4QHVA

Crystal structure of human dihydrofolate reductase as complex with pyridopyrimidine 22 (n~6~-methyl-n~6~-[4-(propan-2-yl)phenyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine)
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 54
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2014-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 4qhvA00
3INVA 1RX3A 4PTJA 5DFRA 1DG7A 4XECX 4M7VA 3SAIA 8DFRA 3NU0A 4DPHA 2DHFA 4G95A 1RH3A 1VJ3A 3ZPGA 2P4GA 4LAEX 3QYLA 1DYRA 4KLXA 2O7PA 4QJZD 1S3UA 4ELBA 4PSYA 4X5JA 3IRMA 4FGGA 3NZDA 4P3QA 3FQCA 4H98A 1DR3A 3S3VA 2FZIA 4HA7A 5U27A 3JWKA 3F0UX 3D84X 1J3IA 1DHIA 3FL9A 1JOLA 1LY4A 3SGYA 4XE6X 5ECXA 1OHJA 4KJJA 3JSUA 3QLXA 3QLRA 3FL8A 1RF7A 3QYOA 4KL9A 4DFRA 3OCHA 1S3WA 1DR5A 1DHFA 4KY4A 2INQA 2W9SA 5HSUA 3OAFA 4TU5X 1RX9A 3FY9X 3SA1A 3NRRA 2W3MA 4H95A 2ZZAA 4QLGA 3DGAA 3FS6A 4IXFX 1RG7A 4I13A 3QLSA 2C2SA 3SRQX 1MVTA 3NTZA 4QI9A 1E26A 3FQVA 4P68A 3CSEA 3S7AA 3I3RA 3SRWX 4I1NA 3IA5A 4M2XA 3SA2A 1RB2A 3TQ9A 3HBBA 3FYVX 3GHWA 3ROAA 2AZNA 5HPBA 3QGTA 1DG5A 3GHCA 2W3VA 4KEBA 3UM8A 3NXTA 3ZPCA 5U26A 1RB3A 5HT5A 4RGCA 2W3AA 3RO9A 4QJCA 1M78A 2ANQA 3KGYA 1U71A 3IRNA 3L3RA 4H96A 1DDRA 4PSTA 1RX2A 1M79A 4KJKA 2H2QA 1IA3A 1RA9A 2CD2A 4LEKX 2W3BA 1IA1A 3KY8A 3EELA 1JUVA 4ELEA 4HOGA 4X5IA 3EEMA 2BL9A 4EIGA 1S3YA 4XT7A 3F0VX 4KFJA 1DF7A 4XT4A 1DRFA 1D1GA 3FQ0A 3JW5A 3DL6A 3F91A 4X5GA 4P66A 4EIZA 3NZ9X 3CLBA 4FHBA 2HM9A 4XT8A 4Q0EA 3KFYA 2ITHA 4ELHA 1DIUA 2ANOA 3E0BA 3NXVA 5HQYA 1DREA 4M6JA 1RD7A 3DFRA 2BLBA 3NXOA 2C2TA 2OBCA 4G8ZX 3SRSX 3TD8A 4H97A 4HOFA 3JTWA 3TQAA 2JYBA 3FRFX 3FRAX 3QLYA 3I8AX 5HUIA 3QFXA 3FYWX 4OR7A 3QL0A 1RA8A 3DG8A 1PD8A 4KM0A 1HFPA 5E8QA 1VDRA 3S9UA 3NXRA 4KNEA 3F8YA 3FQFA 5JA3A 4M6LA 1DYJA 5EAJA 5HF2X 3JWMA 3NZCX 2G6VA 3LG4A 1BOZA 1RX6A 1AI9A 2XW7A 3DRCA 3KJSA 1DR6A 3SRUX 2LF1A 4QHVA 5FDAA 1J3JA 4LAHX 4OSGA 4LAGX 4HOEA 3JW3A 1LUDA 1S3VA 3FRDX 4GH8A 4NX7A 3FQZA 3NXYA 1HFRA 1DYHA 4PSSA 3M09A 2HXVA 3IROA 3VCOA 3JWCA 2W3WA 4ECKA 3N0HA 2FZJA 3EEJA 3EX8A 1TDRA 4PDJA 4IXED 1AOEA 3F0BX 3FRBX 3UM5A 4CD2A 3QL3A 1DRAA 2OIPA 1IA2A 5HSRA 3DATA 4IXGX 4M7UA 4QLEA 3SH2A 4M6KA 1DR2A 3DAUA 4KJLA 1JOMA 3F0QX 1J3KA 4XT5A 2QK8A 3NZBX 4Q67A 3IA4A 1M7AA 4XT6A 4NX6A 4EJ1A 1DLSA 4ELGA 4XRBA 4KBNA 1PD9A 1DHJA 2DRCA 3F8ZA 2D0KA 3M08A 3SQYX 3UM6A 4P3RA 3D80A 6DFRA 4QLFA 1AO8A 1DRBA 3IX9A 2W9HA 3DL5A 3HJ3A 5CCCA 1RX5A 4X5FA 2KGKA 5CC9A 3FQOA 1PDBA 4DP3A 1DDSA 2HQPA 1RA1A 1RA2A 1RA3A 1RC4A 3K47A 5JG0X 4KM2A 3SR5X 4DDRA 4EILA 2W9GA 3NXXA 3KJRA 1KMVA 3K2HA 2BLCA 3EEKA 4PTHA 1QZFA 4KAKA 3TQ8A 4DPDA 5DXVA 2B3ZA 4KY8A 2FZHA 2W9TA 1RE7A 1YHOA 3R33A 3JWFA 1CZ3A 1OHKA 4KYAA 5HF0X 3FY8X 5HVEA 3CD2A 3Q1HA 3K74A 2D5NA 1DG8A 1IA4A 4Q0DA 1KLKA 3GYFA 3NZAX 3F0XX 1LY3A 2BLAA 4ELFA 1U70A 1CD2A 1BZFA 1RX7A 2CIGA 3CL9A 1KMSA 1SEJA 3JVXA 1RX4A 3NZ6X 2L28A 1HFQA 1RX1A 1DR1A 5HVBA 1DYIA 3TQBA 3RG9A 1DISA 1MVSA 4KD7A 3SRRX 4FGHA 4X5HA 1U72A 5HT4A 4HA9A 3GI2A 1DR4A 3QLWA 5ECCA 1ZDRA 1DLRA 1DRHA 7DFRA 3QG2A 4Q6AA 5HI6A 3GHVA 3FREX 3EIGA 3F0SX 2GD9A 1DAJA 1DR7A 5HQZA 4G3MA 3K45A 3QLZA 1RX8A
chains in the Genus database with same CATH superfamily
3INVA 1RX3A 4PTJA 5DFRA 1DG7A 4XECX 4M7VA 3SAIA 8DFRA 3NU0A 4DPHA 2DHFA 4G95A 1RH3A 1VJ3A 3ZPGA 2P4GA 4LAEX 3QYLA 1DYRA 4KLXA 2O7PA 4QJZD 1S3UA 4ELBA 4PSYA 4X5JA 3IRMA 4FGGA 3NZDA 4P3QA 3FQCA 4H98A 1DR3A 3S3VA 2FZIA 4HA7A 5U27A 3JWKA 3F0UX 3D84X 1J3IA 1DHIA 3FL9A 1JOLA 1LY4A 3SGYA 4XE6X 5ECXA 1OHJA 4KJJA 3JSUA 3QLXA 3QLRA 3FL8A 1RF7A 3QYOA 4KL9A 4DFRA 3OCHA 1S3WA 1DR5A 1DHFA 4KY4A 2INQA 2W9SA 5HSUA 3OAFA 4TU5X 1RX9A 3FY9X 3SA1A 3NRRA 2W3MA 4H95A 2ZZAA 4QLGA 3DGAA 3FS6A 4IXFX 1RG7A 4I13A 3QLSA 2C2SA 3SRQX 1MVTA 3NTZA 4QI9A 1E26A 3FQVA 4P68A 3CSEA 3S7AA 3I3RA 3SRWX 4I1NA 3IA5A 4M2XA 3SA2A 1RB2A 3TQ9A 3HBBA 3FYVX 3GHWA 3ROAA 2AZNA 5HPBA 3QGTA 1DG5A 3GHCA 2W3VA 4KEBA 3UM8A 3NXTA 3ZPCA 5U26A 1RB3A 5HT5A 4RGCA 2W3AA 3RO9A 4QJCA 1M78A 2ANQA 3KGYA 1U71A 3IRNA 3L3RA 4H96A 1DDRA 4PSTA 1RX2A 1M79A 4KJKA 2H2QA 1IA3A 1RA9A 2CD2A 4LEKX 2W3BA 1IA1A 3KY8A 3EELA 1JUVA 4ELEA 4HOGA 4X5IA 3EEMA 2BL9A 4EIGA 1S3YA 4XT7A 3F0VX 4KFJA 1DF7A 4XT4A 1DRFA 1D1GA 3FQ0A 3JW5A 3DL6A 3F91A 4X5GA 4P66A 4EIZA 3NZ9X 3CLBA 4FHBA 2HM9A 4XT8A 4Q0EA 3KFYA 2ITHA 4ELHA 1DIUA 2ANOA 3E0BA 3NXVA 5HQYA 1DREA 4M6JA 1RD7A 3DFRA 2BLBA 3NXOA 2C2TA 2OBCA 4G8ZX 3SRSX 3TD8A 4H97A 4HOFA 3JTWA 3TQAA 2JYBA 3FRFX 3FRAX 3QLYA 3I8AX 5HUIA 3QFXA 3FYWX 4OR7A 3QL0A 1RA8A 3DG8A 1PD8A 4KM0A 1HFPA 5E8QA 1VDRA 3S9UA 3NXRA 4KNEA 3F8YA 3FQFA 5JA3A 4M6LA 1DYJA 5EAJA 5HF2X 3JWMA 3NZCX 2G6VA 3LG4A 1BOZA 1RX6A 1AI9A 2XW7A 3DRCA 3KJSA 1DR6A 3SRUX 2LF1A 4QHVA 5FDAA 1J3JA 4LAHX 4OSGA 4LAGX 4HOEA 3JW3A 1LUDA 1S3VA 3FRDX 4GH8A 4NX7A 3FQZA 3NXYA 1HFRA 1DYHA 4PSSA 3M09A 2HXVA 3IROA 3VCOA 3JWCA 2W3WA 4ECKA 3N0HA 2FZJA 3EEJA 3EX8A 1TDRA 4PDJA 4IXED 1AOEA 3F0BX 3FRBX 3UM5A 4CD2A 3QL3A 1DRAA 2OIPA 1IA2A 5HSRA 3DATA 4IXGX 4M7UA 4QLEA 3SH2A 4M6KA 1DR2A 3DAUA 4KJLA 1JOMA 3F0QX 1J3KA 4XT5A 2QK8A 3NZBX 4Q67A 3IA4A 1M7AA 4XT6A 4NX6A 4EJ1A 1DLSA 4ELGA 4XRBA 4KBNA 1PD9A 1DHJA 2DRCA 3F8ZA 2D0KA 3M08A 3SQYX 3UM6A 4P3RA 3D80A 6DFRA 4QLFA 1AO8A 1DRBA 3IX9A 2W9HA 3DL5A 3HJ3A 5CCCA 1RX5A 4X5FA 2KGKA 5CC9A 3FQOA 1PDBA 4DP3A 1DDSA 2HQPA 1RA1A 1RA2A 1RA3A 1RC4A 3K47A 5JG0X 4KM2A 3SR5X 4DDRA 4EILA 2W9GA 3NXXA 3KJRA 1KMVA 3K2HA 2BLCA 3EEKA 4PTHA 1QZFA 4KAKA 3TQ8A 4DPDA 5DXVA 2B3ZA 4KY8A 2FZHA 2W9TA 1RE7A 1YHOA 3R33A 3JWFA 1CZ3A 1OHKA 4KYAA 5HF0X 3FY8X 5HVEA 3CD2A 3Q1HA 3K74A 2D5NA 1DG8A 1IA4A 4Q0DA 1KLKA 3GYFA 3NZAX 3F0XX 1LY3A 2BLAA 4ELFA 1U70A 1CD2A 1BZFA 1RX7A 2CIGA 3CL9A 1KMSA 1SEJA 3JVXA 1RX4A 3NZ6X 2L28A 1HFQA 1RX1A 1DR1A 5HVBA 1DYIA 3TQBA 3RG9A 1DISA 1MVSA 4KD7A 3SRRX 4FGHA 4X5HA 1U72A 5HT4A 4HA9A 3GI2A 1DR4A 3QLWA 5ECCA 1ZDRA 1DLRA 1DRHA 7DFRA 3QG2A 4Q6AA 5HI6A 3GHVA 3FREX 3EIGA 3F0SX 2GD9A 1DAJA 1DR7A 5HQZA 4G3MA 3K45A 3QLZA 1RX8A
chains in the Genus database with same CATH topology
3INVA 1RX3A 4PTJA 5DFRA 1DG7A 4XECX 4M7VA 3SAIA 8DFRA 3NU0A 4DPHA 2DHFA 4G95A 1RH3A 1VJ3A 3ZPGA 2P4GA 4LAEX 3QYLA 1DYRA 4KLXA 2O7PA 4QJZD 1S3UA 4ELBA 4PSYA 4X5JA 3IRMA 4FGGA 3NZDA 4P3QA 3FQCA 4H98A 1DR3A 3S3VA 2FZIA 4HA7A 5U27A 3JWKA 3F0UX 3D84X 1J3IA 1DHIA 3FL9A 1JOLA 1LY4A 3SGYA 4XE6X 5ECXA 1OHJA 4KJJA 3JSUA 3QLXA 3QLRA 3FL8A 1RF7A 3QYOA 4KL9A 4DFRA 3OCHA 1S3WA 1DR5A 1DHFA 4KY4A 2INQA 2W9SA 5HSUA 3OAFA 4TU5X 1RX9A 3FY9X 3SA1A 3NRRA 2W3MA 4H95A 2ZZAA 4QLGA 3DGAA 3FS6A 4IXFX 1RG7A 4I13A 3QLSA 2C2SA 3SRQX 1MVTA 3NTZA 4QI9A 1E26A 3FQVA 4P68A 3CSEA 3S7AA 3I3RA 3SRWX 4I1NA 3IA5A 4M2XA 3SA2A 1RB2A 3TQ9A 3HBBA 3FYVX 3GHWA 3ROAA 2AZNA 5HPBA 3QGTA 1DG5A 3GHCA 2W3VA 4KEBA 3UM8A 3NXTA 3ZPCA 5U26A 1RB3A 5HT5A 4RGCA 2W3AA 3RO9A 4QJCA 1M78A 2ANQA 3KGYA 1U71A 3IRNA 3L3RA 4H96A 1DDRA 4PSTA 1RX2A 1M79A 4KJKA 2H2QA 1IA3A 1RA9A 2CD2A 4LEKX 2W3BA 1IA1A 3KY8A 3EELA 1JUVA 4ELEA 4HOGA 4X5IA 3EEMA 2BL9A 4EIGA 1S3YA 4XT7A 3F0VX 4KFJA 1DF7A 4XT4A 1DRFA 1D1GA 3FQ0A 3JW5A 3DL6A 3F91A 4X5GA 4P66A 4EIZA 3NZ9X 3CLBA 4FHBA 2HM9A 4XT8A 4Q0EA 3KFYA 2ITHA 4ELHA 1DIUA 2ANOA 3E0BA 3NXVA 5HQYA 1DREA 4M6JA 1RD7A 3DFRA 2BLBA 3NXOA 2C2TA 2OBCA 4G8ZX 3SRSX 3TD8A 4H97A 4HOFA 3JTWA 3TQAA 2JYBA 3FRFX 3FRAX 3QLYA 3I8AX 5HUIA 3QFXA 3FYWX 4OR7A 3QL0A 1RA8A 3DG8A 1PD8A 4KM0A 1HFPA 5E8QA 1VDRA 3S9UA 3NXRA 4KNEA 3F8YA 3FQFA 5JA3A 4M6LA 1DYJA 5EAJA 5HF2X 3JWMA 3NZCX 2G6VA 3LG4A 1BOZA 1RX6A 1AI9A 2XW7A 3DRCA 3KJSA 1DR6A 3SRUX 2LF1A 4QHVA 5FDAA 1J3JA 4LAHX 4OSGA 4LAGX 4HOEA 3JW3A 1LUDA 1S3VA 3FRDX 4GH8A 4NX7A 3FQZA 3NXYA 1HFRA 1DYHA 4PSSA 3M09A 2HXVA 3IROA 3VCOA 3JWCA 2W3WA 4ECKA 3N0HA 2FZJA 3EEJA 3EX8A 1TDRA 4PDJA 4IXED 1AOEA 3F0BX 3FRBX 3UM5A 4CD2A 3QL3A 1DRAA 2OIPA 1IA2A 5HSRA 3DATA 4IXGX 4M7UA 4QLEA 3SH2A 4M6KA 1DR2A 3DAUA 4KJLA 1JOMA 3F0QX 1J3KA 4XT5A 2QK8A 3NZBX 4Q67A 3IA4A 1M7AA 4XT6A 4NX6A 4EJ1A 1DLSA 4ELGA 4XRBA 4KBNA 1PD9A 1DHJA 2DRCA 3F8ZA 2D0KA 3M08A 3SQYX 3UM6A 4P3RA 3D80A 6DFRA 4QLFA 1AO8A 1DRBA 3IX9A 2W9HA 3DL5A 3HJ3A 5CCCA 1RX5A 4X5FA 2KGKA 5CC9A 3FQOA 1PDBA 4DP3A 1DDSA 2HQPA 1RA1A 1RA2A 1RA3A 1RC4A 3K47A 5JG0X 4KM2A 3SR5X 4DDRA 4EILA 2W9GA 3NXXA 3KJRA 1KMVA 3K2HA 2BLCA 3EEKA 4PTHA 1QZFA 4KAKA 3TQ8A 4DPDA 5DXVA 2B3ZA 4KY8A 2FZHA 2W9TA 1RE7A 1YHOA 3R33A 3JWFA 1CZ3A 1OHKA 4KYAA 5HF0X 3FY8X 5HVEA 3CD2A 3Q1HA 3K74A 2D5NA 1DG8A 1IA4A 4Q0DA 1KLKA 3GYFA 3NZAX 3F0XX 1LY3A 2BLAA 4ELFA 1U70A 1CD2A 1BZFA 1RX7A 2CIGA 3CL9A 1KMSA 1SEJA 3JVXA 1RX4A 3NZ6X 2L28A 1HFQA 1RX1A 1DR1A 5HVBA 1DYIA 3TQBA 3RG9A 1DISA 1MVSA 4KD7A 3SRRX 4FGHA 4X5HA 1U72A 5HT4A 4HA9A 3GI2A 1DR4A 3QLWA 5ECCA 1ZDRA 1DLRA 1DRHA 7DFRA 3QG2A 4Q6AA 5HI6A 3GHVA 3FREX 3EIGA 3F0SX 2GD9A 1DAJA 1DR7A 5HQZA 4G3MA 3K45A 3QLZA 1RX8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3INV A;  1RX3 A;  4PTJ A;  5DFR A;  1DG7 A;  4XEC X;  4M7V A;  3SAI A;  8DFR A;  3NU0 A;  4DPH A;  2DHF A;  4G95 A;  1RH3 A;  1VJ3 A;  3ZPG A;  2P4G A;  4LAE X;  3QYL A;  1DYR A;  4KLX A;  2O7P A;  4QJZ D;  1S3U A;  4ELB A;  4PSY A;  4X5J A;  3IRM A;  4FGG A;  3NZD A;  4P3Q A;  3FQC A;  4H98 A;  1DR3 A;  3S3V A;  2FZI A;  4HA7 A;  5U27 A;  3JWK A;  3F0U X;  3D84 X;  1J3I A;  1DHI A;  3FL9 A;  1JOL A;  1LY4 A;  3SGY A;  4XE6 X;  5ECX A;  1OHJ A;  4KJJ A;  3JSU A;  3QLX A;  3QLR A;  3FL8 A;  1RF7 A;  3QYO A;  4KL9 A;  4DFR A;  3OCH A;  1S3W A;  1DR5 A;  1DHF A;  4KY4 A;  2INQ A;  2W9S A;  5HSU A;  3OAF A;  4TU5 X;  1RX9 A;  3FY9 X;  3SA1 A;  3NRR A;  2W3M A;  4H95 A;  2ZZA A;  4QLG A;  3DGA A;  3FS6 A;  4IXF X;  1RG7 A;  4I13 A;  3QLS A;  2C2S A;  3SRQ X;  1MVT A;  3NTZ A;  4QI9 A;  1E26 A;  3FQV A;  4P68 A;  3CSE A;  3S7A A;  3I3R A;  3SRW X;  4I1N A;  3IA5 A;  4M2X A;  3SA2 A;  1RB2 A;  3TQ9 A;  3HBB A;  3FYV X;  3GHW A;  3ROA A;  2AZN A;  5HPB A;  3QGT A;  1DG5 A;  3GHC A;  2W3V A;  4KEB A;  3UM8 A;  3NXT A;  3ZPC A;  5U26 A;  1RB3 A;  5HT5 A;  4RGC A;  2W3A A;  3RO9 A;  4QJC A;  1M78 A;  2ANQ A;  3KGY A;  1U71 A;  3IRN A;  3L3R A;  4H96 A;  1DDR A;  4PST A;  1RX2 A;  1M79 A;  4KJK A;  2H2Q A;  1IA3 A;  1RA9 A;  2CD2 A;  4LEK X;  2W3B A;  1IA1 A;  3KY8 A;  3EEL A;  1JUV A;  4ELE A;  4HOG A;  4X5I A;  3EEM A;  2BL9 A;  4EIG A;  1S3Y A;  4XT7 A;  3F0V X;  4KFJ A;  1DF7 A;  4XT4 A;  1DRF A;  1D1G A;  3FQ0 A;  3JW5 A;  3DL6 A;  3F91 A;  4X5G A;  4P66 A;  4EIZ A;  3NZ9 X;  3CLB A;  4FHB A;  2HM9 A;  4XT8 A;  4Q0E A;  3KFY A;  2ITH A;  4ELH A;  1DIU A;  2ANO A;  3E0B A;  3NXV A;  5HQY A;  1DRE A;  4M6J A;  1RD7 A;  3DFR A;  2BLB A;  3NXO A;  2C2T A;  2OBC A;  4G8Z X;  3SRS X;  3TD8 A;  4H97 A;  4HOF A;  3JTW A;  3TQA A;  2JYB A;  3FRF X;  3FRA X;  3QLY A;  3I8A X;  5HUI A;  3QFX A;  3FYW X;  4OR7 A;  3QL0 A;  1RA8 A;  3DG8 A;  1PD8 A;  4KM0 A;  1HFP A;  5E8Q A;  1VDR A;  3S9U A;  3NXR A;  4KNE A;  3F8Y A;  3FQF A;  5JA3 A;  4M6L A;  1DYJ A;  5EAJ A;  5HF2 X;  3JWM A;  3NZC X;  2G6V A;  3LG4 A;  1BOZ A;  1RX6 A;  1AI9 A;  2XW7 A;  3DRC A;  3KJS A;  1DR6 A;  3SRU X;  2LF1 A;  4QHV A;  5FDA A;  1J3J A;  4LAH X;  4OSG A;  4LAG X;  4HOE A;  3JW3 A;  1LUD A;  1S3V A;  3FRD X;  4GH8 A;  4NX7 A;  3FQZ A;  3NXY A;  1HFR A;  1DYH A;  4PSS A;  3M09 A;  2HXV A;  3IRO A;  3VCO A;  3JWC A;  2W3W A;  4ECK A;  3N0H A;  2FZJ A;  3EEJ A;  3EX8 A;  1TDR A;  4PDJ A;  4IXE D;  1AOE A;  3F0B X;  3FRB X;  3UM5 A;  4CD2 A;  3QL3 A;  1DRA A;  2OIP A;  1IA2 A;  5HSR A;  3DAT A;  4IXG X;  4M7U A;  4QLE A;  3SH2 A;  4M6K A;  1DR2 A;  3DAU A;  4KJL A;  1JOM A;  3F0Q X;  1J3K A;  4XT5 A;  2QK8 A;  3NZB X;  4Q67 A;  3IA4 A;  1M7A A;  4XT6 A;  4NX6 A;  4EJ1 A;  1DLS A;  4ELG A;  4XRB A;  4KBN A;  1PD9 A;  1DHJ A;  2DRC A;  3F8Z A;  2D0K A;  3M08 A;  3SQY X;  3UM6 A;  4P3R A;  3D80 A;  6DFR A;  4QLF A;  1AO8 A;  1DRB A;  3IX9 A;  2W9H A;  3DL5 A;  3HJ3 A;  5CCC A;  1RX5 A;  4X5F A;  2KGK A;  5CC9 A;  3FQO A;  1PDB A;  4DP3 A;  1DDS A;  2HQP A;  1RA1 A;  1RA2 A;  1RA3 A;  1RC4 A;  3K47 A;  5JG0 X;  4KM2 A;  3SR5 X;  4DDR A;  4EIL A;  2W9G A;  3NXX A;  3KJR A;  1KMV A;  3K2H A;  2BLC A;  3EEK A;  4PTH A;  1QZF A;  4KAK A;  3TQ8 A;  4DPD A;  5DXV A;  2B3Z A;  4KY8 A;  2FZH A;  2W9T A;  1RE7 A;  1YHO A;  3R33 A;  3JWF A;  1CZ3 A;  1OHK A;  4KYA A;  5HF0 X;  3FY8 X;  5HVE A;  3CD2 A;  3Q1H A;  3K74 A;  2D5N A;  1DG8 A;  1IA4 A;  4Q0D A;  1KLK A;  3GYF A;  3NZA X;  3F0X X;  1LY3 A;  2BLA A;  4ELF A;  1U70 A;  1CD2 A;  1BZF A;  1RX7 A;  2CIG A;  3CL9 A;  1KMS A;  1SEJ A;  3JVX A;  1RX4 A;  3NZ6 X;  2L28 A;  1HFQ A;  1RX1 A;  1DR1 A;  5HVB A;  1DYI A;  3TQB A;  3RG9 A;  1DIS A;  1MVS A;  4KD7 A;  3SRR X;  4FGH A;  4X5H A;  1U72 A;  5HT4 A;  4HA9 A;  3GI2 A;  1DR4 A;  3QLW A;  5ECC A;  1ZDR A;  1DLR A;  1DRH A;  7DFR A;  3QG2 A;  4Q6A A;  5HI6 A;  3GHV A;  3FRE X;  3EIG A;  3F0S X;  2GD9 A;  1DAJ A;  1DR7 A;  5HQZ A;  4G3M A;  3K45 A;  3QLZ A;  1RX8 A; 
#chains in the Genus database with same CATH topology
 3INV A;  1RX3 A;  4PTJ A;  5DFR A;  1DG7 A;  4XEC X;  4M7V A;  3SAI A;  8DFR A;  3NU0 A;  4DPH A;  2DHF A;  4G95 A;  1RH3 A;  1VJ3 A;  3ZPG A;  2P4G A;  4LAE X;  3QYL A;  1DYR A;  4KLX A;  2O7P A;  4QJZ D;  1S3U A;  4ELB A;  4PSY A;  4X5J A;  3IRM A;  4FGG A;  3NZD A;  4P3Q A;  3FQC A;  4H98 A;  1DR3 A;  3S3V A;  2FZI A;  4HA7 A;  5U27 A;  3JWK A;  3F0U X;  3D84 X;  1J3I A;  1DHI A;  3FL9 A;  1JOL A;  1LY4 A;  3SGY A;  4XE6 X;  5ECX A;  1OHJ A;  4KJJ A;  3JSU A;  3QLX A;  3QLR A;  3FL8 A;  1RF7 A;  3QYO A;  4KL9 A;  4DFR A;  3OCH A;  1S3W A;  1DR5 A;  1DHF A;  4KY4 A;  2INQ A;  2W9S A;  5HSU A;  3OAF A;  4TU5 X;  1RX9 A;  3FY9 X;  3SA1 A;  3NRR A;  2W3M A;  4H95 A;  2ZZA A;  4QLG A;  3DGA A;  3FS6 A;  4IXF X;  1RG7 A;  4I13 A;  3QLS A;  2C2S A;  3SRQ X;  1MVT A;  3NTZ A;  4QI9 A;  1E26 A;  3FQV A;  4P68 A;  3CSE A;  3S7A A;  3I3R A;  3SRW X;  4I1N A;  3IA5 A;  4M2X A;  3SA2 A;  1RB2 A;  3TQ9 A;  3HBB A;  3FYV X;  3GHW A;  3ROA A;  2AZN A;  5HPB A;  3QGT A;  1DG5 A;  3GHC A;  2W3V A;  4KEB A;  3UM8 A;  3NXT A;  3ZPC A;  5U26 A;  1RB3 A;  5HT5 A;  4RGC A;  2W3A A;  3RO9 A;  4QJC A;  1M78 A;  2ANQ A;  3KGY A;  1U71 A;  3IRN A;  3L3R A;  4H96 A;  1DDR A;  4PST A;  1RX2 A;  1M79 A;  4KJK A;  2H2Q A;  1IA3 A;  1RA9 A;  2CD2 A;  4LEK X;  2W3B A;  1IA1 A;  3KY8 A;  3EEL A;  1JUV A;  4ELE A;  4HOG A;  4X5I A;  3EEM A;  2BL9 A;  4EIG A;  1S3Y A;  4XT7 A;  3F0V X;  4KFJ A;  1DF7 A;  4XT4 A;  1DRF A;  1D1G A;  3FQ0 A;  3JW5 A;  3DL6 A;  3F91 A;  4X5G A;  4P66 A;  4EIZ A;  3NZ9 X;  3CLB A;  4FHB A;  2HM9 A;  4XT8 A;  4Q0E A;  3KFY A;  2ITH A;  4ELH A;  1DIU A;  2ANO A;  3E0B A;  3NXV A;  5HQY A;  1DRE A;  4M6J A;  1RD7 A;  3DFR A;  2BLB A;  3NXO A;  2C2T A;  2OBC A;  4G8Z X;  3SRS X;  3TD8 A;  4H97 A;  4HOF A;  3JTW A;  3TQA A;  2JYB A;  3FRF X;  3FRA X;  3QLY A;  3I8A X;  5HUI A;  3QFX A;  3FYW X;  4OR7 A;  3QL0 A;  1RA8 A;  3DG8 A;  1PD8 A;  4KM0 A;  1HFP A;  5E8Q A;  1VDR A;  3S9U A;  3NXR A;  4KNE A;  3F8Y A;  3FQF A;  5JA3 A;  4M6L A;  1DYJ A;  5EAJ A;  5HF2 X;  3JWM A;  3NZC X;  2G6V A;  3LG4 A;  1BOZ A;  1RX6 A;  1AI9 A;  2XW7 A;  3DRC A;  3KJS A;  1DR6 A;  3SRU X;  2LF1 A;  4QHV A;  5FDA A;  1J3J A;  4LAH X;  4OSG A;  4LAG X;  4HOE A;  3JW3 A;  1LUD A;  1S3V A;  3FRD X;  4GH8 A;  4NX7 A;  3FQZ A;  3NXY A;  1HFR A;  1DYH A;  4PSS A;  3M09 A;  2HXV A;  3IRO A;  3VCO A;  3JWC A;  2W3W A;  4ECK A;  3N0H A;  2FZJ A;  3EEJ A;  3EX8 A;  1TDR A;  4PDJ A;  4IXE D;  1AOE A;  3F0B X;  3FRB X;  3UM5 A;  4CD2 A;  3QL3 A;  1DRA A;  2OIP A;  1IA2 A;  5HSR A;  3DAT A;  4IXG X;  4M7U A;  4QLE A;  3SH2 A;  4M6K A;  1DR2 A;  3DAU A;  4KJL A;  1JOM A;  3F0Q X;  1J3K A;  4XT5 A;  2QK8 A;  3NZB X;  4Q67 A;  3IA4 A;  1M7A A;  4XT6 A;  4NX6 A;  4EJ1 A;  1DLS A;  4ELG A;  4XRB A;  4KBN A;  1PD9 A;  1DHJ A;  2DRC A;  3F8Z A;  2D0K A;  3M08 A;  3SQY X;  3UM6 A;  4P3R A;  3D80 A;  6DFR A;  4QLF A;  1AO8 A;  1DRB A;  3IX9 A;  2W9H A;  3DL5 A;  3HJ3 A;  5CCC A;  1RX5 A;  4X5F A;  2KGK A;  5CC9 A;  3FQO A;  1PDB A;  4DP3 A;  1DDS A;  2HQP A;  1RA1 A;  1RA2 A;  1RA3 A;  1RC4 A;  3K47 A;  5JG0 X;  4KM2 A;  3SR5 X;  4DDR A;  4EIL A;  2W9G A;  3NXX A;  3KJR A;  1KMV A;  3K2H A;  2BLC A;  3EEK A;  4PTH A;  1QZF A;  4KAK A;  3TQ8 A;  4DPD A;  5DXV A;  2B3Z A;  4KY8 A;  2FZH A;  2W9T A;  1RE7 A;  1YHO A;  3R33 A;  3JWF A;  1CZ3 A;  1OHK A;  4KYA A;  5HF0 X;  3FY8 X;  5HVE A;  3CD2 A;  3Q1H A;  3K74 A;  2D5N A;  1DG8 A;  1IA4 A;  4Q0D A;  1KLK A;  3GYF A;  3NZA X;  3F0X X;  1LY3 A;  2BLA A;  4ELF A;  1U70 A;  1CD2 A;  1BZF A;  1RX7 A;  2CIG A;  3CL9 A;  1KMS A;  1SEJ A;  3JVX A;  1RX4 A;  3NZ6 X;  2L28 A;  1HFQ A;  1RX1 A;  1DR1 A;  5HVB A;  1DYI A;  3TQB A;  3RG9 A;  1DIS A;  1MVS A;  4KD7 A;  3SRR X;  4FGH A;  4X5H A;  1U72 A;  5HT4 A;  4HA9 A;  3GI2 A;  1DR4 A;  3QLW A;  5ECC A;  1ZDR A;  1DLR A;  1DRH A;  7DFR A;  3QG2 A;  4Q6A A;  5HI6 A;  3GHV A;  3FRE X;  3EIG A;  3F0S X;  2GD9 A;  1DAJ A;  1DR7 A;  5HQZ A;  4G3M A;  3K45 A;  3QLZ A;  1RX8 A; 
#chains in the Genus database with same CATH homology
 3INV A;  1RX3 A;  4PTJ A;  5DFR A;  1DG7 A;  4XEC X;  4M7V A;  3SAI A;  8DFR A;  3NU0 A;  4DPH A;  2DHF A;  4G95 A;  1RH3 A;  1VJ3 A;  3ZPG A;  2P4G A;  4LAE X;  3QYL A;  1DYR A;  4KLX A;  2O7P A;  4QJZ D;  1S3U A;  4ELB A;  4PSY A;  4X5J A;  3IRM A;  4FGG A;  3NZD A;  4P3Q A;  3FQC A;  4H98 A;  1DR3 A;  3S3V A;  2FZI A;  4HA7 A;  5U27 A;  3JWK A;  3F0U X;  3D84 X;  1J3I A;  1DHI A;  3FL9 A;  1JOL A;  1LY4 A;  3SGY A;  4XE6 X;  5ECX A;  1OHJ A;  4KJJ A;  3JSU A;  3QLX A;  3QLR A;  3FL8 A;  1RF7 A;  3QYO A;  4KL9 A;  4DFR A;  3OCH A;  1S3W A;  1DR5 A;  1DHF A;  4KY4 A;  2INQ A;  2W9S A;  5HSU A;  3OAF A;  4TU5 X;  1RX9 A;  3FY9 X;  3SA1 A;  3NRR A;  2W3M A;  4H95 A;  2ZZA A;  4QLG A;  3DGA A;  3FS6 A;  4IXF X;  1RG7 A;  4I13 A;  3QLS A;  2C2S A;  3SRQ X;  1MVT A;  3NTZ A;  4QI9 A;  1E26 A;  3FQV A;  4P68 A;  3CSE A;  3S7A A;  3I3R A;  3SRW X;  4I1N A;  3IA5 A;  4M2X A;  3SA2 A;  1RB2 A;  3TQ9 A;  3HBB A;  3FYV X;  3GHW A;  3ROA A;  2AZN A;  5HPB A;  3QGT A;  1DG5 A;  3GHC A;  2W3V A;  4KEB A;  3UM8 A;  3NXT A;  3ZPC A;  5U26 A;  1RB3 A;  5HT5 A;  4RGC A;  2W3A A;  3RO9 A;  4QJC A;  1M78 A;  2ANQ A;  3KGY A;  1U71 A;  3IRN A;  3L3R A;  4H96 A;  1DDR A;  4PST A;  1RX2 A;  1M79 A;  4KJK A;  2H2Q A;  1IA3 A;  1RA9 A;  2CD2 A;  4LEK X;  2W3B A;  1IA1 A;  3KY8 A;  3EEL A;  1JUV A;  4ELE A;  4HOG A;  4X5I A;  3EEM A;  2BL9 A;  4EIG A;  1S3Y A;  4XT7 A;  3F0V X;  4KFJ A;  1DF7 A;  4XT4 A;  1DRF A;  1D1G A;  3FQ0 A;  3JW5 A;  3DL6 A;  3F91 A;  4X5G A;  4P66 A;  4EIZ A;  3NZ9 X;  3CLB A;  4FHB A;  2HM9 A;  4XT8 A;  4Q0E A;  3KFY A;  2ITH A;  4ELH A;  1DIU A;  2ANO A;  3E0B A;  3NXV A;  5HQY A;  1DRE A;  4M6J A;  1RD7 A;  3DFR A;  2BLB A;  3NXO A;  2C2T A;  2OBC A;  4G8Z X;  3SRS X;  3TD8 A;  4H97 A;  4HOF A;  3JTW A;  3TQA A;  2JYB A;  3FRF X;  3FRA X;  3QLY A;  3I8A X;  5HUI A;  3QFX A;  3FYW X;  4OR7 A;  3QL0 A;  1RA8 A;  3DG8 A;  1PD8 A;  4KM0 A;  1HFP A;  5E8Q A;  1VDR A;  3S9U A;  3NXR A;  4KNE A;  3F8Y A;  3FQF A;  5JA3 A;  4M6L A;  1DYJ A;  5EAJ A;  5HF2 X;  3JWM A;  3NZC X;  2G6V A;  3LG4 A;  1BOZ A;  1RX6 A;  1AI9 A;  2XW7 A;  3DRC A;  3KJS A;  1DR6 A;  3SRU X;  2LF1 A;  4QHV A;  5FDA A;  1J3J A;  4LAH X;  4OSG A;  4LAG X;  4HOE A;  3JW3 A;  1LUD A;  1S3V A;  3FRD X;  4GH8 A;  4NX7 A;  3FQZ A;  3NXY A;  1HFR A;  1DYH A;  4PSS A;  3M09 A;  2HXV A;  3IRO A;  3VCO A;  3JWC A;  2W3W A;  4ECK A;  3N0H A;  2FZJ A;  3EEJ A;  3EX8 A;  1TDR A;  4PDJ A;  4IXE D;  1AOE A;  3F0B X;  3FRB X;  3UM5 A;  4CD2 A;  3QL3 A;  1DRA A;  2OIP A;  1IA2 A;  5HSR A;  3DAT A;  4IXG X;  4M7U A;  4QLE A;  3SH2 A;  4M6K A;  1DR2 A;  3DAU A;  4KJL A;  1JOM A;  3F0Q X;  1J3K A;  4XT5 A;  2QK8 A;  3NZB X;  4Q67 A;  3IA4 A;  1M7A A;  4XT6 A;  4NX6 A;  4EJ1 A;  1DLS A;  4ELG A;  4XRB A;  4KBN A;  1PD9 A;  1DHJ A;  2DRC A;  3F8Z A;  2D0K A;  3M08 A;  3SQY X;  3UM6 A;  4P3R A;  3D80 A;  6DFR A;  4QLF A;  1AO8 A;  1DRB A;  3IX9 A;  2W9H A;  3DL5 A;  3HJ3 A;  5CCC A;  1RX5 A;  4X5F A;  2KGK A;  5CC9 A;  3FQO A;  1PDB A;  4DP3 A;  1DDS A;  2HQP A;  1RA1 A;  1RA2 A;  1RA3 A;  1RC4 A;  3K47 A;  5JG0 X;  4KM2 A;  3SR5 X;  4DDR A;  4EIL A;  2W9G A;  3NXX A;  3KJR A;  1KMV A;  3K2H A;  2BLC A;  3EEK A;  4PTH A;  1QZF A;  4KAK A;  3TQ8 A;  4DPD A;  5DXV A;  2B3Z A;  4KY8 A;  2FZH A;  2W9T A;  1RE7 A;  1YHO A;  3R33 A;  3JWF A;  1CZ3 A;  1OHK A;  4KYA A;  5HF0 X;  3FY8 X;  5HVE A;  3CD2 A;  3Q1H A;  3K74 A;  2D5N A;  1DG8 A;  1IA4 A;  4Q0D A;  1KLK A;  3GYF A;  3NZA X;  3F0X X;  1LY3 A;  2BLA A;  4ELF A;  1U70 A;  1CD2 A;  1BZF A;  1RX7 A;  2CIG A;  3CL9 A;  1KMS A;  1SEJ A;  3JVX A;  1RX4 A;  3NZ6 X;  2L28 A;  1HFQ A;  1RX1 A;  1DR1 A;  5HVB A;  1DYI A;  3TQB A;  3RG9 A;  1DIS A;  1MVS A;  4KD7 A;  3SRR X;  4FGH A;  4X5H A;  1U72 A;  5HT4 A;  4HA9 A;  3GI2 A;  1DR4 A;  3QLW A;  5ECC A;  1ZDR A;  1DLR A;  1DRH A;  7DFR A;  3QG2 A;  4Q6A A;  5HI6 A;  3GHV A;  3FRE X;  3EIG A;  3F0S X;  2GD9 A;  1DAJ A;  1DR7 A;  5HQZ A;  4G3M A;  3K45 A;  3QLZ A;  1RX8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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