5HUIA

6-substituted pyrido[3,2-d]pyrimidine--6-4'-trifluoromethoxyphenyl)
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Human dihydrofolate reductase ternary complex with a series of 6-substituted pyrido[3,2]pyrimidine-6-(4'-trifluoromethoxypheny)-2,4-diamines
rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 53
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-01-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5huiA00
3NXRA 2XW7A 1IA1A 4FHBA 1YHOA 2W9SA 1J3KA 3L3RA 3RO9A 1AOEA 1J3IA 4EIZA 1RE7A 4Q0EA 4KM0A 5FDAA 2QK8A 4X5HA 3SH2A 3KY8A 4PSTA 1IA3A 4PDJA 2C2SA 2JYBA 1RA1A 4Q0DA 4ELBA 3QLYA 3DG8A 3DFRA 4P66A 4EILA 3QLZA 2G6VA 2O7PA 1J3JA 3M08A 5EAJA 4CD2A 4KJLA 5ECCA 4XT5A 3SRQX 1KLKA 1DG7A 3F0SX 3SA1A 4QLGA 4P3RA 1RX4A 4KL9A 3KFYA 3EEMA 1HFRA 4LAEX 3KJSA 4DFRA 3NU0A 5HI6A 4H98A 1RX3A 2FZIA 1CZ3A 3EIGA 3RG9A 3FYVX 4QJZD 3NZAX 4XT8A 1JUVA 4DP3A 4P3QA 4X5JA 4LAGX 3HJ3A 1E26A 3DL6A 1U70A 1OHJA 1DG5A 3JSUA 4M7VA 4ELFA 1LY3A 3FQZA 5DXVA 4XECX 3KJRA 3TQAA 4DPDA 4KYAA 1DF7A 4Q67A 3TQBA 1MVTA 1U71A 1S3VA 4X5FA 3JWKA 2W3AA 2ITHA 1DIUA 3SRWX 3N0HA 5HQZA 4QI9A 1S3UA 5HQYA 1BZFA 1OHKA 1RA3A 1JOLA 1VJ3A 1DDSA 3I8AX 2L28A 4KLXA 3IRNA 6DFRA 4PSYA 1DR6A 5HSRA 4DPHA 2ZZAA 1ZDRA 2INQA 1IA2A 2ANQA 3SR5X 4EJ1A 3NXYA 4KBNA 1HFQA 2BLBA 4G3MA 4M6JA 3FL8A 3FL9A 2DRCA 1DREA 4M6LA 3FRBX 3FREX 1U72A 3K47A 1PD9A 3FQFA 1DRFA 3QLXA 4NX6A 3GHWA 5JA3A 1RD7A 5E8QA 4QLEA 2CD2A 4XE6X 4H95A 8DFRA 3GYFA 3SA2A 5HVEA 2HXVA 1RB2A 3IROA 1DLRA 5ECXA 3FYWX 3UM8A 4LAHX 2ANOA 4HA9A 4KNEA 1VDRA 3SGYA 3FRAX 4XT6A 3QYOA 1RX9A 3JWCA 4RGCA 1D1GA 1RX1A 2H2QA 3EX8A 1DR1A 3HBBA 3DAUA 1DR4A 4OSGA 3QLWA 1DAJA 1RG7A 2BL9A 3F0UX 4XRBA 3F8ZA 1DISA 3S9UA 4M2XA 4GH8A 4KM2A 3EELA 2W3VA 4KJJA 1DYRA 2C2TA 2BLAA 3GHCA 1RC4A 1DG8A 1KMVA 4LEKX 5HSUA 4HOFA 3FQCA 3FRDX 3S7AA 3NXTA 3NXOA 2OBCA 1DYIA 3JWMA 1QZFA 3NRRA 4IXED 3K45A 4DDRA 1CD2A 1M7AA 3QG2A 1LUDA 4XT7A 1DRAA 3CD2A 1S3WA 3OCHA 3DRCA 3NXVA 3FQOA 3K74A 3JW5A 3QLSA 3S3VA 3UM6A 3FS6A 3FQ0A 3CLBA 4QJCA 2GD9A 4PTJA 3IA5A 1RF7A 4H96A 3FY8X 5JG0X 3NZBX 3FRFX 1DRHA 1DR5A 4M6KA 4H97A 1KMSA 4QHVA 3ZPCA 1RA2A 2HM9A 3SQYX 3DATA 3FQVA 4P68A 3IX9A 2W9TA 4HOGA 3QL0A 4KAKA 4QLFA 2FZHA 4Q6AA 3QYLA 4TU5X 2W3MA 5DFRA 2BLCA 4G95A 3K2HA 3I3RA 4KFJA 2D0KA 3JVXA 4G8ZX 3F91A 3OAFA 5CCCA 1S3YA 3ZPGA 1DHJA 4I1NA 4KY4A 3TQ8A 2DHFA 5HT5A 4M7UA 2W3BA 4X5GA 3IA4A 3F0XX 3M09A 1DR3A 4IXFX 1DHFA 5HF2X 4ECKA 4PSSA 4FGGA 2W9HA 3GI2A 3SAIA 1RX6A 3D84X 3CL9A 1DYJA 1PD8A 1RB3A 2AZNA 3F0VX 4I13A 4ELGA 1HFPA 3KGYA 2LF1A 1RX7A 3LG4A 1IA4A 4FGHA 2FZJA 1RA9A 1RX8A 1RH3A 5CC9A 3NZCX 1M78A 4KD7A 1DR2A 1DLSA 5HUIA 1RX2A 1TDRA 7DFRA 3R33A 2W3WA 4KEBA 3QGTA 5HPBA 3NZ9X 4XT4A 3GHVA 1M79A 2D5NA 3JWFA 3F0QX 3NXXA 2OIPA 1DRBA 3DL5A 3JTWA 1LY4A 3UM5A 4X5IA 3Q1HA 1AI9A 3CSEA 3F0BX 4EIGA 3TQ9A 2P4GA 1DR7A 3E0BA 3QFXA 3QLRA 2W9GA 2CIGA 3FY9X 5HF0X 1JOMA 3F8YA 4HA7A 1SEJA 3EEJA 3JW3A 3EEKA 4NX7A 3NTZA 4ELEA 3SRSX 1PDBA 3INVA 5HVBA 4OR7A 1BOZA 2B3ZA 5U27A 3ROAA 3TD8A 3D80A 4ELHA 3SRUX 5U26A 3NZDA 1MVSA 1DDRA 4PTHA 4HOEA 4IXGX 1DYHA 3VCOA 1AO8A 3DGAA 2HQPA 3SRRX 3QL3A 4KJKA 1DHIA 5HT4A 3IRMA 1RA8A 1RX5A 4KY8A 3NZ6X 2KGKA
chains in the Genus database with same CATH superfamily
3NXRA 2XW7A 1IA1A 4FHBA 1YHOA 2W9SA 1J3KA 3L3RA 3RO9A 1AOEA 1J3IA 4EIZA 1RE7A 4Q0EA 4KM0A 5FDAA 2QK8A 4X5HA 3SH2A 3KY8A 4PSTA 1IA3A 4PDJA 2C2SA 2JYBA 1RA1A 4Q0DA 4ELBA 3QLYA 3DG8A 3DFRA 4P66A 4EILA 3QLZA 2G6VA 2O7PA 1J3JA 3M08A 5EAJA 4CD2A 4KJLA 5ECCA 4XT5A 3SRQX 1KLKA 1DG7A 3F0SX 3SA1A 4QLGA 4P3RA 1RX4A 4KL9A 3KFYA 3EEMA 1HFRA 4LAEX 3KJSA 4DFRA 3NU0A 5HI6A 4H98A 1RX3A 2FZIA 1CZ3A 3EIGA 3RG9A 3FYVX 4QJZD 3NZAX 4XT8A 1JUVA 4DP3A 4P3QA 4X5JA 4LAGX 3HJ3A 1E26A 3DL6A 1U70A 1OHJA 1DG5A 3JSUA 4M7VA 4ELFA 1LY3A 3FQZA 5DXVA 4XECX 3KJRA 3TQAA 4DPDA 4KYAA 1DF7A 4Q67A 3TQBA 1MVTA 1U71A 1S3VA 4X5FA 3JWKA 2W3AA 2ITHA 1DIUA 3SRWX 3N0HA 5HQZA 4QI9A 1S3UA 5HQYA 1BZFA 1OHKA 1RA3A 1JOLA 1VJ3A 1DDSA 3I8AX 2L28A 4KLXA 3IRNA 6DFRA 4PSYA 1DR6A 5HSRA 4DPHA 2ZZAA 1ZDRA 2INQA 1IA2A 2ANQA 3SR5X 4EJ1A 3NXYA 4KBNA 1HFQA 2BLBA 4G3MA 4M6JA 3FL8A 3FL9A 2DRCA 1DREA 4M6LA 3FRBX 3FREX 1U72A 3K47A 1PD9A 3FQFA 1DRFA 3QLXA 4NX6A 3GHWA 5JA3A 1RD7A 5E8QA 4QLEA 2CD2A 4XE6X 4H95A 8DFRA 3GYFA 3SA2A 5HVEA 2HXVA 1RB2A 3IROA 1DLRA 5ECXA 3FYWX 3UM8A 4LAHX 2ANOA 4HA9A 4KNEA 1VDRA 3SGYA 3FRAX 4XT6A 3QYOA 1RX9A 3JWCA 4RGCA 1D1GA 1RX1A 2H2QA 3EX8A 1DR1A 3HBBA 3DAUA 1DR4A 4OSGA 3QLWA 1DAJA 1RG7A 2BL9A 3F0UX 4XRBA 3F8ZA 1DISA 3S9UA 4M2XA 4GH8A 4KM2A 3EELA 2W3VA 4KJJA 1DYRA 2C2TA 2BLAA 3GHCA 1RC4A 1DG8A 1KMVA 4LEKX 5HSUA 4HOFA 3FQCA 3FRDX 3S7AA 3NXTA 3NXOA 2OBCA 1DYIA 3JWMA 1QZFA 3NRRA 4IXED 3K45A 4DDRA 1CD2A 1M7AA 3QG2A 1LUDA 4XT7A 1DRAA 3CD2A 1S3WA 3OCHA 3DRCA 3NXVA 3FQOA 3K74A 3JW5A 3QLSA 3S3VA 3UM6A 3FS6A 3FQ0A 3CLBA 4QJCA 2GD9A 4PTJA 3IA5A 1RF7A 4H96A 3FY8X 5JG0X 3NZBX 3FRFX 1DRHA 1DR5A 4M6KA 4H97A 1KMSA 4QHVA 3ZPCA 1RA2A 2HM9A 3SQYX 3DATA 3FQVA 4P68A 3IX9A 2W9TA 4HOGA 3QL0A 4KAKA 4QLFA 2FZHA 4Q6AA 3QYLA 4TU5X 2W3MA 5DFRA 2BLCA 4G95A 3K2HA 3I3RA 4KFJA 2D0KA 3JVXA 4G8ZX 3F91A 3OAFA 5CCCA 1S3YA 3ZPGA 1DHJA 4I1NA 4KY4A 3TQ8A 2DHFA 5HT5A 4M7UA 2W3BA 4X5GA 3IA4A 3F0XX 3M09A 1DR3A 4IXFX 1DHFA 5HF2X 4ECKA 4PSSA 4FGGA 2W9HA 3GI2A 3SAIA 1RX6A 3D84X 3CL9A 1DYJA 1PD8A 1RB3A 2AZNA 3F0VX 4I13A 4ELGA 1HFPA 3KGYA 2LF1A 1RX7A 3LG4A 1IA4A 4FGHA 2FZJA 1RA9A 1RX8A 1RH3A 5CC9A 3NZCX 1M78A 4KD7A 1DR2A 1DLSA 5HUIA 1RX2A 1TDRA 7DFRA 3R33A 2W3WA 4KEBA 3QGTA 5HPBA 3NZ9X 4XT4A 3GHVA 1M79A 2D5NA 3JWFA 3F0QX 3NXXA 2OIPA 1DRBA 3DL5A 3JTWA 1LY4A 3UM5A 4X5IA 3Q1HA 1AI9A 3CSEA 3F0BX 4EIGA 3TQ9A 2P4GA 1DR7A 3E0BA 3QFXA 3QLRA 2W9GA 2CIGA 3FY9X 5HF0X 1JOMA 3F8YA 4HA7A 1SEJA 3EEJA 3JW3A 3EEKA 4NX7A 3NTZA 4ELEA 3SRSX 1PDBA 3INVA 5HVBA 4OR7A 1BOZA 2B3ZA 5U27A 3ROAA 3TD8A 3D80A 4ELHA 3SRUX 5U26A 3NZDA 1MVSA 1DDRA 4PTHA 4HOEA 4IXGX 1DYHA 3VCOA 1AO8A 3DGAA 2HQPA 3SRRX 3QL3A 4KJKA 1DHIA 5HT4A 3IRMA 1RA8A 1RX5A 4KY8A 3NZ6X 2KGKA
chains in the Genus database with same CATH topology
3NXRA 2XW7A 1IA1A 4FHBA 1YHOA 2W9SA 1J3KA 3L3RA 3RO9A 1AOEA 1J3IA 4EIZA 1RE7A 4Q0EA 4KM0A 5FDAA 2QK8A 4X5HA 3SH2A 3KY8A 4PSTA 1IA3A 4PDJA 2C2SA 2JYBA 1RA1A 4Q0DA 4ELBA 3QLYA 3DG8A 3DFRA 4P66A 4EILA 3QLZA 2G6VA 2O7PA 1J3JA 3M08A 5EAJA 4CD2A 4KJLA 5ECCA 4XT5A 3SRQX 1KLKA 1DG7A 3F0SX 3SA1A 4QLGA 4P3RA 1RX4A 4KL9A 3KFYA 3EEMA 1HFRA 4LAEX 3KJSA 4DFRA 3NU0A 5HI6A 4H98A 1RX3A 2FZIA 1CZ3A 3EIGA 3RG9A 3FYVX 4QJZD 3NZAX 4XT8A 1JUVA 4DP3A 4P3QA 4X5JA 4LAGX 3HJ3A 1E26A 3DL6A 1U70A 1OHJA 1DG5A 3JSUA 4M7VA 4ELFA 1LY3A 3FQZA 5DXVA 4XECX 3KJRA 3TQAA 4DPDA 4KYAA 1DF7A 4Q67A 3TQBA 1MVTA 1U71A 1S3VA 4X5FA 3JWKA 2W3AA 2ITHA 1DIUA 3SRWX 3N0HA 5HQZA 4QI9A 1S3UA 5HQYA 1BZFA 1OHKA 1RA3A 1JOLA 1VJ3A 1DDSA 3I8AX 2L28A 4KLXA 3IRNA 6DFRA 4PSYA 1DR6A 5HSRA 4DPHA 2ZZAA 1ZDRA 2INQA 1IA2A 2ANQA 3SR5X 4EJ1A 3NXYA 4KBNA 1HFQA 2BLBA 4G3MA 4M6JA 3FL8A 3FL9A 2DRCA 1DREA 4M6LA 3FRBX 3FREX 1U72A 3K47A 1PD9A 3FQFA 1DRFA 3QLXA 4NX6A 3GHWA 5JA3A 1RD7A 5E8QA 4QLEA 2CD2A 4XE6X 4H95A 8DFRA 3GYFA 3SA2A 5HVEA 2HXVA 1RB2A 3IROA 1DLRA 5ECXA 3FYWX 3UM8A 4LAHX 2ANOA 4HA9A 4KNEA 1VDRA 3SGYA 3FRAX 4XT6A 3QYOA 1RX9A 3JWCA 4RGCA 1D1GA 1RX1A 2H2QA 3EX8A 1DR1A 3HBBA 3DAUA 1DR4A 4OSGA 3QLWA 1DAJA 1RG7A 2BL9A 3F0UX 4XRBA 3F8ZA 1DISA 3S9UA 4M2XA 4GH8A 4KM2A 3EELA 2W3VA 4KJJA 1DYRA 2C2TA 2BLAA 3GHCA 1RC4A 1DG8A 1KMVA 4LEKX 5HSUA 4HOFA 3FQCA 3FRDX 3S7AA 3NXTA 3NXOA 2OBCA 1DYIA 3JWMA 1QZFA 3NRRA 4IXED 3K45A 4DDRA 1CD2A 1M7AA 3QG2A 1LUDA 4XT7A 1DRAA 3CD2A 1S3WA 3OCHA 3DRCA 3NXVA 3FQOA 3K74A 3JW5A 3QLSA 3S3VA 3UM6A 3FS6A 3FQ0A 3CLBA 4QJCA 2GD9A 4PTJA 3IA5A 1RF7A 4H96A 3FY8X 5JG0X 3NZBX 3FRFX 1DRHA 1DR5A 4M6KA 4H97A 1KMSA 4QHVA 3ZPCA 1RA2A 2HM9A 3SQYX 3DATA 3FQVA 4P68A 3IX9A 2W9TA 4HOGA 3QL0A 4KAKA 4QLFA 2FZHA 4Q6AA 3QYLA 4TU5X 2W3MA 5DFRA 2BLCA 4G95A 3K2HA 3I3RA 4KFJA 2D0KA 3JVXA 4G8ZX 3F91A 3OAFA 5CCCA 1S3YA 3ZPGA 1DHJA 4I1NA 4KY4A 3TQ8A 2DHFA 5HT5A 4M7UA 2W3BA 4X5GA 3IA4A 3F0XX 3M09A 1DR3A 4IXFX 1DHFA 5HF2X 4ECKA 4PSSA 4FGGA 2W9HA 3GI2A 3SAIA 1RX6A 3D84X 3CL9A 1DYJA 1PD8A 1RB3A 2AZNA 3F0VX 4I13A 4ELGA 1HFPA 3KGYA 2LF1A 1RX7A 3LG4A 1IA4A 4FGHA 2FZJA 1RA9A 1RX8A 1RH3A 5CC9A 3NZCX 1M78A 4KD7A 1DR2A 1DLSA 5HUIA 1RX2A 1TDRA 7DFRA 3R33A 2W3WA 4KEBA 3QGTA 5HPBA 3NZ9X 4XT4A 3GHVA 1M79A 2D5NA 3JWFA 3F0QX 3NXXA 2OIPA 1DRBA 3DL5A 3JTWA 1LY4A 3UM5A 4X5IA 3Q1HA 1AI9A 3CSEA 3F0BX 4EIGA 3TQ9A 2P4GA 1DR7A 3E0BA 3QFXA 3QLRA 2W9GA 2CIGA 3FY9X 5HF0X 1JOMA 3F8YA 4HA7A 1SEJA 3EEJA 3JW3A 3EEKA 4NX7A 3NTZA 4ELEA 3SRSX 1PDBA 3INVA 5HVBA 4OR7A 1BOZA 2B3ZA 5U27A 3ROAA 3TD8A 3D80A 4ELHA 3SRUX 5U26A 3NZDA 1MVSA 1DDRA 4PTHA 4HOEA 4IXGX 1DYHA 3VCOA 1AO8A 3DGAA 2HQPA 3SRRX 3QL3A 4KJKA 1DHIA 5HT4A 3IRMA 1RA8A 1RX5A 4KY8A 3NZ6X 2KGKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NXR A;  2XW7 A;  1IA1 A;  4FHB A;  1YHO A;  2W9S A;  1J3K A;  3L3R A;  3RO9 A;  1AOE A;  1J3I A;  4EIZ A;  1RE7 A;  4Q0E A;  4KM0 A;  5FDA A;  2QK8 A;  4X5H A;  3SH2 A;  3KY8 A;  4PST A;  1IA3 A;  4PDJ A;  2C2S A;  2JYB A;  1RA1 A;  4Q0D A;  4ELB A;  3QLY A;  3DG8 A;  3DFR A;  4P66 A;  4EIL A;  3QLZ A;  2G6V A;  2O7P A;  1J3J A;  3M08 A;  5EAJ A;  4CD2 A;  4KJL A;  5ECC A;  4XT5 A;  3SRQ X;  1KLK A;  1DG7 A;  3F0S X;  3SA1 A;  4QLG A;  4P3R A;  1RX4 A;  4KL9 A;  3KFY A;  3EEM A;  1HFR A;  4LAE X;  3KJS A;  4DFR A;  3NU0 A;  5HI6 A;  4H98 A;  1RX3 A;  2FZI A;  1CZ3 A;  3EIG A;  3RG9 A;  3FYV X;  4QJZ D;  3NZA X;  4XT8 A;  1JUV A;  4DP3 A;  4P3Q A;  4X5J A;  4LAG X;  3HJ3 A;  1E26 A;  3DL6 A;  1U70 A;  1OHJ A;  1DG5 A;  3JSU A;  4M7V A;  4ELF A;  1LY3 A;  3FQZ A;  5DXV A;  4XEC X;  3KJR A;  3TQA A;  4DPD A;  4KYA A;  1DF7 A;  4Q67 A;  3TQB A;  1MVT A;  1U71 A;  1S3V A;  4X5F A;  3JWK A;  2W3A A;  2ITH A;  1DIU A;  3SRW X;  3N0H A;  5HQZ A;  4QI9 A;  1S3U A;  5HQY A;  1BZF A;  1OHK A;  1RA3 A;  1JOL A;  1VJ3 A;  1DDS A;  3I8A X;  2L28 A;  4KLX A;  3IRN A;  6DFR A;  4PSY A;  1DR6 A;  5HSR A;  4DPH A;  2ZZA A;  1ZDR A;  2INQ A;  1IA2 A;  2ANQ A;  3SR5 X;  4EJ1 A;  3NXY A;  4KBN A;  1HFQ A;  2BLB A;  4G3M A;  4M6J A;  3FL8 A;  3FL9 A;  2DRC A;  1DRE A;  4M6L A;  3FRB X;  3FRE X;  1U72 A;  3K47 A;  1PD9 A;  3FQF A;  1DRF A;  3QLX A;  4NX6 A;  3GHW A;  5JA3 A;  1RD7 A;  5E8Q A;  4QLE A;  2CD2 A;  4XE6 X;  4H95 A;  8DFR A;  3GYF A;  3SA2 A;  5HVE A;  2HXV A;  1RB2 A;  3IRO A;  1DLR A;  5ECX A;  3FYW X;  3UM8 A;  4LAH X;  2ANO A;  4HA9 A;  4KNE A;  1VDR A;  3SGY A;  3FRA X;  4XT6 A;  3QYO A;  1RX9 A;  3JWC A;  4RGC A;  1D1G A;  1RX1 A;  2H2Q A;  3EX8 A;  1DR1 A;  3HBB A;  3DAU A;  1DR4 A;  4OSG A;  3QLW A;  1DAJ A;  1RG7 A;  2BL9 A;  3F0U X;  4XRB A;  3F8Z A;  1DIS A;  3S9U A;  4M2X A;  4GH8 A;  4KM2 A;  3EEL A;  2W3V A;  4KJJ A;  1DYR A;  2C2T A;  2BLA A;  3GHC A;  1RC4 A;  1DG8 A;  1KMV A;  4LEK X;  5HSU A;  4HOF A;  3FQC A;  3FRD X;  3S7A A;  3NXT A;  3NXO A;  2OBC A;  1DYI A;  3JWM A;  1QZF A;  3NRR A;  4IXE D;  3K45 A;  4DDR A;  1CD2 A;  1M7A A;  3QG2 A;  1LUD A;  4XT7 A;  1DRA A;  3CD2 A;  1S3W A;  3OCH A;  3DRC A;  3NXV A;  3FQO A;  3K74 A;  3JW5 A;  3QLS A;  3S3V A;  3UM6 A;  3FS6 A;  3FQ0 A;  3CLB A;  4QJC A;  2GD9 A;  4PTJ A;  3IA5 A;  1RF7 A;  4H96 A;  3FY8 X;  5JG0 X;  3NZB X;  3FRF X;  1DRH A;  1DR5 A;  4M6K A;  4H97 A;  1KMS A;  4QHV A;  3ZPC A;  1RA2 A;  2HM9 A;  3SQY X;  3DAT A;  3FQV A;  4P68 A;  3IX9 A;  2W9T A;  4HOG A;  3QL0 A;  4KAK A;  4QLF A;  2FZH A;  4Q6A A;  3QYL A;  4TU5 X;  2W3M A;  5DFR A;  2BLC A;  4G95 A;  3K2H A;  3I3R A;  4KFJ A;  2D0K A;  3JVX A;  4G8Z X;  3F91 A;  3OAF A;  5CCC A;  1S3Y A;  3ZPG A;  1DHJ A;  4I1N A;  4KY4 A;  3TQ8 A;  2DHF A;  5HT5 A;  4M7U A;  2W3B A;  4X5G A;  3IA4 A;  3F0X X;  3M09 A;  1DR3 A;  4IXF X;  1DHF A;  5HF2 X;  4ECK A;  4PSS A;  4FGG A;  2W9H A;  3GI2 A;  3SAI A;  1RX6 A;  3D84 X;  3CL9 A;  1DYJ A;  1PD8 A;  1RB3 A;  2AZN A;  3F0V X;  4I13 A;  4ELG A;  1HFP A;  3KGY A;  2LF1 A;  1RX7 A;  3LG4 A;  1IA4 A;  4FGH A;  2FZJ A;  1RA9 A;  1RX8 A;  1RH3 A;  5CC9 A;  3NZC X;  1M78 A;  4KD7 A;  1DR2 A;  1DLS A;  5HUI A;  1RX2 A;  1TDR A;  7DFR A;  3R33 A;  2W3W A;  4KEB A;  3QGT A;  5HPB A;  3NZ9 X;  4XT4 A;  3GHV A;  1M79 A;  2D5N A;  3JWF A;  3F0Q X;  3NXX A;  2OIP A;  1DRB A;  3DL5 A;  3JTW A;  1LY4 A;  3UM5 A;  4X5I A;  3Q1H A;  1AI9 A;  3CSE A;  3F0B X;  4EIG A;  3TQ9 A;  2P4G A;  1DR7 A;  3E0B A;  3QFX A;  3QLR A;  2W9G A;  2CIG A;  3FY9 X;  5HF0 X;  1JOM A;  3F8Y A;  4HA7 A;  1SEJ A;  3EEJ A;  3JW3 A;  3EEK A;  4NX7 A;  3NTZ A;  4ELE A;  3SRS X;  1PDB A;  3INV A;  5HVB A;  4OR7 A;  1BOZ A;  2B3Z A;  5U27 A;  3ROA A;  3TD8 A;  3D80 A;  4ELH A;  3SRU X;  5U26 A;  3NZD A;  1MVS A;  1DDR A;  4PTH A;  4HOE A;  4IXG X;  1DYH A;  3VCO A;  1AO8 A;  3DGA A;  2HQP A;  3SRR X;  3QL3 A;  4KJK A;  1DHI A;  5HT4 A;  3IRM A;  1RA8 A;  1RX5 A;  4KY8 A;  3NZ6 X;  2KGK A; 
#chains in the Genus database with same CATH topology
 3NXR A;  2XW7 A;  1IA1 A;  4FHB A;  1YHO A;  2W9S A;  1J3K A;  3L3R A;  3RO9 A;  1AOE A;  1J3I A;  4EIZ A;  1RE7 A;  4Q0E A;  4KM0 A;  5FDA A;  2QK8 A;  4X5H A;  3SH2 A;  3KY8 A;  4PST A;  1IA3 A;  4PDJ A;  2C2S A;  2JYB A;  1RA1 A;  4Q0D A;  4ELB A;  3QLY A;  3DG8 A;  3DFR A;  4P66 A;  4EIL A;  3QLZ A;  2G6V A;  2O7P A;  1J3J A;  3M08 A;  5EAJ A;  4CD2 A;  4KJL A;  5ECC A;  4XT5 A;  3SRQ X;  1KLK A;  1DG7 A;  3F0S X;  3SA1 A;  4QLG A;  4P3R A;  1RX4 A;  4KL9 A;  3KFY A;  3EEM A;  1HFR A;  4LAE X;  3KJS A;  4DFR A;  3NU0 A;  5HI6 A;  4H98 A;  1RX3 A;  2FZI A;  1CZ3 A;  3EIG A;  3RG9 A;  3FYV X;  4QJZ D;  3NZA X;  4XT8 A;  1JUV A;  4DP3 A;  4P3Q A;  4X5J A;  4LAG X;  3HJ3 A;  1E26 A;  3DL6 A;  1U70 A;  1OHJ A;  1DG5 A;  3JSU A;  4M7V A;  4ELF A;  1LY3 A;  3FQZ A;  5DXV A;  4XEC X;  3KJR A;  3TQA A;  4DPD A;  4KYA A;  1DF7 A;  4Q67 A;  3TQB A;  1MVT A;  1U71 A;  1S3V A;  4X5F A;  3JWK A;  2W3A A;  2ITH A;  1DIU A;  3SRW X;  3N0H A;  5HQZ A;  4QI9 A;  1S3U A;  5HQY A;  1BZF A;  1OHK A;  1RA3 A;  1JOL A;  1VJ3 A;  1DDS A;  3I8A X;  2L28 A;  4KLX A;  3IRN A;  6DFR A;  4PSY A;  1DR6 A;  5HSR A;  4DPH A;  2ZZA A;  1ZDR A;  2INQ A;  1IA2 A;  2ANQ A;  3SR5 X;  4EJ1 A;  3NXY A;  4KBN A;  1HFQ A;  2BLB A;  4G3M A;  4M6J A;  3FL8 A;  3FL9 A;  2DRC A;  1DRE A;  4M6L A;  3FRB X;  3FRE X;  1U72 A;  3K47 A;  1PD9 A;  3FQF A;  1DRF A;  3QLX A;  4NX6 A;  3GHW A;  5JA3 A;  1RD7 A;  5E8Q A;  4QLE A;  2CD2 A;  4XE6 X;  4H95 A;  8DFR A;  3GYF A;  3SA2 A;  5HVE A;  2HXV A;  1RB2 A;  3IRO A;  1DLR A;  5ECX A;  3FYW X;  3UM8 A;  4LAH X;  2ANO A;  4HA9 A;  4KNE A;  1VDR A;  3SGY A;  3FRA X;  4XT6 A;  3QYO A;  1RX9 A;  3JWC A;  4RGC A;  1D1G A;  1RX1 A;  2H2Q A;  3EX8 A;  1DR1 A;  3HBB A;  3DAU A;  1DR4 A;  4OSG A;  3QLW A;  1DAJ A;  1RG7 A;  2BL9 A;  3F0U X;  4XRB A;  3F8Z A;  1DIS A;  3S9U A;  4M2X A;  4GH8 A;  4KM2 A;  3EEL A;  2W3V A;  4KJJ A;  1DYR A;  2C2T A;  2BLA A;  3GHC A;  1RC4 A;  1DG8 A;  1KMV A;  4LEK X;  5HSU A;  4HOF A;  3FQC A;  3FRD X;  3S7A A;  3NXT A;  3NXO A;  2OBC A;  1DYI A;  3JWM A;  1QZF A;  3NRR A;  4IXE D;  3K45 A;  4DDR A;  1CD2 A;  1M7A A;  3QG2 A;  1LUD A;  4XT7 A;  1DRA A;  3CD2 A;  1S3W A;  3OCH A;  3DRC A;  3NXV A;  3FQO A;  3K74 A;  3JW5 A;  3QLS A;  3S3V A;  3UM6 A;  3FS6 A;  3FQ0 A;  3CLB A;  4QJC A;  2GD9 A;  4PTJ A;  3IA5 A;  1RF7 A;  4H96 A;  3FY8 X;  5JG0 X;  3NZB X;  3FRF X;  1DRH A;  1DR5 A;  4M6K A;  4H97 A;  1KMS A;  4QHV A;  3ZPC A;  1RA2 A;  2HM9 A;  3SQY X;  3DAT A;  3FQV A;  4P68 A;  3IX9 A;  2W9T A;  4HOG A;  3QL0 A;  4KAK A;  4QLF A;  2FZH A;  4Q6A A;  3QYL A;  4TU5 X;  2W3M A;  5DFR A;  2BLC A;  4G95 A;  3K2H A;  3I3R A;  4KFJ A;  2D0K A;  3JVX A;  4G8Z X;  3F91 A;  3OAF A;  5CCC A;  1S3Y A;  3ZPG A;  1DHJ A;  4I1N A;  4KY4 A;  3TQ8 A;  2DHF A;  5HT5 A;  4M7U A;  2W3B A;  4X5G A;  3IA4 A;  3F0X X;  3M09 A;  1DR3 A;  4IXF X;  1DHF A;  5HF2 X;  4ECK A;  4PSS A;  4FGG A;  2W9H A;  3GI2 A;  3SAI A;  1RX6 A;  3D84 X;  3CL9 A;  1DYJ A;  1PD8 A;  1RB3 A;  2AZN A;  3F0V X;  4I13 A;  4ELG A;  1HFP A;  3KGY A;  2LF1 A;  1RX7 A;  3LG4 A;  1IA4 A;  4FGH A;  2FZJ A;  1RA9 A;  1RX8 A;  1RH3 A;  5CC9 A;  3NZC X;  1M78 A;  4KD7 A;  1DR2 A;  1DLS A;  5HUI A;  1RX2 A;  1TDR A;  7DFR A;  3R33 A;  2W3W A;  4KEB A;  3QGT A;  5HPB A;  3NZ9 X;  4XT4 A;  3GHV A;  1M79 A;  2D5N A;  3JWF A;  3F0Q X;  3NXX A;  2OIP A;  1DRB A;  3DL5 A;  3JTW A;  1LY4 A;  3UM5 A;  4X5I A;  3Q1H A;  1AI9 A;  3CSE A;  3F0B X;  4EIG A;  3TQ9 A;  2P4G A;  1DR7 A;  3E0B A;  3QFX A;  3QLR A;  2W9G A;  2CIG A;  3FY9 X;  5HF0 X;  1JOM A;  3F8Y A;  4HA7 A;  1SEJ A;  3EEJ A;  3JW3 A;  3EEK A;  4NX7 A;  3NTZ A;  4ELE A;  3SRS X;  1PDB A;  3INV A;  5HVB A;  4OR7 A;  1BOZ A;  2B3Z A;  5U27 A;  3ROA A;  3TD8 A;  3D80 A;  4ELH A;  3SRU X;  5U26 A;  3NZD A;  1MVS A;  1DDR A;  4PTH A;  4HOE A;  4IXG X;  1DYH A;  3VCO A;  1AO8 A;  3DGA A;  2HQP A;  3SRR X;  3QL3 A;  4KJK A;  1DHI A;  5HT4 A;  3IRM A;  1RA8 A;  1RX5 A;  4KY8 A;  3NZ6 X;  2KGK A; 
#chains in the Genus database with same CATH homology
 3NXR A;  2XW7 A;  1IA1 A;  4FHB A;  1YHO A;  2W9S A;  1J3K A;  3L3R A;  3RO9 A;  1AOE A;  1J3I A;  4EIZ A;  1RE7 A;  4Q0E A;  4KM0 A;  5FDA A;  2QK8 A;  4X5H A;  3SH2 A;  3KY8 A;  4PST A;  1IA3 A;  4PDJ A;  2C2S A;  2JYB A;  1RA1 A;  4Q0D A;  4ELB A;  3QLY A;  3DG8 A;  3DFR A;  4P66 A;  4EIL A;  3QLZ A;  2G6V A;  2O7P A;  1J3J A;  3M08 A;  5EAJ A;  4CD2 A;  4KJL A;  5ECC A;  4XT5 A;  3SRQ X;  1KLK A;  1DG7 A;  3F0S X;  3SA1 A;  4QLG A;  4P3R A;  1RX4 A;  4KL9 A;  3KFY A;  3EEM A;  1HFR A;  4LAE X;  3KJS A;  4DFR A;  3NU0 A;  5HI6 A;  4H98 A;  1RX3 A;  2FZI A;  1CZ3 A;  3EIG A;  3RG9 A;  3FYV X;  4QJZ D;  3NZA X;  4XT8 A;  1JUV A;  4DP3 A;  4P3Q A;  4X5J A;  4LAG X;  3HJ3 A;  1E26 A;  3DL6 A;  1U70 A;  1OHJ A;  1DG5 A;  3JSU A;  4M7V A;  4ELF A;  1LY3 A;  3FQZ A;  5DXV A;  4XEC X;  3KJR A;  3TQA A;  4DPD A;  4KYA A;  1DF7 A;  4Q67 A;  3TQB A;  1MVT A;  1U71 A;  1S3V A;  4X5F A;  3JWK A;  2W3A A;  2ITH A;  1DIU A;  3SRW X;  3N0H A;  5HQZ A;  4QI9 A;  1S3U A;  5HQY A;  1BZF A;  1OHK A;  1RA3 A;  1JOL A;  1VJ3 A;  1DDS A;  3I8A X;  2L28 A;  4KLX A;  3IRN A;  6DFR A;  4PSY A;  1DR6 A;  5HSR A;  4DPH A;  2ZZA A;  1ZDR A;  2INQ A;  1IA2 A;  2ANQ A;  3SR5 X;  4EJ1 A;  3NXY A;  4KBN A;  1HFQ A;  2BLB A;  4G3M A;  4M6J A;  3FL8 A;  3FL9 A;  2DRC A;  1DRE A;  4M6L A;  3FRB X;  3FRE X;  1U72 A;  3K47 A;  1PD9 A;  3FQF A;  1DRF A;  3QLX A;  4NX6 A;  3GHW A;  5JA3 A;  1RD7 A;  5E8Q A;  4QLE A;  2CD2 A;  4XE6 X;  4H95 A;  8DFR A;  3GYF A;  3SA2 A;  5HVE A;  2HXV A;  1RB2 A;  3IRO A;  1DLR A;  5ECX A;  3FYW X;  3UM8 A;  4LAH X;  2ANO A;  4HA9 A;  4KNE A;  1VDR A;  3SGY A;  3FRA X;  4XT6 A;  3QYO A;  1RX9 A;  3JWC A;  4RGC A;  1D1G A;  1RX1 A;  2H2Q A;  3EX8 A;  1DR1 A;  3HBB A;  3DAU A;  1DR4 A;  4OSG A;  3QLW A;  1DAJ A;  1RG7 A;  2BL9 A;  3F0U X;  4XRB A;  3F8Z A;  1DIS A;  3S9U A;  4M2X A;  4GH8 A;  4KM2 A;  3EEL A;  2W3V A;  4KJJ A;  1DYR A;  2C2T A;  2BLA A;  3GHC A;  1RC4 A;  1DG8 A;  1KMV A;  4LEK X;  5HSU A;  4HOF A;  3FQC A;  3FRD X;  3S7A A;  3NXT A;  3NXO A;  2OBC A;  1DYI A;  3JWM A;  1QZF A;  3NRR A;  4IXE D;  3K45 A;  4DDR A;  1CD2 A;  1M7A A;  3QG2 A;  1LUD A;  4XT7 A;  1DRA A;  3CD2 A;  1S3W A;  3OCH A;  3DRC A;  3NXV A;  3FQO A;  3K74 A;  3JW5 A;  3QLS A;  3S3V A;  3UM6 A;  3FS6 A;  3FQ0 A;  3CLB A;  4QJC A;  2GD9 A;  4PTJ A;  3IA5 A;  1RF7 A;  4H96 A;  3FY8 X;  5JG0 X;  3NZB X;  3FRF X;  1DRH A;  1DR5 A;  4M6K A;  4H97 A;  1KMS A;  4QHV A;  3ZPC A;  1RA2 A;  2HM9 A;  3SQY X;  3DAT A;  3FQV A;  4P68 A;  3IX9 A;  2W9T A;  4HOG A;  3QL0 A;  4KAK A;  4QLF A;  2FZH A;  4Q6A A;  3QYL A;  4TU5 X;  2W3M A;  5DFR A;  2BLC A;  4G95 A;  3K2H A;  3I3R A;  4KFJ A;  2D0K A;  3JVX A;  4G8Z X;  3F91 A;  3OAF A;  5CCC A;  1S3Y A;  3ZPG A;  1DHJ A;  4I1N A;  4KY4 A;  3TQ8 A;  2DHF A;  5HT5 A;  4M7U A;  2W3B A;  4X5G A;  3IA4 A;  3F0X X;  3M09 A;  1DR3 A;  4IXF X;  1DHF A;  5HF2 X;  4ECK A;  4PSS A;  4FGG A;  2W9H A;  3GI2 A;  3SAI A;  1RX6 A;  3D84 X;  3CL9 A;  1DYJ A;  1PD8 A;  1RB3 A;  2AZN A;  3F0V X;  4I13 A;  4ELG A;  1HFP A;  3KGY A;  2LF1 A;  1RX7 A;  3LG4 A;  1IA4 A;  4FGH A;  2FZJ A;  1RA9 A;  1RX8 A;  1RH3 A;  5CC9 A;  3NZC X;  1M78 A;  4KD7 A;  1DR2 A;  1DLS A;  5HUI A;  1RX2 A;  1TDR A;  7DFR A;  3R33 A;  2W3W A;  4KEB A;  3QGT A;  5HPB A;  3NZ9 X;  4XT4 A;  3GHV A;  1M79 A;  2D5N A;  3JWF A;  3F0Q X;  3NXX A;  2OIP A;  1DRB A;  3DL5 A;  3JTW A;  1LY4 A;  3UM5 A;  4X5I A;  3Q1H A;  1AI9 A;  3CSE A;  3F0B X;  4EIG A;  3TQ9 A;  2P4G A;  1DR7 A;  3E0B A;  3QFX A;  3QLR A;  2W9G A;  2CIG A;  3FY9 X;  5HF0 X;  1JOM A;  3F8Y A;  4HA7 A;  1SEJ A;  3EEJ A;  3JW3 A;  3EEK A;  4NX7 A;  3NTZ A;  4ELE A;  3SRS X;  1PDB A;  3INV A;  5HVB A;  4OR7 A;  1BOZ A;  2B3Z A;  5U27 A;  3ROA A;  3TD8 A;  3D80 A;  4ELH A;  3SRU X;  5U26 A;  3NZD A;  1MVS A;  1DDR A;  4PTH A;  4HOE A;  4IXG X;  1DYH A;  3VCO A;  1AO8 A;  3DGA A;  2HQP A;  3SRR X;  3QL3 A;  4KJK A;  1DHI A;  5HT4 A;  3IRM A;  1RA8 A;  1RX5 A;  4KY8 A;  3NZ6 X;  2KGK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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