5HQYA

Human dihydrofolate reductase complex with nadph and 5-methyl-6-(2',3',4'-trifluorophenylthio)thieno[2,3-d]pyrimidine-2,4-diamine
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines
rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 53
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-01-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5hqyA00
1RB3A 4PSTA 4HA7A 1DHIA 4QLFA 2ZZAA 4DPDA 3FQVA 2P4GA 2QK8A 2ITHA 4I1NA 5HI6A 4Q0EA 2G6VA 3QL0A 1DG7A 4EILA 4FGGA 1E26A 1KMVA 1KLKA 1HFPA 8DFRA 4LAGX 3DFRA 3ROAA 1DAJA 1AI9A 3CD2A 5HT4A 4KM2A 3TQ9A 1DR6A 1DR5A 2FZIA 4KJJA 3F0QX 1HFRA 1DYHA 3GHCA 3HBBA 3INVA 3TQBA 3EEJA 4M2XA 1RX5A 4XT7A 1PDBA 2B3ZA 4NX6A 2ANOA 3RG9A 3IRMA 3S9UA 4IXGX 3M09A 3NZCX 2AZNA 1PD8A 4KY8A 3NTZA 3FQ0A 1DYJA 3K74A 3JW5A 5U27A 4KJKA 3TQ8A 2ANQA 1YHOA 2XW7A 4H95A 3EEMA 3NXXA 4X5FA 5HPBA 5HQZA 1DG5A 4XECX 2BL9A 3SQYX 2D5NA 2FZJA 3JVXA 3SR5X 1DYIA 4P68A 4HOEA 1DR2A 3NZ6X 1AOEA 1U72A 1IA2A 3OAFA 2BLAA 4X5HA 3SRUX 2GD9A 3QLWA 3NZAX 3JWKA 2C2SA 4TU5X 4X5JA 2H2QA 1VDRA 1LUDA 3K47A 3FL8A 3IX9A 4QHVA 4M7UA 2KGKA 1DHJA 2LF1A 4ECKA 3IROA 4IXFX 3SRRX 3CL9A 1M7AA 3QLRA 1HFQA 4CD2A 2W9GA 1RG7A 3KGYA 3E0BA 1J3JA 3UM8A 1U70A 2L28A 1DREA 3QL3A 1J3KA 4KD7A 1RD7A 1JOLA 2HQPA 4KLXA 2W3WA 4H98A 3NRRA 3SA2A 3F8ZA 4XT4A 2BLCA 3QYLA 4M6KA 3IRNA 3IA5A 3JW3A 4M6LA 3F0XX 4H96A 3D84X 3DRCA 1D1GA 1TDRA 4KM0A 2C2TA 5CCCA 4KEBA 1RE7A 1OHJA 4KFJA 3SGYA 4PTHA 3F0VX 3K45A 4DP3A 1RX6A 1S3VA 5FDAA 4HOFA 2W3VA 1DF7A 3F91A 4HA9A 4KY4A 3FRDX 1IA4A 1RX4A 4G8ZX 5EAJA 3F8YA 3JSUA 1DRBA 3DL6A 4LEKX 5CC9A 1BOZA 2INQA 4ELBA 3DATA 4QLGA 2D0KA 4Q67A 2OBCA 4EIGA 3K2HA 3NXOA 5HUIA 4M7VA 1IA3A 3OCHA 3FQCA 4M6JA 3GI2A 4P66A 3QLSA 5HVBA 1J3IA 4LAHX 3S3VA 4Q6AA 4ELHA 1DRHA 3JWMA 3N0HA 1M79A 4Q0DA 3NZDA 1RB2A 1PD9A 4OSGA 5U26A 4QI9A 3SRSX 2HM9A 3FS6A 3NU0A 1RH3A 1SEJA 3DL5A 4G3MA 1DDSA 1DR7A 3TD8A 5E8QA 1DR1A 4KL9A 4PTJA 3FY8X 3JWCA 3SH2A 1RA1A 5ECCA 4ELEA 3KJSA 4X5GA 1RA9A 3UM5A 1RX2A 1QZFA 3R33A 1KMSA 3FY9X 3RO9A 1M78A 1RC4A 3FYWX 1DHFA 3F0BX 3L3RA 4P3QA 3DAUA 2HXVA 3VCOA 3M08A 1ZDRA 3NZBX 3TQAA 3EIGA 3CLBA 3KY8A 3LG4A 5HQYA 5HSUA 3NXVA 3QLZA 3ZPGA 3FQFA 3I3RA 1S3YA 3DG8A 4PDJA 3NXRA 3QLYA 3NXYA 4XT8A 3EX8A 2W3MA 1DLSA 1LY3A 4PSSA 1RX1A 1DR3A 1VJ3A 6DFRA 1RA3A 3QLXA 4GH8A 4G95A 5DFRA 1DISA 1BZFA 3GHWA 3HJ3A 4I13A 4KNEA 3FL9A 3KJRA 4KAKA 3Q1HA 3GYFA 2W9SA 5HSRA 1JUVA 1RX3A 3I8AX 2O7PA 1JOMA 5JA3A 4FGHA 3IA4A 4DFRA 1DRFA 4QJZD 4PSYA 3SRQX 1RF7A 1RX8A 3JWFA 2FZHA 1MVTA 3D80A 1CZ3A 7DFRA 2JYBA 1IA1A 2BLBA 4LAEX 1DDRA 3QG2A 4RGCA 4DPHA 3FQOA 2W3BA 3GHVA 3NXTA 4OR7A 4P3RA 5HVEA 1DLRA 2CIGA 4EJ1A 2DRCA 3UM6A 5JG0X 3FRAX 3F0SX 4QJCA 3F0UX 3CSEA 4H97A 4IXED 1DR4A 1CD2A 3SA1A 4NX7A 5HF0X 1RX9A 3EEKA 4XE6X 1DYRA 2W9HA 3SAIA 4KBNA 4FHBA 1U71A 2W3AA 3FRBX 5DXVA 3QGTA 1DG8A 1RX7A 1S3UA 4XT5A 4KYAA 3JTWA 4XT6A 3QFXA 3ZPCA 1OHKA 4X5IA 4KJLA 1AO8A 4EIZA 1S3WA 2CD2A 4QLEA 1LY4A 5HF2X 5ECXA 1DRAA 3DGAA 2W9TA 4HOGA 4ELGA 3FRFX 3SRWX 4XRBA 3NZ9X 3KFYA 2OIPA 3FQZA 2DHFA 1RA8A 4DDRA 1DIUA 5HT5A 4ELFA 3EELA 3FREX 1RA2A 3S7AA 3FYVX 3QYOA 1MVSA
chains in the Genus database with same CATH superfamily
1RB3A 4PSTA 4HA7A 1DHIA 4QLFA 2ZZAA 4DPDA 3FQVA 2P4GA 2QK8A 2ITHA 4I1NA 5HI6A 4Q0EA 2G6VA 3QL0A 1DG7A 4EILA 4FGGA 1E26A 1KMVA 1KLKA 1HFPA 8DFRA 4LAGX 3DFRA 3ROAA 1DAJA 1AI9A 3CD2A 5HT4A 4KM2A 3TQ9A 1DR6A 1DR5A 2FZIA 4KJJA 3F0QX 1HFRA 1DYHA 3GHCA 3HBBA 3INVA 3TQBA 3EEJA 4M2XA 1RX5A 4XT7A 1PDBA 2B3ZA 4NX6A 2ANOA 3RG9A 3IRMA 3S9UA 4IXGX 3M09A 3NZCX 2AZNA 1PD8A 4KY8A 3NTZA 3FQ0A 1DYJA 3K74A 3JW5A 5U27A 4KJKA 3TQ8A 2ANQA 1YHOA 2XW7A 4H95A 3EEMA 3NXXA 4X5FA 5HPBA 5HQZA 1DG5A 4XECX 2BL9A 3SQYX 2D5NA 2FZJA 3JVXA 3SR5X 1DYIA 4P68A 4HOEA 1DR2A 3NZ6X 1AOEA 1U72A 1IA2A 3OAFA 2BLAA 4X5HA 3SRUX 2GD9A 3QLWA 3NZAX 3JWKA 2C2SA 4TU5X 4X5JA 2H2QA 1VDRA 1LUDA 3K47A 3FL8A 3IX9A 4QHVA 4M7UA 2KGKA 1DHJA 2LF1A 4ECKA 3IROA 4IXFX 3SRRX 3CL9A 1M7AA 3QLRA 1HFQA 4CD2A 2W9GA 1RG7A 3KGYA 3E0BA 1J3JA 3UM8A 1U70A 2L28A 1DREA 3QL3A 1J3KA 4KD7A 1RD7A 1JOLA 2HQPA 4KLXA 2W3WA 4H98A 3NRRA 3SA2A 3F8ZA 4XT4A 2BLCA 3QYLA 4M6KA 3IRNA 3IA5A 3JW3A 4M6LA 3F0XX 4H96A 3D84X 3DRCA 1D1GA 1TDRA 4KM0A 2C2TA 5CCCA 4KEBA 1RE7A 1OHJA 4KFJA 3SGYA 4PTHA 3F0VX 3K45A 4DP3A 1RX6A 1S3VA 5FDAA 4HOFA 2W3VA 1DF7A 3F91A 4HA9A 4KY4A 3FRDX 1IA4A 1RX4A 4G8ZX 5EAJA 3F8YA 3JSUA 1DRBA 3DL6A 4LEKX 5CC9A 1BOZA 2INQA 4ELBA 3DATA 4QLGA 2D0KA 4Q67A 2OBCA 4EIGA 3K2HA 3NXOA 5HUIA 4M7VA 1IA3A 3OCHA 3FQCA 4M6JA 3GI2A 4P66A 3QLSA 5HVBA 1J3IA 4LAHX 3S3VA 4Q6AA 4ELHA 1DRHA 3JWMA 3N0HA 1M79A 4Q0DA 3NZDA 1RB2A 1PD9A 4OSGA 5U26A 4QI9A 3SRSX 2HM9A 3FS6A 3NU0A 1RH3A 1SEJA 3DL5A 4G3MA 1DDSA 1DR7A 3TD8A 5E8QA 1DR1A 4KL9A 4PTJA 3FY8X 3JWCA 3SH2A 1RA1A 5ECCA 4ELEA 3KJSA 4X5GA 1RA9A 3UM5A 1RX2A 1QZFA 3R33A 1KMSA 3FY9X 3RO9A 1M78A 1RC4A 3FYWX 1DHFA 3F0BX 3L3RA 4P3QA 3DAUA 2HXVA 3VCOA 3M08A 1ZDRA 3NZBX 3TQAA 3EIGA 3CLBA 3KY8A 3LG4A 5HQYA 5HSUA 3NXVA 3QLZA 3ZPGA 3FQFA 3I3RA 1S3YA 3DG8A 4PDJA 3NXRA 3QLYA 3NXYA 4XT8A 3EX8A 2W3MA 1DLSA 1LY3A 4PSSA 1RX1A 1DR3A 1VJ3A 6DFRA 1RA3A 3QLXA 4GH8A 4G95A 5DFRA 1DISA 1BZFA 3GHWA 3HJ3A 4I13A 4KNEA 3FL9A 3KJRA 4KAKA 3Q1HA 3GYFA 2W9SA 5HSRA 1JUVA 1RX3A 3I8AX 2O7PA 1JOMA 5JA3A 4FGHA 3IA4A 4DFRA 1DRFA 4QJZD 4PSYA 3SRQX 1RF7A 1RX8A 3JWFA 2FZHA 1MVTA 3D80A 1CZ3A 7DFRA 2JYBA 1IA1A 2BLBA 4LAEX 1DDRA 3QG2A 4RGCA 4DPHA 3FQOA 2W3BA 3GHVA 3NXTA 4OR7A 4P3RA 5HVEA 1DLRA 2CIGA 4EJ1A 2DRCA 3UM6A 5JG0X 3FRAX 3F0SX 4QJCA 3F0UX 3CSEA 4H97A 4IXED 1DR4A 1CD2A 3SA1A 4NX7A 5HF0X 1RX9A 3EEKA 4XE6X 1DYRA 2W9HA 3SAIA 4KBNA 4FHBA 1U71A 2W3AA 3FRBX 5DXVA 3QGTA 1DG8A 1RX7A 1S3UA 4XT5A 4KYAA 3JTWA 4XT6A 3QFXA 3ZPCA 1OHKA 4X5IA 4KJLA 1AO8A 4EIZA 1S3WA 2CD2A 4QLEA 1LY4A 5HF2X 5ECXA 1DRAA 3DGAA 2W9TA 4HOGA 4ELGA 3FRFX 3SRWX 4XRBA 3NZ9X 3KFYA 2OIPA 3FQZA 2DHFA 1RA8A 4DDRA 1DIUA 5HT5A 4ELFA 3EELA 3FREX 1RA2A 3S7AA 3FYVX 3QYOA 1MVSA
chains in the Genus database with same CATH topology
1RB3A 4PSTA 4HA7A 1DHIA 4QLFA 2ZZAA 4DPDA 3FQVA 2P4GA 2QK8A 2ITHA 4I1NA 5HI6A 4Q0EA 2G6VA 3QL0A 1DG7A 4EILA 4FGGA 1E26A 1KMVA 1KLKA 1HFPA 8DFRA 4LAGX 3DFRA 3ROAA 1DAJA 1AI9A 3CD2A 5HT4A 4KM2A 3TQ9A 1DR6A 1DR5A 2FZIA 4KJJA 3F0QX 1HFRA 1DYHA 3GHCA 3HBBA 3INVA 3TQBA 3EEJA 4M2XA 1RX5A 4XT7A 1PDBA 2B3ZA 4NX6A 2ANOA 3RG9A 3IRMA 3S9UA 4IXGX 3M09A 3NZCX 2AZNA 1PD8A 4KY8A 3NTZA 3FQ0A 1DYJA 3K74A 3JW5A 5U27A 4KJKA 3TQ8A 2ANQA 1YHOA 2XW7A 4H95A 3EEMA 3NXXA 4X5FA 5HPBA 5HQZA 1DG5A 4XECX 2BL9A 3SQYX 2D5NA 2FZJA 3JVXA 3SR5X 1DYIA 4P68A 4HOEA 1DR2A 3NZ6X 1AOEA 1U72A 1IA2A 3OAFA 2BLAA 4X5HA 3SRUX 2GD9A 3QLWA 3NZAX 3JWKA 2C2SA 4TU5X 4X5JA 2H2QA 1VDRA 1LUDA 3K47A 3FL8A 3IX9A 4QHVA 4M7UA 2KGKA 1DHJA 2LF1A 4ECKA 3IROA 4IXFX 3SRRX 3CL9A 1M7AA 3QLRA 1HFQA 4CD2A 2W9GA 1RG7A 3KGYA 3E0BA 1J3JA 3UM8A 1U70A 2L28A 1DREA 3QL3A 1J3KA 4KD7A 1RD7A 1JOLA 2HQPA 4KLXA 2W3WA 4H98A 3NRRA 3SA2A 3F8ZA 4XT4A 2BLCA 3QYLA 4M6KA 3IRNA 3IA5A 3JW3A 4M6LA 3F0XX 4H96A 3D84X 3DRCA 1D1GA 1TDRA 4KM0A 2C2TA 5CCCA 4KEBA 1RE7A 1OHJA 4KFJA 3SGYA 4PTHA 3F0VX 3K45A 4DP3A 1RX6A 1S3VA 5FDAA 4HOFA 2W3VA 1DF7A 3F91A 4HA9A 4KY4A 3FRDX 1IA4A 1RX4A 4G8ZX 5EAJA 3F8YA 3JSUA 1DRBA 3DL6A 4LEKX 5CC9A 1BOZA 2INQA 4ELBA 3DATA 4QLGA 2D0KA 4Q67A 2OBCA 4EIGA 3K2HA 3NXOA 5HUIA 4M7VA 1IA3A 3OCHA 3FQCA 4M6JA 3GI2A 4P66A 3QLSA 5HVBA 1J3IA 4LAHX 3S3VA 4Q6AA 4ELHA 1DRHA 3JWMA 3N0HA 1M79A 4Q0DA 3NZDA 1RB2A 1PD9A 4OSGA 5U26A 4QI9A 3SRSX 2HM9A 3FS6A 3NU0A 1RH3A 1SEJA 3DL5A 4G3MA 1DDSA 1DR7A 3TD8A 5E8QA 1DR1A 4KL9A 4PTJA 3FY8X 3JWCA 3SH2A 1RA1A 5ECCA 4ELEA 3KJSA 4X5GA 1RA9A 3UM5A 1RX2A 1QZFA 3R33A 1KMSA 3FY9X 3RO9A 1M78A 1RC4A 3FYWX 1DHFA 3F0BX 3L3RA 4P3QA 3DAUA 2HXVA 3VCOA 3M08A 1ZDRA 3NZBX 3TQAA 3EIGA 3CLBA 3KY8A 3LG4A 5HQYA 5HSUA 3NXVA 3QLZA 3ZPGA 3FQFA 3I3RA 1S3YA 3DG8A 4PDJA 3NXRA 3QLYA 3NXYA 4XT8A 3EX8A 2W3MA 1DLSA 1LY3A 4PSSA 1RX1A 1DR3A 1VJ3A 6DFRA 1RA3A 3QLXA 4GH8A 4G95A 5DFRA 1DISA 1BZFA 3GHWA 3HJ3A 4I13A 4KNEA 3FL9A 3KJRA 4KAKA 3Q1HA 3GYFA 2W9SA 5HSRA 1JUVA 1RX3A 3I8AX 2O7PA 1JOMA 5JA3A 4FGHA 3IA4A 4DFRA 1DRFA 4QJZD 4PSYA 3SRQX 1RF7A 1RX8A 3JWFA 2FZHA 1MVTA 3D80A 1CZ3A 7DFRA 2JYBA 1IA1A 2BLBA 4LAEX 1DDRA 3QG2A 4RGCA 4DPHA 3FQOA 2W3BA 3GHVA 3NXTA 4OR7A 4P3RA 5HVEA 1DLRA 2CIGA 4EJ1A 2DRCA 3UM6A 5JG0X 3FRAX 3F0SX 4QJCA 3F0UX 3CSEA 4H97A 4IXED 1DR4A 1CD2A 3SA1A 4NX7A 5HF0X 1RX9A 3EEKA 4XE6X 1DYRA 2W9HA 3SAIA 4KBNA 4FHBA 1U71A 2W3AA 3FRBX 5DXVA 3QGTA 1DG8A 1RX7A 1S3UA 4XT5A 4KYAA 3JTWA 4XT6A 3QFXA 3ZPCA 1OHKA 4X5IA 4KJLA 1AO8A 4EIZA 1S3WA 2CD2A 4QLEA 1LY4A 5HF2X 5ECXA 1DRAA 3DGAA 2W9TA 4HOGA 4ELGA 3FRFX 3SRWX 4XRBA 3NZ9X 3KFYA 2OIPA 3FQZA 2DHFA 1RA8A 4DDRA 1DIUA 5HT5A 4ELFA 3EELA 3FREX 1RA2A 3S7AA 3FYVX 3QYOA 1MVSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RB3 A;  4PST A;  4HA7 A;  1DHI A;  4QLF A;  2ZZA A;  4DPD A;  3FQV A;  2P4G A;  2QK8 A;  2ITH A;  4I1N A;  5HI6 A;  4Q0E A;  2G6V A;  3QL0 A;  1DG7 A;  4EIL A;  4FGG A;  1E26 A;  1KMV A;  1KLK A;  1HFP A;  8DFR A;  4LAG X;  3DFR A;  3ROA A;  1DAJ A;  1AI9 A;  3CD2 A;  5HT4 A;  4KM2 A;  3TQ9 A;  1DR6 A;  1DR5 A;  2FZI A;  4KJJ A;  3F0Q X;  1HFR A;  1DYH A;  3GHC A;  3HBB A;  3INV A;  3TQB A;  3EEJ A;  4M2X A;  1RX5 A;  4XT7 A;  1PDB A;  2B3Z A;  4NX6 A;  2ANO A;  3RG9 A;  3IRM A;  3S9U A;  4IXG X;  3M09 A;  3NZC X;  2AZN A;  1PD8 A;  4KY8 A;  3NTZ A;  3FQ0 A;  1DYJ A;  3K74 A;  3JW5 A;  5U27 A;  4KJK A;  3TQ8 A;  2ANQ A;  1YHO A;  2XW7 A;  4H95 A;  3EEM A;  3NXX A;  4X5F A;  5HPB A;  5HQZ A;  1DG5 A;  4XEC X;  2BL9 A;  3SQY X;  2D5N A;  2FZJ A;  3JVX A;  3SR5 X;  1DYI A;  4P68 A;  4HOE A;  1DR2 A;  3NZ6 X;  1AOE A;  1U72 A;  1IA2 A;  3OAF A;  2BLA A;  4X5H A;  3SRU X;  2GD9 A;  3QLW A;  3NZA X;  3JWK A;  2C2S A;  4TU5 X;  4X5J A;  2H2Q A;  1VDR A;  1LUD A;  3K47 A;  3FL8 A;  3IX9 A;  4QHV A;  4M7U A;  2KGK A;  1DHJ A;  2LF1 A;  4ECK A;  3IRO A;  4IXF X;  3SRR X;  3CL9 A;  1M7A A;  3QLR A;  1HFQ A;  4CD2 A;  2W9G A;  1RG7 A;  3KGY A;  3E0B A;  1J3J A;  3UM8 A;  1U70 A;  2L28 A;  1DRE A;  3QL3 A;  1J3K A;  4KD7 A;  1RD7 A;  1JOL A;  2HQP A;  4KLX A;  2W3W A;  4H98 A;  3NRR A;  3SA2 A;  3F8Z A;  4XT4 A;  2BLC A;  3QYL A;  4M6K A;  3IRN A;  3IA5 A;  3JW3 A;  4M6L A;  3F0X X;  4H96 A;  3D84 X;  3DRC A;  1D1G A;  1TDR A;  4KM0 A;  2C2T A;  5CCC A;  4KEB A;  1RE7 A;  1OHJ A;  4KFJ A;  3SGY A;  4PTH A;  3F0V X;  3K45 A;  4DP3 A;  1RX6 A;  1S3V A;  5FDA A;  4HOF A;  2W3V A;  1DF7 A;  3F91 A;  4HA9 A;  4KY4 A;  3FRD X;  1IA4 A;  1RX4 A;  4G8Z X;  5EAJ A;  3F8Y A;  3JSU A;  1DRB A;  3DL6 A;  4LEK X;  5CC9 A;  1BOZ A;  2INQ A;  4ELB A;  3DAT A;  4QLG A;  2D0K A;  4Q67 A;  2OBC A;  4EIG A;  3K2H A;  3NXO A;  5HUI A;  4M7V A;  1IA3 A;  3OCH A;  3FQC A;  4M6J A;  3GI2 A;  4P66 A;  3QLS A;  5HVB A;  1J3I A;  4LAH X;  3S3V A;  4Q6A A;  4ELH A;  1DRH A;  3JWM A;  3N0H A;  1M79 A;  4Q0D A;  3NZD A;  1RB2 A;  1PD9 A;  4OSG A;  5U26 A;  4QI9 A;  3SRS X;  2HM9 A;  3FS6 A;  3NU0 A;  1RH3 A;  1SEJ A;  3DL5 A;  4G3M A;  1DDS A;  1DR7 A;  3TD8 A;  5E8Q A;  1DR1 A;  4KL9 A;  4PTJ A;  3FY8 X;  3JWC A;  3SH2 A;  1RA1 A;  5ECC A;  4ELE A;  3KJS A;  4X5G A;  1RA9 A;  3UM5 A;  1RX2 A;  1QZF A;  3R33 A;  1KMS A;  3FY9 X;  3RO9 A;  1M78 A;  1RC4 A;  3FYW X;  1DHF A;  3F0B X;  3L3R A;  4P3Q A;  3DAU A;  2HXV A;  3VCO A;  3M08 A;  1ZDR A;  3NZB X;  3TQA A;  3EIG A;  3CLB A;  3KY8 A;  3LG4 A;  5HQY A;  5HSU A;  3NXV A;  3QLZ A;  3ZPG A;  3FQF A;  3I3R A;  1S3Y A;  3DG8 A;  4PDJ A;  3NXR A;  3QLY A;  3NXY A;  4XT8 A;  3EX8 A;  2W3M A;  1DLS A;  1LY3 A;  4PSS A;  1RX1 A;  1DR3 A;  1VJ3 A;  6DFR A;  1RA3 A;  3QLX A;  4GH8 A;  4G95 A;  5DFR A;  1DIS A;  1BZF A;  3GHW A;  3HJ3 A;  4I13 A;  4KNE A;  3FL9 A;  3KJR A;  4KAK A;  3Q1H A;  3GYF A;  2W9S A;  5HSR A;  1JUV A;  1RX3 A;  3I8A X;  2O7P A;  1JOM A;  5JA3 A;  4FGH A;  3IA4 A;  4DFR A;  1DRF A;  4QJZ D;  4PSY A;  3SRQ X;  1RF7 A;  1RX8 A;  3JWF A;  2FZH A;  1MVT A;  3D80 A;  1CZ3 A;  7DFR A;  2JYB A;  1IA1 A;  2BLB A;  4LAE X;  1DDR A;  3QG2 A;  4RGC A;  4DPH A;  3FQO A;  2W3B A;  3GHV A;  3NXT A;  4OR7 A;  4P3R A;  5HVE A;  1DLR A;  2CIG A;  4EJ1 A;  2DRC A;  3UM6 A;  5JG0 X;  3FRA X;  3F0S X;  4QJC A;  3F0U X;  3CSE A;  4H97 A;  4IXE D;  1DR4 A;  1CD2 A;  3SA1 A;  4NX7 A;  5HF0 X;  1RX9 A;  3EEK A;  4XE6 X;  1DYR A;  2W9H A;  3SAI A;  4KBN A;  4FHB A;  1U71 A;  2W3A A;  3FRB X;  5DXV A;  3QGT A;  1DG8 A;  1RX7 A;  1S3U A;  4XT5 A;  4KYA A;  3JTW A;  4XT6 A;  3QFX A;  3ZPC A;  1OHK A;  4X5I A;  4KJL A;  1AO8 A;  4EIZ A;  1S3W A;  2CD2 A;  4QLE A;  1LY4 A;  5HF2 X;  5ECX A;  1DRA A;  3DGA A;  2W9T A;  4HOG A;  4ELG A;  3FRF X;  3SRW X;  4XRB A;  3NZ9 X;  3KFY A;  2OIP A;  3FQZ A;  2DHF A;  1RA8 A;  4DDR A;  1DIU A;  5HT5 A;  4ELF A;  3EEL A;  3FRE X;  1RA2 A;  3S7A A;  3FYV X;  3QYO A;  1MVS A; 
#chains in the Genus database with same CATH topology
 1RB3 A;  4PST A;  4HA7 A;  1DHI A;  4QLF A;  2ZZA A;  4DPD A;  3FQV A;  2P4G A;  2QK8 A;  2ITH A;  4I1N A;  5HI6 A;  4Q0E A;  2G6V A;  3QL0 A;  1DG7 A;  4EIL A;  4FGG A;  1E26 A;  1KMV A;  1KLK A;  1HFP A;  8DFR A;  4LAG X;  3DFR A;  3ROA A;  1DAJ A;  1AI9 A;  3CD2 A;  5HT4 A;  4KM2 A;  3TQ9 A;  1DR6 A;  1DR5 A;  2FZI A;  4KJJ A;  3F0Q X;  1HFR A;  1DYH A;  3GHC A;  3HBB A;  3INV A;  3TQB A;  3EEJ A;  4M2X A;  1RX5 A;  4XT7 A;  1PDB A;  2B3Z A;  4NX6 A;  2ANO A;  3RG9 A;  3IRM A;  3S9U A;  4IXG X;  3M09 A;  3NZC X;  2AZN A;  1PD8 A;  4KY8 A;  3NTZ A;  3FQ0 A;  1DYJ A;  3K74 A;  3JW5 A;  5U27 A;  4KJK A;  3TQ8 A;  2ANQ A;  1YHO A;  2XW7 A;  4H95 A;  3EEM A;  3NXX A;  4X5F A;  5HPB A;  5HQZ A;  1DG5 A;  4XEC X;  2BL9 A;  3SQY X;  2D5N A;  2FZJ A;  3JVX A;  3SR5 X;  1DYI A;  4P68 A;  4HOE A;  1DR2 A;  3NZ6 X;  1AOE A;  1U72 A;  1IA2 A;  3OAF A;  2BLA A;  4X5H A;  3SRU X;  2GD9 A;  3QLW A;  3NZA X;  3JWK A;  2C2S A;  4TU5 X;  4X5J A;  2H2Q A;  1VDR A;  1LUD A;  3K47 A;  3FL8 A;  3IX9 A;  4QHV A;  4M7U A;  2KGK A;  1DHJ A;  2LF1 A;  4ECK A;  3IRO A;  4IXF X;  3SRR X;  3CL9 A;  1M7A A;  3QLR A;  1HFQ A;  4CD2 A;  2W9G A;  1RG7 A;  3KGY A;  3E0B A;  1J3J A;  3UM8 A;  1U70 A;  2L28 A;  1DRE A;  3QL3 A;  1J3K A;  4KD7 A;  1RD7 A;  1JOL A;  2HQP A;  4KLX A;  2W3W A;  4H98 A;  3NRR A;  3SA2 A;  3F8Z A;  4XT4 A;  2BLC A;  3QYL A;  4M6K A;  3IRN A;  3IA5 A;  3JW3 A;  4M6L A;  3F0X X;  4H96 A;  3D84 X;  3DRC A;  1D1G A;  1TDR A;  4KM0 A;  2C2T A;  5CCC A;  4KEB A;  1RE7 A;  1OHJ A;  4KFJ A;  3SGY A;  4PTH A;  3F0V X;  3K45 A;  4DP3 A;  1RX6 A;  1S3V A;  5FDA A;  4HOF A;  2W3V A;  1DF7 A;  3F91 A;  4HA9 A;  4KY4 A;  3FRD X;  1IA4 A;  1RX4 A;  4G8Z X;  5EAJ A;  3F8Y A;  3JSU A;  1DRB A;  3DL6 A;  4LEK X;  5CC9 A;  1BOZ A;  2INQ A;  4ELB A;  3DAT A;  4QLG A;  2D0K A;  4Q67 A;  2OBC A;  4EIG A;  3K2H A;  3NXO A;  5HUI A;  4M7V A;  1IA3 A;  3OCH A;  3FQC A;  4M6J A;  3GI2 A;  4P66 A;  3QLS A;  5HVB A;  1J3I A;  4LAH X;  3S3V A;  4Q6A A;  4ELH A;  1DRH A;  3JWM A;  3N0H A;  1M79 A;  4Q0D A;  3NZD A;  1RB2 A;  1PD9 A;  4OSG A;  5U26 A;  4QI9 A;  3SRS X;  2HM9 A;  3FS6 A;  3NU0 A;  1RH3 A;  1SEJ A;  3DL5 A;  4G3M A;  1DDS A;  1DR7 A;  3TD8 A;  5E8Q A;  1DR1 A;  4KL9 A;  4PTJ A;  3FY8 X;  3JWC A;  3SH2 A;  1RA1 A;  5ECC A;  4ELE A;  3KJS A;  4X5G A;  1RA9 A;  3UM5 A;  1RX2 A;  1QZF A;  3R33 A;  1KMS A;  3FY9 X;  3RO9 A;  1M78 A;  1RC4 A;  3FYW X;  1DHF A;  3F0B X;  3L3R A;  4P3Q A;  3DAU A;  2HXV A;  3VCO A;  3M08 A;  1ZDR A;  3NZB X;  3TQA A;  3EIG A;  3CLB A;  3KY8 A;  3LG4 A;  5HQY A;  5HSU A;  3NXV A;  3QLZ A;  3ZPG A;  3FQF A;  3I3R A;  1S3Y A;  3DG8 A;  4PDJ A;  3NXR A;  3QLY A;  3NXY A;  4XT8 A;  3EX8 A;  2W3M A;  1DLS A;  1LY3 A;  4PSS A;  1RX1 A;  1DR3 A;  1VJ3 A;  6DFR A;  1RA3 A;  3QLX A;  4GH8 A;  4G95 A;  5DFR A;  1DIS A;  1BZF A;  3GHW A;  3HJ3 A;  4I13 A;  4KNE A;  3FL9 A;  3KJR A;  4KAK A;  3Q1H A;  3GYF A;  2W9S A;  5HSR A;  1JUV A;  1RX3 A;  3I8A X;  2O7P A;  1JOM A;  5JA3 A;  4FGH A;  3IA4 A;  4DFR A;  1DRF A;  4QJZ D;  4PSY A;  3SRQ X;  1RF7 A;  1RX8 A;  3JWF A;  2FZH A;  1MVT A;  3D80 A;  1CZ3 A;  7DFR A;  2JYB A;  1IA1 A;  2BLB A;  4LAE X;  1DDR A;  3QG2 A;  4RGC A;  4DPH A;  3FQO A;  2W3B A;  3GHV A;  3NXT A;  4OR7 A;  4P3R A;  5HVE A;  1DLR A;  2CIG A;  4EJ1 A;  2DRC A;  3UM6 A;  5JG0 X;  3FRA X;  3F0S X;  4QJC A;  3F0U X;  3CSE A;  4H97 A;  4IXE D;  1DR4 A;  1CD2 A;  3SA1 A;  4NX7 A;  5HF0 X;  1RX9 A;  3EEK A;  4XE6 X;  1DYR A;  2W9H A;  3SAI A;  4KBN A;  4FHB A;  1U71 A;  2W3A A;  3FRB X;  5DXV A;  3QGT A;  1DG8 A;  1RX7 A;  1S3U A;  4XT5 A;  4KYA A;  3JTW A;  4XT6 A;  3QFX A;  3ZPC A;  1OHK A;  4X5I A;  4KJL A;  1AO8 A;  4EIZ A;  1S3W A;  2CD2 A;  4QLE A;  1LY4 A;  5HF2 X;  5ECX A;  1DRA A;  3DGA A;  2W9T A;  4HOG A;  4ELG A;  3FRF X;  3SRW X;  4XRB A;  3NZ9 X;  3KFY A;  2OIP A;  3FQZ A;  2DHF A;  1RA8 A;  4DDR A;  1DIU A;  5HT5 A;  4ELF A;  3EEL A;  3FRE X;  1RA2 A;  3S7A A;  3FYV X;  3QYO A;  1MVS A; 
#chains in the Genus database with same CATH homology
 1RB3 A;  4PST A;  4HA7 A;  1DHI A;  4QLF A;  2ZZA A;  4DPD A;  3FQV A;  2P4G A;  2QK8 A;  2ITH A;  4I1N A;  5HI6 A;  4Q0E A;  2G6V A;  3QL0 A;  1DG7 A;  4EIL A;  4FGG A;  1E26 A;  1KMV A;  1KLK A;  1HFP A;  8DFR A;  4LAG X;  3DFR A;  3ROA A;  1DAJ A;  1AI9 A;  3CD2 A;  5HT4 A;  4KM2 A;  3TQ9 A;  1DR6 A;  1DR5 A;  2FZI A;  4KJJ A;  3F0Q X;  1HFR A;  1DYH A;  3GHC A;  3HBB A;  3INV A;  3TQB A;  3EEJ A;  4M2X A;  1RX5 A;  4XT7 A;  1PDB A;  2B3Z A;  4NX6 A;  2ANO A;  3RG9 A;  3IRM A;  3S9U A;  4IXG X;  3M09 A;  3NZC X;  2AZN A;  1PD8 A;  4KY8 A;  3NTZ A;  3FQ0 A;  1DYJ A;  3K74 A;  3JW5 A;  5U27 A;  4KJK A;  3TQ8 A;  2ANQ A;  1YHO A;  2XW7 A;  4H95 A;  3EEM A;  3NXX A;  4X5F A;  5HPB A;  5HQZ A;  1DG5 A;  4XEC X;  2BL9 A;  3SQY X;  2D5N A;  2FZJ A;  3JVX A;  3SR5 X;  1DYI A;  4P68 A;  4HOE A;  1DR2 A;  3NZ6 X;  1AOE A;  1U72 A;  1IA2 A;  3OAF A;  2BLA A;  4X5H A;  3SRU X;  2GD9 A;  3QLW A;  3NZA X;  3JWK A;  2C2S A;  4TU5 X;  4X5J A;  2H2Q A;  1VDR A;  1LUD A;  3K47 A;  3FL8 A;  3IX9 A;  4QHV A;  4M7U A;  2KGK A;  1DHJ A;  2LF1 A;  4ECK A;  3IRO A;  4IXF X;  3SRR X;  3CL9 A;  1M7A A;  3QLR A;  1HFQ A;  4CD2 A;  2W9G A;  1RG7 A;  3KGY A;  3E0B A;  1J3J A;  3UM8 A;  1U70 A;  2L28 A;  1DRE A;  3QL3 A;  1J3K A;  4KD7 A;  1RD7 A;  1JOL A;  2HQP A;  4KLX A;  2W3W A;  4H98 A;  3NRR A;  3SA2 A;  3F8Z A;  4XT4 A;  2BLC A;  3QYL A;  4M6K A;  3IRN A;  3IA5 A;  3JW3 A;  4M6L A;  3F0X X;  4H96 A;  3D84 X;  3DRC A;  1D1G A;  1TDR A;  4KM0 A;  2C2T A;  5CCC A;  4KEB A;  1RE7 A;  1OHJ A;  4KFJ A;  3SGY A;  4PTH A;  3F0V X;  3K45 A;  4DP3 A;  1RX6 A;  1S3V A;  5FDA A;  4HOF A;  2W3V A;  1DF7 A;  3F91 A;  4HA9 A;  4KY4 A;  3FRD X;  1IA4 A;  1RX4 A;  4G8Z X;  5EAJ A;  3F8Y A;  3JSU A;  1DRB A;  3DL6 A;  4LEK X;  5CC9 A;  1BOZ A;  2INQ A;  4ELB A;  3DAT A;  4QLG A;  2D0K A;  4Q67 A;  2OBC A;  4EIG A;  3K2H A;  3NXO A;  5HUI A;  4M7V A;  1IA3 A;  3OCH A;  3FQC A;  4M6J A;  3GI2 A;  4P66 A;  3QLS A;  5HVB A;  1J3I A;  4LAH X;  3S3V A;  4Q6A A;  4ELH A;  1DRH A;  3JWM A;  3N0H A;  1M79 A;  4Q0D A;  3NZD A;  1RB2 A;  1PD9 A;  4OSG A;  5U26 A;  4QI9 A;  3SRS X;  2HM9 A;  3FS6 A;  3NU0 A;  1RH3 A;  1SEJ A;  3DL5 A;  4G3M A;  1DDS A;  1DR7 A;  3TD8 A;  5E8Q A;  1DR1 A;  4KL9 A;  4PTJ A;  3FY8 X;  3JWC A;  3SH2 A;  1RA1 A;  5ECC A;  4ELE A;  3KJS A;  4X5G A;  1RA9 A;  3UM5 A;  1RX2 A;  1QZF A;  3R33 A;  1KMS A;  3FY9 X;  3RO9 A;  1M78 A;  1RC4 A;  3FYW X;  1DHF A;  3F0B X;  3L3R A;  4P3Q A;  3DAU A;  2HXV A;  3VCO A;  3M08 A;  1ZDR A;  3NZB X;  3TQA A;  3EIG A;  3CLB A;  3KY8 A;  3LG4 A;  5HQY A;  5HSU A;  3NXV A;  3QLZ A;  3ZPG A;  3FQF A;  3I3R A;  1S3Y A;  3DG8 A;  4PDJ A;  3NXR A;  3QLY A;  3NXY A;  4XT8 A;  3EX8 A;  2W3M A;  1DLS A;  1LY3 A;  4PSS A;  1RX1 A;  1DR3 A;  1VJ3 A;  6DFR A;  1RA3 A;  3QLX A;  4GH8 A;  4G95 A;  5DFR A;  1DIS A;  1BZF A;  3GHW A;  3HJ3 A;  4I13 A;  4KNE A;  3FL9 A;  3KJR A;  4KAK A;  3Q1H A;  3GYF A;  2W9S A;  5HSR A;  1JUV A;  1RX3 A;  3I8A X;  2O7P A;  1JOM A;  5JA3 A;  4FGH A;  3IA4 A;  4DFR A;  1DRF A;  4QJZ D;  4PSY A;  3SRQ X;  1RF7 A;  1RX8 A;  3JWF A;  2FZH A;  1MVT A;  3D80 A;  1CZ3 A;  7DFR A;  2JYB A;  1IA1 A;  2BLB A;  4LAE X;  1DDR A;  3QG2 A;  4RGC A;  4DPH A;  3FQO A;  2W3B A;  3GHV A;  3NXT A;  4OR7 A;  4P3R A;  5HVE A;  1DLR A;  2CIG A;  4EJ1 A;  2DRC A;  3UM6 A;  5JG0 X;  3FRA X;  3F0S X;  4QJC A;  3F0U X;  3CSE A;  4H97 A;  4IXE D;  1DR4 A;  1CD2 A;  3SA1 A;  4NX7 A;  5HF0 X;  1RX9 A;  3EEK A;  4XE6 X;  1DYR A;  2W9H A;  3SAI A;  4KBN A;  4FHB A;  1U71 A;  2W3A A;  3FRB X;  5DXV A;  3QGT A;  1DG8 A;  1RX7 A;  1S3U A;  4XT5 A;  4KYA A;  3JTW A;  4XT6 A;  3QFX A;  3ZPC A;  1OHK A;  4X5I A;  4KJL A;  1AO8 A;  4EIZ A;  1S3W A;  2CD2 A;  4QLE A;  1LY4 A;  5HF2 X;  5ECX A;  1DRA A;  3DGA A;  2W9T A;  4HOG A;  4ELG A;  3FRF X;  3SRW X;  4XRB A;  3NZ9 X;  3KFY A;  2OIP A;  3FQZ A;  2DHF A;  1RA8 A;  4DDR A;  1DIU A;  5HT5 A;  4ELF A;  3EEL A;  3FRE X;  1RA2 A;  3S7A A;  3FYV X;  3QYO A;  1MVS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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