2RLAA

Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
303
structure length
303
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVPLTLSCFGTKR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords ARGINASE
publication title Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
pubmed doi rcsb
total genus 98
structure length 303
sequence length 303
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 1997-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 2rlaA00
1P8OA 2PLLA 3LHLA 4DZ4A 1P8NA 3GN0A 4IU5A 1XFKA 1P8QA 1T5GA 4MYLA 2ZAVA 1P8RA 1TBJA 1HQ5A 1TBLA 2CEVA 1WVAA 3GMZA 4ITYA 1TBHA 3DJ8A 3TH7A 1WOHA 4CEVA 3SJTA 1T4RA 4HWWA 1GQ7A 1PQ3A 1P8PA 3SL1A 5RLAA 2PHAA 1ZPEA 2EF4A 3MMRA 4Q3UA 2AEBA 4Q3TA 3SKKA 2A0MA 4MYKA 4FCIA 3MJLA 3THHA 1P8SA 2EF5A 4IU4A 3THEA 3KV2A 4Q3VA 5CEVA 4RHQA 4IXUA 4HZEA 4IE3A 4Q3QA 3PZLA 4GSZA 3E9BA 3E8ZA 3E6VA 3TF3A 4MYNA 4GWDA 4RHKA 1T5FA 2RLAA 1T4TA 4IE2A 4IU1A 4GWCA 3M1RA 1HQFA 4Q42A 4Q41A 1WOIA 3E6KA 4IE1A 2EIVA 3SL0A 5HJ9A 4Q40A 3RLAA 1WVBA 4Q3PA 4IU0A 4FCKA 3NIOA 4GSVA 4Q3RA 5HJAA 1T4PA 3MFVA 3E8QA 1CEVA 4RHMA 4RHJA 1HQXA 3NIPA 3NIQA 1TA1A 4RHIA 1WOGA 4MYFA 4GSMA 3MFWA 1HQGA 1ZPGA 1RLAA 4Q3RC 1T4SA 4MXRA 4RLAA 2PHOA 3LP4A 4I06A 4HXQA 3F80A 3LP7A 4G3HA 1P8MA 4Q3SA 1D3VA 4IXVA 4RHLA 1HQHA 1GQ6A 3CEVA 3THJA 1R1OA
chains in the Genus database with same CATH superfamily
1P8OA 4RN1A 2PLLA 3LHLA 5BWZA 4DZ4A 5EFBD 1P8NA 3GN0A 5EEIA 4LY1A 5EFJD 4A69A 5G0XA 4IU5A 1XFKA 1P8QA 1T5GA 1T67A 4MYLA 3ZNSA 2ZAVA 3EZTA 1P8RA 1TBJA 1HQ5A 1TBLA 2CEVA 3F0RA 5IWGA 4BZ5A 5EEMA 1WVAA 2VQMA 3GMZA 4ITYA 1W22A 1TBHA 5EEKA 3DJ8A 4BZ6A 3Q9CA 3TH7A 1WOHA 5EF8A 5G11A 1C3SA 4CEVA 3SJTA 4QA0A 2VQWG 5THUA 1T4RA 4HWWA 1GQ7A 1PQ3A 1GQ6A 5A2SA 3MZ7A 1P8PA 4QA3A 3SL1A 5RLAA 2PHAA 1ZPEA 3MZ3A 2EF4A 3Q9BA 3MMRA 1C3RA 5IX0A 4Q3UA 2AEBA 3MAXA 1ZZ0A 3F06A 4Q3TA 4CQFA 3SKKA 4RN2A 2A0MA 4MYKA 4FCIA 3MJLA 2V5XA 4ZUMA 1P8SA 2EF5A 5G13A 4IU4A 3THHA 4LXZA 3THEA 3KV2A 4Q3VA 5CEVA 1VKGA 5D1CA 4RHQA 5G1AA 4IXUA 5G10A 3MZ6A 4HZEA 4IE3A 4Q3QA 3PZLA 5DC8A 4GSZA 5THSA 4ZUQA 3E9BA 3E8ZA 3E6VA 3TF3A 4MYNA 4GWDA 4CBYA 5G0YA 4QA1A 1T5FA 4RHKA 4RN0A 1T69A 1T4TA 2RLAA 4IE2A 3MENA 5EF7A 3RQDA 2VQVA 4QA7A 4IU1A 4GWCA 2VCGA 5EEFA 5EENA 3M1RA 1HQFA 3EW8A 4Q42A 5G3WA 4Q41A 1WOIA 3E6KA 4QA4A 3C0ZA 5EFGA 5FUEA 4IE1A 5G0HA 2EIVA 5G12A 3SL0A 5HJ9A 5THVA 5ICNB 2VQJA 4Q40A 5G1CA 3RLAA 1WVBA 4Q3PA 4BZ7A 3EZPA 5DC7A 3F07A 3EWFA 4IU0A 3MZ4A 4FCKA 5LI3A 5G17A 3NIOA 4GSVA 4Q3RA 4QA2A 3ZNRA 5JI5A 4ZURA 5HJAA 1T4PA 3MFVA 5DC6A 3E8QA 5G0GA 2V5WA 1ZZ1A 4BZ9A 1CEVA 4RHMA 4RHJA 1HQXA 5EFHA 5EFKB 3NIPA 3NIQA 1TA1A 4RHIA 5FCWA 5D1BA 5THTA 1WOGA 4MYFA 4GSMA 2GH6A 3C10A 3MFWA 1HQGA 5G0JA 1ZPGA 1RLAA 4Q3RC 5G1BA 1T4SA 3C0YA 5G0IA 1T64A 2VQOA 4ZUOA 3SFFA 3Q9FA 4MXRA 4RLAA 2PHOA 4ZUPA 3LP4A 4BZ8A 1ZZ3A 4I06A 4ZUNA 4HXQA 4BKXB 4CBTA 3SFHA 5DC5A 3F80A 3LP7A 4QA5A 5EFNA 4G3HA 2VQQA 5D1DA 1P8MA 4Q3SA 1D3VA 4IXVA 4RHLA 1HQHA 3Q9EA 1C3PA 3CEVA 4QA6A 3THJA 1R1OA
chains in the Genus database with same CATH topology
1P8OA 2PLLA 3LHLA 4DZ4A 1P8NA 3GN0A 4IU5A 1XFKA 1P8QA 1T5GA 4MYLA 2ZAVA 1P8RA 1TBJA 1HQ5A 1TBLA 2CEVA 1WVAA 3GMZA 4ITYA 1TBHA 3DJ8A 3TH7A 1WOHA 4CEVA 3SJTA 1T4RA 4HWWA 1GQ7A 1PQ3A 1P8PA 3SL1A 5RLAA 2PHAA 1ZPEA 2EF4A 3MMRA 4Q3UA 2AEBA 4Q3TA 3SKKA 2A0MA 4MYKA 4FCIA 3MJLA 3THHA 1P8SA 2EF5A 4IU4A 3THEA 3KV2A 4Q3VA 5CEVA 4RHQA 4IXUA 4HZEA 4IE3A 4Q3QA 3PZLA 4GSZA 3E9BA 3E8ZA 3E6VA 3TF3A 4MYNA 4GWDA 4RHKA 1T5FA 2RLAA 1T4TA 4IE2A 4IU1A 4GWCA 3M1RA 1HQFA 4Q42A 4Q41A 1WOIA 3E6KA 4IE1A 2EIVA 3SL0A 5HJ9A 4Q40A 3RLAA 1WVBA 4Q3PA 4IU0A 4FCKA 3NIOA 4GSVA 4Q3RA 5HJAA 1T4PA 3MFVA 3E8QA 1CEVA 4RHMA 4RHJA 1HQXA 3NIPA 3NIQA 1TA1A 4RHIA 1WOGA 4MYFA 4GSMA 3MFWA 1HQGA 1ZPGA 1RLAA 4Q3RC 1T4SA 4MXRA 4RLAA 2PHOA 3LP4A 4I06A 4HXQA 3F80A 3LP7A 4G3HA 1P8MA 4Q3SA 1D3VA 4IXVA 4RHLA 1HQHA 1GQ6A 3CEVA 3THJA 1R1OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P8O A;  2PLL A;  3LHL A;  4DZ4 A;  1P8N A;  3GN0 A;  4IU5 A;  1XFK A;  1P8Q A;  1T5G A;  4MYL A;  2ZAV A;  1P8R A;  1TBJ A;  1HQ5 A;  1TBL A;  2CEV A;  1WVA A;  3GMZ A;  4ITY A;  1TBH A;  3DJ8 A;  3TH7 A;  1WOH A;  4CEV A;  3SJT A;  1T4R A;  4HWW A;  1GQ7 A;  1PQ3 A;  1P8P A;  3SL1 A;  5RLA A;  2PHA A;  1ZPE A;  2EF4 A;  3MMR A;  4Q3U A;  2AEB A;  4Q3T A;  3SKK A;  2A0M A;  4MYK A;  4FCI A;  3MJL A;  3THH A;  1P8S A;  2EF5 A;  4IU4 A;  3THE A;  3KV2 A;  4Q3V A;  5CEV A;  4RHQ A;  4IXU A;  4HZE A;  4IE3 A;  4Q3Q A;  3PZL A;  4GSZ A;  3E9B A;  3E8Z A;  3E6V A;  3TF3 A;  4MYN A;  4GWD A;  4RHK A;  1T5F A;  2RLA A;  1T4T A;  4IE2 A;  4IU1 A;  4GWC A;  3M1R A;  1HQF A;  4Q42 A;  4Q41 A;  1WOI A;  3E6K A;  4IE1 A;  2EIV A;  3SL0 A;  5HJ9 A;  4Q40 A;  3RLA A;  1WVB A;  4Q3P A;  4IU0 A;  4FCK A;  3NIO A;  4GSV A;  4Q3R A;  5HJA A;  1T4P A;  3MFV A;  3E8Q A;  1CEV A;  4RHM A;  4RHJ A;  1HQX A;  3NIP A;  3NIQ A;  1TA1 A;  4RHI A;  1WOG A;  4MYF A;  4GSM A;  3MFW A;  1HQG A;  1ZPG A;  1RLA A;  4Q3R C;  1T4S A;  4MXR A;  4RLA A;  2PHO A;  3LP4 A;  4I06 A;  4HXQ A;  3F80 A;  3LP7 A;  4G3H A;  1P8M A;  4Q3S A;  1D3V A;  4IXV A;  4RHL A;  1HQH A;  1GQ6 A;  3CEV A;  3THJ A;  1R1O A; 
#chains in the Genus database with same CATH topology
 1P8O A;  4RN1 A;  2PLL A;  3LHL A;  5BWZ A;  4DZ4 A;  5EFB D;  1P8N A;  3GN0 A;  5EEI A;  4LY1 A;  5EFJ D;  4A69 A;  5G0X A;  4IU5 A;  1XFK A;  1P8Q A;  1T5G A;  1T67 A;  4MYL A;  3ZNS A;  2ZAV A;  3EZT A;  1P8R A;  1TBJ A;  1HQ5 A;  1TBL A;  2CEV A;  3F0R A;  5IWG A;  4BZ5 A;  5EEM A;  1WVA A;  2VQM A;  3GMZ A;  4ITY A;  1W22 A;  1TBH A;  5EEK A;  3DJ8 A;  4BZ6 A;  3Q9C A;  3TH7 A;  1WOH A;  5EF8 A;  5G11 A;  1C3S A;  4CEV A;  3SJT A;  4QA0 A;  2VQW G;  5THU A;  1T4R A;  4HWW A;  1GQ7 A;  1PQ3 A;  1GQ6 A;  5A2S A;  3MZ7 A;  1P8P A;  4QA3 A;  3SL1 A;  5RLA A;  2PHA A;  1ZPE A;  3MZ3 A;  2EF4 A;  3Q9B A;  3MMR A;  1C3R A;  5IX0 A;  4Q3U A;  2AEB A;  3MAX A;  1ZZ0 A;  3F06 A;  4Q3T A;  4CQF A;  3SKK A;  4RN2 A;  2A0M A;  4MYK A;  4FCI A;  3MJL A;  2V5X A;  4ZUM A;  1P8S A;  2EF5 A;  5G13 A;  4IU4 A;  3THH A;  4LXZ A;  3THE A;  3KV2 A;  4Q3V A;  5CEV A;  1VKG A;  5D1C A;  4RHQ A;  5G1A A;  4IXU A;  5G10 A;  3MZ6 A;  4HZE A;  4IE3 A;  4Q3Q A;  3PZL A;  5DC8 A;  4GSZ A;  5THS A;  4ZUQ A;  3E9B A;  3E8Z A;  3E6V A;  3TF3 A;  4MYN A;  4GWD A;  4CBY A;  5G0Y A;  4QA1 A;  1T5F A;  4RHK A;  4RN0 A;  1T69 A;  1T4T A;  2RLA A;  4IE2 A;  3MEN A;  5EF7 A;  3RQD A;  2VQV A;  4QA7 A;  4IU1 A;  4GWC A;  2VCG A;  5EEF A;  5EEN A;  3M1R A;  1HQF A;  3EW8 A;  4Q42 A;  5G3W A;  4Q41 A;  1WOI A;  3E6K A;  4QA4 A;  3C0Z A;  5EFG A;  5FUE A;  4IE1 A;  5G0H A;  2EIV A;  5G12 A;  3SL0 A;  5HJ9 A;  5THV A;  5ICN B;  2VQJ A;  4Q40 A;  5G1C A;  3RLA A;  1WVB A;  4Q3P A;  4BZ7 A;  3EZP A;  5DC7 A;  3F07 A;  3EWF A;  4IU0 A;  3MZ4 A;  4FCK A;  5LI3 A;  5G17 A;  3NIO A;  4GSV A;  4Q3R A;  4QA2 A;  3ZNR A;  5JI5 A;  4ZUR A;  5HJA A;  1T4P A;  3MFV A;  5DC6 A;  3E8Q A;  5G0G A;  2V5W A;  1ZZ1 A;  4BZ9 A;  1CEV A;  4RHM A;  4RHJ A;  1HQX A;  5EFH A;  5EFK B;  3NIP A;  3NIQ A;  1TA1 A;  4RHI A;  5FCW A;  5D1B A;  5THT A;  1WOG A;  4MYF A;  4GSM A;  2GH6 A;  3C10 A;  3MFW A;  1HQG A;  5G0J A;  1ZPG A;  1RLA A;  4Q3R C;  5G1B A;  1T4S A;  3C0Y A;  5G0I A;  1T64 A;  2VQO A;  4ZUO A;  3SFF A;  3Q9F A;  4MXR A;  4RLA A;  2PHO A;  4ZUP A;  3LP4 A;  4BZ8 A;  1ZZ3 A;  4I06 A;  4ZUN A;  4HXQ A;  4BKX B;  4CBT A;  3SFH A;  5DC5 A;  3F80 A;  3LP7 A;  4QA5 A;  5EFN A;  4G3H A;  2VQQ A;  5D1D A;  1P8M A;  4Q3S A;  1D3V A;  4IXV A;  4RHL A;  1HQH A;  3Q9E A;  1C3P A;  3CEV A;  4QA6 A;  3THJ A;  1R1O A; 
#chains in the Genus database with same CATH homology
 1P8O A;  2PLL A;  3LHL A;  4DZ4 A;  1P8N A;  3GN0 A;  4IU5 A;  1XFK A;  1P8Q A;  1T5G A;  4MYL A;  2ZAV A;  1P8R A;  1TBJ A;  1HQ5 A;  1TBL A;  2CEV A;  1WVA A;  3GMZ A;  4ITY A;  1TBH A;  3DJ8 A;  3TH7 A;  1WOH A;  4CEV A;  3SJT A;  1T4R A;  4HWW A;  1GQ7 A;  1PQ3 A;  1P8P A;  3SL1 A;  5RLA A;  2PHA A;  1ZPE A;  2EF4 A;  3MMR A;  4Q3U A;  2AEB A;  4Q3T A;  3SKK A;  2A0M A;  4MYK A;  4FCI A;  3MJL A;  3THH A;  1P8S A;  2EF5 A;  4IU4 A;  3THE A;  3KV2 A;  4Q3V A;  5CEV A;  4RHQ A;  4IXU A;  4HZE A;  4IE3 A;  4Q3Q A;  3PZL A;  4GSZ A;  3E9B A;  3E8Z A;  3E6V A;  3TF3 A;  4MYN A;  4GWD A;  4RHK A;  1T5F A;  2RLA A;  1T4T A;  4IE2 A;  4IU1 A;  4GWC A;  3M1R A;  1HQF A;  4Q42 A;  4Q41 A;  1WOI A;  3E6K A;  4IE1 A;  2EIV A;  3SL0 A;  5HJ9 A;  4Q40 A;  3RLA A;  1WVB A;  4Q3P A;  4IU0 A;  4FCK A;  3NIO A;  4GSV A;  4Q3R A;  5HJA A;  1T4P A;  3MFV A;  3E8Q A;  1CEV A;  4RHM A;  4RHJ A;  1HQX A;  3NIP A;  3NIQ A;  1TA1 A;  4RHI A;  1WOG A;  4MYF A;  4GSM A;  3MFW A;  1HQG A;  1ZPG A;  1RLA A;  4Q3R C;  1T4S A;  4MXR A;  4RLA A;  2PHO A;  3LP4 A;  4I06 A;  4HXQ A;  3F80 A;  3LP7 A;  4G3H A;  1P8M A;  4Q3S A;  1D3V A;  4IXV A;  4RHL A;  1HQH A;  1GQ6 A;  3CEV A;  3THJ A;  1R1O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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