5HT5A

6-substituted pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl)
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(4'-methoxyphenythio)[2,3-d]pyrrolo-7-ethyl-2,4-diamines
rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 53
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-01-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5ht5A00
5CC9A 3FQVA 1LUDA 3QYLA 1RE7A 1RF7A 1KMSA 2KGKA 3NU0A 5E8QA 4RGCA 1AI9A 3F0QX 3I3RA 4XT4A 1U72A 4DFRA 1IA1A 3SRRX 1IA4A 4XT6A 4IXED 3E0BA 1RX1A 5HQZA 2CIGA 4EILA 3SRSX 2BLAA 4HA7A 3JW3A 2JYBA 2HQPA 3DG8A 4XT5A 1RX2A 1DR1A 1DR4A 4FGGA 3SR5X 3TQ9A 5HSUA 3DRCA 2W9GA 3TQ8A 4QJZD 4KJKA 5U26A 4ELFA 3CSEA 3GYFA 3F0UX 3F0BX 3KGYA 2W9HA 1MVTA 5HT5A 4LAGX 3GHVA 1DRBA 1SEJA 4H98A 1U71A 4G8ZX 5HPBA 2P4GA 4KJLA 5EAJA 1OHKA 2BLBA 6DFRA 4M7UA 3INVA 1PD9A 3S7AA 4P3QA 2G6VA 3NXOA 2D0KA 3NZ9X 1AO8A 1JOLA 2XW7A 3M09A 3DAUA 3QLRA 3K45A 1DREA 4FGHA 4ELHA 1OHJA 4M6LA 3FQFA 3FQ0A 3ROAA 2ANQA 4KYAA 3JWCA 2LF1A 4ELEA 1DLSA 4P3RA 1DHJA 3LG4A 4XECX 7DFRA 2H2QA 3IROA 3K2HA 4KNEA 4IXGX 2CD2A 3QLXA 1LY4A 3NZBX 1TDRA 3NRRA 3NTZA 4HOEA 5CCCA 5HF2X 3FL9A 3OAFA 3GI2A 3QLZA 1E26A 3F0VX 3GHCA 1M7AA 5HVEA 1JUVA 3DL5A 2HM9A 2W3AA 3R33A 2C2TA 2ANOA 4HOGA 3F8ZA 1DG5A 2BLCA 4H95A 3NZCX 2HXVA 3D80A 1J3JA 4LAEX 1DLRA 1RX6A 3NXVA 1DYHA 4PTHA 3FRFX 3UM5A 3DATA 3SQYX 3JTWA 4Q6AA 3F8YA 4PSYA 4CD2A 1DR3A 3EEMA 3RG9A 4X5JA 2ITHA 4X5IA 4EIZA 1JOMA 2W9TA 3NZAX 2BL9A 3K47A 1RX7A 4PSSA 1AOEA 1DR5A 1KMVA 4PTJA 1DHFA 1RA2A 8DFRA 4G95A 3UM6A 3N0HA 1S3WA 2W3WA 2FZIA 1HFRA 3CD2A 5HVBA 2QK8A 3EX8A 2GD9A 3IA4A 3QLYA 3KFYA 4XT7A 1DR2A 5ECCA 1DAJA 4ELGA 1CD2A 4OR7A 3NZDA 2ZZAA 3SA2A 4DDRA 3TD8A 2FZHA 2OBCA 4FHBA 3QLSA 1IA3A 1M78A 3EEJA 5FDAA 1DR7A 4TU5X 3SGYA 3FQCA 4Q0EA 4HA9A 3S3VA 3TQAA 1RX8A 3SRQX 4P66A 2INQA 1DRFA 3FRAX 1DF7A 4HOFA 3SA1A 3OCHA 1D1GA 5HUIA 3RO9A 1DYIA 3HJ3A 4KFJA 1DR6A 3FY8X 4KJJA 3DGAA 3L3RA 1RD7A 3IRNA 4KD7A 3NXYA 3CLBA 1KLKA 3SRWX 5HI6A 1IA2A 4DPHA 1DG8A 4M7VA 3FY9X 4KM0A 5U27A 1RX3A 3JW5A 4M2XA 3EELA 1LY3A 5JA3A 3S9UA 3NZ6X 3ZPGA 4XT8A 3FL8A 3FYWX 1BZFA 4EIGA 1S3YA 4QI9A 5HSRA 4KY8A 4XE6X 2W3BA 1MVSA 1RA9A 4KAKA 5HQYA 1RA1A 1RG7A 1PDBA 2L28A 3FS6A 4LAHX 4Q67A 1DDSA 4EJ1A 4G3MA 3SAIA 4KY4A 1J3KA 4X5FA 1PD8A 4M6KA 1DYJA 2DRCA 3DFRA 3QYOA 2B3ZA 1VJ3A 4I1NA 4KL9A 4KBNA 1CZ3A 3F91A 4XRBA 3JVXA 5JG0X 3KJSA 4KLXA 1DHIA 1RH3A 4PDJA 3NXTA 3F0SX 3FREX 1J3IA 3SRUX 3KJRA 3QL0A 1DRHA 5DXVA 1S3UA 3K74A 3FYVX 1DYRA 1DIUA 3QGTA 4KEBA 2OIPA 1BOZA 4QLGA 3SH2A 1S3VA 1RC4A 4I13A 1VDRA 4PSTA 3ZPCA 1DISA 3FRBX 4GH8A 2O7PA 4DP3A 4ELBA 3FQOA 4KM2A 1U70A 3JWFA 3QL3A 4M6JA 3HBBA 1RX9A 1QZFA 3NXXA 3DL6A 3QFXA 1RX4A 1M79A 3QLWA 2D5NA 1ZDRA 4LEKX 2C2SA 5HF0X 3VCOA 3D84X 3F0XX 3JWMA 3IA5A 4NX6A 2FZJA 3EEKA 3EIGA 4Q0DA 3KY8A 3CL9A 4X5HA 4QJCA 4OSGA 4NX7A 5DFRA 3JSUA 1RB3A 3IX9A 3IRMA 4H96A 2AZNA 1DRAA 3I8AX 3NXRA 3QG2A 4DPDA 4QLFA 3UM8A 4P68A 4QLEA 3JWKA 2W9SA 1RA3A 3GHWA 1RB2A 2W3VA 5ECXA 1HFPA 3TQBA 4IXFX 2DHFA 1HFQA 1RA8A 5HT4A 1YHOA 3Q1HA 3FRDX 3M08A 1RX5A 2W3MA 1DG7A 3FQZA 4QHVA 4X5GA 4H97A 4ECKA 1DDRA
chains in the Genus database with same CATH superfamily
5CC9A 3FQVA 1LUDA 3QYLA 1RE7A 1RF7A 1KMSA 2KGKA 3NU0A 5E8QA 4RGCA 1AI9A 3F0QX 3I3RA 4XT4A 1U72A 4DFRA 1IA1A 3SRRX 1IA4A 4XT6A 4IXED 3E0BA 1RX1A 5HQZA 2CIGA 4EILA 3SRSX 2BLAA 4HA7A 3JW3A 2JYBA 2HQPA 3DG8A 4XT5A 1RX2A 1DR1A 1DR4A 4FGGA 3SR5X 3TQ9A 5HSUA 3DRCA 2W9GA 3TQ8A 4QJZD 4KJKA 5U26A 4ELFA 3CSEA 3GYFA 3F0UX 3F0BX 3KGYA 2W9HA 1MVTA 5HT5A 4LAGX 3GHVA 1DRBA 1SEJA 4H98A 1U71A 4G8ZX 5HPBA 2P4GA 4KJLA 5EAJA 1OHKA 2BLBA 6DFRA 4M7UA 3INVA 1PD9A 3S7AA 4P3QA 2G6VA 3NXOA 2D0KA 3NZ9X 1AO8A 1JOLA 2XW7A 3M09A 3DAUA 3QLRA 3K45A 1DREA 4FGHA 4ELHA 1OHJA 4M6LA 3FQFA 3FQ0A 3ROAA 2ANQA 4KYAA 3JWCA 2LF1A 4ELEA 1DLSA 4P3RA 1DHJA 3LG4A 4XECX 7DFRA 2H2QA 3IROA 3K2HA 4KNEA 4IXGX 2CD2A 3QLXA 1LY4A 3NZBX 1TDRA 3NRRA 3NTZA 4HOEA 5CCCA 5HF2X 3FL9A 3OAFA 3GI2A 3QLZA 1E26A 3F0VX 3GHCA 1M7AA 5HVEA 1JUVA 3DL5A 2HM9A 2W3AA 3R33A 2C2TA 2ANOA 4HOGA 3F8ZA 1DG5A 2BLCA 4H95A 3NZCX 2HXVA 3D80A 1J3JA 4LAEX 1DLRA 1RX6A 3NXVA 1DYHA 4PTHA 3FRFX 3UM5A 3DATA 3SQYX 3JTWA 4Q6AA 3F8YA 4PSYA 4CD2A 1DR3A 3EEMA 3RG9A 4X5JA 2ITHA 4X5IA 4EIZA 1JOMA 2W9TA 3NZAX 2BL9A 3K47A 1RX7A 4PSSA 1AOEA 1DR5A 1KMVA 4PTJA 1DHFA 1RA2A 8DFRA 4G95A 3UM6A 3N0HA 1S3WA 2W3WA 2FZIA 1HFRA 3CD2A 5HVBA 2QK8A 3EX8A 2GD9A 3IA4A 3QLYA 3KFYA 4XT7A 1DR2A 5ECCA 1DAJA 4ELGA 1CD2A 4OR7A 3NZDA 2ZZAA 3SA2A 4DDRA 3TD8A 2FZHA 2OBCA 4FHBA 3QLSA 1IA3A 1M78A 3EEJA 5FDAA 1DR7A 4TU5X 3SGYA 3FQCA 4Q0EA 4HA9A 3S3VA 3TQAA 1RX8A 3SRQX 4P66A 2INQA 1DRFA 3FRAX 1DF7A 4HOFA 3SA1A 3OCHA 1D1GA 5HUIA 3RO9A 1DYIA 3HJ3A 4KFJA 1DR6A 3FY8X 4KJJA 3DGAA 3L3RA 1RD7A 3IRNA 4KD7A 3NXYA 3CLBA 1KLKA 3SRWX 5HI6A 1IA2A 4DPHA 1DG8A 4M7VA 3FY9X 4KM0A 5U27A 1RX3A 3JW5A 4M2XA 3EELA 1LY3A 5JA3A 3S9UA 3NZ6X 3ZPGA 4XT8A 3FL8A 3FYWX 1BZFA 4EIGA 1S3YA 4QI9A 5HSRA 4KY8A 4XE6X 2W3BA 1MVSA 1RA9A 4KAKA 5HQYA 1RA1A 1RG7A 1PDBA 2L28A 3FS6A 4LAHX 4Q67A 1DDSA 4EJ1A 4G3MA 3SAIA 4KY4A 1J3KA 4X5FA 1PD8A 4M6KA 1DYJA 2DRCA 3DFRA 3QYOA 2B3ZA 1VJ3A 4I1NA 4KL9A 4KBNA 1CZ3A 3F91A 4XRBA 3JVXA 5JG0X 3KJSA 4KLXA 1DHIA 1RH3A 4PDJA 3NXTA 3F0SX 3FREX 1J3IA 3SRUX 3KJRA 3QL0A 1DRHA 5DXVA 1S3UA 3K74A 3FYVX 1DYRA 1DIUA 3QGTA 4KEBA 2OIPA 1BOZA 4QLGA 3SH2A 1S3VA 1RC4A 4I13A 1VDRA 4PSTA 3ZPCA 1DISA 3FRBX 4GH8A 2O7PA 4DP3A 4ELBA 3FQOA 4KM2A 1U70A 3JWFA 3QL3A 4M6JA 3HBBA 1RX9A 1QZFA 3NXXA 3DL6A 3QFXA 1RX4A 1M79A 3QLWA 2D5NA 1ZDRA 4LEKX 2C2SA 5HF0X 3VCOA 3D84X 3F0XX 3JWMA 3IA5A 4NX6A 2FZJA 3EEKA 3EIGA 4Q0DA 3KY8A 3CL9A 4X5HA 4QJCA 4OSGA 4NX7A 5DFRA 3JSUA 1RB3A 3IX9A 3IRMA 4H96A 2AZNA 1DRAA 3I8AX 3NXRA 3QG2A 4DPDA 4QLFA 3UM8A 4P68A 4QLEA 3JWKA 2W9SA 1RA3A 3GHWA 1RB2A 2W3VA 5ECXA 1HFPA 3TQBA 4IXFX 2DHFA 1HFQA 1RA8A 5HT4A 1YHOA 3Q1HA 3FRDX 3M08A 1RX5A 2W3MA 1DG7A 3FQZA 4QHVA 4X5GA 4H97A 4ECKA 1DDRA
chains in the Genus database with same CATH topology
5CC9A 3FQVA 1LUDA 3QYLA 1RE7A 1RF7A 1KMSA 2KGKA 3NU0A 5E8QA 4RGCA 1AI9A 3F0QX 3I3RA 4XT4A 1U72A 4DFRA 1IA1A 3SRRX 1IA4A 4XT6A 4IXED 3E0BA 1RX1A 5HQZA 2CIGA 4EILA 3SRSX 2BLAA 4HA7A 3JW3A 2JYBA 2HQPA 3DG8A 4XT5A 1RX2A 1DR1A 1DR4A 4FGGA 3SR5X 3TQ9A 5HSUA 3DRCA 2W9GA 3TQ8A 4QJZD 4KJKA 5U26A 4ELFA 3CSEA 3GYFA 3F0UX 3F0BX 3KGYA 2W9HA 1MVTA 5HT5A 4LAGX 3GHVA 1DRBA 1SEJA 4H98A 1U71A 4G8ZX 5HPBA 2P4GA 4KJLA 5EAJA 1OHKA 2BLBA 6DFRA 4M7UA 3INVA 1PD9A 3S7AA 4P3QA 2G6VA 3NXOA 2D0KA 3NZ9X 1AO8A 1JOLA 2XW7A 3M09A 3DAUA 3QLRA 3K45A 1DREA 4FGHA 4ELHA 1OHJA 4M6LA 3FQFA 3FQ0A 3ROAA 2ANQA 4KYAA 3JWCA 2LF1A 4ELEA 1DLSA 4P3RA 1DHJA 3LG4A 4XECX 7DFRA 2H2QA 3IROA 3K2HA 4KNEA 4IXGX 2CD2A 3QLXA 1LY4A 3NZBX 1TDRA 3NRRA 3NTZA 4HOEA 5CCCA 5HF2X 3FL9A 3OAFA 3GI2A 3QLZA 1E26A 3F0VX 3GHCA 1M7AA 5HVEA 1JUVA 3DL5A 2HM9A 2W3AA 3R33A 2C2TA 2ANOA 4HOGA 3F8ZA 1DG5A 2BLCA 4H95A 3NZCX 2HXVA 3D80A 1J3JA 4LAEX 1DLRA 1RX6A 3NXVA 1DYHA 4PTHA 3FRFX 3UM5A 3DATA 3SQYX 3JTWA 4Q6AA 3F8YA 4PSYA 4CD2A 1DR3A 3EEMA 3RG9A 4X5JA 2ITHA 4X5IA 4EIZA 1JOMA 2W9TA 3NZAX 2BL9A 3K47A 1RX7A 4PSSA 1AOEA 1DR5A 1KMVA 4PTJA 1DHFA 1RA2A 8DFRA 4G95A 3UM6A 3N0HA 1S3WA 2W3WA 2FZIA 1HFRA 3CD2A 5HVBA 2QK8A 3EX8A 2GD9A 3IA4A 3QLYA 3KFYA 4XT7A 1DR2A 5ECCA 1DAJA 4ELGA 1CD2A 4OR7A 3NZDA 2ZZAA 3SA2A 4DDRA 3TD8A 2FZHA 2OBCA 4FHBA 3QLSA 1IA3A 1M78A 3EEJA 5FDAA 1DR7A 4TU5X 3SGYA 3FQCA 4Q0EA 4HA9A 3S3VA 3TQAA 1RX8A 3SRQX 4P66A 2INQA 1DRFA 3FRAX 1DF7A 4HOFA 3SA1A 3OCHA 1D1GA 5HUIA 3RO9A 1DYIA 3HJ3A 4KFJA 1DR6A 3FY8X 4KJJA 3DGAA 3L3RA 1RD7A 3IRNA 4KD7A 3NXYA 3CLBA 1KLKA 3SRWX 5HI6A 1IA2A 4DPHA 1DG8A 4M7VA 3FY9X 4KM0A 5U27A 1RX3A 3JW5A 4M2XA 3EELA 1LY3A 5JA3A 3S9UA 3NZ6X 3ZPGA 4XT8A 3FL8A 3FYWX 1BZFA 4EIGA 1S3YA 4QI9A 5HSRA 4KY8A 4XE6X 2W3BA 1MVSA 1RA9A 4KAKA 5HQYA 1RA1A 1RG7A 1PDBA 2L28A 3FS6A 4LAHX 4Q67A 1DDSA 4EJ1A 4G3MA 3SAIA 4KY4A 1J3KA 4X5FA 1PD8A 4M6KA 1DYJA 2DRCA 3DFRA 3QYOA 2B3ZA 1VJ3A 4I1NA 4KL9A 4KBNA 1CZ3A 3F91A 4XRBA 3JVXA 5JG0X 3KJSA 4KLXA 1DHIA 1RH3A 4PDJA 3NXTA 3F0SX 3FREX 1J3IA 3SRUX 3KJRA 3QL0A 1DRHA 5DXVA 1S3UA 3K74A 3FYVX 1DYRA 1DIUA 3QGTA 4KEBA 2OIPA 1BOZA 4QLGA 3SH2A 1S3VA 1RC4A 4I13A 1VDRA 4PSTA 3ZPCA 1DISA 3FRBX 4GH8A 2O7PA 4DP3A 4ELBA 3FQOA 4KM2A 1U70A 3JWFA 3QL3A 4M6JA 3HBBA 1RX9A 1QZFA 3NXXA 3DL6A 3QFXA 1RX4A 1M79A 3QLWA 2D5NA 1ZDRA 4LEKX 2C2SA 5HF0X 3VCOA 3D84X 3F0XX 3JWMA 3IA5A 4NX6A 2FZJA 3EEKA 3EIGA 4Q0DA 3KY8A 3CL9A 4X5HA 4QJCA 4OSGA 4NX7A 5DFRA 3JSUA 1RB3A 3IX9A 3IRMA 4H96A 2AZNA 1DRAA 3I8AX 3NXRA 3QG2A 4DPDA 4QLFA 3UM8A 4P68A 4QLEA 3JWKA 2W9SA 1RA3A 3GHWA 1RB2A 2W3VA 5ECXA 1HFPA 3TQBA 4IXFX 2DHFA 1HFQA 1RA8A 5HT4A 1YHOA 3Q1HA 3FRDX 3M08A 1RX5A 2W3MA 1DG7A 3FQZA 4QHVA 4X5GA 4H97A 4ECKA 1DDRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CC9 A;  3FQV A;  1LUD A;  3QYL A;  1RE7 A;  1RF7 A;  1KMS A;  2KGK A;  3NU0 A;  5E8Q A;  4RGC A;  1AI9 A;  3F0Q X;  3I3R A;  4XT4 A;  1U72 A;  4DFR A;  1IA1 A;  3SRR X;  1IA4 A;  4XT6 A;  4IXE D;  3E0B A;  1RX1 A;  5HQZ A;  2CIG A;  4EIL A;  3SRS X;  2BLA A;  4HA7 A;  3JW3 A;  2JYB A;  2HQP A;  3DG8 A;  4XT5 A;  1RX2 A;  1DR1 A;  1DR4 A;  4FGG A;  3SR5 X;  3TQ9 A;  5HSU A;  3DRC A;  2W9G A;  3TQ8 A;  4QJZ D;  4KJK A;  5U26 A;  4ELF A;  3CSE A;  3GYF A;  3F0U X;  3F0B X;  3KGY A;  2W9H A;  1MVT A;  5HT5 A;  4LAG X;  3GHV A;  1DRB A;  1SEJ A;  4H98 A;  1U71 A;  4G8Z X;  5HPB A;  2P4G A;  4KJL A;  5EAJ A;  1OHK A;  2BLB A;  6DFR A;  4M7U A;  3INV A;  1PD9 A;  3S7A A;  4P3Q A;  2G6V A;  3NXO A;  2D0K A;  3NZ9 X;  1AO8 A;  1JOL A;  2XW7 A;  3M09 A;  3DAU A;  3QLR A;  3K45 A;  1DRE A;  4FGH A;  4ELH A;  1OHJ A;  4M6L A;  3FQF A;  3FQ0 A;  3ROA A;  2ANQ A;  4KYA A;  3JWC A;  2LF1 A;  4ELE A;  1DLS A;  4P3R A;  1DHJ A;  3LG4 A;  4XEC X;  7DFR A;  2H2Q A;  3IRO A;  3K2H A;  4KNE A;  4IXG X;  2CD2 A;  3QLX A;  1LY4 A;  3NZB X;  1TDR A;  3NRR A;  3NTZ A;  4HOE A;  5CCC A;  5HF2 X;  3FL9 A;  3OAF A;  3GI2 A;  3QLZ A;  1E26 A;  3F0V X;  3GHC A;  1M7A A;  5HVE A;  1JUV A;  3DL5 A;  2HM9 A;  2W3A A;  3R33 A;  2C2T A;  2ANO A;  4HOG A;  3F8Z A;  1DG5 A;  2BLC A;  4H95 A;  3NZC X;  2HXV A;  3D80 A;  1J3J A;  4LAE X;  1DLR A;  1RX6 A;  3NXV A;  1DYH A;  4PTH A;  3FRF X;  3UM5 A;  3DAT A;  3SQY X;  3JTW A;  4Q6A A;  3F8Y A;  4PSY A;  4CD2 A;  1DR3 A;  3EEM A;  3RG9 A;  4X5J A;  2ITH A;  4X5I A;  4EIZ A;  1JOM A;  2W9T A;  3NZA X;  2BL9 A;  3K47 A;  1RX7 A;  4PSS A;  1AOE A;  1DR5 A;  1KMV A;  4PTJ A;  1DHF A;  1RA2 A;  8DFR A;  4G95 A;  3UM6 A;  3N0H A;  1S3W A;  2W3W A;  2FZI A;  1HFR A;  3CD2 A;  5HVB A;  2QK8 A;  3EX8 A;  2GD9 A;  3IA4 A;  3QLY A;  3KFY A;  4XT7 A;  1DR2 A;  5ECC A;  1DAJ A;  4ELG A;  1CD2 A;  4OR7 A;  3NZD A;  2ZZA A;  3SA2 A;  4DDR A;  3TD8 A;  2FZH A;  2OBC A;  4FHB A;  3QLS A;  1IA3 A;  1M78 A;  3EEJ A;  5FDA A;  1DR7 A;  4TU5 X;  3SGY A;  3FQC A;  4Q0E A;  4HA9 A;  3S3V A;  3TQA A;  1RX8 A;  3SRQ X;  4P66 A;  2INQ A;  1DRF A;  3FRA X;  1DF7 A;  4HOF A;  3SA1 A;  3OCH A;  1D1G A;  5HUI A;  3RO9 A;  1DYI A;  3HJ3 A;  4KFJ A;  1DR6 A;  3FY8 X;  4KJJ A;  3DGA A;  3L3R A;  1RD7 A;  3IRN A;  4KD7 A;  3NXY A;  3CLB A;  1KLK A;  3SRW X;  5HI6 A;  1IA2 A;  4DPH A;  1DG8 A;  4M7V A;  3FY9 X;  4KM0 A;  5U27 A;  1RX3 A;  3JW5 A;  4M2X A;  3EEL A;  1LY3 A;  5JA3 A;  3S9U A;  3NZ6 X;  3ZPG A;  4XT8 A;  3FL8 A;  3FYW X;  1BZF A;  4EIG A;  1S3Y A;  4QI9 A;  5HSR A;  4KY8 A;  4XE6 X;  2W3B A;  1MVS A;  1RA9 A;  4KAK A;  5HQY A;  1RA1 A;  1RG7 A;  1PDB A;  2L28 A;  3FS6 A;  4LAH X;  4Q67 A;  1DDS A;  4EJ1 A;  4G3M A;  3SAI A;  4KY4 A;  1J3K A;  4X5F A;  1PD8 A;  4M6K A;  1DYJ A;  2DRC A;  3DFR A;  3QYO A;  2B3Z A;  1VJ3 A;  4I1N A;  4KL9 A;  4KBN A;  1CZ3 A;  3F91 A;  4XRB A;  3JVX A;  5JG0 X;  3KJS A;  4KLX A;  1DHI A;  1RH3 A;  4PDJ A;  3NXT A;  3F0S X;  3FRE X;  1J3I A;  3SRU X;  3KJR A;  3QL0 A;  1DRH A;  5DXV A;  1S3U A;  3K74 A;  3FYV X;  1DYR A;  1DIU A;  3QGT A;  4KEB A;  2OIP A;  1BOZ A;  4QLG A;  3SH2 A;  1S3V A;  1RC4 A;  4I13 A;  1VDR A;  4PST A;  3ZPC A;  1DIS A;  3FRB X;  4GH8 A;  2O7P A;  4DP3 A;  4ELB A;  3FQO A;  4KM2 A;  1U70 A;  3JWF A;  3QL3 A;  4M6J A;  3HBB A;  1RX9 A;  1QZF A;  3NXX A;  3DL6 A;  3QFX A;  1RX4 A;  1M79 A;  3QLW A;  2D5N A;  1ZDR A;  4LEK X;  2C2S A;  5HF0 X;  3VCO A;  3D84 X;  3F0X X;  3JWM A;  3IA5 A;  4NX6 A;  2FZJ A;  3EEK A;  3EIG A;  4Q0D A;  3KY8 A;  3CL9 A;  4X5H A;  4QJC A;  4OSG A;  4NX7 A;  5DFR A;  3JSU A;  1RB3 A;  3IX9 A;  3IRM A;  4H96 A;  2AZN A;  1DRA A;  3I8A X;  3NXR A;  3QG2 A;  4DPD A;  4QLF A;  3UM8 A;  4P68 A;  4QLE A;  3JWK A;  2W9S A;  1RA3 A;  3GHW A;  1RB2 A;  2W3V A;  5ECX A;  1HFP A;  3TQB A;  4IXF X;  2DHF A;  1HFQ A;  1RA8 A;  5HT4 A;  1YHO A;  3Q1H A;  3FRD X;  3M08 A;  1RX5 A;  2W3M A;  1DG7 A;  3FQZ A;  4QHV A;  4X5G A;  4H97 A;  4ECK A;  1DDR A; 
#chains in the Genus database with same CATH topology
 5CC9 A;  3FQV A;  1LUD A;  3QYL A;  1RE7 A;  1RF7 A;  1KMS A;  2KGK A;  3NU0 A;  5E8Q A;  4RGC A;  1AI9 A;  3F0Q X;  3I3R A;  4XT4 A;  1U72 A;  4DFR A;  1IA1 A;  3SRR X;  1IA4 A;  4XT6 A;  4IXE D;  3E0B A;  1RX1 A;  5HQZ A;  2CIG A;  4EIL A;  3SRS X;  2BLA A;  4HA7 A;  3JW3 A;  2JYB A;  2HQP A;  3DG8 A;  4XT5 A;  1RX2 A;  1DR1 A;  1DR4 A;  4FGG A;  3SR5 X;  3TQ9 A;  5HSU A;  3DRC A;  2W9G A;  3TQ8 A;  4QJZ D;  4KJK A;  5U26 A;  4ELF A;  3CSE A;  3GYF A;  3F0U X;  3F0B X;  3KGY A;  2W9H A;  1MVT A;  5HT5 A;  4LAG X;  3GHV A;  1DRB A;  1SEJ A;  4H98 A;  1U71 A;  4G8Z X;  5HPB A;  2P4G A;  4KJL A;  5EAJ A;  1OHK A;  2BLB A;  6DFR A;  4M7U A;  3INV A;  1PD9 A;  3S7A A;  4P3Q A;  2G6V A;  3NXO A;  2D0K A;  3NZ9 X;  1AO8 A;  1JOL A;  2XW7 A;  3M09 A;  3DAU A;  3QLR A;  3K45 A;  1DRE A;  4FGH A;  4ELH A;  1OHJ A;  4M6L A;  3FQF A;  3FQ0 A;  3ROA A;  2ANQ A;  4KYA A;  3JWC A;  2LF1 A;  4ELE A;  1DLS A;  4P3R A;  1DHJ A;  3LG4 A;  4XEC X;  7DFR A;  2H2Q A;  3IRO A;  3K2H A;  4KNE A;  4IXG X;  2CD2 A;  3QLX A;  1LY4 A;  3NZB X;  1TDR A;  3NRR A;  3NTZ A;  4HOE A;  5CCC A;  5HF2 X;  3FL9 A;  3OAF A;  3GI2 A;  3QLZ A;  1E26 A;  3F0V X;  3GHC A;  1M7A A;  5HVE A;  1JUV A;  3DL5 A;  2HM9 A;  2W3A A;  3R33 A;  2C2T A;  2ANO A;  4HOG A;  3F8Z A;  1DG5 A;  2BLC A;  4H95 A;  3NZC X;  2HXV A;  3D80 A;  1J3J A;  4LAE X;  1DLR A;  1RX6 A;  3NXV A;  1DYH A;  4PTH A;  3FRF X;  3UM5 A;  3DAT A;  3SQY X;  3JTW A;  4Q6A A;  3F8Y A;  4PSY A;  4CD2 A;  1DR3 A;  3EEM A;  3RG9 A;  4X5J A;  2ITH A;  4X5I A;  4EIZ A;  1JOM A;  2W9T A;  3NZA X;  2BL9 A;  3K47 A;  1RX7 A;  4PSS A;  1AOE A;  1DR5 A;  1KMV A;  4PTJ A;  1DHF A;  1RA2 A;  8DFR A;  4G95 A;  3UM6 A;  3N0H A;  1S3W A;  2W3W A;  2FZI A;  1HFR A;  3CD2 A;  5HVB A;  2QK8 A;  3EX8 A;  2GD9 A;  3IA4 A;  3QLY A;  3KFY A;  4XT7 A;  1DR2 A;  5ECC A;  1DAJ A;  4ELG A;  1CD2 A;  4OR7 A;  3NZD A;  2ZZA A;  3SA2 A;  4DDR A;  3TD8 A;  2FZH A;  2OBC A;  4FHB A;  3QLS A;  1IA3 A;  1M78 A;  3EEJ A;  5FDA A;  1DR7 A;  4TU5 X;  3SGY A;  3FQC A;  4Q0E A;  4HA9 A;  3S3V A;  3TQA A;  1RX8 A;  3SRQ X;  4P66 A;  2INQ A;  1DRF A;  3FRA X;  1DF7 A;  4HOF A;  3SA1 A;  3OCH A;  1D1G A;  5HUI A;  3RO9 A;  1DYI A;  3HJ3 A;  4KFJ A;  1DR6 A;  3FY8 X;  4KJJ A;  3DGA A;  3L3R A;  1RD7 A;  3IRN A;  4KD7 A;  3NXY A;  3CLB A;  1KLK A;  3SRW X;  5HI6 A;  1IA2 A;  4DPH A;  1DG8 A;  4M7V A;  3FY9 X;  4KM0 A;  5U27 A;  1RX3 A;  3JW5 A;  4M2X A;  3EEL A;  1LY3 A;  5JA3 A;  3S9U A;  3NZ6 X;  3ZPG A;  4XT8 A;  3FL8 A;  3FYW X;  1BZF A;  4EIG A;  1S3Y A;  4QI9 A;  5HSR A;  4KY8 A;  4XE6 X;  2W3B A;  1MVS A;  1RA9 A;  4KAK A;  5HQY A;  1RA1 A;  1RG7 A;  1PDB A;  2L28 A;  3FS6 A;  4LAH X;  4Q67 A;  1DDS A;  4EJ1 A;  4G3M A;  3SAI A;  4KY4 A;  1J3K A;  4X5F A;  1PD8 A;  4M6K A;  1DYJ A;  2DRC A;  3DFR A;  3QYO A;  2B3Z A;  1VJ3 A;  4I1N A;  4KL9 A;  4KBN A;  1CZ3 A;  3F91 A;  4XRB A;  3JVX A;  5JG0 X;  3KJS A;  4KLX A;  1DHI A;  1RH3 A;  4PDJ A;  3NXT A;  3F0S X;  3FRE X;  1J3I A;  3SRU X;  3KJR A;  3QL0 A;  1DRH A;  5DXV A;  1S3U A;  3K74 A;  3FYV X;  1DYR A;  1DIU A;  3QGT A;  4KEB A;  2OIP A;  1BOZ A;  4QLG A;  3SH2 A;  1S3V A;  1RC4 A;  4I13 A;  1VDR A;  4PST A;  3ZPC A;  1DIS A;  3FRB X;  4GH8 A;  2O7P A;  4DP3 A;  4ELB A;  3FQO A;  4KM2 A;  1U70 A;  3JWF A;  3QL3 A;  4M6J A;  3HBB A;  1RX9 A;  1QZF A;  3NXX A;  3DL6 A;  3QFX A;  1RX4 A;  1M79 A;  3QLW A;  2D5N A;  1ZDR A;  4LEK X;  2C2S A;  5HF0 X;  3VCO A;  3D84 X;  3F0X X;  3JWM A;  3IA5 A;  4NX6 A;  2FZJ A;  3EEK A;  3EIG A;  4Q0D A;  3KY8 A;  3CL9 A;  4X5H A;  4QJC A;  4OSG A;  4NX7 A;  5DFR A;  3JSU A;  1RB3 A;  3IX9 A;  3IRM A;  4H96 A;  2AZN A;  1DRA A;  3I8A X;  3NXR A;  3QG2 A;  4DPD A;  4QLF A;  3UM8 A;  4P68 A;  4QLE A;  3JWK A;  2W9S A;  1RA3 A;  3GHW A;  1RB2 A;  2W3V A;  5ECX A;  1HFP A;  3TQB A;  4IXF X;  2DHF A;  1HFQ A;  1RA8 A;  5HT4 A;  1YHO A;  3Q1H A;  3FRD X;  3M08 A;  1RX5 A;  2W3M A;  1DG7 A;  3FQZ A;  4QHV A;  4X5G A;  4H97 A;  4ECK A;  1DDR A; 
#chains in the Genus database with same CATH homology
 5CC9 A;  3FQV A;  1LUD A;  3QYL A;  1RE7 A;  1RF7 A;  1KMS A;  2KGK A;  3NU0 A;  5E8Q A;  4RGC A;  1AI9 A;  3F0Q X;  3I3R A;  4XT4 A;  1U72 A;  4DFR A;  1IA1 A;  3SRR X;  1IA4 A;  4XT6 A;  4IXE D;  3E0B A;  1RX1 A;  5HQZ A;  2CIG A;  4EIL A;  3SRS X;  2BLA A;  4HA7 A;  3JW3 A;  2JYB A;  2HQP A;  3DG8 A;  4XT5 A;  1RX2 A;  1DR1 A;  1DR4 A;  4FGG A;  3SR5 X;  3TQ9 A;  5HSU A;  3DRC A;  2W9G A;  3TQ8 A;  4QJZ D;  4KJK A;  5U26 A;  4ELF A;  3CSE A;  3GYF A;  3F0U X;  3F0B X;  3KGY A;  2W9H A;  1MVT A;  5HT5 A;  4LAG X;  3GHV A;  1DRB A;  1SEJ A;  4H98 A;  1U71 A;  4G8Z X;  5HPB A;  2P4G A;  4KJL A;  5EAJ A;  1OHK A;  2BLB A;  6DFR A;  4M7U A;  3INV A;  1PD9 A;  3S7A A;  4P3Q A;  2G6V A;  3NXO A;  2D0K A;  3NZ9 X;  1AO8 A;  1JOL A;  2XW7 A;  3M09 A;  3DAU A;  3QLR A;  3K45 A;  1DRE A;  4FGH A;  4ELH A;  1OHJ A;  4M6L A;  3FQF A;  3FQ0 A;  3ROA A;  2ANQ A;  4KYA A;  3JWC A;  2LF1 A;  4ELE A;  1DLS A;  4P3R A;  1DHJ A;  3LG4 A;  4XEC X;  7DFR A;  2H2Q A;  3IRO A;  3K2H A;  4KNE A;  4IXG X;  2CD2 A;  3QLX A;  1LY4 A;  3NZB X;  1TDR A;  3NRR A;  3NTZ A;  4HOE A;  5CCC A;  5HF2 X;  3FL9 A;  3OAF A;  3GI2 A;  3QLZ A;  1E26 A;  3F0V X;  3GHC A;  1M7A A;  5HVE A;  1JUV A;  3DL5 A;  2HM9 A;  2W3A A;  3R33 A;  2C2T A;  2ANO A;  4HOG A;  3F8Z A;  1DG5 A;  2BLC A;  4H95 A;  3NZC X;  2HXV A;  3D80 A;  1J3J A;  4LAE X;  1DLR A;  1RX6 A;  3NXV A;  1DYH A;  4PTH A;  3FRF X;  3UM5 A;  3DAT A;  3SQY X;  3JTW A;  4Q6A A;  3F8Y A;  4PSY A;  4CD2 A;  1DR3 A;  3EEM A;  3RG9 A;  4X5J A;  2ITH A;  4X5I A;  4EIZ A;  1JOM A;  2W9T A;  3NZA X;  2BL9 A;  3K47 A;  1RX7 A;  4PSS A;  1AOE A;  1DR5 A;  1KMV A;  4PTJ A;  1DHF A;  1RA2 A;  8DFR A;  4G95 A;  3UM6 A;  3N0H A;  1S3W A;  2W3W A;  2FZI A;  1HFR A;  3CD2 A;  5HVB A;  2QK8 A;  3EX8 A;  2GD9 A;  3IA4 A;  3QLY A;  3KFY A;  4XT7 A;  1DR2 A;  5ECC A;  1DAJ A;  4ELG A;  1CD2 A;  4OR7 A;  3NZD A;  2ZZA A;  3SA2 A;  4DDR A;  3TD8 A;  2FZH A;  2OBC A;  4FHB A;  3QLS A;  1IA3 A;  1M78 A;  3EEJ A;  5FDA A;  1DR7 A;  4TU5 X;  3SGY A;  3FQC A;  4Q0E A;  4HA9 A;  3S3V A;  3TQA A;  1RX8 A;  3SRQ X;  4P66 A;  2INQ A;  1DRF A;  3FRA X;  1DF7 A;  4HOF A;  3SA1 A;  3OCH A;  1D1G A;  5HUI A;  3RO9 A;  1DYI A;  3HJ3 A;  4KFJ A;  1DR6 A;  3FY8 X;  4KJJ A;  3DGA A;  3L3R A;  1RD7 A;  3IRN A;  4KD7 A;  3NXY A;  3CLB A;  1KLK A;  3SRW X;  5HI6 A;  1IA2 A;  4DPH A;  1DG8 A;  4M7V A;  3FY9 X;  4KM0 A;  5U27 A;  1RX3 A;  3JW5 A;  4M2X A;  3EEL A;  1LY3 A;  5JA3 A;  3S9U A;  3NZ6 X;  3ZPG A;  4XT8 A;  3FL8 A;  3FYW X;  1BZF A;  4EIG A;  1S3Y A;  4QI9 A;  5HSR A;  4KY8 A;  4XE6 X;  2W3B A;  1MVS A;  1RA9 A;  4KAK A;  5HQY A;  1RA1 A;  1RG7 A;  1PDB A;  2L28 A;  3FS6 A;  4LAH X;  4Q67 A;  1DDS A;  4EJ1 A;  4G3M A;  3SAI A;  4KY4 A;  1J3K A;  4X5F A;  1PD8 A;  4M6K A;  1DYJ A;  2DRC A;  3DFR A;  3QYO A;  2B3Z A;  1VJ3 A;  4I1N A;  4KL9 A;  4KBN A;  1CZ3 A;  3F91 A;  4XRB A;  3JVX A;  5JG0 X;  3KJS A;  4KLX A;  1DHI A;  1RH3 A;  4PDJ A;  3NXT A;  3F0S X;  3FRE X;  1J3I A;  3SRU X;  3KJR A;  3QL0 A;  1DRH A;  5DXV A;  1S3U A;  3K74 A;  3FYV X;  1DYR A;  1DIU A;  3QGT A;  4KEB A;  2OIP A;  1BOZ A;  4QLG A;  3SH2 A;  1S3V A;  1RC4 A;  4I13 A;  1VDR A;  4PST A;  3ZPC A;  1DIS A;  3FRB X;  4GH8 A;  2O7P A;  4DP3 A;  4ELB A;  3FQO A;  4KM2 A;  1U70 A;  3JWF A;  3QL3 A;  4M6J A;  3HBB A;  1RX9 A;  1QZF A;  3NXX A;  3DL6 A;  3QFX A;  1RX4 A;  1M79 A;  3QLW A;  2D5N A;  1ZDR A;  4LEK X;  2C2S A;  5HF0 X;  3VCO A;  3D84 X;  3F0X X;  3JWM A;  3IA5 A;  4NX6 A;  2FZJ A;  3EEK A;  3EIG A;  4Q0D A;  3KY8 A;  3CL9 A;  4X5H A;  4QJC A;  4OSG A;  4NX7 A;  5DFR A;  3JSU A;  1RB3 A;  3IX9 A;  3IRM A;  4H96 A;  2AZN A;  1DRA A;  3I8A X;  3NXR A;  3QG2 A;  4DPD A;  4QLF A;  3UM8 A;  4P68 A;  4QLE A;  3JWK A;  2W9S A;  1RA3 A;  3GHW A;  1RB2 A;  2W3V A;  5ECX A;  1HFP A;  3TQB A;  4IXF X;  2DHF A;  1HFQ A;  1RA8 A;  5HT4 A;  1YHO A;  3Q1H A;  3FRD X;  3M08 A;  1RX5 A;  2W3M A;  1DG7 A;  3FQZ A;  4QHV A;  4X5G A;  4H97 A;  4ECK A;  1DDR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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