5HSUA

Fluorine substituted 5-methyl-6-(2',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine
Total Genus 56
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
56
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines
rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 56
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-01-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5hsuA00
5E8QA 3NXOA 1MVTA 1S3YA 2P4GA 3NRRA 3QYLA 1RA2A 4ELHA 3UM8A 4P3QA 1JOMA 2L28A 4M2XA 4X5FA 1RX3A 4X5HA 3INVA 3EEMA 1DLSA 4QI9A 4QLEA 3TQBA 1RG7A 1DAJA 1QZFA 4XECX 3JWCA 3CL9A 2C2TA 4Q6AA 4KYAA 3E0BA 1S3VA 3F0SX 3NTZA 1HFRA 1DR4A 5ECXA 3SRWX 3D84X 4DFRA 3GHCA 1RB2A 3QGTA 3IRMA 1E26A 1DLRA 3SRQX 3NZAX 1DR3A 2ANOA 2D0KA 3FQZA 1DYRA 3RO9A 1DYHA 3DFRA 2INQA 4LAHX 3FY8X 3FRAX 4DP3A 3QLXA 3QYOA 4NX6A 3IA5A 1BZFA 3KJSA 1DR5A 4FGGA 4H97A 3FQFA 1J3JA 3FQCA 4HA7A 1M79A 1CZ3A 2CD2A 4PSYA 1DRHA 3JW3A 2W3VA 1KMSA 4X5IA 3KJRA 1AOEA 1JOLA 1DHJA 2HM9A 2JYBA 3SGYA 3FQVA 4M6KA 3EELA 1RX6A 4OR7A 4RGCA 1M78A 1DYJA 4KJKA 4XRBA 2BL9A 1DDRA 1DHIA 1RA3A 3TQAA 5HF0X 2FZIA 4KLXA 5HF2X 3FYVX 1DR2A 3Q1HA 4KM0A 1IA1A 4G8ZX 4ELEA 1RA1A 3JWFA 1PD9A 5HPBA 2BLCA 3OCHA 3QL3A 4PSTA 2G6VA 1RX1A 2ANQA 3N0HA 4M6LA 3SAIA 3QFXA 1KMVA 5JA3A 1VJ3A 3NXRA 3FL9A 2B3ZA 1CD2A 2W9SA 3NXVA 4G95A 5HT5A 3NZDA 4XT8A 3SA2A 4ELFA 4Q0EA 3DL6A 1AO8A 4QLGA 5HT4A 3F0XX 3F8YA 2HQPA 2W3BA 2W9GA 1DHFA 5U27A 4EIZA 3S9UA 3FRBX 3SRSX 3M09A 4KY8A 1RH3A 1RB3A 1RX5A 3M08A 2AZNA 3TD8A 4M6JA 1J3IA 4DPHA 3JTWA 1U72A 4DDRA 3DATA 1KLKA 1HFPA 1OHJA 4KY4A 4HOGA 3DGAA 4QHVA 1DR6A 1DG7A 4XT5A 4HOEA 3JW5A 1AI9A 3QG2A 3EEJA 4X5JA 3F8ZA 1HFQA 2BLBA 1RF7A 1DF7A 3SH2A 3FL8A 3SQYX 3ROAA 4XT7A 4XT4A 4KAKA 5CC9A 2D5NA 3SR5X 2CIGA 3CSEA 4ELBA 4KJJA 3ZPGA 4NX7A 4X5GA 1VDRA 1ZDRA 3SRRX 4PDJA 3DRCA 4H96A 3NXYA 3CD2A 3GHVA 3QLZA 1RX8A 2C2SA 4Q0DA 1RC4A 3SRUX 5DXVA 1IA4A 4FHBA 3I3RA 3LG4A 4LEKX 2W9TA 4I13A 4M7VA 3FY9X 1M7AA 3GHWA 4GH8A 1DRFA 5ECCA 4Q67A 3DL5A 2GD9A 4OSGA 5HQZA 3EX8A 3CLBA 3QL0A 4XE6X 1DR1A 1RX7A 2ZZAA 4QJZD 3R33A 4M7UA 1DREA 1PD8A 4CD2A 3KY8A 4KEBA 4EILA 4IXFX 3HBBA 3JWMA 5DFRA 1U71A 5JG0X 3GI2A 3K2HA 4EJ1A 4KFJA 3EIGA 3FRFX 1LY3A 3FREX 4H95A 4HOFA 5HVEA 3SA1A 5FDAA 1DISA 1D1GA 3F0QX 2W3AA 4G3MA 1OHKA 1PDBA 3DAUA 4KJLA 3JVXA 4LAEX 3NXTA 3ZPCA 5CCCA 3NZBX 4ECKA 3QLSA 1DR7A 3FS6A 1S3UA 3UM6A 4P68A 3NZ9X 3TQ8A 3QLYA 2H2QA 1DRAA 2O7PA 4P3RA 3S7AA 4EIGA 1IA3A 1IA2A 3JSUA 1DIUA 3F0BX 4DPDA 2W9HA 1MVSA 1RD7A 2OBCA 2ITHA 4KL9A 5HSUA 3EEKA 7DFRA 3DG8A 3F91A 4IXED 3FYWX 8DFRA 4PTJA 1JUVA 2QK8A 3NXXA 3L3RA 3UM5A 2DRCA 1RE7A 1S3WA 4LAGX 3F0UX 2BLAA 4PSSA 3GYFA 3F0VX 5HUIA 4I1NA 2W3WA 1DG5A 1DG8A 3IX9A 1YHOA 2FZHA 5U26A 5HVBA 2LF1A 3IROA 2OIPA 3IRNA 3VCOA 4ELGA 1LY4A 3JWKA 4KNEA 4KBNA 3TQ9A 4KD7A 3KGYA 4HA9A 4QLFA 3S3VA 1LUDA 2DHFA 2FZJA 4PTHA 3OAFA 3K45A 4XT6A 4P66A 1J3KA 1DDSA 6DFRA 5HSRA 3HJ3A 3D80A 3IA4A 4H98A 3KFYA 2KGKA 1RX2A 3NU0A 1U70A 4FGHA 4TU5X 2XW7A 5EAJA 3FRDX 1RA8A 1RX9A 3NZCX 4IXGX 3I8AX 5HI6A 3FQ0A 3QLRA 4KM2A 3RG9A 3K47A 4QJCA 2HXVA 1DRBA 3K74A 1BOZA 3NZ6X 5HQYA 3QLWA 2W3MA 1RA9A 1DYIA 3FQOA 1SEJA 1RX4A 1TDRA
chains in the Genus database with same CATH superfamily
5E8QA 3NXOA 1MVTA 1S3YA 2P4GA 3NRRA 3QYLA 1RA2A 4ELHA 3UM8A 4P3QA 1JOMA 2L28A 4M2XA 4X5FA 1RX3A 4X5HA 3INVA 3EEMA 1DLSA 4QI9A 4QLEA 3TQBA 1RG7A 1DAJA 1QZFA 4XECX 3JWCA 3CL9A 2C2TA 4Q6AA 4KYAA 3E0BA 1S3VA 3F0SX 3NTZA 1HFRA 1DR4A 5ECXA 3SRWX 3D84X 4DFRA 3GHCA 1RB2A 3QGTA 3IRMA 1E26A 1DLRA 3SRQX 3NZAX 1DR3A 2ANOA 2D0KA 3FQZA 1DYRA 3RO9A 1DYHA 3DFRA 2INQA 4LAHX 3FY8X 3FRAX 4DP3A 3QLXA 3QYOA 4NX6A 3IA5A 1BZFA 3KJSA 1DR5A 4FGGA 4H97A 3FQFA 1J3JA 3FQCA 4HA7A 1M79A 1CZ3A 2CD2A 4PSYA 1DRHA 3JW3A 2W3VA 1KMSA 4X5IA 3KJRA 1AOEA 1JOLA 1DHJA 2HM9A 2JYBA 3SGYA 3FQVA 4M6KA 3EELA 1RX6A 4OR7A 4RGCA 1M78A 1DYJA 4KJKA 4XRBA 2BL9A 1DDRA 1DHIA 1RA3A 3TQAA 5HF0X 2FZIA 4KLXA 5HF2X 3FYVX 1DR2A 3Q1HA 4KM0A 1IA1A 4G8ZX 4ELEA 1RA1A 3JWFA 1PD9A 5HPBA 2BLCA 3OCHA 3QL3A 4PSTA 2G6VA 1RX1A 2ANQA 3N0HA 4M6LA 3SAIA 3QFXA 1KMVA 5JA3A 1VJ3A 3NXRA 3FL9A 2B3ZA 1CD2A 2W9SA 3NXVA 4G95A 5HT5A 3NZDA 4XT8A 3SA2A 4ELFA 4Q0EA 3DL6A 1AO8A 4QLGA 5HT4A 3F0XX 3F8YA 2HQPA 2W3BA 2W9GA 1DHFA 5U27A 4EIZA 3S9UA 3FRBX 3SRSX 3M09A 4KY8A 1RH3A 1RB3A 1RX5A 3M08A 2AZNA 3TD8A 4M6JA 1J3IA 4DPHA 3JTWA 1U72A 4DDRA 3DATA 1KLKA 1HFPA 1OHJA 4KY4A 4HOGA 3DGAA 4QHVA 1DR6A 1DG7A 4XT5A 4HOEA 3JW5A 1AI9A 3QG2A 3EEJA 4X5JA 3F8ZA 1HFQA 2BLBA 1RF7A 1DF7A 3SH2A 3FL8A 3SQYX 3ROAA 4XT7A 4XT4A 4KAKA 5CC9A 2D5NA 3SR5X 2CIGA 3CSEA 4ELBA 4KJJA 3ZPGA 4NX7A 4X5GA 1VDRA 1ZDRA 3SRRX 4PDJA 3DRCA 4H96A 3NXYA 3CD2A 3GHVA 3QLZA 1RX8A 2C2SA 4Q0DA 1RC4A 3SRUX 5DXVA 1IA4A 4FHBA 3I3RA 3LG4A 4LEKX 2W9TA 4I13A 4M7VA 3FY9X 1M7AA 3GHWA 4GH8A 1DRFA 5ECCA 4Q67A 3DL5A 2GD9A 4OSGA 5HQZA 3EX8A 3CLBA 3QL0A 4XE6X 1DR1A 1RX7A 2ZZAA 4QJZD 3R33A 4M7UA 1DREA 1PD8A 4CD2A 3KY8A 4KEBA 4EILA 4IXFX 3HBBA 3JWMA 5DFRA 1U71A 5JG0X 3GI2A 3K2HA 4EJ1A 4KFJA 3EIGA 3FRFX 1LY3A 3FREX 4H95A 4HOFA 5HVEA 3SA1A 5FDAA 1DISA 1D1GA 3F0QX 2W3AA 4G3MA 1OHKA 1PDBA 3DAUA 4KJLA 3JVXA 4LAEX 3NXTA 3ZPCA 5CCCA 3NZBX 4ECKA 3QLSA 1DR7A 3FS6A 1S3UA 3UM6A 4P68A 3NZ9X 3TQ8A 3QLYA 2H2QA 1DRAA 2O7PA 4P3RA 3S7AA 4EIGA 1IA3A 1IA2A 3JSUA 1DIUA 3F0BX 4DPDA 2W9HA 1MVSA 1RD7A 2OBCA 2ITHA 4KL9A 5HSUA 3EEKA 7DFRA 3DG8A 3F91A 4IXED 3FYWX 8DFRA 4PTJA 1JUVA 2QK8A 3NXXA 3L3RA 3UM5A 2DRCA 1RE7A 1S3WA 4LAGX 3F0UX 2BLAA 4PSSA 3GYFA 3F0VX 5HUIA 4I1NA 2W3WA 1DG5A 1DG8A 3IX9A 1YHOA 2FZHA 5U26A 5HVBA 2LF1A 3IROA 2OIPA 3IRNA 3VCOA 4ELGA 1LY4A 3JWKA 4KNEA 4KBNA 3TQ9A 4KD7A 3KGYA 4HA9A 4QLFA 3S3VA 1LUDA 2DHFA 2FZJA 4PTHA 3OAFA 3K45A 4XT6A 4P66A 1J3KA 1DDSA 6DFRA 5HSRA 3HJ3A 3D80A 3IA4A 4H98A 3KFYA 2KGKA 1RX2A 3NU0A 1U70A 4FGHA 4TU5X 2XW7A 5EAJA 3FRDX 1RA8A 1RX9A 3NZCX 4IXGX 3I8AX 5HI6A 3FQ0A 3QLRA 4KM2A 3RG9A 3K47A 4QJCA 2HXVA 1DRBA 3K74A 1BOZA 3NZ6X 5HQYA 3QLWA 2W3MA 1RA9A 1DYIA 3FQOA 1SEJA 1RX4A 1TDRA
chains in the Genus database with same CATH topology
5E8QA 3NXOA 1MVTA 1S3YA 2P4GA 3NRRA 3QYLA 1RA2A 4ELHA 3UM8A 4P3QA 1JOMA 2L28A 4M2XA 4X5FA 1RX3A 4X5HA 3INVA 3EEMA 1DLSA 4QI9A 4QLEA 3TQBA 1RG7A 1DAJA 1QZFA 4XECX 3JWCA 3CL9A 2C2TA 4Q6AA 4KYAA 3E0BA 1S3VA 3F0SX 3NTZA 1HFRA 1DR4A 5ECXA 3SRWX 3D84X 4DFRA 3GHCA 1RB2A 3QGTA 3IRMA 1E26A 1DLRA 3SRQX 3NZAX 1DR3A 2ANOA 2D0KA 3FQZA 1DYRA 3RO9A 1DYHA 3DFRA 2INQA 4LAHX 3FY8X 3FRAX 4DP3A 3QLXA 3QYOA 4NX6A 3IA5A 1BZFA 3KJSA 1DR5A 4FGGA 4H97A 3FQFA 1J3JA 3FQCA 4HA7A 1M79A 1CZ3A 2CD2A 4PSYA 1DRHA 3JW3A 2W3VA 1KMSA 4X5IA 3KJRA 1AOEA 1JOLA 1DHJA 2HM9A 2JYBA 3SGYA 3FQVA 4M6KA 3EELA 1RX6A 4OR7A 4RGCA 1M78A 1DYJA 4KJKA 4XRBA 2BL9A 1DDRA 1DHIA 1RA3A 3TQAA 5HF0X 2FZIA 4KLXA 5HF2X 3FYVX 1DR2A 3Q1HA 4KM0A 1IA1A 4G8ZX 4ELEA 1RA1A 3JWFA 1PD9A 5HPBA 2BLCA 3OCHA 3QL3A 4PSTA 2G6VA 1RX1A 2ANQA 3N0HA 4M6LA 3SAIA 3QFXA 1KMVA 5JA3A 1VJ3A 3NXRA 3FL9A 2B3ZA 1CD2A 2W9SA 3NXVA 4G95A 5HT5A 3NZDA 4XT8A 3SA2A 4ELFA 4Q0EA 3DL6A 1AO8A 4QLGA 5HT4A 3F0XX 3F8YA 2HQPA 2W3BA 2W9GA 1DHFA 5U27A 4EIZA 3S9UA 3FRBX 3SRSX 3M09A 4KY8A 1RH3A 1RB3A 1RX5A 3M08A 2AZNA 3TD8A 4M6JA 1J3IA 4DPHA 3JTWA 1U72A 4DDRA 3DATA 1KLKA 1HFPA 1OHJA 4KY4A 4HOGA 3DGAA 4QHVA 1DR6A 1DG7A 4XT5A 4HOEA 3JW5A 1AI9A 3QG2A 3EEJA 4X5JA 3F8ZA 1HFQA 2BLBA 1RF7A 1DF7A 3SH2A 3FL8A 3SQYX 3ROAA 4XT7A 4XT4A 4KAKA 5CC9A 2D5NA 3SR5X 2CIGA 3CSEA 4ELBA 4KJJA 3ZPGA 4NX7A 4X5GA 1VDRA 1ZDRA 3SRRX 4PDJA 3DRCA 4H96A 3NXYA 3CD2A 3GHVA 3QLZA 1RX8A 2C2SA 4Q0DA 1RC4A 3SRUX 5DXVA 1IA4A 4FHBA 3I3RA 3LG4A 4LEKX 2W9TA 4I13A 4M7VA 3FY9X 1M7AA 3GHWA 4GH8A 1DRFA 5ECCA 4Q67A 3DL5A 2GD9A 4OSGA 5HQZA 3EX8A 3CLBA 3QL0A 4XE6X 1DR1A 1RX7A 2ZZAA 4QJZD 3R33A 4M7UA 1DREA 1PD8A 4CD2A 3KY8A 4KEBA 4EILA 4IXFX 3HBBA 3JWMA 5DFRA 1U71A 5JG0X 3GI2A 3K2HA 4EJ1A 4KFJA 3EIGA 3FRFX 1LY3A 3FREX 4H95A 4HOFA 5HVEA 3SA1A 5FDAA 1DISA 1D1GA 3F0QX 2W3AA 4G3MA 1OHKA 1PDBA 3DAUA 4KJLA 3JVXA 4LAEX 3NXTA 3ZPCA 5CCCA 3NZBX 4ECKA 3QLSA 1DR7A 3FS6A 1S3UA 3UM6A 4P68A 3NZ9X 3TQ8A 3QLYA 2H2QA 1DRAA 2O7PA 4P3RA 3S7AA 4EIGA 1IA3A 1IA2A 3JSUA 1DIUA 3F0BX 4DPDA 2W9HA 1MVSA 1RD7A 2OBCA 2ITHA 4KL9A 5HSUA 3EEKA 7DFRA 3DG8A 3F91A 4IXED 3FYWX 8DFRA 4PTJA 1JUVA 2QK8A 3NXXA 3L3RA 3UM5A 2DRCA 1RE7A 1S3WA 4LAGX 3F0UX 2BLAA 4PSSA 3GYFA 3F0VX 5HUIA 4I1NA 2W3WA 1DG5A 1DG8A 3IX9A 1YHOA 2FZHA 5U26A 5HVBA 2LF1A 3IROA 2OIPA 3IRNA 3VCOA 4ELGA 1LY4A 3JWKA 4KNEA 4KBNA 3TQ9A 4KD7A 3KGYA 4HA9A 4QLFA 3S3VA 1LUDA 2DHFA 2FZJA 4PTHA 3OAFA 3K45A 4XT6A 4P66A 1J3KA 1DDSA 6DFRA 5HSRA 3HJ3A 3D80A 3IA4A 4H98A 3KFYA 2KGKA 1RX2A 3NU0A 1U70A 4FGHA 4TU5X 2XW7A 5EAJA 3FRDX 1RA8A 1RX9A 3NZCX 4IXGX 3I8AX 5HI6A 3FQ0A 3QLRA 4KM2A 3RG9A 3K47A 4QJCA 2HXVA 1DRBA 3K74A 1BOZA 3NZ6X 5HQYA 3QLWA 2W3MA 1RA9A 1DYIA 3FQOA 1SEJA 1RX4A 1TDRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5E8Q A;  3NXO A;  1MVT A;  1S3Y A;  2P4G A;  3NRR A;  3QYL A;  1RA2 A;  4ELH A;  3UM8 A;  4P3Q A;  1JOM A;  2L28 A;  4M2X A;  4X5F A;  1RX3 A;  4X5H A;  3INV A;  3EEM A;  1DLS A;  4QI9 A;  4QLE A;  3TQB A;  1RG7 A;  1DAJ A;  1QZF A;  4XEC X;  3JWC A;  3CL9 A;  2C2T A;  4Q6A A;  4KYA A;  3E0B A;  1S3V A;  3F0S X;  3NTZ A;  1HFR A;  1DR4 A;  5ECX A;  3SRW X;  3D84 X;  4DFR A;  3GHC A;  1RB2 A;  3QGT A;  3IRM A;  1E26 A;  1DLR A;  3SRQ X;  3NZA X;  1DR3 A;  2ANO A;  2D0K A;  3FQZ A;  1DYR A;  3RO9 A;  1DYH A;  3DFR A;  2INQ A;  4LAH X;  3FY8 X;  3FRA X;  4DP3 A;  3QLX A;  3QYO A;  4NX6 A;  3IA5 A;  1BZF A;  3KJS A;  1DR5 A;  4FGG A;  4H97 A;  3FQF A;  1J3J A;  3FQC A;  4HA7 A;  1M79 A;  1CZ3 A;  2CD2 A;  4PSY A;  1DRH A;  3JW3 A;  2W3V A;  1KMS A;  4X5I A;  3KJR A;  1AOE A;  1JOL A;  1DHJ A;  2HM9 A;  2JYB A;  3SGY A;  3FQV A;  4M6K A;  3EEL A;  1RX6 A;  4OR7 A;  4RGC A;  1M78 A;  1DYJ A;  4KJK A;  4XRB A;  2BL9 A;  1DDR A;  1DHI A;  1RA3 A;  3TQA A;  5HF0 X;  2FZI A;  4KLX A;  5HF2 X;  3FYV X;  1DR2 A;  3Q1H A;  4KM0 A;  1IA1 A;  4G8Z X;  4ELE A;  1RA1 A;  3JWF A;  1PD9 A;  5HPB A;  2BLC A;  3OCH A;  3QL3 A;  4PST A;  2G6V A;  1RX1 A;  2ANQ A;  3N0H A;  4M6L A;  3SAI A;  3QFX A;  1KMV A;  5JA3 A;  1VJ3 A;  3NXR A;  3FL9 A;  2B3Z A;  1CD2 A;  2W9S A;  3NXV A;  4G95 A;  5HT5 A;  3NZD A;  4XT8 A;  3SA2 A;  4ELF A;  4Q0E A;  3DL6 A;  1AO8 A;  4QLG A;  5HT4 A;  3F0X X;  3F8Y A;  2HQP A;  2W3B A;  2W9G A;  1DHF A;  5U27 A;  4EIZ A;  3S9U A;  3FRB X;  3SRS X;  3M09 A;  4KY8 A;  1RH3 A;  1RB3 A;  1RX5 A;  3M08 A;  2AZN A;  3TD8 A;  4M6J A;  1J3I A;  4DPH A;  3JTW A;  1U72 A;  4DDR A;  3DAT A;  1KLK A;  1HFP A;  1OHJ A;  4KY4 A;  4HOG A;  3DGA A;  4QHV A;  1DR6 A;  1DG7 A;  4XT5 A;  4HOE A;  3JW5 A;  1AI9 A;  3QG2 A;  3EEJ A;  4X5J A;  3F8Z A;  1HFQ A;  2BLB A;  1RF7 A;  1DF7 A;  3SH2 A;  3FL8 A;  3SQY X;  3ROA A;  4XT7 A;  4XT4 A;  4KAK A;  5CC9 A;  2D5N A;  3SR5 X;  2CIG A;  3CSE A;  4ELB A;  4KJJ A;  3ZPG A;  4NX7 A;  4X5G A;  1VDR A;  1ZDR A;  3SRR X;  4PDJ A;  3DRC A;  4H96 A;  3NXY A;  3CD2 A;  3GHV A;  3QLZ A;  1RX8 A;  2C2S A;  4Q0D A;  1RC4 A;  3SRU X;  5DXV A;  1IA4 A;  4FHB A;  3I3R A;  3LG4 A;  4LEK X;  2W9T A;  4I13 A;  4M7V A;  3FY9 X;  1M7A A;  3GHW A;  4GH8 A;  1DRF A;  5ECC A;  4Q67 A;  3DL5 A;  2GD9 A;  4OSG A;  5HQZ A;  3EX8 A;  3CLB A;  3QL0 A;  4XE6 X;  1DR1 A;  1RX7 A;  2ZZA A;  4QJZ D;  3R33 A;  4M7U A;  1DRE A;  1PD8 A;  4CD2 A;  3KY8 A;  4KEB A;  4EIL A;  4IXF X;  3HBB A;  3JWM A;  5DFR A;  1U71 A;  5JG0 X;  3GI2 A;  3K2H A;  4EJ1 A;  4KFJ A;  3EIG A;  3FRF X;  1LY3 A;  3FRE X;  4H95 A;  4HOF A;  5HVE A;  3SA1 A;  5FDA A;  1DIS A;  1D1G A;  3F0Q X;  2W3A A;  4G3M A;  1OHK A;  1PDB A;  3DAU A;  4KJL A;  3JVX A;  4LAE X;  3NXT A;  3ZPC A;  5CCC A;  3NZB X;  4ECK A;  3QLS A;  1DR7 A;  3FS6 A;  1S3U A;  3UM6 A;  4P68 A;  3NZ9 X;  3TQ8 A;  3QLY A;  2H2Q A;  1DRA A;  2O7P A;  4P3R A;  3S7A A;  4EIG A;  1IA3 A;  1IA2 A;  3JSU A;  1DIU A;  3F0B X;  4DPD A;  2W9H A;  1MVS A;  1RD7 A;  2OBC A;  2ITH A;  4KL9 A;  5HSU A;  3EEK A;  7DFR A;  3DG8 A;  3F91 A;  4IXE D;  3FYW X;  8DFR A;  4PTJ A;  1JUV A;  2QK8 A;  3NXX A;  3L3R A;  3UM5 A;  2DRC A;  1RE7 A;  1S3W A;  4LAG X;  3F0U X;  2BLA A;  4PSS A;  3GYF A;  3F0V X;  5HUI A;  4I1N A;  2W3W A;  1DG5 A;  1DG8 A;  3IX9 A;  1YHO A;  2FZH A;  5U26 A;  5HVB A;  2LF1 A;  3IRO A;  2OIP A;  3IRN A;  3VCO A;  4ELG A;  1LY4 A;  3JWK A;  4KNE A;  4KBN A;  3TQ9 A;  4KD7 A;  3KGY A;  4HA9 A;  4QLF A;  3S3V A;  1LUD A;  2DHF A;  2FZJ A;  4PTH A;  3OAF A;  3K45 A;  4XT6 A;  4P66 A;  1J3K A;  1DDS A;  6DFR A;  5HSR A;  3HJ3 A;  3D80 A;  3IA4 A;  4H98 A;  3KFY A;  2KGK A;  1RX2 A;  3NU0 A;  1U70 A;  4FGH A;  4TU5 X;  2XW7 A;  5EAJ A;  3FRD X;  1RA8 A;  1RX9 A;  3NZC X;  4IXG X;  3I8A X;  5HI6 A;  3FQ0 A;  3QLR A;  4KM2 A;  3RG9 A;  3K47 A;  4QJC A;  2HXV A;  1DRB A;  3K74 A;  1BOZ A;  3NZ6 X;  5HQY A;  3QLW A;  2W3M A;  1RA9 A;  1DYI A;  3FQO A;  1SEJ A;  1RX4 A;  1TDR A; 
#chains in the Genus database with same CATH topology
 5E8Q A;  3NXO A;  1MVT A;  1S3Y A;  2P4G A;  3NRR A;  3QYL A;  1RA2 A;  4ELH A;  3UM8 A;  4P3Q A;  1JOM A;  2L28 A;  4M2X A;  4X5F A;  1RX3 A;  4X5H A;  3INV A;  3EEM A;  1DLS A;  4QI9 A;  4QLE A;  3TQB A;  1RG7 A;  1DAJ A;  1QZF A;  4XEC X;  3JWC A;  3CL9 A;  2C2T A;  4Q6A A;  4KYA A;  3E0B A;  1S3V A;  3F0S X;  3NTZ A;  1HFR A;  1DR4 A;  5ECX A;  3SRW X;  3D84 X;  4DFR A;  3GHC A;  1RB2 A;  3QGT A;  3IRM A;  1E26 A;  1DLR A;  3SRQ X;  3NZA X;  1DR3 A;  2ANO A;  2D0K A;  3FQZ A;  1DYR A;  3RO9 A;  1DYH A;  3DFR A;  2INQ A;  4LAH X;  3FY8 X;  3FRA X;  4DP3 A;  3QLX A;  3QYO A;  4NX6 A;  3IA5 A;  1BZF A;  3KJS A;  1DR5 A;  4FGG A;  4H97 A;  3FQF A;  1J3J A;  3FQC A;  4HA7 A;  1M79 A;  1CZ3 A;  2CD2 A;  4PSY A;  1DRH A;  3JW3 A;  2W3V A;  1KMS A;  4X5I A;  3KJR A;  1AOE A;  1JOL A;  1DHJ A;  2HM9 A;  2JYB A;  3SGY A;  3FQV A;  4M6K A;  3EEL A;  1RX6 A;  4OR7 A;  4RGC A;  1M78 A;  1DYJ A;  4KJK A;  4XRB A;  2BL9 A;  1DDR A;  1DHI A;  1RA3 A;  3TQA A;  5HF0 X;  2FZI A;  4KLX A;  5HF2 X;  3FYV X;  1DR2 A;  3Q1H A;  4KM0 A;  1IA1 A;  4G8Z X;  4ELE A;  1RA1 A;  3JWF A;  1PD9 A;  5HPB A;  2BLC A;  3OCH A;  3QL3 A;  4PST A;  2G6V A;  1RX1 A;  2ANQ A;  3N0H A;  4M6L A;  3SAI A;  3QFX A;  1KMV A;  5JA3 A;  1VJ3 A;  3NXR A;  3FL9 A;  2B3Z A;  1CD2 A;  2W9S A;  3NXV A;  4G95 A;  5HT5 A;  3NZD A;  4XT8 A;  3SA2 A;  4ELF A;  4Q0E A;  3DL6 A;  1AO8 A;  4QLG A;  5HT4 A;  3F0X X;  3F8Y A;  2HQP A;  2W3B A;  2W9G A;  1DHF A;  5U27 A;  4EIZ A;  3S9U A;  3FRB X;  3SRS X;  3M09 A;  4KY8 A;  1RH3 A;  1RB3 A;  1RX5 A;  3M08 A;  2AZN A;  3TD8 A;  4M6J A;  1J3I A;  4DPH A;  3JTW A;  1U72 A;  4DDR A;  3DAT A;  1KLK A;  1HFP A;  1OHJ A;  4KY4 A;  4HOG A;  3DGA A;  4QHV A;  1DR6 A;  1DG7 A;  4XT5 A;  4HOE A;  3JW5 A;  1AI9 A;  3QG2 A;  3EEJ A;  4X5J A;  3F8Z A;  1HFQ A;  2BLB A;  1RF7 A;  1DF7 A;  3SH2 A;  3FL8 A;  3SQY X;  3ROA A;  4XT7 A;  4XT4 A;  4KAK A;  5CC9 A;  2D5N A;  3SR5 X;  2CIG A;  3CSE A;  4ELB A;  4KJJ A;  3ZPG A;  4NX7 A;  4X5G A;  1VDR A;  1ZDR A;  3SRR X;  4PDJ A;  3DRC A;  4H96 A;  3NXY A;  3CD2 A;  3GHV A;  3QLZ A;  1RX8 A;  2C2S A;  4Q0D A;  1RC4 A;  3SRU X;  5DXV A;  1IA4 A;  4FHB A;  3I3R A;  3LG4 A;  4LEK X;  2W9T A;  4I13 A;  4M7V A;  3FY9 X;  1M7A A;  3GHW A;  4GH8 A;  1DRF A;  5ECC A;  4Q67 A;  3DL5 A;  2GD9 A;  4OSG A;  5HQZ A;  3EX8 A;  3CLB A;  3QL0 A;  4XE6 X;  1DR1 A;  1RX7 A;  2ZZA A;  4QJZ D;  3R33 A;  4M7U A;  1DRE A;  1PD8 A;  4CD2 A;  3KY8 A;  4KEB A;  4EIL A;  4IXF X;  3HBB A;  3JWM A;  5DFR A;  1U71 A;  5JG0 X;  3GI2 A;  3K2H A;  4EJ1 A;  4KFJ A;  3EIG A;  3FRF X;  1LY3 A;  3FRE X;  4H95 A;  4HOF A;  5HVE A;  3SA1 A;  5FDA A;  1DIS A;  1D1G A;  3F0Q X;  2W3A A;  4G3M A;  1OHK A;  1PDB A;  3DAU A;  4KJL A;  3JVX A;  4LAE X;  3NXT A;  3ZPC A;  5CCC A;  3NZB X;  4ECK A;  3QLS A;  1DR7 A;  3FS6 A;  1S3U A;  3UM6 A;  4P68 A;  3NZ9 X;  3TQ8 A;  3QLY A;  2H2Q A;  1DRA A;  2O7P A;  4P3R A;  3S7A A;  4EIG A;  1IA3 A;  1IA2 A;  3JSU A;  1DIU A;  3F0B X;  4DPD A;  2W9H A;  1MVS A;  1RD7 A;  2OBC A;  2ITH A;  4KL9 A;  5HSU A;  3EEK A;  7DFR A;  3DG8 A;  3F91 A;  4IXE D;  3FYW X;  8DFR A;  4PTJ A;  1JUV A;  2QK8 A;  3NXX A;  3L3R A;  3UM5 A;  2DRC A;  1RE7 A;  1S3W A;  4LAG X;  3F0U X;  2BLA A;  4PSS A;  3GYF A;  3F0V X;  5HUI A;  4I1N A;  2W3W A;  1DG5 A;  1DG8 A;  3IX9 A;  1YHO A;  2FZH A;  5U26 A;  5HVB A;  2LF1 A;  3IRO A;  2OIP A;  3IRN A;  3VCO A;  4ELG A;  1LY4 A;  3JWK A;  4KNE A;  4KBN A;  3TQ9 A;  4KD7 A;  3KGY A;  4HA9 A;  4QLF A;  3S3V A;  1LUD A;  2DHF A;  2FZJ A;  4PTH A;  3OAF A;  3K45 A;  4XT6 A;  4P66 A;  1J3K A;  1DDS A;  6DFR A;  5HSR A;  3HJ3 A;  3D80 A;  3IA4 A;  4H98 A;  3KFY A;  2KGK A;  1RX2 A;  3NU0 A;  1U70 A;  4FGH A;  4TU5 X;  2XW7 A;  5EAJ A;  3FRD X;  1RA8 A;  1RX9 A;  3NZC X;  4IXG X;  3I8A X;  5HI6 A;  3FQ0 A;  3QLR A;  4KM2 A;  3RG9 A;  3K47 A;  4QJC A;  2HXV A;  1DRB A;  3K74 A;  1BOZ A;  3NZ6 X;  5HQY A;  3QLW A;  2W3M A;  1RA9 A;  1DYI A;  3FQO A;  1SEJ A;  1RX4 A;  1TDR A; 
#chains in the Genus database with same CATH homology
 5E8Q A;  3NXO A;  1MVT A;  1S3Y A;  2P4G A;  3NRR A;  3QYL A;  1RA2 A;  4ELH A;  3UM8 A;  4P3Q A;  1JOM A;  2L28 A;  4M2X A;  4X5F A;  1RX3 A;  4X5H A;  3INV A;  3EEM A;  1DLS A;  4QI9 A;  4QLE A;  3TQB A;  1RG7 A;  1DAJ A;  1QZF A;  4XEC X;  3JWC A;  3CL9 A;  2C2T A;  4Q6A A;  4KYA A;  3E0B A;  1S3V A;  3F0S X;  3NTZ A;  1HFR A;  1DR4 A;  5ECX A;  3SRW X;  3D84 X;  4DFR A;  3GHC A;  1RB2 A;  3QGT A;  3IRM A;  1E26 A;  1DLR A;  3SRQ X;  3NZA X;  1DR3 A;  2ANO A;  2D0K A;  3FQZ A;  1DYR A;  3RO9 A;  1DYH A;  3DFR A;  2INQ A;  4LAH X;  3FY8 X;  3FRA X;  4DP3 A;  3QLX A;  3QYO A;  4NX6 A;  3IA5 A;  1BZF A;  3KJS A;  1DR5 A;  4FGG A;  4H97 A;  3FQF A;  1J3J A;  3FQC A;  4HA7 A;  1M79 A;  1CZ3 A;  2CD2 A;  4PSY A;  1DRH A;  3JW3 A;  2W3V A;  1KMS A;  4X5I A;  3KJR A;  1AOE A;  1JOL A;  1DHJ A;  2HM9 A;  2JYB A;  3SGY A;  3FQV A;  4M6K A;  3EEL A;  1RX6 A;  4OR7 A;  4RGC A;  1M78 A;  1DYJ A;  4KJK A;  4XRB A;  2BL9 A;  1DDR A;  1DHI A;  1RA3 A;  3TQA A;  5HF0 X;  2FZI A;  4KLX A;  5HF2 X;  3FYV X;  1DR2 A;  3Q1H A;  4KM0 A;  1IA1 A;  4G8Z X;  4ELE A;  1RA1 A;  3JWF A;  1PD9 A;  5HPB A;  2BLC A;  3OCH A;  3QL3 A;  4PST A;  2G6V A;  1RX1 A;  2ANQ A;  3N0H A;  4M6L A;  3SAI A;  3QFX A;  1KMV A;  5JA3 A;  1VJ3 A;  3NXR A;  3FL9 A;  2B3Z A;  1CD2 A;  2W9S A;  3NXV A;  4G95 A;  5HT5 A;  3NZD A;  4XT8 A;  3SA2 A;  4ELF A;  4Q0E A;  3DL6 A;  1AO8 A;  4QLG A;  5HT4 A;  3F0X X;  3F8Y A;  2HQP A;  2W3B A;  2W9G A;  1DHF A;  5U27 A;  4EIZ A;  3S9U A;  3FRB X;  3SRS X;  3M09 A;  4KY8 A;  1RH3 A;  1RB3 A;  1RX5 A;  3M08 A;  2AZN A;  3TD8 A;  4M6J A;  1J3I A;  4DPH A;  3JTW A;  1U72 A;  4DDR A;  3DAT A;  1KLK A;  1HFP A;  1OHJ A;  4KY4 A;  4HOG A;  3DGA A;  4QHV A;  1DR6 A;  1DG7 A;  4XT5 A;  4HOE A;  3JW5 A;  1AI9 A;  3QG2 A;  3EEJ A;  4X5J A;  3F8Z A;  1HFQ A;  2BLB A;  1RF7 A;  1DF7 A;  3SH2 A;  3FL8 A;  3SQY X;  3ROA A;  4XT7 A;  4XT4 A;  4KAK A;  5CC9 A;  2D5N A;  3SR5 X;  2CIG A;  3CSE A;  4ELB A;  4KJJ A;  3ZPG A;  4NX7 A;  4X5G A;  1VDR A;  1ZDR A;  3SRR X;  4PDJ A;  3DRC A;  4H96 A;  3NXY A;  3CD2 A;  3GHV A;  3QLZ A;  1RX8 A;  2C2S A;  4Q0D A;  1RC4 A;  3SRU X;  5DXV A;  1IA4 A;  4FHB A;  3I3R A;  3LG4 A;  4LEK X;  2W9T A;  4I13 A;  4M7V A;  3FY9 X;  1M7A A;  3GHW A;  4GH8 A;  1DRF A;  5ECC A;  4Q67 A;  3DL5 A;  2GD9 A;  4OSG A;  5HQZ A;  3EX8 A;  3CLB A;  3QL0 A;  4XE6 X;  1DR1 A;  1RX7 A;  2ZZA A;  4QJZ D;  3R33 A;  4M7U A;  1DRE A;  1PD8 A;  4CD2 A;  3KY8 A;  4KEB A;  4EIL A;  4IXF X;  3HBB A;  3JWM A;  5DFR A;  1U71 A;  5JG0 X;  3GI2 A;  3K2H A;  4EJ1 A;  4KFJ A;  3EIG A;  3FRF X;  1LY3 A;  3FRE X;  4H95 A;  4HOF A;  5HVE A;  3SA1 A;  5FDA A;  1DIS A;  1D1G A;  3F0Q X;  2W3A A;  4G3M A;  1OHK A;  1PDB A;  3DAU A;  4KJL A;  3JVX A;  4LAE X;  3NXT A;  3ZPC A;  5CCC A;  3NZB X;  4ECK A;  3QLS A;  1DR7 A;  3FS6 A;  1S3U A;  3UM6 A;  4P68 A;  3NZ9 X;  3TQ8 A;  3QLY A;  2H2Q A;  1DRA A;  2O7P A;  4P3R A;  3S7A A;  4EIG A;  1IA3 A;  1IA2 A;  3JSU A;  1DIU A;  3F0B X;  4DPD A;  2W9H A;  1MVS A;  1RD7 A;  2OBC A;  2ITH A;  4KL9 A;  5HSU A;  3EEK A;  7DFR A;  3DG8 A;  3F91 A;  4IXE D;  3FYW X;  8DFR A;  4PTJ A;  1JUV A;  2QK8 A;  3NXX A;  3L3R A;  3UM5 A;  2DRC A;  1RE7 A;  1S3W A;  4LAG X;  3F0U X;  2BLA A;  4PSS A;  3GYF A;  3F0V X;  5HUI A;  4I1N A;  2W3W A;  1DG5 A;  1DG8 A;  3IX9 A;  1YHO A;  2FZH A;  5U26 A;  5HVB A;  2LF1 A;  3IRO A;  2OIP A;  3IRN A;  3VCO A;  4ELG A;  1LY4 A;  3JWK A;  4KNE A;  4KBN A;  3TQ9 A;  4KD7 A;  3KGY A;  4HA9 A;  4QLF A;  3S3V A;  1LUD A;  2DHF A;  2FZJ A;  4PTH A;  3OAF A;  3K45 A;  4XT6 A;  4P66 A;  1J3K A;  1DDS A;  6DFR A;  5HSR A;  3HJ3 A;  3D80 A;  3IA4 A;  4H98 A;  3KFY A;  2KGK A;  1RX2 A;  3NU0 A;  1U70 A;  4FGH A;  4TU5 X;  2XW7 A;  5EAJ A;  3FRD X;  1RA8 A;  1RX9 A;  3NZC X;  4IXG X;  3I8A X;  5HI6 A;  3FQ0 A;  3QLR A;  4KM2 A;  3RG9 A;  3K47 A;  4QJC A;  2HXV A;  1DRB A;  3K74 A;  1BOZ A;  3NZ6 X;  5HQY A;  3QLW A;  2W3M A;  1RA9 A;  1DYI A;  3FQO A;  1SEJ A;  1RX4 A;  1TDR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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