4RLAA

Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDNSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords ARGINASE
publication title Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
pubmed doi rcsb
source organism Rattus norvegicus
total genus 108
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 1997-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4rlaA00
1T5FA 1P8SA 4ITYA 4Q3RC 3MFWA 3LP7A 2EIVA 1HQHA 1TBJA 4GSVA 4HWWA 1TBHA 4RHKA 4IU1A 3E9BA 2EF4A 4MYNA 4MYLA 4Q3PA 4RHIA 5HJ9A 1WOGA 1TA1A 1XFKA 4FCKA 1P8MA 3MMRA 1WOHA 4Q3UA 1HQGA 3MFVA 4MXRA 4I06A 1CEVA 1T4SA 1P8RA 3GMZA 3CEVA 1WVAA 4Q3RA 4IE3A 4GWDA 3GN0A 2A0MA 1P8QA 3SL0A 2CEVA 4IXUA 1P8OA 1T4TA 4Q3QA 4IE1A 3THJA 4Q3VA 4GSMA 3SL1A 4Q40A 2PHAA 3LHLA 4Q3SA 4CEVA 4RLAA 4MYKA 2ZAVA 1HQFA 4RHQA 3NIQA 3TH7A 2PLLA 1GQ6A 3E6VA 3LP4A 4IE2A 1ZPGA 2AEBA 3NIPA 3SJTA 3THHA 4MYFA 1P8PA 4GWCA 5RLAA 4Q3TA 3MJLA 4GSZA 4G3HA 3PZLA 1R1OA 1HQ5A 3THEA 2PHOA 3KV2A 4IU4A 3DJ8A 4Q41A 1RLAA 4IU5A 1ZPEA 3E8QA 1HQXA 4FCIA 1P8NA 3M1RA 4HXQA 1TBLA 4HZEA 4RHLA 3SKKA 1GQ7A 1WOIA 4RHMA 1D3VA 1T4RA 4DZ4A 1PQ3A 3E6KA 4IU0A 3E8ZA 3F80A 5HJAA 1T5GA 1T4PA 4RHJA 4IXVA 3RLAA 2EF5A 2RLAA 3NIOA 4Q42A 3TF3A 1WVBA 5CEVA
chains in the Genus database with same CATH superfamily
1T5FA 1P8SA 3EZPA 3SFHA 4ITYA 5G0JA 4Q3RC 5THUA 5G1BA 3MFWA 3LP7A 3MENA 4CBTA 2EIVA 3SFFA 1HQHA 1ZZ0A 5DC8A 5DC7A 1TBJA 4GSVA 4HWWA 1TBHA 4RHKA 2VQJA 4IU1A 5EFNA 3ZNRA 5JI5A 3E9BA 2EF4A 3EZTA 3C10A 4ZUNA 4LXZA 5EFGA 5D1CA 1C3RA 4MYNA 4MYLA 5G17A 4Q3PA 5G3WA 4RHIA 4ZURA 1WOGA 5HJ9A 1TA1A 4BKXB 5EENA 1VKGA 2VQVA 5G0IA 2VQOA 1XFKA 1ZZ3A 4FCKA 1P8MA 3MMRA 5G11A 5DC6A 1WOHA 4Q3UA 1HQGA 5G12A 3MFVA 4MXRA 4I06A 1CEVA 4A69A 2VQQA 1T4SA 1P8RA 4QA5A 2GH6A 3GMZA 5G0GA 5EFJD 5THTA 4BZ8A 3CEVA 1WVAA 5IX0A 4Q3RA 3MZ4A 4BZ7A 5DC5A 3C0ZA 5EF7A 3MZ7A 5EFHA 3Q9BA 4IE3A 5IWGA 4QA7A 5G0HA 2VQMA 3GN0A 2A0MA 3Q9CA 4GWDA 4LY1A 1P8QA 3SL0A 2CEVA 2VCGA 4IXUA 4QA4A 1P8OA 4RN1A 4CQFA 1T4TA 4Q3QA 4IE1A 3THJA 4Q3VA 5LI3A 4GSMA 3SL1A 4ZUPA 4Q40A 2PHAA 3LHLA 1W22A 4Q3SA 4BZ5A 4RLAA 4CEVA 4MYKA 2ZAVA 1HQFA 4RHQA 3NIQA 5G0XA 3TH7A 2PLLA 4ZUQA 5G10A 1GQ6A 3E6VA 3LP4A 4IE2A 5G1CA 5G13A 1ZPGA 2AEBA 3NIPA 3Q9FA 3RQDA 3SJTA 4RN0A 3THHA 4MYFA 1P8PA 3F0RA 4GWCA 5G0YA 5RLAA 3ZNSA 4Q3TA 4QA0A 3MJLA 4GSZA 5EF8A 5EFKB 4G3HA 3PZLA 1C3PA 1R1OA 1HQ5A 3THEA 2PHOA 2VQWG 3KV2A 4IU4A 4QA6A 3DJ8A 4ZUOA 4Q41A 1T69A 5G1AA 3EWFA 3MZ6A 1RLAA 4IU5A 1ZPEA 4BZ6A 5THSA 3E8QA 4RN2A 1HQXA 4FCIA 5EFBD 1P8NA 4QA1A 3M1RA 5A2SA 4HXQA 1TBLA 3F06A 5EEKA 4HZEA 4RHLA 1ZZ1A 1GQ7A 3SKKA 4ZUMA 1WOIA 3C0YA 4RHMA 3MZ3A 1D3VA 5BWZA 4CBYA 1T4RA 5FCWA 4QA2A 4DZ4A 1T67A 1PQ3A 3E6KA 4BZ9A 5EEFA 2V5WA 4IU0A 5EEIA 3E8ZA 3Q9EA 5EEMA 3F80A 5FUEA 5THVA 5HJAA 1T5GA 5ICNB 1T4PA 4QA3A 4RHJA 1C3SA 4IXVA 2V5XA 3EW8A 5D1BA 5D1DA 3RLAA 2EF5A 1T64A 2RLAA 3F07A 3MAXA 3NIOA 1WVBA 4Q42A 3TF3A 5CEVA
chains in the Genus database with same CATH topology
1T5FA 1P8SA 4ITYA 4Q3RC 3MFWA 3LP7A 2EIVA 1HQHA 1TBJA 4GSVA 4HWWA 1TBHA 4RHKA 4IU1A 3E9BA 2EF4A 4MYNA 4MYLA 4Q3PA 4RHIA 5HJ9A 1WOGA 1TA1A 1XFKA 4FCKA 1P8MA 3MMRA 1WOHA 4Q3UA 1HQGA 3MFVA 4MXRA 4I06A 1CEVA 1T4SA 1P8RA 3GMZA 3CEVA 1WVAA 4Q3RA 4IE3A 4GWDA 3GN0A 2A0MA 1P8QA 3SL0A 2CEVA 4IXUA 1P8OA 1T4TA 4Q3QA 4IE1A 3THJA 4Q3VA 4GSMA 3SL1A 4Q40A 2PHAA 3LHLA 4Q3SA 4CEVA 4RLAA 4MYKA 2ZAVA 1HQFA 4RHQA 3NIQA 3TH7A 2PLLA 1GQ6A 3E6VA 3LP4A 4IE2A 1ZPGA 2AEBA 3NIPA 3SJTA 3THHA 4MYFA 1P8PA 4GWCA 5RLAA 4Q3TA 3MJLA 4GSZA 4G3HA 3PZLA 1R1OA 1HQ5A 3THEA 2PHOA 3KV2A 4IU4A 3DJ8A 4Q41A 1RLAA 4IU5A 1ZPEA 3E8QA 1HQXA 4FCIA 1P8NA 3M1RA 4HXQA 1TBLA 4HZEA 4RHLA 3SKKA 1GQ7A 1WOIA 4RHMA 1D3VA 1T4RA 4DZ4A 1PQ3A 3E6KA 4IU0A 3E8ZA 3F80A 5HJAA 1T5GA 1T4PA 4RHJA 4IXVA 3RLAA 2EF5A 2RLAA 3NIOA 4Q42A 3TF3A 1WVBA 5CEVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T5F A;  1P8S A;  4ITY A;  4Q3R C;  3MFW A;  3LP7 A;  2EIV A;  1HQH A;  1TBJ A;  4GSV A;  4HWW A;  1TBH A;  4RHK A;  4IU1 A;  3E9B A;  2EF4 A;  4MYN A;  4MYL A;  4Q3P A;  4RHI A;  5HJ9 A;  1WOG A;  1TA1 A;  1XFK A;  4FCK A;  1P8M A;  3MMR A;  1WOH A;  4Q3U A;  1HQG A;  3MFV A;  4MXR A;  4I06 A;  1CEV A;  1T4S A;  1P8R A;  3GMZ A;  3CEV A;  1WVA A;  4Q3R A;  4IE3 A;  4GWD A;  3GN0 A;  2A0M A;  1P8Q A;  3SL0 A;  2CEV A;  4IXU A;  1P8O A;  1T4T A;  4Q3Q A;  4IE1 A;  3THJ A;  4Q3V A;  4GSM A;  3SL1 A;  4Q40 A;  2PHA A;  3LHL A;  4Q3S A;  4CEV A;  4RLA A;  4MYK A;  2ZAV A;  1HQF A;  4RHQ A;  3NIQ A;  3TH7 A;  2PLL A;  1GQ6 A;  3E6V A;  3LP4 A;  4IE2 A;  1ZPG A;  2AEB A;  3NIP A;  3SJT A;  3THH A;  4MYF A;  1P8P A;  4GWC A;  5RLA A;  4Q3T A;  3MJL A;  4GSZ A;  4G3H A;  3PZL A;  1R1O A;  1HQ5 A;  3THE A;  2PHO A;  3KV2 A;  4IU4 A;  3DJ8 A;  4Q41 A;  1RLA A;  4IU5 A;  1ZPE A;  3E8Q A;  1HQX A;  4FCI A;  1P8N A;  3M1R A;  4HXQ A;  1TBL A;  4HZE A;  4RHL A;  3SKK A;  1GQ7 A;  1WOI A;  4RHM A;  1D3V A;  1T4R A;  4DZ4 A;  1PQ3 A;  3E6K A;  4IU0 A;  3E8Z A;  3F80 A;  5HJA A;  1T5G A;  1T4P A;  4RHJ A;  4IXV A;  3RLA A;  2EF5 A;  2RLA A;  3NIO A;  4Q42 A;  3TF3 A;  1WVB A;  5CEV A; 
#chains in the Genus database with same CATH topology
 1T5F A;  1P8S A;  3EZP A;  3SFH A;  4ITY A;  5G0J A;  4Q3R C;  5THU A;  5G1B A;  3MFW A;  3LP7 A;  3MEN A;  4CBT A;  2EIV A;  3SFF A;  1HQH A;  1ZZ0 A;  5DC8 A;  5DC7 A;  1TBJ A;  4GSV A;  4HWW A;  1TBH A;  4RHK A;  2VQJ A;  4IU1 A;  5EFN A;  3ZNR A;  5JI5 A;  3E9B A;  2EF4 A;  3EZT A;  3C10 A;  4ZUN A;  4LXZ A;  5EFG A;  5D1C A;  1C3R A;  4MYN A;  4MYL A;  5G17 A;  4Q3P A;  5G3W A;  4RHI A;  4ZUR A;  1WOG A;  5HJ9 A;  1TA1 A;  4BKX B;  5EEN A;  1VKG A;  2VQV A;  5G0I A;  2VQO A;  1XFK A;  1ZZ3 A;  4FCK A;  1P8M A;  3MMR A;  5G11 A;  5DC6 A;  1WOH A;  4Q3U A;  1HQG A;  5G12 A;  3MFV A;  4MXR A;  4I06 A;  1CEV A;  4A69 A;  2VQQ A;  1T4S A;  1P8R A;  4QA5 A;  2GH6 A;  3GMZ A;  5G0G A;  5EFJ D;  5THT A;  4BZ8 A;  3CEV A;  1WVA A;  5IX0 A;  4Q3R A;  3MZ4 A;  4BZ7 A;  5DC5 A;  3C0Z A;  5EF7 A;  3MZ7 A;  5EFH A;  3Q9B A;  4IE3 A;  5IWG A;  4QA7 A;  5G0H A;  2VQM A;  3GN0 A;  2A0M A;  3Q9C A;  4GWD A;  4LY1 A;  1P8Q A;  3SL0 A;  2CEV A;  2VCG A;  4IXU A;  4QA4 A;  1P8O A;  4RN1 A;  4CQF A;  1T4T A;  4Q3Q A;  4IE1 A;  3THJ A;  4Q3V A;  5LI3 A;  4GSM A;  3SL1 A;  4ZUP A;  4Q40 A;  2PHA A;  3LHL A;  1W22 A;  4Q3S A;  4BZ5 A;  4RLA A;  4CEV A;  4MYK A;  2ZAV A;  1HQF A;  4RHQ A;  3NIQ A;  5G0X A;  3TH7 A;  2PLL A;  4ZUQ A;  5G10 A;  1GQ6 A;  3E6V A;  3LP4 A;  4IE2 A;  5G1C A;  5G13 A;  1ZPG A;  2AEB A;  3NIP A;  3Q9F A;  3RQD A;  3SJT A;  4RN0 A;  3THH A;  4MYF A;  1P8P A;  3F0R A;  4GWC A;  5G0Y A;  5RLA A;  3ZNS A;  4Q3T A;  4QA0 A;  3MJL A;  4GSZ A;  5EF8 A;  5EFK B;  4G3H A;  3PZL A;  1C3P A;  1R1O A;  1HQ5 A;  3THE A;  2PHO A;  2VQW G;  3KV2 A;  4IU4 A;  4QA6 A;  3DJ8 A;  4ZUO A;  4Q41 A;  1T69 A;  5G1A A;  3EWF A;  3MZ6 A;  1RLA A;  4IU5 A;  1ZPE A;  4BZ6 A;  5THS A;  3E8Q A;  4RN2 A;  1HQX A;  4FCI A;  5EFB D;  1P8N A;  4QA1 A;  3M1R A;  5A2S A;  4HXQ A;  1TBL A;  3F06 A;  5EEK A;  4HZE A;  4RHL A;  1ZZ1 A;  1GQ7 A;  3SKK A;  4ZUM A;  1WOI A;  3C0Y A;  4RHM A;  3MZ3 A;  1D3V A;  5BWZ A;  4CBY A;  1T4R A;  5FCW A;  4QA2 A;  4DZ4 A;  1T67 A;  1PQ3 A;  3E6K A;  4BZ9 A;  5EEF A;  2V5W A;  4IU0 A;  5EEI A;  3E8Z A;  3Q9E A;  5EEM A;  3F80 A;  5FUE A;  5THV A;  5HJA A;  1T5G A;  5ICN B;  1T4P A;  4QA3 A;  4RHJ A;  1C3S A;  4IXV A;  2V5X A;  3EW8 A;  5D1B A;  5D1D A;  3RLA A;  2EF5 A;  1T64 A;  2RLA A;  3F07 A;  3MAX A;  3NIO A;  1WVB A;  4Q42 A;  3TF3 A;  5CEV A; 
#chains in the Genus database with same CATH homology
 1T5F A;  1P8S A;  4ITY A;  4Q3R C;  3MFW A;  3LP7 A;  2EIV A;  1HQH A;  1TBJ A;  4GSV A;  4HWW A;  1TBH A;  4RHK A;  4IU1 A;  3E9B A;  2EF4 A;  4MYN A;  4MYL A;  4Q3P A;  4RHI A;  5HJ9 A;  1WOG A;  1TA1 A;  1XFK A;  4FCK A;  1P8M A;  3MMR A;  1WOH A;  4Q3U A;  1HQG A;  3MFV A;  4MXR A;  4I06 A;  1CEV A;  1T4S A;  1P8R A;  3GMZ A;  3CEV A;  1WVA A;  4Q3R A;  4IE3 A;  4GWD A;  3GN0 A;  2A0M A;  1P8Q A;  3SL0 A;  2CEV A;  4IXU A;  1P8O A;  1T4T A;  4Q3Q A;  4IE1 A;  3THJ A;  4Q3V A;  4GSM A;  3SL1 A;  4Q40 A;  2PHA A;  3LHL A;  4Q3S A;  4CEV A;  4RLA A;  4MYK A;  2ZAV A;  1HQF A;  4RHQ A;  3NIQ A;  3TH7 A;  2PLL A;  1GQ6 A;  3E6V A;  3LP4 A;  4IE2 A;  1ZPG A;  2AEB A;  3NIP A;  3SJT A;  3THH A;  4MYF A;  1P8P A;  4GWC A;  5RLA A;  4Q3T A;  3MJL A;  4GSZ A;  4G3H A;  3PZL A;  1R1O A;  1HQ5 A;  3THE A;  2PHO A;  3KV2 A;  4IU4 A;  3DJ8 A;  4Q41 A;  1RLA A;  4IU5 A;  1ZPE A;  3E8Q A;  1HQX A;  4FCI A;  1P8N A;  3M1R A;  4HXQ A;  1TBL A;  4HZE A;  4RHL A;  3SKK A;  1GQ7 A;  1WOI A;  4RHM A;  1D3V A;  1T4R A;  4DZ4 A;  1PQ3 A;  3E6K A;  4IU0 A;  3E8Z A;  3F80 A;  5HJA A;  1T5G A;  1T4P A;  4RHJ A;  4IXV A;  3RLA A;  2EF5 A;  2RLA A;  3NIO A;  4Q42 A;  3TF3 A;  1WVB A;  5CEV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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