 4HA9A
chains in the Genus database with same CATH superfamily
4M7VA 3M09A 1RX4A 5U26A 3F0BX 1RX2A 1U70A 5E8QA 3K2HA 2W9SA 1S3UA 3SRSX 3CLBA 4QJCA 5HSRA 3F0QX 4OSGA 3F91A 1AI9A 1DAJA 4Q6AA 3VCOA 1VDRA 1RD7A 3QG2A 1DREA 3Q1HA 4X5GA 4M7UA 4LAGX 3DFRA 2W3WA 1KMSA 4KBNA 1RX8A 2W9GA 1DG5A 3EEKA 3FL9A 3UM5A 3INVA 4ELHA 2DRCA 3QLXA 3SA1A 3NTZA 4KAKA 3F0XX 3SAIA 1DG8A 2HQPA 4FHBA 2ITHA 4PTJA 3ROAA 3E0BA 3FRDX 4G3MA 3KJRA 1PD8A 5HF2X 1IA2A 3GHCA 2BLBA 4M6LA 3I3RA 1HFPA 1IA4A 3JW3A 1RA2A 3I8AX 3FQZA 3FQ0A 2GD9A 5JA3A 2B3ZA 2BLCA 3M08A 1M78A 5HF0X 1E26A 4KY8A 3SGYA 3JW5A 1DR4A 2W3BA 4DFRA 1IA3A 3K74A 1IA1A 3JVXA 4Q0EA 2W3VA 3FREX 1KLKA 3FRBX 1AOEA 3TQBA 3S9UA 4LEKX 1DG7A 4FGGA 4XRBA 1DIUA 5HSUA 1HFRA 4M6KA 1DR3A 4XT8A 5FDAA 3UM6A 1CD2A 3EEJA 5U27A 4H97A 1M79A 4KFJA 3SRUX 5HVEA 1RA3A 1DYIA 5HI6A 2FZHA 1DR6A 5HQZA 3KY8A 4LAHX 1RX6A 3FYVX 1MVTA 4IXGX 3NZCX 1JUVA 2CIGA 3QYOA 3FRAX 4KD7A 3FRFX 3FS6A 4NX6A 3QGTA 4QLEA 4ELFA 3LG4A 4XT6A 4X5HA 1JOMA 3OCHA 2ANQA 4QLGA 3QFXA 1RF7A 3KJSA 3QL0A 4KLXA 2D0KA 1DHIA 4XT7A 3QL3A 1QZFA 4DP3A 4P3QA 1AO8A 1RA9A 5ECXA 3NZ9X 1DRFA 3F0UX 4KNEA 1DR5A 3TQAA 3NXTA 4QLFA 4PTHA 3DG8A 5JG0X 1RA1A 3QLYA 2OIPA 1RC4A 2INQA 4I13A 4QJZD 3NXOA 3GI2A 2DHFA 3FY8X 3GHVA 1SEJA 4XT4A 3FQFA 4XE6X 1RX7A 1RX5A 3JWFA 3K47A 5HT4A 1U72A 3EELA 4NX7A 4KEBA 3IRNA 4PSTA 3N0HA 2BLAA 3F0SX 3RO9A 2QK8A 1S3WA 1RH3A 5CCCA 5CC9A 1DR7A 3K45A 4CD2A 3FL8A 3TD8A 2C2TA 3NXXA 3ZPCA 5HVBA 3CD2A 3SRRX 2W9HA 4PSSA 1VJ3A 4X5IA 4M6JA 3NXVA 2W3MA 3HBBA 4KM0A 3DAUA 2O7PA 5HPBA 4HOFA 3GYFA 3OAFA 1DLRA 1DR2A 3JTWA 4I1NA 3EEMA 3JWKA 3NXRA 2W9TA 5EAJA 6DFRA 3SA2A 4EIZA 4EJ1A 2OBCA 2ZZAA 4KYAA 1S3YA 5DFRA 5DXVA 1J3JA 3F8YA 1HFQA 1DRHA 1LUDA 2P4GA 3CL9A 1RX1A 1S3VA 3NZDA 5ECCA 1CZ3A 1J3KA 4Q67A 4H96A 4EIGA 1MVSA 3F8ZA 3FYWX 4H98A 3GHWA 1RX9A 1DISA 2C2SA 4DPHA 3EX8A 5HQYA 3HJ3A 3IX9A 4ELGA 1U71A 3S3VA 1RB2A 3DATA 3FY9X 3SR5X 2HM9A 3L3RA 1DHJA 3QLSA 4QI9A 3CSEA 1BZFA 3IROA 1DYHA 1PDBA 5HUIA 1RG7A 4P3RA 1DRAA 3F0VX 4X5JA 4KJJA 4X5FA 4DDRA 3QYLA 4DPDA 1RA8A 3NZ6X 4ECKA 3IRMA 3IA5A 1DLSA 3FQOA 4XECX 3KGYA 1DRBA 1DHFA 2HXVA 3IA4A 4PDJA 2FZJA 4HOGA 4QHVA 4FGHA 1DDRA 4RGCA 2H2QA 2L28A 4HOEA 1BOZA 4TU5X 2W3AA 1YHOA 1JOLA 4EILA 4M2XA 4H95A 1D1GA 4P66A 3FQVA 7DFRA 3JWMA 3TQ8A 3TQ9A 3SRWX 5HT5A 1DR1A 4G95A 4ELBA 2CD2A 3NU0A 2ANOA 4KJKA 3DGAA 3DL5A 1RX3A 4KL9A 1LY3A 3NZAX 3FQCA 4KM2A 1TDRA 1LY4A 3QLWA 3S7AA 1ZDRA 1DF7A 2AZNA 3SRQX 4HA7A 1J3IA 2G6VA 4ELEA 1PD9A 3DL6A 2BL9A 3ZPGA 3QLRA 3EIGA 3NRRA 3NZBX 4OR7A 4KJLA 1KMVA 4GH8A 2FZIA 3DRCA 4KY4A 3RG9A 3D84X 4IXED 3UM8A 1M7AA 3JWCA 3NXYA 4XT5A 2XW7A 3R33A 4LAEX 4PSYA 1DYRA 1RB3A 3SH2A 1RE7A 1DYJA 8DFRA 4G8ZX 2D5NA 2LF1A 1OHJA 4Q0DA 3SQYX 3D80A 3JSUA 3QLZA 3KFYA 4IXFX 2KGKA 2JYBA 1OHKA 4P68A 1DDSA 4HA9A
chains in the Genus database with same CATH topology
4M7VA 3M09A 1RX4A 5U26A 3F0BX 1RX2A 1U70A 5E8QA 3K2HA 2W9SA 1S3UA 3SRSX 3CLBA 4QJCA 5HSRA 3F0QX 4OSGA 3F91A 1AI9A 1DAJA 4Q6AA 3VCOA 1VDRA 1RD7A 3QG2A 1DREA 3Q1HA 4X5GA 4M7UA 4LAGX 3DFRA 2W3WA 1KMSA 4KBNA 1RX8A 2W9GA 1DG5A 3EEKA 3FL9A 3UM5A 3INVA 4ELHA 2DRCA 3QLXA 3SA1A 3NTZA 4KAKA 3F0XX 3SAIA 1DG8A 2HQPA 4FHBA 2ITHA 4PTJA 3ROAA 3E0BA 3FRDX 4G3MA 3KJRA 1PD8A 5HF2X 1IA2A 3GHCA 2BLBA 4M6LA 3I3RA 1HFPA 1IA4A 3JW3A 1RA2A 3I8AX 3FQZA 3FQ0A 2GD9A 5JA3A 2B3ZA 2BLCA 3M08A 1M78A 5HF0X 1E26A 4KY8A 3SGYA 3JW5A 1DR4A 2W3BA 4DFRA 1IA3A 3K74A 1IA1A 3JVXA 4Q0EA 2W3VA 3FREX 1KLKA 3FRBX 1AOEA 3TQBA 3S9UA 4LEKX 1DG7A 4FGGA 4XRBA 1DIUA 5HSUA 1HFRA 4M6KA 1DR3A 4XT8A 5FDAA 3UM6A 1CD2A 3EEJA 5U27A 4H97A 1M79A 4KFJA 3SRUX 5HVEA 1RA3A 1DYIA 5HI6A 2FZHA 1DR6A 5HQZA 3KY8A 4LAHX 1RX6A 3FYVX 1MVTA 4IXGX 3NZCX 1JUVA 2CIGA 3QYOA 3FRAX 4KD7A 3FRFX 3FS6A 4NX6A 3QGTA 4QLEA 4ELFA 3LG4A 4XT6A 4X5HA 1JOMA 3OCHA 2ANQA 4QLGA 3QFXA 1RF7A 3KJSA 3QL0A 4KLXA 2D0KA 1DHIA 4XT7A 3QL3A 1QZFA 4DP3A 4P3QA 1AO8A 1RA9A 5ECXA 3NZ9X 1DRFA 3F0UX 4KNEA 1DR5A 3TQAA 3NXTA 4QLFA 4PTHA 3DG8A 5JG0X 1RA1A 3QLYA 2OIPA 1RC4A 2INQA 4I13A 4QJZD 3NXOA 3GI2A 2DHFA 3FY8X 3GHVA 1SEJA 4XT4A 3FQFA 4XE6X 1RX7A 1RX5A 3JWFA 3K47A 5HT4A 1U72A 3EELA 4NX7A 4KEBA 3IRNA 4PSTA 3N0HA 2BLAA 3F0SX 3RO9A 2QK8A 1S3WA 1RH3A 5CCCA 5CC9A 1DR7A 3K45A 4CD2A 3FL8A 3TD8A 2C2TA 3NXXA 3ZPCA 5HVBA 3CD2A 3SRRX 2W9HA 4PSSA 1VJ3A 4X5IA 4M6JA 3NXVA 2W3MA 3HBBA 4KM0A 3DAUA 2O7PA 5HPBA 4HOFA 3GYFA 3OAFA 1DLRA 1DR2A 3JTWA 4I1NA 3EEMA 3JWKA 3NXRA 2W9TA 5EAJA 6DFRA 3SA2A 4EIZA 4EJ1A 2OBCA 2ZZAA 4KYAA 1S3YA 5DFRA 5DXVA 1J3JA 3F8YA 1HFQA 1DRHA 1LUDA 2P4GA 3CL9A 1RX1A 1S3VA 3NZDA 5ECCA 1CZ3A 1J3KA 4Q67A 4H96A 4EIGA 1MVSA 3F8ZA 3FYWX 4H98A 3GHWA 1RX9A 1DISA 2C2SA 4DPHA 3EX8A 5HQYA 3HJ3A 3IX9A 4ELGA 1U71A 3S3VA 1RB2A 3DATA 3FY9X 3SR5X 2HM9A 3L3RA 1DHJA 3QLSA 4QI9A 3CSEA 1BZFA 3IROA 1DYHA 1PDBA 5HUIA 1RG7A 4P3RA 1DRAA 3F0VX 4X5JA 4KJJA 4X5FA 4DDRA 3QYLA 4DPDA 1RA8A 3NZ6X 4ECKA 3IRMA 3IA5A 1DLSA 3FQOA 4XECX 3KGYA 1DRBA 1DHFA 2HXVA 3IA4A 4PDJA 2FZJA 4HOGA 4QHVA 4FGHA 1DDRA 4RGCA 2H2QA 2L28A 4HOEA 1BOZA 4TU5X 2W3AA 1YHOA 1JOLA 4EILA 4M2XA 4H95A 1D1GA 4P66A 3FQVA 7DFRA 3JWMA 3TQ8A 3TQ9A 3SRWX 5HT5A 1DR1A 4G95A 4ELBA 2CD2A 3NU0A 2ANOA 4KJKA 3DGAA 3DL5A 1RX3A 4KL9A 1LY3A 3NZAX 3FQCA 4KM2A 1TDRA 1LY4A 3QLWA 3S7AA 1ZDRA 1DF7A 2AZNA 3SRQX 4HA7A 1J3IA 2G6VA 4ELEA 1PD9A 3DL6A 2BL9A 3ZPGA 3QLRA 3EIGA 3NRRA 3NZBX 4OR7A 4KJLA 1KMVA 4GH8A 2FZIA 3DRCA 4KY4A 3RG9A 3D84X 4IXED 3UM8A 1M7AA 3JWCA 3NXYA 4XT5A 2XW7A 3R33A 4LAEX 4PSYA 1DYRA 1RB3A 3SH2A 1RE7A 1DYJA 8DFRA 4G8ZX 2D5NA 2LF1A 1OHJA 4Q0DA 3SQYX 3D80A 3JSUA 3QLZA 3KFYA 4IXFX 2KGKA 2JYBA 1OHKA 4P68A 1DDSA 4HA9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4M7V A;  3M09 A;  1RX4 A;  5U26 A;  3F0B X;  1RX2 A;  1U70 A;  5E8Q A;  3K2H A;  2W9S A;  1S3U A;  3SRS X;  3CLB A;  4QJC A;  5HSR A;  3F0Q X;  4OSG A;  3F91 A;  1AI9 A;  1DAJ A;  4Q6A A;  3VCO A;  1VDR A;  1RD7 A;  3QG2 A;  1DRE A;  3Q1H A;  4X5G A;  4M7U A;  4LAG X;  3DFR A;  2W3W A;  1KMS A;  4KBN A;  1RX8 A;  2W9G A;  1DG5 A;  3EEK A;  3FL9 A;  3UM5 A;  3INV A;  4ELH A;  2DRC A;  3QLX A;  3SA1 A;  3NTZ A;  4KAK A;  3F0X X;  3SAI A;  1DG8 A;  2HQP A;  4FHB A;  2ITH A;  4PTJ A;  3ROA A;  3E0B A;  3FRD X;  4G3M A;  3KJR A;  1PD8 A;  5HF2 X;  1IA2 A;  3GHC A;  2BLB A;  4M6L A;  3I3R A;  1HFP A;  1IA4 A;  3JW3 A;  1RA2 A;  3I8A X;  3FQZ A;  3FQ0 A;  2GD9 A;  5JA3 A;  2B3Z A;  2BLC A;  3M08 A;  1M78 A;  5HF0 X;  1E26 A;  4KY8 A;  3SGY A;  3JW5 A;  1DR4 A;  2W3B A;  4DFR A;  1IA3 A;  3K74 A;  1IA1 A;  3JVX A;  4Q0E A;  2W3V A;  3FRE X;  1KLK A;  3FRB X;  1AOE A;  3TQB A;  3S9U A;  4LEK X;  1DG7 A;  4FGG A;  4XRB A;  1DIU A;  5HSU A;  1HFR A;  4M6K A;  1DR3 A;  4XT8 A;  5FDA A;  3UM6 A;  1CD2 A;  3EEJ A;  5U27 A;  4H97 A;  1M79 A;  4KFJ A;  3SRU X;  5HVE A;  1RA3 A;  1DYI A;  5HI6 A;  2FZH A;  1DR6 A;  5HQZ A;  3KY8 A;  4LAH X;  1RX6 A;  3FYV X;  1MVT A;  4IXG X;  3NZC X;  1JUV A;  2CIG A;  3QYO A;  3FRA X;  4KD7 A;  3FRF X;  3FS6 A;  4NX6 A;  3QGT A;  4QLE A;  4ELF A;  3LG4 A;  4XT6 A;  4X5H A;  1JOM A;  3OCH A;  2ANQ A;  4QLG A;  3QFX A;  1RF7 A;  3KJS A;  3QL0 A;  4KLX A;  2D0K A;  1DHI A;  4XT7 A;  3QL3 A;  1QZF A;  4DP3 A;  4P3Q A;  1AO8 A;  1RA9 A;  5ECX A;  3NZ9 X;  1DRF A;  3F0U X;  4KNE A;  1DR5 A;  3TQA A;  3NXT A;  4QLF A;  4PTH A;  3DG8 A;  5JG0 X;  1RA1 A;  3QLY A;  2OIP A;  1RC4 A;  2INQ A;  4I13 A;  4QJZ D;  3NXO A;  3GI2 A;  2DHF A;  3FY8 X;  3GHV A;  1SEJ A;  4XT4 A;  3FQF A;  4XE6 X;  1RX7 A;  1RX5 A;  3JWF A;  3K47 A;  5HT4 A;  1U72 A;  3EEL A;  4NX7 A;  4KEB A;  3IRN A;  4PST A;  3N0H A;  2BLA A;  3F0S X;  3RO9 A;  2QK8 A;  1S3W A;  1RH3 A;  5CCC A;  5CC9 A;  1DR7 A;  3K45 A;  4CD2 A;  3FL8 A;  3TD8 A;  2C2T A;  3NXX A;  3ZPC A;  5HVB A;  3CD2 A;  3SRR X;  2W9H A;  4PSS A;  1VJ3 A;  4X5I A;  4M6J A;  3NXV A;  2W3M A;  3HBB A;  4KM0 A;  3DAU A;  2O7P A;  5HPB A;  4HOF A;  3GYF A;  3OAF A;  1DLR A;  1DR2 A;  3JTW A;  4I1N A;  3EEM A;  3JWK A;  3NXR A;  2W9T A;  5EAJ A;  6DFR A;  3SA2 A;  4EIZ A;  4EJ1 A;  2OBC A;  2ZZA A;  4KYA A;  1S3Y A;  5DFR A;  5DXV A;  1J3J A;  3F8Y A;  1HFQ A;  1DRH A;  1LUD A;  2P4G A;  3CL9 A;  1RX1 A;  1S3V A;  3NZD A;  5ECC A;  1CZ3 A;  1J3K A;  4Q67 A;  4H96 A;  4EIG A;  1MVS A;  3F8Z A;  3FYW X;  4H98 A;  3GHW A;  1RX9 A;  1DIS A;  2C2S A;  4DPH A;  3EX8 A;  5HQY A;  3HJ3 A;  3IX9 A;  4ELG A;  1U71 A;  3S3V A;  1RB2 A;  3DAT A;  3FY9 X;  3SR5 X;  2HM9 A;  3L3R A;  1DHJ A;  3QLS A;  4QI9 A;  3CSE A;  1BZF A;  3IRO A;  1DYH A;  1PDB A;  5HUI A;  1RG7 A;  4P3R A;  1DRA A;  3F0V X;  4X5J A;  4KJJ A;  4X5F A;  4DDR A;  3QYL A;  4DPD A;  1RA8 A;  3NZ6 X;  4ECK A;  3IRM A;  3IA5 A;  1DLS A;  3FQO A;  4XEC X;  3KGY A;  1DRB A;  1DHF A;  2HXV A;  3IA4 A;  4PDJ A;  2FZJ A;  4HOG A;  4QHV A;  4FGH A;  1DDR A;  4RGC A;  2H2Q A;  2L28 A;  4HOE A;  1BOZ A;  4TU5 X;  2W3A A;  1YHO A;  1JOL A;  4EIL A;  4M2X A;  4H95 A;  1D1G A;  4P66 A;  3FQV A;  7DFR A;  3JWM A;  3TQ8 A;  3TQ9 A;  3SRW X;  5HT5 A;  1DR1 A;  4G95 A;  4ELB A;  2CD2 A;  3NU0 A;  2ANO A;  4KJK A;  3DGA A;  3DL5 A;  1RX3 A;  4KL9 A;  1LY3 A;  3NZA X;  3FQC A;  4KM2 A;  1TDR A;  1LY4 A;  3QLW A;  3S7A A;  1ZDR A;  1DF7 A;  2AZN A;  3SRQ X;  4HA7 A;  1J3I A;  2G6V A;  4ELE A;  1PD9 A;  3DL6 A;  2BL9 A;  3ZPG A;  3QLR A;  3EIG A;  3NRR A;  3NZB X;  4OR7 A;  4KJL A;  1KMV A;  4GH8 A;  2FZI A;  3DRC A;  4KY4 A;  3RG9 A;  3D84 X;  4IXE D;  3UM8 A;  1M7A A;  3JWC A;  3NXY A;  4XT5 A;  2XW7 A;  3R33 A;  4LAE X;  4PSY A;  1DYR A;  1RB3 A;  3SH2 A;  1RE7 A;  1DYJ A;  8DFR A;  4G8Z X;  2D5N A;  2LF1 A;  1OHJ A;  4Q0D A;  3SQY X;  3D80 A;  3JSU A;  3QLZ A;  3KFY A;  4IXF X;  2KGK A;  2JYB A;  1OHK A;  4P68 A;  1DDS A;  4HA9 A; 
#chains in the Genus database with same CATH topology
 4M7V A;  3M09 A;  1RX4 A;  5U26 A;  3F0B X;  1RX2 A;  1U70 A;  5E8Q A;  3K2H A;  2W9S A;  1S3U A;  3SRS X;  3CLB A;  4QJC A;  5HSR A;  3F0Q X;  4OSG A;  3F91 A;  1AI9 A;  1DAJ A;  4Q6A A;  3VCO A;  1VDR A;  1RD7 A;  3QG2 A;  1DRE A;  3Q1H A;  4X5G A;  4M7U A;  4LAG X;  3DFR A;  2W3W A;  1KMS A;  4KBN A;  1RX8 A;  2W9G A;  1DG5 A;  3EEK A;  3FL9 A;  3UM5 A;  3INV A;  4ELH A;  2DRC A;  3QLX A;  3SA1 A;  3NTZ A;  4KAK A;  3F0X X;  3SAI A;  1DG8 A;  2HQP A;  4FHB A;  2ITH A;  4PTJ A;  3ROA A;  3E0B A;  3FRD X;  4G3M A;  3KJR A;  1PD8 A;  5HF2 X;  1IA2 A;  3GHC A;  2BLB A;  4M6L A;  3I3R A;  1HFP A;  1IA4 A;  3JW3 A;  1RA2 A;  3I8A X;  3FQZ A;  3FQ0 A;  2GD9 A;  5JA3 A;  2B3Z A;  2BLC A;  3M08 A;  1M78 A;  5HF0 X;  1E26 A;  4KY8 A;  3SGY A;  3JW5 A;  1DR4 A;  2W3B A;  4DFR A;  1IA3 A;  3K74 A;  1IA1 A;  3JVX A;  4Q0E A;  2W3V A;  3FRE X;  1KLK A;  3FRB X;  1AOE A;  3TQB A;  3S9U A;  4LEK X;  1DG7 A;  4FGG A;  4XRB A;  1DIU A;  5HSU A;  1HFR A;  4M6K A;  1DR3 A;  4XT8 A;  5FDA A;  3UM6 A;  1CD2 A;  3EEJ A;  5U27 A;  4H97 A;  1M79 A;  4KFJ A;  3SRU X;  5HVE A;  1RA3 A;  1DYI A;  5HI6 A;  2FZH A;  1DR6 A;  5HQZ A;  3KY8 A;  4LAH X;  1RX6 A;  3FYV X;  1MVT A;  4IXG X;  3NZC X;  1JUV A;  2CIG A;  3QYO A;  3FRA X;  4KD7 A;  3FRF X;  3FS6 A;  4NX6 A;  3QGT A;  4QLE A;  4ELF A;  3LG4 A;  4XT6 A;  4X5H A;  1JOM A;  3OCH A;  2ANQ A;  4QLG A;  3QFX A;  1RF7 A;  3KJS A;  3QL0 A;  4KLX A;  2D0K A;  1DHI A;  4XT7 A;  3QL3 A;  1QZF A;  4DP3 A;  4P3Q A;  1AO8 A;  1RA9 A;  5ECX A;  3NZ9 X;  1DRF A;  3F0U X;  4KNE A;  1DR5 A;  3TQA A;  3NXT A;  4QLF A;  4PTH A;  3DG8 A;  5JG0 X;  1RA1 A;  3QLY A;  2OIP A;  1RC4 A;  2INQ A;  4I13 A;  4QJZ D;  3NXO A;  3GI2 A;  2DHF A;  3FY8 X;  3GHV A;  1SEJ A;  4XT4 A;  3FQF A;  4XE6 X;  1RX7 A;  1RX5 A;  3JWF A;  3K47 A;  5HT4 A;  1U72 A;  3EEL A;  4NX7 A;  4KEB A;  3IRN A;  4PST A;  3N0H A;  2BLA A;  3F0S X;  3RO9 A;  2QK8 A;  1S3W A;  1RH3 A;  5CCC A;  5CC9 A;  1DR7 A;  3K45 A;  4CD2 A;  3FL8 A;  3TD8 A;  2C2T A;  3NXX A;  3ZPC A;  5HVB A;  3CD2 A;  3SRR X;  2W9H A;  4PSS A;  1VJ3 A;  4X5I A;  4M6J A;  3NXV A;  2W3M A;  3HBB A;  4KM0 A;  3DAU A;  2O7P A;  5HPB A;  4HOF A;  3GYF A;  3OAF A;  1DLR A;  1DR2 A;  3JTW A;  4I1N A;  3EEM A;  3JWK A;  3NXR A;  2W9T A;  5EAJ A;  6DFR A;  3SA2 A;  4EIZ A;  4EJ1 A;  2OBC A;  2ZZA A;  4KYA A;  1S3Y A;  5DFR A;  5DXV A;  1J3J A;  3F8Y A;  1HFQ A;  1DRH A;  1LUD A;  2P4G A;  3CL9 A;  1RX1 A;  1S3V A;  3NZD A;  5ECC A;  1CZ3 A;  1J3K A;  4Q67 A;  4H96 A;  4EIG A;  1MVS A;  3F8Z A;  3FYW X;  4H98 A;  3GHW A;  1RX9 A;  1DIS A;  2C2S A;  4DPH A;  3EX8 A;  5HQY A;  3HJ3 A;  3IX9 A;  4ELG A;  1U71 A;  3S3V A;  1RB2 A;  3DAT A;  3FY9 X;  3SR5 X;  2HM9 A;  3L3R A;  1DHJ A;  3QLS A;  4QI9 A;  3CSE A;  1BZF A;  3IRO A;  1DYH A;  1PDB A;  5HUI A;  1RG7 A;  4P3R A;  1DRA A;  3F0V X;  4X5J A;  4KJJ A;  4X5F A;  4DDR A;  3QYL A;  4DPD A;  1RA8 A;  3NZ6 X;  4ECK A;  3IRM A;  3IA5 A;  1DLS A;  3FQO A;  4XEC X;  3KGY A;  1DRB A;  1DHF A;  2HXV A;  3IA4 A;  4PDJ A;  2FZJ A;  4HOG A;  4QHV A;  4FGH A;  1DDR A;  4RGC A;  2H2Q A;  2L28 A;  4HOE A;  1BOZ A;  4TU5 X;  2W3A A;  1YHO A;  1JOL A;  4EIL A;  4M2X A;  4H95 A;  1D1G A;  4P66 A;  3FQV A;  7DFR A;  3JWM A;  3TQ8 A;  3TQ9 A;  3SRW X;  5HT5 A;  1DR1 A;  4G95 A;  4ELB A;  2CD2 A;  3NU0 A;  2ANO A;  4KJK A;  3DGA A;  3DL5 A;  1RX3 A;  4KL9 A;  1LY3 A;  3NZA X;  3FQC A;  4KM2 A;  1TDR A;  1LY4 A;  3QLW A;  3S7A A;  1ZDR A;  1DF7 A;  2AZN A;  3SRQ X;  4HA7 A;  1J3I A;  2G6V A;  4ELE A;  1PD9 A;  3DL6 A;  2BL9 A;  3ZPG A;  3QLR A;  3EIG A;  3NRR A;  3NZB X;  4OR7 A;  4KJL A;  1KMV A;  4GH8 A;  2FZI A;  3DRC A;  4KY4 A;  3RG9 A;  3D84 X;  4IXE D;  3UM8 A;  1M7A A;  3JWC A;  3NXY A;  4XT5 A;  2XW7 A;  3R33 A;  4LAE X;  4PSY A;  1DYR A;  1RB3 A;  3SH2 A;  1RE7 A;  1DYJ A;  8DFR A;  4G8Z X;  2D5N A;  2LF1 A;  1OHJ A;  4Q0D A;  3SQY X;  3D80 A;  3JSU A;  3QLZ A;  3KFY A;  4IXF X;  2KGK A;  2JYB A;  1OHK A;  4P68 A;  1DDS A;  4HA9 A; 
#chains in the Genus database with same CATH homology
 4M7V A;  3M09 A;  1RX4 A;  5U26 A;  3F0B X;  1RX2 A;  1U70 A;  5E8Q A;  3K2H A;  2W9S A;  1S3U A;  3SRS X;  3CLB A;  4QJC A;  5HSR A;  3F0Q X;  4OSG A;  3F91 A;  1AI9 A;  1DAJ A;  4Q6A A;  3VCO A;  1VDR A;  1RD7 A;  3QG2 A;  1DRE A;  3Q1H A;  4X5G A;  4M7U A;  4LAG X;  3DFR A;  2W3W A;  1KMS A;  4KBN A;  1RX8 A;  2W9G A;  1DG5 A;  3EEK A;  3FL9 A;  3UM5 A;  3INV A;  4ELH A;  2DRC A;  3QLX A;  3SA1 A;  3NTZ A;  4KAK A;  3F0X X;  3SAI A;  1DG8 A;  2HQP A;  4FHB A;  2ITH A;  4PTJ A;  3ROA A;  3E0B A;  3FRD X;  4G3M A;  3KJR A;  1PD8 A;  5HF2 X;  1IA2 A;  3GHC A;  2BLB A;  4M6L A;  3I3R A;  1HFP A;  1IA4 A;  3JW3 A;  1RA2 A;  3I8A X;  3FQZ A;  3FQ0 A;  2GD9 A;  5JA3 A;  2B3Z A;  2BLC A;  3M08 A;  1M78 A;  5HF0 X;  1E26 A;  4KY8 A;  3SGY A;  3JW5 A;  1DR4 A;  2W3B A;  4DFR A;  1IA3 A;  3K74 A;  1IA1 A;  3JVX A;  4Q0E A;  2W3V A;  3FRE X;  1KLK A;  3FRB X;  1AOE A;  3TQB A;  3S9U A;  4LEK X;  1DG7 A;  4FGG A;  4XRB A;  1DIU A;  5HSU A;  1HFR A;  4M6K A;  1DR3 A;  4XT8 A;  5FDA A;  3UM6 A;  1CD2 A;  3EEJ A;  5U27 A;  4H97 A;  1M79 A;  4KFJ A;  3SRU X;  5HVE A;  1RA3 A;  1DYI A;  5HI6 A;  2FZH A;  1DR6 A;  5HQZ A;  3KY8 A;  4LAH X;  1RX6 A;  3FYV X;  1MVT A;  4IXG X;  3NZC X;  1JUV A;  2CIG A;  3QYO A;  3FRA X;  4KD7 A;  3FRF X;  3FS6 A;  4NX6 A;  3QGT A;  4QLE A;  4ELF A;  3LG4 A;  4XT6 A;  4X5H A;  1JOM A;  3OCH A;  2ANQ A;  4QLG A;  3QFX A;  1RF7 A;  3KJS A;  3QL0 A;  4KLX A;  2D0K A;  1DHI A;  4XT7 A;  3QL3 A;  1QZF A;  4DP3 A;  4P3Q A;  1AO8 A;  1RA9 A;  5ECX A;  3NZ9 X;  1DRF A;  3F0U X;  4KNE A;  1DR5 A;  3TQA A;  3NXT A;  4QLF A;  4PTH A;  3DG8 A;  5JG0 X;  1RA1 A;  3QLY A;  2OIP A;  1RC4 A;  2INQ A;  4I13 A;  4QJZ D;  3NXO A;  3GI2 A;  2DHF A;  3FY8 X;  3GHV A;  1SEJ A;  4XT4 A;  3FQF A;  4XE6 X;  1RX7 A;  1RX5 A;  3JWF A;  3K47 A;  5HT4 A;  1U72 A;  3EEL A;  4NX7 A;  4KEB A;  3IRN A;  4PST A;  3N0H A;  2BLA A;  3F0S X;  3RO9 A;  2QK8 A;  1S3W A;  1RH3 A;  5CCC A;  5CC9 A;  1DR7 A;  3K45 A;  4CD2 A;  3FL8 A;  3TD8 A;  2C2T A;  3NXX A;  3ZPC A;  5HVB A;  3CD2 A;  3SRR X;  2W9H A;  4PSS A;  1VJ3 A;  4X5I A;  4M6J A;  3NXV A;  2W3M A;  3HBB A;  4KM0 A;  3DAU A;  2O7P A;  5HPB A;  4HOF A;  3GYF A;  3OAF A;  1DLR A;  1DR2 A;  3JTW A;  4I1N A;  3EEM A;  3JWK A;  3NXR A;  2W9T A;  5EAJ A;  6DFR A;  3SA2 A;  4EIZ A;  4EJ1 A;  2OBC A;  2ZZA A;  4KYA A;  1S3Y A;  5DFR A;  5DXV A;  1J3J A;  3F8Y A;  1HFQ A;  1DRH A;  1LUD A;  2P4G A;  3CL9 A;  1RX1 A;  1S3V A;  3NZD A;  5ECC A;  1CZ3 A;  1J3K A;  4Q67 A;  4H96 A;  4EIG A;  1MVS A;  3F8Z A;  3FYW X;  4H98 A;  3GHW A;  1RX9 A;  1DIS A;  2C2S A;  4DPH A;  3EX8 A;  5HQY A;  3HJ3 A;  3IX9 A;  4ELG A;  1U71 A;  3S3V A;  1RB2 A;  3DAT A;  3FY9 X;  3SR5 X;  2HM9 A;  3L3R A;  1DHJ A;  3QLS A;  4QI9 A;  3CSE A;  1BZF A;  3IRO A;  1DYH A;  1PDB A;  5HUI A;  1RG7 A;  4P3R A;  1DRA A;  3F0V X;  4X5J A;  4KJJ A;  4X5F A;  4DDR A;  3QYL A;  4DPD A;  1RA8 A;  3NZ6 X;  4ECK A;  3IRM A;  3IA5 A;  1DLS A;  3FQO A;  4XEC X;  3KGY A;  1DRB A;  1DHF A;  2HXV A;  3IA4 A;  4PDJ A;  2FZJ A;  4HOG A;  4QHV A;  4FGH A;  1DDR A;  4RGC A;  2H2Q A;  2L28 A;  4HOE A;  1BOZ A;  4TU5 X;  2W3A A;  1YHO A;  1JOL A;  4EIL A;  4M2X A;  4H95 A;  1D1G A;  4P66 A;  3FQV A;  7DFR A;  3JWM A;  3TQ8 A;  3TQ9 A;  3SRW X;  5HT5 A;  1DR1 A;  4G95 A;  4ELB A;  2CD2 A;  3NU0 A;  2ANO A;  4KJK A;  3DGA A;  3DL5 A;  1RX3 A;  4KL9 A;  1LY3 A;  3NZA X;  3FQC A;  4KM2 A;  1TDR A;  1LY4 A;  3QLW A;  3S7A A;  1ZDR A;  1DF7 A;  2AZN A;  3SRQ X;  4HA7 A;  1J3I A;  2G6V A;  4ELE A;  1PD9 A;  3DL6 A;  2BL9 A;  3ZPG A;  3QLR A;  3EIG A;  3NRR A;  3NZB X;  4OR7 A;  4KJL A;  1KMV A;  4GH8 A;  2FZI A;  3DRC A;  4KY4 A;  3RG9 A;  3D84 X;  4IXE D;  3UM8 A;  1M7A A;  3JWC A;  3NXY A;  4XT5 A;  2XW7 A;  3R33 A;  4LAE X;  4PSY A;  1DYR A;  1RB3 A;  3SH2 A;  1RE7 A;  1DYJ A;  8DFR A;  4G8Z X;  2D5N A;  2LF1 A;  1OHJ A;  4Q0D A;  3SQY X;  3D80 A;  3JSU A;  3QLZ A;  3KFY A;  4IXF X;  2KGK A;  2JYB A;  1OHK A;  4P68 A;  1DDS A;  4HA9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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