5EFHA

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with trifluoroketone transition state analogue
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
sequence length
356
structure length
356
Chain Sequence
ITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
total genus 141
structure length 356
sequence length 356
chains with identical sequence D
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5efhA00
4CBYA 4QA6A 5G0HA 2VQOA 4LXZA 3EWFA 4BZ7A 5G3WA 4BZ8A 1T64A 5D1DA 3EW8A 4QA7A 5DC5A 1C3RA 5EEFA 4RN0A 3MZ4A 5EF8A 5BWZA 1T67A 2VQVA 4QA5A 4QA4A 1C3SA 4ZUQA 5G11A 5IWGA 5G0JA 1VKGA 5G12A 5EFGA 3F06A 3ZNSA 5G0YA 2VQWG 3MENA 5EFBD 4BZ6A 1C3PA 5G0GA 5DC6A 5G1CA 4BZ5A 4CQFA 3MAXA 3F0RA 5D1BA 2VQMA 1ZZ1A 2VCGA 3MZ7A 3MZ3A 5JI5A 3Q9CA 4ZURA 5G13A 2VQQA 5G10A 5G0IA 5EF7A 5FCWA 3SFHA 3MZ6A 5IX0A 4RN1A 1T69A 5DC8A 3F07A 3RQDA 4QA3A 5EFNA 3C0ZA 4QA2A 5THSA 2V5WA 4A69A 5D1CA 4ZUMA 5G1AA 4BZ9A 3Q9FA 5EEIA 5EEMA 5THUA 3Q9EA 1W22A 4QA0A 5FUEA 2V5XA 3EZTA 2VQJA 5EFHA 5ICNB 5G0XA 5EENA 5A2SA 3SFFA 4BKXB 1ZZ3A 3Q9BA 5EEKA 1ZZ0A 3C0YA 4RN2A 3EZPA 4ZUNA 3ZNRA 4ZUOA 5EFKB 5THTA 5EFJD 5G1BA 5DC7A 5THVA 2GH6A 3C10A 4QA1A 4CBTA 4ZUPA 5G17A 5LI3A 4LY1A
chains in the Genus database with same CATH superfamily
1GQ6A 4RHMA 3RLAA 2EF5A 4CBYA 4Q41A 4Q3RA 4GWCA 4Q3PA 1TBHA 4QA6A 5G0HA 2VQOA 4LXZA 3EWFA 1P8OA 4HXQA 3SKKA 4IU1A 1T4SA 4MYKA 5G3WA 5HJ9A 4BZ7A 3MMRA 1TBLA 3TH7A 3THEA 1HQHA 4G3HA 4BZ8A 1T64A 4HZEA 1T4PA 1T5GA 4I06A 5D1DA 3EW8A 4IU5A 4QA7A 4FCIA 5DC5A 1C3RA 3LP4A 4RN0A 1P8PA 1ZPGA 3NIPA 1RLAA 1TA1A 3MZ4A 5EF8A 5EEFA 4IE1A 5BWZA 1T67A 4GSVA 4GSMA 1XFKA 4MYFA 2VQVA 5RLAA 3GMZA 4Q3RC 4QA5A 4IXUA 4Q3UA 1C3SA 4IXVA 4QA4A 2ZAVA 4ZUQA 1R1OA 5HJAA 5G11A 5IWGA 5G0JA 1VKGA 5G12A 3GN0A 1ZPEA 1WOIA 5EFGA 5CEVA 4GWDA 3KV2A 3TF3A 3F06A 3THHA 2EIVA 1T5FA 1HQGA 1WVAA 5G0YA 3ZNSA 4MYNA 2VQWG 3MENA 5EFBD 4BZ6A 3MFVA 1HQXA 1C3PA 5G0GA 5DC6A 5G1CA 3MJLA 4BZ5A 4CQFA 3MAXA 3F0RA 3F80A 2VQMA 5D1BA 1ZZ1A 2VCGA 3MZ7A 4IE3A 4RHQA 1HQFA 4Q3VA 3MZ3A 5JI5A 3NIQA 4ITYA 3Q9CA 1P8SA 4ZURA 5G13A 2VQQA 5G10A 2AEBA 1WVBA 5G0IA 1D3VA 5EF7A 5FCWA 3SFHA 3MZ6A 3E9BA 5IX0A 4RN1A 1T69A 1P8RA 5DC8A 3SL0A 3LHLA 4FCKA 3F07A 3RQDA 3THJA 4QA3A 2CEVA 4HWWA 5EFNA 4IU0A 1GQ7A 3C0ZA 3DJ8A 3SL1A 4QA2A 5THSA 2V5WA 4A69A 4MXRA 3SJTA 1T4RA 3MFWA 4Q40A 5D1CA 1HQ5A 4ZUMA 4DZ4A 1P8MA 5G1AA 3CEVA 1TBJA 4Q42A 1P8NA 2A0MA 4BZ9A 4CBTA 3Q9FA 5EEIA 5EEMA 5THUA 3Q9EA 3E8QA 2RLAA 1W22A 1WOGA 4IE2A 4QA0A 4Q3SA 4RHLA 4Q3TA 5FUEA 2V5XA 3EZTA 3E6VA 2VQJA 5EFHA 5ICNB 4MYLA 5G0XA 4Q3QA 5EENA 4RLAA 5A2SA 3SFFA 4BKXB 1ZZ3A 3Q9BA 5EEKA 3PZLA 2EF4A 1ZZ0A 3C0YA 2PHAA 4RN2A 3EZPA 4ZUNA 3E6KA 1PQ3A 4RHKA 4ZUOA 3ZNRA 4RHIA 3NIOA 5THVA 4IU4A 5EFKB 5THTA 5EFJD 2PHOA 5G1BA 5DC7A 1T4TA 2GH6A 3C10A 3E8ZA 3LP7A 4QA1A 4RHJA 4ZUPA 1P8QA 4GSZA 1WOHA 5G17A 2PLLA 5LI3A 4CEVA 1CEVA 4LY1A 3M1RA
chains in the Genus database with same CATH topology
4CBYA 4QA6A 5G0HA 2VQOA 4LXZA 3EWFA 4BZ7A 5G3WA 4BZ8A 1T64A 5D1DA 3EW8A 4QA7A 5DC5A 1C3RA 5EEFA 4RN0A 3MZ4A 5EF8A 5BWZA 1T67A 2VQVA 4QA5A 4QA4A 1C3SA 4ZUQA 5G11A 5IWGA 5G0JA 1VKGA 5G12A 5EFGA 3F06A 3ZNSA 5G0YA 2VQWG 3MENA 5EFBD 4BZ6A 1C3PA 5G0GA 5DC6A 5G1CA 4BZ5A 4CQFA 3MAXA 3F0RA 5D1BA 2VQMA 1ZZ1A 2VCGA 3MZ7A 3MZ3A 5JI5A 3Q9CA 4ZURA 5G13A 2VQQA 5G10A 5G0IA 5EF7A 5FCWA 3SFHA 3MZ6A 5IX0A 4RN1A 1T69A 5DC8A 3F07A 3RQDA 4QA3A 5EFNA 3C0ZA 4QA2A 5THSA 2V5WA 4A69A 5D1CA 4ZUMA 5G1AA 4BZ9A 3Q9FA 5EEIA 5EEMA 5THUA 3Q9EA 1W22A 4QA0A 5FUEA 2V5XA 3EZTA 2VQJA 5EFHA 5ICNB 5G0XA 5EENA 5A2SA 3SFFA 4BKXB 1ZZ3A 3Q9BA 5EEKA 1ZZ0A 3C0YA 4RN2A 3EZPA 4ZUNA 3ZNRA 4ZUOA 5EFKB 5THTA 5EFJD 5G1BA 5DC7A 5THVA 2GH6A 3C10A 4QA1A 4CBTA 4ZUPA 5G17A 5LI3A 4LY1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CBY A;  4QA6 A;  5G0H A;  2VQO A;  4LXZ A;  3EWF A;  4BZ7 A;  5G3W A;  4BZ8 A;  1T64 A;  5D1D A;  3EW8 A;  4QA7 A;  5DC5 A;  1C3R A;  5EEF A;  4RN0 A;  3MZ4 A;  5EF8 A;  5BWZ A;  1T67 A;  2VQV A;  4QA5 A;  4QA4 A;  1C3S A;  4ZUQ A;  5G11 A;  5IWG A;  5G0J A;  1VKG A;  5G12 A;  5EFG A;  3F06 A;  3ZNS A;  5G0Y A;  2VQW G;  3MEN A;  5EFB D;  4BZ6 A;  1C3P A;  5G0G A;  5DC6 A;  5G1C A;  4BZ5 A;  4CQF A;  3MAX A;  3F0R A;  5D1B A;  2VQM A;  1ZZ1 A;  2VCG A;  3MZ7 A;  3MZ3 A;  5JI5 A;  3Q9C A;  4ZUR A;  5G13 A;  2VQQ A;  5G10 A;  5G0I A;  5EF7 A;  5FCW A;  3SFH A;  3MZ6 A;  5IX0 A;  4RN1 A;  1T69 A;  5DC8 A;  3F07 A;  3RQD A;  4QA3 A;  5EFN A;  3C0Z A;  4QA2 A;  5THS A;  2V5W A;  4A69 A;  5D1C A;  4ZUM A;  5G1A A;  4BZ9 A;  3Q9F A;  5EEI A;  5EEM A;  5THU A;  3Q9E A;  1W22 A;  4QA0 A;  5FUE A;  2V5X A;  3EZT A;  2VQJ A;  5EFH A;  5ICN B;  5G0X A;  5EEN A;  5A2S A;  3SFF A;  4BKX B;  1ZZ3 A;  3Q9B A;  5EEK A;  1ZZ0 A;  3C0Y A;  4RN2 A;  3EZP A;  4ZUN A;  3ZNR A;  4ZUO A;  5EFK B;  5THT A;  5EFJ D;  5G1B A;  5DC7 A;  5THV A;  2GH6 A;  3C10 A;  4QA1 A;  4CBT A;  4ZUP A;  5G17 A;  5LI3 A;  4LY1 A; 
#chains in the Genus database with same CATH topology
 1GQ6 A;  4RHM A;  3RLA A;  2EF5 A;  4CBY A;  4Q41 A;  4Q3R A;  4GWC A;  4Q3P A;  1TBH A;  4QA6 A;  5G0H A;  2VQO A;  4LXZ A;  3EWF A;  1P8O A;  4HXQ A;  3SKK A;  4IU1 A;  1T4S A;  4MYK A;  5G3W A;  5HJ9 A;  4BZ7 A;  3MMR A;  1TBL A;  3TH7 A;  3THE A;  1HQH A;  4G3H A;  4BZ8 A;  1T64 A;  4HZE A;  1T4P A;  1T5G A;  4I06 A;  5D1D A;  3EW8 A;  4IU5 A;  4QA7 A;  4FCI A;  5DC5 A;  1C3R A;  3LP4 A;  4RN0 A;  1P8P A;  1ZPG A;  3NIP A;  1RLA A;  1TA1 A;  3MZ4 A;  5EF8 A;  5EEF A;  4IE1 A;  5BWZ A;  1T67 A;  4GSV A;  4GSM A;  1XFK A;  4MYF A;  2VQV A;  5RLA A;  3GMZ A;  4Q3R C;  4QA5 A;  4IXU A;  4Q3U A;  1C3S A;  4IXV A;  4QA4 A;  2ZAV A;  4ZUQ A;  1R1O A;  5HJA A;  5G11 A;  5IWG A;  5G0J A;  1VKG A;  5G12 A;  3GN0 A;  1ZPE A;  1WOI A;  5EFG A;  5CEV A;  4GWD A;  3KV2 A;  3TF3 A;  3F06 A;  3THH A;  2EIV A;  1T5F A;  1HQG A;  1WVA A;  5G0Y A;  3ZNS A;  4MYN A;  2VQW G;  3MEN A;  5EFB D;  4BZ6 A;  3MFV A;  1HQX A;  1C3P A;  5G0G A;  5DC6 A;  5G1C A;  3MJL A;  4BZ5 A;  4CQF A;  3MAX A;  3F0R A;  3F80 A;  2VQM A;  5D1B A;  1ZZ1 A;  2VCG A;  3MZ7 A;  4IE3 A;  4RHQ A;  1HQF A;  4Q3V A;  3MZ3 A;  5JI5 A;  3NIQ A;  4ITY A;  3Q9C A;  1P8S A;  4ZUR A;  5G13 A;  2VQQ A;  5G10 A;  2AEB A;  1WVB A;  5G0I A;  1D3V A;  5EF7 A;  5FCW A;  3SFH A;  3MZ6 A;  3E9B A;  5IX0 A;  4RN1 A;  1T69 A;  1P8R A;  5DC8 A;  3SL0 A;  3LHL A;  4FCK A;  3F07 A;  3RQD A;  3THJ A;  4QA3 A;  2CEV A;  4HWW A;  5EFN A;  4IU0 A;  1GQ7 A;  3C0Z A;  3DJ8 A;  3SL1 A;  4QA2 A;  5THS A;  2V5W A;  4A69 A;  4MXR A;  3SJT A;  1T4R A;  3MFW A;  4Q40 A;  5D1C A;  1HQ5 A;  4ZUM A;  4DZ4 A;  1P8M A;  5G1A A;  3CEV A;  1TBJ A;  4Q42 A;  1P8N A;  2A0M A;  4BZ9 A;  4CBT A;  3Q9F A;  5EEI A;  5EEM A;  5THU A;  3Q9E A;  3E8Q A;  2RLA A;  1W22 A;  1WOG A;  4IE2 A;  4QA0 A;  4Q3S A;  4RHL A;  4Q3T A;  5FUE A;  2V5X A;  3EZT A;  3E6V A;  2VQJ A;  5EFH A;  5ICN B;  4MYL A;  5G0X A;  4Q3Q A;  5EEN A;  4RLA A;  5A2S A;  3SFF A;  4BKX B;  1ZZ3 A;  3Q9B A;  5EEK A;  3PZL A;  2EF4 A;  1ZZ0 A;  3C0Y A;  2PHA A;  4RN2 A;  3EZP A;  4ZUN A;  3E6K A;  1PQ3 A;  4RHK A;  4ZUO A;  3ZNR A;  4RHI A;  3NIO A;  5THV A;  4IU4 A;  5EFK B;  5THT A;  5EFJ D;  2PHO A;  5G1B A;  5DC7 A;  1T4T A;  2GH6 A;  3C10 A;  3E8Z A;  3LP7 A;  4QA1 A;  4RHJ A;  4ZUP A;  1P8Q A;  4GSZ A;  1WOH A;  5G17 A;  2PLL A;  5LI3 A;  4CEV A;  1CEV A;  4LY1 A;  3M1R A; 
#chains in the Genus database with same CATH homology
 4CBY A;  4QA6 A;  5G0H A;  2VQO A;  4LXZ A;  3EWF A;  4BZ7 A;  5G3W A;  4BZ8 A;  1T64 A;  5D1D A;  3EW8 A;  4QA7 A;  5DC5 A;  1C3R A;  5EEF A;  4RN0 A;  3MZ4 A;  5EF8 A;  5BWZ A;  1T67 A;  2VQV A;  4QA5 A;  4QA4 A;  1C3S A;  4ZUQ A;  5G11 A;  5IWG A;  5G0J A;  1VKG A;  5G12 A;  5EFG A;  3F06 A;  3ZNS A;  5G0Y A;  2VQW G;  3MEN A;  5EFB D;  4BZ6 A;  1C3P A;  5G0G A;  5DC6 A;  5G1C A;  4BZ5 A;  4CQF A;  3MAX A;  3F0R A;  5D1B A;  2VQM A;  1ZZ1 A;  2VCG A;  3MZ7 A;  3MZ3 A;  5JI5 A;  3Q9C A;  4ZUR A;  5G13 A;  2VQQ A;  5G10 A;  5G0I A;  5EF7 A;  5FCW A;  3SFH A;  3MZ6 A;  5IX0 A;  4RN1 A;  1T69 A;  5DC8 A;  3F07 A;  3RQD A;  4QA3 A;  5EFN A;  3C0Z A;  4QA2 A;  5THS A;  2V5W A;  4A69 A;  5D1C A;  4ZUM A;  5G1A A;  4BZ9 A;  3Q9F A;  5EEI A;  5EEM A;  5THU A;  3Q9E A;  1W22 A;  4QA0 A;  5FUE A;  2V5X A;  3EZT A;  2VQJ A;  5EFH A;  5ICN B;  5G0X A;  5EEN A;  5A2S A;  3SFF A;  4BKX B;  1ZZ3 A;  3Q9B A;  5EEK A;  1ZZ0 A;  3C0Y A;  4RN2 A;  3EZP A;  4ZUN A;  3ZNR A;  4ZUO A;  5EFK B;  5THT A;  5EFJ D;  5G1B A;  5DC7 A;  5THV A;  2GH6 A;  3C10 A;  4QA1 A;  4CBT A;  4ZUP A;  5G17 A;  5LI3 A;  4LY1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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