5DFRA

Crystal structure of unliganded escherichia coli dihydrofolate reductase. ligand-induced conformational changes and cooperativity in binding
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
159
structure length
154
Chain Sequence
MISLIAALAVDRVIGPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 40
structure length 154
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1988-10-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5dfrA00
2W3MA 3NZAX 3F91A 5HF0X 3F0VX 3S7AA 4G3MA 1D1GA 3FL8A 3ZPGA 5HQYA 4EILA 4QI9A 1DR6A 4PSTA 2C2SA 2FZHA 4P3QA 3FRBX 3DAUA 3NXTA 1DIUA 3QL0A 5HT5A 1AO8A 3CD2A 3NRRA 5ECCA 4XT4A 1AI9A 3DL6A 3DGAA 2ANQA 3DRCA 1DYHA 1VJ3A 4XRBA 1DR4A 4QLGA 3FREX 1QZFA 3TQBA 5DFRA 3NU0A 4PSSA 3NZBX 1PDBA 1E26A 1AOEA 4KL9A 2W9GA 4I1NA 4M6JA 3RG9A 4G8ZX 3TQ9A 2FZJA 2O7PA 5U27A 8DFRA 1JOMA 2L28A 2QK8A 1DF7A 3TD8A 4Q67A 3SH2A 3GI2A 3IROA 4P66A 3SRRX 4KBNA 3HBBA 3JSUA 3R33A 3FL9A 3SA2A 3QLWA 4OR7A 3IA5A 5EAJA 3VCOA 2XW7A 4DPDA 1DG8A 3HJ3A 4H97A 4KFJA 4KYAA 3SRSX 3M09A 3QLXA 4KD7A 4CD2A 3NXOA 1LUDA 3NXXA 4KM2A 1JOLA 4DFRA 1RX4A 1BZFA 3DATA 5HQZA 3IA4A 4XT7A 1RD7A 1DHJA 3JTWA 3M08A 4X5HA 1DDSA 3D84X 6DFRA 1DREA 4QLFA 1RF7A 5HT4A 5JA3A 3QG2A 1DYRA 3QGTA 3JWMA 1DR2A 4X5FA 3UM5A 1S3YA 3QYLA 2B3ZA 4X5GA 1RH3A 3EEMA 1RA9A 1J3KA 3SAIA 2BLBA 1CD2A 1RG7A 4G95A 3GHWA 4RGCA 3FYWX 4P68A 4HA9A 3JWFA 4XT6A 3F0UX 3K2HA 1SEJA 1M78A 3INVA 2G6VA 3SRWX 1DHFA 2W3BA 2W3VA 3F8ZA 1S3VA 3NZDA 1PD9A 4Q0DA 4ECKA 4IXED 5E8QA 4DP3A 1J3IA 4NX7A 5HSUA 1DG5A 2ANOA 4XECX 1DRHA 3QYOA 1TDRA 3FQZA 1RX1A 4FGHA 1DG7A 3UM8A 2HQPA 4KJJA 3FY8X 3FQOA 1DHIA 4KAKA 1IA2A 4KJLA 2W9SA 3FQCA 3NZCX 1IA4A 2ITHA 3FYVX 2GD9A 1RC4A 3EIGA 3L3RA 4KY4A 3F0QX 3KFYA 3JWCA 2W3AA 3IRMA 4XT5A 5HI6A 3SRQX 2C2TA 3F0XX 1DLRA 5JG0X 4GH8A 2AZNA 2W9TA 3NTZA 2CIGA 1M7AA 3DL5A 5HSRA 4XE6X 1KLKA 1DR7A 3F0SX 1OHJA 3CSEA 5DXVA 2HXVA 3S3VA 4M7UA 4KNEA 2H2QA 2ZZAA 1LY4A 4IXGX 2HM9A 3QFXA 7DFRA 4KM0A 3JVXA 3Q1HA 1DRAA 3F0BX 1J3JA 3NZ6X 3JW3A 3S9UA 2KGKA 5HVEA 3QLRA 1IA3A 5ECXA 1CZ3A 4LAHX 1RX8A 4ELGA 3N0HA 4HOGA 2BLCA 3JW5A 1KMSA 2OBCA 3EEKA 3KGYA 3FY9X 4HOEA 4H96A 4KLXA 4OSGA 3QLSA 3EEJA 2OIPA 4IXFX 4LAEX 4M2XA 4QJZD 1DDRA 1U72A 1RA8A 4ELEA 1RX2A 1RX3A 4LAGX 1DR1A 1VDRA 2CD2A 1LY3A 2FZIA 3RO9A 3K74A 3KJSA 3SRUX 1DAJA 1RX6A 4EIGA 3JWKA 2D5NA 1PD8A 1RE7A 2P4GA 2DRCA 5CCCA 3FQVA 4HOFA 2DHFA 1U71A 3I3RA 3F8YA 3GHCA 2BL9A 5HUIA 5U26A 2BLAA 3E0BA 4LEKX 4PSYA 1MVSA 3TQ8A 3UM6A 4M6LA 5FDAA 4KEBA 4M6KA 3SGYA 3SR5X 1RB3A 1RX7A 1S3UA 4ELBA 3FRDX 3SA1A 4QJCA 3ROAA 4TU5X 1RB2A 4QLEA 4HA7A 3CL9A 5HVBA 1HFQA 4P3RA 1BOZA 4X5JA 1S3WA 5HPBA 3SQYX 3D80A 1MVTA 3OCHA 4PTHA 1DYJA 3FRAX 3KJRA 3TQAA 3FRFX 4EJ1A 3NXYA 1DLSA 3K47A 3EX8A 4Q6AA 3IX9A 3QLZA 1ZDRA 3NXVA 1DYIA 4M7VA 1RA2A 3EELA 1DRFA 3DFRA 1YHOA 2W9HA 3OAFA 3NXRA 3NZ9X 4H95A 4EIZA 1DISA 1IA1A 3FQFA 3FS6A 1KMVA 4QHVA 3I8AX 1DR3A 4KJKA 2INQA 3KY8A 3IRNA 3LG4A 2W3WA 3K45A 4Q0EA 1RX9A 4ELFA 4FGGA 4PDJA 1DRBA 1HFPA 1JUVA 4FHBA 3GHVA 4NX6A 1DR5A 4PTJA 4XT8A 1RA1A 3GYFA 1RX5A 3CLBA 2JYBA 3QL3A 3DG8A 4KY8A 3FQ0A 4DPHA 4I13A 1OHKA 1U70A 5HF2X 2D0KA 1M79A 2LF1A 3ZPCA 4H98A 5CC9A 3QLYA 4DDRA 4ELHA 1HFRA 1RA3A 4X5IA
chains in the Genus database with same CATH superfamily
2W3MA 3NZAX 3F91A 5HF0X 3F0VX 3S7AA 4G3MA 1D1GA 3FL8A 3ZPGA 5HQYA 4EILA 4QI9A 1DR6A 4PSTA 2C2SA 2FZHA 4P3QA 3FRBX 3DAUA 3NXTA 1DIUA 3QL0A 5HT5A 1AO8A 3CD2A 3NRRA 5ECCA 4XT4A 1AI9A 3DL6A 3DGAA 2ANQA 3DRCA 1DYHA 1VJ3A 4XRBA 1DR4A 4QLGA 3FREX 1QZFA 3TQBA 5DFRA 3NU0A 4PSSA 3NZBX 1PDBA 1E26A 1AOEA 4KL9A 2W9GA 4I1NA 4M6JA 3RG9A 4G8ZX 3TQ9A 2FZJA 2O7PA 5U27A 8DFRA 1JOMA 2L28A 2QK8A 1DF7A 3TD8A 4Q67A 3SH2A 3GI2A 3IROA 4P66A 3SRRX 4KBNA 3HBBA 3JSUA 3R33A 3FL9A 3SA2A 3QLWA 4OR7A 3IA5A 5EAJA 3VCOA 2XW7A 4DPDA 1DG8A 3HJ3A 4H97A 4KFJA 4KYAA 3SRSX 3M09A 3QLXA 4KD7A 4CD2A 3NXOA 1LUDA 3NXXA 4KM2A 1JOLA 4DFRA 1RX4A 1BZFA 3DATA 5HQZA 3IA4A 4XT7A 1RD7A 1DHJA 3JTWA 3M08A 4X5HA 1DDSA 3D84X 6DFRA 1DREA 4QLFA 1RF7A 5HT4A 5JA3A 3QG2A 1DYRA 3QGTA 3JWMA 1DR2A 4X5FA 3UM5A 1S3YA 3QYLA 2B3ZA 4X5GA 1RH3A 3EEMA 1RA9A 1J3KA 3SAIA 2BLBA 1CD2A 1RG7A 4G95A 3GHWA 4RGCA 3FYWX 4P68A 4HA9A 3JWFA 4XT6A 3F0UX 3K2HA 1SEJA 1M78A 3INVA 2G6VA 3SRWX 1DHFA 2W3BA 2W3VA 3F8ZA 1S3VA 3NZDA 1PD9A 4Q0DA 4ECKA 4IXED 5E8QA 4DP3A 1J3IA 4NX7A 5HSUA 1DG5A 2ANOA 4XECX 1DRHA 3QYOA 1TDRA 3FQZA 1RX1A 4FGHA 1DG7A 3UM8A 2HQPA 4KJJA 3FY8X 3FQOA 1DHIA 4KAKA 1IA2A 4KJLA 2W9SA 3FQCA 3NZCX 1IA4A 2ITHA 3FYVX 2GD9A 1RC4A 3EIGA 3L3RA 4KY4A 3F0QX 3KFYA 3JWCA 2W3AA 3IRMA 4XT5A 5HI6A 3SRQX 2C2TA 3F0XX 1DLRA 5JG0X 4GH8A 2AZNA 2W9TA 3NTZA 2CIGA 1M7AA 3DL5A 5HSRA 4XE6X 1KLKA 1DR7A 3F0SX 1OHJA 3CSEA 5DXVA 2HXVA 3S3VA 4M7UA 4KNEA 2H2QA 2ZZAA 1LY4A 4IXGX 2HM9A 3QFXA 7DFRA 4KM0A 3JVXA 3Q1HA 1DRAA 3F0BX 1J3JA 3NZ6X 3JW3A 3S9UA 2KGKA 5HVEA 3QLRA 1IA3A 5ECXA 1CZ3A 4LAHX 1RX8A 4ELGA 3N0HA 4HOGA 2BLCA 3JW5A 1KMSA 2OBCA 3EEKA 3KGYA 3FY9X 4HOEA 4H96A 4KLXA 4OSGA 3QLSA 3EEJA 2OIPA 4IXFX 4LAEX 4M2XA 4QJZD 1DDRA 1U72A 1RA8A 4ELEA 1RX2A 1RX3A 4LAGX 1DR1A 1VDRA 2CD2A 1LY3A 2FZIA 3RO9A 3K74A 3KJSA 3SRUX 1DAJA 1RX6A 4EIGA 3JWKA 2D5NA 1PD8A 1RE7A 2P4GA 2DRCA 5CCCA 3FQVA 4HOFA 2DHFA 1U71A 3I3RA 3F8YA 3GHCA 2BL9A 5HUIA 5U26A 2BLAA 3E0BA 4LEKX 4PSYA 1MVSA 3TQ8A 3UM6A 4M6LA 5FDAA 4KEBA 4M6KA 3SGYA 3SR5X 1RB3A 1RX7A 1S3UA 4ELBA 3FRDX 3SA1A 4QJCA 3ROAA 4TU5X 1RB2A 4QLEA 4HA7A 3CL9A 5HVBA 1HFQA 4P3RA 1BOZA 4X5JA 1S3WA 5HPBA 3SQYX 3D80A 1MVTA 3OCHA 4PTHA 1DYJA 3FRAX 3KJRA 3TQAA 3FRFX 4EJ1A 3NXYA 1DLSA 3K47A 3EX8A 4Q6AA 3IX9A 3QLZA 1ZDRA 3NXVA 1DYIA 4M7VA 1RA2A 3EELA 1DRFA 3DFRA 1YHOA 2W9HA 3OAFA 3NXRA 3NZ9X 4H95A 4EIZA 1DISA 1IA1A 3FQFA 3FS6A 1KMVA 4QHVA 3I8AX 1DR3A 4KJKA 2INQA 3KY8A 3IRNA 3LG4A 2W3WA 3K45A 4Q0EA 1RX9A 4ELFA 4FGGA 4PDJA 1DRBA 1HFPA 1JUVA 4FHBA 3GHVA 4NX6A 1DR5A 4PTJA 4XT8A 1RA1A 3GYFA 1RX5A 3CLBA 2JYBA 3QL3A 3DG8A 4KY8A 3FQ0A 4DPHA 4I13A 1OHKA 1U70A 5HF2X 2D0KA 1M79A 2LF1A 3ZPCA 4H98A 5CC9A 3QLYA 4DDRA 4ELHA 1HFRA 1RA3A 4X5IA
chains in the Genus database with same CATH topology
2W3MA 3NZAX 3F91A 5HF0X 3F0VX 3S7AA 4G3MA 1D1GA 3FL8A 3ZPGA 5HQYA 4EILA 4QI9A 1DR6A 4PSTA 2C2SA 2FZHA 4P3QA 3FRBX 3DAUA 3NXTA 1DIUA 3QL0A 5HT5A 1AO8A 3CD2A 3NRRA 5ECCA 4XT4A 1AI9A 3DL6A 3DGAA 2ANQA 3DRCA 1DYHA 1VJ3A 4XRBA 1DR4A 4QLGA 3FREX 1QZFA 3TQBA 5DFRA 3NU0A 4PSSA 3NZBX 1PDBA 1E26A 1AOEA 4KL9A 2W9GA 4I1NA 4M6JA 3RG9A 4G8ZX 3TQ9A 2FZJA 2O7PA 5U27A 8DFRA 1JOMA 2L28A 2QK8A 1DF7A 3TD8A 4Q67A 3SH2A 3GI2A 3IROA 4P66A 3SRRX 4KBNA 3HBBA 3JSUA 3R33A 3FL9A 3SA2A 3QLWA 4OR7A 3IA5A 5EAJA 3VCOA 2XW7A 4DPDA 1DG8A 3HJ3A 4H97A 4KFJA 4KYAA 3SRSX 3M09A 3QLXA 4KD7A 4CD2A 3NXOA 1LUDA 3NXXA 4KM2A 1JOLA 4DFRA 1RX4A 1BZFA 3DATA 5HQZA 3IA4A 4XT7A 1RD7A 1DHJA 3JTWA 3M08A 4X5HA 1DDSA 3D84X 6DFRA 1DREA 4QLFA 1RF7A 5HT4A 5JA3A 3QG2A 1DYRA 3QGTA 3JWMA 1DR2A 4X5FA 3UM5A 1S3YA 3QYLA 2B3ZA 4X5GA 1RH3A 3EEMA 1RA9A 1J3KA 3SAIA 2BLBA 1CD2A 1RG7A 4G95A 3GHWA 4RGCA 3FYWX 4P68A 4HA9A 3JWFA 4XT6A 3F0UX 3K2HA 1SEJA 1M78A 3INVA 2G6VA 3SRWX 1DHFA 2W3BA 2W3VA 3F8ZA 1S3VA 3NZDA 1PD9A 4Q0DA 4ECKA 4IXED 5E8QA 4DP3A 1J3IA 4NX7A 5HSUA 1DG5A 2ANOA 4XECX 1DRHA 3QYOA 1TDRA 3FQZA 1RX1A 4FGHA 1DG7A 3UM8A 2HQPA 4KJJA 3FY8X 3FQOA 1DHIA 4KAKA 1IA2A 4KJLA 2W9SA 3FQCA 3NZCX 1IA4A 2ITHA 3FYVX 2GD9A 1RC4A 3EIGA 3L3RA 4KY4A 3F0QX 3KFYA 3JWCA 2W3AA 3IRMA 4XT5A 5HI6A 3SRQX 2C2TA 3F0XX 1DLRA 5JG0X 4GH8A 2AZNA 2W9TA 3NTZA 2CIGA 1M7AA 3DL5A 5HSRA 4XE6X 1KLKA 1DR7A 3F0SX 1OHJA 3CSEA 5DXVA 2HXVA 3S3VA 4M7UA 4KNEA 2H2QA 2ZZAA 1LY4A 4IXGX 2HM9A 3QFXA 7DFRA 4KM0A 3JVXA 3Q1HA 1DRAA 3F0BX 1J3JA 3NZ6X 3JW3A 3S9UA 2KGKA 5HVEA 3QLRA 1IA3A 5ECXA 1CZ3A 4LAHX 1RX8A 4ELGA 3N0HA 4HOGA 2BLCA 3JW5A 1KMSA 2OBCA 3EEKA 3KGYA 3FY9X 4HOEA 4H96A 4KLXA 4OSGA 3QLSA 3EEJA 2OIPA 4IXFX 4LAEX 4M2XA 4QJZD 1DDRA 1U72A 1RA8A 4ELEA 1RX2A 1RX3A 4LAGX 1DR1A 1VDRA 2CD2A 1LY3A 2FZIA 3RO9A 3K74A 3KJSA 3SRUX 1DAJA 1RX6A 4EIGA 3JWKA 2D5NA 1PD8A 1RE7A 2P4GA 2DRCA 5CCCA 3FQVA 4HOFA 2DHFA 1U71A 3I3RA 3F8YA 3GHCA 2BL9A 5HUIA 5U26A 2BLAA 3E0BA 4LEKX 4PSYA 1MVSA 3TQ8A 3UM6A 4M6LA 5FDAA 4KEBA 4M6KA 3SGYA 3SR5X 1RB3A 1RX7A 1S3UA 4ELBA 3FRDX 3SA1A 4QJCA 3ROAA 4TU5X 1RB2A 4QLEA 4HA7A 3CL9A 5HVBA 1HFQA 4P3RA 1BOZA 4X5JA 1S3WA 5HPBA 3SQYX 3D80A 1MVTA 3OCHA 4PTHA 1DYJA 3FRAX 3KJRA 3TQAA 3FRFX 4EJ1A 3NXYA 1DLSA 3K47A 3EX8A 4Q6AA 3IX9A 3QLZA 1ZDRA 3NXVA 1DYIA 4M7VA 1RA2A 3EELA 1DRFA 3DFRA 1YHOA 2W9HA 3OAFA 3NXRA 3NZ9X 4H95A 4EIZA 1DISA 1IA1A 3FQFA 3FS6A 1KMVA 4QHVA 3I8AX 1DR3A 4KJKA 2INQA 3KY8A 3IRNA 3LG4A 2W3WA 3K45A 4Q0EA 1RX9A 4ELFA 4FGGA 4PDJA 1DRBA 1HFPA 1JUVA 4FHBA 3GHVA 4NX6A 1DR5A 4PTJA 4XT8A 1RA1A 3GYFA 1RX5A 3CLBA 2JYBA 3QL3A 3DG8A 4KY8A 3FQ0A 4DPHA 4I13A 1OHKA 1U70A 5HF2X 2D0KA 1M79A 2LF1A 3ZPCA 4H98A 5CC9A 3QLYA 4DDRA 4ELHA 1HFRA 1RA3A 4X5IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W3M A;  3NZA X;  3F91 A;  5HF0 X;  3F0V X;  3S7A A;  4G3M A;  1D1G A;  3FL8 A;  3ZPG A;  5HQY A;  4EIL A;  4QI9 A;  1DR6 A;  4PST A;  2C2S A;  2FZH A;  4P3Q A;  3FRB X;  3DAU A;  3NXT A;  1DIU A;  3QL0 A;  5HT5 A;  1AO8 A;  3CD2 A;  3NRR A;  5ECC A;  4XT4 A;  1AI9 A;  3DL6 A;  3DGA A;  2ANQ A;  3DRC A;  1DYH A;  1VJ3 A;  4XRB A;  1DR4 A;  4QLG A;  3FRE X;  1QZF A;  3TQB A;  5DFR A;  3NU0 A;  4PSS A;  3NZB X;  1PDB A;  1E26 A;  1AOE A;  4KL9 A;  2W9G A;  4I1N A;  4M6J A;  3RG9 A;  4G8Z X;  3TQ9 A;  2FZJ A;  2O7P A;  5U27 A;  8DFR A;  1JOM A;  2L28 A;  2QK8 A;  1DF7 A;  3TD8 A;  4Q67 A;  3SH2 A;  3GI2 A;  3IRO A;  4P66 A;  3SRR X;  4KBN A;  3HBB A;  3JSU A;  3R33 A;  3FL9 A;  3SA2 A;  3QLW A;  4OR7 A;  3IA5 A;  5EAJ A;  3VCO A;  2XW7 A;  4DPD A;  1DG8 A;  3HJ3 A;  4H97 A;  4KFJ A;  4KYA A;  3SRS X;  3M09 A;  3QLX A;  4KD7 A;  4CD2 A;  3NXO A;  1LUD A;  3NXX A;  4KM2 A;  1JOL A;  4DFR A;  1RX4 A;  1BZF A;  3DAT A;  5HQZ A;  3IA4 A;  4XT7 A;  1RD7 A;  1DHJ A;  3JTW A;  3M08 A;  4X5H A;  1DDS A;  3D84 X;  6DFR A;  1DRE A;  4QLF A;  1RF7 A;  5HT4 A;  5JA3 A;  3QG2 A;  1DYR A;  3QGT A;  3JWM A;  1DR2 A;  4X5F A;  3UM5 A;  1S3Y A;  3QYL A;  2B3Z A;  4X5G A;  1RH3 A;  3EEM A;  1RA9 A;  1J3K A;  3SAI A;  2BLB A;  1CD2 A;  1RG7 A;  4G95 A;  3GHW A;  4RGC A;  3FYW X;  4P68 A;  4HA9 A;  3JWF A;  4XT6 A;  3F0U X;  3K2H A;  1SEJ A;  1M78 A;  3INV A;  2G6V A;  3SRW X;  1DHF A;  2W3B A;  2W3V A;  3F8Z A;  1S3V A;  3NZD A;  1PD9 A;  4Q0D A;  4ECK A;  4IXE D;  5E8Q A;  4DP3 A;  1J3I A;  4NX7 A;  5HSU A;  1DG5 A;  2ANO A;  4XEC X;  1DRH A;  3QYO A;  1TDR A;  3FQZ A;  1RX1 A;  4FGH A;  1DG7 A;  3UM8 A;  2HQP A;  4KJJ A;  3FY8 X;  3FQO A;  1DHI A;  4KAK A;  1IA2 A;  4KJL A;  2W9S A;  3FQC A;  3NZC X;  1IA4 A;  2ITH A;  3FYV X;  2GD9 A;  1RC4 A;  3EIG A;  3L3R A;  4KY4 A;  3F0Q X;  3KFY A;  3JWC A;  2W3A A;  3IRM A;  4XT5 A;  5HI6 A;  3SRQ X;  2C2T A;  3F0X X;  1DLR A;  5JG0 X;  4GH8 A;  2AZN A;  2W9T A;  3NTZ A;  2CIG A;  1M7A A;  3DL5 A;  5HSR A;  4XE6 X;  1KLK A;  1DR7 A;  3F0S X;  1OHJ A;  3CSE A;  5DXV A;  2HXV A;  3S3V A;  4M7U A;  4KNE A;  2H2Q A;  2ZZA A;  1LY4 A;  4IXG X;  2HM9 A;  3QFX A;  7DFR A;  4KM0 A;  3JVX A;  3Q1H A;  1DRA A;  3F0B X;  1J3J A;  3NZ6 X;  3JW3 A;  3S9U A;  2KGK A;  5HVE A;  3QLR A;  1IA3 A;  5ECX A;  1CZ3 A;  4LAH X;  1RX8 A;  4ELG A;  3N0H A;  4HOG A;  2BLC A;  3JW5 A;  1KMS A;  2OBC A;  3EEK A;  3KGY A;  3FY9 X;  4HOE A;  4H96 A;  4KLX A;  4OSG A;  3QLS A;  3EEJ A;  2OIP A;  4IXF X;  4LAE X;  4M2X A;  4QJZ D;  1DDR A;  1U72 A;  1RA8 A;  4ELE A;  1RX2 A;  1RX3 A;  4LAG X;  1DR1 A;  1VDR A;  2CD2 A;  1LY3 A;  2FZI A;  3RO9 A;  3K74 A;  3KJS A;  3SRU X;  1DAJ A;  1RX6 A;  4EIG A;  3JWK A;  2D5N A;  1PD8 A;  1RE7 A;  2P4G A;  2DRC A;  5CCC A;  3FQV A;  4HOF A;  2DHF A;  1U71 A;  3I3R A;  3F8Y A;  3GHC A;  2BL9 A;  5HUI A;  5U26 A;  2BLA A;  3E0B A;  4LEK X;  4PSY A;  1MVS A;  3TQ8 A;  3UM6 A;  4M6L A;  5FDA A;  4KEB A;  4M6K A;  3SGY A;  3SR5 X;  1RB3 A;  1RX7 A;  1S3U A;  4ELB A;  3FRD X;  3SA1 A;  4QJC A;  3ROA A;  4TU5 X;  1RB2 A;  4QLE A;  4HA7 A;  3CL9 A;  5HVB A;  1HFQ A;  4P3R A;  1BOZ A;  4X5J A;  1S3W A;  5HPB A;  3SQY X;  3D80 A;  1MVT A;  3OCH A;  4PTH A;  1DYJ A;  3FRA X;  3KJR A;  3TQA A;  3FRF X;  4EJ1 A;  3NXY A;  1DLS A;  3K47 A;  3EX8 A;  4Q6A A;  3IX9 A;  3QLZ A;  1ZDR A;  3NXV A;  1DYI A;  4M7V A;  1RA2 A;  3EEL A;  1DRF A;  3DFR A;  1YHO A;  2W9H A;  3OAF A;  3NXR A;  3NZ9 X;  4H95 A;  4EIZ A;  1DIS A;  1IA1 A;  3FQF A;  3FS6 A;  1KMV A;  4QHV A;  3I8A X;  1DR3 A;  4KJK A;  2INQ A;  3KY8 A;  3IRN A;  3LG4 A;  2W3W A;  3K45 A;  4Q0E A;  1RX9 A;  4ELF A;  4FGG A;  4PDJ A;  1DRB A;  1HFP A;  1JUV A;  4FHB A;  3GHV A;  4NX6 A;  1DR5 A;  4PTJ A;  4XT8 A;  1RA1 A;  3GYF A;  1RX5 A;  3CLB A;  2JYB A;  3QL3 A;  3DG8 A;  4KY8 A;  3FQ0 A;  4DPH A;  4I13 A;  1OHK A;  1U70 A;  5HF2 X;  2D0K A;  1M79 A;  2LF1 A;  3ZPC A;  4H98 A;  5CC9 A;  3QLY A;  4DDR A;  4ELH A;  1HFR A;  1RA3 A;  4X5I A; 
#chains in the Genus database with same CATH topology
 2W3M A;  3NZA X;  3F91 A;  5HF0 X;  3F0V X;  3S7A A;  4G3M A;  1D1G A;  3FL8 A;  3ZPG A;  5HQY A;  4EIL A;  4QI9 A;  1DR6 A;  4PST A;  2C2S A;  2FZH A;  4P3Q A;  3FRB X;  3DAU A;  3NXT A;  1DIU A;  3QL0 A;  5HT5 A;  1AO8 A;  3CD2 A;  3NRR A;  5ECC A;  4XT4 A;  1AI9 A;  3DL6 A;  3DGA A;  2ANQ A;  3DRC A;  1DYH A;  1VJ3 A;  4XRB A;  1DR4 A;  4QLG A;  3FRE X;  1QZF A;  3TQB A;  5DFR A;  3NU0 A;  4PSS A;  3NZB X;  1PDB A;  1E26 A;  1AOE A;  4KL9 A;  2W9G A;  4I1N A;  4M6J A;  3RG9 A;  4G8Z X;  3TQ9 A;  2FZJ A;  2O7P A;  5U27 A;  8DFR A;  1JOM A;  2L28 A;  2QK8 A;  1DF7 A;  3TD8 A;  4Q67 A;  3SH2 A;  3GI2 A;  3IRO A;  4P66 A;  3SRR X;  4KBN A;  3HBB A;  3JSU A;  3R33 A;  3FL9 A;  3SA2 A;  3QLW A;  4OR7 A;  3IA5 A;  5EAJ A;  3VCO A;  2XW7 A;  4DPD A;  1DG8 A;  3HJ3 A;  4H97 A;  4KFJ A;  4KYA A;  3SRS X;  3M09 A;  3QLX A;  4KD7 A;  4CD2 A;  3NXO A;  1LUD A;  3NXX A;  4KM2 A;  1JOL A;  4DFR A;  1RX4 A;  1BZF A;  3DAT A;  5HQZ A;  3IA4 A;  4XT7 A;  1RD7 A;  1DHJ A;  3JTW A;  3M08 A;  4X5H A;  1DDS A;  3D84 X;  6DFR A;  1DRE A;  4QLF A;  1RF7 A;  5HT4 A;  5JA3 A;  3QG2 A;  1DYR A;  3QGT A;  3JWM A;  1DR2 A;  4X5F A;  3UM5 A;  1S3Y A;  3QYL A;  2B3Z A;  4X5G A;  1RH3 A;  3EEM A;  1RA9 A;  1J3K A;  3SAI A;  2BLB A;  1CD2 A;  1RG7 A;  4G95 A;  3GHW A;  4RGC A;  3FYW X;  4P68 A;  4HA9 A;  3JWF A;  4XT6 A;  3F0U X;  3K2H A;  1SEJ A;  1M78 A;  3INV A;  2G6V A;  3SRW X;  1DHF A;  2W3B A;  2W3V A;  3F8Z A;  1S3V A;  3NZD A;  1PD9 A;  4Q0D A;  4ECK A;  4IXE D;  5E8Q A;  4DP3 A;  1J3I A;  4NX7 A;  5HSU A;  1DG5 A;  2ANO A;  4XEC X;  1DRH A;  3QYO A;  1TDR A;  3FQZ A;  1RX1 A;  4FGH A;  1DG7 A;  3UM8 A;  2HQP A;  4KJJ A;  3FY8 X;  3FQO A;  1DHI A;  4KAK A;  1IA2 A;  4KJL A;  2W9S A;  3FQC A;  3NZC X;  1IA4 A;  2ITH A;  3FYV X;  2GD9 A;  1RC4 A;  3EIG A;  3L3R A;  4KY4 A;  3F0Q X;  3KFY A;  3JWC A;  2W3A A;  3IRM A;  4XT5 A;  5HI6 A;  3SRQ X;  2C2T A;  3F0X X;  1DLR A;  5JG0 X;  4GH8 A;  2AZN A;  2W9T A;  3NTZ A;  2CIG A;  1M7A A;  3DL5 A;  5HSR A;  4XE6 X;  1KLK A;  1DR7 A;  3F0S X;  1OHJ A;  3CSE A;  5DXV A;  2HXV A;  3S3V A;  4M7U A;  4KNE A;  2H2Q A;  2ZZA A;  1LY4 A;  4IXG X;  2HM9 A;  3QFX A;  7DFR A;  4KM0 A;  3JVX A;  3Q1H A;  1DRA A;  3F0B X;  1J3J A;  3NZ6 X;  3JW3 A;  3S9U A;  2KGK A;  5HVE A;  3QLR A;  1IA3 A;  5ECX A;  1CZ3 A;  4LAH X;  1RX8 A;  4ELG A;  3N0H A;  4HOG A;  2BLC A;  3JW5 A;  1KMS A;  2OBC A;  3EEK A;  3KGY A;  3FY9 X;  4HOE A;  4H96 A;  4KLX A;  4OSG A;  3QLS A;  3EEJ A;  2OIP A;  4IXF X;  4LAE X;  4M2X A;  4QJZ D;  1DDR A;  1U72 A;  1RA8 A;  4ELE A;  1RX2 A;  1RX3 A;  4LAG X;  1DR1 A;  1VDR A;  2CD2 A;  1LY3 A;  2FZI A;  3RO9 A;  3K74 A;  3KJS A;  3SRU X;  1DAJ A;  1RX6 A;  4EIG A;  3JWK A;  2D5N A;  1PD8 A;  1RE7 A;  2P4G A;  2DRC A;  5CCC A;  3FQV A;  4HOF A;  2DHF A;  1U71 A;  3I3R A;  3F8Y A;  3GHC A;  2BL9 A;  5HUI A;  5U26 A;  2BLA A;  3E0B A;  4LEK X;  4PSY A;  1MVS A;  3TQ8 A;  3UM6 A;  4M6L A;  5FDA A;  4KEB A;  4M6K A;  3SGY A;  3SR5 X;  1RB3 A;  1RX7 A;  1S3U A;  4ELB A;  3FRD X;  3SA1 A;  4QJC A;  3ROA A;  4TU5 X;  1RB2 A;  4QLE A;  4HA7 A;  3CL9 A;  5HVB A;  1HFQ A;  4P3R A;  1BOZ A;  4X5J A;  1S3W A;  5HPB A;  3SQY X;  3D80 A;  1MVT A;  3OCH A;  4PTH A;  1DYJ A;  3FRA X;  3KJR A;  3TQA A;  3FRF X;  4EJ1 A;  3NXY A;  1DLS A;  3K47 A;  3EX8 A;  4Q6A A;  3IX9 A;  3QLZ A;  1ZDR A;  3NXV A;  1DYI A;  4M7V A;  1RA2 A;  3EEL A;  1DRF A;  3DFR A;  1YHO A;  2W9H A;  3OAF A;  3NXR A;  3NZ9 X;  4H95 A;  4EIZ A;  1DIS A;  1IA1 A;  3FQF A;  3FS6 A;  1KMV A;  4QHV A;  3I8A X;  1DR3 A;  4KJK A;  2INQ A;  3KY8 A;  3IRN A;  3LG4 A;  2W3W A;  3K45 A;  4Q0E A;  1RX9 A;  4ELF A;  4FGG A;  4PDJ A;  1DRB A;  1HFP A;  1JUV A;  4FHB A;  3GHV A;  4NX6 A;  1DR5 A;  4PTJ A;  4XT8 A;  1RA1 A;  3GYF A;  1RX5 A;  3CLB A;  2JYB A;  3QL3 A;  3DG8 A;  4KY8 A;  3FQ0 A;  4DPH A;  4I13 A;  1OHK A;  1U70 A;  5HF2 X;  2D0K A;  1M79 A;  2LF1 A;  3ZPC A;  4H98 A;  5CC9 A;  3QLY A;  4DDR A;  4ELH A;  1HFR A;  1RA3 A;  4X5I A; 
#chains in the Genus database with same CATH homology
 2W3M A;  3NZA X;  3F91 A;  5HF0 X;  3F0V X;  3S7A A;  4G3M A;  1D1G A;  3FL8 A;  3ZPG A;  5HQY A;  4EIL A;  4QI9 A;  1DR6 A;  4PST A;  2C2S A;  2FZH A;  4P3Q A;  3FRB X;  3DAU A;  3NXT A;  1DIU A;  3QL0 A;  5HT5 A;  1AO8 A;  3CD2 A;  3NRR A;  5ECC A;  4XT4 A;  1AI9 A;  3DL6 A;  3DGA A;  2ANQ A;  3DRC A;  1DYH A;  1VJ3 A;  4XRB A;  1DR4 A;  4QLG A;  3FRE X;  1QZF A;  3TQB A;  5DFR A;  3NU0 A;  4PSS A;  3NZB X;  1PDB A;  1E26 A;  1AOE A;  4KL9 A;  2W9G A;  4I1N A;  4M6J A;  3RG9 A;  4G8Z X;  3TQ9 A;  2FZJ A;  2O7P A;  5U27 A;  8DFR A;  1JOM A;  2L28 A;  2QK8 A;  1DF7 A;  3TD8 A;  4Q67 A;  3SH2 A;  3GI2 A;  3IRO A;  4P66 A;  3SRR X;  4KBN A;  3HBB A;  3JSU A;  3R33 A;  3FL9 A;  3SA2 A;  3QLW A;  4OR7 A;  3IA5 A;  5EAJ A;  3VCO A;  2XW7 A;  4DPD A;  1DG8 A;  3HJ3 A;  4H97 A;  4KFJ A;  4KYA A;  3SRS X;  3M09 A;  3QLX A;  4KD7 A;  4CD2 A;  3NXO A;  1LUD A;  3NXX A;  4KM2 A;  1JOL A;  4DFR A;  1RX4 A;  1BZF A;  3DAT A;  5HQZ A;  3IA4 A;  4XT7 A;  1RD7 A;  1DHJ A;  3JTW A;  3M08 A;  4X5H A;  1DDS A;  3D84 X;  6DFR A;  1DRE A;  4QLF A;  1RF7 A;  5HT4 A;  5JA3 A;  3QG2 A;  1DYR A;  3QGT A;  3JWM A;  1DR2 A;  4X5F A;  3UM5 A;  1S3Y A;  3QYL A;  2B3Z A;  4X5G A;  1RH3 A;  3EEM A;  1RA9 A;  1J3K A;  3SAI A;  2BLB A;  1CD2 A;  1RG7 A;  4G95 A;  3GHW A;  4RGC A;  3FYW X;  4P68 A;  4HA9 A;  3JWF A;  4XT6 A;  3F0U X;  3K2H A;  1SEJ A;  1M78 A;  3INV A;  2G6V A;  3SRW X;  1DHF A;  2W3B A;  2W3V A;  3F8Z A;  1S3V A;  3NZD A;  1PD9 A;  4Q0D A;  4ECK A;  4IXE D;  5E8Q A;  4DP3 A;  1J3I A;  4NX7 A;  5HSU A;  1DG5 A;  2ANO A;  4XEC X;  1DRH A;  3QYO A;  1TDR A;  3FQZ A;  1RX1 A;  4FGH A;  1DG7 A;  3UM8 A;  2HQP A;  4KJJ A;  3FY8 X;  3FQO A;  1DHI A;  4KAK A;  1IA2 A;  4KJL A;  2W9S A;  3FQC A;  3NZC X;  1IA4 A;  2ITH A;  3FYV X;  2GD9 A;  1RC4 A;  3EIG A;  3L3R A;  4KY4 A;  3F0Q X;  3KFY A;  3JWC A;  2W3A A;  3IRM A;  4XT5 A;  5HI6 A;  3SRQ X;  2C2T A;  3F0X X;  1DLR A;  5JG0 X;  4GH8 A;  2AZN A;  2W9T A;  3NTZ A;  2CIG A;  1M7A A;  3DL5 A;  5HSR A;  4XE6 X;  1KLK A;  1DR7 A;  3F0S X;  1OHJ A;  3CSE A;  5DXV A;  2HXV A;  3S3V A;  4M7U A;  4KNE A;  2H2Q A;  2ZZA A;  1LY4 A;  4IXG X;  2HM9 A;  3QFX A;  7DFR A;  4KM0 A;  3JVX A;  3Q1H A;  1DRA A;  3F0B X;  1J3J A;  3NZ6 X;  3JW3 A;  3S9U A;  2KGK A;  5HVE A;  3QLR A;  1IA3 A;  5ECX A;  1CZ3 A;  4LAH X;  1RX8 A;  4ELG A;  3N0H A;  4HOG A;  2BLC A;  3JW5 A;  1KMS A;  2OBC A;  3EEK A;  3KGY A;  3FY9 X;  4HOE A;  4H96 A;  4KLX A;  4OSG A;  3QLS A;  3EEJ A;  2OIP A;  4IXF X;  4LAE X;  4M2X A;  4QJZ D;  1DDR A;  1U72 A;  1RA8 A;  4ELE A;  1RX2 A;  1RX3 A;  4LAG X;  1DR1 A;  1VDR A;  2CD2 A;  1LY3 A;  2FZI A;  3RO9 A;  3K74 A;  3KJS A;  3SRU X;  1DAJ A;  1RX6 A;  4EIG A;  3JWK A;  2D5N A;  1PD8 A;  1RE7 A;  2P4G A;  2DRC A;  5CCC A;  3FQV A;  4HOF A;  2DHF A;  1U71 A;  3I3R A;  3F8Y A;  3GHC A;  2BL9 A;  5HUI A;  5U26 A;  2BLA A;  3E0B A;  4LEK X;  4PSY A;  1MVS A;  3TQ8 A;  3UM6 A;  4M6L A;  5FDA A;  4KEB A;  4M6K A;  3SGY A;  3SR5 X;  1RB3 A;  1RX7 A;  1S3U A;  4ELB A;  3FRD X;  3SA1 A;  4QJC A;  3ROA A;  4TU5 X;  1RB2 A;  4QLE A;  4HA7 A;  3CL9 A;  5HVB A;  1HFQ A;  4P3R A;  1BOZ A;  4X5J A;  1S3W A;  5HPB A;  3SQY X;  3D80 A;  1MVT A;  3OCH A;  4PTH A;  1DYJ A;  3FRA X;  3KJR A;  3TQA A;  3FRF X;  4EJ1 A;  3NXY A;  1DLS A;  3K47 A;  3EX8 A;  4Q6A A;  3IX9 A;  3QLZ A;  1ZDR A;  3NXV A;  1DYI A;  4M7V A;  1RA2 A;  3EEL A;  1DRF A;  3DFR A;  1YHO A;  2W9H A;  3OAF A;  3NXR A;  3NZ9 X;  4H95 A;  4EIZ A;  1DIS A;  1IA1 A;  3FQF A;  3FS6 A;  1KMV A;  4QHV A;  3I8A X;  1DR3 A;  4KJK A;  2INQ A;  3KY8 A;  3IRN A;  3LG4 A;  2W3W A;  3K45 A;  4Q0E A;  1RX9 A;  4ELF A;  4FGG A;  4PDJ A;  1DRB A;  1HFP A;  1JUV A;  4FHB A;  3GHV A;  4NX6 A;  1DR5 A;  4PTJ A;  4XT8 A;  1RA1 A;  3GYF A;  1RX5 A;  3CLB A;  2JYB A;  3QL3 A;  3DG8 A;  4KY8 A;  3FQ0 A;  4DPH A;  4I13 A;  1OHK A;  1U70 A;  5HF2 X;  2D0K A;  1M79 A;  2LF1 A;  3ZPC A;  4H98 A;  5CC9 A;  3QLY A;  4DDR A;  4ELH A;  1HFR A;  1RA3 A;  4X5I A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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