5HVEA

5-methyl-6-(3'-trifluromethoxyphenylthio)[2,3-d]pyrimidine 2,4-diamine
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(4'-methoxyphenythio)[2,3-d]pyrrolo-7-ethyl-2,4-diamines
rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 60
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5hveA00
1KMSA 2QK8A 2JYBA 1VDRA 3QLWA 4PDJA 3F8ZA 4XE6X 4XT7A 4ELBA 1DG7A 3F0SX 4H98A 1DHJA 1DR3A 3K47A 3M09A 4M2XA 1AO8A 3QL0A 4IXED 4QJCA 3FY8X 3FL8A 1PD9A 2HQPA 4G3MA 4Q0EA 1DHFA 5HVEA 1RH3A 4LAHX 3OCHA 1U70A 3ZPGA 3QL3A 3QLXA 4X5IA 4IXFX 3F91A 2D5NA 3IA5A 4X5GA 1KLKA 3QYLA 4OR7A 4I13A 5JG0X 1BZFA 5ECXA 2B3ZA 2BLAA 4PTJA 3SH2A 3RO9A 4PSSA 1RX8A 4QI9A 2BL9A 3UM5A 3UM6A 4FHBA 2INQA 1MVTA 3UM8A 3F0XX 3IA4A 4QLGA 4LAGX 3SR5X 3I3RA 3FRAX 2L28A 2W9TA 3QFXA 3GHCA 2HXVA 1RX7A 3EEMA 3TQBA 1TDRA 1RF7A 4EILA 4RGCA 4M7UA 3CSEA 4FGHA 2FZHA 1E26A 4HOGA 4QLEA 4XT4A 4CD2A 3FL9A 3RG9A 1DR6A 4XT6A 2W9HA 3TD8A 1LY3A 2HM9A 3IRNA 4LAEX 1DR2A 1YHOA 1RG7A 4LEKX 1DDSA 2W3AA 3NXRA 1U72A 5HT5A 3KFYA 6DFRA 3NZ9X 3JVXA 3DG8A 4TU5X 4NX7A 5JA3A 5HQZA 3KJSA 2KGKA 1DAJA 3F0VX 5HF2X 3NU0A 4HA7A 1DR1A 2W3VA 1DR5A 1S3YA 4PTHA 4ELFA 1DLSA 4I1NA 3TQ9A 3JW3A 4DDRA 3N0HA 3DL6A 5U27A 3K2HA 3EELA 1OHKA 4P3RA 3EEKA 3L3RA 4GH8A 4KBNA 1J3IA 2GD9A 1DYRA 3DATA 3E0BA 3TQAA 4QLFA 2W3MA 5HI6A 4PSYA 3GYFA 4PSTA 3SA2A 3F0UX 2AZNA 4KM2A 3FRDX 5HUIA 3NTZA 3M08A 2C2TA 1DYJA 1AI9A 1CZ3A 3JWFA 3QLZA 4M6JA 4DFRA 1RX9A 4KJLA 4P3QA 1M78A 5HT4A 3NZ6X 3FYWX 4KFJA 1LUDA 2W3WA 5HQYA 4XT8A 5HVBA 2OBCA 2O7PA 3D84X 2W9SA 2ZZAA 3NZCX 4EIGA 3F8YA 3ROAA 1RA9A 2ANQA 1HFRA 3DGAA 5HSRA 3SRQX 3SRUX 3F0BX 3FQZA 3QYOA 5HSUA 2ITHA 2XW7A 3NXVA 3Q1HA 4HA9A 3INVA 4KNEA 1S3VA 4G95A 1U71A 4KD7A 2BLBA 1RD7A 1JOMA 3QGTA 4X5JA 3JSUA 4KJJA 4P68A 3SGYA 1RA2A 4Q0DA 3FRFX 3GI2A 5HF0X 5DFRA 2W9GA 1ZDRA 3FQ0A 1DG8A 1S3WA 3NZBX 1RX5A 1MVSA 8DFRA 1S3UA 3CL9A 1JOLA 4DPDA 4HOFA 2LF1A 1DR4A 4KL9A 2OIPA 3EX8A 5CC9A 4KY4A 3NXXA 3SRSX 1RX2A 1KMVA 3LG4A 3DRCA 3NXOA 3NZAX 2DHFA 3FYVX 2D0KA 1CD2A 2G6VA 1VJ3A 2C2SA 1JUVA 3QG2A 3IX9A 4Q6AA 3EIGA 4QJZD 1RA1A 1IA4A 3DAUA 1SEJA 4P66A 1AOEA 5FDAA 1IA2A 3HBBA 3KGYA 7DFRA 1DRBA 2DRCA 3KJRA 3FY9X 4M7VA 4XRBA 5ECCA 1M7AA 1RB2A 3IROA 2H2QA 1DHIA 3S3VA 4DPHA 3FQFA 4DP3A 4EJ1A 1IA3A 1J3KA 1QZFA 4ECKA 4X5FA 3FS6A 4ELHA 4M6LA 1DYHA 4OSGA 3D80A 3CLBA 1DLRA 1DIUA 3SQYX 4KM0A 5CCCA 4ELEA 3IRMA 5EAJA 2CD2A 1HFPA 3OAFA 4KEBA 4X5HA 1IA1A 3QLRA 4KAKA 1DRAA 4KY8A 3JW5A 1DRFA 3NRRA 3QLSA 1RA8A 4HOEA 4M6KA 4H95A 3TQ8A 3FQOA 3JWMA 3FREX 3HJ3A 1M79A 3CD2A 1RA3A 3ZPCA 3GHVA 2W3BA 3GHWA 2ANOA 3SAIA 2FZJA 3NXTA 1DR7A 1RX3A 4Q67A 1RX4A 1RC4A 3SA1A 1HFQA 4EIZA 1DG5A 3JWCA 3NZDA 3K45A 3DFRA 1DREA 5E8QA 1RE7A 3KY8A 4XT5A 1PD8A 3DL5A 3VCOA 1J3JA 3FRBX 1RB3A 4H96A 2CIGA 3SRRX 1DYIA 1D1GA 5U26A 1LY4A 3F0QX 3SRWX 4QHVA 5DXVA 1RX6A 3R33A 3FQVA 4KJKA 2P4GA 3S7AA 4XECX 3JWKA 3NXYA 5HPBA 4ELGA 2BLCA 3K74A 1DDRA 4G8ZX 1OHJA 1DF7A 3FQCA 4NX6A 4FGGA 4KYAA 3QLYA 1BOZA 1PDBA 4H97A 2FZIA 3JTWA 3S9UA 1DISA 3EEJA 4IXGX 1RX1A 3I8AX 4KLXA 1DRHA
chains in the Genus database with same CATH superfamily
1KMSA 2QK8A 2JYBA 1VDRA 3QLWA 4PDJA 3F8ZA 4XE6X 4XT7A 4ELBA 1DG7A 3F0SX 4H98A 1DHJA 1DR3A 3K47A 3M09A 4M2XA 1AO8A 3QL0A 4IXED 4QJCA 3FY8X 3FL8A 1PD9A 2HQPA 4G3MA 4Q0EA 1DHFA 5HVEA 1RH3A 4LAHX 3OCHA 1U70A 3ZPGA 3QL3A 3QLXA 4X5IA 4IXFX 3F91A 2D5NA 3IA5A 4X5GA 1KLKA 3QYLA 4OR7A 4I13A 5JG0X 1BZFA 5ECXA 2B3ZA 2BLAA 4PTJA 3SH2A 3RO9A 4PSSA 1RX8A 4QI9A 2BL9A 3UM5A 3UM6A 4FHBA 2INQA 1MVTA 3UM8A 3F0XX 3IA4A 4QLGA 4LAGX 3SR5X 3I3RA 3FRAX 2L28A 2W9TA 3QFXA 3GHCA 2HXVA 1RX7A 3EEMA 3TQBA 1TDRA 1RF7A 4EILA 4RGCA 4M7UA 3CSEA 4FGHA 2FZHA 1E26A 4HOGA 4QLEA 4XT4A 4CD2A 3FL9A 3RG9A 1DR6A 4XT6A 2W9HA 3TD8A 1LY3A 2HM9A 3IRNA 4LAEX 1DR2A 1YHOA 1RG7A 4LEKX 1DDSA 2W3AA 3NXRA 1U72A 5HT5A 3KFYA 6DFRA 3NZ9X 3JVXA 3DG8A 4TU5X 4NX7A 5JA3A 5HQZA 3KJSA 2KGKA 1DAJA 3F0VX 5HF2X 3NU0A 4HA7A 1DR1A 2W3VA 1DR5A 1S3YA 4PTHA 4ELFA 1DLSA 4I1NA 3TQ9A 3JW3A 4DDRA 3N0HA 3DL6A 5U27A 3K2HA 3EELA 1OHKA 4P3RA 3EEKA 3L3RA 4GH8A 4KBNA 1J3IA 2GD9A 1DYRA 3DATA 3E0BA 3TQAA 4QLFA 2W3MA 5HI6A 4PSYA 3GYFA 4PSTA 3SA2A 3F0UX 2AZNA 4KM2A 3FRDX 5HUIA 3NTZA 3M08A 2C2TA 1DYJA 1AI9A 1CZ3A 3JWFA 3QLZA 4M6JA 4DFRA 1RX9A 4KJLA 4P3QA 1M78A 5HT4A 3NZ6X 3FYWX 4KFJA 1LUDA 2W3WA 5HQYA 4XT8A 5HVBA 2OBCA 2O7PA 3D84X 2W9SA 2ZZAA 3NZCX 4EIGA 3F8YA 3ROAA 1RA9A 2ANQA 1HFRA 3DGAA 5HSRA 3SRQX 3SRUX 3F0BX 3FQZA 3QYOA 5HSUA 2ITHA 2XW7A 3NXVA 3Q1HA 4HA9A 3INVA 4KNEA 1S3VA 4G95A 1U71A 4KD7A 2BLBA 1RD7A 1JOMA 3QGTA 4X5JA 3JSUA 4KJJA 4P68A 3SGYA 1RA2A 4Q0DA 3FRFX 3GI2A 5HF0X 5DFRA 2W9GA 1ZDRA 3FQ0A 1DG8A 1S3WA 3NZBX 1RX5A 1MVSA 8DFRA 1S3UA 3CL9A 1JOLA 4DPDA 4HOFA 2LF1A 1DR4A 4KL9A 2OIPA 3EX8A 5CC9A 4KY4A 3NXXA 3SRSX 1RX2A 1KMVA 3LG4A 3DRCA 3NXOA 3NZAX 2DHFA 3FYVX 2D0KA 1CD2A 2G6VA 1VJ3A 2C2SA 1JUVA 3QG2A 3IX9A 4Q6AA 3EIGA 4QJZD 1RA1A 1IA4A 3DAUA 1SEJA 4P66A 1AOEA 5FDAA 1IA2A 3HBBA 3KGYA 7DFRA 1DRBA 2DRCA 3KJRA 3FY9X 4M7VA 4XRBA 5ECCA 1M7AA 1RB2A 3IROA 2H2QA 1DHIA 3S3VA 4DPHA 3FQFA 4DP3A 4EJ1A 1IA3A 1J3KA 1QZFA 4ECKA 4X5FA 3FS6A 4ELHA 4M6LA 1DYHA 4OSGA 3D80A 3CLBA 1DLRA 1DIUA 3SQYX 4KM0A 5CCCA 4ELEA 3IRMA 5EAJA 2CD2A 1HFPA 3OAFA 4KEBA 4X5HA 1IA1A 3QLRA 4KAKA 1DRAA 4KY8A 3JW5A 1DRFA 3NRRA 3QLSA 1RA8A 4HOEA 4M6KA 4H95A 3TQ8A 3FQOA 3JWMA 3FREX 3HJ3A 1M79A 3CD2A 1RA3A 3ZPCA 3GHVA 2W3BA 3GHWA 2ANOA 3SAIA 2FZJA 3NXTA 1DR7A 1RX3A 4Q67A 1RX4A 1RC4A 3SA1A 1HFQA 4EIZA 1DG5A 3JWCA 3NZDA 3K45A 3DFRA 1DREA 5E8QA 1RE7A 3KY8A 4XT5A 1PD8A 3DL5A 3VCOA 1J3JA 3FRBX 1RB3A 4H96A 2CIGA 3SRRX 1DYIA 1D1GA 5U26A 1LY4A 3F0QX 3SRWX 4QHVA 5DXVA 1RX6A 3R33A 3FQVA 4KJKA 2P4GA 3S7AA 4XECX 3JWKA 3NXYA 5HPBA 4ELGA 2BLCA 3K74A 1DDRA 4G8ZX 1OHJA 1DF7A 3FQCA 4NX6A 4FGGA 4KYAA 3QLYA 1BOZA 1PDBA 4H97A 2FZIA 3JTWA 3S9UA 1DISA 3EEJA 4IXGX 1RX1A 3I8AX 4KLXA 1DRHA
chains in the Genus database with same CATH topology
1KMSA 2QK8A 2JYBA 1VDRA 3QLWA 4PDJA 3F8ZA 4XE6X 4XT7A 4ELBA 1DG7A 3F0SX 4H98A 1DHJA 1DR3A 3K47A 3M09A 4M2XA 1AO8A 3QL0A 4IXED 4QJCA 3FY8X 3FL8A 1PD9A 2HQPA 4G3MA 4Q0EA 1DHFA 5HVEA 1RH3A 4LAHX 3OCHA 1U70A 3ZPGA 3QL3A 3QLXA 4X5IA 4IXFX 3F91A 2D5NA 3IA5A 4X5GA 1KLKA 3QYLA 4OR7A 4I13A 5JG0X 1BZFA 5ECXA 2B3ZA 2BLAA 4PTJA 3SH2A 3RO9A 4PSSA 1RX8A 4QI9A 2BL9A 3UM5A 3UM6A 4FHBA 2INQA 1MVTA 3UM8A 3F0XX 3IA4A 4QLGA 4LAGX 3SR5X 3I3RA 3FRAX 2L28A 2W9TA 3QFXA 3GHCA 2HXVA 1RX7A 3EEMA 3TQBA 1TDRA 1RF7A 4EILA 4RGCA 4M7UA 3CSEA 4FGHA 2FZHA 1E26A 4HOGA 4QLEA 4XT4A 4CD2A 3FL9A 3RG9A 1DR6A 4XT6A 2W9HA 3TD8A 1LY3A 2HM9A 3IRNA 4LAEX 1DR2A 1YHOA 1RG7A 4LEKX 1DDSA 2W3AA 3NXRA 1U72A 5HT5A 3KFYA 6DFRA 3NZ9X 3JVXA 3DG8A 4TU5X 4NX7A 5JA3A 5HQZA 3KJSA 2KGKA 1DAJA 3F0VX 5HF2X 3NU0A 4HA7A 1DR1A 2W3VA 1DR5A 1S3YA 4PTHA 4ELFA 1DLSA 4I1NA 3TQ9A 3JW3A 4DDRA 3N0HA 3DL6A 5U27A 3K2HA 3EELA 1OHKA 4P3RA 3EEKA 3L3RA 4GH8A 4KBNA 1J3IA 2GD9A 1DYRA 3DATA 3E0BA 3TQAA 4QLFA 2W3MA 5HI6A 4PSYA 3GYFA 4PSTA 3SA2A 3F0UX 2AZNA 4KM2A 3FRDX 5HUIA 3NTZA 3M08A 2C2TA 1DYJA 1AI9A 1CZ3A 3JWFA 3QLZA 4M6JA 4DFRA 1RX9A 4KJLA 4P3QA 1M78A 5HT4A 3NZ6X 3FYWX 4KFJA 1LUDA 2W3WA 5HQYA 4XT8A 5HVBA 2OBCA 2O7PA 3D84X 2W9SA 2ZZAA 3NZCX 4EIGA 3F8YA 3ROAA 1RA9A 2ANQA 1HFRA 3DGAA 5HSRA 3SRQX 3SRUX 3F0BX 3FQZA 3QYOA 5HSUA 2ITHA 2XW7A 3NXVA 3Q1HA 4HA9A 3INVA 4KNEA 1S3VA 4G95A 1U71A 4KD7A 2BLBA 1RD7A 1JOMA 3QGTA 4X5JA 3JSUA 4KJJA 4P68A 3SGYA 1RA2A 4Q0DA 3FRFX 3GI2A 5HF0X 5DFRA 2W9GA 1ZDRA 3FQ0A 1DG8A 1S3WA 3NZBX 1RX5A 1MVSA 8DFRA 1S3UA 3CL9A 1JOLA 4DPDA 4HOFA 2LF1A 1DR4A 4KL9A 2OIPA 3EX8A 5CC9A 4KY4A 3NXXA 3SRSX 1RX2A 1KMVA 3LG4A 3DRCA 3NXOA 3NZAX 2DHFA 3FYVX 2D0KA 1CD2A 2G6VA 1VJ3A 2C2SA 1JUVA 3QG2A 3IX9A 4Q6AA 3EIGA 4QJZD 1RA1A 1IA4A 3DAUA 1SEJA 4P66A 1AOEA 5FDAA 1IA2A 3HBBA 3KGYA 7DFRA 1DRBA 2DRCA 3KJRA 3FY9X 4M7VA 4XRBA 5ECCA 1M7AA 1RB2A 3IROA 2H2QA 1DHIA 3S3VA 4DPHA 3FQFA 4DP3A 4EJ1A 1IA3A 1J3KA 1QZFA 4ECKA 4X5FA 3FS6A 4ELHA 4M6LA 1DYHA 4OSGA 3D80A 3CLBA 1DLRA 1DIUA 3SQYX 4KM0A 5CCCA 4ELEA 3IRMA 5EAJA 2CD2A 1HFPA 3OAFA 4KEBA 4X5HA 1IA1A 3QLRA 4KAKA 1DRAA 4KY8A 3JW5A 1DRFA 3NRRA 3QLSA 1RA8A 4HOEA 4M6KA 4H95A 3TQ8A 3FQOA 3JWMA 3FREX 3HJ3A 1M79A 3CD2A 1RA3A 3ZPCA 3GHVA 2W3BA 3GHWA 2ANOA 3SAIA 2FZJA 3NXTA 1DR7A 1RX3A 4Q67A 1RX4A 1RC4A 3SA1A 1HFQA 4EIZA 1DG5A 3JWCA 3NZDA 3K45A 3DFRA 1DREA 5E8QA 1RE7A 3KY8A 4XT5A 1PD8A 3DL5A 3VCOA 1J3JA 3FRBX 1RB3A 4H96A 2CIGA 3SRRX 1DYIA 1D1GA 5U26A 1LY4A 3F0QX 3SRWX 4QHVA 5DXVA 1RX6A 3R33A 3FQVA 4KJKA 2P4GA 3S7AA 4XECX 3JWKA 3NXYA 5HPBA 4ELGA 2BLCA 3K74A 1DDRA 4G8ZX 1OHJA 1DF7A 3FQCA 4NX6A 4FGGA 4KYAA 3QLYA 1BOZA 1PDBA 4H97A 2FZIA 3JTWA 3S9UA 1DISA 3EEJA 4IXGX 1RX1A 3I8AX 4KLXA 1DRHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KMS A;  2QK8 A;  2JYB A;  1VDR A;  3QLW A;  4PDJ A;  3F8Z A;  4XE6 X;  4XT7 A;  4ELB A;  1DG7 A;  3F0S X;  4H98 A;  1DHJ A;  1DR3 A;  3K47 A;  3M09 A;  4M2X A;  1AO8 A;  3QL0 A;  4IXE D;  4QJC A;  3FY8 X;  3FL8 A;  1PD9 A;  2HQP A;  4G3M A;  4Q0E A;  1DHF A;  5HVE A;  1RH3 A;  4LAH X;  3OCH A;  1U70 A;  3ZPG A;  3QL3 A;  3QLX A;  4X5I A;  4IXF X;  3F91 A;  2D5N A;  3IA5 A;  4X5G A;  1KLK A;  3QYL A;  4OR7 A;  4I13 A;  5JG0 X;  1BZF A;  5ECX A;  2B3Z A;  2BLA A;  4PTJ A;  3SH2 A;  3RO9 A;  4PSS A;  1RX8 A;  4QI9 A;  2BL9 A;  3UM5 A;  3UM6 A;  4FHB A;  2INQ A;  1MVT A;  3UM8 A;  3F0X X;  3IA4 A;  4QLG A;  4LAG X;  3SR5 X;  3I3R A;  3FRA X;  2L28 A;  2W9T A;  3QFX A;  3GHC A;  2HXV A;  1RX7 A;  3EEM A;  3TQB A;  1TDR A;  1RF7 A;  4EIL A;  4RGC A;  4M7U A;  3CSE A;  4FGH A;  2FZH A;  1E26 A;  4HOG A;  4QLE A;  4XT4 A;  4CD2 A;  3FL9 A;  3RG9 A;  1DR6 A;  4XT6 A;  2W9H A;  3TD8 A;  1LY3 A;  2HM9 A;  3IRN A;  4LAE X;  1DR2 A;  1YHO A;  1RG7 A;  4LEK X;  1DDS A;  2W3A A;  3NXR A;  1U72 A;  5HT5 A;  3KFY A;  6DFR A;  3NZ9 X;  3JVX A;  3DG8 A;  4TU5 X;  4NX7 A;  5JA3 A;  5HQZ A;  3KJS A;  2KGK A;  1DAJ A;  3F0V X;  5HF2 X;  3NU0 A;  4HA7 A;  1DR1 A;  2W3V A;  1DR5 A;  1S3Y A;  4PTH A;  4ELF A;  1DLS A;  4I1N A;  3TQ9 A;  3JW3 A;  4DDR A;  3N0H A;  3DL6 A;  5U27 A;  3K2H A;  3EEL A;  1OHK A;  4P3R A;  3EEK A;  3L3R A;  4GH8 A;  4KBN A;  1J3I A;  2GD9 A;  1DYR A;  3DAT A;  3E0B A;  3TQA A;  4QLF A;  2W3M A;  5HI6 A;  4PSY A;  3GYF A;  4PST A;  3SA2 A;  3F0U X;  2AZN A;  4KM2 A;  3FRD X;  5HUI A;  3NTZ A;  3M08 A;  2C2T A;  1DYJ A;  1AI9 A;  1CZ3 A;  3JWF A;  3QLZ A;  4M6J A;  4DFR A;  1RX9 A;  4KJL A;  4P3Q A;  1M78 A;  5HT4 A;  3NZ6 X;  3FYW X;  4KFJ A;  1LUD A;  2W3W A;  5HQY A;  4XT8 A;  5HVB A;  2OBC A;  2O7P A;  3D84 X;  2W9S A;  2ZZA A;  3NZC X;  4EIG A;  3F8Y A;  3ROA A;  1RA9 A;  2ANQ A;  1HFR A;  3DGA A;  5HSR A;  3SRQ X;  3SRU X;  3F0B X;  3FQZ A;  3QYO A;  5HSU A;  2ITH A;  2XW7 A;  3NXV A;  3Q1H A;  4HA9 A;  3INV A;  4KNE A;  1S3V A;  4G95 A;  1U71 A;  4KD7 A;  2BLB A;  1RD7 A;  1JOM A;  3QGT A;  4X5J A;  3JSU A;  4KJJ A;  4P68 A;  3SGY A;  1RA2 A;  4Q0D A;  3FRF X;  3GI2 A;  5HF0 X;  5DFR A;  2W9G A;  1ZDR A;  3FQ0 A;  1DG8 A;  1S3W A;  3NZB X;  1RX5 A;  1MVS A;  8DFR A;  1S3U A;  3CL9 A;  1JOL A;  4DPD A;  4HOF A;  2LF1 A;  1DR4 A;  4KL9 A;  2OIP A;  3EX8 A;  5CC9 A;  4KY4 A;  3NXX A;  3SRS X;  1RX2 A;  1KMV A;  3LG4 A;  3DRC A;  3NXO A;  3NZA X;  2DHF A;  3FYV X;  2D0K A;  1CD2 A;  2G6V A;  1VJ3 A;  2C2S A;  1JUV A;  3QG2 A;  3IX9 A;  4Q6A A;  3EIG A;  4QJZ D;  1RA1 A;  1IA4 A;  3DAU A;  1SEJ A;  4P66 A;  1AOE A;  5FDA A;  1IA2 A;  3HBB A;  3KGY A;  7DFR A;  1DRB A;  2DRC A;  3KJR A;  3FY9 X;  4M7V A;  4XRB A;  5ECC A;  1M7A A;  1RB2 A;  3IRO A;  2H2Q A;  1DHI A;  3S3V A;  4DPH A;  3FQF A;  4DP3 A;  4EJ1 A;  1IA3 A;  1J3K A;  1QZF A;  4ECK A;  4X5F A;  3FS6 A;  4ELH A;  4M6L A;  1DYH A;  4OSG A;  3D80 A;  3CLB A;  1DLR A;  1DIU A;  3SQY X;  4KM0 A;  5CCC A;  4ELE A;  3IRM A;  5EAJ A;  2CD2 A;  1HFP A;  3OAF A;  4KEB A;  4X5H A;  1IA1 A;  3QLR A;  4KAK A;  1DRA A;  4KY8 A;  3JW5 A;  1DRF A;  3NRR A;  3QLS A;  1RA8 A;  4HOE A;  4M6K A;  4H95 A;  3TQ8 A;  3FQO A;  3JWM A;  3FRE X;  3HJ3 A;  1M79 A;  3CD2 A;  1RA3 A;  3ZPC A;  3GHV A;  2W3B A;  3GHW A;  2ANO A;  3SAI A;  2FZJ A;  3NXT A;  1DR7 A;  1RX3 A;  4Q67 A;  1RX4 A;  1RC4 A;  3SA1 A;  1HFQ A;  4EIZ A;  1DG5 A;  3JWC A;  3NZD A;  3K45 A;  3DFR A;  1DRE A;  5E8Q A;  1RE7 A;  3KY8 A;  4XT5 A;  1PD8 A;  3DL5 A;  3VCO A;  1J3J A;  3FRB X;  1RB3 A;  4H96 A;  2CIG A;  3SRR X;  1DYI A;  1D1G A;  5U26 A;  1LY4 A;  3F0Q X;  3SRW X;  4QHV A;  5DXV A;  1RX6 A;  3R33 A;  3FQV A;  4KJK A;  2P4G A;  3S7A A;  4XEC X;  3JWK A;  3NXY A;  5HPB A;  4ELG A;  2BLC A;  3K74 A;  1DDR A;  4G8Z X;  1OHJ A;  1DF7 A;  3FQC A;  4NX6 A;  4FGG A;  4KYA A;  3QLY A;  1BOZ A;  1PDB A;  4H97 A;  2FZI A;  3JTW A;  3S9U A;  1DIS A;  3EEJ A;  4IXG X;  1RX1 A;  3I8A X;  4KLX A;  1DRH A; 
#chains in the Genus database with same CATH topology
 1KMS A;  2QK8 A;  2JYB A;  1VDR A;  3QLW A;  4PDJ A;  3F8Z A;  4XE6 X;  4XT7 A;  4ELB A;  1DG7 A;  3F0S X;  4H98 A;  1DHJ A;  1DR3 A;  3K47 A;  3M09 A;  4M2X A;  1AO8 A;  3QL0 A;  4IXE D;  4QJC A;  3FY8 X;  3FL8 A;  1PD9 A;  2HQP A;  4G3M A;  4Q0E A;  1DHF A;  5HVE A;  1RH3 A;  4LAH X;  3OCH A;  1U70 A;  3ZPG A;  3QL3 A;  3QLX A;  4X5I A;  4IXF X;  3F91 A;  2D5N A;  3IA5 A;  4X5G A;  1KLK A;  3QYL A;  4OR7 A;  4I13 A;  5JG0 X;  1BZF A;  5ECX A;  2B3Z A;  2BLA A;  4PTJ A;  3SH2 A;  3RO9 A;  4PSS A;  1RX8 A;  4QI9 A;  2BL9 A;  3UM5 A;  3UM6 A;  4FHB A;  2INQ A;  1MVT A;  3UM8 A;  3F0X X;  3IA4 A;  4QLG A;  4LAG X;  3SR5 X;  3I3R A;  3FRA X;  2L28 A;  2W9T A;  3QFX A;  3GHC A;  2HXV A;  1RX7 A;  3EEM A;  3TQB A;  1TDR A;  1RF7 A;  4EIL A;  4RGC A;  4M7U A;  3CSE A;  4FGH A;  2FZH A;  1E26 A;  4HOG A;  4QLE A;  4XT4 A;  4CD2 A;  3FL9 A;  3RG9 A;  1DR6 A;  4XT6 A;  2W9H A;  3TD8 A;  1LY3 A;  2HM9 A;  3IRN A;  4LAE X;  1DR2 A;  1YHO A;  1RG7 A;  4LEK X;  1DDS A;  2W3A A;  3NXR A;  1U72 A;  5HT5 A;  3KFY A;  6DFR A;  3NZ9 X;  3JVX A;  3DG8 A;  4TU5 X;  4NX7 A;  5JA3 A;  5HQZ A;  3KJS A;  2KGK A;  1DAJ A;  3F0V X;  5HF2 X;  3NU0 A;  4HA7 A;  1DR1 A;  2W3V A;  1DR5 A;  1S3Y A;  4PTH A;  4ELF A;  1DLS A;  4I1N A;  3TQ9 A;  3JW3 A;  4DDR A;  3N0H A;  3DL6 A;  5U27 A;  3K2H A;  3EEL A;  1OHK A;  4P3R A;  3EEK A;  3L3R A;  4GH8 A;  4KBN A;  1J3I A;  2GD9 A;  1DYR A;  3DAT A;  3E0B A;  3TQA A;  4QLF A;  2W3M A;  5HI6 A;  4PSY A;  3GYF A;  4PST A;  3SA2 A;  3F0U X;  2AZN A;  4KM2 A;  3FRD X;  5HUI A;  3NTZ A;  3M08 A;  2C2T A;  1DYJ A;  1AI9 A;  1CZ3 A;  3JWF A;  3QLZ A;  4M6J A;  4DFR A;  1RX9 A;  4KJL A;  4P3Q A;  1M78 A;  5HT4 A;  3NZ6 X;  3FYW X;  4KFJ A;  1LUD A;  2W3W A;  5HQY A;  4XT8 A;  5HVB A;  2OBC A;  2O7P A;  3D84 X;  2W9S A;  2ZZA A;  3NZC X;  4EIG A;  3F8Y A;  3ROA A;  1RA9 A;  2ANQ A;  1HFR A;  3DGA A;  5HSR A;  3SRQ X;  3SRU X;  3F0B X;  3FQZ A;  3QYO A;  5HSU A;  2ITH A;  2XW7 A;  3NXV A;  3Q1H A;  4HA9 A;  3INV A;  4KNE A;  1S3V A;  4G95 A;  1U71 A;  4KD7 A;  2BLB A;  1RD7 A;  1JOM A;  3QGT A;  4X5J A;  3JSU A;  4KJJ A;  4P68 A;  3SGY A;  1RA2 A;  4Q0D A;  3FRF X;  3GI2 A;  5HF0 X;  5DFR A;  2W9G A;  1ZDR A;  3FQ0 A;  1DG8 A;  1S3W A;  3NZB X;  1RX5 A;  1MVS A;  8DFR A;  1S3U A;  3CL9 A;  1JOL A;  4DPD A;  4HOF A;  2LF1 A;  1DR4 A;  4KL9 A;  2OIP A;  3EX8 A;  5CC9 A;  4KY4 A;  3NXX A;  3SRS X;  1RX2 A;  1KMV A;  3LG4 A;  3DRC A;  3NXO A;  3NZA X;  2DHF A;  3FYV X;  2D0K A;  1CD2 A;  2G6V A;  1VJ3 A;  2C2S A;  1JUV A;  3QG2 A;  3IX9 A;  4Q6A A;  3EIG A;  4QJZ D;  1RA1 A;  1IA4 A;  3DAU A;  1SEJ A;  4P66 A;  1AOE A;  5FDA A;  1IA2 A;  3HBB A;  3KGY A;  7DFR A;  1DRB A;  2DRC A;  3KJR A;  3FY9 X;  4M7V A;  4XRB A;  5ECC A;  1M7A A;  1RB2 A;  3IRO A;  2H2Q A;  1DHI A;  3S3V A;  4DPH A;  3FQF A;  4DP3 A;  4EJ1 A;  1IA3 A;  1J3K A;  1QZF A;  4ECK A;  4X5F A;  3FS6 A;  4ELH A;  4M6L A;  1DYH A;  4OSG A;  3D80 A;  3CLB A;  1DLR A;  1DIU A;  3SQY X;  4KM0 A;  5CCC A;  4ELE A;  3IRM A;  5EAJ A;  2CD2 A;  1HFP A;  3OAF A;  4KEB A;  4X5H A;  1IA1 A;  3QLR A;  4KAK A;  1DRA A;  4KY8 A;  3JW5 A;  1DRF A;  3NRR A;  3QLS A;  1RA8 A;  4HOE A;  4M6K A;  4H95 A;  3TQ8 A;  3FQO A;  3JWM A;  3FRE X;  3HJ3 A;  1M79 A;  3CD2 A;  1RA3 A;  3ZPC A;  3GHV A;  2W3B A;  3GHW A;  2ANO A;  3SAI A;  2FZJ A;  3NXT A;  1DR7 A;  1RX3 A;  4Q67 A;  1RX4 A;  1RC4 A;  3SA1 A;  1HFQ A;  4EIZ A;  1DG5 A;  3JWC A;  3NZD A;  3K45 A;  3DFR A;  1DRE A;  5E8Q A;  1RE7 A;  3KY8 A;  4XT5 A;  1PD8 A;  3DL5 A;  3VCO A;  1J3J A;  3FRB X;  1RB3 A;  4H96 A;  2CIG A;  3SRR X;  1DYI A;  1D1G A;  5U26 A;  1LY4 A;  3F0Q X;  3SRW X;  4QHV A;  5DXV A;  1RX6 A;  3R33 A;  3FQV A;  4KJK A;  2P4G A;  3S7A A;  4XEC X;  3JWK A;  3NXY A;  5HPB A;  4ELG A;  2BLC A;  3K74 A;  1DDR A;  4G8Z X;  1OHJ A;  1DF7 A;  3FQC A;  4NX6 A;  4FGG A;  4KYA A;  3QLY A;  1BOZ A;  1PDB A;  4H97 A;  2FZI A;  3JTW A;  3S9U A;  1DIS A;  3EEJ A;  4IXG X;  1RX1 A;  3I8A X;  4KLX A;  1DRH A; 
#chains in the Genus database with same CATH homology
 1KMS A;  2QK8 A;  2JYB A;  1VDR A;  3QLW A;  4PDJ A;  3F8Z A;  4XE6 X;  4XT7 A;  4ELB A;  1DG7 A;  3F0S X;  4H98 A;  1DHJ A;  1DR3 A;  3K47 A;  3M09 A;  4M2X A;  1AO8 A;  3QL0 A;  4IXE D;  4QJC A;  3FY8 X;  3FL8 A;  1PD9 A;  2HQP A;  4G3M A;  4Q0E A;  1DHF A;  5HVE A;  1RH3 A;  4LAH X;  3OCH A;  1U70 A;  3ZPG A;  3QL3 A;  3QLX A;  4X5I A;  4IXF X;  3F91 A;  2D5N A;  3IA5 A;  4X5G A;  1KLK A;  3QYL A;  4OR7 A;  4I13 A;  5JG0 X;  1BZF A;  5ECX A;  2B3Z A;  2BLA A;  4PTJ A;  3SH2 A;  3RO9 A;  4PSS A;  1RX8 A;  4QI9 A;  2BL9 A;  3UM5 A;  3UM6 A;  4FHB A;  2INQ A;  1MVT A;  3UM8 A;  3F0X X;  3IA4 A;  4QLG A;  4LAG X;  3SR5 X;  3I3R A;  3FRA X;  2L28 A;  2W9T A;  3QFX A;  3GHC A;  2HXV A;  1RX7 A;  3EEM A;  3TQB A;  1TDR A;  1RF7 A;  4EIL A;  4RGC A;  4M7U A;  3CSE A;  4FGH A;  2FZH A;  1E26 A;  4HOG A;  4QLE A;  4XT4 A;  4CD2 A;  3FL9 A;  3RG9 A;  1DR6 A;  4XT6 A;  2W9H A;  3TD8 A;  1LY3 A;  2HM9 A;  3IRN A;  4LAE X;  1DR2 A;  1YHO A;  1RG7 A;  4LEK X;  1DDS A;  2W3A A;  3NXR A;  1U72 A;  5HT5 A;  3KFY A;  6DFR A;  3NZ9 X;  3JVX A;  3DG8 A;  4TU5 X;  4NX7 A;  5JA3 A;  5HQZ A;  3KJS A;  2KGK A;  1DAJ A;  3F0V X;  5HF2 X;  3NU0 A;  4HA7 A;  1DR1 A;  2W3V A;  1DR5 A;  1S3Y A;  4PTH A;  4ELF A;  1DLS A;  4I1N A;  3TQ9 A;  3JW3 A;  4DDR A;  3N0H A;  3DL6 A;  5U27 A;  3K2H A;  3EEL A;  1OHK A;  4P3R A;  3EEK A;  3L3R A;  4GH8 A;  4KBN A;  1J3I A;  2GD9 A;  1DYR A;  3DAT A;  3E0B A;  3TQA A;  4QLF A;  2W3M A;  5HI6 A;  4PSY A;  3GYF A;  4PST A;  3SA2 A;  3F0U X;  2AZN A;  4KM2 A;  3FRD X;  5HUI A;  3NTZ A;  3M08 A;  2C2T A;  1DYJ A;  1AI9 A;  1CZ3 A;  3JWF A;  3QLZ A;  4M6J A;  4DFR A;  1RX9 A;  4KJL A;  4P3Q A;  1M78 A;  5HT4 A;  3NZ6 X;  3FYW X;  4KFJ A;  1LUD A;  2W3W A;  5HQY A;  4XT8 A;  5HVB A;  2OBC A;  2O7P A;  3D84 X;  2W9S A;  2ZZA A;  3NZC X;  4EIG A;  3F8Y A;  3ROA A;  1RA9 A;  2ANQ A;  1HFR A;  3DGA A;  5HSR A;  3SRQ X;  3SRU X;  3F0B X;  3FQZ A;  3QYO A;  5HSU A;  2ITH A;  2XW7 A;  3NXV A;  3Q1H A;  4HA9 A;  3INV A;  4KNE A;  1S3V A;  4G95 A;  1U71 A;  4KD7 A;  2BLB A;  1RD7 A;  1JOM A;  3QGT A;  4X5J A;  3JSU A;  4KJJ A;  4P68 A;  3SGY A;  1RA2 A;  4Q0D A;  3FRF X;  3GI2 A;  5HF0 X;  5DFR A;  2W9G A;  1ZDR A;  3FQ0 A;  1DG8 A;  1S3W A;  3NZB X;  1RX5 A;  1MVS A;  8DFR A;  1S3U A;  3CL9 A;  1JOL A;  4DPD A;  4HOF A;  2LF1 A;  1DR4 A;  4KL9 A;  2OIP A;  3EX8 A;  5CC9 A;  4KY4 A;  3NXX A;  3SRS X;  1RX2 A;  1KMV A;  3LG4 A;  3DRC A;  3NXO A;  3NZA X;  2DHF A;  3FYV X;  2D0K A;  1CD2 A;  2G6V A;  1VJ3 A;  2C2S A;  1JUV A;  3QG2 A;  3IX9 A;  4Q6A A;  3EIG A;  4QJZ D;  1RA1 A;  1IA4 A;  3DAU A;  1SEJ A;  4P66 A;  1AOE A;  5FDA A;  1IA2 A;  3HBB A;  3KGY A;  7DFR A;  1DRB A;  2DRC A;  3KJR A;  3FY9 X;  4M7V A;  4XRB A;  5ECC A;  1M7A A;  1RB2 A;  3IRO A;  2H2Q A;  1DHI A;  3S3V A;  4DPH A;  3FQF A;  4DP3 A;  4EJ1 A;  1IA3 A;  1J3K A;  1QZF A;  4ECK A;  4X5F A;  3FS6 A;  4ELH A;  4M6L A;  1DYH A;  4OSG A;  3D80 A;  3CLB A;  1DLR A;  1DIU A;  3SQY X;  4KM0 A;  5CCC A;  4ELE A;  3IRM A;  5EAJ A;  2CD2 A;  1HFP A;  3OAF A;  4KEB A;  4X5H A;  1IA1 A;  3QLR A;  4KAK A;  1DRA A;  4KY8 A;  3JW5 A;  1DRF A;  3NRR A;  3QLS A;  1RA8 A;  4HOE A;  4M6K A;  4H95 A;  3TQ8 A;  3FQO A;  3JWM A;  3FRE X;  3HJ3 A;  1M79 A;  3CD2 A;  1RA3 A;  3ZPC A;  3GHV A;  2W3B A;  3GHW A;  2ANO A;  3SAI A;  2FZJ A;  3NXT A;  1DR7 A;  1RX3 A;  4Q67 A;  1RX4 A;  1RC4 A;  3SA1 A;  1HFQ A;  4EIZ A;  1DG5 A;  3JWC A;  3NZD A;  3K45 A;  3DFR A;  1DRE A;  5E8Q A;  1RE7 A;  3KY8 A;  4XT5 A;  1PD8 A;  3DL5 A;  3VCO A;  1J3J A;  3FRB X;  1RB3 A;  4H96 A;  2CIG A;  3SRR X;  1DYI A;  1D1G A;  5U26 A;  1LY4 A;  3F0Q X;  3SRW X;  4QHV A;  5DXV A;  1RX6 A;  3R33 A;  3FQV A;  4KJK A;  2P4G A;  3S7A A;  4XEC X;  3JWK A;  3NXY A;  5HPB A;  4ELG A;  2BLC A;  3K74 A;  1DDR A;  4G8Z X;  1OHJ A;  1DF7 A;  3FQC A;  4NX6 A;  4FGG A;  4KYA A;  3QLY A;  1BOZ A;  1PDB A;  4H97 A;  2FZI A;  3JTW A;  3S9U A;  1DIS A;  3EEJ A;  4IXG X;  1RX1 A;  3I8A X;  4KLX A;  1DRH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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