1R1OA

Amino acid sulfonamides as transition-state analogue inhibitors of arginase
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Arginase 1
publication title Design of Amino Acid Sulfonamides as Transition-State Analogue Inhibitors of Arginase
pubmed doi rcsb
source organism Rattus norvegicus
total genus 108
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2003-09-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 1r1oA00
3GN0A 3KV2A 3LP7A 1WVAA 3RLAA 4RHQA 2CEVA 3E6VA 3DJ8A 1ZPEA 4I06A 3MJLA 3SL1A 2EF5A 4IU1A 2EF4A 3LHLA 4GSMA 4Q3RC 4HXQA 4FCIA 1GQ6A 1T5GA 4HWWA 3SKKA 1P8QA 4IXVA 3PZLA 3M1RA 2EIVA 4G3HA 4HZEA 4MYFA 1T4TA 3TF3A 4MYKA 2AEBA 1T4RA 1TBJA 1CEVA 4FCKA 4RHMA 4RHJA 4Q3VA 1HQFA 4Q42A 1TA1A 4IXUA 2ZAVA 4Q3UA 4IE3A 4RHIA 3NIQA 3LP4A 4Q3SA 3THHA 4GSZA 1ZPGA 1HQ5A 1T5FA 1P8MA 1P8PA 2RLAA 4IU5A 4RHKA 1WOGA 4IU4A 4IE2A 1WVBA 1P8RA 1T4SA 4RLAA 3E9BA 1D3VA 2PHAA 1T4PA 4Q3PA 4RHLA 2A0MA 3THEA 3MFWA 1TBHA 4MXRA 3E8ZA 3E6KA 3SJTA 4ITYA 3NIOA 1GQ7A 5RLAA 3MMRA 1R1OA 5HJAA 4MYLA 4Q3TA 3MFVA 5HJ9A 3THJA 1P8OA 3SL0A 4GWCA 4Q41A 1HQGA 1P8SA 1HQXA 1XFKA 4DZ4A 3CEVA 2PHOA 4GWDA 1PQ3A 2PLLA 4GSVA 4Q3QA 1WOIA 1WOHA 1HQHA 3E8QA 1TBLA 3NIPA 3GMZA 4IE1A 4Q3RA 1RLAA 4CEVA 1P8NA 4MYNA 4IU0A 5CEVA 3F80A 4Q40A 3TH7A
chains in the Genus database with same CATH superfamily
3GN0A 4QA2A 3KV2A 4QA1A 5EFHA 5FCWA 3LP7A 1WVAA 4CBTA 3C0YA 5G3WA 5G0YA 4RHQA 3RLAA 3MZ7A 5THVA 3Q9FA 2CEVA 3E6VA 3EZTA 3MZ6A 5THUA 3Q9BA 3DJ8A 1ZPEA 2VQMA 5D1CA 3F07A 4I06A 5EEIA 5EEFA 3MJLA 2VQVA 3MENA 5EENA 5G1CA 3SL1A 2EF5A 4IU1A 2EF4A 3LHLA 4ZUOA 2VQOA 4GSMA 4Q3RC 4HXQA 4ZUNA 2GH6A 4FCIA 1GQ6A 5EFNA 3F0RA 4QA0A 1T5GA 4HWWA 3SKKA 5EFBD 4ZUPA 5DC5A 1P8QA 5D1BA 4IXVA 5G0JA 5G0IA 3MZ3A 5DC6A 4BZ8A 3PZLA 4CBYA 3EW8A 3M1RA 2EIVA 4G3HA 4HZEA 4MYFA 1T4TA 5THSA 1ZZ0A 3TF3A 4MYKA 2AEBA 1T4RA 1TBJA 1CEVA 1ZZ1A 3Q9EA 4FCKA 4RHMA 1T67A 2V5WA 2VQQA 4RN0A 4BZ9A 5EEMA 4RHJA 4ZURA 2VQWG 4Q3VA 5G0GA 4ZUQA 3MAXA 1HQFA 4Q42A 1TA1A 5JI5A 5G11A 4IXUA 2ZAVA 3C10A 4LY1A 4Q3UA 3EZPA 5A2SA 4IE3A 4RHIA 1T64A 3NIQA 4LXZA 3LP4A 4Q3SA 3THHA 3MZ4A 1C3PA 4QA5A 5DC8A 4BKXB 1C3RA 4GSZA 3SFFA 1ZPGA 5ICNB 1HQ5A 1T5FA 5G1AA 5EEKA 1P8MA 1P8PA 2RLAA 4IU5A 5THTA 4RN1A 4A69A 4RHKA 1WOGA 1T69A 4IU4A 4IE2A 5DC7A 1WVBA 1P8RA 5EF8A 4BZ5A 1T4SA 5BWZA 4RLAA 3E9BA 1D3VA 2PHAA 1T4PA 4QA3A 4Q3PA 4RHLA 2A0MA 3THEA 3MFWA 1TBHA 4MXRA 3E8ZA 5EFGA 5D1DA 3E6KA 3SJTA 4ITYA 2VQJA 3NIOA 1GQ7A 5RLAA 3MMRA 1R1OA 5HJAA 5LI3A 4MYLA 4Q3TA 5EFKB 3MFVA 3SFHA 5EFJD 5HJ9A 3THJA 1P8OA 3RQDA 3SL0A 4GWCA 4BZ6A 4Q41A 1HQGA 1P8SA 1ZZ3A 4BZ7A 5G0HA 3C0ZA 1VKGA 3ZNRA 1HQXA 1XFKA 5G1BA 5IWGA 5G13A 5G17A 3Q9CA 4DZ4A 3CEVA 2PHOA 4GWDA 1C3SA 1PQ3A 2PLLA 4GSVA 4Q3QA 4RN2A 5FUEA 5G10A 1WOIA 1WOHA 2VCGA 1HQHA 1W22A 3E8QA 1TBLA 3F06A 4QA4A 3NIPA 5IX0A 4QA7A 3GMZA 3EWFA 4IE1A 4Q3RA 5EF7A 1RLAA 4ZUMA 4CEVA 3ZNSA 1P8NA 4MYNA 4CQFA 4QA6A 4IU0A 5CEVA 5G0XA 2V5XA 3F80A 5G12A 4Q40A 3TH7A
chains in the Genus database with same CATH topology
3GN0A 3KV2A 3LP7A 1WVAA 3RLAA 4RHQA 2CEVA 3E6VA 3DJ8A 1ZPEA 4I06A 3MJLA 3SL1A 2EF5A 4IU1A 2EF4A 3LHLA 4GSMA 4Q3RC 4HXQA 4FCIA 1GQ6A 1T5GA 4HWWA 3SKKA 1P8QA 4IXVA 3PZLA 3M1RA 2EIVA 4G3HA 4HZEA 4MYFA 1T4TA 3TF3A 4MYKA 2AEBA 1T4RA 1TBJA 1CEVA 4FCKA 4RHMA 4RHJA 4Q3VA 1HQFA 4Q42A 1TA1A 4IXUA 2ZAVA 4Q3UA 4IE3A 4RHIA 3NIQA 3LP4A 4Q3SA 3THHA 4GSZA 1ZPGA 1HQ5A 1T5FA 1P8MA 1P8PA 2RLAA 4IU5A 4RHKA 1WOGA 4IU4A 4IE2A 1WVBA 1P8RA 1T4SA 4RLAA 3E9BA 1D3VA 2PHAA 1T4PA 4Q3PA 4RHLA 2A0MA 3THEA 3MFWA 1TBHA 4MXRA 3E8ZA 3E6KA 3SJTA 4ITYA 3NIOA 1GQ7A 5RLAA 3MMRA 1R1OA 5HJAA 4MYLA 4Q3TA 3MFVA 5HJ9A 3THJA 1P8OA 3SL0A 4GWCA 4Q41A 1HQGA 1P8SA 1HQXA 1XFKA 4DZ4A 3CEVA 2PHOA 4GWDA 1PQ3A 2PLLA 4GSVA 4Q3QA 1WOIA 1WOHA 1HQHA 3E8QA 1TBLA 3NIPA 3GMZA 4IE1A 4Q3RA 1RLAA 4CEVA 1P8NA 4MYNA 4IU0A 5CEVA 3F80A 4Q40A 3TH7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GN0 A;  3KV2 A;  3LP7 A;  1WVA A;  3RLA A;  4RHQ A;  2CEV A;  3E6V A;  3DJ8 A;  1ZPE A;  4I06 A;  3MJL A;  3SL1 A;  2EF5 A;  4IU1 A;  2EF4 A;  3LHL A;  4GSM A;  4Q3R C;  4HXQ A;  4FCI A;  1GQ6 A;  1T5G A;  4HWW A;  3SKK A;  1P8Q A;  4IXV A;  3PZL A;  3M1R A;  2EIV A;  4G3H A;  4HZE A;  4MYF A;  1T4T A;  3TF3 A;  4MYK A;  2AEB A;  1T4R A;  1TBJ A;  1CEV A;  4FCK A;  4RHM A;  4RHJ A;  4Q3V A;  1HQF A;  4Q42 A;  1TA1 A;  4IXU A;  2ZAV A;  4Q3U A;  4IE3 A;  4RHI A;  3NIQ A;  3LP4 A;  4Q3S A;  3THH A;  4GSZ A;  1ZPG A;  1HQ5 A;  1T5F A;  1P8M A;  1P8P A;  2RLA A;  4IU5 A;  4RHK A;  1WOG A;  4IU4 A;  4IE2 A;  1WVB A;  1P8R A;  1T4S A;  4RLA A;  3E9B A;  1D3V A;  2PHA A;  1T4P A;  4Q3P A;  4RHL A;  2A0M A;  3THE A;  3MFW A;  1TBH A;  4MXR A;  3E8Z A;  3E6K A;  3SJT A;  4ITY A;  3NIO A;  1GQ7 A;  5RLA A;  3MMR A;  1R1O A;  5HJA A;  4MYL A;  4Q3T A;  3MFV A;  5HJ9 A;  3THJ A;  1P8O A;  3SL0 A;  4GWC A;  4Q41 A;  1HQG A;  1P8S A;  1HQX A;  1XFK A;  4DZ4 A;  3CEV A;  2PHO A;  4GWD A;  1PQ3 A;  2PLL A;  4GSV A;  4Q3Q A;  1WOI A;  1WOH A;  1HQH A;  3E8Q A;  1TBL A;  3NIP A;  3GMZ A;  4IE1 A;  4Q3R A;  1RLA A;  4CEV A;  1P8N A;  4MYN A;  4IU0 A;  5CEV A;  3F80 A;  4Q40 A;  3TH7 A; 
#chains in the Genus database with same CATH topology
 3GN0 A;  4QA2 A;  3KV2 A;  4QA1 A;  5EFH A;  5FCW A;  3LP7 A;  1WVA A;  4CBT A;  3C0Y A;  5G3W A;  5G0Y A;  4RHQ A;  3RLA A;  3MZ7 A;  5THV A;  3Q9F A;  2CEV A;  3E6V A;  3EZT A;  3MZ6 A;  5THU A;  3Q9B A;  3DJ8 A;  1ZPE A;  2VQM A;  5D1C A;  3F07 A;  4I06 A;  5EEI A;  5EEF A;  3MJL A;  2VQV A;  3MEN A;  5EEN A;  5G1C A;  3SL1 A;  2EF5 A;  4IU1 A;  2EF4 A;  3LHL A;  4ZUO A;  2VQO A;  4GSM A;  4Q3R C;  4HXQ A;  4ZUN A;  2GH6 A;  4FCI A;  1GQ6 A;  5EFN A;  3F0R A;  4QA0 A;  1T5G A;  4HWW A;  3SKK A;  5EFB D;  4ZUP A;  5DC5 A;  1P8Q A;  5D1B A;  4IXV A;  5G0J A;  5G0I A;  3MZ3 A;  5DC6 A;  4BZ8 A;  3PZL A;  4CBY A;  3EW8 A;  3M1R A;  2EIV A;  4G3H A;  4HZE A;  4MYF A;  1T4T A;  5THS A;  1ZZ0 A;  3TF3 A;  4MYK A;  2AEB A;  1T4R A;  1TBJ A;  1CEV A;  1ZZ1 A;  3Q9E A;  4FCK A;  4RHM A;  1T67 A;  2V5W A;  2VQQ A;  4RN0 A;  4BZ9 A;  5EEM A;  4RHJ A;  4ZUR A;  2VQW G;  4Q3V A;  5G0G A;  4ZUQ A;  3MAX A;  1HQF A;  4Q42 A;  1TA1 A;  5JI5 A;  5G11 A;  4IXU A;  2ZAV A;  3C10 A;  4LY1 A;  4Q3U A;  3EZP A;  5A2S A;  4IE3 A;  4RHI A;  1T64 A;  3NIQ A;  4LXZ A;  3LP4 A;  4Q3S A;  3THH A;  3MZ4 A;  1C3P A;  4QA5 A;  5DC8 A;  4BKX B;  1C3R A;  4GSZ A;  3SFF A;  1ZPG A;  5ICN B;  1HQ5 A;  1T5F A;  5G1A A;  5EEK A;  1P8M A;  1P8P A;  2RLA A;  4IU5 A;  5THT A;  4RN1 A;  4A69 A;  4RHK A;  1WOG A;  1T69 A;  4IU4 A;  4IE2 A;  5DC7 A;  1WVB A;  1P8R A;  5EF8 A;  4BZ5 A;  1T4S A;  5BWZ A;  4RLA A;  3E9B A;  1D3V A;  2PHA A;  1T4P A;  4QA3 A;  4Q3P A;  4RHL A;  2A0M A;  3THE A;  3MFW A;  1TBH A;  4MXR A;  3E8Z A;  5EFG A;  5D1D A;  3E6K A;  3SJT A;  4ITY A;  2VQJ A;  3NIO A;  1GQ7 A;  5RLA A;  3MMR A;  1R1O A;  5HJA A;  5LI3 A;  4MYL A;  4Q3T A;  5EFK B;  3MFV A;  3SFH A;  5EFJ D;  5HJ9 A;  3THJ A;  1P8O A;  3RQD A;  3SL0 A;  4GWC A;  4BZ6 A;  4Q41 A;  1HQG A;  1P8S A;  1ZZ3 A;  4BZ7 A;  5G0H A;  3C0Z A;  1VKG A;  3ZNR A;  1HQX A;  1XFK A;  5G1B A;  5IWG A;  5G13 A;  5G17 A;  3Q9C A;  4DZ4 A;  3CEV A;  2PHO A;  4GWD A;  1C3S A;  1PQ3 A;  2PLL A;  4GSV A;  4Q3Q A;  4RN2 A;  5FUE A;  5G10 A;  1WOI A;  1WOH A;  2VCG A;  1HQH A;  1W22 A;  3E8Q A;  1TBL A;  3F06 A;  4QA4 A;  3NIP A;  5IX0 A;  4QA7 A;  3GMZ A;  3EWF A;  4IE1 A;  4Q3R A;  5EF7 A;  1RLA A;  4ZUM A;  4CEV A;  3ZNS A;  1P8N A;  4MYN A;  4CQF A;  4QA6 A;  4IU0 A;  5CEV A;  5G0X A;  2V5X A;  3F80 A;  5G12 A;  4Q40 A;  3TH7 A; 
#chains in the Genus database with same CATH homology
 3GN0 A;  3KV2 A;  3LP7 A;  1WVA A;  3RLA A;  4RHQ A;  2CEV A;  3E6V A;  3DJ8 A;  1ZPE A;  4I06 A;  3MJL A;  3SL1 A;  2EF5 A;  4IU1 A;  2EF4 A;  3LHL A;  4GSM A;  4Q3R C;  4HXQ A;  4FCI A;  1GQ6 A;  1T5G A;  4HWW A;  3SKK A;  1P8Q A;  4IXV A;  3PZL A;  3M1R A;  2EIV A;  4G3H A;  4HZE A;  4MYF A;  1T4T A;  3TF3 A;  4MYK A;  2AEB A;  1T4R A;  1TBJ A;  1CEV A;  4FCK A;  4RHM A;  4RHJ A;  4Q3V A;  1HQF A;  4Q42 A;  1TA1 A;  4IXU A;  2ZAV A;  4Q3U A;  4IE3 A;  4RHI A;  3NIQ A;  3LP4 A;  4Q3S A;  3THH A;  4GSZ A;  1ZPG A;  1HQ5 A;  1T5F A;  1P8M A;  1P8P A;  2RLA A;  4IU5 A;  4RHK A;  1WOG A;  4IU4 A;  4IE2 A;  1WVB A;  1P8R A;  1T4S A;  4RLA A;  3E9B A;  1D3V A;  2PHA A;  1T4P A;  4Q3P A;  4RHL A;  2A0M A;  3THE A;  3MFW A;  1TBH A;  4MXR A;  3E8Z A;  3E6K A;  3SJT A;  4ITY A;  3NIO A;  1GQ7 A;  5RLA A;  3MMR A;  1R1O A;  5HJA A;  4MYL A;  4Q3T A;  3MFV A;  5HJ9 A;  3THJ A;  1P8O A;  3SL0 A;  4GWC A;  4Q41 A;  1HQG A;  1P8S A;  1HQX A;  1XFK A;  4DZ4 A;  3CEV A;  2PHO A;  4GWD A;  1PQ3 A;  2PLL A;  4GSV A;  4Q3Q A;  1WOI A;  1WOH A;  1HQH A;  3E8Q A;  1TBL A;  3NIP A;  3GMZ A;  4IE1 A;  4Q3R A;  1RLA A;  4CEV A;  1P8N A;  4MYN A;  4IU0 A;  5CEV A;  3F80 A;  4Q40 A;  3TH7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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