5HQZA

Fluorine substituted 5-methyl-6-(4'-trifluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines
rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 55
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-01-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5hqzA00
4G95A 4P68A 3IRNA 1DLSA 2W3AA 3GHCA 4KNEA 3FL8A 3SA1A 3S3VA 3K45A 2LF1A 3OCHA 1DYIA 2HXVA 1RX8A 1MVSA 3DAUA 1DIUA 4DFRA 1DF7A 1M79A 4XE6X 3NTZA 1CD2A 3GHVA 3FL9A 2W9TA 3F0BX 5HVEA 4KY8A 1HFPA 4QI9A 1KMVA 3CL9A 2ANQA 3EEKA 4PSYA 5EAJA 1RX3A 5HT4A 2P4GA 3QYOA 3F0SX 3FY8X 3IROA 4KD7A 1E26A 1DR6A 1DRBA 3UM6A 4LAHX 2BLAA 3K2HA 3F91A 3TQBA 4IXFX 2BL9A 2HM9A 3N0HA 1IA3A 4OSGA 4PDJA 3TD8A 2FZIA 4DP3A 3Q1HA 1DG5A 1RH3A 3FQ0A 3QFXA 4Q0DA 4XT8A 3LG4A 4PSTA 3TQ8A 3TQAA 3DG8A 1DR5A 3JTWA 5FDAA 2H2QA 1DRAA 5CC9A 1DAJA 5HPBA 1IA1A 2W3MA 2B3ZA 4M7UA 3EEMA 3FYVX 1AOEA 4QJCA 3FQOA 4ELGA 1BZFA 3KFYA 1KMSA 2O7PA 5U26A 3NXVA 4EJ1A 5HI6A 1DLRA 4XT4A 4M6LA 4QLFA 2CD2A 4QHVA 3SRRX 1M78A 5HUIA 3NZBX 3GI2A 4M7VA 1TDRA 3EX8A 3NZ6X 3GYFA 1LY3A 1DR1A 1BOZA 1RX7A 1RA2A 1S3UA 3FRFX 4KM2A 3IRMA 1S3WA 1DG7A 1PD9A 4KM0A 1QZFA 3RG9A 5ECCA 1HFRA 3E0BA 4FGHA 4HA9A 4Q67A 2ZZAA 4H97A 3INVA 4EIZA 4G8ZX 2OBCA 5HT5A 1JOMA 3QLZA 1RA9A 4KEBA 1PDBA 3SA2A 2W3VA 4ELEA 3SQYX 4X5FA 4P66A 1RX2A 4NX6A 3SGYA 4KJKA 3QL0A 4NX7A 5HQYA 1HFQA 3CD2A 1ZDRA 1CZ3A 3SH2A 3NXOA 2C2TA 2GD9A 4M6JA 1DG8A 4KY4A 1JUVA 3KJSA 4PTJA 4P3RA 3IA5A 1DYRA 1IA2A 4ELFA 3FRAX 1VJ3A 3ROAA 1DDRA 3UM8A 1DHIA 4EILA 2L28A 4FHBA 3SR5X 3QGTA 3I8AX 4LEKX 3GHWA 4OR7A 4XRBA 3S9UA 3QG2A 2KGKA 3I3RA 4KAKA 4QJZD 4X5HA 1AI9A 3KY8A 3D84X 4Q6AA 4CD2A 3M09A 3JW3A 4HOEA 1S3YA 2OIPA 4KL9A 1DRFA 2FZHA 4KYAA 1DRHA 1U70A 3F0QX 2DHFA 8DFRA 4Q0EA 3FS6A 3S7AA 5U27A 2W9GA 3FYWX 4HOGA 5HSUA 1RA3A 1RX6A 3EIGA 1YHOA 1MVTA 3JW5A 3L3RA 1RC4A 4X5IA 1DR3A 4LAEX 1U71A 1DYHA 3QLSA 1RX9A 1RG7A 3IA4A 3NXRA 3TQ9A 4X5JA 1J3JA 4DPDA 4P3QA 1DHJA 4XT5A 1DR2A 2D0KA 2HQPA 1RD7A 2JYBA 5DFRA 7DFRA 5JG0X 3F0VX 3ZPGA 1DISA 3VCOA 2D5NA 3FQCA 5HF2X 5HF0X 1RX4A 3JWFA 3EELA 4DPHA 3NXXA 3DATA 3F0XX 4M2XA 4ECKA 2W3WA 1PD8A 3F8YA 3R33A 1RA1A 3FQZA 4HOFA 4KLXA 5HVBA 1JOLA 2G6VA 1OHKA 2CIGA 3NZ9X 3JWCA 3JWMA 1DR4A 3ZPCA 5HSRA 4KBNA 2AZNA 3M08A 4XECX 4KJLA 4RGCA 3SRSX 4XT6A 3IX9A 3QL3A 3CSEA 3F0UX 1AO8A 4I1NA 4EIGA 4FGGA 3NXYA 1DYJA 4TU5X 1RX1A 4HA7A 3JVXA 1LY4A 3FRDX 3NZAX 4H95A 1LUDA 4PTHA 2XW7A 1IA4A 4X5GA 1J3KA 4KFJA 3EEJA 1RB3A 3K47A 2DRCA 3HJ3A 3NU0A 3DFRA 2QK8A 3F8ZA 2FZJA 3OAFA 5JA3A 3HBBA 1S3VA 3SRQX 5DXVA 1DR7A 4DDRA 4ELBA 4PSSA 2BLCA 3JWKA 6DFRA 1RX5A 4G3MA 3UM5A 1U72A 3NRRA 1OHJA 3DL5A 2BLBA 4H96A 5HQZA 3FQVA 3FY9X 2W9SA 2ANOA 4QLGA 1SEJA 3KJRA 4I13A 5CCCA 1J3IA 3DL6A 3KGYA 1DDSA 3SRUX 5E8QA 2INQA 3QLRA 1VDRA 5ECXA 1D1GA 1RE7A 3FQFA 2C2SA 3DRCA 3QLXA 3FRBX 2W9HA 3FREX 4LAGX 1KLKA 3CLBA 1RF7A 3NZDA 4KJJA 3D80A 4GH8A 1RA8A 4IXGX 2W3BA 3DGAA 3SRWX 4QLEA 1M7AA 1DHFA 3NXTA 4M6KA 4IXED 3SAIA 3QYLA 1RB2A 4XT7A 3K74A 1DREA 4H98A 2ITHA 3JSUA 3RO9A 3QLWA 4ELHA 3NZCX 3QLYA
chains in the Genus database with same CATH superfamily
4G95A 4P68A 3IRNA 1DLSA 2W3AA 3GHCA 4KNEA 3FL8A 3SA1A 3S3VA 3K45A 2LF1A 3OCHA 1DYIA 2HXVA 1RX8A 1MVSA 3DAUA 1DIUA 4DFRA 1DF7A 1M79A 4XE6X 3NTZA 1CD2A 3GHVA 3FL9A 2W9TA 3F0BX 5HVEA 4KY8A 1HFPA 4QI9A 1KMVA 3CL9A 2ANQA 3EEKA 4PSYA 5EAJA 1RX3A 5HT4A 2P4GA 3QYOA 3F0SX 3FY8X 3IROA 4KD7A 1E26A 1DR6A 1DRBA 3UM6A 4LAHX 2BLAA 3K2HA 3F91A 3TQBA 4IXFX 2BL9A 2HM9A 3N0HA 1IA3A 4OSGA 4PDJA 3TD8A 2FZIA 4DP3A 3Q1HA 1DG5A 1RH3A 3FQ0A 3QFXA 4Q0DA 4XT8A 3LG4A 4PSTA 3TQ8A 3TQAA 3DG8A 1DR5A 3JTWA 5FDAA 2H2QA 1DRAA 5CC9A 1DAJA 5HPBA 1IA1A 2W3MA 2B3ZA 4M7UA 3EEMA 3FYVX 1AOEA 4QJCA 3FQOA 4ELGA 1BZFA 3KFYA 1KMSA 2O7PA 5U26A 3NXVA 4EJ1A 5HI6A 1DLRA 4XT4A 4M6LA 4QLFA 2CD2A 4QHVA 3SRRX 1M78A 5HUIA 3NZBX 3GI2A 4M7VA 1TDRA 3EX8A 3NZ6X 3GYFA 1LY3A 1DR1A 1BOZA 1RX7A 1RA2A 1S3UA 3FRFX 4KM2A 3IRMA 1S3WA 1DG7A 1PD9A 4KM0A 1QZFA 3RG9A 5ECCA 1HFRA 3E0BA 4FGHA 4HA9A 4Q67A 2ZZAA 4H97A 3INVA 4EIZA 4G8ZX 2OBCA 5HT5A 1JOMA 3QLZA 1RA9A 4KEBA 1PDBA 3SA2A 2W3VA 4ELEA 3SQYX 4X5FA 4P66A 1RX2A 4NX6A 3SGYA 4KJKA 3QL0A 4NX7A 5HQYA 1HFQA 3CD2A 1ZDRA 1CZ3A 3SH2A 3NXOA 2C2TA 2GD9A 4M6JA 1DG8A 4KY4A 1JUVA 3KJSA 4PTJA 4P3RA 3IA5A 1DYRA 1IA2A 4ELFA 3FRAX 1VJ3A 3ROAA 1DDRA 3UM8A 1DHIA 4EILA 2L28A 4FHBA 3SR5X 3QGTA 3I8AX 4LEKX 3GHWA 4OR7A 4XRBA 3S9UA 3QG2A 2KGKA 3I3RA 4KAKA 4QJZD 4X5HA 1AI9A 3KY8A 3D84X 4Q6AA 4CD2A 3M09A 3JW3A 4HOEA 1S3YA 2OIPA 4KL9A 1DRFA 2FZHA 4KYAA 1DRHA 1U70A 3F0QX 2DHFA 8DFRA 4Q0EA 3FS6A 3S7AA 5U27A 2W9GA 3FYWX 4HOGA 5HSUA 1RA3A 1RX6A 3EIGA 1YHOA 1MVTA 3JW5A 3L3RA 1RC4A 4X5IA 1DR3A 4LAEX 1U71A 1DYHA 3QLSA 1RX9A 1RG7A 3IA4A 3NXRA 3TQ9A 4X5JA 1J3JA 4DPDA 4P3QA 1DHJA 4XT5A 1DR2A 2D0KA 2HQPA 1RD7A 2JYBA 5DFRA 7DFRA 5JG0X 3F0VX 3ZPGA 1DISA 3VCOA 2D5NA 3FQCA 5HF2X 5HF0X 1RX4A 3JWFA 3EELA 4DPHA 3NXXA 3DATA 3F0XX 4M2XA 4ECKA 2W3WA 1PD8A 3F8YA 3R33A 1RA1A 3FQZA 4HOFA 4KLXA 5HVBA 1JOLA 2G6VA 1OHKA 2CIGA 3NZ9X 3JWCA 3JWMA 1DR4A 3ZPCA 5HSRA 4KBNA 2AZNA 3M08A 4XECX 4KJLA 4RGCA 3SRSX 4XT6A 3IX9A 3QL3A 3CSEA 3F0UX 1AO8A 4I1NA 4EIGA 4FGGA 3NXYA 1DYJA 4TU5X 1RX1A 4HA7A 3JVXA 1LY4A 3FRDX 3NZAX 4H95A 1LUDA 4PTHA 2XW7A 1IA4A 4X5GA 1J3KA 4KFJA 3EEJA 1RB3A 3K47A 2DRCA 3HJ3A 3NU0A 3DFRA 2QK8A 3F8ZA 2FZJA 3OAFA 5JA3A 3HBBA 1S3VA 3SRQX 5DXVA 1DR7A 4DDRA 4ELBA 4PSSA 2BLCA 3JWKA 6DFRA 1RX5A 4G3MA 3UM5A 1U72A 3NRRA 1OHJA 3DL5A 2BLBA 4H96A 5HQZA 3FQVA 3FY9X 2W9SA 2ANOA 4QLGA 1SEJA 3KJRA 4I13A 5CCCA 1J3IA 3DL6A 3KGYA 1DDSA 3SRUX 5E8QA 2INQA 3QLRA 1VDRA 5ECXA 1D1GA 1RE7A 3FQFA 2C2SA 3DRCA 3QLXA 3FRBX 2W9HA 3FREX 4LAGX 1KLKA 3CLBA 1RF7A 3NZDA 4KJJA 3D80A 4GH8A 1RA8A 4IXGX 2W3BA 3DGAA 3SRWX 4QLEA 1M7AA 1DHFA 3NXTA 4M6KA 4IXED 3SAIA 3QYLA 1RB2A 4XT7A 3K74A 1DREA 4H98A 2ITHA 3JSUA 3RO9A 3QLWA 4ELHA 3NZCX 3QLYA
chains in the Genus database with same CATH topology
4G95A 4P68A 3IRNA 1DLSA 2W3AA 3GHCA 4KNEA 3FL8A 3SA1A 3S3VA 3K45A 2LF1A 3OCHA 1DYIA 2HXVA 1RX8A 1MVSA 3DAUA 1DIUA 4DFRA 1DF7A 1M79A 4XE6X 3NTZA 1CD2A 3GHVA 3FL9A 2W9TA 3F0BX 5HVEA 4KY8A 1HFPA 4QI9A 1KMVA 3CL9A 2ANQA 3EEKA 4PSYA 5EAJA 1RX3A 5HT4A 2P4GA 3QYOA 3F0SX 3FY8X 3IROA 4KD7A 1E26A 1DR6A 1DRBA 3UM6A 4LAHX 2BLAA 3K2HA 3F91A 3TQBA 4IXFX 2BL9A 2HM9A 3N0HA 1IA3A 4OSGA 4PDJA 3TD8A 2FZIA 4DP3A 3Q1HA 1DG5A 1RH3A 3FQ0A 3QFXA 4Q0DA 4XT8A 3LG4A 4PSTA 3TQ8A 3TQAA 3DG8A 1DR5A 3JTWA 5FDAA 2H2QA 1DRAA 5CC9A 1DAJA 5HPBA 1IA1A 2W3MA 2B3ZA 4M7UA 3EEMA 3FYVX 1AOEA 4QJCA 3FQOA 4ELGA 1BZFA 3KFYA 1KMSA 2O7PA 5U26A 3NXVA 4EJ1A 5HI6A 1DLRA 4XT4A 4M6LA 4QLFA 2CD2A 4QHVA 3SRRX 1M78A 5HUIA 3NZBX 3GI2A 4M7VA 1TDRA 3EX8A 3NZ6X 3GYFA 1LY3A 1DR1A 1BOZA 1RX7A 1RA2A 1S3UA 3FRFX 4KM2A 3IRMA 1S3WA 1DG7A 1PD9A 4KM0A 1QZFA 3RG9A 5ECCA 1HFRA 3E0BA 4FGHA 4HA9A 4Q67A 2ZZAA 4H97A 3INVA 4EIZA 4G8ZX 2OBCA 5HT5A 1JOMA 3QLZA 1RA9A 4KEBA 1PDBA 3SA2A 2W3VA 4ELEA 3SQYX 4X5FA 4P66A 1RX2A 4NX6A 3SGYA 4KJKA 3QL0A 4NX7A 5HQYA 1HFQA 3CD2A 1ZDRA 1CZ3A 3SH2A 3NXOA 2C2TA 2GD9A 4M6JA 1DG8A 4KY4A 1JUVA 3KJSA 4PTJA 4P3RA 3IA5A 1DYRA 1IA2A 4ELFA 3FRAX 1VJ3A 3ROAA 1DDRA 3UM8A 1DHIA 4EILA 2L28A 4FHBA 3SR5X 3QGTA 3I8AX 4LEKX 3GHWA 4OR7A 4XRBA 3S9UA 3QG2A 2KGKA 3I3RA 4KAKA 4QJZD 4X5HA 1AI9A 3KY8A 3D84X 4Q6AA 4CD2A 3M09A 3JW3A 4HOEA 1S3YA 2OIPA 4KL9A 1DRFA 2FZHA 4KYAA 1DRHA 1U70A 3F0QX 2DHFA 8DFRA 4Q0EA 3FS6A 3S7AA 5U27A 2W9GA 3FYWX 4HOGA 5HSUA 1RA3A 1RX6A 3EIGA 1YHOA 1MVTA 3JW5A 3L3RA 1RC4A 4X5IA 1DR3A 4LAEX 1U71A 1DYHA 3QLSA 1RX9A 1RG7A 3IA4A 3NXRA 3TQ9A 4X5JA 1J3JA 4DPDA 4P3QA 1DHJA 4XT5A 1DR2A 2D0KA 2HQPA 1RD7A 2JYBA 5DFRA 7DFRA 5JG0X 3F0VX 3ZPGA 1DISA 3VCOA 2D5NA 3FQCA 5HF2X 5HF0X 1RX4A 3JWFA 3EELA 4DPHA 3NXXA 3DATA 3F0XX 4M2XA 4ECKA 2W3WA 1PD8A 3F8YA 3R33A 1RA1A 3FQZA 4HOFA 4KLXA 5HVBA 1JOLA 2G6VA 1OHKA 2CIGA 3NZ9X 3JWCA 3JWMA 1DR4A 3ZPCA 5HSRA 4KBNA 2AZNA 3M08A 4XECX 4KJLA 4RGCA 3SRSX 4XT6A 3IX9A 3QL3A 3CSEA 3F0UX 1AO8A 4I1NA 4EIGA 4FGGA 3NXYA 1DYJA 4TU5X 1RX1A 4HA7A 3JVXA 1LY4A 3FRDX 3NZAX 4H95A 1LUDA 4PTHA 2XW7A 1IA4A 4X5GA 1J3KA 4KFJA 3EEJA 1RB3A 3K47A 2DRCA 3HJ3A 3NU0A 3DFRA 2QK8A 3F8ZA 2FZJA 3OAFA 5JA3A 3HBBA 1S3VA 3SRQX 5DXVA 1DR7A 4DDRA 4ELBA 4PSSA 2BLCA 3JWKA 6DFRA 1RX5A 4G3MA 3UM5A 1U72A 3NRRA 1OHJA 3DL5A 2BLBA 4H96A 5HQZA 3FQVA 3FY9X 2W9SA 2ANOA 4QLGA 1SEJA 3KJRA 4I13A 5CCCA 1J3IA 3DL6A 3KGYA 1DDSA 3SRUX 5E8QA 2INQA 3QLRA 1VDRA 5ECXA 1D1GA 1RE7A 3FQFA 2C2SA 3DRCA 3QLXA 3FRBX 2W9HA 3FREX 4LAGX 1KLKA 3CLBA 1RF7A 3NZDA 4KJJA 3D80A 4GH8A 1RA8A 4IXGX 2W3BA 3DGAA 3SRWX 4QLEA 1M7AA 1DHFA 3NXTA 4M6KA 4IXED 3SAIA 3QYLA 1RB2A 4XT7A 3K74A 1DREA 4H98A 2ITHA 3JSUA 3RO9A 3QLWA 4ELHA 3NZCX 3QLYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4G95 A;  4P68 A;  3IRN A;  1DLS A;  2W3A A;  3GHC A;  4KNE A;  3FL8 A;  3SA1 A;  3S3V A;  3K45 A;  2LF1 A;  3OCH A;  1DYI A;  2HXV A;  1RX8 A;  1MVS A;  3DAU A;  1DIU A;  4DFR A;  1DF7 A;  1M79 A;  4XE6 X;  3NTZ A;  1CD2 A;  3GHV A;  3FL9 A;  2W9T A;  3F0B X;  5HVE A;  4KY8 A;  1HFP A;  4QI9 A;  1KMV A;  3CL9 A;  2ANQ A;  3EEK A;  4PSY A;  5EAJ A;  1RX3 A;  5HT4 A;  2P4G A;  3QYO A;  3F0S X;  3FY8 X;  3IRO A;  4KD7 A;  1E26 A;  1DR6 A;  1DRB A;  3UM6 A;  4LAH X;  2BLA A;  3K2H A;  3F91 A;  3TQB A;  4IXF X;  2BL9 A;  2HM9 A;  3N0H A;  1IA3 A;  4OSG A;  4PDJ A;  3TD8 A;  2FZI A;  4DP3 A;  3Q1H A;  1DG5 A;  1RH3 A;  3FQ0 A;  3QFX A;  4Q0D A;  4XT8 A;  3LG4 A;  4PST A;  3TQ8 A;  3TQA A;  3DG8 A;  1DR5 A;  3JTW A;  5FDA A;  2H2Q A;  1DRA A;  5CC9 A;  1DAJ A;  5HPB A;  1IA1 A;  2W3M A;  2B3Z A;  4M7U A;  3EEM A;  3FYV X;  1AOE A;  4QJC A;  3FQO A;  4ELG A;  1BZF A;  3KFY A;  1KMS A;  2O7P A;  5U26 A;  3NXV A;  4EJ1 A;  5HI6 A;  1DLR A;  4XT4 A;  4M6L A;  4QLF A;  2CD2 A;  4QHV A;  3SRR X;  1M78 A;  5HUI A;  3NZB X;  3GI2 A;  4M7V A;  1TDR A;  3EX8 A;  3NZ6 X;  3GYF A;  1LY3 A;  1DR1 A;  1BOZ A;  1RX7 A;  1RA2 A;  1S3U A;  3FRF X;  4KM2 A;  3IRM A;  1S3W A;  1DG7 A;  1PD9 A;  4KM0 A;  1QZF A;  3RG9 A;  5ECC A;  1HFR A;  3E0B A;  4FGH A;  4HA9 A;  4Q67 A;  2ZZA A;  4H97 A;  3INV A;  4EIZ A;  4G8Z X;  2OBC A;  5HT5 A;  1JOM A;  3QLZ A;  1RA9 A;  4KEB A;  1PDB A;  3SA2 A;  2W3V A;  4ELE A;  3SQY X;  4X5F A;  4P66 A;  1RX2 A;  4NX6 A;  3SGY A;  4KJK A;  3QL0 A;  4NX7 A;  5HQY A;  1HFQ A;  3CD2 A;  1ZDR A;  1CZ3 A;  3SH2 A;  3NXO A;  2C2T A;  2GD9 A;  4M6J A;  1DG8 A;  4KY4 A;  1JUV A;  3KJS A;  4PTJ A;  4P3R A;  3IA5 A;  1DYR A;  1IA2 A;  4ELF A;  3FRA X;  1VJ3 A;  3ROA A;  1DDR A;  3UM8 A;  1DHI A;  4EIL A;  2L28 A;  4FHB A;  3SR5 X;  3QGT A;  3I8A X;  4LEK X;  3GHW A;  4OR7 A;  4XRB A;  3S9U A;  3QG2 A;  2KGK A;  3I3R A;  4KAK A;  4QJZ D;  4X5H A;  1AI9 A;  3KY8 A;  3D84 X;  4Q6A A;  4CD2 A;  3M09 A;  3JW3 A;  4HOE A;  1S3Y A;  2OIP A;  4KL9 A;  1DRF A;  2FZH A;  4KYA A;  1DRH A;  1U70 A;  3F0Q X;  2DHF A;  8DFR A;  4Q0E A;  3FS6 A;  3S7A A;  5U27 A;  2W9G A;  3FYW X;  4HOG A;  5HSU A;  1RA3 A;  1RX6 A;  3EIG A;  1YHO A;  1MVT A;  3JW5 A;  3L3R A;  1RC4 A;  4X5I A;  1DR3 A;  4LAE X;  1U71 A;  1DYH A;  3QLS A;  1RX9 A;  1RG7 A;  3IA4 A;  3NXR A;  3TQ9 A;  4X5J A;  1J3J A;  4DPD A;  4P3Q A;  1DHJ A;  4XT5 A;  1DR2 A;  2D0K A;  2HQP A;  1RD7 A;  2JYB A;  5DFR A;  7DFR A;  5JG0 X;  3F0V X;  3ZPG A;  1DIS A;  3VCO A;  2D5N A;  3FQC A;  5HF2 X;  5HF0 X;  1RX4 A;  3JWF A;  3EEL A;  4DPH A;  3NXX A;  3DAT A;  3F0X X;  4M2X A;  4ECK A;  2W3W A;  1PD8 A;  3F8Y A;  3R33 A;  1RA1 A;  3FQZ A;  4HOF A;  4KLX A;  5HVB A;  1JOL A;  2G6V A;  1OHK A;  2CIG A;  3NZ9 X;  3JWC A;  3JWM A;  1DR4 A;  3ZPC A;  5HSR A;  4KBN A;  2AZN A;  3M08 A;  4XEC X;  4KJL A;  4RGC A;  3SRS X;  4XT6 A;  3IX9 A;  3QL3 A;  3CSE A;  3F0U X;  1AO8 A;  4I1N A;  4EIG A;  4FGG A;  3NXY A;  1DYJ A;  4TU5 X;  1RX1 A;  4HA7 A;  3JVX A;  1LY4 A;  3FRD X;  3NZA X;  4H95 A;  1LUD A;  4PTH A;  2XW7 A;  1IA4 A;  4X5G A;  1J3K A;  4KFJ A;  3EEJ A;  1RB3 A;  3K47 A;  2DRC A;  3HJ3 A;  3NU0 A;  3DFR A;  2QK8 A;  3F8Z A;  2FZJ A;  3OAF A;  5JA3 A;  3HBB A;  1S3V A;  3SRQ X;  5DXV A;  1DR7 A;  4DDR A;  4ELB A;  4PSS A;  2BLC A;  3JWK A;  6DFR A;  1RX5 A;  4G3M A;  3UM5 A;  1U72 A;  3NRR A;  1OHJ A;  3DL5 A;  2BLB A;  4H96 A;  5HQZ A;  3FQV A;  3FY9 X;  2W9S A;  2ANO A;  4QLG A;  1SEJ A;  3KJR A;  4I13 A;  5CCC A;  1J3I A;  3DL6 A;  3KGY A;  1DDS A;  3SRU X;  5E8Q A;  2INQ A;  3QLR A;  1VDR A;  5ECX A;  1D1G A;  1RE7 A;  3FQF A;  2C2S A;  3DRC A;  3QLX A;  3FRB X;  2W9H A;  3FRE X;  4LAG X;  1KLK A;  3CLB A;  1RF7 A;  3NZD A;  4KJJ A;  3D80 A;  4GH8 A;  1RA8 A;  4IXG X;  2W3B A;  3DGA A;  3SRW X;  4QLE A;  1M7A A;  1DHF A;  3NXT A;  4M6K A;  4IXE D;  3SAI A;  3QYL A;  1RB2 A;  4XT7 A;  3K74 A;  1DRE A;  4H98 A;  2ITH A;  3JSU A;  3RO9 A;  3QLW A;  4ELH A;  3NZC X;  3QLY A; 
#chains in the Genus database with same CATH topology
 4G95 A;  4P68 A;  3IRN A;  1DLS A;  2W3A A;  3GHC A;  4KNE A;  3FL8 A;  3SA1 A;  3S3V A;  3K45 A;  2LF1 A;  3OCH A;  1DYI A;  2HXV A;  1RX8 A;  1MVS A;  3DAU A;  1DIU A;  4DFR A;  1DF7 A;  1M79 A;  4XE6 X;  3NTZ A;  1CD2 A;  3GHV A;  3FL9 A;  2W9T A;  3F0B X;  5HVE A;  4KY8 A;  1HFP A;  4QI9 A;  1KMV A;  3CL9 A;  2ANQ A;  3EEK A;  4PSY A;  5EAJ A;  1RX3 A;  5HT4 A;  2P4G A;  3QYO A;  3F0S X;  3FY8 X;  3IRO A;  4KD7 A;  1E26 A;  1DR6 A;  1DRB A;  3UM6 A;  4LAH X;  2BLA A;  3K2H A;  3F91 A;  3TQB A;  4IXF X;  2BL9 A;  2HM9 A;  3N0H A;  1IA3 A;  4OSG A;  4PDJ A;  3TD8 A;  2FZI A;  4DP3 A;  3Q1H A;  1DG5 A;  1RH3 A;  3FQ0 A;  3QFX A;  4Q0D A;  4XT8 A;  3LG4 A;  4PST A;  3TQ8 A;  3TQA A;  3DG8 A;  1DR5 A;  3JTW A;  5FDA A;  2H2Q A;  1DRA A;  5CC9 A;  1DAJ A;  5HPB A;  1IA1 A;  2W3M A;  2B3Z A;  4M7U A;  3EEM A;  3FYV X;  1AOE A;  4QJC A;  3FQO A;  4ELG A;  1BZF A;  3KFY A;  1KMS A;  2O7P A;  5U26 A;  3NXV A;  4EJ1 A;  5HI6 A;  1DLR A;  4XT4 A;  4M6L A;  4QLF A;  2CD2 A;  4QHV A;  3SRR X;  1M78 A;  5HUI A;  3NZB X;  3GI2 A;  4M7V A;  1TDR A;  3EX8 A;  3NZ6 X;  3GYF A;  1LY3 A;  1DR1 A;  1BOZ A;  1RX7 A;  1RA2 A;  1S3U A;  3FRF X;  4KM2 A;  3IRM A;  1S3W A;  1DG7 A;  1PD9 A;  4KM0 A;  1QZF A;  3RG9 A;  5ECC A;  1HFR A;  3E0B A;  4FGH A;  4HA9 A;  4Q67 A;  2ZZA A;  4H97 A;  3INV A;  4EIZ A;  4G8Z X;  2OBC A;  5HT5 A;  1JOM A;  3QLZ A;  1RA9 A;  4KEB A;  1PDB A;  3SA2 A;  2W3V A;  4ELE A;  3SQY X;  4X5F A;  4P66 A;  1RX2 A;  4NX6 A;  3SGY A;  4KJK A;  3QL0 A;  4NX7 A;  5HQY A;  1HFQ A;  3CD2 A;  1ZDR A;  1CZ3 A;  3SH2 A;  3NXO A;  2C2T A;  2GD9 A;  4M6J A;  1DG8 A;  4KY4 A;  1JUV A;  3KJS A;  4PTJ A;  4P3R A;  3IA5 A;  1DYR A;  1IA2 A;  4ELF A;  3FRA X;  1VJ3 A;  3ROA A;  1DDR A;  3UM8 A;  1DHI A;  4EIL A;  2L28 A;  4FHB A;  3SR5 X;  3QGT A;  3I8A X;  4LEK X;  3GHW A;  4OR7 A;  4XRB A;  3S9U A;  3QG2 A;  2KGK A;  3I3R A;  4KAK A;  4QJZ D;  4X5H A;  1AI9 A;  3KY8 A;  3D84 X;  4Q6A A;  4CD2 A;  3M09 A;  3JW3 A;  4HOE A;  1S3Y A;  2OIP A;  4KL9 A;  1DRF A;  2FZH A;  4KYA A;  1DRH A;  1U70 A;  3F0Q X;  2DHF A;  8DFR A;  4Q0E A;  3FS6 A;  3S7A A;  5U27 A;  2W9G A;  3FYW X;  4HOG A;  5HSU A;  1RA3 A;  1RX6 A;  3EIG A;  1YHO A;  1MVT A;  3JW5 A;  3L3R A;  1RC4 A;  4X5I A;  1DR3 A;  4LAE X;  1U71 A;  1DYH A;  3QLS A;  1RX9 A;  1RG7 A;  3IA4 A;  3NXR A;  3TQ9 A;  4X5J A;  1J3J A;  4DPD A;  4P3Q A;  1DHJ A;  4XT5 A;  1DR2 A;  2D0K A;  2HQP A;  1RD7 A;  2JYB A;  5DFR A;  7DFR A;  5JG0 X;  3F0V X;  3ZPG A;  1DIS A;  3VCO A;  2D5N A;  3FQC A;  5HF2 X;  5HF0 X;  1RX4 A;  3JWF A;  3EEL A;  4DPH A;  3NXX A;  3DAT A;  3F0X X;  4M2X A;  4ECK A;  2W3W A;  1PD8 A;  3F8Y A;  3R33 A;  1RA1 A;  3FQZ A;  4HOF A;  4KLX A;  5HVB A;  1JOL A;  2G6V A;  1OHK A;  2CIG A;  3NZ9 X;  3JWC A;  3JWM A;  1DR4 A;  3ZPC A;  5HSR A;  4KBN A;  2AZN A;  3M08 A;  4XEC X;  4KJL A;  4RGC A;  3SRS X;  4XT6 A;  3IX9 A;  3QL3 A;  3CSE A;  3F0U X;  1AO8 A;  4I1N A;  4EIG A;  4FGG A;  3NXY A;  1DYJ A;  4TU5 X;  1RX1 A;  4HA7 A;  3JVX A;  1LY4 A;  3FRD X;  3NZA X;  4H95 A;  1LUD A;  4PTH A;  2XW7 A;  1IA4 A;  4X5G A;  1J3K A;  4KFJ A;  3EEJ A;  1RB3 A;  3K47 A;  2DRC A;  3HJ3 A;  3NU0 A;  3DFR A;  2QK8 A;  3F8Z A;  2FZJ A;  3OAF A;  5JA3 A;  3HBB A;  1S3V A;  3SRQ X;  5DXV A;  1DR7 A;  4DDR A;  4ELB A;  4PSS A;  2BLC A;  3JWK A;  6DFR A;  1RX5 A;  4G3M A;  3UM5 A;  1U72 A;  3NRR A;  1OHJ A;  3DL5 A;  2BLB A;  4H96 A;  5HQZ A;  3FQV A;  3FY9 X;  2W9S A;  2ANO A;  4QLG A;  1SEJ A;  3KJR A;  4I13 A;  5CCC A;  1J3I A;  3DL6 A;  3KGY A;  1DDS A;  3SRU X;  5E8Q A;  2INQ A;  3QLR A;  1VDR A;  5ECX A;  1D1G A;  1RE7 A;  3FQF A;  2C2S A;  3DRC A;  3QLX A;  3FRB X;  2W9H A;  3FRE X;  4LAG X;  1KLK A;  3CLB A;  1RF7 A;  3NZD A;  4KJJ A;  3D80 A;  4GH8 A;  1RA8 A;  4IXG X;  2W3B A;  3DGA A;  3SRW X;  4QLE A;  1M7A A;  1DHF A;  3NXT A;  4M6K A;  4IXE D;  3SAI A;  3QYL A;  1RB2 A;  4XT7 A;  3K74 A;  1DRE A;  4H98 A;  2ITH A;  3JSU A;  3RO9 A;  3QLW A;  4ELH A;  3NZC X;  3QLY A; 
#chains in the Genus database with same CATH homology
 4G95 A;  4P68 A;  3IRN A;  1DLS A;  2W3A A;  3GHC A;  4KNE A;  3FL8 A;  3SA1 A;  3S3V A;  3K45 A;  2LF1 A;  3OCH A;  1DYI A;  2HXV A;  1RX8 A;  1MVS A;  3DAU A;  1DIU A;  4DFR A;  1DF7 A;  1M79 A;  4XE6 X;  3NTZ A;  1CD2 A;  3GHV A;  3FL9 A;  2W9T A;  3F0B X;  5HVE A;  4KY8 A;  1HFP A;  4QI9 A;  1KMV A;  3CL9 A;  2ANQ A;  3EEK A;  4PSY A;  5EAJ A;  1RX3 A;  5HT4 A;  2P4G A;  3QYO A;  3F0S X;  3FY8 X;  3IRO A;  4KD7 A;  1E26 A;  1DR6 A;  1DRB A;  3UM6 A;  4LAH X;  2BLA A;  3K2H A;  3F91 A;  3TQB A;  4IXF X;  2BL9 A;  2HM9 A;  3N0H A;  1IA3 A;  4OSG A;  4PDJ A;  3TD8 A;  2FZI A;  4DP3 A;  3Q1H A;  1DG5 A;  1RH3 A;  3FQ0 A;  3QFX A;  4Q0D A;  4XT8 A;  3LG4 A;  4PST A;  3TQ8 A;  3TQA A;  3DG8 A;  1DR5 A;  3JTW A;  5FDA A;  2H2Q A;  1DRA A;  5CC9 A;  1DAJ A;  5HPB A;  1IA1 A;  2W3M A;  2B3Z A;  4M7U A;  3EEM A;  3FYV X;  1AOE A;  4QJC A;  3FQO A;  4ELG A;  1BZF A;  3KFY A;  1KMS A;  2O7P A;  5U26 A;  3NXV A;  4EJ1 A;  5HI6 A;  1DLR A;  4XT4 A;  4M6L A;  4QLF A;  2CD2 A;  4QHV A;  3SRR X;  1M78 A;  5HUI A;  3NZB X;  3GI2 A;  4M7V A;  1TDR A;  3EX8 A;  3NZ6 X;  3GYF A;  1LY3 A;  1DR1 A;  1BOZ A;  1RX7 A;  1RA2 A;  1S3U A;  3FRF X;  4KM2 A;  3IRM A;  1S3W A;  1DG7 A;  1PD9 A;  4KM0 A;  1QZF A;  3RG9 A;  5ECC A;  1HFR A;  3E0B A;  4FGH A;  4HA9 A;  4Q67 A;  2ZZA A;  4H97 A;  3INV A;  4EIZ A;  4G8Z X;  2OBC A;  5HT5 A;  1JOM A;  3QLZ A;  1RA9 A;  4KEB A;  1PDB A;  3SA2 A;  2W3V A;  4ELE A;  3SQY X;  4X5F A;  4P66 A;  1RX2 A;  4NX6 A;  3SGY A;  4KJK A;  3QL0 A;  4NX7 A;  5HQY A;  1HFQ A;  3CD2 A;  1ZDR A;  1CZ3 A;  3SH2 A;  3NXO A;  2C2T A;  2GD9 A;  4M6J A;  1DG8 A;  4KY4 A;  1JUV A;  3KJS A;  4PTJ A;  4P3R A;  3IA5 A;  1DYR A;  1IA2 A;  4ELF A;  3FRA X;  1VJ3 A;  3ROA A;  1DDR A;  3UM8 A;  1DHI A;  4EIL A;  2L28 A;  4FHB A;  3SR5 X;  3QGT A;  3I8A X;  4LEK X;  3GHW A;  4OR7 A;  4XRB A;  3S9U A;  3QG2 A;  2KGK A;  3I3R A;  4KAK A;  4QJZ D;  4X5H A;  1AI9 A;  3KY8 A;  3D84 X;  4Q6A A;  4CD2 A;  3M09 A;  3JW3 A;  4HOE A;  1S3Y A;  2OIP A;  4KL9 A;  1DRF A;  2FZH A;  4KYA A;  1DRH A;  1U70 A;  3F0Q X;  2DHF A;  8DFR A;  4Q0E A;  3FS6 A;  3S7A A;  5U27 A;  2W9G A;  3FYW X;  4HOG A;  5HSU A;  1RA3 A;  1RX6 A;  3EIG A;  1YHO A;  1MVT A;  3JW5 A;  3L3R A;  1RC4 A;  4X5I A;  1DR3 A;  4LAE X;  1U71 A;  1DYH A;  3QLS A;  1RX9 A;  1RG7 A;  3IA4 A;  3NXR A;  3TQ9 A;  4X5J A;  1J3J A;  4DPD A;  4P3Q A;  1DHJ A;  4XT5 A;  1DR2 A;  2D0K A;  2HQP A;  1RD7 A;  2JYB A;  5DFR A;  7DFR A;  5JG0 X;  3F0V X;  3ZPG A;  1DIS A;  3VCO A;  2D5N A;  3FQC A;  5HF2 X;  5HF0 X;  1RX4 A;  3JWF A;  3EEL A;  4DPH A;  3NXX A;  3DAT A;  3F0X X;  4M2X A;  4ECK A;  2W3W A;  1PD8 A;  3F8Y A;  3R33 A;  1RA1 A;  3FQZ A;  4HOF A;  4KLX A;  5HVB A;  1JOL A;  2G6V A;  1OHK A;  2CIG A;  3NZ9 X;  3JWC A;  3JWM A;  1DR4 A;  3ZPC A;  5HSR A;  4KBN A;  2AZN A;  3M08 A;  4XEC X;  4KJL A;  4RGC A;  3SRS X;  4XT6 A;  3IX9 A;  3QL3 A;  3CSE A;  3F0U X;  1AO8 A;  4I1N A;  4EIG A;  4FGG A;  3NXY A;  1DYJ A;  4TU5 X;  1RX1 A;  4HA7 A;  3JVX A;  1LY4 A;  3FRD X;  3NZA X;  4H95 A;  1LUD A;  4PTH A;  2XW7 A;  1IA4 A;  4X5G A;  1J3K A;  4KFJ A;  3EEJ A;  1RB3 A;  3K47 A;  2DRC A;  3HJ3 A;  3NU0 A;  3DFR A;  2QK8 A;  3F8Z A;  2FZJ A;  3OAF A;  5JA3 A;  3HBB A;  1S3V A;  3SRQ X;  5DXV A;  1DR7 A;  4DDR A;  4ELB A;  4PSS A;  2BLC A;  3JWK A;  6DFR A;  1RX5 A;  4G3M A;  3UM5 A;  1U72 A;  3NRR A;  1OHJ A;  3DL5 A;  2BLB A;  4H96 A;  5HQZ A;  3FQV A;  3FY9 X;  2W9S A;  2ANO A;  4QLG A;  1SEJ A;  3KJR A;  4I13 A;  5CCC A;  1J3I A;  3DL6 A;  3KGY A;  1DDS A;  3SRU X;  5E8Q A;  2INQ A;  3QLR A;  1VDR A;  5ECX A;  1D1G A;  1RE7 A;  3FQF A;  2C2S A;  3DRC A;  3QLX A;  3FRB X;  2W9H A;  3FRE X;  4LAG X;  1KLK A;  3CLB A;  1RF7 A;  3NZD A;  4KJJ A;  3D80 A;  4GH8 A;  1RA8 A;  4IXG X;  2W3B A;  3DGA A;  3SRW X;  4QLE A;  1M7A A;  1DHF A;  3NXT A;  4M6K A;  4IXE D;  3SAI A;  3QYL A;  1RB2 A;  4XT7 A;  3K74 A;  1DRE A;  4H98 A;  2ITH A;  3JSU A;  3RO9 A;  3QLW A;  4ELH A;  3NZC X;  3QLY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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