4IXUA

Crystal structure of human arginase-2 complexed with inhibitor 11d: {(5r)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-)
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
306
structure length
306
Chain Sequence
HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Arginase-2, mitochondrial
publication title Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
pubmed doi rcsb
source organism Homo sapiens
total genus 120
structure length 306
sequence length 306
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4ixuA00
4Q3SA 4CEVA 4IE3A 4FCIA 3NIPA 4RHJA 1TBLA 3GN0A 4IXUA 4MYKA 4Q3RC 4Q3PA 3LP7A 4Q3VA 3E8QA 3SL0A 1CEVA 1T5GA 3E6KA 3THJA 1T4PA 2PLLA 1HQXA 2EF4A 3MMRA 4MYFA 4IU1A 2PHOA 4RHMA 1T4SA 1D3VA 4Q3QA 3E6VA 3CEVA 3NIQA 1P8SA 1TBHA 4IU0A 1P8QA 1RLAA 1HQFA 1R1OA 4IE1A 2EIVA 1T5FA 1GQ7A 4MYNA 4GWCA 1ZPGA 2A0MA 2ZAVA 4RHQA 4HZEA 3TH7A 4HWWA 3TF3A 3NIOA 4I06A 1HQGA 3MFVA 1TA1A 2EF5A 3THEA 4MXRA 1PQ3A 4ITYA 3RLAA 4IXVA 1WOHA 4GWDA 4RHKA 4Q3UA 5HJAA 4G3HA 3MFWA 1ZPEA 1P8OA 4Q40A 4Q42A 1T4RA 3E9BA 1WOIA 4RLAA 1P8PA 3M1RA 3SL1A 4GSZA 1P8NA 1WVAA 4IU5A 1GQ6A 5RLAA 3KV2A 4RHIA 1WOGA 4IU4A 2CEVA 1P8RA 5HJ9A 2PHAA 4Q3TA 2AEBA 1XFKA 1HQHA 4GSVA 1P8MA 4IE2A 4MYLA 4FCKA 3DJ8A 4Q3RA 2RLAA 5CEVA 3MJLA 1WVBA 4HXQA 3PZLA 1HQ5A 3E8ZA 3LHLA 4Q41A 3F80A 3GMZA 1TBJA 4DZ4A 4GSMA 3SJTA 4RHLA 3LP4A 1T4TA 3SKKA 3THHA
chains in the Genus database with same CATH superfamily
3EZPA 4Q3SA 4CEVA 3Q9FA 3F07A 4FCIA 3NIPA 4IE3A 5THSA 5FCWA 4RHJA 1TBLA 3GN0A 3MZ7A 4IXUA 4MYKA 4Q3RC 4Q3PA 5G0IA 3SFHA 3MAXA 5EEKA 3LP7A 4Q3VA 3E8QA 3SL0A 5G10A 4BZ7A 1CEVA 4CBYA 4RN1A 3ZNRA 5EFBD 1W22A 5G0HA 1T64A 1T5GA 3E6KA 3Q9EA 3THJA 4QA2A 1T4PA 5D1BA 4ZUQA 4ZUMA 3Q9CA 5G3WA 2PLLA 5G0XA 1HQXA 2EF4A 3MMRA 5EENA 4MYFA 4IU1A 2PHOA 5EF8A 5G1CA 5G0GA 4RHMA 4BZ9A 1T4SA 4BZ8A 1D3VA 4BKXB 4Q3QA 3E6VA 3CEVA 5G12A 2VQOA 1P8SA 3NIQA 4ZURA 1TBHA 3RQDA 4A69A 4IU0A 1P8QA 1RLAA 3MZ6A 1HQFA 2GH6A 1R1OA 4IE1A 5JI5A 1T69A 2EIVA 4BZ5A 5EEMA 5DC5A 4ZUPA 1T5FA 1GQ7A 5EEIA 5EFHA 5G11A 4MYNA 4GWCA 3Q9BA 2VQVA 3C0ZA 5FUEA 1ZPGA 2A0MA 5IWGA 2ZAVA 4RHQA 4HZEA 1C3RA 1ZZ3A 3TH7A 1C3PA 5D1CA 4HWWA 3TF3A 3NIOA 4I06A 1HQGA 3MFVA 1TA1A 2EF5A 4QA5A 3THEA 4MXRA 1PQ3A 4ITYA 3RLAA 4IXVA 4ZUNA 1WOHA 3ZNSA 5A2SA 3MZ4A 1ZZ1A 2VCGA 5EF7A 3EWFA 4GWDA 3C10A 2VQJA 4RN2A 4RHKA 4Q3UA 5DC8A 5BWZA 4G3HA 3MFWA 5HJAA 1ZPEA 1P8OA 4Q40A 1T67A 3F0RA 5EFGA 4Q42A 1T4RA 2V5XA 1WOIA 3E9BA 1ZZ0A 4RLAA 5DC6A 1P8PA 3M1RA 5EFJD 3SL1A 4GSZA 4CBTA 1P8NA 1VKGA 1WVAA 2V5WA 4IU5A 1GQ6A 4LXZA 5RLAA 5EEFA 5LI3A 5G17A 3KV2A 4RHIA 5G0YA 5THVA 1WOGA 4IU4A 2CEVA 1P8RA 5HJ9A 5G0JA 5THUA 4QA3A 2PHAA 3EW8A 4Q3TA 2AEBA 1XFKA 1HQHA 4GSVA 5THTA 3MENA 4BZ6A 2VQMA 4QA0A 4QA1A 4QA4A 1P8MA 2VQWG 4IE2A 4MYLA 5EFKB 4FCKA 3DJ8A 5ICNB 4Q3RA 2RLAA 5CEVA 3MJLA 1WVBA 5G1AA 4HXQA 4CQFA 3PZLA 1HQ5A 3F06A 4QA7A 3E8ZA 3LHLA 1C3SA 4Q41A 2VQQA 4ZUOA 4QA6A 5DC7A 4RN0A 5G13A 3F80A 5G1BA 5D1DA 3GMZA 1TBJA 4DZ4A 3C0YA 3EZTA 3MZ3A 5EFNA 4GSMA 3SJTA 4RHLA 3LP4A 4LY1A 1T4TA 3SKKA 5IX0A 3THHA 3SFFA
chains in the Genus database with same CATH topology
4Q3SA 4CEVA 4IE3A 4FCIA 3NIPA 4RHJA 1TBLA 3GN0A 4IXUA 4MYKA 4Q3RC 4Q3PA 3LP7A 4Q3VA 3E8QA 3SL0A 1CEVA 1T5GA 3E6KA 3THJA 1T4PA 2PLLA 1HQXA 2EF4A 3MMRA 4MYFA 4IU1A 2PHOA 4RHMA 1T4SA 1D3VA 4Q3QA 3E6VA 3CEVA 3NIQA 1P8SA 1TBHA 4IU0A 1P8QA 1RLAA 1HQFA 1R1OA 4IE1A 2EIVA 1T5FA 1GQ7A 4MYNA 4GWCA 1ZPGA 2A0MA 2ZAVA 4RHQA 4HZEA 3TH7A 4HWWA 3TF3A 3NIOA 4I06A 1HQGA 3MFVA 1TA1A 2EF5A 3THEA 4MXRA 1PQ3A 4ITYA 3RLAA 4IXVA 1WOHA 4GWDA 4RHKA 4Q3UA 5HJAA 4G3HA 3MFWA 1ZPEA 1P8OA 4Q40A 4Q42A 1T4RA 3E9BA 1WOIA 4RLAA 1P8PA 3M1RA 3SL1A 4GSZA 1P8NA 1WVAA 4IU5A 1GQ6A 5RLAA 3KV2A 4RHIA 1WOGA 4IU4A 2CEVA 1P8RA 5HJ9A 2PHAA 4Q3TA 2AEBA 1XFKA 1HQHA 4GSVA 1P8MA 4IE2A 4MYLA 4FCKA 3DJ8A 4Q3RA 2RLAA 5CEVA 3MJLA 1WVBA 4HXQA 3PZLA 1HQ5A 3E8ZA 3LHLA 4Q41A 3F80A 3GMZA 1TBJA 4DZ4A 4GSMA 3SJTA 4RHLA 3LP4A 1T4TA 3SKKA 3THHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Q3S A;  4CEV A;  4IE3 A;  4FCI A;  3NIP A;  4RHJ A;  1TBL A;  3GN0 A;  4IXU A;  4MYK A;  4Q3R C;  4Q3P A;  3LP7 A;  4Q3V A;  3E8Q A;  3SL0 A;  1CEV A;  1T5G A;  3E6K A;  3THJ A;  1T4P A;  2PLL A;  1HQX A;  2EF4 A;  3MMR A;  4MYF A;  4IU1 A;  2PHO A;  4RHM A;  1T4S A;  1D3V A;  4Q3Q A;  3E6V A;  3CEV A;  3NIQ A;  1P8S A;  1TBH A;  4IU0 A;  1P8Q A;  1RLA A;  1HQF A;  1R1O A;  4IE1 A;  2EIV A;  1T5F A;  1GQ7 A;  4MYN A;  4GWC A;  1ZPG A;  2A0M A;  2ZAV A;  4RHQ A;  4HZE A;  3TH7 A;  4HWW A;  3TF3 A;  3NIO A;  4I06 A;  1HQG A;  3MFV A;  1TA1 A;  2EF5 A;  3THE A;  4MXR A;  1PQ3 A;  4ITY A;  3RLA A;  4IXV A;  1WOH A;  4GWD A;  4RHK A;  4Q3U A;  5HJA A;  4G3H A;  3MFW A;  1ZPE A;  1P8O A;  4Q40 A;  4Q42 A;  1T4R A;  3E9B A;  1WOI A;  4RLA A;  1P8P A;  3M1R A;  3SL1 A;  4GSZ A;  1P8N A;  1WVA A;  4IU5 A;  1GQ6 A;  5RLA A;  3KV2 A;  4RHI A;  1WOG A;  4IU4 A;  2CEV A;  1P8R A;  5HJ9 A;  2PHA A;  4Q3T A;  2AEB A;  1XFK A;  1HQH A;  4GSV A;  1P8M A;  4IE2 A;  4MYL A;  4FCK A;  3DJ8 A;  4Q3R A;  2RLA A;  5CEV A;  3MJL A;  1WVB A;  4HXQ A;  3PZL A;  1HQ5 A;  3E8Z A;  3LHL A;  4Q41 A;  3F80 A;  3GMZ A;  1TBJ A;  4DZ4 A;  4GSM A;  3SJT A;  4RHL A;  3LP4 A;  1T4T A;  3SKK A;  3THH A; 
#chains in the Genus database with same CATH topology
 3EZP A;  4Q3S A;  4CEV A;  3Q9F A;  3F07 A;  4FCI A;  3NIP A;  4IE3 A;  5THS A;  5FCW A;  4RHJ A;  1TBL A;  3GN0 A;  3MZ7 A;  4IXU A;  4MYK A;  4Q3R C;  4Q3P A;  5G0I A;  3SFH A;  3MAX A;  5EEK A;  3LP7 A;  4Q3V A;  3E8Q A;  3SL0 A;  5G10 A;  4BZ7 A;  1CEV A;  4CBY A;  4RN1 A;  3ZNR A;  5EFB D;  1W22 A;  5G0H A;  1T64 A;  1T5G A;  3E6K A;  3Q9E A;  3THJ A;  4QA2 A;  1T4P A;  5D1B A;  4ZUQ A;  4ZUM A;  3Q9C A;  5G3W A;  2PLL A;  5G0X A;  1HQX A;  2EF4 A;  3MMR A;  5EEN A;  4MYF A;  4IU1 A;  2PHO A;  5EF8 A;  5G1C A;  5G0G A;  4RHM A;  4BZ9 A;  1T4S A;  4BZ8 A;  1D3V A;  4BKX B;  4Q3Q A;  3E6V A;  3CEV A;  5G12 A;  2VQO A;  1P8S A;  3NIQ A;  4ZUR A;  1TBH A;  3RQD A;  4A69 A;  4IU0 A;  1P8Q A;  1RLA A;  3MZ6 A;  1HQF A;  2GH6 A;  1R1O A;  4IE1 A;  5JI5 A;  1T69 A;  2EIV A;  4BZ5 A;  5EEM A;  5DC5 A;  4ZUP A;  1T5F A;  1GQ7 A;  5EEI A;  5EFH A;  5G11 A;  4MYN A;  4GWC A;  3Q9B A;  2VQV A;  3C0Z A;  5FUE A;  1ZPG A;  2A0M A;  5IWG A;  2ZAV A;  4RHQ A;  4HZE A;  1C3R A;  1ZZ3 A;  3TH7 A;  1C3P A;  5D1C A;  4HWW A;  3TF3 A;  3NIO A;  4I06 A;  1HQG A;  3MFV A;  1TA1 A;  2EF5 A;  4QA5 A;  3THE A;  4MXR A;  1PQ3 A;  4ITY A;  3RLA A;  4IXV A;  4ZUN A;  1WOH A;  3ZNS A;  5A2S A;  3MZ4 A;  1ZZ1 A;  2VCG A;  5EF7 A;  3EWF A;  4GWD A;  3C10 A;  2VQJ A;  4RN2 A;  4RHK A;  4Q3U A;  5DC8 A;  5BWZ A;  4G3H A;  3MFW A;  5HJA A;  1ZPE A;  1P8O A;  4Q40 A;  1T67 A;  3F0R A;  5EFG A;  4Q42 A;  1T4R A;  2V5X A;  1WOI A;  3E9B A;  1ZZ0 A;  4RLA A;  5DC6 A;  1P8P A;  3M1R A;  5EFJ D;  3SL1 A;  4GSZ A;  4CBT A;  1P8N A;  1VKG A;  1WVA A;  2V5W A;  4IU5 A;  1GQ6 A;  4LXZ A;  5RLA A;  5EEF A;  5LI3 A;  5G17 A;  3KV2 A;  4RHI A;  5G0Y A;  5THV A;  1WOG A;  4IU4 A;  2CEV A;  1P8R A;  5HJ9 A;  5G0J A;  5THU A;  4QA3 A;  2PHA A;  3EW8 A;  4Q3T A;  2AEB A;  1XFK A;  1HQH A;  4GSV A;  5THT A;  3MEN A;  4BZ6 A;  2VQM A;  4QA0 A;  4QA1 A;  4QA4 A;  1P8M A;  2VQW G;  4IE2 A;  4MYL A;  5EFK B;  4FCK A;  3DJ8 A;  5ICN B;  4Q3R A;  2RLA A;  5CEV A;  3MJL A;  1WVB A;  5G1A A;  4HXQ A;  4CQF A;  3PZL A;  1HQ5 A;  3F06 A;  4QA7 A;  3E8Z A;  3LHL A;  1C3S A;  4Q41 A;  2VQQ A;  4ZUO A;  4QA6 A;  5DC7 A;  4RN0 A;  5G13 A;  3F80 A;  5G1B A;  5D1D A;  3GMZ A;  1TBJ A;  4DZ4 A;  3C0Y A;  3EZT A;  3MZ3 A;  5EFN A;  4GSM A;  3SJT A;  4RHL A;  3LP4 A;  4LY1 A;  1T4T A;  3SKK A;  5IX0 A;  3THH A;  3SFF A; 
#chains in the Genus database with same CATH homology
 4Q3S A;  4CEV A;  4IE3 A;  4FCI A;  3NIP A;  4RHJ A;  1TBL A;  3GN0 A;  4IXU A;  4MYK A;  4Q3R C;  4Q3P A;  3LP7 A;  4Q3V A;  3E8Q A;  3SL0 A;  1CEV A;  1T5G A;  3E6K A;  3THJ A;  1T4P A;  2PLL A;  1HQX A;  2EF4 A;  3MMR A;  4MYF A;  4IU1 A;  2PHO A;  4RHM A;  1T4S A;  1D3V A;  4Q3Q A;  3E6V A;  3CEV A;  3NIQ A;  1P8S A;  1TBH A;  4IU0 A;  1P8Q A;  1RLA A;  1HQF A;  1R1O A;  4IE1 A;  2EIV A;  1T5F A;  1GQ7 A;  4MYN A;  4GWC A;  1ZPG A;  2A0M A;  2ZAV A;  4RHQ A;  4HZE A;  3TH7 A;  4HWW A;  3TF3 A;  3NIO A;  4I06 A;  1HQG A;  3MFV A;  1TA1 A;  2EF5 A;  3THE A;  4MXR A;  1PQ3 A;  4ITY A;  3RLA A;  4IXV A;  1WOH A;  4GWD A;  4RHK A;  4Q3U A;  5HJA A;  4G3H A;  3MFW A;  1ZPE A;  1P8O A;  4Q40 A;  4Q42 A;  1T4R A;  3E9B A;  1WOI A;  4RLA A;  1P8P A;  3M1R A;  3SL1 A;  4GSZ A;  1P8N A;  1WVA A;  4IU5 A;  1GQ6 A;  5RLA A;  3KV2 A;  4RHI A;  1WOG A;  4IU4 A;  2CEV A;  1P8R A;  5HJ9 A;  2PHA A;  4Q3T A;  2AEB A;  1XFK A;  1HQH A;  4GSV A;  1P8M A;  4IE2 A;  4MYL A;  4FCK A;  3DJ8 A;  4Q3R A;  2RLA A;  5CEV A;  3MJL A;  1WVB A;  4HXQ A;  3PZL A;  1HQ5 A;  3E8Z A;  3LHL A;  4Q41 A;  3F80 A;  3GMZ A;  1TBJ A;  4DZ4 A;  4GSM A;  3SJT A;  4RHL A;  3LP4 A;  1T4T A;  3SKK A;  3THH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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