6DFRA

Crystal structures of escherichia coli dihydrofolate reductase. the nadp+ holoenzyme and the folate(dot)nadp+ ternary complex. substrate binding and a model for the transition state
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
159
structure length
154
Chain Sequence
MISLIAALAVDRVIGPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 40
structure length 154
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1988-10-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 6dfrA00
1DISA 3OAFA 3NZ6X 2HQPA 1DREA 1DRHA 1E26A 3IA4A 3I3RA 2W3BA 4KNEA 4TU5X 4NX7A 2P4GA 2LF1A 4LAHX 1KMSA 4KY4A 5HSUA 4M6KA 1S3WA 2OIPA 3GHWA 4G8ZX 3DG8A 1M7AA 1RB3A 3F0VX 4P68A 4P3RA 3QG2A 3HBBA 4QJZD 2KGKA 4QLFA 4X5FA 1RH3A 1RX3A 3K47A 2D5NA 3KFYA 1RE7A 1DR2A 3EEJA 4I1NA 3NZBX 3EIGA 7DFRA 5EAJA 1DR5A 3UM5A 5CC9A 3DL6A 5DXVA 5DFRA 4PSYA 3QLWA 4KD7A 1RG7A 2W9GA 3SRSX 3F0XX 3NTZA 3I8AX 4KYAA 5HQYA 3UM8A 1CD2A 4G95A 3NZ9X 4XT6A 1DLSA 4DPDA 1DHJA 3Q1HA 1DF7A 1DIUA 3FYVX 4DPHA 2L28A 3FY9X 4PTJA 1DR4A 3GYFA 3QLYA 2BLAA 1RX1A 2QK8A 4KJLA 4KFJA 4EILA 1RX8A 4XRBA 2INQA 3K45A 3D80A 1HFRA 4KLXA 4ECKA 1DRFA 2ITHA 2ZZAA 3DGAA 3FS6A 3DAUA 3ZPCA 3SA1A 4XT7A 3IRMA 1OHJA 4X5JA 2XW7A 5HI6A 4FGHA 2ANQA 3TD8A 2BLCA 3NZDA 3KY8A 3TQBA 1DG7A 3S9UA 1PD8A 1PD9A 5U27A 1AI9A 3TQ8A 3FQCA 4GH8A 4IXFX 1LUDA 1RX6A 2HM9A 3RO9A 3M08A 3JW3A 4PSSA 1RA1A 1RB2A 2W9HA 2DRCA 4PDJA 3OCHA 1IA1A 1DAJA 4EJ1A 3SRUX 2W3AA 3DL5A 4XT4A 3F0UX 3VCOA 2CD2A 3JVXA 3FQVA 4QHVA 1DR3A 4HA9A 4X5GA 2C2TA 3JWKA 3INVA 4H98A 8DFRA 4QLGA 2DHFA 4KBNA 1MVTA 4M6LA 3QFXA 1CZ3A 5ECXA 4P3QA 4X5IA 3SH2A 2C2SA 3FRAX 5JA3A 1JUVA 1S3UA 3E0BA 3KJSA 4KM2A 4QJCA 1RX5A 4QLEA 1DDRA 3EX8A 3JTWA 3CSEA 3SRWX 2W3WA 1J3IA 5HUIA 4Q67A 3IROA 1RA3A 3FREX 3QL0A 5U26A 1RX9A 3JSUA 1DG5A 1DYHA 3NXVA 4KM0A 3FQZA 4M7VA 3JWMA 4EIZA 6DFRA 4KL9A 2FZIA 1RX7A 3S7AA 4ELEA 1S3YA 5HVBA 3NRRA 3F0BX 3DATA 3ZPGA 3SRRX 1QZFA 1KMVA 3SAIA 5HPBA 3F8ZA 3QLRA 3NU0A 5HQZA 1M78A 1BOZA 3NXRA 4NX6A 4XT5A 3FY8X 2FZJA 3FRFX 3JW5A 4P66A 3SGYA 1DDSA 2ANOA 3JWFA 1DRAA 3L3RA 3QYLA 1JOLA 2B3ZA 4DP3A 1VJ3A 1DR7A 4Q0EA 4EIGA 1AOEA 4FGGA 3TQAA 3SQYX 3QLXA 3KGYA 1MVSA 4XECX 4HA7A 1TDRA 2W3VA 2H2QA 4KEBA 2BL9A 4KJKA 1U71A 3FRBX 4Q0DA 3IA5A 4IXGX 1BZFA 2HXVA 3K74A 1DYIA 3IRNA 4I13A 2GD9A 5HF2X 1KLKA 4KY8A 3CLBA 3F91A 3DRCA 3TQ9A 1D1GA 1U70A 1RD7A 4ELFA 4XT8A 4IXED 1YHOA 4OSGA 4RGCA 2W9TA 1DHIA 3FL9A 1RF7A 5FDAA 1PDBA 4X5HA 2AZNA 3CD2A 3CL9A 3GHCA 3SR5X 4CD2A 3S3VA 4LEKX 3M09A 4XE6X 1AO8A 3RG9A 4LAGX 4M7UA 5HT4A 1LY3A 1DRBA 3DFRA 1HFQA 4KJJA 2G6VA 1VDRA 3NXXA 4HOGA 3NZCX 3FRDX 3QGTA 3FL8A 3FQFA 1U72A 3SRQX 3UM6A 4ELHA 1OHKA 3NXTA 3HJ3A 3JWCA 3FQOA 4H97A 4KAKA 3F0SX 3F8YA 2D0KA 5ECCA 5HVEA 3QYOA 1DR1A 4PTHA 1JOMA 2O7PA 5HT5A 3R33A 4DDRA 4M6JA 4DFRA 3N0HA 2OBCA 1RA8A 2BLBA 1ZDRA 1DYRA 4Q6AA 4ELGA 3QLZA 1J3JA 2FZHA 1S3VA 4FHBA 1IA2A 4ELBA 4H95A 4QI9A 1RC4A 5JG0X 3FYWX 3F0QX 1DG8A 3ROAA 3EEMA 3IX9A 3EEKA 3EELA 3SA2A 1LY4A 1SEJA 1RA2A 4G3MA 1DR6A 1RX2A 1RA9A 2W3MA 4HOFA 3GHVA 3NZAX 1DYJA 3QLSA 1DLRA 1J3KA 3GI2A 4LAEX 4M2XA 1RX4A 1HFPA 3K2HA 1IA4A 5CCCA 1DHFA 2W9SA 4OR7A 5E8QA 3D84X 2CIGA 4HOEA 3NXYA 1M79A 5HF0X 3FQ0A 3QL3A 4H96A 2JYBA 3KJRA 3LG4A 1IA3A 3NXOA 4PSTA 5HSRA
chains in the Genus database with same CATH superfamily
1DISA 3OAFA 3NZ6X 2HQPA 1DREA 1DRHA 1E26A 3IA4A 3I3RA 2W3BA 4KNEA 4TU5X 4NX7A 2P4GA 2LF1A 4LAHX 1KMSA 4KY4A 5HSUA 4M6KA 1S3WA 2OIPA 3GHWA 4G8ZX 3DG8A 1M7AA 1RB3A 3F0VX 4P68A 4P3RA 3QG2A 3HBBA 4QJZD 2KGKA 4QLFA 4X5FA 1RH3A 1RX3A 3K47A 2D5NA 3KFYA 1RE7A 1DR2A 3EEJA 4I1NA 3NZBX 3EIGA 7DFRA 5EAJA 1DR5A 3UM5A 5CC9A 3DL6A 5DXVA 5DFRA 4PSYA 3QLWA 4KD7A 1RG7A 2W9GA 3SRSX 3F0XX 3NTZA 3I8AX 4KYAA 5HQYA 3UM8A 1CD2A 4G95A 3NZ9X 4XT6A 1DLSA 4DPDA 1DHJA 3Q1HA 1DF7A 1DIUA 3FYVX 4DPHA 2L28A 3FY9X 4PTJA 1DR4A 3GYFA 3QLYA 2BLAA 1RX1A 2QK8A 4KJLA 4KFJA 4EILA 1RX8A 4XRBA 2INQA 3K45A 3D80A 1HFRA 4KLXA 4ECKA 1DRFA 2ITHA 2ZZAA 3DGAA 3FS6A 3DAUA 3ZPCA 3SA1A 4XT7A 3IRMA 1OHJA 4X5JA 2XW7A 5HI6A 4FGHA 2ANQA 3TD8A 2BLCA 3NZDA 3KY8A 3TQBA 1DG7A 3S9UA 1PD8A 1PD9A 5U27A 1AI9A 3TQ8A 3FQCA 4GH8A 4IXFX 1LUDA 1RX6A 2HM9A 3RO9A 3M08A 3JW3A 4PSSA 1RA1A 1RB2A 2W9HA 2DRCA 4PDJA 3OCHA 1IA1A 1DAJA 4EJ1A 3SRUX 2W3AA 3DL5A 4XT4A 3F0UX 3VCOA 2CD2A 3JVXA 3FQVA 4QHVA 1DR3A 4HA9A 4X5GA 2C2TA 3JWKA 3INVA 4H98A 8DFRA 4QLGA 2DHFA 4KBNA 1MVTA 4M6LA 3QFXA 1CZ3A 5ECXA 4P3QA 4X5IA 3SH2A 2C2SA 3FRAX 5JA3A 1JUVA 1S3UA 3E0BA 3KJSA 4KM2A 4QJCA 1RX5A 4QLEA 1DDRA 3EX8A 3JTWA 3CSEA 3SRWX 2W3WA 1J3IA 5HUIA 4Q67A 3IROA 1RA3A 3FREX 3QL0A 5U26A 1RX9A 3JSUA 1DG5A 1DYHA 3NXVA 4KM0A 3FQZA 4M7VA 3JWMA 4EIZA 6DFRA 4KL9A 2FZIA 1RX7A 3S7AA 4ELEA 1S3YA 5HVBA 3NRRA 3F0BX 3DATA 3ZPGA 3SRRX 1QZFA 1KMVA 3SAIA 5HPBA 3F8ZA 3QLRA 3NU0A 5HQZA 1M78A 1BOZA 3NXRA 4NX6A 4XT5A 3FY8X 2FZJA 3FRFX 3JW5A 4P66A 3SGYA 1DDSA 2ANOA 3JWFA 1DRAA 3L3RA 3QYLA 1JOLA 2B3ZA 4DP3A 1VJ3A 1DR7A 4Q0EA 4EIGA 1AOEA 4FGGA 3TQAA 3SQYX 3QLXA 3KGYA 1MVSA 4XECX 4HA7A 1TDRA 2W3VA 2H2QA 4KEBA 2BL9A 4KJKA 1U71A 3FRBX 4Q0DA 3IA5A 4IXGX 1BZFA 2HXVA 3K74A 1DYIA 3IRNA 4I13A 2GD9A 5HF2X 1KLKA 4KY8A 3CLBA 3F91A 3DRCA 3TQ9A 1D1GA 1U70A 1RD7A 4ELFA 4XT8A 4IXED 1YHOA 4OSGA 4RGCA 2W9TA 1DHIA 3FL9A 1RF7A 5FDAA 1PDBA 4X5HA 2AZNA 3CD2A 3CL9A 3GHCA 3SR5X 4CD2A 3S3VA 4LEKX 3M09A 4XE6X 1AO8A 3RG9A 4LAGX 4M7UA 5HT4A 1LY3A 1DRBA 3DFRA 1HFQA 4KJJA 2G6VA 1VDRA 3NXXA 4HOGA 3NZCX 3FRDX 3QGTA 3FL8A 3FQFA 1U72A 3SRQX 3UM6A 4ELHA 1OHKA 3NXTA 3HJ3A 3JWCA 3FQOA 4H97A 4KAKA 3F0SX 3F8YA 2D0KA 5ECCA 5HVEA 3QYOA 1DR1A 4PTHA 1JOMA 2O7PA 5HT5A 3R33A 4DDRA 4M6JA 4DFRA 3N0HA 2OBCA 1RA8A 2BLBA 1ZDRA 1DYRA 4Q6AA 4ELGA 3QLZA 1J3JA 2FZHA 1S3VA 4FHBA 1IA2A 4ELBA 4H95A 4QI9A 1RC4A 5JG0X 3FYWX 3F0QX 1DG8A 3ROAA 3EEMA 3IX9A 3EEKA 3EELA 3SA2A 1LY4A 1SEJA 1RA2A 4G3MA 1DR6A 1RX2A 1RA9A 2W3MA 4HOFA 3GHVA 3NZAX 1DYJA 3QLSA 1DLRA 1J3KA 3GI2A 4LAEX 4M2XA 1RX4A 1HFPA 3K2HA 1IA4A 5CCCA 1DHFA 2W9SA 4OR7A 5E8QA 3D84X 2CIGA 4HOEA 3NXYA 1M79A 5HF0X 3FQ0A 3QL3A 4H96A 2JYBA 3KJRA 3LG4A 1IA3A 3NXOA 4PSTA 5HSRA
chains in the Genus database with same CATH topology
1DISA 3OAFA 3NZ6X 2HQPA 1DREA 1DRHA 1E26A 3IA4A 3I3RA 2W3BA 4KNEA 4TU5X 4NX7A 2P4GA 2LF1A 4LAHX 1KMSA 4KY4A 5HSUA 4M6KA 1S3WA 2OIPA 3GHWA 4G8ZX 3DG8A 1M7AA 1RB3A 3F0VX 4P68A 4P3RA 3QG2A 3HBBA 4QJZD 2KGKA 4QLFA 4X5FA 1RH3A 1RX3A 3K47A 2D5NA 3KFYA 1RE7A 1DR2A 3EEJA 4I1NA 3NZBX 3EIGA 7DFRA 5EAJA 1DR5A 3UM5A 5CC9A 3DL6A 5DXVA 5DFRA 4PSYA 3QLWA 4KD7A 1RG7A 2W9GA 3SRSX 3F0XX 3NTZA 3I8AX 4KYAA 5HQYA 3UM8A 1CD2A 4G95A 3NZ9X 4XT6A 1DLSA 4DPDA 1DHJA 3Q1HA 1DF7A 1DIUA 3FYVX 4DPHA 2L28A 3FY9X 4PTJA 1DR4A 3GYFA 3QLYA 2BLAA 1RX1A 2QK8A 4KJLA 4KFJA 4EILA 1RX8A 4XRBA 2INQA 3K45A 3D80A 1HFRA 4KLXA 4ECKA 1DRFA 2ITHA 2ZZAA 3DGAA 3FS6A 3DAUA 3ZPCA 3SA1A 4XT7A 3IRMA 1OHJA 4X5JA 2XW7A 5HI6A 4FGHA 2ANQA 3TD8A 2BLCA 3NZDA 3KY8A 3TQBA 1DG7A 3S9UA 1PD8A 1PD9A 5U27A 1AI9A 3TQ8A 3FQCA 4GH8A 4IXFX 1LUDA 1RX6A 2HM9A 3RO9A 3M08A 3JW3A 4PSSA 1RA1A 1RB2A 2W9HA 2DRCA 4PDJA 3OCHA 1IA1A 1DAJA 4EJ1A 3SRUX 2W3AA 3DL5A 4XT4A 3F0UX 3VCOA 2CD2A 3JVXA 3FQVA 4QHVA 1DR3A 4HA9A 4X5GA 2C2TA 3JWKA 3INVA 4H98A 8DFRA 4QLGA 2DHFA 4KBNA 1MVTA 4M6LA 3QFXA 1CZ3A 5ECXA 4P3QA 4X5IA 3SH2A 2C2SA 3FRAX 5JA3A 1JUVA 1S3UA 3E0BA 3KJSA 4KM2A 4QJCA 1RX5A 4QLEA 1DDRA 3EX8A 3JTWA 3CSEA 3SRWX 2W3WA 1J3IA 5HUIA 4Q67A 3IROA 1RA3A 3FREX 3QL0A 5U26A 1RX9A 3JSUA 1DG5A 1DYHA 3NXVA 4KM0A 3FQZA 4M7VA 3JWMA 4EIZA 6DFRA 4KL9A 2FZIA 1RX7A 3S7AA 4ELEA 1S3YA 5HVBA 3NRRA 3F0BX 3DATA 3ZPGA 3SRRX 1QZFA 1KMVA 3SAIA 5HPBA 3F8ZA 3QLRA 3NU0A 5HQZA 1M78A 1BOZA 3NXRA 4NX6A 4XT5A 3FY8X 2FZJA 3FRFX 3JW5A 4P66A 3SGYA 1DDSA 2ANOA 3JWFA 1DRAA 3L3RA 3QYLA 1JOLA 2B3ZA 4DP3A 1VJ3A 1DR7A 4Q0EA 4EIGA 1AOEA 4FGGA 3TQAA 3SQYX 3QLXA 3KGYA 1MVSA 4XECX 4HA7A 1TDRA 2W3VA 2H2QA 4KEBA 2BL9A 4KJKA 1U71A 3FRBX 4Q0DA 3IA5A 4IXGX 1BZFA 2HXVA 3K74A 1DYIA 3IRNA 4I13A 2GD9A 5HF2X 1KLKA 4KY8A 3CLBA 3F91A 3DRCA 3TQ9A 1D1GA 1U70A 1RD7A 4ELFA 4XT8A 4IXED 1YHOA 4OSGA 4RGCA 2W9TA 1DHIA 3FL9A 1RF7A 5FDAA 1PDBA 4X5HA 2AZNA 3CD2A 3CL9A 3GHCA 3SR5X 4CD2A 3S3VA 4LEKX 3M09A 4XE6X 1AO8A 3RG9A 4LAGX 4M7UA 5HT4A 1LY3A 1DRBA 3DFRA 1HFQA 4KJJA 2G6VA 1VDRA 3NXXA 4HOGA 3NZCX 3FRDX 3QGTA 3FL8A 3FQFA 1U72A 3SRQX 3UM6A 4ELHA 1OHKA 3NXTA 3HJ3A 3JWCA 3FQOA 4H97A 4KAKA 3F0SX 3F8YA 2D0KA 5ECCA 5HVEA 3QYOA 1DR1A 4PTHA 1JOMA 2O7PA 5HT5A 3R33A 4DDRA 4M6JA 4DFRA 3N0HA 2OBCA 1RA8A 2BLBA 1ZDRA 1DYRA 4Q6AA 4ELGA 3QLZA 1J3JA 2FZHA 1S3VA 4FHBA 1IA2A 4ELBA 4H95A 4QI9A 1RC4A 5JG0X 3FYWX 3F0QX 1DG8A 3ROAA 3EEMA 3IX9A 3EEKA 3EELA 3SA2A 1LY4A 1SEJA 1RA2A 4G3MA 1DR6A 1RX2A 1RA9A 2W3MA 4HOFA 3GHVA 3NZAX 1DYJA 3QLSA 1DLRA 1J3KA 3GI2A 4LAEX 4M2XA 1RX4A 1HFPA 3K2HA 1IA4A 5CCCA 1DHFA 2W9SA 4OR7A 5E8QA 3D84X 2CIGA 4HOEA 3NXYA 1M79A 5HF0X 3FQ0A 3QL3A 4H96A 2JYBA 3KJRA 3LG4A 1IA3A 3NXOA 4PSTA 5HSRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DIS A;  3OAF A;  3NZ6 X;  2HQP A;  1DRE A;  1DRH A;  1E26 A;  3IA4 A;  3I3R A;  2W3B A;  4KNE A;  4TU5 X;  4NX7 A;  2P4G A;  2LF1 A;  4LAH X;  1KMS A;  4KY4 A;  5HSU A;  4M6K A;  1S3W A;  2OIP A;  3GHW A;  4G8Z X;  3DG8 A;  1M7A A;  1RB3 A;  3F0V X;  4P68 A;  4P3R A;  3QG2 A;  3HBB A;  4QJZ D;  2KGK A;  4QLF A;  4X5F A;  1RH3 A;  1RX3 A;  3K47 A;  2D5N A;  3KFY A;  1RE7 A;  1DR2 A;  3EEJ A;  4I1N A;  3NZB X;  3EIG A;  7DFR A;  5EAJ A;  1DR5 A;  3UM5 A;  5CC9 A;  3DL6 A;  5DXV A;  5DFR A;  4PSY A;  3QLW A;  4KD7 A;  1RG7 A;  2W9G A;  3SRS X;  3F0X X;  3NTZ A;  3I8A X;  4KYA A;  5HQY A;  3UM8 A;  1CD2 A;  4G95 A;  3NZ9 X;  4XT6 A;  1DLS A;  4DPD A;  1DHJ A;  3Q1H A;  1DF7 A;  1DIU A;  3FYV X;  4DPH A;  2L28 A;  3FY9 X;  4PTJ A;  1DR4 A;  3GYF A;  3QLY A;  2BLA A;  1RX1 A;  2QK8 A;  4KJL A;  4KFJ A;  4EIL A;  1RX8 A;  4XRB A;  2INQ A;  3K45 A;  3D80 A;  1HFR A;  4KLX A;  4ECK A;  1DRF A;  2ITH A;  2ZZA A;  3DGA A;  3FS6 A;  3DAU A;  3ZPC A;  3SA1 A;  4XT7 A;  3IRM A;  1OHJ A;  4X5J A;  2XW7 A;  5HI6 A;  4FGH A;  2ANQ A;  3TD8 A;  2BLC A;  3NZD A;  3KY8 A;  3TQB A;  1DG7 A;  3S9U A;  1PD8 A;  1PD9 A;  5U27 A;  1AI9 A;  3TQ8 A;  3FQC A;  4GH8 A;  4IXF X;  1LUD A;  1RX6 A;  2HM9 A;  3RO9 A;  3M08 A;  3JW3 A;  4PSS A;  1RA1 A;  1RB2 A;  2W9H A;  2DRC A;  4PDJ A;  3OCH A;  1IA1 A;  1DAJ A;  4EJ1 A;  3SRU X;  2W3A A;  3DL5 A;  4XT4 A;  3F0U X;  3VCO A;  2CD2 A;  3JVX A;  3FQV A;  4QHV A;  1DR3 A;  4HA9 A;  4X5G A;  2C2T A;  3JWK A;  3INV A;  4H98 A;  8DFR A;  4QLG A;  2DHF A;  4KBN A;  1MVT A;  4M6L A;  3QFX A;  1CZ3 A;  5ECX A;  4P3Q A;  4X5I A;  3SH2 A;  2C2S A;  3FRA X;  5JA3 A;  1JUV A;  1S3U A;  3E0B A;  3KJS A;  4KM2 A;  4QJC A;  1RX5 A;  4QLE A;  1DDR A;  3EX8 A;  3JTW A;  3CSE A;  3SRW X;  2W3W A;  1J3I A;  5HUI A;  4Q67 A;  3IRO A;  1RA3 A;  3FRE X;  3QL0 A;  5U26 A;  1RX9 A;  3JSU A;  1DG5 A;  1DYH A;  3NXV A;  4KM0 A;  3FQZ A;  4M7V A;  3JWM A;  4EIZ A;  6DFR A;  4KL9 A;  2FZI A;  1RX7 A;  3S7A A;  4ELE A;  1S3Y A;  5HVB A;  3NRR A;  3F0B X;  3DAT A;  3ZPG A;  3SRR X;  1QZF A;  1KMV A;  3SAI A;  5HPB A;  3F8Z A;  3QLR A;  3NU0 A;  5HQZ A;  1M78 A;  1BOZ A;  3NXR A;  4NX6 A;  4XT5 A;  3FY8 X;  2FZJ A;  3FRF X;  3JW5 A;  4P66 A;  3SGY A;  1DDS A;  2ANO A;  3JWF A;  1DRA A;  3L3R A;  3QYL A;  1JOL A;  2B3Z A;  4DP3 A;  1VJ3 A;  1DR7 A;  4Q0E A;  4EIG A;  1AOE A;  4FGG A;  3TQA A;  3SQY X;  3QLX A;  3KGY A;  1MVS A;  4XEC X;  4HA7 A;  1TDR A;  2W3V A;  2H2Q A;  4KEB A;  2BL9 A;  4KJK A;  1U71 A;  3FRB X;  4Q0D A;  3IA5 A;  4IXG X;  1BZF A;  2HXV A;  3K74 A;  1DYI A;  3IRN A;  4I13 A;  2GD9 A;  5HF2 X;  1KLK A;  4KY8 A;  3CLB A;  3F91 A;  3DRC A;  3TQ9 A;  1D1G A;  1U70 A;  1RD7 A;  4ELF A;  4XT8 A;  4IXE D;  1YHO A;  4OSG A;  4RGC A;  2W9T A;  1DHI A;  3FL9 A;  1RF7 A;  5FDA A;  1PDB A;  4X5H A;  2AZN A;  3CD2 A;  3CL9 A;  3GHC A;  3SR5 X;  4CD2 A;  3S3V A;  4LEK X;  3M09 A;  4XE6 X;  1AO8 A;  3RG9 A;  4LAG X;  4M7U A;  5HT4 A;  1LY3 A;  1DRB A;  3DFR A;  1HFQ A;  4KJJ A;  2G6V A;  1VDR A;  3NXX A;  4HOG A;  3NZC X;  3FRD X;  3QGT A;  3FL8 A;  3FQF A;  1U72 A;  3SRQ X;  3UM6 A;  4ELH A;  1OHK A;  3NXT A;  3HJ3 A;  3JWC A;  3FQO A;  4H97 A;  4KAK A;  3F0S X;  3F8Y A;  2D0K A;  5ECC A;  5HVE A;  3QYO A;  1DR1 A;  4PTH A;  1JOM A;  2O7P A;  5HT5 A;  3R33 A;  4DDR A;  4M6J A;  4DFR A;  3N0H A;  2OBC A;  1RA8 A;  2BLB A;  1ZDR A;  1DYR A;  4Q6A A;  4ELG A;  3QLZ A;  1J3J A;  2FZH A;  1S3V A;  4FHB A;  1IA2 A;  4ELB A;  4H95 A;  4QI9 A;  1RC4 A;  5JG0 X;  3FYW X;  3F0Q X;  1DG8 A;  3ROA A;  3EEM A;  3IX9 A;  3EEK A;  3EEL A;  3SA2 A;  1LY4 A;  1SEJ A;  1RA2 A;  4G3M A;  1DR6 A;  1RX2 A;  1RA9 A;  2W3M A;  4HOF A;  3GHV A;  3NZA X;  1DYJ A;  3QLS A;  1DLR A;  1J3K A;  3GI2 A;  4LAE X;  4M2X A;  1RX4 A;  1HFP A;  3K2H A;  1IA4 A;  5CCC A;  1DHF A;  2W9S A;  4OR7 A;  5E8Q A;  3D84 X;  2CIG A;  4HOE A;  3NXY A;  1M79 A;  5HF0 X;  3FQ0 A;  3QL3 A;  4H96 A;  2JYB A;  3KJR A;  3LG4 A;  1IA3 A;  3NXO A;  4PST A;  5HSR A; 
#chains in the Genus database with same CATH topology
 1DIS A;  3OAF A;  3NZ6 X;  2HQP A;  1DRE A;  1DRH A;  1E26 A;  3IA4 A;  3I3R A;  2W3B A;  4KNE A;  4TU5 X;  4NX7 A;  2P4G A;  2LF1 A;  4LAH X;  1KMS A;  4KY4 A;  5HSU A;  4M6K A;  1S3W A;  2OIP A;  3GHW A;  4G8Z X;  3DG8 A;  1M7A A;  1RB3 A;  3F0V X;  4P68 A;  4P3R A;  3QG2 A;  3HBB A;  4QJZ D;  2KGK A;  4QLF A;  4X5F A;  1RH3 A;  1RX3 A;  3K47 A;  2D5N A;  3KFY A;  1RE7 A;  1DR2 A;  3EEJ A;  4I1N A;  3NZB X;  3EIG A;  7DFR A;  5EAJ A;  1DR5 A;  3UM5 A;  5CC9 A;  3DL6 A;  5DXV A;  5DFR A;  4PSY A;  3QLW A;  4KD7 A;  1RG7 A;  2W9G A;  3SRS X;  3F0X X;  3NTZ A;  3I8A X;  4KYA A;  5HQY A;  3UM8 A;  1CD2 A;  4G95 A;  3NZ9 X;  4XT6 A;  1DLS A;  4DPD A;  1DHJ A;  3Q1H A;  1DF7 A;  1DIU A;  3FYV X;  4DPH A;  2L28 A;  3FY9 X;  4PTJ A;  1DR4 A;  3GYF A;  3QLY A;  2BLA A;  1RX1 A;  2QK8 A;  4KJL A;  4KFJ A;  4EIL A;  1RX8 A;  4XRB A;  2INQ A;  3K45 A;  3D80 A;  1HFR A;  4KLX A;  4ECK A;  1DRF A;  2ITH A;  2ZZA A;  3DGA A;  3FS6 A;  3DAU A;  3ZPC A;  3SA1 A;  4XT7 A;  3IRM A;  1OHJ A;  4X5J A;  2XW7 A;  5HI6 A;  4FGH A;  2ANQ A;  3TD8 A;  2BLC A;  3NZD A;  3KY8 A;  3TQB A;  1DG7 A;  3S9U A;  1PD8 A;  1PD9 A;  5U27 A;  1AI9 A;  3TQ8 A;  3FQC A;  4GH8 A;  4IXF X;  1LUD A;  1RX6 A;  2HM9 A;  3RO9 A;  3M08 A;  3JW3 A;  4PSS A;  1RA1 A;  1RB2 A;  2W9H A;  2DRC A;  4PDJ A;  3OCH A;  1IA1 A;  1DAJ A;  4EJ1 A;  3SRU X;  2W3A A;  3DL5 A;  4XT4 A;  3F0U X;  3VCO A;  2CD2 A;  3JVX A;  3FQV A;  4QHV A;  1DR3 A;  4HA9 A;  4X5G A;  2C2T A;  3JWK A;  3INV A;  4H98 A;  8DFR A;  4QLG A;  2DHF A;  4KBN A;  1MVT A;  4M6L A;  3QFX A;  1CZ3 A;  5ECX A;  4P3Q A;  4X5I A;  3SH2 A;  2C2S A;  3FRA X;  5JA3 A;  1JUV A;  1S3U A;  3E0B A;  3KJS A;  4KM2 A;  4QJC A;  1RX5 A;  4QLE A;  1DDR A;  3EX8 A;  3JTW A;  3CSE A;  3SRW X;  2W3W A;  1J3I A;  5HUI A;  4Q67 A;  3IRO A;  1RA3 A;  3FRE X;  3QL0 A;  5U26 A;  1RX9 A;  3JSU A;  1DG5 A;  1DYH A;  3NXV A;  4KM0 A;  3FQZ A;  4M7V A;  3JWM A;  4EIZ A;  6DFR A;  4KL9 A;  2FZI A;  1RX7 A;  3S7A A;  4ELE A;  1S3Y A;  5HVB A;  3NRR A;  3F0B X;  3DAT A;  3ZPG A;  3SRR X;  1QZF A;  1KMV A;  3SAI A;  5HPB A;  3F8Z A;  3QLR A;  3NU0 A;  5HQZ A;  1M78 A;  1BOZ A;  3NXR A;  4NX6 A;  4XT5 A;  3FY8 X;  2FZJ A;  3FRF X;  3JW5 A;  4P66 A;  3SGY A;  1DDS A;  2ANO A;  3JWF A;  1DRA A;  3L3R A;  3QYL A;  1JOL A;  2B3Z A;  4DP3 A;  1VJ3 A;  1DR7 A;  4Q0E A;  4EIG A;  1AOE A;  4FGG A;  3TQA A;  3SQY X;  3QLX A;  3KGY A;  1MVS A;  4XEC X;  4HA7 A;  1TDR A;  2W3V A;  2H2Q A;  4KEB A;  2BL9 A;  4KJK A;  1U71 A;  3FRB X;  4Q0D A;  3IA5 A;  4IXG X;  1BZF A;  2HXV A;  3K74 A;  1DYI A;  3IRN A;  4I13 A;  2GD9 A;  5HF2 X;  1KLK A;  4KY8 A;  3CLB A;  3F91 A;  3DRC A;  3TQ9 A;  1D1G A;  1U70 A;  1RD7 A;  4ELF A;  4XT8 A;  4IXE D;  1YHO A;  4OSG A;  4RGC A;  2W9T A;  1DHI A;  3FL9 A;  1RF7 A;  5FDA A;  1PDB A;  4X5H A;  2AZN A;  3CD2 A;  3CL9 A;  3GHC A;  3SR5 X;  4CD2 A;  3S3V A;  4LEK X;  3M09 A;  4XE6 X;  1AO8 A;  3RG9 A;  4LAG X;  4M7U A;  5HT4 A;  1LY3 A;  1DRB A;  3DFR A;  1HFQ A;  4KJJ A;  2G6V A;  1VDR A;  3NXX A;  4HOG A;  3NZC X;  3FRD X;  3QGT A;  3FL8 A;  3FQF A;  1U72 A;  3SRQ X;  3UM6 A;  4ELH A;  1OHK A;  3NXT A;  3HJ3 A;  3JWC A;  3FQO A;  4H97 A;  4KAK A;  3F0S X;  3F8Y A;  2D0K A;  5ECC A;  5HVE A;  3QYO A;  1DR1 A;  4PTH A;  1JOM A;  2O7P A;  5HT5 A;  3R33 A;  4DDR A;  4M6J A;  4DFR A;  3N0H A;  2OBC A;  1RA8 A;  2BLB A;  1ZDR A;  1DYR A;  4Q6A A;  4ELG A;  3QLZ A;  1J3J A;  2FZH A;  1S3V A;  4FHB A;  1IA2 A;  4ELB A;  4H95 A;  4QI9 A;  1RC4 A;  5JG0 X;  3FYW X;  3F0Q X;  1DG8 A;  3ROA A;  3EEM A;  3IX9 A;  3EEK A;  3EEL A;  3SA2 A;  1LY4 A;  1SEJ A;  1RA2 A;  4G3M A;  1DR6 A;  1RX2 A;  1RA9 A;  2W3M A;  4HOF A;  3GHV A;  3NZA X;  1DYJ A;  3QLS A;  1DLR A;  1J3K A;  3GI2 A;  4LAE X;  4M2X A;  1RX4 A;  1HFP A;  3K2H A;  1IA4 A;  5CCC A;  1DHF A;  2W9S A;  4OR7 A;  5E8Q A;  3D84 X;  2CIG A;  4HOE A;  3NXY A;  1M79 A;  5HF0 X;  3FQ0 A;  3QL3 A;  4H96 A;  2JYB A;  3KJR A;  3LG4 A;  1IA3 A;  3NXO A;  4PST A;  5HSR A; 
#chains in the Genus database with same CATH homology
 1DIS A;  3OAF A;  3NZ6 X;  2HQP A;  1DRE A;  1DRH A;  1E26 A;  3IA4 A;  3I3R A;  2W3B A;  4KNE A;  4TU5 X;  4NX7 A;  2P4G A;  2LF1 A;  4LAH X;  1KMS A;  4KY4 A;  5HSU A;  4M6K A;  1S3W A;  2OIP A;  3GHW A;  4G8Z X;  3DG8 A;  1M7A A;  1RB3 A;  3F0V X;  4P68 A;  4P3R A;  3QG2 A;  3HBB A;  4QJZ D;  2KGK A;  4QLF A;  4X5F A;  1RH3 A;  1RX3 A;  3K47 A;  2D5N A;  3KFY A;  1RE7 A;  1DR2 A;  3EEJ A;  4I1N A;  3NZB X;  3EIG A;  7DFR A;  5EAJ A;  1DR5 A;  3UM5 A;  5CC9 A;  3DL6 A;  5DXV A;  5DFR A;  4PSY A;  3QLW A;  4KD7 A;  1RG7 A;  2W9G A;  3SRS X;  3F0X X;  3NTZ A;  3I8A X;  4KYA A;  5HQY A;  3UM8 A;  1CD2 A;  4G95 A;  3NZ9 X;  4XT6 A;  1DLS A;  4DPD A;  1DHJ A;  3Q1H A;  1DF7 A;  1DIU A;  3FYV X;  4DPH A;  2L28 A;  3FY9 X;  4PTJ A;  1DR4 A;  3GYF A;  3QLY A;  2BLA A;  1RX1 A;  2QK8 A;  4KJL A;  4KFJ A;  4EIL A;  1RX8 A;  4XRB A;  2INQ A;  3K45 A;  3D80 A;  1HFR A;  4KLX A;  4ECK A;  1DRF A;  2ITH A;  2ZZA A;  3DGA A;  3FS6 A;  3DAU A;  3ZPC A;  3SA1 A;  4XT7 A;  3IRM A;  1OHJ A;  4X5J A;  2XW7 A;  5HI6 A;  4FGH A;  2ANQ A;  3TD8 A;  2BLC A;  3NZD A;  3KY8 A;  3TQB A;  1DG7 A;  3S9U A;  1PD8 A;  1PD9 A;  5U27 A;  1AI9 A;  3TQ8 A;  3FQC A;  4GH8 A;  4IXF X;  1LUD A;  1RX6 A;  2HM9 A;  3RO9 A;  3M08 A;  3JW3 A;  4PSS A;  1RA1 A;  1RB2 A;  2W9H A;  2DRC A;  4PDJ A;  3OCH A;  1IA1 A;  1DAJ A;  4EJ1 A;  3SRU X;  2W3A A;  3DL5 A;  4XT4 A;  3F0U X;  3VCO A;  2CD2 A;  3JVX A;  3FQV A;  4QHV A;  1DR3 A;  4HA9 A;  4X5G A;  2C2T A;  3JWK A;  3INV A;  4H98 A;  8DFR A;  4QLG A;  2DHF A;  4KBN A;  1MVT A;  4M6L A;  3QFX A;  1CZ3 A;  5ECX A;  4P3Q A;  4X5I A;  3SH2 A;  2C2S A;  3FRA X;  5JA3 A;  1JUV A;  1S3U A;  3E0B A;  3KJS A;  4KM2 A;  4QJC A;  1RX5 A;  4QLE A;  1DDR A;  3EX8 A;  3JTW A;  3CSE A;  3SRW X;  2W3W A;  1J3I A;  5HUI A;  4Q67 A;  3IRO A;  1RA3 A;  3FRE X;  3QL0 A;  5U26 A;  1RX9 A;  3JSU A;  1DG5 A;  1DYH A;  3NXV A;  4KM0 A;  3FQZ A;  4M7V A;  3JWM A;  4EIZ A;  6DFR A;  4KL9 A;  2FZI A;  1RX7 A;  3S7A A;  4ELE A;  1S3Y A;  5HVB A;  3NRR A;  3F0B X;  3DAT A;  3ZPG A;  3SRR X;  1QZF A;  1KMV A;  3SAI A;  5HPB A;  3F8Z A;  3QLR A;  3NU0 A;  5HQZ A;  1M78 A;  1BOZ A;  3NXR A;  4NX6 A;  4XT5 A;  3FY8 X;  2FZJ A;  3FRF X;  3JW5 A;  4P66 A;  3SGY A;  1DDS A;  2ANO A;  3JWF A;  1DRA A;  3L3R A;  3QYL A;  1JOL A;  2B3Z A;  4DP3 A;  1VJ3 A;  1DR7 A;  4Q0E A;  4EIG A;  1AOE A;  4FGG A;  3TQA A;  3SQY X;  3QLX A;  3KGY A;  1MVS A;  4XEC X;  4HA7 A;  1TDR A;  2W3V A;  2H2Q A;  4KEB A;  2BL9 A;  4KJK A;  1U71 A;  3FRB X;  4Q0D A;  3IA5 A;  4IXG X;  1BZF A;  2HXV A;  3K74 A;  1DYI A;  3IRN A;  4I13 A;  2GD9 A;  5HF2 X;  1KLK A;  4KY8 A;  3CLB A;  3F91 A;  3DRC A;  3TQ9 A;  1D1G A;  1U70 A;  1RD7 A;  4ELF A;  4XT8 A;  4IXE D;  1YHO A;  4OSG A;  4RGC A;  2W9T A;  1DHI A;  3FL9 A;  1RF7 A;  5FDA A;  1PDB A;  4X5H A;  2AZN A;  3CD2 A;  3CL9 A;  3GHC A;  3SR5 X;  4CD2 A;  3S3V A;  4LEK X;  3M09 A;  4XE6 X;  1AO8 A;  3RG9 A;  4LAG X;  4M7U A;  5HT4 A;  1LY3 A;  1DRB A;  3DFR A;  1HFQ A;  4KJJ A;  2G6V A;  1VDR A;  3NXX A;  4HOG A;  3NZC X;  3FRD X;  3QGT A;  3FL8 A;  3FQF A;  1U72 A;  3SRQ X;  3UM6 A;  4ELH A;  1OHK A;  3NXT A;  3HJ3 A;  3JWC A;  3FQO A;  4H97 A;  4KAK A;  3F0S X;  3F8Y A;  2D0K A;  5ECC A;  5HVE A;  3QYO A;  1DR1 A;  4PTH A;  1JOM A;  2O7P A;  5HT5 A;  3R33 A;  4DDR A;  4M6J A;  4DFR A;  3N0H A;  2OBC A;  1RA8 A;  2BLB A;  1ZDR A;  1DYR A;  4Q6A A;  4ELG A;  3QLZ A;  1J3J A;  2FZH A;  1S3V A;  4FHB A;  1IA2 A;  4ELB A;  4H95 A;  4QI9 A;  1RC4 A;  5JG0 X;  3FYW X;  3F0Q X;  1DG8 A;  3ROA A;  3EEM A;  3IX9 A;  3EEK A;  3EEL A;  3SA2 A;  1LY4 A;  1SEJ A;  1RA2 A;  4G3M A;  1DR6 A;  1RX2 A;  1RA9 A;  2W3M A;  4HOF A;  3GHV A;  3NZA X;  1DYJ A;  3QLS A;  1DLR A;  1J3K A;  3GI2 A;  4LAE X;  4M2X A;  1RX4 A;  1HFP A;  3K2H A;  1IA4 A;  5CCC A;  1DHF A;  2W9S A;  4OR7 A;  5E8Q A;  3D84 X;  2CIG A;  4HOE A;  3NXY A;  1M79 A;  5HF0 X;  3FQ0 A;  3QL3 A;  4H96 A;  2JYB A;  3KJR A;  3LG4 A;  1IA3 A;  3NXO A;  4PST A;  5HSR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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