5DFRA

Crystal structure of unliganded escherichia coli dihydrofolate reductase. ligand-induced conformational changes and cooperativity in binding
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
159
structure length
154
Chain Sequence
MISLIAALAVDRVIGPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 40
structure length 154
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1988-10-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5dfrA00
3HJ3A 1JOLA 3DL6A 1M7AA 3JWMA 3F0VX 4X5IA 4KJKA 4ELHA 2XW7A 1DHIA 4KYAA 4EIZA 3K74A 2P4GA 1KMSA 2KGKA 2DHFA 2OIPA 5U27A 5FDAA 4HOFA 3KJRA 3UM5A 4QLEA 4X5JA 3NXRA 4M7UA 3KJSA 3SRRX 3NU0A 1RA3A 2L28A 1J3KA 1HFPA 4H98A 4EJ1A 3K45A 1CZ3A 1QZFA 1J3JA 3S3VA 2B3ZA 4KFJA 2W9TA 3F0UX 4LAEX 1OHJA 5CCCA 1DDSA 3FY8X 4ELFA 1RX3A 1RH3A 3TQAA 3FQ0A 3HBBA 5HT5A 1RD7A 3TQ9A 3EIGA 1U70A 4QLFA 1SEJA 7DFRA 4Q0DA 1E26A 5HSUA 3DATA 6DFRA 3SRWX 2HXVA 3NZ9X 3FRAX 4X5GA 1RA8A 1DR1A 1DRHA 4DFRA 2W3VA 3QGTA 4FGHA 1HFRA 1U71A 4M7VA 3DL5A 3EX8A 1DG7A 4RGCA 4EILA 5JG0X 1VDRA 1DAJA 4KBNA 2QK8A 3TQBA 1M79A 5HSRA 4KEBA 3I3RA 5CC9A 1OHKA 3NXTA 4PSTA 2BLAA 1J3IA 3FL8A 3CSEA 3KGYA 4M2XA 3D84X 1DR5A 1RB2A 5DXVA 4G3MA 3FRDX 4LEKX 1BOZA 3QLWA 3FYVX 4X5HA 3KFYA 1LY4A 2FZHA 3GHCA 4M6KA 1DLSA 2D0KA 4DPDA 2DRCA 1DF7A 4XECX 3F0BX 2W3BA 4QI9A 4I1NA 2D5NA 3SQYX 3ROAA 1DR7A 3QL3A 3IX9A 4OSGA 3FYWX 5HQYA 3SR5X 4DPHA 3GHWA 4QLGA 3FQFA 2ANOA 3ZPGA 3FREX 3QYOA 5ECCA 3QLYA 4XT8A 4PTHA 1YHOA 1DHFA 4HOGA 1DR6A 4P3RA 3IA4A 2CD2A 3QL0A 2OBCA 1DYIA 3F0QX 3EELA 3NXVA 3UM6A 3CLBA 3TQ8A 3M08A 1DDRA 3DFRA 3JW5A 3QLSA 3EEKA 2W3MA 4NX7A 4XT4A 2INQA 4KY8A 5HQZA 4IXGX 3GYFA 4KLXA 1DR4A 4Q67A 3SRSX 5HUIA 1DR3A 3K2HA 3EEMA 3EEJA 1KLKA 4IXED 5JA3A 4Q6AA 4FHBA 5EAJA 1AI9A 4ELGA 4M6JA 4Q0EA 1BZFA 3S9UA 1LUDA 3FQOA 2ZZAA 3FL9A 4HA9A 1S3VA 3QYLA 1DYHA 3E0BA 3IRNA 4KM0A 3SH2A 3S7AA 3CL9A 3FQVA 4LAHX 3NXXA 3NZ6X 1RA1A 1KMVA 3VCOA 4EIGA 1DLRA 1IA1A 3SRQX 1RX6A 2W9SA 3D80A 4ELBA 3NZDA 1RX5A 3OAFA 3SRUX 3FQCA 1RE7A 3JTWA 2GD9A 5ECXA 3FRBX 4CD2A 4PTJA 1IA4A 2C2SA 3GHVA 3F8ZA 1DIUA 1MVTA 4KJLA 4KY4A 3NZAX 3QLRA 1HFQA 2W3AA 3NZCX 4PDJA 3DG8A 4ECKA 1PD8A 4PSYA 2BL9A 3QLXA 1S3WA 3NTZA 2ITHA 3LG4A 3M09A 1DR2A 1DREA 4DP3A 4G8ZX 1RX7A 3NZBX 3RG9A 3L3RA 4P68A 4NX6A 1RA9A 3IROA 3F8YA 2W3WA 3NXOA 3SAIA 3RO9A 4KNEA 1RC4A 3JVXA 5DFRA 3INVA 1DHJA 4G95A 2FZJA 2H2QA 1DRFA 3Q1HA 2BLCA 4QJCA 4XT7A 1PD9A 1IA3A 3SA1A 4P66A 1CD2A 4OR7A 1MVSA 3R33A 3JWCA 4XT5A 4I13A 3F0SX 4ELEA 4P3QA 1DYRA 1RG7A 3FS6A 4KAKA 1RX1A 3NXYA 3FQZA 4TU5X 4QHVA 1RX4A 3JW3A 3SGYA 1M78A 3F91A 1S3YA 3TD8A 4LAGX 5E8QA 4M6LA 1DRAA 1JOMA 1IA2A 2G6VA 2W9HA 5HF0X 4H96A 1DG5A 5HT4A 5HF2X 3IA5A 2HQPA 1RF7A 1S3UA 2AZNA 4KL9A 2BLBA 1AOEA 3FY9X 3JWKA 4H97A 1DYJA 3JSUA 3QG2A 5HVBA 2LF1A 2CIGA 3OCHA 4HA7A 2ANQA 1TDRA 1VJ3A 3SA2A 3IRMA 1ZDRA 2C2TA 3KY8A 1D1GA 1JUVA 4X5FA 5HVEA 4KD7A 3QLZA 4XE6X 2JYBA 2O7PA 3GI2A 1RX2A 4GH8A 2FZIA 4QJZD 3DAUA 4KJJA 4FGGA 3QFXA 2HM9A 1AO8A 1PDBA 1U72A 3DGAA 3K47A 4DDRA 1DRBA 4XRBA 4XT6A 4KM2A 4PSSA 1DG8A 1RB3A 5HPBA 3DRCA 1DISA 3F0XX 3CD2A 8DFRA 5U26A 1RX8A 1LY3A 3JWFA 1RA2A 3N0HA 5HI6A 3FRFX 3I8AX 4IXFX 4HOEA 4H95A 3UM8A 2W9GA 3NRRA 3ZPCA 1RX9A
chains in the Genus database with same CATH superfamily
3HJ3A 1JOLA 3DL6A 1M7AA 3JWMA 3F0VX 4X5IA 4KJKA 4ELHA 2XW7A 1DHIA 4KYAA 4EIZA 3K74A 2P4GA 1KMSA 2KGKA 2DHFA 2OIPA 5U27A 5FDAA 4HOFA 3KJRA 3UM5A 4QLEA 4X5JA 3NXRA 4M7UA 3KJSA 3SRRX 3NU0A 1RA3A 2L28A 1J3KA 1HFPA 4H98A 4EJ1A 3K45A 1CZ3A 1QZFA 1J3JA 3S3VA 2B3ZA 4KFJA 2W9TA 3F0UX 4LAEX 1OHJA 5CCCA 1DDSA 3FY8X 4ELFA 1RX3A 1RH3A 3TQAA 3FQ0A 3HBBA 5HT5A 1RD7A 3TQ9A 3EIGA 1U70A 4QLFA 1SEJA 7DFRA 4Q0DA 1E26A 5HSUA 3DATA 6DFRA 3SRWX 2HXVA 3NZ9X 3FRAX 4X5GA 1RA8A 1DR1A 1DRHA 4DFRA 2W3VA 3QGTA 4FGHA 1HFRA 1U71A 4M7VA 3DL5A 3EX8A 1DG7A 4RGCA 4EILA 5JG0X 1VDRA 1DAJA 4KBNA 2QK8A 3TQBA 1M79A 5HSRA 4KEBA 3I3RA 5CC9A 1OHKA 3NXTA 4PSTA 2BLAA 1J3IA 3FL8A 3CSEA 3KGYA 4M2XA 3D84X 1DR5A 1RB2A 5DXVA 4G3MA 3FRDX 4LEKX 1BOZA 3QLWA 3FYVX 4X5HA 3KFYA 1LY4A 2FZHA 3GHCA 4M6KA 1DLSA 2D0KA 4DPDA 2DRCA 1DF7A 4XECX 3F0BX 2W3BA 4QI9A 4I1NA 2D5NA 3SQYX 3ROAA 1DR7A 3QL3A 3IX9A 4OSGA 3FYWX 5HQYA 3SR5X 4DPHA 3GHWA 4QLGA 3FQFA 2ANOA 3ZPGA 3FREX 3QYOA 5ECCA 3QLYA 4XT8A 4PTHA 1YHOA 1DHFA 4HOGA 1DR6A 4P3RA 3IA4A 2CD2A 3QL0A 2OBCA 1DYIA 3F0QX 3EELA 3NXVA 3UM6A 3CLBA 3TQ8A 3M08A 1DDRA 3DFRA 3JW5A 3QLSA 3EEKA 2W3MA 4NX7A 4XT4A 2INQA 4KY8A 5HQZA 4IXGX 3GYFA 4KLXA 1DR4A 4Q67A 3SRSX 5HUIA 1DR3A 3K2HA 3EEMA 3EEJA 1KLKA 4IXED 5JA3A 4Q6AA 4FHBA 5EAJA 1AI9A 4ELGA 4M6JA 4Q0EA 1BZFA 3S9UA 1LUDA 3FQOA 2ZZAA 3FL9A 4HA9A 1S3VA 3QYLA 1DYHA 3E0BA 3IRNA 4KM0A 3SH2A 3S7AA 3CL9A 3FQVA 4LAHX 3NXXA 3NZ6X 1RA1A 1KMVA 3VCOA 4EIGA 1DLRA 1IA1A 3SRQX 1RX6A 2W9SA 3D80A 4ELBA 3NZDA 1RX5A 3OAFA 3SRUX 3FQCA 1RE7A 3JTWA 2GD9A 5ECXA 3FRBX 4CD2A 4PTJA 1IA4A 2C2SA 3GHVA 3F8ZA 1DIUA 1MVTA 4KJLA 4KY4A 3NZAX 3QLRA 1HFQA 2W3AA 3NZCX 4PDJA 3DG8A 4ECKA 1PD8A 4PSYA 2BL9A 3QLXA 1S3WA 3NTZA 2ITHA 3LG4A 3M09A 1DR2A 1DREA 4DP3A 4G8ZX 1RX7A 3NZBX 3RG9A 3L3RA 4P68A 4NX6A 1RA9A 3IROA 3F8YA 2W3WA 3NXOA 3SAIA 3RO9A 4KNEA 1RC4A 3JVXA 5DFRA 3INVA 1DHJA 4G95A 2FZJA 2H2QA 1DRFA 3Q1HA 2BLCA 4QJCA 4XT7A 1PD9A 1IA3A 3SA1A 4P66A 1CD2A 4OR7A 1MVSA 3R33A 3JWCA 4XT5A 4I13A 3F0SX 4ELEA 4P3QA 1DYRA 1RG7A 3FS6A 4KAKA 1RX1A 3NXYA 3FQZA 4TU5X 4QHVA 1RX4A 3JW3A 3SGYA 1M78A 3F91A 1S3YA 3TD8A 4LAGX 5E8QA 4M6LA 1DRAA 1JOMA 1IA2A 2G6VA 2W9HA 5HF0X 4H96A 1DG5A 5HT4A 5HF2X 3IA5A 2HQPA 1RF7A 1S3UA 2AZNA 4KL9A 2BLBA 1AOEA 3FY9X 3JWKA 4H97A 1DYJA 3JSUA 3QG2A 5HVBA 2LF1A 2CIGA 3OCHA 4HA7A 2ANQA 1TDRA 1VJ3A 3SA2A 3IRMA 1ZDRA 2C2TA 3KY8A 1D1GA 1JUVA 4X5FA 5HVEA 4KD7A 3QLZA 4XE6X 2JYBA 2O7PA 3GI2A 1RX2A 4GH8A 2FZIA 4QJZD 3DAUA 4KJJA 4FGGA 3QFXA 2HM9A 1AO8A 1PDBA 1U72A 3DGAA 3K47A 4DDRA 1DRBA 4XRBA 4XT6A 4KM2A 4PSSA 1DG8A 1RB3A 5HPBA 3DRCA 1DISA 3F0XX 3CD2A 8DFRA 5U26A 1RX8A 1LY3A 3JWFA 1RA2A 3N0HA 5HI6A 3FRFX 3I8AX 4IXFX 4HOEA 4H95A 3UM8A 2W9GA 3NRRA 3ZPCA 1RX9A
chains in the Genus database with same CATH topology
3HJ3A 1JOLA 3DL6A 1M7AA 3JWMA 3F0VX 4X5IA 4KJKA 4ELHA 2XW7A 1DHIA 4KYAA 4EIZA 3K74A 2P4GA 1KMSA 2KGKA 2DHFA 2OIPA 5U27A 5FDAA 4HOFA 3KJRA 3UM5A 4QLEA 4X5JA 3NXRA 4M7UA 3KJSA 3SRRX 3NU0A 1RA3A 2L28A 1J3KA 1HFPA 4H98A 4EJ1A 3K45A 1CZ3A 1QZFA 1J3JA 3S3VA 2B3ZA 4KFJA 2W9TA 3F0UX 4LAEX 1OHJA 5CCCA 1DDSA 3FY8X 4ELFA 1RX3A 1RH3A 3TQAA 3FQ0A 3HBBA 5HT5A 1RD7A 3TQ9A 3EIGA 1U70A 4QLFA 1SEJA 7DFRA 4Q0DA 1E26A 5HSUA 3DATA 6DFRA 3SRWX 2HXVA 3NZ9X 3FRAX 4X5GA 1RA8A 1DR1A 1DRHA 4DFRA 2W3VA 3QGTA 4FGHA 1HFRA 1U71A 4M7VA 3DL5A 3EX8A 1DG7A 4RGCA 4EILA 5JG0X 1VDRA 1DAJA 4KBNA 2QK8A 3TQBA 1M79A 5HSRA 4KEBA 3I3RA 5CC9A 1OHKA 3NXTA 4PSTA 2BLAA 1J3IA 3FL8A 3CSEA 3KGYA 4M2XA 3D84X 1DR5A 1RB2A 5DXVA 4G3MA 3FRDX 4LEKX 1BOZA 3QLWA 3FYVX 4X5HA 3KFYA 1LY4A 2FZHA 3GHCA 4M6KA 1DLSA 2D0KA 4DPDA 2DRCA 1DF7A 4XECX 3F0BX 2W3BA 4QI9A 4I1NA 2D5NA 3SQYX 3ROAA 1DR7A 3QL3A 3IX9A 4OSGA 3FYWX 5HQYA 3SR5X 4DPHA 3GHWA 4QLGA 3FQFA 2ANOA 3ZPGA 3FREX 3QYOA 5ECCA 3QLYA 4XT8A 4PTHA 1YHOA 1DHFA 4HOGA 1DR6A 4P3RA 3IA4A 2CD2A 3QL0A 2OBCA 1DYIA 3F0QX 3EELA 3NXVA 3UM6A 3CLBA 3TQ8A 3M08A 1DDRA 3DFRA 3JW5A 3QLSA 3EEKA 2W3MA 4NX7A 4XT4A 2INQA 4KY8A 5HQZA 4IXGX 3GYFA 4KLXA 1DR4A 4Q67A 3SRSX 5HUIA 1DR3A 3K2HA 3EEMA 3EEJA 1KLKA 4IXED 5JA3A 4Q6AA 4FHBA 5EAJA 1AI9A 4ELGA 4M6JA 4Q0EA 1BZFA 3S9UA 1LUDA 3FQOA 2ZZAA 3FL9A 4HA9A 1S3VA 3QYLA 1DYHA 3E0BA 3IRNA 4KM0A 3SH2A 3S7AA 3CL9A 3FQVA 4LAHX 3NXXA 3NZ6X 1RA1A 1KMVA 3VCOA 4EIGA 1DLRA 1IA1A 3SRQX 1RX6A 2W9SA 3D80A 4ELBA 3NZDA 1RX5A 3OAFA 3SRUX 3FQCA 1RE7A 3JTWA 2GD9A 5ECXA 3FRBX 4CD2A 4PTJA 1IA4A 2C2SA 3GHVA 3F8ZA 1DIUA 1MVTA 4KJLA 4KY4A 3NZAX 3QLRA 1HFQA 2W3AA 3NZCX 4PDJA 3DG8A 4ECKA 1PD8A 4PSYA 2BL9A 3QLXA 1S3WA 3NTZA 2ITHA 3LG4A 3M09A 1DR2A 1DREA 4DP3A 4G8ZX 1RX7A 3NZBX 3RG9A 3L3RA 4P68A 4NX6A 1RA9A 3IROA 3F8YA 2W3WA 3NXOA 3SAIA 3RO9A 4KNEA 1RC4A 3JVXA 5DFRA 3INVA 1DHJA 4G95A 2FZJA 2H2QA 1DRFA 3Q1HA 2BLCA 4QJCA 4XT7A 1PD9A 1IA3A 3SA1A 4P66A 1CD2A 4OR7A 1MVSA 3R33A 3JWCA 4XT5A 4I13A 3F0SX 4ELEA 4P3QA 1DYRA 1RG7A 3FS6A 4KAKA 1RX1A 3NXYA 3FQZA 4TU5X 4QHVA 1RX4A 3JW3A 3SGYA 1M78A 3F91A 1S3YA 3TD8A 4LAGX 5E8QA 4M6LA 1DRAA 1JOMA 1IA2A 2G6VA 2W9HA 5HF0X 4H96A 1DG5A 5HT4A 5HF2X 3IA5A 2HQPA 1RF7A 1S3UA 2AZNA 4KL9A 2BLBA 1AOEA 3FY9X 3JWKA 4H97A 1DYJA 3JSUA 3QG2A 5HVBA 2LF1A 2CIGA 3OCHA 4HA7A 2ANQA 1TDRA 1VJ3A 3SA2A 3IRMA 1ZDRA 2C2TA 3KY8A 1D1GA 1JUVA 4X5FA 5HVEA 4KD7A 3QLZA 4XE6X 2JYBA 2O7PA 3GI2A 1RX2A 4GH8A 2FZIA 4QJZD 3DAUA 4KJJA 4FGGA 3QFXA 2HM9A 1AO8A 1PDBA 1U72A 3DGAA 3K47A 4DDRA 1DRBA 4XRBA 4XT6A 4KM2A 4PSSA 1DG8A 1RB3A 5HPBA 3DRCA 1DISA 3F0XX 3CD2A 8DFRA 5U26A 1RX8A 1LY3A 3JWFA 1RA2A 3N0HA 5HI6A 3FRFX 3I8AX 4IXFX 4HOEA 4H95A 3UM8A 2W9GA 3NRRA 3ZPCA 1RX9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HJ3 A;  1JOL A;  3DL6 A;  1M7A A;  3JWM A;  3F0V X;  4X5I A;  4KJK A;  4ELH A;  2XW7 A;  1DHI A;  4KYA A;  4EIZ A;  3K74 A;  2P4G A;  1KMS A;  2KGK A;  2DHF A;  2OIP A;  5U27 A;  5FDA A;  4HOF A;  3KJR A;  3UM5 A;  4QLE A;  4X5J A;  3NXR A;  4M7U A;  3KJS A;  3SRR X;  3NU0 A;  1RA3 A;  2L28 A;  1J3K A;  1HFP A;  4H98 A;  4EJ1 A;  3K45 A;  1CZ3 A;  1QZF A;  1J3J A;  3S3V A;  2B3Z A;  4KFJ A;  2W9T A;  3F0U X;  4LAE X;  1OHJ A;  5CCC A;  1DDS A;  3FY8 X;  4ELF A;  1RX3 A;  1RH3 A;  3TQA A;  3FQ0 A;  3HBB A;  5HT5 A;  1RD7 A;  3TQ9 A;  3EIG A;  1U70 A;  4QLF A;  1SEJ A;  7DFR A;  4Q0D A;  1E26 A;  5HSU A;  3DAT A;  6DFR A;  3SRW X;  2HXV A;  3NZ9 X;  3FRA X;  4X5G A;  1RA8 A;  1DR1 A;  1DRH A;  4DFR A;  2W3V A;  3QGT A;  4FGH A;  1HFR A;  1U71 A;  4M7V A;  3DL5 A;  3EX8 A;  1DG7 A;  4RGC A;  4EIL A;  5JG0 X;  1VDR A;  1DAJ A;  4KBN A;  2QK8 A;  3TQB A;  1M79 A;  5HSR A;  4KEB A;  3I3R A;  5CC9 A;  1OHK A;  3NXT A;  4PST A;  2BLA A;  1J3I A;  3FL8 A;  3CSE A;  3KGY A;  4M2X A;  3D84 X;  1DR5 A;  1RB2 A;  5DXV A;  4G3M A;  3FRD X;  4LEK X;  1BOZ A;  3QLW A;  3FYV X;  4X5H A;  3KFY A;  1LY4 A;  2FZH A;  3GHC A;  4M6K A;  1DLS A;  2D0K A;  4DPD A;  2DRC A;  1DF7 A;  4XEC X;  3F0B X;  2W3B A;  4QI9 A;  4I1N A;  2D5N A;  3SQY X;  3ROA A;  1DR7 A;  3QL3 A;  3IX9 A;  4OSG A;  3FYW X;  5HQY A;  3SR5 X;  4DPH A;  3GHW A;  4QLG A;  3FQF A;  2ANO A;  3ZPG A;  3FRE X;  3QYO A;  5ECC A;  3QLY A;  4XT8 A;  4PTH A;  1YHO A;  1DHF A;  4HOG A;  1DR6 A;  4P3R A;  3IA4 A;  2CD2 A;  3QL0 A;  2OBC A;  1DYI A;  3F0Q X;  3EEL A;  3NXV A;  3UM6 A;  3CLB A;  3TQ8 A;  3M08 A;  1DDR A;  3DFR A;  3JW5 A;  3QLS A;  3EEK A;  2W3M A;  4NX7 A;  4XT4 A;  2INQ A;  4KY8 A;  5HQZ A;  4IXG X;  3GYF A;  4KLX A;  1DR4 A;  4Q67 A;  3SRS X;  5HUI A;  1DR3 A;  3K2H A;  3EEM A;  3EEJ A;  1KLK A;  4IXE D;  5JA3 A;  4Q6A A;  4FHB A;  5EAJ A;  1AI9 A;  4ELG A;  4M6J A;  4Q0E A;  1BZF A;  3S9U A;  1LUD A;  3FQO A;  2ZZA A;  3FL9 A;  4HA9 A;  1S3V A;  3QYL A;  1DYH A;  3E0B A;  3IRN A;  4KM0 A;  3SH2 A;  3S7A A;  3CL9 A;  3FQV A;  4LAH X;  3NXX A;  3NZ6 X;  1RA1 A;  1KMV A;  3VCO A;  4EIG A;  1DLR A;  1IA1 A;  3SRQ X;  1RX6 A;  2W9S A;  3D80 A;  4ELB A;  3NZD A;  1RX5 A;  3OAF A;  3SRU X;  3FQC A;  1RE7 A;  3JTW A;  2GD9 A;  5ECX A;  3FRB X;  4CD2 A;  4PTJ A;  1IA4 A;  2C2S A;  3GHV A;  3F8Z A;  1DIU A;  1MVT A;  4KJL A;  4KY4 A;  3NZA X;  3QLR A;  1HFQ A;  2W3A A;  3NZC X;  4PDJ A;  3DG8 A;  4ECK A;  1PD8 A;  4PSY A;  2BL9 A;  3QLX A;  1S3W A;  3NTZ A;  2ITH A;  3LG4 A;  3M09 A;  1DR2 A;  1DRE A;  4DP3 A;  4G8Z X;  1RX7 A;  3NZB X;  3RG9 A;  3L3R A;  4P68 A;  4NX6 A;  1RA9 A;  3IRO A;  3F8Y A;  2W3W A;  3NXO A;  3SAI A;  3RO9 A;  4KNE A;  1RC4 A;  3JVX A;  5DFR A;  3INV A;  1DHJ A;  4G95 A;  2FZJ A;  2H2Q A;  1DRF A;  3Q1H A;  2BLC A;  4QJC A;  4XT7 A;  1PD9 A;  1IA3 A;  3SA1 A;  4P66 A;  1CD2 A;  4OR7 A;  1MVS A;  3R33 A;  3JWC A;  4XT5 A;  4I13 A;  3F0S X;  4ELE A;  4P3Q A;  1DYR A;  1RG7 A;  3FS6 A;  4KAK A;  1RX1 A;  3NXY A;  3FQZ A;  4TU5 X;  4QHV A;  1RX4 A;  3JW3 A;  3SGY A;  1M78 A;  3F91 A;  1S3Y A;  3TD8 A;  4LAG X;  5E8Q A;  4M6L A;  1DRA A;  1JOM A;  1IA2 A;  2G6V A;  2W9H A;  5HF0 X;  4H96 A;  1DG5 A;  5HT4 A;  5HF2 X;  3IA5 A;  2HQP A;  1RF7 A;  1S3U A;  2AZN A;  4KL9 A;  2BLB A;  1AOE A;  3FY9 X;  3JWK A;  4H97 A;  1DYJ A;  3JSU A;  3QG2 A;  5HVB A;  2LF1 A;  2CIG A;  3OCH A;  4HA7 A;  2ANQ A;  1TDR A;  1VJ3 A;  3SA2 A;  3IRM A;  1ZDR A;  2C2T A;  3KY8 A;  1D1G A;  1JUV A;  4X5F A;  5HVE A;  4KD7 A;  3QLZ A;  4XE6 X;  2JYB A;  2O7P A;  3GI2 A;  1RX2 A;  4GH8 A;  2FZI A;  4QJZ D;  3DAU A;  4KJJ A;  4FGG A;  3QFX A;  2HM9 A;  1AO8 A;  1PDB A;  1U72 A;  3DGA A;  3K47 A;  4DDR A;  1DRB A;  4XRB A;  4XT6 A;  4KM2 A;  4PSS A;  1DG8 A;  1RB3 A;  5HPB A;  3DRC A;  1DIS A;  3F0X X;  3CD2 A;  8DFR A;  5U26 A;  1RX8 A;  1LY3 A;  3JWF A;  1RA2 A;  3N0H A;  5HI6 A;  3FRF X;  3I8A X;  4IXF X;  4HOE A;  4H95 A;  3UM8 A;  2W9G A;  3NRR A;  3ZPC A;  1RX9 A; 
#chains in the Genus database with same CATH topology
 3HJ3 A;  1JOL A;  3DL6 A;  1M7A A;  3JWM A;  3F0V X;  4X5I A;  4KJK A;  4ELH A;  2XW7 A;  1DHI A;  4KYA A;  4EIZ A;  3K74 A;  2P4G A;  1KMS A;  2KGK A;  2DHF A;  2OIP A;  5U27 A;  5FDA A;  4HOF A;  3KJR A;  3UM5 A;  4QLE A;  4X5J A;  3NXR A;  4M7U A;  3KJS A;  3SRR X;  3NU0 A;  1RA3 A;  2L28 A;  1J3K A;  1HFP A;  4H98 A;  4EJ1 A;  3K45 A;  1CZ3 A;  1QZF A;  1J3J A;  3S3V A;  2B3Z A;  4KFJ A;  2W9T A;  3F0U X;  4LAE X;  1OHJ A;  5CCC A;  1DDS A;  3FY8 X;  4ELF A;  1RX3 A;  1RH3 A;  3TQA A;  3FQ0 A;  3HBB A;  5HT5 A;  1RD7 A;  3TQ9 A;  3EIG A;  1U70 A;  4QLF A;  1SEJ A;  7DFR A;  4Q0D A;  1E26 A;  5HSU A;  3DAT A;  6DFR A;  3SRW X;  2HXV A;  3NZ9 X;  3FRA X;  4X5G A;  1RA8 A;  1DR1 A;  1DRH A;  4DFR A;  2W3V A;  3QGT A;  4FGH A;  1HFR A;  1U71 A;  4M7V A;  3DL5 A;  3EX8 A;  1DG7 A;  4RGC A;  4EIL A;  5JG0 X;  1VDR A;  1DAJ A;  4KBN A;  2QK8 A;  3TQB A;  1M79 A;  5HSR A;  4KEB A;  3I3R A;  5CC9 A;  1OHK A;  3NXT A;  4PST A;  2BLA A;  1J3I A;  3FL8 A;  3CSE A;  3KGY A;  4M2X A;  3D84 X;  1DR5 A;  1RB2 A;  5DXV A;  4G3M A;  3FRD X;  4LEK X;  1BOZ A;  3QLW A;  3FYV X;  4X5H A;  3KFY A;  1LY4 A;  2FZH A;  3GHC A;  4M6K A;  1DLS A;  2D0K A;  4DPD A;  2DRC A;  1DF7 A;  4XEC X;  3F0B X;  2W3B A;  4QI9 A;  4I1N A;  2D5N A;  3SQY X;  3ROA A;  1DR7 A;  3QL3 A;  3IX9 A;  4OSG A;  3FYW X;  5HQY A;  3SR5 X;  4DPH A;  3GHW A;  4QLG A;  3FQF A;  2ANO A;  3ZPG A;  3FRE X;  3QYO A;  5ECC A;  3QLY A;  4XT8 A;  4PTH A;  1YHO A;  1DHF A;  4HOG A;  1DR6 A;  4P3R A;  3IA4 A;  2CD2 A;  3QL0 A;  2OBC A;  1DYI A;  3F0Q X;  3EEL A;  3NXV A;  3UM6 A;  3CLB A;  3TQ8 A;  3M08 A;  1DDR A;  3DFR A;  3JW5 A;  3QLS A;  3EEK A;  2W3M A;  4NX7 A;  4XT4 A;  2INQ A;  4KY8 A;  5HQZ A;  4IXG X;  3GYF A;  4KLX A;  1DR4 A;  4Q67 A;  3SRS X;  5HUI A;  1DR3 A;  3K2H A;  3EEM A;  3EEJ A;  1KLK A;  4IXE D;  5JA3 A;  4Q6A A;  4FHB A;  5EAJ A;  1AI9 A;  4ELG A;  4M6J A;  4Q0E A;  1BZF A;  3S9U A;  1LUD A;  3FQO A;  2ZZA A;  3FL9 A;  4HA9 A;  1S3V A;  3QYL A;  1DYH A;  3E0B A;  3IRN A;  4KM0 A;  3SH2 A;  3S7A A;  3CL9 A;  3FQV A;  4LAH X;  3NXX A;  3NZ6 X;  1RA1 A;  1KMV A;  3VCO A;  4EIG A;  1DLR A;  1IA1 A;  3SRQ X;  1RX6 A;  2W9S A;  3D80 A;  4ELB A;  3NZD A;  1RX5 A;  3OAF A;  3SRU X;  3FQC A;  1RE7 A;  3JTW A;  2GD9 A;  5ECX A;  3FRB X;  4CD2 A;  4PTJ A;  1IA4 A;  2C2S A;  3GHV A;  3F8Z A;  1DIU A;  1MVT A;  4KJL A;  4KY4 A;  3NZA X;  3QLR A;  1HFQ A;  2W3A A;  3NZC X;  4PDJ A;  3DG8 A;  4ECK A;  1PD8 A;  4PSY A;  2BL9 A;  3QLX A;  1S3W A;  3NTZ A;  2ITH A;  3LG4 A;  3M09 A;  1DR2 A;  1DRE A;  4DP3 A;  4G8Z X;  1RX7 A;  3NZB X;  3RG9 A;  3L3R A;  4P68 A;  4NX6 A;  1RA9 A;  3IRO A;  3F8Y A;  2W3W A;  3NXO A;  3SAI A;  3RO9 A;  4KNE A;  1RC4 A;  3JVX A;  5DFR A;  3INV A;  1DHJ A;  4G95 A;  2FZJ A;  2H2Q A;  1DRF A;  3Q1H A;  2BLC A;  4QJC A;  4XT7 A;  1PD9 A;  1IA3 A;  3SA1 A;  4P66 A;  1CD2 A;  4OR7 A;  1MVS A;  3R33 A;  3JWC A;  4XT5 A;  4I13 A;  3F0S X;  4ELE A;  4P3Q A;  1DYR A;  1RG7 A;  3FS6 A;  4KAK A;  1RX1 A;  3NXY A;  3FQZ A;  4TU5 X;  4QHV A;  1RX4 A;  3JW3 A;  3SGY A;  1M78 A;  3F91 A;  1S3Y A;  3TD8 A;  4LAG X;  5E8Q A;  4M6L A;  1DRA A;  1JOM A;  1IA2 A;  2G6V A;  2W9H A;  5HF0 X;  4H96 A;  1DG5 A;  5HT4 A;  5HF2 X;  3IA5 A;  2HQP A;  1RF7 A;  1S3U A;  2AZN A;  4KL9 A;  2BLB A;  1AOE A;  3FY9 X;  3JWK A;  4H97 A;  1DYJ A;  3JSU A;  3QG2 A;  5HVB A;  2LF1 A;  2CIG A;  3OCH A;  4HA7 A;  2ANQ A;  1TDR A;  1VJ3 A;  3SA2 A;  3IRM A;  1ZDR A;  2C2T A;  3KY8 A;  1D1G A;  1JUV A;  4X5F A;  5HVE A;  4KD7 A;  3QLZ A;  4XE6 X;  2JYB A;  2O7P A;  3GI2 A;  1RX2 A;  4GH8 A;  2FZI A;  4QJZ D;  3DAU A;  4KJJ A;  4FGG A;  3QFX A;  2HM9 A;  1AO8 A;  1PDB A;  1U72 A;  3DGA A;  3K47 A;  4DDR A;  1DRB A;  4XRB A;  4XT6 A;  4KM2 A;  4PSS A;  1DG8 A;  1RB3 A;  5HPB A;  3DRC A;  1DIS A;  3F0X X;  3CD2 A;  8DFR A;  5U26 A;  1RX8 A;  1LY3 A;  3JWF A;  1RA2 A;  3N0H A;  5HI6 A;  3FRF X;  3I8A X;  4IXF X;  4HOE A;  4H95 A;  3UM8 A;  2W9G A;  3NRR A;  3ZPC A;  1RX9 A; 
#chains in the Genus database with same CATH homology
 3HJ3 A;  1JOL A;  3DL6 A;  1M7A A;  3JWM A;  3F0V X;  4X5I A;  4KJK A;  4ELH A;  2XW7 A;  1DHI A;  4KYA A;  4EIZ A;  3K74 A;  2P4G A;  1KMS A;  2KGK A;  2DHF A;  2OIP A;  5U27 A;  5FDA A;  4HOF A;  3KJR A;  3UM5 A;  4QLE A;  4X5J A;  3NXR A;  4M7U A;  3KJS A;  3SRR X;  3NU0 A;  1RA3 A;  2L28 A;  1J3K A;  1HFP A;  4H98 A;  4EJ1 A;  3K45 A;  1CZ3 A;  1QZF A;  1J3J A;  3S3V A;  2B3Z A;  4KFJ A;  2W9T A;  3F0U X;  4LAE X;  1OHJ A;  5CCC A;  1DDS A;  3FY8 X;  4ELF A;  1RX3 A;  1RH3 A;  3TQA A;  3FQ0 A;  3HBB A;  5HT5 A;  1RD7 A;  3TQ9 A;  3EIG A;  1U70 A;  4QLF A;  1SEJ A;  7DFR A;  4Q0D A;  1E26 A;  5HSU A;  3DAT A;  6DFR A;  3SRW X;  2HXV A;  3NZ9 X;  3FRA X;  4X5G A;  1RA8 A;  1DR1 A;  1DRH A;  4DFR A;  2W3V A;  3QGT A;  4FGH A;  1HFR A;  1U71 A;  4M7V A;  3DL5 A;  3EX8 A;  1DG7 A;  4RGC A;  4EIL A;  5JG0 X;  1VDR A;  1DAJ A;  4KBN A;  2QK8 A;  3TQB A;  1M79 A;  5HSR A;  4KEB A;  3I3R A;  5CC9 A;  1OHK A;  3NXT A;  4PST A;  2BLA A;  1J3I A;  3FL8 A;  3CSE A;  3KGY A;  4M2X A;  3D84 X;  1DR5 A;  1RB2 A;  5DXV A;  4G3M A;  3FRD X;  4LEK X;  1BOZ A;  3QLW A;  3FYV X;  4X5H A;  3KFY A;  1LY4 A;  2FZH A;  3GHC A;  4M6K A;  1DLS A;  2D0K A;  4DPD A;  2DRC A;  1DF7 A;  4XEC X;  3F0B X;  2W3B A;  4QI9 A;  4I1N A;  2D5N A;  3SQY X;  3ROA A;  1DR7 A;  3QL3 A;  3IX9 A;  4OSG A;  3FYW X;  5HQY A;  3SR5 X;  4DPH A;  3GHW A;  4QLG A;  3FQF A;  2ANO A;  3ZPG A;  3FRE X;  3QYO A;  5ECC A;  3QLY A;  4XT8 A;  4PTH A;  1YHO A;  1DHF A;  4HOG A;  1DR6 A;  4P3R A;  3IA4 A;  2CD2 A;  3QL0 A;  2OBC A;  1DYI A;  3F0Q X;  3EEL A;  3NXV A;  3UM6 A;  3CLB A;  3TQ8 A;  3M08 A;  1DDR A;  3DFR A;  3JW5 A;  3QLS A;  3EEK A;  2W3M A;  4NX7 A;  4XT4 A;  2INQ A;  4KY8 A;  5HQZ A;  4IXG X;  3GYF A;  4KLX A;  1DR4 A;  4Q67 A;  3SRS X;  5HUI A;  1DR3 A;  3K2H A;  3EEM A;  3EEJ A;  1KLK A;  4IXE D;  5JA3 A;  4Q6A A;  4FHB A;  5EAJ A;  1AI9 A;  4ELG A;  4M6J A;  4Q0E A;  1BZF A;  3S9U A;  1LUD A;  3FQO A;  2ZZA A;  3FL9 A;  4HA9 A;  1S3V A;  3QYL A;  1DYH A;  3E0B A;  3IRN A;  4KM0 A;  3SH2 A;  3S7A A;  3CL9 A;  3FQV A;  4LAH X;  3NXX A;  3NZ6 X;  1RA1 A;  1KMV A;  3VCO A;  4EIG A;  1DLR A;  1IA1 A;  3SRQ X;  1RX6 A;  2W9S A;  3D80 A;  4ELB A;  3NZD A;  1RX5 A;  3OAF A;  3SRU X;  3FQC A;  1RE7 A;  3JTW A;  2GD9 A;  5ECX A;  3FRB X;  4CD2 A;  4PTJ A;  1IA4 A;  2C2S A;  3GHV A;  3F8Z A;  1DIU A;  1MVT A;  4KJL A;  4KY4 A;  3NZA X;  3QLR A;  1HFQ A;  2W3A A;  3NZC X;  4PDJ A;  3DG8 A;  4ECK A;  1PD8 A;  4PSY A;  2BL9 A;  3QLX A;  1S3W A;  3NTZ A;  2ITH A;  3LG4 A;  3M09 A;  1DR2 A;  1DRE A;  4DP3 A;  4G8Z X;  1RX7 A;  3NZB X;  3RG9 A;  3L3R A;  4P68 A;  4NX6 A;  1RA9 A;  3IRO A;  3F8Y A;  2W3W A;  3NXO A;  3SAI A;  3RO9 A;  4KNE A;  1RC4 A;  3JVX A;  5DFR A;  3INV A;  1DHJ A;  4G95 A;  2FZJ A;  2H2Q A;  1DRF A;  3Q1H A;  2BLC A;  4QJC A;  4XT7 A;  1PD9 A;  1IA3 A;  3SA1 A;  4P66 A;  1CD2 A;  4OR7 A;  1MVS A;  3R33 A;  3JWC A;  4XT5 A;  4I13 A;  3F0S X;  4ELE A;  4P3Q A;  1DYR A;  1RG7 A;  3FS6 A;  4KAK A;  1RX1 A;  3NXY A;  3FQZ A;  4TU5 X;  4QHV A;  1RX4 A;  3JW3 A;  3SGY A;  1M78 A;  3F91 A;  1S3Y A;  3TD8 A;  4LAG X;  5E8Q A;  4M6L A;  1DRA A;  1JOM A;  1IA2 A;  2G6V A;  2W9H A;  5HF0 X;  4H96 A;  1DG5 A;  5HT4 A;  5HF2 X;  3IA5 A;  2HQP A;  1RF7 A;  1S3U A;  2AZN A;  4KL9 A;  2BLB A;  1AOE A;  3FY9 X;  3JWK A;  4H97 A;  1DYJ A;  3JSU A;  3QG2 A;  5HVB A;  2LF1 A;  2CIG A;  3OCH A;  4HA7 A;  2ANQ A;  1TDR A;  1VJ3 A;  3SA2 A;  3IRM A;  1ZDR A;  2C2T A;  3KY8 A;  1D1G A;  1JUV A;  4X5F A;  5HVE A;  4KD7 A;  3QLZ A;  4XE6 X;  2JYB A;  2O7P A;  3GI2 A;  1RX2 A;  4GH8 A;  2FZI A;  4QJZ D;  3DAU A;  4KJJ A;  4FGG A;  3QFX A;  2HM9 A;  1AO8 A;  1PDB A;  1U72 A;  3DGA A;  3K47 A;  4DDR A;  1DRB A;  4XRB A;  4XT6 A;  4KM2 A;  4PSS A;  1DG8 A;  1RB3 A;  5HPB A;  3DRC A;  1DIS A;  3F0X X;  3CD2 A;  8DFR A;  5U26 A;  1RX8 A;  1LY3 A;  3JWF A;  1RA2 A;  3N0H A;  5HI6 A;  3FRF X;  3I8A X;  4IXF X;  4HOE A;  4H95 A;  3UM8 A;  2W9G A;  3NRR A;  3ZPC A;  1RX9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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