5JA3A

Mycobacterium tuberculosis dihydrofolate reductase complexed with beta- nadph and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (ucp1106)
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
159
structure length
159
Chain Sequence
MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Mycobacterium tuberculosis
molecule keywords Dihydrofolate reductase
total genus 43
structure length 159
sequence length 159
chains with identical sequence B, C, D
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2016-04-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 5ja3A00
4KY8A 3FQ0A 3FRAX 3RO9A 3TQAA 1HFPA 3NXTA 4H96A 3FL8A 4KBNA 4EIZA 2BLBA 4QLEA 1CZ3A 3F0UX 3NZDA 4KLXA 1DF7A 1J3JA 5HVEA 4XT7A 5HQZA 4EILA 5HVBA 3DRCA 2DHFA 4FGHA 1RX6A 3FREX 4ELHA 1JOLA 3NTZA 1TDRA 3I8AX 4HA9A 3TD8A 3IA4A 3S3VA 5HSRA 2W3WA 1HFQA 3UM6A 4RGCA 2C2SA 3EELA 3IA5A 3JSUA 3QLWA 3NXOA 1HFRA 1S3VA 1DHJA 1RX3A 1BOZA 3Q1HA 5DFRA 5HSUA 2OIPA 5EAJA 4QI9A 2BLAA 4PTJA 4QLGA 1YHOA 2BL9A 4KL9A 3GI2A 3QLZA 2W9SA 1RC4A 1J3KA 3FRBX 4X5HA 2H2QA 5HQYA 3QFXA 3JVXA 4P68A 1PD8A 5JA3A 3S7AA 3IRMA 4XT5A 2CIGA 3SRRX 4XECX 3NU0A 2KGKA 3NZ6X 2D5NA 1RX2A 3RG9A 3GHCA 3F0XX 3OAFA 4Q67A 1IA3A 1DRBA 3NXYA 5U26A 4XT8A 3NXXA 1RG7A 1RX7A 3DL5A 1DRHA 2HXVA 3GHWA 3F8YA 4KYAA 1DG7A 4ELGA 4M7UA 1J3IA 1U70A 4DDRA 3SAIA 1PDBA 3KFYA 2INQA 4OSGA 3FYVX 1IA2A 1RB3A 1S3UA 3FRFX 3JWFA 4X5IA 3HJ3A 4Q0DA 4X5JA 4G8ZX 3GHVA 1RF7A 4PSTA 1AI9A 3M08A 3SQYX 3D84X 1LY3A 1RA1A 3NZAX 2FZJA 4FGGA 1RA3A 1DR5A 4M6JA 4PTHA 1LUDA 3EIGA 2D0KA 4QJZD 3QL0A 4GH8A 1RD7A 3FRDX 4H97A 5CC9A 2JYBA 2AZNA 3FQVA 4FHBA 5HF2X 2LF1A 3ROAA 4PDJA 4HA7A 3QLXA 5CCCA 4XE6X 1S3YA 2W9HA 1ZDRA 4HOEA 5HI6A 5FDAA 4KD7A 3F0VX 1DHFA 2ANOA 4NX7A 3EEJA 1MVTA 1OHJA 5DXVA 4LAGX 4ELEA 1D1GA 4Q0EA 1RB2A 4ECKA 3DGAA 1RX5A 3QL3A 1RX9A 1DIUA 4LAEX 4EJ1A 3SRQX 4DPHA 3L3RA 3NXRA 1JUVA 3SH2A 1U71A 3KJRA 1DLRA 3IX9A 4XRBA 1OHKA 3F8ZA 7DFRA 2FZIA 1DR4A 3JWKA 4KM0A 1DYRA 4G3MA 4M7VA 4KM2A 2O7PA 3INVA 1DR3A 3IRNA 4KNEA 1RX4A 4KJJA 2FZHA 1U72A 3JTWA 4DP3A 1DG5A 3EEKA 1VJ3A 4LEKX 5HUIA 3FL9A 1IA1A 2ITHA 3SR5X 8DFRA 1DREA 3OCHA 3JWCA 5HF0X 2W9GA 1MVSA 5ECCA 2W3AA 3GYFA 3FQCA 1M79A 4QJCA 1PD9A 3FS6A 3FY8X 4M6LA 3M09A 1AOEA 1DAJA 6DFRA 1DDSA 1DYJA 1KLKA 3R33A 3K74A 3QLYA 1VDRA 4P66A 1RA9A 4IXED 4M6KA 3VCOA 3K47A 1DDRA 4CD2A 3JWMA 3I3RA 4Q6AA 4IXFX 4G95A 2QK8A 1DR2A 1DYIA 1DR6A 1DLSA 4KAKA 1RX1A 4NX6A 4XT6A 2B3ZA 4TU5X 2ANQA 4QLFA 3LG4A 2HM9A 3F0BX 1RH3A 1M78A 3QLSA 3QLRA 3DL6A 1RE7A 3ZPCA 4KY4A 1IA4A 1DR7A 2OBCA 3UM5A 3ZPGA 3FQFA 1CD2A 3CD2A 1S3WA 3DFRA 1SEJA 3SA2A 3KY8A 3QYLA 5HT4A 2G6VA 2CD2A 3SA1A 4EIGA 2C2TA 3KJSA 4HOGA 1RX8A 3K2HA 4OR7A 4ELBA 3TQBA 1M7AA 3DAUA 5HT5A 4I13A 3K45A 4PSYA 3F91A 4LAHX 3SGYA 3NRRA 4M2XA 4DFRA 2BLCA 3D80A 4H98A 1AO8A 3FYWX 3KGYA 1KMVA 3NZ9X 2HQPA 4KEBA 1BZFA 2ZZAA 1RA2A 4XT4A 5U27A 3DG8A 1RA8A 3UM8A 5ECXA 3CL9A 3F0SX 3NZCX 3NXVA 2GD9A 3SRSX 3CLBA 3FQZA 3QYOA 3E0BA 3F0QX 2L28A 2P4GA 4DPDA 1DISA 3S9UA 3TQ8A 3IROA 2W3BA 4I1NA 4HOFA 4IXGX 3CSEA 4KJKA 4X5FA 1DYHA 4KFJA 4PSSA 1DRFA 3DATA 4KJLA 3TQ9A 4ELFA 3JW5A 3FY9X 1DHIA 2W3MA 3SRUX 1DRAA 3JW3A 2XW7A 1JOMA 1KMSA 2W9TA 3HBBA 4QHVA 4H95A 1DG8A 4P3RA 1QZFA 3QG2A 3N0HA 1DR1A 1E26A 3EEMA 5HPBA 2W3VA 5E8QA 3QGTA 1LY4A 2DRCA 5JG0X 3SRWX 4P3QA 4X5GA 3FQOA 3NZBX 3EX8A
chains in the Genus database with same CATH superfamily
4KY8A 3FQ0A 3FRAX 3RO9A 3TQAA 1HFPA 3NXTA 4H96A 3FL8A 4KBNA 4EIZA 2BLBA 4QLEA 1CZ3A 3F0UX 3NZDA 4KLXA 1DF7A 1J3JA 5HVEA 4XT7A 5HQZA 4EILA 5HVBA 3DRCA 2DHFA 4FGHA 1RX6A 3FREX 4ELHA 1JOLA 3NTZA 1TDRA 3I8AX 4HA9A 3TD8A 3IA4A 3S3VA 5HSRA 2W3WA 1HFQA 3UM6A 4RGCA 2C2SA 3EELA 3IA5A 3JSUA 3QLWA 3NXOA 1HFRA 1S3VA 1DHJA 1RX3A 1BOZA 3Q1HA 5DFRA 5HSUA 2OIPA 5EAJA 4QI9A 2BLAA 4PTJA 4QLGA 1YHOA 2BL9A 4KL9A 3GI2A 3QLZA 2W9SA 1RC4A 1J3KA 3FRBX 4X5HA 2H2QA 5HQYA 3QFXA 3JVXA 4P68A 1PD8A 5JA3A 3S7AA 3IRMA 4XT5A 2CIGA 3SRRX 4XECX 3NU0A 2KGKA 3NZ6X 2D5NA 1RX2A 3RG9A 3GHCA 3F0XX 3OAFA 4Q67A 1IA3A 1DRBA 3NXYA 5U26A 4XT8A 3NXXA 1RG7A 1RX7A 3DL5A 1DRHA 2HXVA 3GHWA 3F8YA 4KYAA 1DG7A 4ELGA 4M7UA 1J3IA 1U70A 4DDRA 3SAIA 1PDBA 3KFYA 2INQA 4OSGA 3FYVX 1IA2A 1RB3A 1S3UA 3FRFX 3JWFA 4X5IA 3HJ3A 4Q0DA 4X5JA 4G8ZX 3GHVA 1RF7A 4PSTA 1AI9A 3M08A 3SQYX 3D84X 1LY3A 1RA1A 3NZAX 2FZJA 4FGGA 1RA3A 1DR5A 4M6JA 4PTHA 1LUDA 3EIGA 2D0KA 4QJZD 3QL0A 4GH8A 1RD7A 3FRDX 4H97A 5CC9A 2JYBA 2AZNA 3FQVA 4FHBA 5HF2X 2LF1A 3ROAA 4PDJA 4HA7A 3QLXA 5CCCA 4XE6X 1S3YA 2W9HA 1ZDRA 4HOEA 5HI6A 5FDAA 4KD7A 3F0VX 1DHFA 2ANOA 4NX7A 3EEJA 1MVTA 1OHJA 5DXVA 4LAGX 4ELEA 1D1GA 4Q0EA 1RB2A 4ECKA 3DGAA 1RX5A 3QL3A 1RX9A 1DIUA 4LAEX 4EJ1A 3SRQX 4DPHA 3L3RA 3NXRA 1JUVA 3SH2A 1U71A 3KJRA 1DLRA 3IX9A 4XRBA 1OHKA 3F8ZA 7DFRA 2FZIA 1DR4A 3JWKA 4KM0A 1DYRA 4G3MA 4M7VA 4KM2A 2O7PA 3INVA 1DR3A 3IRNA 4KNEA 1RX4A 4KJJA 2FZHA 1U72A 3JTWA 4DP3A 1DG5A 3EEKA 1VJ3A 4LEKX 5HUIA 3FL9A 1IA1A 2ITHA 3SR5X 8DFRA 1DREA 3OCHA 3JWCA 5HF0X 2W9GA 1MVSA 5ECCA 2W3AA 3GYFA 3FQCA 1M79A 4QJCA 1PD9A 3FS6A 3FY8X 4M6LA 3M09A 1AOEA 1DAJA 6DFRA 1DDSA 1DYJA 1KLKA 3R33A 3K74A 3QLYA 1VDRA 4P66A 1RA9A 4IXED 4M6KA 3VCOA 3K47A 1DDRA 4CD2A 3JWMA 3I3RA 4Q6AA 4IXFX 4G95A 2QK8A 1DR2A 1DYIA 1DR6A 1DLSA 4KAKA 1RX1A 4NX6A 4XT6A 2B3ZA 4TU5X 2ANQA 4QLFA 3LG4A 2HM9A 3F0BX 1RH3A 1M78A 3QLSA 3QLRA 3DL6A 1RE7A 3ZPCA 4KY4A 1IA4A 1DR7A 2OBCA 3UM5A 3ZPGA 3FQFA 1CD2A 3CD2A 1S3WA 3DFRA 1SEJA 3SA2A 3KY8A 3QYLA 5HT4A 2G6VA 2CD2A 3SA1A 4EIGA 2C2TA 3KJSA 4HOGA 1RX8A 3K2HA 4OR7A 4ELBA 3TQBA 1M7AA 3DAUA 5HT5A 4I13A 3K45A 4PSYA 3F91A 4LAHX 3SGYA 3NRRA 4M2XA 4DFRA 2BLCA 3D80A 4H98A 1AO8A 3FYWX 3KGYA 1KMVA 3NZ9X 2HQPA 4KEBA 1BZFA 2ZZAA 1RA2A 4XT4A 5U27A 3DG8A 1RA8A 3UM8A 5ECXA 3CL9A 3F0SX 3NZCX 3NXVA 2GD9A 3SRSX 3CLBA 3FQZA 3QYOA 3E0BA 3F0QX 2L28A 2P4GA 4DPDA 1DISA 3S9UA 3TQ8A 3IROA 2W3BA 4I1NA 4HOFA 4IXGX 3CSEA 4KJKA 4X5FA 1DYHA 4KFJA 4PSSA 1DRFA 3DATA 4KJLA 3TQ9A 4ELFA 3JW5A 3FY9X 1DHIA 2W3MA 3SRUX 1DRAA 3JW3A 2XW7A 1JOMA 1KMSA 2W9TA 3HBBA 4QHVA 4H95A 1DG8A 4P3RA 1QZFA 3QG2A 3N0HA 1DR1A 1E26A 3EEMA 5HPBA 2W3VA 5E8QA 3QGTA 1LY4A 2DRCA 5JG0X 3SRWX 4P3QA 4X5GA 3FQOA 3NZBX 3EX8A
chains in the Genus database with same CATH topology
4KY8A 3FQ0A 3FRAX 3RO9A 3TQAA 1HFPA 3NXTA 4H96A 3FL8A 4KBNA 4EIZA 2BLBA 4QLEA 1CZ3A 3F0UX 3NZDA 4KLXA 1DF7A 1J3JA 5HVEA 4XT7A 5HQZA 4EILA 5HVBA 3DRCA 2DHFA 4FGHA 1RX6A 3FREX 4ELHA 1JOLA 3NTZA 1TDRA 3I8AX 4HA9A 3TD8A 3IA4A 3S3VA 5HSRA 2W3WA 1HFQA 3UM6A 4RGCA 2C2SA 3EELA 3IA5A 3JSUA 3QLWA 3NXOA 1HFRA 1S3VA 1DHJA 1RX3A 1BOZA 3Q1HA 5DFRA 5HSUA 2OIPA 5EAJA 4QI9A 2BLAA 4PTJA 4QLGA 1YHOA 2BL9A 4KL9A 3GI2A 3QLZA 2W9SA 1RC4A 1J3KA 3FRBX 4X5HA 2H2QA 5HQYA 3QFXA 3JVXA 4P68A 1PD8A 5JA3A 3S7AA 3IRMA 4XT5A 2CIGA 3SRRX 4XECX 3NU0A 2KGKA 3NZ6X 2D5NA 1RX2A 3RG9A 3GHCA 3F0XX 3OAFA 4Q67A 1IA3A 1DRBA 3NXYA 5U26A 4XT8A 3NXXA 1RG7A 1RX7A 3DL5A 1DRHA 2HXVA 3GHWA 3F8YA 4KYAA 1DG7A 4ELGA 4M7UA 1J3IA 1U70A 4DDRA 3SAIA 1PDBA 3KFYA 2INQA 4OSGA 3FYVX 1IA2A 1RB3A 1S3UA 3FRFX 3JWFA 4X5IA 3HJ3A 4Q0DA 4X5JA 4G8ZX 3GHVA 1RF7A 4PSTA 1AI9A 3M08A 3SQYX 3D84X 1LY3A 1RA1A 3NZAX 2FZJA 4FGGA 1RA3A 1DR5A 4M6JA 4PTHA 1LUDA 3EIGA 2D0KA 4QJZD 3QL0A 4GH8A 1RD7A 3FRDX 4H97A 5CC9A 2JYBA 2AZNA 3FQVA 4FHBA 5HF2X 2LF1A 3ROAA 4PDJA 4HA7A 3QLXA 5CCCA 4XE6X 1S3YA 2W9HA 1ZDRA 4HOEA 5HI6A 5FDAA 4KD7A 3F0VX 1DHFA 2ANOA 4NX7A 3EEJA 1MVTA 1OHJA 5DXVA 4LAGX 4ELEA 1D1GA 4Q0EA 1RB2A 4ECKA 3DGAA 1RX5A 3QL3A 1RX9A 1DIUA 4LAEX 4EJ1A 3SRQX 4DPHA 3L3RA 3NXRA 1JUVA 3SH2A 1U71A 3KJRA 1DLRA 3IX9A 4XRBA 1OHKA 3F8ZA 7DFRA 2FZIA 1DR4A 3JWKA 4KM0A 1DYRA 4G3MA 4M7VA 4KM2A 2O7PA 3INVA 1DR3A 3IRNA 4KNEA 1RX4A 4KJJA 2FZHA 1U72A 3JTWA 4DP3A 1DG5A 3EEKA 1VJ3A 4LEKX 5HUIA 3FL9A 1IA1A 2ITHA 3SR5X 8DFRA 1DREA 3OCHA 3JWCA 5HF0X 2W9GA 1MVSA 5ECCA 2W3AA 3GYFA 3FQCA 1M79A 4QJCA 1PD9A 3FS6A 3FY8X 4M6LA 3M09A 1AOEA 1DAJA 6DFRA 1DDSA 1DYJA 1KLKA 3R33A 3K74A 3QLYA 1VDRA 4P66A 1RA9A 4IXED 4M6KA 3VCOA 3K47A 1DDRA 4CD2A 3JWMA 3I3RA 4Q6AA 4IXFX 4G95A 2QK8A 1DR2A 1DYIA 1DR6A 1DLSA 4KAKA 1RX1A 4NX6A 4XT6A 2B3ZA 4TU5X 2ANQA 4QLFA 3LG4A 2HM9A 3F0BX 1RH3A 1M78A 3QLSA 3QLRA 3DL6A 1RE7A 3ZPCA 4KY4A 1IA4A 1DR7A 2OBCA 3UM5A 3ZPGA 3FQFA 1CD2A 3CD2A 1S3WA 3DFRA 1SEJA 3SA2A 3KY8A 3QYLA 5HT4A 2G6VA 2CD2A 3SA1A 4EIGA 2C2TA 3KJSA 4HOGA 1RX8A 3K2HA 4OR7A 4ELBA 3TQBA 1M7AA 3DAUA 5HT5A 4I13A 3K45A 4PSYA 3F91A 4LAHX 3SGYA 3NRRA 4M2XA 4DFRA 2BLCA 3D80A 4H98A 1AO8A 3FYWX 3KGYA 1KMVA 3NZ9X 2HQPA 4KEBA 1BZFA 2ZZAA 1RA2A 4XT4A 5U27A 3DG8A 1RA8A 3UM8A 5ECXA 3CL9A 3F0SX 3NZCX 3NXVA 2GD9A 3SRSX 3CLBA 3FQZA 3QYOA 3E0BA 3F0QX 2L28A 2P4GA 4DPDA 1DISA 3S9UA 3TQ8A 3IROA 2W3BA 4I1NA 4HOFA 4IXGX 3CSEA 4KJKA 4X5FA 1DYHA 4KFJA 4PSSA 1DRFA 3DATA 4KJLA 3TQ9A 4ELFA 3JW5A 3FY9X 1DHIA 2W3MA 3SRUX 1DRAA 3JW3A 2XW7A 1JOMA 1KMSA 2W9TA 3HBBA 4QHVA 4H95A 1DG8A 4P3RA 1QZFA 3QG2A 3N0HA 1DR1A 1E26A 3EEMA 5HPBA 2W3VA 5E8QA 3QGTA 1LY4A 2DRCA 5JG0X 3SRWX 4P3QA 4X5GA 3FQOA 3NZBX 3EX8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KY8 A;  3FQ0 A;  3FRA X;  3RO9 A;  3TQA A;  1HFP A;  3NXT A;  4H96 A;  3FL8 A;  4KBN A;  4EIZ A;  2BLB A;  4QLE A;  1CZ3 A;  3F0U X;  3NZD A;  4KLX A;  1DF7 A;  1J3J A;  5HVE A;  4XT7 A;  5HQZ A;  4EIL A;  5HVB A;  3DRC A;  2DHF A;  4FGH A;  1RX6 A;  3FRE X;  4ELH A;  1JOL A;  3NTZ A;  1TDR A;  3I8A X;  4HA9 A;  3TD8 A;  3IA4 A;  3S3V A;  5HSR A;  2W3W A;  1HFQ A;  3UM6 A;  4RGC A;  2C2S A;  3EEL A;  3IA5 A;  3JSU A;  3QLW A;  3NXO A;  1HFR A;  1S3V A;  1DHJ A;  1RX3 A;  1BOZ A;  3Q1H A;  5DFR A;  5HSU A;  2OIP A;  5EAJ A;  4QI9 A;  2BLA A;  4PTJ A;  4QLG A;  1YHO A;  2BL9 A;  4KL9 A;  3GI2 A;  3QLZ A;  2W9S A;  1RC4 A;  1J3K A;  3FRB X;  4X5H A;  2H2Q A;  5HQY A;  3QFX A;  3JVX A;  4P68 A;  1PD8 A;  5JA3 A;  3S7A A;  3IRM A;  4XT5 A;  2CIG A;  3SRR X;  4XEC X;  3NU0 A;  2KGK A;  3NZ6 X;  2D5N A;  1RX2 A;  3RG9 A;  3GHC A;  3F0X X;  3OAF A;  4Q67 A;  1IA3 A;  1DRB A;  3NXY A;  5U26 A;  4XT8 A;  3NXX A;  1RG7 A;  1RX7 A;  3DL5 A;  1DRH A;  2HXV A;  3GHW A;  3F8Y A;  4KYA A;  1DG7 A;  4ELG A;  4M7U A;  1J3I A;  1U70 A;  4DDR A;  3SAI A;  1PDB A;  3KFY A;  2INQ A;  4OSG A;  3FYV X;  1IA2 A;  1RB3 A;  1S3U A;  3FRF X;  3JWF A;  4X5I A;  3HJ3 A;  4Q0D A;  4X5J A;  4G8Z X;  3GHV A;  1RF7 A;  4PST A;  1AI9 A;  3M08 A;  3SQY X;  3D84 X;  1LY3 A;  1RA1 A;  3NZA X;  2FZJ A;  4FGG A;  1RA3 A;  1DR5 A;  4M6J A;  4PTH A;  1LUD A;  3EIG A;  2D0K A;  4QJZ D;  3QL0 A;  4GH8 A;  1RD7 A;  3FRD X;  4H97 A;  5CC9 A;  2JYB A;  2AZN A;  3FQV A;  4FHB A;  5HF2 X;  2LF1 A;  3ROA A;  4PDJ A;  4HA7 A;  3QLX A;  5CCC A;  4XE6 X;  1S3Y A;  2W9H A;  1ZDR A;  4HOE A;  5HI6 A;  5FDA A;  4KD7 A;  3F0V X;  1DHF A;  2ANO A;  4NX7 A;  3EEJ A;  1MVT A;  1OHJ A;  5DXV A;  4LAG X;  4ELE A;  1D1G A;  4Q0E A;  1RB2 A;  4ECK A;  3DGA A;  1RX5 A;  3QL3 A;  1RX9 A;  1DIU A;  4LAE X;  4EJ1 A;  3SRQ X;  4DPH A;  3L3R A;  3NXR A;  1JUV A;  3SH2 A;  1U71 A;  3KJR A;  1DLR A;  3IX9 A;  4XRB A;  1OHK A;  3F8Z A;  7DFR A;  2FZI A;  1DR4 A;  3JWK A;  4KM0 A;  1DYR A;  4G3M A;  4M7V A;  4KM2 A;  2O7P A;  3INV A;  1DR3 A;  3IRN A;  4KNE A;  1RX4 A;  4KJJ A;  2FZH A;  1U72 A;  3JTW A;  4DP3 A;  1DG5 A;  3EEK A;  1VJ3 A;  4LEK X;  5HUI A;  3FL9 A;  1IA1 A;  2ITH A;  3SR5 X;  8DFR A;  1DRE A;  3OCH A;  3JWC A;  5HF0 X;  2W9G A;  1MVS A;  5ECC A;  2W3A A;  3GYF A;  3FQC A;  1M79 A;  4QJC A;  1PD9 A;  3FS6 A;  3FY8 X;  4M6L A;  3M09 A;  1AOE A;  1DAJ A;  6DFR A;  1DDS A;  1DYJ A;  1KLK A;  3R33 A;  3K74 A;  3QLY A;  1VDR A;  4P66 A;  1RA9 A;  4IXE D;  4M6K A;  3VCO A;  3K47 A;  1DDR A;  4CD2 A;  3JWM A;  3I3R A;  4Q6A A;  4IXF X;  4G95 A;  2QK8 A;  1DR2 A;  1DYI A;  1DR6 A;  1DLS A;  4KAK A;  1RX1 A;  4NX6 A;  4XT6 A;  2B3Z A;  4TU5 X;  2ANQ A;  4QLF A;  3LG4 A;  2HM9 A;  3F0B X;  1RH3 A;  1M78 A;  3QLS A;  3QLR A;  3DL6 A;  1RE7 A;  3ZPC A;  4KY4 A;  1IA4 A;  1DR7 A;  2OBC A;  3UM5 A;  3ZPG A;  3FQF A;  1CD2 A;  3CD2 A;  1S3W A;  3DFR A;  1SEJ A;  3SA2 A;  3KY8 A;  3QYL A;  5HT4 A;  2G6V A;  2CD2 A;  3SA1 A;  4EIG A;  2C2T A;  3KJS A;  4HOG A;  1RX8 A;  3K2H A;  4OR7 A;  4ELB A;  3TQB A;  1M7A A;  3DAU A;  5HT5 A;  4I13 A;  3K45 A;  4PSY A;  3F91 A;  4LAH X;  3SGY A;  3NRR A;  4M2X A;  4DFR A;  2BLC A;  3D80 A;  4H98 A;  1AO8 A;  3FYW X;  3KGY A;  1KMV A;  3NZ9 X;  2HQP A;  4KEB A;  1BZF A;  2ZZA A;  1RA2 A;  4XT4 A;  5U27 A;  3DG8 A;  1RA8 A;  3UM8 A;  5ECX A;  3CL9 A;  3F0S X;  3NZC X;  3NXV A;  2GD9 A;  3SRS X;  3CLB A;  3FQZ A;  3QYO A;  3E0B A;  3F0Q X;  2L28 A;  2P4G A;  4DPD A;  1DIS A;  3S9U A;  3TQ8 A;  3IRO A;  2W3B A;  4I1N A;  4HOF A;  4IXG X;  3CSE A;  4KJK A;  4X5F A;  1DYH A;  4KFJ A;  4PSS A;  1DRF A;  3DAT A;  4KJL A;  3TQ9 A;  4ELF A;  3JW5 A;  3FY9 X;  1DHI A;  2W3M A;  3SRU X;  1DRA A;  3JW3 A;  2XW7 A;  1JOM A;  1KMS A;  2W9T A;  3HBB A;  4QHV A;  4H95 A;  1DG8 A;  4P3R A;  1QZF A;  3QG2 A;  3N0H A;  1DR1 A;  1E26 A;  3EEM A;  5HPB A;  2W3V A;  5E8Q A;  3QGT A;  1LY4 A;  2DRC A;  5JG0 X;  3SRW X;  4P3Q A;  4X5G A;  3FQO A;  3NZB X;  3EX8 A; 
#chains in the Genus database with same CATH topology
 4KY8 A;  3FQ0 A;  3FRA X;  3RO9 A;  3TQA A;  1HFP A;  3NXT A;  4H96 A;  3FL8 A;  4KBN A;  4EIZ A;  2BLB A;  4QLE A;  1CZ3 A;  3F0U X;  3NZD A;  4KLX A;  1DF7 A;  1J3J A;  5HVE A;  4XT7 A;  5HQZ A;  4EIL A;  5HVB A;  3DRC A;  2DHF A;  4FGH A;  1RX6 A;  3FRE X;  4ELH A;  1JOL A;  3NTZ A;  1TDR A;  3I8A X;  4HA9 A;  3TD8 A;  3IA4 A;  3S3V A;  5HSR A;  2W3W A;  1HFQ A;  3UM6 A;  4RGC A;  2C2S A;  3EEL A;  3IA5 A;  3JSU A;  3QLW A;  3NXO A;  1HFR A;  1S3V A;  1DHJ A;  1RX3 A;  1BOZ A;  3Q1H A;  5DFR A;  5HSU A;  2OIP A;  5EAJ A;  4QI9 A;  2BLA A;  4PTJ A;  4QLG A;  1YHO A;  2BL9 A;  4KL9 A;  3GI2 A;  3QLZ A;  2W9S A;  1RC4 A;  1J3K A;  3FRB X;  4X5H A;  2H2Q A;  5HQY A;  3QFX A;  3JVX A;  4P68 A;  1PD8 A;  5JA3 A;  3S7A A;  3IRM A;  4XT5 A;  2CIG A;  3SRR X;  4XEC X;  3NU0 A;  2KGK A;  3NZ6 X;  2D5N A;  1RX2 A;  3RG9 A;  3GHC A;  3F0X X;  3OAF A;  4Q67 A;  1IA3 A;  1DRB A;  3NXY A;  5U26 A;  4XT8 A;  3NXX A;  1RG7 A;  1RX7 A;  3DL5 A;  1DRH A;  2HXV A;  3GHW A;  3F8Y A;  4KYA A;  1DG7 A;  4ELG A;  4M7U A;  1J3I A;  1U70 A;  4DDR A;  3SAI A;  1PDB A;  3KFY A;  2INQ A;  4OSG A;  3FYV X;  1IA2 A;  1RB3 A;  1S3U A;  3FRF X;  3JWF A;  4X5I A;  3HJ3 A;  4Q0D A;  4X5J A;  4G8Z X;  3GHV A;  1RF7 A;  4PST A;  1AI9 A;  3M08 A;  3SQY X;  3D84 X;  1LY3 A;  1RA1 A;  3NZA X;  2FZJ A;  4FGG A;  1RA3 A;  1DR5 A;  4M6J A;  4PTH A;  1LUD A;  3EIG A;  2D0K A;  4QJZ D;  3QL0 A;  4GH8 A;  1RD7 A;  3FRD X;  4H97 A;  5CC9 A;  2JYB A;  2AZN A;  3FQV A;  4FHB A;  5HF2 X;  2LF1 A;  3ROA A;  4PDJ A;  4HA7 A;  3QLX A;  5CCC A;  4XE6 X;  1S3Y A;  2W9H A;  1ZDR A;  4HOE A;  5HI6 A;  5FDA A;  4KD7 A;  3F0V X;  1DHF A;  2ANO A;  4NX7 A;  3EEJ A;  1MVT A;  1OHJ A;  5DXV A;  4LAG X;  4ELE A;  1D1G A;  4Q0E A;  1RB2 A;  4ECK A;  3DGA A;  1RX5 A;  3QL3 A;  1RX9 A;  1DIU A;  4LAE X;  4EJ1 A;  3SRQ X;  4DPH A;  3L3R A;  3NXR A;  1JUV A;  3SH2 A;  1U71 A;  3KJR A;  1DLR A;  3IX9 A;  4XRB A;  1OHK A;  3F8Z A;  7DFR A;  2FZI A;  1DR4 A;  3JWK A;  4KM0 A;  1DYR A;  4G3M A;  4M7V A;  4KM2 A;  2O7P A;  3INV A;  1DR3 A;  3IRN A;  4KNE A;  1RX4 A;  4KJJ A;  2FZH A;  1U72 A;  3JTW A;  4DP3 A;  1DG5 A;  3EEK A;  1VJ3 A;  4LEK X;  5HUI A;  3FL9 A;  1IA1 A;  2ITH A;  3SR5 X;  8DFR A;  1DRE A;  3OCH A;  3JWC A;  5HF0 X;  2W9G A;  1MVS A;  5ECC A;  2W3A A;  3GYF A;  3FQC A;  1M79 A;  4QJC A;  1PD9 A;  3FS6 A;  3FY8 X;  4M6L A;  3M09 A;  1AOE A;  1DAJ A;  6DFR A;  1DDS A;  1DYJ A;  1KLK A;  3R33 A;  3K74 A;  3QLY A;  1VDR A;  4P66 A;  1RA9 A;  4IXE D;  4M6K A;  3VCO A;  3K47 A;  1DDR A;  4CD2 A;  3JWM A;  3I3R A;  4Q6A A;  4IXF X;  4G95 A;  2QK8 A;  1DR2 A;  1DYI A;  1DR6 A;  1DLS A;  4KAK A;  1RX1 A;  4NX6 A;  4XT6 A;  2B3Z A;  4TU5 X;  2ANQ A;  4QLF A;  3LG4 A;  2HM9 A;  3F0B X;  1RH3 A;  1M78 A;  3QLS A;  3QLR A;  3DL6 A;  1RE7 A;  3ZPC A;  4KY4 A;  1IA4 A;  1DR7 A;  2OBC A;  3UM5 A;  3ZPG A;  3FQF A;  1CD2 A;  3CD2 A;  1S3W A;  3DFR A;  1SEJ A;  3SA2 A;  3KY8 A;  3QYL A;  5HT4 A;  2G6V A;  2CD2 A;  3SA1 A;  4EIG A;  2C2T A;  3KJS A;  4HOG A;  1RX8 A;  3K2H A;  4OR7 A;  4ELB A;  3TQB A;  1M7A A;  3DAU A;  5HT5 A;  4I13 A;  3K45 A;  4PSY A;  3F91 A;  4LAH X;  3SGY A;  3NRR A;  4M2X A;  4DFR A;  2BLC A;  3D80 A;  4H98 A;  1AO8 A;  3FYW X;  3KGY A;  1KMV A;  3NZ9 X;  2HQP A;  4KEB A;  1BZF A;  2ZZA A;  1RA2 A;  4XT4 A;  5U27 A;  3DG8 A;  1RA8 A;  3UM8 A;  5ECX A;  3CL9 A;  3F0S X;  3NZC X;  3NXV A;  2GD9 A;  3SRS X;  3CLB A;  3FQZ A;  3QYO A;  3E0B A;  3F0Q X;  2L28 A;  2P4G A;  4DPD A;  1DIS A;  3S9U A;  3TQ8 A;  3IRO A;  2W3B A;  4I1N A;  4HOF A;  4IXG X;  3CSE A;  4KJK A;  4X5F A;  1DYH A;  4KFJ A;  4PSS A;  1DRF A;  3DAT A;  4KJL A;  3TQ9 A;  4ELF A;  3JW5 A;  3FY9 X;  1DHI A;  2W3M A;  3SRU X;  1DRA A;  3JW3 A;  2XW7 A;  1JOM A;  1KMS A;  2W9T A;  3HBB A;  4QHV A;  4H95 A;  1DG8 A;  4P3R A;  1QZF A;  3QG2 A;  3N0H A;  1DR1 A;  1E26 A;  3EEM A;  5HPB A;  2W3V A;  5E8Q A;  3QGT A;  1LY4 A;  2DRC A;  5JG0 X;  3SRW X;  4P3Q A;  4X5G A;  3FQO A;  3NZB X;  3EX8 A; 
#chains in the Genus database with same CATH homology
 4KY8 A;  3FQ0 A;  3FRA X;  3RO9 A;  3TQA A;  1HFP A;  3NXT A;  4H96 A;  3FL8 A;  4KBN A;  4EIZ A;  2BLB A;  4QLE A;  1CZ3 A;  3F0U X;  3NZD A;  4KLX A;  1DF7 A;  1J3J A;  5HVE A;  4XT7 A;  5HQZ A;  4EIL A;  5HVB A;  3DRC A;  2DHF A;  4FGH A;  1RX6 A;  3FRE X;  4ELH A;  1JOL A;  3NTZ A;  1TDR A;  3I8A X;  4HA9 A;  3TD8 A;  3IA4 A;  3S3V A;  5HSR A;  2W3W A;  1HFQ A;  3UM6 A;  4RGC A;  2C2S A;  3EEL A;  3IA5 A;  3JSU A;  3QLW A;  3NXO A;  1HFR A;  1S3V A;  1DHJ A;  1RX3 A;  1BOZ A;  3Q1H A;  5DFR A;  5HSU A;  2OIP A;  5EAJ A;  4QI9 A;  2BLA A;  4PTJ A;  4QLG A;  1YHO A;  2BL9 A;  4KL9 A;  3GI2 A;  3QLZ A;  2W9S A;  1RC4 A;  1J3K A;  3FRB X;  4X5H A;  2H2Q A;  5HQY A;  3QFX A;  3JVX A;  4P68 A;  1PD8 A;  5JA3 A;  3S7A A;  3IRM A;  4XT5 A;  2CIG A;  3SRR X;  4XEC X;  3NU0 A;  2KGK A;  3NZ6 X;  2D5N A;  1RX2 A;  3RG9 A;  3GHC A;  3F0X X;  3OAF A;  4Q67 A;  1IA3 A;  1DRB A;  3NXY A;  5U26 A;  4XT8 A;  3NXX A;  1RG7 A;  1RX7 A;  3DL5 A;  1DRH A;  2HXV A;  3GHW A;  3F8Y A;  4KYA A;  1DG7 A;  4ELG A;  4M7U A;  1J3I A;  1U70 A;  4DDR A;  3SAI A;  1PDB A;  3KFY A;  2INQ A;  4OSG A;  3FYV X;  1IA2 A;  1RB3 A;  1S3U A;  3FRF X;  3JWF A;  4X5I A;  3HJ3 A;  4Q0D A;  4X5J A;  4G8Z X;  3GHV A;  1RF7 A;  4PST A;  1AI9 A;  3M08 A;  3SQY X;  3D84 X;  1LY3 A;  1RA1 A;  3NZA X;  2FZJ A;  4FGG A;  1RA3 A;  1DR5 A;  4M6J A;  4PTH A;  1LUD A;  3EIG A;  2D0K A;  4QJZ D;  3QL0 A;  4GH8 A;  1RD7 A;  3FRD X;  4H97 A;  5CC9 A;  2JYB A;  2AZN A;  3FQV A;  4FHB A;  5HF2 X;  2LF1 A;  3ROA A;  4PDJ A;  4HA7 A;  3QLX A;  5CCC A;  4XE6 X;  1S3Y A;  2W9H A;  1ZDR A;  4HOE A;  5HI6 A;  5FDA A;  4KD7 A;  3F0V X;  1DHF A;  2ANO A;  4NX7 A;  3EEJ A;  1MVT A;  1OHJ A;  5DXV A;  4LAG X;  4ELE A;  1D1G A;  4Q0E A;  1RB2 A;  4ECK A;  3DGA A;  1RX5 A;  3QL3 A;  1RX9 A;  1DIU A;  4LAE X;  4EJ1 A;  3SRQ X;  4DPH A;  3L3R A;  3NXR A;  1JUV A;  3SH2 A;  1U71 A;  3KJR A;  1DLR A;  3IX9 A;  4XRB A;  1OHK A;  3F8Z A;  7DFR A;  2FZI A;  1DR4 A;  3JWK A;  4KM0 A;  1DYR A;  4G3M A;  4M7V A;  4KM2 A;  2O7P A;  3INV A;  1DR3 A;  3IRN A;  4KNE A;  1RX4 A;  4KJJ A;  2FZH A;  1U72 A;  3JTW A;  4DP3 A;  1DG5 A;  3EEK A;  1VJ3 A;  4LEK X;  5HUI A;  3FL9 A;  1IA1 A;  2ITH A;  3SR5 X;  8DFR A;  1DRE A;  3OCH A;  3JWC A;  5HF0 X;  2W9G A;  1MVS A;  5ECC A;  2W3A A;  3GYF A;  3FQC A;  1M79 A;  4QJC A;  1PD9 A;  3FS6 A;  3FY8 X;  4M6L A;  3M09 A;  1AOE A;  1DAJ A;  6DFR A;  1DDS A;  1DYJ A;  1KLK A;  3R33 A;  3K74 A;  3QLY A;  1VDR A;  4P66 A;  1RA9 A;  4IXE D;  4M6K A;  3VCO A;  3K47 A;  1DDR A;  4CD2 A;  3JWM A;  3I3R A;  4Q6A A;  4IXF X;  4G95 A;  2QK8 A;  1DR2 A;  1DYI A;  1DR6 A;  1DLS A;  4KAK A;  1RX1 A;  4NX6 A;  4XT6 A;  2B3Z A;  4TU5 X;  2ANQ A;  4QLF A;  3LG4 A;  2HM9 A;  3F0B X;  1RH3 A;  1M78 A;  3QLS A;  3QLR A;  3DL6 A;  1RE7 A;  3ZPC A;  4KY4 A;  1IA4 A;  1DR7 A;  2OBC A;  3UM5 A;  3ZPG A;  3FQF A;  1CD2 A;  3CD2 A;  1S3W A;  3DFR A;  1SEJ A;  3SA2 A;  3KY8 A;  3QYL A;  5HT4 A;  2G6V A;  2CD2 A;  3SA1 A;  4EIG A;  2C2T A;  3KJS A;  4HOG A;  1RX8 A;  3K2H A;  4OR7 A;  4ELB A;  3TQB A;  1M7A A;  3DAU A;  5HT5 A;  4I13 A;  3K45 A;  4PSY A;  3F91 A;  4LAH X;  3SGY A;  3NRR A;  4M2X A;  4DFR A;  2BLC A;  3D80 A;  4H98 A;  1AO8 A;  3FYW X;  3KGY A;  1KMV A;  3NZ9 X;  2HQP A;  4KEB A;  1BZF A;  2ZZA A;  1RA2 A;  4XT4 A;  5U27 A;  3DG8 A;  1RA8 A;  3UM8 A;  5ECX A;  3CL9 A;  3F0S X;  3NZC X;  3NXV A;  2GD9 A;  3SRS X;  3CLB A;  3FQZ A;  3QYO A;  3E0B A;  3F0Q X;  2L28 A;  2P4G A;  4DPD A;  1DIS A;  3S9U A;  3TQ8 A;  3IRO A;  2W3B A;  4I1N A;  4HOF A;  4IXG X;  3CSE A;  4KJK A;  4X5F A;  1DYH A;  4KFJ A;  4PSS A;  1DRF A;  3DAT A;  4KJL A;  3TQ9 A;  4ELF A;  3JW5 A;  3FY9 X;  1DHI A;  2W3M A;  3SRU X;  1DRA A;  3JW3 A;  2XW7 A;  1JOM A;  1KMS A;  2W9T A;  3HBB A;  4QHV A;  4H95 A;  1DG8 A;  4P3R A;  1QZF A;  3QG2 A;  3N0H A;  1DR1 A;  1E26 A;  3EEM A;  5HPB A;  2W3V A;  5E8Q A;  3QGT A;  1LY4 A;  2DRC A;  5JG0 X;  3SRW X;  4P3Q A;  4X5G A;  3FQO A;  3NZB X;  3EX8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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