5EF8A

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with panobinostat
Total Genus 143
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
143
sequence length
357
structure length
357
Chain Sequence
PITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
total genus 143
structure length 357
sequence length 357
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5ef8A00
5THSA 3MENA 3EW8A 1ZZ1A 4A69A 3MAXA 3MZ6A 4BKXB 3Q9BA 4QA7A 5D1DA 5G0HA 1C3SA 5ICNB 4ZUOA 2VQJA 1W22A 5G11A 5FUEA 5G1CA 3RQDA 3SFHA 5IX0A 3F06A 5IWGA 5DC8A 5EEMA 1T64A 5THUA 5G10A 5THTA 5DC7A 5DC5A 4CBTA 5D1BA 5JI5A 1ZZ3A 4RN0A 3F07A 3Q9FA 3EZTA 5EFGA 3SFFA 4QA1A 3EZPA 4ZUNA 5BWZA 4QA2A 5EEFA 3ZNRA 5EFBD 5G17A 4QA4A 5G3WA 2V5XA 1C3PA 3F0RA 4BZ5A 3MZ7A 3ZNSA 1ZZ0A 5G0GA 3EWFA 5EFHA 2GH6A 1VKGA 5EFKB 2VCGA 5G1BA 4CBYA 4BZ8A 5DC6A 4BZ7A 2VQVA 4BZ6A 4ZUMA 5EF7A 5LI3A 5G0XA 1T67A 4RN1A 5G0IA 1C3RA 2VQMA 2VQQA 5G0JA 4BZ9A 5G12A 2VQWG 4LY1A 4QA3A 5D1CA 3Q9CA 4ZUPA 4ZURA 5G1AA 5EEKA 5A2SA 5EF8A 3MZ3A 5G0YA 2V5WA 3C0YA 4CQFA 3C10A 1T69A 3MZ4A 4ZUQA 2VQOA 5THVA 5EENA 5EEIA 5EFJD 4LXZA 4QA5A 5EFNA 5G13A 3C0ZA 4QA0A 4RN2A 5FCWA 4QA6A 3Q9EA
chains in the Genus database with same CATH superfamily
5THSA 3MENA 1P8NA 4GSZA 4RHJA 3EW8A 1ZZ1A 4Q3RC 1ZPEA 4A69A 1P8QA 3MAXA 3MZ6A 4BKXB 3Q9BA 4Q3UA 4Q3RA 4QA7A 4RHKA 5D1DA 5G0HA 1C3SA 2EIVA 4GWDA 4ZUOA 5ICNB 1HQXA 2VQJA 1W22A 3LHLA 3MMRA 5G11A 4FCIA 5FUEA 5G1CA 3RQDA 4RHLA 3SFHA 5IX0A 1ZPGA 1R1OA 3M1RA 4MYFA 1P8OA 3GMZA 4IE3A 1HQHA 3SKKA 1TBLA 3F06A 1T4SA 4IU1A 4HZEA 5IWGA 3KV2A 1P8PA 3MJLA 5DC8A 5EEMA 1T64A 3TH7A 5THUA 3SJTA 4CEVA 4I06A 3E9BA 4GSVA 5G10A 2ZAVA 1WVAA 1D3VA 3F80A 3GN0A 4IU0A 5THTA 4MYNA 5DC7A 5DC5A 2CEVA 4Q3VA 4RHIA 1P8MA 3DJ8A 4CBTA 5D1BA 4IXVA 5JI5A 1ZZ3A 4RHMA 4GWCA 3THHA 4RN0A 1HQ5A 3F07A 3Q9FA 3EZTA 5EFGA 3SFFA 4QA1A 3EZPA 4ZUNA 5BWZA 3LP4A 2RLAA 2PHOA 4Q3PA 3E8QA 4QA2A 5EEFA 3ZNRA 3E8ZA 5EFBD 5G17A 4QA4A 1HQFA 5G3WA 4MXRA 1P8SA 1C3PA 2V5XA 3F0RA 5HJ9A 3MZ7A 4BZ5A 3TF3A 3ZNSA 1T4RA 1ZZ0A 4Q3QA 1WOIA 3EWFA 4HXQA 2GH6A 3CEVA 5EFHA 1VKGA 5G0GA 3PZLA 1T4TA 5EFKB 2VCGA 3RLAA 3MFVA 5G1BA 4CBYA 4BZ8A 4RHQA 1WVBA 2EF5A 3LP7A 5DC6A 1HQGA 4BZ7A 4DZ4A 4Q42A 2VQVA 1XFKA 5HJAA 1T5FA 3THEA 4IE2A 4ITYA 4BZ6A 4IU5A 4IE1A 4ZUMA 5EF7A 1GQ7A 5LI3A 5G0XA 1TBHA 1T67A 4MYKA 2EF4A 4RN1A 5G0IA 1C3RA 1GQ6A 1TBJA 2VQMA 4RLAA 4IU4A 3SL0A 2VQQA 4FCKA 4HWWA 5G0JA 4BZ9A 4GSMA 5G12A 2VQWG 4LY1A 4QA3A 5D1CA 3Q9CA 4ZUPA 1T5GA 4MYLA 4ZURA 1CEVA 5G1AA 3THJA 5EEKA 5A2SA 5EF8A 3MZ3A 5RLAA 5G0YA 3NIOA 4Q40A 2V5WA 3C0YA 3SL1A 4CQFA 1T4PA 1T69A 1WOGA 3C10A 3MZ4A 4ZUQA 3NIQA 2VQOA 1PQ3A 5THVA 5EENA 1P8RA 4Q41A 4Q3SA 4IXUA 1TA1A 3E6KA 4G3HA 5EEIA 5EFJD 3NIPA 4LXZA 5CEVA 4QA5A 5EFNA 2AEBA 5G13A 3C0ZA 2A0MA 1WOHA 4QA0A 4Q3TA 1RLAA 4RN2A 2PLLA 3E6VA 5FCWA 4QA6A 3Q9EA 2PHAA 3MFWA
chains in the Genus database with same CATH topology
5THSA 3MENA 3EW8A 1ZZ1A 4A69A 3MAXA 3MZ6A 4BKXB 3Q9BA 4QA7A 5D1DA 5G0HA 1C3SA 5ICNB 4ZUOA 2VQJA 1W22A 5G11A 5FUEA 5G1CA 3RQDA 3SFHA 5IX0A 3F06A 5IWGA 5DC8A 5EEMA 1T64A 5THUA 5G10A 5THTA 5DC7A 5DC5A 4CBTA 5D1BA 5JI5A 1ZZ3A 4RN0A 3F07A 3Q9FA 3EZTA 5EFGA 3SFFA 4QA1A 3EZPA 4ZUNA 5BWZA 4QA2A 5EEFA 3ZNRA 5EFBD 5G17A 4QA4A 5G3WA 2V5XA 1C3PA 3F0RA 4BZ5A 3MZ7A 3ZNSA 1ZZ0A 5G0GA 3EWFA 5EFHA 2GH6A 1VKGA 5EFKB 2VCGA 5G1BA 4CBYA 4BZ8A 5DC6A 4BZ7A 2VQVA 4BZ6A 4ZUMA 5EF7A 5LI3A 5G0XA 1T67A 4RN1A 5G0IA 1C3RA 2VQMA 2VQQA 5G0JA 4BZ9A 5G12A 2VQWG 4LY1A 4QA3A 5D1CA 3Q9CA 4ZUPA 4ZURA 5G1AA 5EEKA 5A2SA 5EF8A 3MZ3A 5G0YA 2V5WA 3C0YA 4CQFA 3C10A 1T69A 3MZ4A 4ZUQA 2VQOA 5THVA 5EENA 5EEIA 5EFJD 4LXZA 4QA5A 5EFNA 5G13A 3C0ZA 4QA0A 4RN2A 5FCWA 4QA6A 3Q9EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5THS A;  3MEN A;  3EW8 A;  1ZZ1 A;  4A69 A;  3MAX A;  3MZ6 A;  4BKX B;  3Q9B A;  4QA7 A;  5D1D A;  5G0H A;  1C3S A;  5ICN B;  4ZUO A;  2VQJ A;  1W22 A;  5G11 A;  5FUE A;  5G1C A;  3RQD A;  3SFH A;  5IX0 A;  3F06 A;  5IWG A;  5DC8 A;  5EEM A;  1T64 A;  5THU A;  5G10 A;  5THT A;  5DC7 A;  5DC5 A;  4CBT A;  5D1B A;  5JI5 A;  1ZZ3 A;  4RN0 A;  3F07 A;  3Q9F A;  3EZT A;  5EFG A;  3SFF A;  4QA1 A;  3EZP A;  4ZUN A;  5BWZ A;  4QA2 A;  5EEF A;  3ZNR A;  5EFB D;  5G17 A;  4QA4 A;  5G3W A;  2V5X A;  1C3P A;  3F0R A;  4BZ5 A;  3MZ7 A;  3ZNS A;  1ZZ0 A;  5G0G A;  3EWF A;  5EFH A;  2GH6 A;  1VKG A;  5EFK B;  2VCG A;  5G1B A;  4CBY A;  4BZ8 A;  5DC6 A;  4BZ7 A;  2VQV A;  4BZ6 A;  4ZUM A;  5EF7 A;  5LI3 A;  5G0X A;  1T67 A;  4RN1 A;  5G0I A;  1C3R A;  2VQM A;  2VQQ A;  5G0J A;  4BZ9 A;  5G12 A;  2VQW G;  4LY1 A;  4QA3 A;  5D1C A;  3Q9C A;  4ZUP A;  4ZUR A;  5G1A A;  5EEK A;  5A2S A;  5EF8 A;  3MZ3 A;  5G0Y A;  2V5W A;  3C0Y A;  4CQF A;  3C10 A;  1T69 A;  3MZ4 A;  4ZUQ A;  2VQO A;  5THV A;  5EEN A;  5EEI A;  5EFJ D;  4LXZ A;  4QA5 A;  5EFN A;  5G13 A;  3C0Z A;  4QA0 A;  4RN2 A;  5FCW A;  4QA6 A;  3Q9E A; 
#chains in the Genus database with same CATH topology
 5THS A;  3MEN A;  1P8N A;  4GSZ A;  4RHJ A;  3EW8 A;  1ZZ1 A;  4Q3R C;  1ZPE A;  4A69 A;  1P8Q A;  3MAX A;  3MZ6 A;  4BKX B;  3Q9B A;  4Q3U A;  4Q3R A;  4QA7 A;  4RHK A;  5D1D A;  5G0H A;  1C3S A;  2EIV A;  4GWD A;  4ZUO A;  5ICN B;  1HQX A;  2VQJ A;  1W22 A;  3LHL A;  3MMR A;  5G11 A;  4FCI A;  5FUE A;  5G1C A;  3RQD A;  4RHL A;  3SFH A;  5IX0 A;  1ZPG A;  1R1O A;  3M1R A;  4MYF A;  1P8O A;  3GMZ A;  4IE3 A;  1HQH A;  3SKK A;  1TBL A;  3F06 A;  1T4S A;  4IU1 A;  4HZE A;  5IWG A;  3KV2 A;  1P8P A;  3MJL A;  5DC8 A;  5EEM A;  1T64 A;  3TH7 A;  5THU A;  3SJT A;  4CEV A;  4I06 A;  3E9B A;  4GSV A;  5G10 A;  2ZAV A;  1WVA A;  1D3V A;  3F80 A;  3GN0 A;  4IU0 A;  5THT A;  4MYN A;  5DC7 A;  5DC5 A;  2CEV A;  4Q3V A;  4RHI A;  1P8M A;  3DJ8 A;  4CBT A;  5D1B A;  4IXV A;  5JI5 A;  1ZZ3 A;  4RHM A;  4GWC A;  3THH A;  4RN0 A;  1HQ5 A;  3F07 A;  3Q9F A;  3EZT A;  5EFG A;  3SFF A;  4QA1 A;  3EZP A;  4ZUN A;  5BWZ A;  3LP4 A;  2RLA A;  2PHO A;  4Q3P A;  3E8Q A;  4QA2 A;  5EEF A;  3ZNR A;  3E8Z A;  5EFB D;  5G17 A;  4QA4 A;  1HQF A;  5G3W A;  4MXR A;  1P8S A;  1C3P A;  2V5X A;  3F0R A;  5HJ9 A;  3MZ7 A;  4BZ5 A;  3TF3 A;  3ZNS A;  1T4R A;  1ZZ0 A;  4Q3Q A;  1WOI A;  3EWF A;  4HXQ A;  2GH6 A;  3CEV A;  5EFH A;  1VKG A;  5G0G A;  3PZL A;  1T4T A;  5EFK B;  2VCG A;  3RLA A;  3MFV A;  5G1B A;  4CBY A;  4BZ8 A;  4RHQ A;  1WVB A;  2EF5 A;  3LP7 A;  5DC6 A;  1HQG A;  4BZ7 A;  4DZ4 A;  4Q42 A;  2VQV A;  1XFK A;  5HJA A;  1T5F A;  3THE A;  4IE2 A;  4ITY A;  4BZ6 A;  4IU5 A;  4IE1 A;  4ZUM A;  5EF7 A;  1GQ7 A;  5LI3 A;  5G0X A;  1TBH A;  1T67 A;  4MYK A;  2EF4 A;  4RN1 A;  5G0I A;  1C3R A;  1GQ6 A;  1TBJ A;  2VQM A;  4RLA A;  4IU4 A;  3SL0 A;  2VQQ A;  4FCK A;  4HWW A;  5G0J A;  4BZ9 A;  4GSM A;  5G12 A;  2VQW G;  4LY1 A;  4QA3 A;  5D1C A;  3Q9C A;  4ZUP A;  1T5G A;  4MYL A;  4ZUR A;  1CEV A;  5G1A A;  3THJ A;  5EEK A;  5A2S A;  5EF8 A;  3MZ3 A;  5RLA A;  5G0Y A;  3NIO A;  4Q40 A;  2V5W A;  3C0Y A;  3SL1 A;  4CQF A;  1T4P A;  1T69 A;  1WOG A;  3C10 A;  3MZ4 A;  4ZUQ A;  3NIQ A;  2VQO A;  1PQ3 A;  5THV A;  5EEN A;  1P8R A;  4Q41 A;  4Q3S A;  4IXU A;  1TA1 A;  3E6K A;  4G3H A;  5EEI A;  5EFJ D;  3NIP A;  4LXZ A;  5CEV A;  4QA5 A;  5EFN A;  2AEB A;  5G13 A;  3C0Z A;  2A0M A;  1WOH A;  4QA0 A;  4Q3T A;  1RLA A;  4RN2 A;  2PLL A;  3E6V A;  5FCW A;  4QA6 A;  3Q9E A;  2PHA A;  3MFW A; 
#chains in the Genus database with same CATH homology
 5THS A;  3MEN A;  3EW8 A;  1ZZ1 A;  4A69 A;  3MAX A;  3MZ6 A;  4BKX B;  3Q9B A;  4QA7 A;  5D1D A;  5G0H A;  1C3S A;  5ICN B;  4ZUO A;  2VQJ A;  1W22 A;  5G11 A;  5FUE A;  5G1C A;  3RQD A;  3SFH A;  5IX0 A;  3F06 A;  5IWG A;  5DC8 A;  5EEM A;  1T64 A;  5THU A;  5G10 A;  5THT A;  5DC7 A;  5DC5 A;  4CBT A;  5D1B A;  5JI5 A;  1ZZ3 A;  4RN0 A;  3F07 A;  3Q9F A;  3EZT A;  5EFG A;  3SFF A;  4QA1 A;  3EZP A;  4ZUN A;  5BWZ A;  4QA2 A;  5EEF A;  3ZNR A;  5EFB D;  5G17 A;  4QA4 A;  5G3W A;  2V5X A;  1C3P A;  3F0R A;  4BZ5 A;  3MZ7 A;  3ZNS A;  1ZZ0 A;  5G0G A;  3EWF A;  5EFH A;  2GH6 A;  1VKG A;  5EFK B;  2VCG A;  5G1B A;  4CBY A;  4BZ8 A;  5DC6 A;  4BZ7 A;  2VQV A;  4BZ6 A;  4ZUM A;  5EF7 A;  5LI3 A;  5G0X A;  1T67 A;  4RN1 A;  5G0I A;  1C3R A;  2VQM A;  2VQQ A;  5G0J A;  4BZ9 A;  5G12 A;  2VQW G;  4LY1 A;  4QA3 A;  5D1C A;  3Q9C A;  4ZUP A;  4ZUR A;  5G1A A;  5EEK A;  5A2S A;  5EF8 A;  3MZ3 A;  5G0Y A;  2V5W A;  3C0Y A;  4CQF A;  3C10 A;  1T69 A;  3MZ4 A;  4ZUQ A;  2VQO A;  5THV A;  5EEN A;  5EEI A;  5EFJ D;  4LXZ A;  4QA5 A;  5EFN A;  5G13 A;  3C0Z A;  4QA0 A;  4RN2 A;  5FCW A;  4QA6 A;  3Q9E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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