4IXVA

Crystal structure of human arginase-2 complexed with inhibitor 2d: {(5r)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
306
structure length
306
Chain Sequence
HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Arginase-2, mitochondrial
publication title Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
pubmed doi rcsb
source organism Homo sapiens
total genus 116
structure length 306
sequence length 306
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4ixvA00
3E8QA 2PHOA 2A0MA 1WOHA 4ITYA 3THHA 1T4TA 4FCKA 1HQHA 4Q3PA 2EIVA 3M1RA 4IXUA 3NIOA 4Q42A 3LP7A 1TBHA 4Q3RA 4Q3QA 1WOGA 3E9BA 1ZPEA 3MFWA 4RHKA 3E8ZA 1GQ7A 1PQ3A 3NIPA 4Q3TA 3SKKA 1T4RA 4DZ4A 3F80A 1TA1A 2CEVA 1ZPGA 4GSMA 3MMRA 3KV2A 4RHMA 1D3VA 4MYLA 3DJ8A 4Q41A 1GQ6A 4Q40A 2PHAA 4MYFA 1P8PA 3THJA 4MYKA 1TBLA 3TF3A 5HJ9A 3MJLA 4HXQA 3MFVA 4IU4A 1T5FA 2PLLA 3E6KA 3RLAA 1HQGA 1T5GA 3GMZA 3PZLA 1RLAA 4FCIA 4IU0A 4IE3A 4HWWA 1WOIA 1R1OA 2RLAA 3E6VA 1TBJA 4GWDA 4HZEA 3LP4A 4GWCA 3SJTA 1WVAA 4IU5A 4Q3RC 4RHJA 4MXRA 4MYNA 1P8MA 4IU1A 4IE1A 5CEVA 5HJAA 4Q3VA 1WVBA 4Q3SA 3LHLA 4RHIA 4GSZA 2EF5A 1P8SA 1P8OA 3SL0A 1HQ5A 1HQFA 2EF4A 1CEVA 3NIQA 1T4PA 4I06A 1P8QA 2ZAVA 4Q3UA 1HQXA 1T4SA 4IE2A 4IXVA 1XFKA 3CEVA 3TH7A 5RLAA 3GN0A 3THEA 4GSVA 4CEVA 4RHQA 3SL1A 4RHLA 2AEBA 1P8RA 4RLAA 1P8NA 4G3HA
chains in the Genus database with same CATH superfamily
3E8QA 2PHOA 2A0MA 1WOHA 3Q9BA 4ITYA 5THVA 1T4TA 4FCKA 1HQHA 1ZZ0A 2EIVA 4Q3PA 3M1RA 5G3WA 3THHA 4IXUA 3NIOA 4Q42A 4QA4A 3LP7A 3Q9EA 5FUEA 1T69A 1TBHA 3MAXA 4Q3QA 4Q3RA 1WOGA 5THSA 3E9BA 4CQFA 1ZPEA 2V5WA 1W22A 3MFWA 4RHKA 5JI5A 3E8ZA 5D1BA 1GQ7A 5EFKB 5FCWA 4A69A 4ZUOA 4QA0A 1PQ3A 3NIPA 4QA5A 4BZ9A 2VQOA 4Q3TA 4RN2A 3SKKA 1T4RA 4BZ5A 2VQQA 5LI3A 4DZ4A 3F80A 5G0YA 1TA1A 1ZZ1A 2CEVA 4QA2A 2VCGA 1ZPGA 2GH6A 2VQJA 3EZPA 4GSMA 3MMRA 3KV2A 2V5XA 4RHMA 1D3VA 5G17A 4QA3A 4ZUMA 4MYLA 3DJ8A 5G0XA 4Q41A 1GQ6A 4Q40A 2PHAA 4MYFA 1P8PA 3MZ6A 4RN0A 3THJA 4MYKA 5EFHA 1TBLA 3TF3A 3MZ3A 5HJ9A 3C0YA 3MJLA 5D1DA 4HXQA 3MFVA 1C3PA 4IU4A 5G11A 1T5FA 2PLLA 3E6KA 5EF7A 3SFHA 5G1CA 3RQDA 4CBYA 5EEKA 3MZ4A 3RLAA 3Q9FA 4ZUQA 1HQGA 1T5GA 3GMZA 3PZLA 1RLAA 4FCIA 4IU0A 5BWZA 4IE3A 4HWWA 5ICNB 4LY1A 1WOIA 5EFNA 1R1OA 2RLAA 3Q9CA 3F06A 3ZNRA 3E6VA 3MENA 1TBJA 4GWDA 4HZEA 5G0IA 5EFGA 3LP4A 1C3SA 4QA1A 4GWCA 3SJTA 5IWGA 5G0GA 4ZUPA 4BZ7A 4BZ8A 1WVAA 1T64A 1T67A 4IU5A 4Q3RC 4RHJA 1ZZ3A 4MXRA 5G0HA 3MZ7A 4ZURA 1C3RA 5G10A 4MYNA 1P8MA 5D1CA 4LXZA 4IU1A 5EF8A 5EFBD 5THUA 3ZNSA 4IE1A 5DC5A 3EZTA 4QA6A 5CEVA 3EWFA 5HJAA 3SFFA 4Q3VA 5A2SA 1WVBA 4Q3SA 3LHLA 4QA7A 2VQMA 5EFJD 4RHIA 5G13A 4GSZA 2EF5A 1P8SA 1P8OA 4ZUNA 3SL0A 1HQ5A 1HQFA 3F07A 2EF4A 1CEVA 5EEIA 3NIQA 1T4PA 4I06A 1P8QA 2ZAVA 3F0RA 5IX0A 4Q3UA 1VKGA 1HQXA 1T4SA 3C10A 4IE2A 4IXVA 5G1BA 5EEFA 1XFKA 5G1AA 5G12A 5G0JA 3CEVA 3TH7A 5RLAA 5EEMA 3GN0A 3THEA 4GSVA 4RN1A 4BZ6A 2VQWG 3EW8A 4CEVA 4RHQA 5DC8A 3SL1A 5THTA 4RHLA 2AEBA 5EENA 4CBTA 1P8RA 2VQVA 3C0ZA 5DC6A 4RLAA 4BKXB 1P8NA 4G3HA 5DC7A
chains in the Genus database with same CATH topology
3E8QA 2PHOA 2A0MA 1WOHA 4ITYA 3THHA 1T4TA 4FCKA 1HQHA 4Q3PA 2EIVA 3M1RA 4IXUA 3NIOA 4Q42A 3LP7A 1TBHA 4Q3RA 4Q3QA 1WOGA 3E9BA 1ZPEA 3MFWA 4RHKA 3E8ZA 1GQ7A 1PQ3A 3NIPA 4Q3TA 3SKKA 1T4RA 4DZ4A 3F80A 1TA1A 2CEVA 1ZPGA 4GSMA 3MMRA 3KV2A 4RHMA 1D3VA 4MYLA 3DJ8A 4Q41A 1GQ6A 4Q40A 2PHAA 4MYFA 1P8PA 3THJA 4MYKA 1TBLA 3TF3A 5HJ9A 3MJLA 4HXQA 3MFVA 4IU4A 1T5FA 2PLLA 3E6KA 3RLAA 1HQGA 1T5GA 3GMZA 3PZLA 1RLAA 4FCIA 4IU0A 4IE3A 4HWWA 1WOIA 1R1OA 2RLAA 3E6VA 1TBJA 4GWDA 4HZEA 3LP4A 4GWCA 3SJTA 1WVAA 4IU5A 4Q3RC 4RHJA 4MXRA 4MYNA 1P8MA 4IU1A 4IE1A 5CEVA 5HJAA 4Q3VA 1WVBA 4Q3SA 3LHLA 4RHIA 4GSZA 2EF5A 1P8SA 1P8OA 3SL0A 1HQ5A 1HQFA 2EF4A 1CEVA 3NIQA 1T4PA 4I06A 1P8QA 2ZAVA 4Q3UA 1HQXA 1T4SA 4IE2A 4IXVA 1XFKA 3CEVA 3TH7A 5RLAA 3GN0A 3THEA 4GSVA 4CEVA 4RHQA 3SL1A 4RHLA 2AEBA 1P8RA 4RLAA 1P8NA 4G3HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E8Q A;  2PHO A;  2A0M A;  1WOH A;  4ITY A;  3THH A;  1T4T A;  4FCK A;  1HQH A;  4Q3P A;  2EIV A;  3M1R A;  4IXU A;  3NIO A;  4Q42 A;  3LP7 A;  1TBH A;  4Q3R A;  4Q3Q A;  1WOG A;  3E9B A;  1ZPE A;  3MFW A;  4RHK A;  3E8Z A;  1GQ7 A;  1PQ3 A;  3NIP A;  4Q3T A;  3SKK A;  1T4R A;  4DZ4 A;  3F80 A;  1TA1 A;  2CEV A;  1ZPG A;  4GSM A;  3MMR A;  3KV2 A;  4RHM A;  1D3V A;  4MYL A;  3DJ8 A;  4Q41 A;  1GQ6 A;  4Q40 A;  2PHA A;  4MYF A;  1P8P A;  3THJ A;  4MYK A;  1TBL A;  3TF3 A;  5HJ9 A;  3MJL A;  4HXQ A;  3MFV A;  4IU4 A;  1T5F A;  2PLL A;  3E6K A;  3RLA A;  1HQG A;  1T5G A;  3GMZ A;  3PZL A;  1RLA A;  4FCI A;  4IU0 A;  4IE3 A;  4HWW A;  1WOI A;  1R1O A;  2RLA A;  3E6V A;  1TBJ A;  4GWD A;  4HZE A;  3LP4 A;  4GWC A;  3SJT A;  1WVA A;  4IU5 A;  4Q3R C;  4RHJ A;  4MXR A;  4MYN A;  1P8M A;  4IU1 A;  4IE1 A;  5CEV A;  5HJA A;  4Q3V A;  1WVB A;  4Q3S A;  3LHL A;  4RHI A;  4GSZ A;  2EF5 A;  1P8S A;  1P8O A;  3SL0 A;  1HQ5 A;  1HQF A;  2EF4 A;  1CEV A;  3NIQ A;  1T4P A;  4I06 A;  1P8Q A;  2ZAV A;  4Q3U A;  1HQX A;  1T4S A;  4IE2 A;  4IXV A;  1XFK A;  3CEV A;  3TH7 A;  5RLA A;  3GN0 A;  3THE A;  4GSV A;  4CEV A;  4RHQ A;  3SL1 A;  4RHL A;  2AEB A;  1P8R A;  4RLA A;  1P8N A;  4G3H A; 
#chains in the Genus database with same CATH topology
 3E8Q A;  2PHO A;  2A0M A;  1WOH A;  3Q9B A;  4ITY A;  5THV A;  1T4T A;  4FCK A;  1HQH A;  1ZZ0 A;  2EIV A;  4Q3P A;  3M1R A;  5G3W A;  3THH A;  4IXU A;  3NIO A;  4Q42 A;  4QA4 A;  3LP7 A;  3Q9E A;  5FUE A;  1T69 A;  1TBH A;  3MAX A;  4Q3Q A;  4Q3R A;  1WOG A;  5THS A;  3E9B A;  4CQF A;  1ZPE A;  2V5W A;  1W22 A;  3MFW A;  4RHK A;  5JI5 A;  3E8Z A;  5D1B A;  1GQ7 A;  5EFK B;  5FCW A;  4A69 A;  4ZUO A;  4QA0 A;  1PQ3 A;  3NIP A;  4QA5 A;  4BZ9 A;  2VQO A;  4Q3T A;  4RN2 A;  3SKK A;  1T4R A;  4BZ5 A;  2VQQ A;  5LI3 A;  4DZ4 A;  3F80 A;  5G0Y A;  1TA1 A;  1ZZ1 A;  2CEV A;  4QA2 A;  2VCG A;  1ZPG A;  2GH6 A;  2VQJ A;  3EZP A;  4GSM A;  3MMR A;  3KV2 A;  2V5X A;  4RHM A;  1D3V A;  5G17 A;  4QA3 A;  4ZUM A;  4MYL A;  3DJ8 A;  5G0X A;  4Q41 A;  1GQ6 A;  4Q40 A;  2PHA A;  4MYF A;  1P8P A;  3MZ6 A;  4RN0 A;  3THJ A;  4MYK A;  5EFH A;  1TBL A;  3TF3 A;  3MZ3 A;  5HJ9 A;  3C0Y A;  3MJL A;  5D1D A;  4HXQ A;  3MFV A;  1C3P A;  4IU4 A;  5G11 A;  1T5F A;  2PLL A;  3E6K A;  5EF7 A;  3SFH A;  5G1C A;  3RQD A;  4CBY A;  5EEK A;  3MZ4 A;  3RLA A;  3Q9F A;  4ZUQ A;  1HQG A;  1T5G A;  3GMZ A;  3PZL A;  1RLA A;  4FCI A;  4IU0 A;  5BWZ A;  4IE3 A;  4HWW A;  5ICN B;  4LY1 A;  1WOI A;  5EFN A;  1R1O A;  2RLA A;  3Q9C A;  3F06 A;  3ZNR A;  3E6V A;  3MEN A;  1TBJ A;  4GWD A;  4HZE A;  5G0I A;  5EFG A;  3LP4 A;  1C3S A;  4QA1 A;  4GWC A;  3SJT A;  5IWG A;  5G0G A;  4ZUP A;  4BZ7 A;  4BZ8 A;  1WVA A;  1T64 A;  1T67 A;  4IU5 A;  4Q3R C;  4RHJ A;  1ZZ3 A;  4MXR A;  5G0H A;  3MZ7 A;  4ZUR A;  1C3R A;  5G10 A;  4MYN A;  1P8M A;  5D1C A;  4LXZ A;  4IU1 A;  5EF8 A;  5EFB D;  5THU A;  3ZNS A;  4IE1 A;  5DC5 A;  3EZT A;  4QA6 A;  5CEV A;  3EWF A;  5HJA A;  3SFF A;  4Q3V A;  5A2S A;  1WVB A;  4Q3S A;  3LHL A;  4QA7 A;  2VQM A;  5EFJ D;  4RHI A;  5G13 A;  4GSZ A;  2EF5 A;  1P8S A;  1P8O A;  4ZUN A;  3SL0 A;  1HQ5 A;  1HQF A;  3F07 A;  2EF4 A;  1CEV A;  5EEI A;  3NIQ A;  1T4P A;  4I06 A;  1P8Q A;  2ZAV A;  3F0R A;  5IX0 A;  4Q3U A;  1VKG A;  1HQX A;  1T4S A;  3C10 A;  4IE2 A;  4IXV A;  5G1B A;  5EEF A;  1XFK A;  5G1A A;  5G12 A;  5G0J A;  3CEV A;  3TH7 A;  5RLA A;  5EEM A;  3GN0 A;  3THE A;  4GSV A;  4RN1 A;  4BZ6 A;  2VQW G;  3EW8 A;  4CEV A;  4RHQ A;  5DC8 A;  3SL1 A;  5THT A;  4RHL A;  2AEB A;  5EEN A;  4CBT A;  1P8R A;  2VQV A;  3C0Z A;  5DC6 A;  4RLA A;  4BKX B;  1P8N A;  4G3H A;  5DC7 A; 
#chains in the Genus database with same CATH homology
 3E8Q A;  2PHO A;  2A0M A;  1WOH A;  4ITY A;  3THH A;  1T4T A;  4FCK A;  1HQH A;  4Q3P A;  2EIV A;  3M1R A;  4IXU A;  3NIO A;  4Q42 A;  3LP7 A;  1TBH A;  4Q3R A;  4Q3Q A;  1WOG A;  3E9B A;  1ZPE A;  3MFW A;  4RHK A;  3E8Z A;  1GQ7 A;  1PQ3 A;  3NIP A;  4Q3T A;  3SKK A;  1T4R A;  4DZ4 A;  3F80 A;  1TA1 A;  2CEV A;  1ZPG A;  4GSM A;  3MMR A;  3KV2 A;  4RHM A;  1D3V A;  4MYL A;  3DJ8 A;  4Q41 A;  1GQ6 A;  4Q40 A;  2PHA A;  4MYF A;  1P8P A;  3THJ A;  4MYK A;  1TBL A;  3TF3 A;  5HJ9 A;  3MJL A;  4HXQ A;  3MFV A;  4IU4 A;  1T5F A;  2PLL A;  3E6K A;  3RLA A;  1HQG A;  1T5G A;  3GMZ A;  3PZL A;  1RLA A;  4FCI A;  4IU0 A;  4IE3 A;  4HWW A;  1WOI A;  1R1O A;  2RLA A;  3E6V A;  1TBJ A;  4GWD A;  4HZE A;  3LP4 A;  4GWC A;  3SJT A;  1WVA A;  4IU5 A;  4Q3R C;  4RHJ A;  4MXR A;  4MYN A;  1P8M A;  4IU1 A;  4IE1 A;  5CEV A;  5HJA A;  4Q3V A;  1WVB A;  4Q3S A;  3LHL A;  4RHI A;  4GSZ A;  2EF5 A;  1P8S A;  1P8O A;  3SL0 A;  1HQ5 A;  1HQF A;  2EF4 A;  1CEV A;  3NIQ A;  1T4P A;  4I06 A;  1P8Q A;  2ZAV A;  4Q3U A;  1HQX A;  1T4S A;  4IE2 A;  4IXV A;  1XFK A;  3CEV A;  3TH7 A;  5RLA A;  3GN0 A;  3THE A;  4GSV A;  4CEV A;  4RHQ A;  3SL1 A;  4RHL A;  2AEB A;  1P8R A;  4RLA A;  1P8N A;  4G3H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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