5HVEA

5-methyl-6-(3'-trifluromethoxyphenylthio)[2,3-d]pyrimidine 2,4-diamine
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(4'-methoxyphenythio)[2,3-d]pyrrolo-7-ethyl-2,4-diamines
rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 60
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5hveA00
4EJ1A 1DHFA 5HT5A 3OCHA 3SQYX 1U71A 4ELHA 3I8AX 1DAJA 1DR1A 1CD2A 4Q0DA 1RX8A 2D5NA 4PSSA 3QYLA 2LF1A 3S7AA 4IXFX 5DFRA 4ELGA 4X5IA 3SRUX 1DYJA 4QLEA 1DR7A 1RA8A 1DR4A 4HA9A 2BLAA 2ANQA 3NZCX 1S3YA 1DR2A 1CZ3A 3N0HA 3NZ9X 2G6VA 4KBNA 1M78A 1KLKA 3S9UA 1LY3A 3CL9A 1HFQA 3DRCA 1RH3A 5HQYA 1DF7A 3S3VA 3NZ6X 3GHCA 1DG8A 5U27A 3DL5A 2H2QA 3JTWA 1AOEA 7DFRA 1DDSA 1HFRA 1RX7A 1DRHA 2B3ZA 4M7UA 3F0UX 4ELBA 3GYFA 3TQ9A 4HA7A 1AI9A 4H96A 3JW3A 4OR7A 1MVTA 2INQA 3RG9A 3QL0A 4I1NA 4H95A 3NXRA 3JSUA 4QJCA 3FREX 4KL9A 1DRAA 1E26A 3FY8X 3SRSX 3M08A 1ZDRA 1RG7A 4XECX 2KGKA 4P66A 4ELEA 3QFXA 3KJRA 5ECXA 3RO9A 4PDJA 4M7VA 4QI9A 1RF7A 3FRAX 4M6KA 3NXTA 4EILA 1RA1A 4XT8A 4LAEX 1PDBA 1DR6A 1RE7A 3NXXA 1RA2A 2L28A 2W3MA 1RX2A 1J3KA 1OHKA 5JG0X 4P3RA 1HFPA 2AZNA 3F8YA 4Q0EA 5HF2X 3FRBX 1RB2A 1JUVA 3IA4A 3GHVA 3SA2A 3F0BX 3FL9A 4DDRA 1KMSA 3SRRX 1U72A 1PD8A 3NU0A 1DG7A 4G3MA 4LAGX 2W3WA 3F91A 5DXVA 4QJZD 4GH8A 4QHVA 8DFRA 5JA3A 4X5GA 2JYBA 2W9GA 2W3BA 2HXVA 3FRDX 4PSYA 3TD8A 4IXGX 3FS6A 3I3RA 5CCCA 3D84X 1PD9A 3FYVX 3JWFA 5CC9A 4KM0A 5U26A 2W9SA 4KJKA 3F0XX 3NZBX 3KFYA 3FL8A 3IROA 4KEBA 3FY9X 4H97A 1DR5A 3HJ3A 1RX4A 2O7PA 3TQAA 1MVSA 3K2HA 3F0QX 5HVEA 4DP3A 3NZAX 5HF0X 1DYRA 3K74A 2ANOA 3QLZA 4PTHA 2FZJA 2ZZAA 4G8ZX 3FQVA 4KJLA 4M6LA 3UM6A 1DLRA 1VJ3A 3KGYA 2CD2A 2W9HA 3EIGA 1M7AA 4I13A 1DHIA 3UM8A 3NXVA 4QLGA 3ZPCA 1VDRA 2HQPA 3DATA 4FGGA 3FQ0A 3IX9A 4KFJA 3D80A 3VCOA 1LY4A 1DRBA 3ZPGA 1TDRA 3FYWX 4OSGA 2D0KA 1DDRA 3NXOA 3DGAA 3FQFA 2W3VA 3DAUA 3F0SX 4Q67A 5E8QA 4KD7A 1RX9A 3SA1A 1J3JA 4M2XA 4XT7A 3IRMA 3HBBA 1RA3A 4CD2A 1S3UA 4KY4A 4KLXA 4RGCA 3KY8A 2C2SA 2C2TA 1KMVA 3SRQX 3DL6A 1RX5A 4PTJA 1RX6A 3QG2A 3CD2A 3FQZA 2DHFA 3CLBA 1DR3A 3IRNA 2BLCA 3OAFA 2HM9A 1IA1A 3SGYA 4TU5X 2FZHA 5HT4A 4NX7A 2CIGA 3JWCA 1DREA 3CSEA 4KAKA 1DG5A 3NRRA 3EEMA 2XW7A 3Q1HA 3GI2A 3QGTA 3QLYA 3QLXA 1S3WA 1S3VA 3NXYA 2W3AA 1JOMA 4DFRA 4FHBA 5HI6A 1RC4A 4EIZA 4FGHA 3QLWA 1IA4A 4X5FA 3DG8A 4X5HA 1JOLA 1DYHA 3IA5A 3K47A 3TQ8A 4P68A 3FQCA 3JWMA 1RX1A 3F8ZA 1RA9A 4G95A 3EX8A 1U70A 3FQOA 3SRWX 2OBCA 3NZDA 1OHJA 1RB3A 4ECKA 1IA2A 4KM2A 3FRFX 1DISA 1DLSA 5HSUA 4XRBA 3SH2A 4LAHX 5HUIA 3SAIA 1D1GA 1YHOA 2BLBA 4IXED 3EELA 5HSRA 3EEKA 1RX3A 4HOFA 3QYOA 1J3IA 1DYIA 1RD7A 5EAJA 4KNEA 4XT5A 3TQBA 3GHWA 3JWKA 3M09A 2BL9A 4PSTA 1AO8A 4NX6A 4HOGA 2QK8A 2OIPA 3NTZA 2DRCA 4XT4A 4KYAA 4H98A 2FZIA 3QLRA 2GD9A 4Q6AA 1SEJA 5HPBA 4DPDA 1DRFA 3KJSA 4ELFA 3INVA 6DFRA 4M6JA 3UM5A 3R33A 3QLSA 3JVXA 4QLFA 3ROAA 2W9TA 3L3RA 4XE6X 3DFRA 1BZFA 4P3QA 4DPHA 5HQZA 4KY8A 2P4GA 1QZFA 3K45A 1DIUA 1M79A 1BOZA 1DHJA 1IA3A 3SR5X 1LUDA 3QL3A 4KJJA 3E0BA 4HOEA 3F0VX 2ITHA 4XT6A 5HVBA 5FDAA 3EEJA 3LG4A 4EIGA 4LEKX 3JW5A 4X5JA 5ECCA
chains in the Genus database with same CATH superfamily
4EJ1A 1DHFA 5HT5A 3OCHA 3SQYX 1U71A 4ELHA 3I8AX 1DAJA 1DR1A 1CD2A 4Q0DA 1RX8A 2D5NA 4PSSA 3QYLA 2LF1A 3S7AA 4IXFX 5DFRA 4ELGA 4X5IA 3SRUX 1DYJA 4QLEA 1DR7A 1RA8A 1DR4A 4HA9A 2BLAA 2ANQA 3NZCX 1S3YA 1DR2A 1CZ3A 3N0HA 3NZ9X 2G6VA 4KBNA 1M78A 1KLKA 3S9UA 1LY3A 3CL9A 1HFQA 3DRCA 1RH3A 5HQYA 1DF7A 3S3VA 3NZ6X 3GHCA 1DG8A 5U27A 3DL5A 2H2QA 3JTWA 1AOEA 7DFRA 1DDSA 1HFRA 1RX7A 1DRHA 2B3ZA 4M7UA 3F0UX 4ELBA 3GYFA 3TQ9A 4HA7A 1AI9A 4H96A 3JW3A 4OR7A 1MVTA 2INQA 3RG9A 3QL0A 4I1NA 4H95A 3NXRA 3JSUA 4QJCA 3FREX 4KL9A 1DRAA 1E26A 3FY8X 3SRSX 3M08A 1ZDRA 1RG7A 4XECX 2KGKA 4P66A 4ELEA 3QFXA 3KJRA 5ECXA 3RO9A 4PDJA 4M7VA 4QI9A 1RF7A 3FRAX 4M6KA 3NXTA 4EILA 1RA1A 4XT8A 4LAEX 1PDBA 1DR6A 1RE7A 3NXXA 1RA2A 2L28A 2W3MA 1RX2A 1J3KA 1OHKA 5JG0X 4P3RA 1HFPA 2AZNA 3F8YA 4Q0EA 5HF2X 3FRBX 1RB2A 1JUVA 3IA4A 3GHVA 3SA2A 3F0BX 3FL9A 4DDRA 1KMSA 3SRRX 1U72A 1PD8A 3NU0A 1DG7A 4G3MA 4LAGX 2W3WA 3F91A 5DXVA 4QJZD 4GH8A 4QHVA 8DFRA 5JA3A 4X5GA 2JYBA 2W9GA 2W3BA 2HXVA 3FRDX 4PSYA 3TD8A 4IXGX 3FS6A 3I3RA 5CCCA 3D84X 1PD9A 3FYVX 3JWFA 5CC9A 4KM0A 5U26A 2W9SA 4KJKA 3F0XX 3NZBX 3KFYA 3FL8A 3IROA 4KEBA 3FY9X 4H97A 1DR5A 3HJ3A 1RX4A 2O7PA 3TQAA 1MVSA 3K2HA 3F0QX 5HVEA 4DP3A 3NZAX 5HF0X 1DYRA 3K74A 2ANOA 3QLZA 4PTHA 2FZJA 2ZZAA 4G8ZX 3FQVA 4KJLA 4M6LA 3UM6A 1DLRA 1VJ3A 3KGYA 2CD2A 2W9HA 3EIGA 1M7AA 4I13A 1DHIA 3UM8A 3NXVA 4QLGA 3ZPCA 1VDRA 2HQPA 3DATA 4FGGA 3FQ0A 3IX9A 4KFJA 3D80A 3VCOA 1LY4A 1DRBA 3ZPGA 1TDRA 3FYWX 4OSGA 2D0KA 1DDRA 3NXOA 3DGAA 3FQFA 2W3VA 3DAUA 3F0SX 4Q67A 5E8QA 4KD7A 1RX9A 3SA1A 1J3JA 4M2XA 4XT7A 3IRMA 3HBBA 1RA3A 4CD2A 1S3UA 4KY4A 4KLXA 4RGCA 3KY8A 2C2SA 2C2TA 1KMVA 3SRQX 3DL6A 1RX5A 4PTJA 1RX6A 3QG2A 3CD2A 3FQZA 2DHFA 3CLBA 1DR3A 3IRNA 2BLCA 3OAFA 2HM9A 1IA1A 3SGYA 4TU5X 2FZHA 5HT4A 4NX7A 2CIGA 3JWCA 1DREA 3CSEA 4KAKA 1DG5A 3NRRA 3EEMA 2XW7A 3Q1HA 3GI2A 3QGTA 3QLYA 3QLXA 1S3WA 1S3VA 3NXYA 2W3AA 1JOMA 4DFRA 4FHBA 5HI6A 1RC4A 4EIZA 4FGHA 3QLWA 1IA4A 4X5FA 3DG8A 4X5HA 1JOLA 1DYHA 3IA5A 3K47A 3TQ8A 4P68A 3FQCA 3JWMA 1RX1A 3F8ZA 1RA9A 4G95A 3EX8A 1U70A 3FQOA 3SRWX 2OBCA 3NZDA 1OHJA 1RB3A 4ECKA 1IA2A 4KM2A 3FRFX 1DISA 1DLSA 5HSUA 4XRBA 3SH2A 4LAHX 5HUIA 3SAIA 1D1GA 1YHOA 2BLBA 4IXED 3EELA 5HSRA 3EEKA 1RX3A 4HOFA 3QYOA 1J3IA 1DYIA 1RD7A 5EAJA 4KNEA 4XT5A 3TQBA 3GHWA 3JWKA 3M09A 2BL9A 4PSTA 1AO8A 4NX6A 4HOGA 2QK8A 2OIPA 3NTZA 2DRCA 4XT4A 4KYAA 4H98A 2FZIA 3QLRA 2GD9A 4Q6AA 1SEJA 5HPBA 4DPDA 1DRFA 3KJSA 4ELFA 3INVA 6DFRA 4M6JA 3UM5A 3R33A 3QLSA 3JVXA 4QLFA 3ROAA 2W9TA 3L3RA 4XE6X 3DFRA 1BZFA 4P3QA 4DPHA 5HQZA 4KY8A 2P4GA 1QZFA 3K45A 1DIUA 1M79A 1BOZA 1DHJA 1IA3A 3SR5X 1LUDA 3QL3A 4KJJA 3E0BA 4HOEA 3F0VX 2ITHA 4XT6A 5HVBA 5FDAA 3EEJA 3LG4A 4EIGA 4LEKX 3JW5A 4X5JA 5ECCA
chains in the Genus database with same CATH topology
4EJ1A 1DHFA 5HT5A 3OCHA 3SQYX 1U71A 4ELHA 3I8AX 1DAJA 1DR1A 1CD2A 4Q0DA 1RX8A 2D5NA 4PSSA 3QYLA 2LF1A 3S7AA 4IXFX 5DFRA 4ELGA 4X5IA 3SRUX 1DYJA 4QLEA 1DR7A 1RA8A 1DR4A 4HA9A 2BLAA 2ANQA 3NZCX 1S3YA 1DR2A 1CZ3A 3N0HA 3NZ9X 2G6VA 4KBNA 1M78A 1KLKA 3S9UA 1LY3A 3CL9A 1HFQA 3DRCA 1RH3A 5HQYA 1DF7A 3S3VA 3NZ6X 3GHCA 1DG8A 5U27A 3DL5A 2H2QA 3JTWA 1AOEA 7DFRA 1DDSA 1HFRA 1RX7A 1DRHA 2B3ZA 4M7UA 3F0UX 4ELBA 3GYFA 3TQ9A 4HA7A 1AI9A 4H96A 3JW3A 4OR7A 1MVTA 2INQA 3RG9A 3QL0A 4I1NA 4H95A 3NXRA 3JSUA 4QJCA 3FREX 4KL9A 1DRAA 1E26A 3FY8X 3SRSX 3M08A 1ZDRA 1RG7A 4XECX 2KGKA 4P66A 4ELEA 3QFXA 3KJRA 5ECXA 3RO9A 4PDJA 4M7VA 4QI9A 1RF7A 3FRAX 4M6KA 3NXTA 4EILA 1RA1A 4XT8A 4LAEX 1PDBA 1DR6A 1RE7A 3NXXA 1RA2A 2L28A 2W3MA 1RX2A 1J3KA 1OHKA 5JG0X 4P3RA 1HFPA 2AZNA 3F8YA 4Q0EA 5HF2X 3FRBX 1RB2A 1JUVA 3IA4A 3GHVA 3SA2A 3F0BX 3FL9A 4DDRA 1KMSA 3SRRX 1U72A 1PD8A 3NU0A 1DG7A 4G3MA 4LAGX 2W3WA 3F91A 5DXVA 4QJZD 4GH8A 4QHVA 8DFRA 5JA3A 4X5GA 2JYBA 2W9GA 2W3BA 2HXVA 3FRDX 4PSYA 3TD8A 4IXGX 3FS6A 3I3RA 5CCCA 3D84X 1PD9A 3FYVX 3JWFA 5CC9A 4KM0A 5U26A 2W9SA 4KJKA 3F0XX 3NZBX 3KFYA 3FL8A 3IROA 4KEBA 3FY9X 4H97A 1DR5A 3HJ3A 1RX4A 2O7PA 3TQAA 1MVSA 3K2HA 3F0QX 5HVEA 4DP3A 3NZAX 5HF0X 1DYRA 3K74A 2ANOA 3QLZA 4PTHA 2FZJA 2ZZAA 4G8ZX 3FQVA 4KJLA 4M6LA 3UM6A 1DLRA 1VJ3A 3KGYA 2CD2A 2W9HA 3EIGA 1M7AA 4I13A 1DHIA 3UM8A 3NXVA 4QLGA 3ZPCA 1VDRA 2HQPA 3DATA 4FGGA 3FQ0A 3IX9A 4KFJA 3D80A 3VCOA 1LY4A 1DRBA 3ZPGA 1TDRA 3FYWX 4OSGA 2D0KA 1DDRA 3NXOA 3DGAA 3FQFA 2W3VA 3DAUA 3F0SX 4Q67A 5E8QA 4KD7A 1RX9A 3SA1A 1J3JA 4M2XA 4XT7A 3IRMA 3HBBA 1RA3A 4CD2A 1S3UA 4KY4A 4KLXA 4RGCA 3KY8A 2C2SA 2C2TA 1KMVA 3SRQX 3DL6A 1RX5A 4PTJA 1RX6A 3QG2A 3CD2A 3FQZA 2DHFA 3CLBA 1DR3A 3IRNA 2BLCA 3OAFA 2HM9A 1IA1A 3SGYA 4TU5X 2FZHA 5HT4A 4NX7A 2CIGA 3JWCA 1DREA 3CSEA 4KAKA 1DG5A 3NRRA 3EEMA 2XW7A 3Q1HA 3GI2A 3QGTA 3QLYA 3QLXA 1S3WA 1S3VA 3NXYA 2W3AA 1JOMA 4DFRA 4FHBA 5HI6A 1RC4A 4EIZA 4FGHA 3QLWA 1IA4A 4X5FA 3DG8A 4X5HA 1JOLA 1DYHA 3IA5A 3K47A 3TQ8A 4P68A 3FQCA 3JWMA 1RX1A 3F8ZA 1RA9A 4G95A 3EX8A 1U70A 3FQOA 3SRWX 2OBCA 3NZDA 1OHJA 1RB3A 4ECKA 1IA2A 4KM2A 3FRFX 1DISA 1DLSA 5HSUA 4XRBA 3SH2A 4LAHX 5HUIA 3SAIA 1D1GA 1YHOA 2BLBA 4IXED 3EELA 5HSRA 3EEKA 1RX3A 4HOFA 3QYOA 1J3IA 1DYIA 1RD7A 5EAJA 4KNEA 4XT5A 3TQBA 3GHWA 3JWKA 3M09A 2BL9A 4PSTA 1AO8A 4NX6A 4HOGA 2QK8A 2OIPA 3NTZA 2DRCA 4XT4A 4KYAA 4H98A 2FZIA 3QLRA 2GD9A 4Q6AA 1SEJA 5HPBA 4DPDA 1DRFA 3KJSA 4ELFA 3INVA 6DFRA 4M6JA 3UM5A 3R33A 3QLSA 3JVXA 4QLFA 3ROAA 2W9TA 3L3RA 4XE6X 3DFRA 1BZFA 4P3QA 4DPHA 5HQZA 4KY8A 2P4GA 1QZFA 3K45A 1DIUA 1M79A 1BOZA 1DHJA 1IA3A 3SR5X 1LUDA 3QL3A 4KJJA 3E0BA 4HOEA 3F0VX 2ITHA 4XT6A 5HVBA 5FDAA 3EEJA 3LG4A 4EIGA 4LEKX 3JW5A 4X5JA 5ECCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EJ1 A;  1DHF A;  5HT5 A;  3OCH A;  3SQY X;  1U71 A;  4ELH A;  3I8A X;  1DAJ A;  1DR1 A;  1CD2 A;  4Q0D A;  1RX8 A;  2D5N A;  4PSS A;  3QYL A;  2LF1 A;  3S7A A;  4IXF X;  5DFR A;  4ELG A;  4X5I A;  3SRU X;  1DYJ A;  4QLE A;  1DR7 A;  1RA8 A;  1DR4 A;  4HA9 A;  2BLA A;  2ANQ A;  3NZC X;  1S3Y A;  1DR2 A;  1CZ3 A;  3N0H A;  3NZ9 X;  2G6V A;  4KBN A;  1M78 A;  1KLK A;  3S9U A;  1LY3 A;  3CL9 A;  1HFQ A;  3DRC A;  1RH3 A;  5HQY A;  1DF7 A;  3S3V A;  3NZ6 X;  3GHC A;  1DG8 A;  5U27 A;  3DL5 A;  2H2Q A;  3JTW A;  1AOE A;  7DFR A;  1DDS A;  1HFR A;  1RX7 A;  1DRH A;  2B3Z A;  4M7U A;  3F0U X;  4ELB A;  3GYF A;  3TQ9 A;  4HA7 A;  1AI9 A;  4H96 A;  3JW3 A;  4OR7 A;  1MVT A;  2INQ A;  3RG9 A;  3QL0 A;  4I1N A;  4H95 A;  3NXR A;  3JSU A;  4QJC A;  3FRE X;  4KL9 A;  1DRA A;  1E26 A;  3FY8 X;  3SRS X;  3M08 A;  1ZDR A;  1RG7 A;  4XEC X;  2KGK A;  4P66 A;  4ELE A;  3QFX A;  3KJR A;  5ECX A;  3RO9 A;  4PDJ A;  4M7V A;  4QI9 A;  1RF7 A;  3FRA X;  4M6K A;  3NXT A;  4EIL A;  1RA1 A;  4XT8 A;  4LAE X;  1PDB A;  1DR6 A;  1RE7 A;  3NXX A;  1RA2 A;  2L28 A;  2W3M A;  1RX2 A;  1J3K A;  1OHK A;  5JG0 X;  4P3R A;  1HFP A;  2AZN A;  3F8Y A;  4Q0E A;  5HF2 X;  3FRB X;  1RB2 A;  1JUV A;  3IA4 A;  3GHV A;  3SA2 A;  3F0B X;  3FL9 A;  4DDR A;  1KMS A;  3SRR X;  1U72 A;  1PD8 A;  3NU0 A;  1DG7 A;  4G3M A;  4LAG X;  2W3W A;  3F91 A;  5DXV A;  4QJZ D;  4GH8 A;  4QHV A;  8DFR A;  5JA3 A;  4X5G A;  2JYB A;  2W9G A;  2W3B A;  2HXV A;  3FRD X;  4PSY A;  3TD8 A;  4IXG X;  3FS6 A;  3I3R A;  5CCC A;  3D84 X;  1PD9 A;  3FYV X;  3JWF A;  5CC9 A;  4KM0 A;  5U26 A;  2W9S A;  4KJK A;  3F0X X;  3NZB X;  3KFY A;  3FL8 A;  3IRO A;  4KEB A;  3FY9 X;  4H97 A;  1DR5 A;  3HJ3 A;  1RX4 A;  2O7P A;  3TQA A;  1MVS A;  3K2H A;  3F0Q X;  5HVE A;  4DP3 A;  3NZA X;  5HF0 X;  1DYR A;  3K74 A;  2ANO A;  3QLZ A;  4PTH A;  2FZJ A;  2ZZA A;  4G8Z X;  3FQV A;  4KJL A;  4M6L A;  3UM6 A;  1DLR A;  1VJ3 A;  3KGY A;  2CD2 A;  2W9H A;  3EIG A;  1M7A A;  4I13 A;  1DHI A;  3UM8 A;  3NXV A;  4QLG A;  3ZPC A;  1VDR A;  2HQP A;  3DAT A;  4FGG A;  3FQ0 A;  3IX9 A;  4KFJ A;  3D80 A;  3VCO A;  1LY4 A;  1DRB A;  3ZPG A;  1TDR A;  3FYW X;  4OSG A;  2D0K A;  1DDR A;  3NXO A;  3DGA A;  3FQF A;  2W3V A;  3DAU A;  3F0S X;  4Q67 A;  5E8Q A;  4KD7 A;  1RX9 A;  3SA1 A;  1J3J A;  4M2X A;  4XT7 A;  3IRM A;  3HBB A;  1RA3 A;  4CD2 A;  1S3U A;  4KY4 A;  4KLX A;  4RGC A;  3KY8 A;  2C2S A;  2C2T A;  1KMV A;  3SRQ X;  3DL6 A;  1RX5 A;  4PTJ A;  1RX6 A;  3QG2 A;  3CD2 A;  3FQZ A;  2DHF A;  3CLB A;  1DR3 A;  3IRN A;  2BLC A;  3OAF A;  2HM9 A;  1IA1 A;  3SGY A;  4TU5 X;  2FZH A;  5HT4 A;  4NX7 A;  2CIG A;  3JWC A;  1DRE A;  3CSE A;  4KAK A;  1DG5 A;  3NRR A;  3EEM A;  2XW7 A;  3Q1H A;  3GI2 A;  3QGT A;  3QLY A;  3QLX A;  1S3W A;  1S3V A;  3NXY A;  2W3A A;  1JOM A;  4DFR A;  4FHB A;  5HI6 A;  1RC4 A;  4EIZ A;  4FGH A;  3QLW A;  1IA4 A;  4X5F A;  3DG8 A;  4X5H A;  1JOL A;  1DYH A;  3IA5 A;  3K47 A;  3TQ8 A;  4P68 A;  3FQC A;  3JWM A;  1RX1 A;  3F8Z A;  1RA9 A;  4G95 A;  3EX8 A;  1U70 A;  3FQO A;  3SRW X;  2OBC A;  3NZD A;  1OHJ A;  1RB3 A;  4ECK A;  1IA2 A;  4KM2 A;  3FRF X;  1DIS A;  1DLS A;  5HSU A;  4XRB A;  3SH2 A;  4LAH X;  5HUI A;  3SAI A;  1D1G A;  1YHO A;  2BLB A;  4IXE D;  3EEL A;  5HSR A;  3EEK A;  1RX3 A;  4HOF A;  3QYO A;  1J3I A;  1DYI A;  1RD7 A;  5EAJ A;  4KNE A;  4XT5 A;  3TQB A;  3GHW A;  3JWK A;  3M09 A;  2BL9 A;  4PST A;  1AO8 A;  4NX6 A;  4HOG A;  2QK8 A;  2OIP A;  3NTZ A;  2DRC A;  4XT4 A;  4KYA A;  4H98 A;  2FZI A;  3QLR A;  2GD9 A;  4Q6A A;  1SEJ A;  5HPB A;  4DPD A;  1DRF A;  3KJS A;  4ELF A;  3INV A;  6DFR A;  4M6J A;  3UM5 A;  3R33 A;  3QLS A;  3JVX A;  4QLF A;  3ROA A;  2W9T A;  3L3R A;  4XE6 X;  3DFR A;  1BZF A;  4P3Q A;  4DPH A;  5HQZ A;  4KY8 A;  2P4G A;  1QZF A;  3K45 A;  1DIU A;  1M79 A;  1BOZ A;  1DHJ A;  1IA3 A;  3SR5 X;  1LUD A;  3QL3 A;  4KJJ A;  3E0B A;  4HOE A;  3F0V X;  2ITH A;  4XT6 A;  5HVB A;  5FDA A;  3EEJ A;  3LG4 A;  4EIG A;  4LEK X;  3JW5 A;  4X5J A;  5ECC A; 
#chains in the Genus database with same CATH topology
 4EJ1 A;  1DHF A;  5HT5 A;  3OCH A;  3SQY X;  1U71 A;  4ELH A;  3I8A X;  1DAJ A;  1DR1 A;  1CD2 A;  4Q0D A;  1RX8 A;  2D5N A;  4PSS A;  3QYL A;  2LF1 A;  3S7A A;  4IXF X;  5DFR A;  4ELG A;  4X5I A;  3SRU X;  1DYJ A;  4QLE A;  1DR7 A;  1RA8 A;  1DR4 A;  4HA9 A;  2BLA A;  2ANQ A;  3NZC X;  1S3Y A;  1DR2 A;  1CZ3 A;  3N0H A;  3NZ9 X;  2G6V A;  4KBN A;  1M78 A;  1KLK A;  3S9U A;  1LY3 A;  3CL9 A;  1HFQ A;  3DRC A;  1RH3 A;  5HQY A;  1DF7 A;  3S3V A;  3NZ6 X;  3GHC A;  1DG8 A;  5U27 A;  3DL5 A;  2H2Q A;  3JTW A;  1AOE A;  7DFR A;  1DDS A;  1HFR A;  1RX7 A;  1DRH A;  2B3Z A;  4M7U A;  3F0U X;  4ELB A;  3GYF A;  3TQ9 A;  4HA7 A;  1AI9 A;  4H96 A;  3JW3 A;  4OR7 A;  1MVT A;  2INQ A;  3RG9 A;  3QL0 A;  4I1N A;  4H95 A;  3NXR A;  3JSU A;  4QJC A;  3FRE X;  4KL9 A;  1DRA A;  1E26 A;  3FY8 X;  3SRS X;  3M08 A;  1ZDR A;  1RG7 A;  4XEC X;  2KGK A;  4P66 A;  4ELE A;  3QFX A;  3KJR A;  5ECX A;  3RO9 A;  4PDJ A;  4M7V A;  4QI9 A;  1RF7 A;  3FRA X;  4M6K A;  3NXT A;  4EIL A;  1RA1 A;  4XT8 A;  4LAE X;  1PDB A;  1DR6 A;  1RE7 A;  3NXX A;  1RA2 A;  2L28 A;  2W3M A;  1RX2 A;  1J3K A;  1OHK A;  5JG0 X;  4P3R A;  1HFP A;  2AZN A;  3F8Y A;  4Q0E A;  5HF2 X;  3FRB X;  1RB2 A;  1JUV A;  3IA4 A;  3GHV A;  3SA2 A;  3F0B X;  3FL9 A;  4DDR A;  1KMS A;  3SRR X;  1U72 A;  1PD8 A;  3NU0 A;  1DG7 A;  4G3M A;  4LAG X;  2W3W A;  3F91 A;  5DXV A;  4QJZ D;  4GH8 A;  4QHV A;  8DFR A;  5JA3 A;  4X5G A;  2JYB A;  2W9G A;  2W3B A;  2HXV A;  3FRD X;  4PSY A;  3TD8 A;  4IXG X;  3FS6 A;  3I3R A;  5CCC A;  3D84 X;  1PD9 A;  3FYV X;  3JWF A;  5CC9 A;  4KM0 A;  5U26 A;  2W9S A;  4KJK A;  3F0X X;  3NZB X;  3KFY A;  3FL8 A;  3IRO A;  4KEB A;  3FY9 X;  4H97 A;  1DR5 A;  3HJ3 A;  1RX4 A;  2O7P A;  3TQA A;  1MVS A;  3K2H A;  3F0Q X;  5HVE A;  4DP3 A;  3NZA X;  5HF0 X;  1DYR A;  3K74 A;  2ANO A;  3QLZ A;  4PTH A;  2FZJ A;  2ZZA A;  4G8Z X;  3FQV A;  4KJL A;  4M6L A;  3UM6 A;  1DLR A;  1VJ3 A;  3KGY A;  2CD2 A;  2W9H A;  3EIG A;  1M7A A;  4I13 A;  1DHI A;  3UM8 A;  3NXV A;  4QLG A;  3ZPC A;  1VDR A;  2HQP A;  3DAT A;  4FGG A;  3FQ0 A;  3IX9 A;  4KFJ A;  3D80 A;  3VCO A;  1LY4 A;  1DRB A;  3ZPG A;  1TDR A;  3FYW X;  4OSG A;  2D0K A;  1DDR A;  3NXO A;  3DGA A;  3FQF A;  2W3V A;  3DAU A;  3F0S X;  4Q67 A;  5E8Q A;  4KD7 A;  1RX9 A;  3SA1 A;  1J3J A;  4M2X A;  4XT7 A;  3IRM A;  3HBB A;  1RA3 A;  4CD2 A;  1S3U A;  4KY4 A;  4KLX A;  4RGC A;  3KY8 A;  2C2S A;  2C2T A;  1KMV A;  3SRQ X;  3DL6 A;  1RX5 A;  4PTJ A;  1RX6 A;  3QG2 A;  3CD2 A;  3FQZ A;  2DHF A;  3CLB A;  1DR3 A;  3IRN A;  2BLC A;  3OAF A;  2HM9 A;  1IA1 A;  3SGY A;  4TU5 X;  2FZH A;  5HT4 A;  4NX7 A;  2CIG A;  3JWC A;  1DRE A;  3CSE A;  4KAK A;  1DG5 A;  3NRR A;  3EEM A;  2XW7 A;  3Q1H A;  3GI2 A;  3QGT A;  3QLY A;  3QLX A;  1S3W A;  1S3V A;  3NXY A;  2W3A A;  1JOM A;  4DFR A;  4FHB A;  5HI6 A;  1RC4 A;  4EIZ A;  4FGH A;  3QLW A;  1IA4 A;  4X5F A;  3DG8 A;  4X5H A;  1JOL A;  1DYH A;  3IA5 A;  3K47 A;  3TQ8 A;  4P68 A;  3FQC A;  3JWM A;  1RX1 A;  3F8Z A;  1RA9 A;  4G95 A;  3EX8 A;  1U70 A;  3FQO A;  3SRW X;  2OBC A;  3NZD A;  1OHJ A;  1RB3 A;  4ECK A;  1IA2 A;  4KM2 A;  3FRF X;  1DIS A;  1DLS A;  5HSU A;  4XRB A;  3SH2 A;  4LAH X;  5HUI A;  3SAI A;  1D1G A;  1YHO A;  2BLB A;  4IXE D;  3EEL A;  5HSR A;  3EEK A;  1RX3 A;  4HOF A;  3QYO A;  1J3I A;  1DYI A;  1RD7 A;  5EAJ A;  4KNE A;  4XT5 A;  3TQB A;  3GHW A;  3JWK A;  3M09 A;  2BL9 A;  4PST A;  1AO8 A;  4NX6 A;  4HOG A;  2QK8 A;  2OIP A;  3NTZ A;  2DRC A;  4XT4 A;  4KYA A;  4H98 A;  2FZI A;  3QLR A;  2GD9 A;  4Q6A A;  1SEJ A;  5HPB A;  4DPD A;  1DRF A;  3KJS A;  4ELF A;  3INV A;  6DFR A;  4M6J A;  3UM5 A;  3R33 A;  3QLS A;  3JVX A;  4QLF A;  3ROA A;  2W9T A;  3L3R A;  4XE6 X;  3DFR A;  1BZF A;  4P3Q A;  4DPH A;  5HQZ A;  4KY8 A;  2P4G A;  1QZF A;  3K45 A;  1DIU A;  1M79 A;  1BOZ A;  1DHJ A;  1IA3 A;  3SR5 X;  1LUD A;  3QL3 A;  4KJJ A;  3E0B A;  4HOE A;  3F0V X;  2ITH A;  4XT6 A;  5HVB A;  5FDA A;  3EEJ A;  3LG4 A;  4EIG A;  4LEK X;  3JW5 A;  4X5J A;  5ECC A; 
#chains in the Genus database with same CATH homology
 4EJ1 A;  1DHF A;  5HT5 A;  3OCH A;  3SQY X;  1U71 A;  4ELH A;  3I8A X;  1DAJ A;  1DR1 A;  1CD2 A;  4Q0D A;  1RX8 A;  2D5N A;  4PSS A;  3QYL A;  2LF1 A;  3S7A A;  4IXF X;  5DFR A;  4ELG A;  4X5I A;  3SRU X;  1DYJ A;  4QLE A;  1DR7 A;  1RA8 A;  1DR4 A;  4HA9 A;  2BLA A;  2ANQ A;  3NZC X;  1S3Y A;  1DR2 A;  1CZ3 A;  3N0H A;  3NZ9 X;  2G6V A;  4KBN A;  1M78 A;  1KLK A;  3S9U A;  1LY3 A;  3CL9 A;  1HFQ A;  3DRC A;  1RH3 A;  5HQY A;  1DF7 A;  3S3V A;  3NZ6 X;  3GHC A;  1DG8 A;  5U27 A;  3DL5 A;  2H2Q A;  3JTW A;  1AOE A;  7DFR A;  1DDS A;  1HFR A;  1RX7 A;  1DRH A;  2B3Z A;  4M7U A;  3F0U X;  4ELB A;  3GYF A;  3TQ9 A;  4HA7 A;  1AI9 A;  4H96 A;  3JW3 A;  4OR7 A;  1MVT A;  2INQ A;  3RG9 A;  3QL0 A;  4I1N A;  4H95 A;  3NXR A;  3JSU A;  4QJC A;  3FRE X;  4KL9 A;  1DRA A;  1E26 A;  3FY8 X;  3SRS X;  3M08 A;  1ZDR A;  1RG7 A;  4XEC X;  2KGK A;  4P66 A;  4ELE A;  3QFX A;  3KJR A;  5ECX A;  3RO9 A;  4PDJ A;  4M7V A;  4QI9 A;  1RF7 A;  3FRA X;  4M6K A;  3NXT A;  4EIL A;  1RA1 A;  4XT8 A;  4LAE X;  1PDB A;  1DR6 A;  1RE7 A;  3NXX A;  1RA2 A;  2L28 A;  2W3M A;  1RX2 A;  1J3K A;  1OHK A;  5JG0 X;  4P3R A;  1HFP A;  2AZN A;  3F8Y A;  4Q0E A;  5HF2 X;  3FRB X;  1RB2 A;  1JUV A;  3IA4 A;  3GHV A;  3SA2 A;  3F0B X;  3FL9 A;  4DDR A;  1KMS A;  3SRR X;  1U72 A;  1PD8 A;  3NU0 A;  1DG7 A;  4G3M A;  4LAG X;  2W3W A;  3F91 A;  5DXV A;  4QJZ D;  4GH8 A;  4QHV A;  8DFR A;  5JA3 A;  4X5G A;  2JYB A;  2W9G A;  2W3B A;  2HXV A;  3FRD X;  4PSY A;  3TD8 A;  4IXG X;  3FS6 A;  3I3R A;  5CCC A;  3D84 X;  1PD9 A;  3FYV X;  3JWF A;  5CC9 A;  4KM0 A;  5U26 A;  2W9S A;  4KJK A;  3F0X X;  3NZB X;  3KFY A;  3FL8 A;  3IRO A;  4KEB A;  3FY9 X;  4H97 A;  1DR5 A;  3HJ3 A;  1RX4 A;  2O7P A;  3TQA A;  1MVS A;  3K2H A;  3F0Q X;  5HVE A;  4DP3 A;  3NZA X;  5HF0 X;  1DYR A;  3K74 A;  2ANO A;  3QLZ A;  4PTH A;  2FZJ A;  2ZZA A;  4G8Z X;  3FQV A;  4KJL A;  4M6L A;  3UM6 A;  1DLR A;  1VJ3 A;  3KGY A;  2CD2 A;  2W9H A;  3EIG A;  1M7A A;  4I13 A;  1DHI A;  3UM8 A;  3NXV A;  4QLG A;  3ZPC A;  1VDR A;  2HQP A;  3DAT A;  4FGG A;  3FQ0 A;  3IX9 A;  4KFJ A;  3D80 A;  3VCO A;  1LY4 A;  1DRB A;  3ZPG A;  1TDR A;  3FYW X;  4OSG A;  2D0K A;  1DDR A;  3NXO A;  3DGA A;  3FQF A;  2W3V A;  3DAU A;  3F0S X;  4Q67 A;  5E8Q A;  4KD7 A;  1RX9 A;  3SA1 A;  1J3J A;  4M2X A;  4XT7 A;  3IRM A;  3HBB A;  1RA3 A;  4CD2 A;  1S3U A;  4KY4 A;  4KLX A;  4RGC A;  3KY8 A;  2C2S A;  2C2T A;  1KMV A;  3SRQ X;  3DL6 A;  1RX5 A;  4PTJ A;  1RX6 A;  3QG2 A;  3CD2 A;  3FQZ A;  2DHF A;  3CLB A;  1DR3 A;  3IRN A;  2BLC A;  3OAF A;  2HM9 A;  1IA1 A;  3SGY A;  4TU5 X;  2FZH A;  5HT4 A;  4NX7 A;  2CIG A;  3JWC A;  1DRE A;  3CSE A;  4KAK A;  1DG5 A;  3NRR A;  3EEM A;  2XW7 A;  3Q1H A;  3GI2 A;  3QGT A;  3QLY A;  3QLX A;  1S3W A;  1S3V A;  3NXY A;  2W3A A;  1JOM A;  4DFR A;  4FHB A;  5HI6 A;  1RC4 A;  4EIZ A;  4FGH A;  3QLW A;  1IA4 A;  4X5F A;  3DG8 A;  4X5H A;  1JOL A;  1DYH A;  3IA5 A;  3K47 A;  3TQ8 A;  4P68 A;  3FQC A;  3JWM A;  1RX1 A;  3F8Z A;  1RA9 A;  4G95 A;  3EX8 A;  1U70 A;  3FQO A;  3SRW X;  2OBC A;  3NZD A;  1OHJ A;  1RB3 A;  4ECK A;  1IA2 A;  4KM2 A;  3FRF X;  1DIS A;  1DLS A;  5HSU A;  4XRB A;  3SH2 A;  4LAH X;  5HUI A;  3SAI A;  1D1G A;  1YHO A;  2BLB A;  4IXE D;  3EEL A;  5HSR A;  3EEK A;  1RX3 A;  4HOF A;  3QYO A;  1J3I A;  1DYI A;  1RD7 A;  5EAJ A;  4KNE A;  4XT5 A;  3TQB A;  3GHW A;  3JWK A;  3M09 A;  2BL9 A;  4PST A;  1AO8 A;  4NX6 A;  4HOG A;  2QK8 A;  2OIP A;  3NTZ A;  2DRC A;  4XT4 A;  4KYA A;  4H98 A;  2FZI A;  3QLR A;  2GD9 A;  4Q6A A;  1SEJ A;  5HPB A;  4DPD A;  1DRF A;  3KJS A;  4ELF A;  3INV A;  6DFR A;  4M6J A;  3UM5 A;  3R33 A;  3QLS A;  3JVX A;  4QLF A;  3ROA A;  2W9T A;  3L3R A;  4XE6 X;  3DFR A;  1BZF A;  4P3Q A;  4DPH A;  5HQZ A;  4KY8 A;  2P4G A;  1QZF A;  3K45 A;  1DIU A;  1M79 A;  1BOZ A;  1DHJ A;  1IA3 A;  3SR5 X;  1LUD A;  3QL3 A;  4KJJ A;  3E0B A;  4HOE A;  3F0V X;  2ITH A;  4XT6 A;  5HVB A;  5FDA A;  3EEJ A;  3LG4 A;  4EIG A;  4LEK X;  3JW5 A;  4X5J A;  5ECC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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